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Conserved domains on  [gi|19924099|ref|NP_008881|]
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synapsin-1 isoform Ia [Homo sapiens]

Protein Classification

ATP-grasp domain-containing protein; acetate--CoA ligase family protein( domain architecture ID 10566049)

ATP-grasp domain-containing protein may be related to carbamoyl phosphate synthetase and predicted to be involved in the biosynthesis of a ribonucleoside involved in stress response; acetate--CoA ligase family protein similar to ADP-forming acetate--CoA ligase that catalyzes the formation of acetate and ATP from acetyl-CoA by using ADP and phosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CPSase_L_D2 super family cl17255
Carbamoyl-phosphate synthase L chain, ATP binding domain; Carbamoyl-phosphate synthase ...
 214-416 1.76e-137

Carbamoyl-phosphate synthase L chain, ATP binding domain; Carbamoyl-phosphate synthase catalyzes the ATP-dependent synthesis of carbamyl-phosphate from glutamine or ammonia and bicarbonate. This important enzyme initiates both the urea cycle and the biosynthesis of arginine and/or pyrimidines. The carbamoyl-phosphate synthase (CPS) enzyme in prokaryotes is a heterodimer of a small and large chain. The small chain promotes the hydrolysis of glutamine to ammonia, which is used by the large chain to synthesize carbamoyl phosphate. See pfam00988. The small chain has a GATase domain in the carboxyl terminus. See pfam00117. The ATP binding domain (this one) has an ATP-grasp fold.


The actual alignment was detected with superfamily member pfam02750:

Pssm-ID: 473076  Cd Length: 203  Bit Score: 401.74  E-value: 1.76e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   214 NSLHSVYNFCDKPWVFAQMVRLHKKLGTEEFPLIDQTFYPNHKEMLSSTTYPVVVKMGHAHSGMGKVKVDNQHDFQDIAS 293
Cdd:pfam02750   1 NSLESIYNFCDKPWVFAQLIAIFHSLGGEKFPLIEQTFFPNHKEMLTAPNFPVVIKIGHAHAGMGKIKVENHHDFQDIAS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   294 VVALTKTYATAEPFIDAKYDVRVQKIGQNYKAYMRTSVSGNWKTNTGSAMLEQIAMSDRYKLWVDTCSEIFGGLDICAVE 373
Cdd:pfam02750  81 VVALAKTYATAEAFIDSKYDIRIQKIGNNYKAYMRTSISGNWKANTGSAMLEQIAMSDRYKLWVDSCSEMFGGLDICAVK 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 19924099   374 ALHGKDGRDHIIEVVGSSMPLIGDHQDEDKQLIVELVVNKMAQ 416
Cdd:pfam02750 161 AVHGKDGKDYIFEVMDCSMPLIGEHQEEDKQLIADLVISKMNQ 203
Synapsin pfam02078
Synapsin, N-terminal domain; This family is structurally related to the PreATP-grasp domain.
 115-212 1.59e-60

Synapsin, N-terminal domain; This family is structurally related to the PreATP-grasp domain.


:

Pssm-ID: 460438  Cd Length: 97  Bit Score: 197.87  E-value: 1.59e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   115 VLLVIDEPHTDWAKYFKGKKIHGEIDIKVEQAEFSDLNLVAHANGGFSVDMEVLRNGVKVVRSLKPDFVLIRQHAFsmAR 194
Cdd:pfam02078   2 TLLVIDDQHTDWSKYFRGKKIHGDYDIRVEQAEFSELNLTAYADGGCVVDMQVIRNGTKVVRSFRPDFVLVRQHAR--DA 79

                          90
                  ....*....|....*...
gi 19924099   195 NGDYRSLVIGLQYAGIPS 212
Cdd:pfam02078  80 GEDYRNLLLGLQYGGVPS 97
Synapsin_N super family cl11206
Synapsin N-terminal; This highly conserved domain of synapsin proteins has a serine at ...
 1-27 1.49e-11

Synapsin N-terminal; This highly conserved domain of synapsin proteins has a serine at position 9 or 10 which is a phosphorylation site. The domain appears to be the part of the molecule that binds to calmodulin.


The actual alignment was detected with superfamily member pfam10581:

Pssm-ID: 463155  Cd Length: 32  Bit Score: 59.43  E-value: 1.49e-11
                          10        20
                  ....*....|....*....|....*..
gi 19924099     1 MNYLRRRLSDSNFMANLPNGYMTDLQR 27
Cdd:pfam10581   1 MNYLRRRLSDSNFMSNLPNGYMSDLQR 27
PRK07764 super family cl35613
DNA polymerase III subunits gamma and tau; Validated
 494-686 2.45e-08

DNA polymerase III subunits gamma and tau; Validated


The actual alignment was detected with superfamily member PRK07764:

Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 57.30  E-value: 2.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099  494 SGLGPPAGSPLPQRLPSPT--SAPQQPASQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRqtsvSG 571
Cdd:PRK07764 592 PGAAGGEGPPAPASSGPPEeaARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDG----GD 667

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099  572 PAPPKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGPGPAGRPKPQlAQKPSQDVPPPATAA 651
Cdd:PRK07764 668 GWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAP-SPAADDPVPLPPEPD 746

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 19924099  652 AGGPPHPQLNKSQSLTNAFNLPEPAPPRPSLSQDE 686
Cdd:PRK07764 747 DPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSE 781
 
Name Accession Description Interval E-value
Synapsin_C pfam02750
Synapsin, ATP binding domain; Ca dependent ATP binding in this ATP grasp fold. Function ...
 214-416 1.76e-137

Synapsin, ATP binding domain; Ca dependent ATP binding in this ATP grasp fold. Function unknown.


