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Conserved domains on  [gi|198247443|gb|ACH83036|]
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major facilitator superfamily MFS_1 [Acidithiobacillus ferrooxidans ATCC 53993]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 12-347 3.77e-89

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17472:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 371  Bit Score: 274.09  E-value: 3.77e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  12 LSFIYVARMLGLFMLMPVLALDNDQLRHSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGA 91
Cdd:cd17472    1 LSLIFSLRMLGMFLVLPVLSVYAKSLPGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  92 VTHNIWGIILARLLQGAGAVSSVLLATAGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGLTGVFLVAAALGV 171
Cdd:cd17472   81 YATSIYGLILGRALQGSGAISSVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 172 LALLPLWKVIPPIPRNLQQRMGNWRDALRIFRYPPVLTASVGIFILQMVLGASFVVLsPELVKAMHIPGSAVWEVYLPVM 251
Cdd:cd17472  161 VSLLILLFFVPDPPKIVQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYIL-PLLLTQLGGGKGQLWKVYLPAI 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 252 LLSVAGMLYPVIHAERHRQHGQMLVFSGLAIAAGALFMGLLAGHFWPVAVGAVIFFTGYNVASAILPSMMSRSTTQEQRG 331
Cdd:cd17472  240 LIGFILMVPFVIYAEKKGKMKQVFVSSILLIAVGFLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRG 319

                        330
                 ....*....|....*.
gi 198247443 332 AASGVYSLMQFLGIFA 347
Cdd:cd17472  320 TAMGIYNTSQFLGSFL 335
 
Name Accession Description Interval E-value
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 12-347 3.77e-89

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 274.09  E-value: 3.77e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  12 LSFIYVARMLGLFMLMPVLALDNDQLRHSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGA 91
Cdd:cd17472    1 LSLIFSLRMLGMFLVLPVLSVYAKSLPGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  92 VTHNIWGIILARLLQGAGAVSSVLLATAGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGLTGVFLVAAALGV 171
Cdd:cd17472   81 YATSIYGLILGRALQGSGAISSVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 172 LALLPLWKVIPPIPRNLQQRMGNWRDALRIFRYPPVLTASVGIFILQMVLGASFVVLsPELVKAMHIPGSAVWEVYLPVM 251
Cdd:cd17472  161 VSLLILLFFVPDPPKIVQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYIL-PLLLTQLGGGKGQLWKVYLPAI 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 252 LLSVAGMLYPVIHAERHRQHGQMLVFSGLAIAAGALFMGLLAGHFWPVAVGAVIFFTGYNVASAILPSMMSRSTTQEQRG 331
Cdd:cd17472  240 LIGFILMVPFVIYAEKKGKMKQVFVSSILLIAVGFLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRG 319

                        330
                 ....*....|....*.
gi 198247443 332 AASGVYSLMQFLGIFA 347
Cdd:cd17472  320 TAMGIYNTSQFLGSFL 335
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
2-345 5.67e-36

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 134.72  E-value: 5.67e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443   2 SPFEKRAVAGLSFIYVARMLGLFMLMPVLALDNDQLrHSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLL 81
Cdd:COG2814    5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  82 IFVLGSLLGAVTHNIWGIILARLLQG--AGAVSSVLLATAGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGL 159
Cdd:COG2814   84 LFALGSLLCALAPSLWLLLAARFLQGlgAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 160 TGVFLVAAALGVLALLPLWKVIPPIPRNLQQRMGnwRDALRIFRYPPVLTASVGIFILQMVLGASFVVLSPELVKAMHIP 239
Cdd:COG2814  164 RWVFLVNAVLALLALLLLLRLLPESRPAARARLR--GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLS 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 240 GSAVWEVYLPVMLLSVAGMLYPVIHAERHrqHGQMLVFSGLAIAAGALFMGLLAGHFWPVAVGAVIFFTGYNVASAILPS 319
Cdd:COG2814  242 ASAAGLLLALFGLGGVLGALLAGRLADRF--GRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQA 319

                        330       340
                 ....*....|....*....|....*.
gi 198247443 320 MMSRSTTQEQRGAASGVYSLMQFLGI 345
Cdd:COG2814  320 LVAELAPPEARGRASGLYNSAFFLGG 345
MFS_1 pfam07690
Major Facilitator Superfamily;
12-347 3.14e-27