Pssm-ID: 308403  Cd Length: 203  Bit Score: 401.74  E-value: 1.76e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   214 NSLHSVYNFCDKPWVFAQMVRLHKKLGTEEFPLIDQTFYPNHKEMLSSTTYPVVVKMGHAHSGMGKVKVDNQHDFQDIAS 293
Cdd:pfam02750   1 NSLESIYNFCDKPWVFAQLIAIFHSLGGEKFPLIEQTFFPNHKEMLTAPNFPVVIKIGHAHAGMGKIKVENHHDFQDIAS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   294 VVALTKTYATAEPFIDAKYDVRVQKIGQNYKAYMRTSVSGNWKTNTGSAMLEQIAMSDRYKLWVDTCSEIFGGLDICAVE 373
Cdd:pfam02750  81 VVALAKTYATAEAFIDSKYDIRIQKIGNNYKAYMRTSISGNWKANTGSAMLEQIAMSDRYKLWVDSCSEMFGGLDICAVK 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 19924099   374 ALHGKDGRDHIIEVVGSSMPLIGDHQDEDKQLIVELVVNKMAQ 416
Cdd:pfam02750 161 AVHGKDGKDYIFEVMDCSMPLIGEHQEEDKQLIADLVISKMNQ 203
Synapsin pfam02078
Synapsin, N-terminal domain; This family is structurally related to the PreATP-grasp domain.
 115-212 1.59e-60

Synapsin, N-terminal domain; This family is structurally related to the PreATP-grasp domain.


Pssm-ID: 460438  Cd Length: 97  Bit Score: 197.87  E-value: 1.59e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   115 VLLVIDEPHTDWAKYFKGKKIHGEIDIKVEQAEFSDLNLVAHANGGFSVDMEVLRNGVKVVRSLKPDFVLIRQHAFsmAR 194
Cdd:pfam02078   2 TLLVIDDQHTDWSKYFRGKKIHGDYDIRVEQAEFSELNLTAYADGGCVVDMQVIRNGTKVVRSFRPDFVLVRQHAR--DA 79

                          90
                  ....*....|....*...
gi 19924099   195 NGDYRSLVIGLQYAGIPS 212
Cdd:pfam02078  80 GEDYRNLLLGLQYGGVPS 97
Synapsin_N pfam10581
Synapsin N-terminal; This highly conserved domain of synapsin proteins has a serine at ...
 1-27 1.49e-11

Synapsin N-terminal; This highly conserved domain of synapsin proteins has a serine at position 9 or 10 which is a phosphorylation site. The domain appears to be the part of the molecule that binds to calmodulin.


Pssm-ID: 463155  Cd Length: 32  Bit Score: 59.43  E-value: 1.49e-11
                          10        20
                  ....*....|....*....|....*..
gi 19924099     1 MNYLRRRLSDSNFMANLPNGYMTDLQR 27
Cdd:pfam10581   1 MNYLRRRLSDSNFMSNLPNGYMSDLQR 27
LysX COG0189
Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport ...
 161-420 5.52e-10

Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport and metabolism, Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis, Secondary metabolites biosynthesis, transport and catabolism]; Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 439959 [Multi-domain]  Cd Length: 289  Bit Score: 61.11  E-value: 5.52e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099 161 FSVDMEVLRNGVKVVRSLKPDFVLIRQ----HAFSMARNgdyrslvigLQYAGIPSVNSLHSVYNFCDKpwvFAQMVRLH 236
Cdd:COG0189  38 LTLDLGRAPELYRGEDLSEFDAVLPRIdppfYGLALLRQ---------LEAAGVPVVNDPEAIRRARDK---LFTLQLLA 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099 237 KK-LGTeefP--LIdqTFYPNH-KEMLSSTTYPVVVKMGHAHSGMGKVKVDNQHDFQD-IASVVALTKTYATAEPFIDAK 311
Cdd:COG0189 106 RAgIPV---PptLV--TRDPDDlRAFLEELGGPVVLKPLDGSGGRGVFLVEDEDALESiLEALTELGSEPVLVQEFIPEE 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099 312 --YDVRVqkI---GQNYKAYMRTSVSGNWKTNT---GSAmlEQIAMSDRYKLWVDTCSEIFgGLDICAVEALHGKDGRdH 383
Cdd:COG0189 181 dgRDIRV--LvvgGEPVAAIRRIPAEGEFRTNLargGRA--EPVELTDEERELALRAAPAL-GLDFAGVDLIEDDDGP-L 254

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 19924099 384 IIEVvgSSMPLIGDHQDEDKQLIVELVVNKMAQALPR 420
Cdd:COG0189 255 VLEV--NVTPGFRGLERATGVDIAEAIADYLEARAAR 289
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 494-686 2.45e-08

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 57.30  E-value: 2.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099  494 SGLGPPAGSPLPQRLPSPT--SAPQQPASQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRqtsvSG 571
Cdd:PRK07764 592 PGAAGGEGPPAPASSGPPEeaARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDG----GD 667

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099  572 PAPPKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGPGPAGRPKPQlAQKPSQDVPPPATAA 651
Cdd:PRK07764 668 GWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAP-SPAADDPVPLPPEPD 746

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 19924099  652 AGGPPHPQLNKSQSLTNAFNLPEPAPPRPSLSQDE 686
Cdd:PRK07764 747 DPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSE 781
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 505-682 5.01e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 50.15  E-value: 5.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   505 PQRLPSPTSaPQQPASQAAPPTQGqgrqsrpvaggpgappaarppaspspqrqagPPQATRQTSVSGPAPPKASGAPPGG 584
Cdd:pfam03154 239 PQRLPSPHP-PLQPMTQPPPPSQV-------------------------------SPQPLPQPSLHGQMPPMPHSLQTGP 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   585 QQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGPGPAGRPKPQL---------AQKPSQDVPPPATAAAGGP 655
Cdd:pfam03154 287 SHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQppreqplppAPLSMPHIKPPPTTPIPQL 366

                         170       180       190
                  ....*....|....*....|....*....|
gi 19924099   656 PHPQLNKSQSLTNA---FNLPEPAPPRPSL 682
Cdd:pfam03154 367 PNPQSHKHPPHLSGpspFQMNSNLPPPPAL 396
rimK_fam TIGR00768
alpha-L-glutamate ligase, RimK family; This family, related to bacterial glutathione ...
 179-396 3.68e-04

alpha-L-glutamate ligase, RimK family; This family, related to bacterial glutathione synthetases, contains at least three different alpha-L-glutamate ligases. One is RimK, as in E. coli, which adds additional Glu residues to the native Glu-Glu C-terminus of ribosomal protein S6, but not to Lys-Glu mutants. Most species with a member of this subfamily lack an S6 homolog ending in Glu-Glu, however. Members in Methanococcus jannaschii act instead as a tetrahydromethanopterin:alpha-l-glutamate ligase (MJ0620) and a gamma-F420-2:alpha-l-glutamate ligase (MJ1001).


Pssm-ID: 273261 [Multi-domain]  Cd Length: 276  Bit Score: 43.10  E-value: 3.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   179 KPDFVLIR----QHAFSMARNgdyrslvigLQYAGIPSVNSLHSVYNFCDKPWVFAqmvrlhkKLGTEEFPLIDQTFYPN 254
Cdd:TIGR00768  48 ELDVVIVRivsmFRGLAVLRY---------LESLGVPVINSSDAILNAGDKFLSHQ-------LLAKAGIPLPRTGLAGS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   255 HKE---MLSSTTYPVVVKMGHAHSGMGKVKVDnqhDFQDIASVV-ALTKTYATAEPFIDAKY-------DVRVQKIGQNY 323
Cdd:TIGR00768 112 PEEalkLIEEIGFPVVLKPVFGSWGRGVSLAR---DRQAAESLLeHFEQLNGPQNLFLVQEYikkpggrDIRVFVVGDEV 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   324 KAYMRTSVSGNWKTNT---GSAM-------LEQIAMSdryklwvdtCSEIFgGLDICAVEALHGKDGrdHIIEVVGSSMP 393
Cdd:TIGR00768 189 VAAIYRITSGHWRSNLargGKAEpcslteeIEELAIK---------AAKAL-GLDVAGVDLLESEDG--LLVNEVNANPE 256


                  ...
gi 19924099   394 LIG 396
Cdd:TIGR00768 257 FKN 259
SPT5 COG5164
Transcription elongation factor SPT5 [Transcription];
494-681 3.11e-03

Transcription elongation factor SPT5 [Transcription];


Pssm-ID: 444063 [Multi-domain]  Cd Length: 495  Bit Score: 40.78  E-value: 3.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099 494 SGLGPP--AGSPLPQRLPSPTSAPQQPASQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQ-ATRQTSVS 570
Cdd:COG5164  61 GGTRPAgnQGATGPAQNQGGTTPAQNQGGTRPAGNTGGTTPAGDGGATGPPDDGGATGPPDDGGSTTPPSGgSTTPPGDG 140

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099 571 GPAPPKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGP-GPAGRPKPQLAQKPSQD---VPP 646
Cdd:COG5164 141 GSTPPGPGSTGPGGSTTPPGDGGSTTPPGPGGSTTPPDDGGSTTPPNKGETGTDIPtGGTPRQGPDGPVKKDDKngkGNP 220

                       170       180       190
                ....*....|....*....|....*....|....*
gi 19924099 647 PATAAAGGPPHPQLNKSQSLTNAFNLPEPAPPRPS 681
Cdd:COG5164 221 PDDRGGKTGPKDQRPKTNPIERRGPERPEAAALPA 255
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 555-677 8.85e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 39.40  E-value: 8.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   555 QRQAGPPQAtRQTSVSGPAPPkASGAPPGGQQRqgppqkppgpagptrQASQAGPVPRTGPptTQQPRPSGPGPAGRPKP 634
Cdd:TIGR01628 374 QFMQLQPRM-RQLPMGSPMGG-AMGQPPYYGQG---------------PQQQFNGQPLGWP--RMSMMPTPMGPGGPLRP 434

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 19924099   635 Q-LAQKPSQDVPP----PATAAAGGPPHPQLNKSQSLTNAFNLPEPAP 677
Cdd:TIGR01628 435 NgLAPMNAVRAPSrnaqNAAQKPPMQPVMYPPNYQSLPLSQDLPQPQS 482
 
Name Accession Description Interval E-value
Synapsin_C pfam02750
Synapsin, ATP binding domain; Ca dependent ATP binding in this ATP grasp fold. Function ...
 214-416 1.76e-137

Synapsin, ATP binding domain; Ca dependent ATP binding in this ATP grasp fold. Function unknown.


Pssm-ID: 308403  Cd Length: 203  Bit Score: 401.74  E-value: 1.76e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   214 NSLHSVYNFCDKPWVFAQMVRLHKKLGTEEFPLIDQTFYPNHKEMLSSTTYPVVVKMGHAHSGMGKVKVDNQHDFQDIAS 293
Cdd:pfam02750   1 NSLESIYNFCDKPWVFAQLIAIFHSLGGEKFPLIEQTFFPNHKEMLTAPNFPVVIKIGHAHAGMGKIKVENHHDFQDIAS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   294 VVALTKTYATAEPFIDAKYDVRVQKIGQNYKAYMRTSVSGNWKTNTGSAMLEQIAMSDRYKLWVDTCSEIFGGLDICAVE 373
Cdd:pfam02750  81 VVALAKTYATAEAFIDSKYDIRIQKIGNNYKAYMRTSISGNWKANTGSAMLEQIAMSDRYKLWVDSCSEMFGGLDICAVK 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 19924099   374 ALHGKDGRDHIIEVVGSSMPLIGDHQDEDKQLIVELVVNKMAQ 416
Cdd:pfam02750 161 AVHGKDGKDYIFEVMDCSMPLIGEHQEEDKQLIADLVISKMNQ 203
Synapsin pfam02078
Synapsin, N-terminal domain; This family is structurally related to the PreATP-grasp domain.
 115-212 1.59e-60

Synapsin, N-terminal domain; This family is structurally related to the PreATP-grasp domain.


Pssm-ID: 460438  Cd Length: 97  Bit Score: 197.87  E-value: 1.59e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   115 VLLVIDEPHTDWAKYFKGKKIHGEIDIKVEQAEFSDLNLVAHANGGFSVDMEVLRNGVKVVRSLKPDFVLIRQHAFsmAR 194
Cdd:pfam02078   2 TLLVIDDQHTDWSKYFRGKKIHGDYDIRVEQAEFSELNLTAYADGGCVVDMQVIRNGTKVVRSFRPDFVLVRQHAR--DA 79

                          90
                  ....*....|....*...
gi 19924099   195 NGDYRSLVIGLQYAGIPS 212
Cdd:pfam02078  80 GEDYRNLLLGLQYGGVPS 97
Synapsin_N pfam10581
Synapsin N-terminal; This highly conserved domain of synapsin proteins has a serine at ...
 1-27 1.49e-11

Synapsin N-terminal; This highly conserved domain of synapsin proteins has a serine at position 9 or 10 which is a phosphorylation site. The domain appears to be the part of the molecule that binds to calmodulin.