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 110.59  E-value: 3.14e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443   12 LSFIYVARMLGLFMLMPVLALDNDQLRHSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGA 91
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443   92 VTHNIWGIILARLLQG--AGAVSSVLLATAGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGLTGVFLVAAAL 169
Cdd:pfam07690  81 FASSLWLLLVLRVLQGlgAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  170 GVLALLPLWKVIPP----IPRNLQQRMGNWRDALRIFRYPPVLTASVGIFILQMVLGAsFVVLSPELVKAMHIPGSAVWE 245
Cdd:pfam07690 161 SLLAAVLLLLPRPPpeskRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFG-LLTYLPLYQEVLGLSALLAGL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  246 VYLPVMLLSVAGMLYPVIHAERHRQHGQMLVFSGLAIAAGALFMGLLAGHFWPVAVGAVIFF-TGYNVASAILPSMMSRS 324
Cdd:pfam07690 240 LLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLgFGFGLVFPALNALVSDL 319

                         330       340
                  ....*....|....*....|...
gi 198247443  325 TTQEQRGAASGVYSLMQFLGIFA 347
Cdd:pfam07690 320 APKEERGTASGLYNTAGSLGGAL 342
2_A_01_02 TIGR00880
Multidrug resistance protein;
46-183 1.29e-13

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 67.67  E-value: 1.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443   46 GLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQG--AGAVSSVLLATAGDLT 123
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGfgAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  124 GEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGLTGVFLVAAALGVLALLPLWKVIPP 183
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPE 140
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
44-112 5.16e-07

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 51.43  E-value: 5.16e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 198247443  44 LLGLAIGiyglaqaalQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQGAGAVS 112
Cdd:PRK11043  51 LAGFALG---------QLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVGVCS 110
 
Name Accession Description Interval E-value
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 12-347 3.77e-89

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 274.09  E-value: 3.77e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  12 LSFIYVARMLGLFMLMPVLALDNDQLRHSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGA 91
Cdd:cd17472    1 LSLIFSLRMLGMFLVLPVLSVYAKSLPGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  92 VTHNIWGIILARLLQGAGAVSSVLLATAGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGLTGVFLVAAALGV 171
Cdd:cd17472   81 YATSIYGLILGRALQGSGAISSVVMALLADLTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 172 LALLPLWKVIPPIPRNLQQRMGNWRDALRIFRYPPVLTASVGIFILQMVLGASFVVLsPELVKAMHIPGSAVWEVYLPVM 251
Cdd:cd17472  161 VSLLILLFFVPDPPKIVQISEKEKKKLKKLLKNKRLLRLDFSIFILHFVLMAFFYIL-PLLLTQLGGGKGQLWKVYLPAI 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 252 LLSVAGMLYPVIHAERHRQHGQMLVFSGLAIAAGALFMGLLAGHFWPVAVGAVIFFTGYNVASAILPSMMSRSTTQEQRG 331
Cdd:cd17472  240 LIGFILMVPFVIYAEKKGKMKQVFVSSILLIAVGFLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRG 319

                        330
                 ....*....|....*.
gi 198247443 332 AASGVYSLMQFLGIFA 347
Cdd:cd17472  320 TAMGIYNTSQFLGSFL 335
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
2-345 5.67e-36

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 134.72  E-value: 5.67e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443   2 SPFEKRAVAGLSFIYVARMLGLFMLMPVLALDNDQLrHSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLL 81
Cdd:COG2814    5 PRRRWLALLALALGAFLSGLGIGIVLPALPLIAADL-GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  82 IFVLGSLLGAVTHNIWGIILARLLQG--AGAVSSVLLATAGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGL 159
Cdd:COG2814   84 LFALGSLLCALAPSLWLLLAARFLQGlgAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGW 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 160 TGVFLVAAALGVLALLPLWKVIPPIPRNLQQRMGnwRDALRIFRYPPVLTASVGIFILQMVLGASFVVLSPELVKAMHIP 239
Cdd:COG2814  164 RWVFLVNAVLALLALLLLLRLLPESRPAARARLR--GSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLS 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 240 GSAVWEVYLPVMLLSVAGMLYPVIHAERHrqHGQMLVFSGLAIAAGALFMGLLAGHFWPVAVGAVIFFTGYNVASAILPS 319
Cdd:COG2814  242 ASAAGLLLALFGLGGVLGALLAGRLADRF--GRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQA 319

                        330       340
                 ....*....|....*....|....*.
gi 198247443 320 MMSRSTTQEQRGAASGVYSLMQFLGI 345
Cdd:COG2814  320 LVAELAPPEARGRASGLYNSAFFLGG 345
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 12-346 2.70e-34

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 130.77  E-value: 2.70e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  12 LSFIYVARMLGLFMLMPVLALDNDQLrHSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGA 91
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAESL-GASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  92 VTHNIWGIILARLLQGAGA--VSSVLLATAGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGLTGVFLVAAAL 169
Cdd:cd17325   80 FATSYWQLLLARFLQGLASaaVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 170 GVLALLPLWKVIP----PIPRNLQQRMGNWRDALRIFRYPPVLTASVGIFILQMVLGASFVVLSPELVKAMHIPGSAVWE 245
Cdd:cd17325  160 ALLALVLALLLLPeprpPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 246 VYLPVMLLSVAGMLYPVIHAERHRQHgqMLVFSGLAIAAGALFMGLLAGHFWPVAVGAVIFFTGYNVASAILPSMMSRST 325
Cdd:cd17325  240 LFGAQGLASALSQPPAGKLSDRIGRK--PLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIV 317