Pssm-ID: 463155  Cd Length: 32  Bit Score: 59.43  E-value: 1.49e-11
                          10        20
                  ....*....|....*....|....*..
gi 19924099     1 MNYLRRRLSDSNFMANLPNGYMTDLQR 27
Cdd:pfam10581   1 MNYLRRRLSDSNFMSNLPNGYMSDLQR 27
LysX COG0189
Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport ...
 161-420 5.52e-10

Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily [Amino acid transport and metabolism, Coenzyme transport and metabolism, Translation, ribosomal structure and biogenesis, Secondary metabolites biosynthesis, transport and catabolism]; Glutathione synthase, LysX or RimK-type ligase, ATP-grasp superfamily is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 439959 [Multi-domain]  Cd Length: 289  Bit Score: 61.11  E-value: 5.52e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099 161 FSVDMEVLRNGVKVVRSLKPDFVLIRQ----HAFSMARNgdyrslvigLQYAGIPSVNSLHSVYNFCDKpwvFAQMVRLH 236
Cdd:COG0189  38 LTLDLGRAPELYRGEDLSEFDAVLPRIdppfYGLALLRQ---------LEAAGVPVVNDPEAIRRARDK---LFTLQLLA 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099 237 KK-LGTeefP--LIdqTFYPNH-KEMLSSTTYPVVVKMGHAHSGMGKVKVDNQHDFQD-IASVVALTKTYATAEPFIDAK 311
Cdd:COG0189 106 RAgIPV---PptLV--TRDPDDlRAFLEELGGPVVLKPLDGSGGRGVFLVEDEDALESiLEALTELGSEPVLVQEFIPEE 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099 312 --YDVRVqkI---GQNYKAYMRTSVSGNWKTNT---GSAmlEQIAMSDRYKLWVDTCSEIFgGLDICAVEALHGKDGRdH 383
Cdd:COG0189 181 dgRDIRV--LvvgGEPVAAIRRIPAEGEFRTNLargGRA--EPVELTDEERELALRAAPAL-GLDFAGVDLIEDDDGP-L 254

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 19924099 384 IIEVvgSSMPLIGDHQDEDKQLIVELVVNKMAQALPR 420
Cdd:COG0189 255 VLEV--NVTPGFRGLERATGVDIAEAIADYLEARAAR 289
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 494-686 2.45e-08

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 57.30  E-value: 2.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099  494 SGLGPPAGSPLPQRLPSPT--SAPQQPASQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRqtsvSG 571
Cdd:PRK07764 592 PGAAGGEGPPAPASSGPPEeaARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDG----GD 667

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099  572 PAPPKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGPGPAGRPKPQlAQKPSQDVPPPATAA 651
Cdd:PRK07764 668 GWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAP-SPAADDPVPLPPEPD 746

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 19924099  652 AGGPPHPQLNKSQSLTNAFNLPEPAPPRPSLSQDE 686
Cdd:PRK07764 747 DPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSE 781
PHA03247 PHA03247
large tegument protein UL36; Provisional
 419-681 3.11e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 3.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   419 PRQRQRDASPGRGSHGQTPSPGALPLGRQTSQQPAGPPAQQRPPPQGGPPQPGPGPQRQGpplqqrpppqgqqhlsglGP 498
Cdd:PHA03247 2571 PRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPS------------------PS 2632

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   499 PAGSPLPQRLPSPTSAPQQPASQAAPPtqgqgRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPAPPKAS 578
Cdd:PHA03247 2633 PAANEPDPHPPPTVPPPERPRDDPAPG-----RVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPT 2707

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   579 GAP-PGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGP-----PTTQQPRPSGPGPAGRPKPQLAQKPSQDVPPPATAAA 652
Cdd:PHA03247 2708 PEPaPHALVSATPLPPGPAAARQASPALPAAPAPPAVPagpatPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPA 2787

                         250       260
                  ....*....|....*....|....*....
gi 19924099   653 GGPPHPQLNKSQSLTNAFNLPEPAPPRPS 681
Cdd:PHA03247 2788 VASLSESRESLPSPWDPADPPAAVLAPAA 2816
PHA03247 PHA03247
large tegument protein UL36; Provisional
 419-683 2.15e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 2.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   419 PRQRQRDASPG--RGSHGQTPSPGALPLGRQTSQQPAgppaqqrpppQGGPPQPGPGPQRQGPPLQQRPPPQGQQHLSGL 496
Cdd:PHA03247 2592 PPQSARPRAPVddRGDPRGPAPPSPLPPDTHAPDPPP----------PSPSPAANEPDPHPPPTVPPPERPRDDPAPGRV 2661

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   497 GPPAGSPLPQRLPSPTSAPQQPASQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGpPQATRQTSVS---GPA 573
Cdd:PHA03247 2662 SRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPG-PAAARQASPAlpaAPA 2740

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   574 PPKASGAP--PGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQP----RPSGPGP-AGRPKPQLAQKPSQDVPP 646
Cdd:PHA03247 2741 PPAVPAGPatPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASlsesRESLPSPwDPADPPAAVLAPAAALPP 2820

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 19924099   647 PATAAAGGPPHPqlnksqSLTNAFNLPEPAPPRPSLS 683
Cdd:PHA03247 2821 AASPAGPLPPPT------SAQPTAPPPPPGPPPPSLP 2851
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 505-682 5.01e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 50.15  E-value: 5.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   505 PQRLPSPTSaPQQPASQAAPPTQGqgrqsrpvaggpgappaarppaspspqrqagPPQATRQTSVSGPAPPKASGAPPGG 584
Cdd:pfam03154 239 PQRLPSPHP-PLQPMTQPPPPSQV-------------------------------SPQPLPQPSLHGQMPPMPHSLQTGP 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   585 QQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGPGPAGRPKPQL---------AQKPSQDVPPPATAAAGGP 655
Cdd:pfam03154 287 SHMQHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQppreqplppAPLSMPHIKPPPTTPIPQL 366

                         170       180       190
                  ....*....|....*....|....*....|
gi 19924099   656 PHPQLNKSQSLTNA---FNLPEPAPPRPSL 682
Cdd:pfam03154 367 PNPQSHKHPPHLSGpspFQMNSNLPPPPAL 396
PHA03247 PHA03247
large tegument protein UL36; Provisional
 497-696 7.06e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.94  E-value: 7.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   497 GPPAGSPLPQRLPSPTSAPQQPASQAAP-PTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTS-VSGPAP 574
Cdd:PHA03247 2606 GDPRGPAPPSPLPPDTHAPDPPPPSPSPaANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSpPQRPRR 2685

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   575 PKASG--APPGGQQRQGPPQKPPGPAGptRQASQAGPVPrTGPPTTQQPRPSGP-GPAGRPKPQLAQKPSQDVPPPATAA 651
Cdd:PHA03247 2686 RAARPtvGSLTSLADPPPPPPTPEPAP--HALVSATPLP-PGPAAARQASPALPaAPAPPAVPAGPATPGGPARPARPPT 2762

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 19924099   652 AGGPPHPQLNKSQSLTnafnlPEPAPPRPSLSQDEVKAETIRSLR 696
Cdd:PHA03247 2763 TAGPPAPAPPAAPAAG-----PPRRLTRPAVASLSESRESLPSPW 2802
PHA03247 PHA03247
large tegument protein UL36; Provisional
 498-681 9.91e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.17  E-value: 9.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   498 PPAGSPLPQRLPSPTSAPQQPASQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGP--PQATRQTSVSGPAPP 575
Cdd:PHA03247 2813 APAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPaaPARPPVRRLARPAVS 2892

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   576 KASGA---PPGGQQRQGppqkppGpagptrqaSQAGPVPRTGPPTTQQPRPS-GPGPAGRPKPQLAQKPSqdvPPPATAA 651
Cdd:PHA03247 2893 RSTESfalPPDQPERPP------Q--------PQAPPPPQPQPQPPPPPQPQpPPPPPPRPQPPLAPTTD---PAGAGEP 2955

                         170       180       190
                  ....*....|....*....|....*....|...
gi 19924099   652 AGGPPHPQLNKSQSLTNA---FNLPEPAPPRPS 681
Cdd:PHA03247 2956 SGAVPQPWLGALVPGRVAvprFRVPQPAPSREA 2988
PHA03247 PHA03247
large tegument protein UL36; Provisional
 498-684 1.75e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.40  E-value: 1.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   498 PPAGSPLPQRLPSPTSAPQQPASQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGP----------------P 561
Cdd:PHA03247 2734 ALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESREslpspwdpadppaavlA 2813

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   562 QATRQTSVSGPAPPKASgaPPGGQQRQGPPQKPPGPAGPTRQASQA--GPVPRTGPPTTQQPRPSGPG--PAGR-PKPQL 636
Cdd:PHA03247 2814 PAAALPPAASPAGPLPP--PTSAQPTAPPPPPGPPPPSLPLGGSVApgGDVRRRPPSRSPAAKPAAPArpPVRRlARPAV 2891

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 19924099   637 AQKP-SQDVPPPATAAAGGPPHPQLNKSQSLTNAFNLPEPAPPRPSLSQ 684
Cdd:PHA03247 2892 SRSTeSFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQ 2940
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
498-685 7.53e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 46.02  E-value: 7.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099  498 PPAGSPLPQRLPSPTSAPQQPAS--QAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPAPP 575
Cdd:PRK12323 386 APAAAAPAAAAPAPAAPPAAPAAapAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPA 465

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099  576 KASGAPPGgqqrqgppQKPPGPAGPTRQASQAGPVPRTGPPTTQQP--------RPSGPGPAGRPKPQLAQKPSQDVPPP 647
Cdd:PRK12323 466 AAGPRPVA--------AAAAAAPARAAPAAAPAPADDDPPPWEELPpefaspapAQPDAAPAGWVAESIPDPATADPDDA 537

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 19924099  648 ATAAAGGPPHPQLNKSQSLTNafnlPEPAPPRPSLSQD 685
Cdd:PRK12323 538 FETLAPAPAAAPAPRAAAATE----PVVAPRPPRASAS 571
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 556-695 7.76e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.32  E-value: 7.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   556 RQAGPPQATRQTSVSGPAPPKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPrtGPPTTQQPRPSGPGPAGRPKPQ 635
Cdd:PHA03307  773 ALLEPAEPQRGAGSSPPVRAEAAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDG--GSESSGPARPPGAAARPPPARS 850

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19924099   636 LAQKPSQDVPPPATAAAGGP---PHPQLNKSQSLTNAFNLPEPAPPRPSLSQDEVKAETIRSL 695
Cdd:PHA03307  851 SESSKSKPAAAGGRARGKNGrrrPRPPEPRARPGAAAPPKAAAAAPPAGAPAPRPRPAPRVKL 913
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 504-660 8.85e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 45.75  E-value: 8.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099  504 LPQRLPSPTSApQQPASQAAPPTQGQGRQSrpvaggpgappaarpPASPSPQ-RQAGPPQATRQTSVSGPAPPKASGAPP 582
Cdd:PRK07764 374 LLARLERLERR-LGVAGGAGAPAAAAPSAA---------------AAAPAAApAPAAAAPAAAAAPAPAAAPQPAPAPAP 437

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19924099  583 GGQQRQGPPQKPPGPAGPTRQASQAGPVPRtgpPTTQQPRPSGPGPAGRPKPQLAQKPSQDVPPPATAAAGGPPHPQL 660
Cdd:PRK07764 438 APAPPSPAGNAPAGGAPSPPPAAAPSAQPA---PAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATL 512
PHA03378 PHA03378
EBNA-3B; Provisional
 499-669 1.65e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 45.06  E-value: 1.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099  499 PAGSPLPQRLPSPTSAPQQPASQAAPPTQGQGRqSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPAPPKAs 578
Cdd:PHA03378 691 PGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGR-ARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPA- 768

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099  579 gAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGPGPAGRPKPQLAQ---------KPSQDVPPPAT 649
Cdd:PHA03378 769 -AAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGPTSMQLMPRAAPGQQGPTKQILRQlltggvkrgRPSLKKPAALE 847

                        170       180
                 ....*....|....*....|..
gi 19924099  650 --AAAGGPPHPQLNKSQSLTNA 669
Cdd:PHA03378 848 rqAAAGPTPSPGSGTSDKIVQA 869
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 565-695 1.77e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.98  E-value: 1.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099  565 RQTSVSGPAPPkASGAPPGGQQRQGPPQKPPGP-----AGPTRQASQAGPVPrtGPPTTQQPRPSGPGPAGRPKPQLAQK 639
Cdd:PRK07764 383 RRLGVAGGAGA-PAAAAPSAAAAAPAAAPAPAAaapaaAAAPAPAAAPQPAP--APAPAPAPPSPAGNAPAGGAPSPPPA 459

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 19924099  640 PSQDVPPPATAAAGGPPHPQLNKSQSLTNAFNLPEPAPPRPSLSQDEVKAETIRSL 695
Cdd:PRK07764 460 AAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATLRER 515
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
515-686 2.10e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.48  E-value: 2.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099  515 PQQPASQAAPPTQGQGRQSRPVAGGPGAppaarppaspspqrQAGPPQATRQTSVSGPAPPKASGAPPGGQQrQGPPQKP 594
Cdd:PRK12323 365 PGQSGGGAGPATAAAAPVAQPAPAAAAP--------------AAAAPAPAAPPAAPAAAPAAAAAARAVAAA-PARRSPA 429

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099  595 PGPAGPTRQASQAGPVPRTGPPTTQqprPSGPGPAGRPK-PQLAQKPSQDVPPPATAAAGGPPHPQLNKS---QSLTNAF 670
Cdd:PRK12323 430 PEALAAARQASARGPGGAPAPAPAP---AAAPAAAARPAaAGPRPVAAAAAAAPARAAPAAAPAPADDDPppwEELPPEF 506

                        170
                 ....*....|....*.
gi 19924099  671 NLPEPAPPRPSLSQDE 686
Cdd:PRK12323 507 ASPAPAQPDAAPAGWV 522
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 575-694 3.30e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.21  E-value: 3.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099  575 PKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGPGPAGRPKPQLAQKPSQDVPPPATAAAGG 654
Cdd:PRK07764 365 PSASDDERGLLARLERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSP 444

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 19924099  655 PPHPQLNKSQSltnafNLPEPAPPRPSLSQDEVKAETIRS 694
Cdd:PRK07764 445 AGNAPAGGAPS-----PPPAAAPSAQPAPAPAAAPEPTAA 479
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 498-646 3.43e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 44.31  E-value: 3.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   498 PPAGSPLPQRLPSPTSAPQQPasQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPAPPKa 577
Cdd:PRK10263  364 PGPQTGEPVIAPAPEGYPQQS--QYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQ- 440

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   578 sgaPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGPGPAGRPKPQLAQ-KPSQdvPP 646
Cdd:PRK10263  441 ---PVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEPLYQQPQPVEQQPVVEPEPVVEEtKPAR--PP 505
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 566-693 3.46e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 43.70  E-value: 3.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099  566 QTSVSGPAPPKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPrTGPPTTQQPRPSGPGPAGRPkpQLAQKPSQDVP 645
Cdd:PRK07994 362 AAPLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAP-QQAPAVPLPETTSQLLAARQ--QLQRAQGATKA 438

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 19924099  646 PPATAAAGGPPHPQLNKSQSLTNAFNLPEPAPPRPslsqdeVKAETIR 693
Cdd:PRK07994 439 KKSEPAAASRARPVNSALERLASVRPAPSALEKAP------AKKEAYR 480
rimK_fam TIGR00768
alpha-L-glutamate ligase, RimK family; This family, related to bacterial glutathione ...
 179-396 3.68e-04

alpha-L-glutamate ligase, RimK family; This family, related to bacterial glutathione synthetases, contains at least three different alpha-L-glutamate ligases. One is RimK, as in E. coli, which adds additional Glu residues to the native Glu-Glu C-terminus of ribosomal protein S6, but not to Lys-Glu mutants. Most species with a member of this subfamily lack an S6 homolog ending in Glu-Glu, however. Members in Methanococcus jannaschii act instead as a tetrahydromethanopterin:alpha-l-glutamate ligase (MJ0620) and a gamma-F420-2:alpha-l-glutamate ligase (MJ1001).


Pssm-ID: 273261 [Multi-domain]  Cd Length: 276  Bit Score: 43.10  E-value: 3.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   179 KPDFVLIR----QHAFSMARNgdyrslvigLQYAGIPSVNSLHSVYNFCDKPWVFAqmvrlhkKLGTEEFPLIDQTFYPN 254
Cdd:TIGR00768  48 ELDVVIVRivsmFRGLAVLRY---------LESLGVPVINSSDAILNAGDKFLSHQ-------LLAKAGIPLPRTGLAGS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   255 HKE---MLSSTTYPVVVKMGHAHSGMGKVKVDnqhDFQDIASVV-ALTKTYATAEPFIDAKY-------DVRVQKIGQNY 323
Cdd:TIGR00768 112 PEEalkLIEEIGFPVVLKPVFGSWGRGVSLAR---DRQAAESLLeHFEQLNGPQNLFLVQEYikkpggrDIRVFVVGDEV 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   324 KAYMRTSVSGNWKTNT---GSAM-------LEQIAMSdryklwvdtCSEIFgGLDICAVEALHGKDGrdHIIEVVGSSMP 393
Cdd:TIGR00768 189 VAAIYRITSGHWRSNLargGKAEpcslteeIEELAIK---------AAKAL-GLDVAGVDLLESEDG--LLVNEVNANPE 256


                  ...
gi 19924099   394 LIG 396
Cdd:TIGR00768 257 FKN 259
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 505-642 5.04e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 43.49  E-value: 5.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   505 PQRLPSPTSAPQQPAsQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQA-TRQTSvSGPAPPKASGAPPG 583
Cdd:pfam09770 208 KKPAQQPAPAPAQPP-AAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTIlQRPQS-PQPDPAQPSIQPQA 285

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19924099   584 GQQRQGPPQKPPG---------PAGPTRQASQAGPVPRTGPPTTQQPRPSGPGpAGRPKPQLAQkPSQ 642
Cdd:pfam09770 286 QQFHQQPPPVPVQptqilqnpnRLSAARVGYPQNPQPGVQPAPAHQAHRQQGS-FGRQAPIITH-PQQ 351
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 497-659 5.55e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.44  E-value: 5.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099  497 GPPAGSPLPQRLPSPTSAPQQPASQAAPPTQGQGRQSRPVAGGPGAPPAA---------RPPASPSPQRQAGPPQATRQT 567
Cdd:PRK07764 627 PAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAapaapppapAPAAPAAPAGAAPAQPAPAPA 706

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099  568 SVSGPAP-PKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGPGPAGRPKPQLAQKPSQDVPP 646
Cdd:PRK07764 707 ATPPAGQaDDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMA 786

                        170
                 ....*....|...
gi 19924099  647 PATAAAGGPPHPQ 659
Cdd:PRK07764 787 EDDAPSMDDEDRR 799
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 495-626 7.30e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.05  E-value: 7.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099  495 GLGPPAGSPLPQRLPSPTSAPQQPASQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPAP 574
Cdd:PRK07764 386 GVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQ 465

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 19924099  575 PKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGP 626
Cdd:PRK07764 466 PAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATLRERWP 517
PHA03378 PHA03378
EBNA-3B; Provisional
 432-681 9.17e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 42.75  E-value: 9.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099  432 SHGQTPSPgaLPLGRQTSQQPAgppaQQRPPPQGGPPQPGPGPQRQGPPLQQRPPPQGQQHLSGLGP---PAGSPLPQRL 508
Cdd:PHA03378 591 SYAQTPWP--VPHPSQTPEPPT----TQSHIPETSAPRQWPMPLRPIPMRPLRMQPITFNVLVFPTPhqpPQVEITPYKP 664

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099  509 -----------PSPTSA-----PQQPASQAAPPTQGQGRqSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGP 572
Cdd:PHA03378 665 twtqighipyqPSPTGAntmlpIQWAPGTMQPPPRAPTP-MRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGR 743

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099  573 APPKAsgAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRpsgPGPAGRPKPQLAQKPSQdVPPPATAAA 652
Cdd:PHA03378 744 ARPPA--AAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPR---GAPTPQPPPQAGPTSMQ-LMPRAAPGQ 817

                        250       260
                 ....*....|....*....|....*....
gi 19924099  653 GGPPHPQLNksQSLTNAFNLPEPAPPRPS 681
Cdd:PHA03378 818 QGPTKQILR--QLLTGGVKRGRPSLKKPA 844
PHA03247 PHA03247
large tegument protein UL36; Provisional
 415-684 1.19e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   415 AQALPRQRQRDASPGRGSHGQTPSPGALPLGRQTSQQPAGPPAQQRPPPQGGPPQPGPGPQRQGPPLQQRPPPQGQQHLS 494
Cdd:PHA03247 2747 GPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAG 2826

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   495 GLGPP-AGSPLPQRLPSPTSAPQQPASQAAPPtqgqGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPA 573
Cdd:PHA03247 2827 PLPPPtSAQPTAPPPPPGPPPPSLPLGGSVAP----GGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPP 2902

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   574 PPKASGAPPGGQQR---QGPPQKPPGPAGPTRQA--SQAGPVPRTGPPTTQQPRPSGPGP-AGRPKPQLAQKPSQDVPPP 647
Cdd:PHA03247 2903 DQPERPPQPQAPPPpqpQPQPPPPPQPQPPPPPPprPQPPLAPTTDPAGAGEPSGAVPQPwLGALVPGRVAVPRFRVPQP 2982

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 19924099   648 A----TAAAGGPPHPQLNKSQSLTNAFNLP---EPAPPRPSLSQ 684
Cdd:PHA03247 2983 ApsreAPASSTPPLTGHSLSRVSSWASSLAlheETDPPPVSLKQ 3026
PHA03247 PHA03247
large tegument protein UL36; Provisional
 500-702 1.24e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 1.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   500 AGSPLPqrLPSPTSAPQQPASQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPAPPKASg 579
Cdd:PHA03247  303 AGAPLA--LPAPPDPPPPAPAGDAEEEDDEDGAMEVVSPLPRPRQHYPLGFPKRRRPTWTPPSSLEDLSAGRHHPKRAS- 379

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   580 aPPGGQQRQgppqkppgpagpTRQAsqAGPVPRtGPPTTQQPRPSGPGPAGRPKPqlaqkpsqdVPPPATAAAGGPPHPQ 659
Cdd:PHA03247  380 -LPTRKRRS------------ARHA--ATPFAR-GPGGDDQTRPAAPVPASVPTP---------APTPVPASAPPPPATP 434

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 19924099   660 LNKSQSLTNAFNLPEPAPPRPSLSQDEVKAETIRSLRKSFASL 702
Cdd:PHA03247  435 LPSAEPGSDDGPAPPPERQPPAPATEPAPDDPDDATRKALDAL 477
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
510-680 1.25e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.17  E-value: 1.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099  510 SPTSAPQQPASQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQrQAGPPQATRQTSVSGPAPPKASGAPPGGQQRQG 589
Cdd:PRK12323 373 GPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARA-VAAAPARRSPAPEALAAARQASARGPGGAPAPA 451

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099  590 PPQKPPGPAGPTRQASQAGPVPRTGPPTtqqprPSGPGPAGRPKPQLAQKPSQDVPPPATAAAgGPPHPQLNKSQSLTNA 669
Cdd:PRK12323 452 PAPAAAPAAAARPAAAGPRPVAAAAAAA-----PARAAPAAAPAPADDDPPPWEELPPEFASP-APAQPDAAPAGWVAES 525

                        170
                 ....*....|.
gi 19924099  670 FNLPEPAPPRP 680
Cdd:PRK12323 526 IPDPATADPDD 536
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
494-691 1.34e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 42.14  E-value: 1.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099  494 SGLGPPAGSPLPQRLPSPTSAPQQPASQAAPPTQGQGRQSRPVAGgpgappaarppaspspqrqAGPPQATRQTSVSGPA 573
Cdd:PRK07003 364 GGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGA-------------------ALAPKAAAAAAATRAE 424

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099  574 PPKASGAPPGGQ---QRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGPGPAGRPKPQLAQKPSQDVPPPATA 650
Cdd:PRK07003 425 APPAAPAPPATAdrgDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATP 504

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 19924099  651 AAGGPPHPqlnkSQSLTNAFNLPEPAPPRPSLSQDEVKAET 691
Cdd:PRK07003 505 AAVPDARA----PAAASREDAPAAAAPPAPEARPPTPAAAA 541
PHA03247 PHA03247
large tegument protein UL36; Provisional
 556-684 1.64e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   556 RQAGPPQATRQTSVSGPAPpkaSGAPPGGQQRQGPPQKPPGPAGptrqASQAGPVPRTGPPTTQQPRPSG--PGPAGRPK 633
Cdd:PHA03247  376 KRASLPTRKRRSARHAATP---FARGPGGDDQTRPAAPVPASVP----TPAPTPVPASAPPPPATPLPSAepGSDDGPAP 448

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 19924099   634 PQLAQkpsqdvpPPATAAAGGPPHPQLNKSQSLTNAFNLPEPAPPRPSLSQ 684
Cdd:PHA03247  449 PPERQ-------PPAPATEPAPDDPDDATRKALDALRERRPPEPPGADLAE 492
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 558-681 1.66e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 41.59  E-value: 1.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099  558 AGPPQATrqtSVSGPAPPKASGAPPGGQQRQGPPqkppgpagptrqASQAGPVPRTGPPTTqqprpsgPGPAGRPKPQLa 637
Cdd:PRK14959 378 ASAPSGS---AAEGPASGGAATIPTPGTQGPQGT------------APAAGMTPSSAAPAT-------PAPSAAPSPRV- 434

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 19924099  638 qkPSQDVpPPATAAAGGPPHPqlnksqsltnAFNLPE--PAPPRPS 681
Cdd:PRK14959 435 --PWDDA-PPAPPRSGIPPRP----------APRMPEasPVPGAPD 467
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 497-688 1.80e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 41.70  E-value: 1.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   497 GPPAGSPLPQRLPSPTSAPQQPASQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTSVSGPAPPK 576
Cdd:PHA03307   74 GPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPP 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   577 ASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGPGPAGRPKPQLAQKPSQDVP-PPATAAAGGP 655
Cdd:PHA03307  154 AAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPaPGRSAADDAG 233

                         170       180       190
                  ....*....|....*....|....*....|...
gi 19924099   656 PHPQLNKSQSLTNAFNLPEPAPPRPSLSQDEVK 688
Cdd:PHA03307  234 ASSSDSSSSESSGCGWGPENECPLPRPAPITLP 266
dnaA PRK14086
chromosomal replication initiator protein DnaA;
498-661 2.44e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 40.96  E-value: 2.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099  498 PPAGSPLPQRLPSPTSA-------PQQPASQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGP--PQATRQTS 568
Cdd:PRK14086  95 PAPPPPHARRTSEPELPrpgrrpyEGYGGPRADDRPPGLPRQDQLPTARPAYPAYQQRPEPGAWPRAADDygWQQQRLGF 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099  569 VSgPAPPKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGPP---TTQQPRPS---------GPGPAGRP-KPQ 635
Cdd:PRK14086 175 PP-RAPYASPASYAPEQERDREPYDAGRPEYDQRRRDYDHPRPDWDRPrrdRTDRPEPPpgaghvhrgGPGPPERDdAPV 253

                        170       180
                 ....*....|....*....|....*....
gi 19924099  636 LAQKPSQDVPP---PATAAAGGPPHPQLN 661
Cdd:PRK14086 254 VPIRPSAPGPLaaqPAPAPGPGEPTARLN 282
SPT5 COG5164
Transcription elongation factor SPT5 [Transcription];
494-681 3.11e-03

Transcription elongation factor SPT5 [Transcription];


Pssm-ID: 444063 [Multi-domain]  Cd Length: 495  Bit Score: 40.78  E-value: 3.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099 494 SGLGPP--AGSPLPQRLPSPTSAPQQPASQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQ-ATRQTSVS 570
Cdd:COG5164  61 GGTRPAgnQGATGPAQNQGGTTPAQNQGGTRPAGNTGGTTPAGDGGATGPPDDGGATGPPDDGGSTTPPSGgSTTPPGDG 140

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099 571 GPAPPKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGP-GPAGRPKPQLAQKPSQD---VPP 646
Cdd:COG5164 141 GSTPPGPGSTGPGGSTTPPGDGGSTTPPGPGGSTTPPDDGGSTTPPNKGETGTDIPtGGTPRQGPDGPVKKDDKngkGNP 220

                       170       180       190
                ....*....|....*....|....*....|....*
gi 19924099 647 PATAAAGGPPHPQLNKSQSLTNAFNLPEPAPPRPS 681
Cdd:COG5164 221 PDDRGGKTGPKDQRPKTNPIERRGPERPEAAALPA 255
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 569-658 3.51e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 40.56  E-value: 3.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099  569 VSGPAPPKASGAPPggqQRQGPPQKPPGPAGPTRQASQAGPVPRTGPPTTQQPRPSGPgPAGRPKPQLAQKPSQDVPPPA 648
Cdd:PRK14950 365 APQPAKPTAAAPSP---VRPTPAPSTRPKAAAAANIPPKEPVRETATPPPVPPRPVAP-PVPHTPESAPKLTRAAIPVDE 440

                         90
                 ....*....|
gi 19924099  649 TAAAGGPPHP 658
Cdd:PRK14950 441 KPKYTPPAPP 450
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 555-677 8.85e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 39.40  E-value: 8.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19924099   555 QRQAGPPQAtRQTSVSGPAPPkASGAPPGGQQRqgppqkppgpagptrQASQAGPVPRTGPptTQQPRPSGPGPAGRPKP 634
Cdd:TIGR01628 374 QFMQLQPRM-RQLPMGSPMGG-AMGQPPYYGQG---------------PQQQFNGQPLGWP--RMSMMPTPMGPGGPLRP 434

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 19924099   635 Q-LAQKPSQDVPP----PATAAAGGPPHPQLNKSQSLTNAFNLPEPAP 677
Cdd:TIGR01628 435 NgLAPMNAVRAPSrnaqNAAQKPPMQPVMYPPNYQSLPLSQDLPQPQS 482
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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