                        330       340
                 ....*....|....*....|.
gi 198247443 326 TQEQRGAASGVYSLMQFLGIF 346
Cdd:cd17325  318 PPEGRGTAMGLFNTAFSLGMV 338
MFS_1 pfam07690
Major Facilitator Superfamily;
12-347 3.14e-27

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 110.59  E-value: 3.14e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443   12 LSFIYVARMLGLFMLMPVLALDNDQLRHSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGA 91
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443   92 VTHNIWGIILARLLQG--AGAVSSVLLATAGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGLTGVFLVAAAL 169
Cdd:pfam07690  81 FASSLWLLLVLRVLQGlgAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  170 GVLALLPLWKVIPP----IPRNLQQRMGNWRDALRIFRYPPVLTASVGIFILQMVLGAsFVVLSPELVKAMHIPGSAVWE 245
Cdd:pfam07690 161 SLLAAVLLLLPRPPpeskRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFG-LLTYLPLYQEVLGLSALLAGL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  246 VYLPVMLLSVAGMLYPVIHAERHRQHGQMLVFSGLAIAAGALFMGLLAGHFWPVAVGAVIFF-TGYNVASAILPSMMSRS 324
Cdd:pfam07690 240 LLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLgFGFGLVFPALNALVSDL 319

                         330       340
                  ....*....|....*....|...
gi 198247443  325 TTQEQRGAASGVYSLMQFLGIFA 347
Cdd:pfam07690 320 APKEERGTASGLYNTAGSLGGAL 342
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 23-345 3.21e-25

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 105.32  E-value: 3.21e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  23 LFMLMPVLALDNDQLrHSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILA 102
Cdd:cd17324   15 EYVIQGLLPDIARDF-GVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLA 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 103 RLLQG--AGAVSSVLLATAGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGLTGVFLVAAALGVLALLPLWKV 180
Cdd:cd17324   94 RALAGlaHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRL 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 181 IPPIPRNLQQRMGNWRDALRIFRYPPVLTASVGIFILQMVLGASFVVLSPELVKAMHIPGSAVWEVYLPVMLLSVAGMLY 260
Cdd:cd17324  174 LPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPL 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 261 PVIHAERHrqHGQMLVFSGLAIAAGALFMGLLAGHFWPVAVGAVIFFTGYNVASAILPSMMSRSTTqEQRGAASGVYSLM 340
Cdd:cd17324  254 AGRLADRG--GRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAP-EARGLASSLYLAA 330


                 ....*
gi 198247443 341 QFLGI 345
Cdd:cd17324  331 YNLGG 335
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 9-344 8.72e-25

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 104.19  E-value: 8.72e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443   9 VAGLSFIYVARMLGLFMLMPVLALDNDQLrHSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSL 88
Cdd:cd17474    1 LYAVFFATLLAVLGVSIVDPILPAIAEAL-GASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  89 LGAVTHNIWGIILARLLQGAGAVSSVLLATA--GDLTGEQHRTKAMaaigGSIAIAYVLGMAMGPVFYGLSGLTG----V 162
Cdd:cd17474   80 LCGLSDSFALLLAGRALQGIGAAGLGPLALTliGDLFEGGERAKAM----GLYEAALGLGIAVGPLLGGLLAAISwrypF 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 163 FLVAAALGVLALLPLWKVIPPIPRNLQQRMGNWRDALRIFRYPPVLTASVGIFILQMVLGASFVVLSPELVKAMHIPGSA 242
Cdd:cd17474  156 FLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPII 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 243 VWEVYLPvMLLSVAGMLYPVIHAERHRQHGQMLVFSGLAIAAGALFMGLLAGHFWPVAVGAVIFFTGYNVASAILPSMMS 322
Cdd:cd17474  236 IGLLFAG-WSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVT 314

                        330       340
                 ....*....|....*....|..
gi 198247443 323 RSTTQEQRGAASGVYSLMQFLG 344
Cdd:cd17474  315 ELAPEEERGTASSLYNFVRFLG 336
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 20-365 3.49e-23

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 99.59  E-value: 3.49e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  20 MLGLFMLMPVLALDNDQLrHSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGI 99
Cdd:cd17489    9 FLSFYLLLPVLPLYAHDL-GGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 100 ILARLLQGAG--AVSSVLLATAGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGLTGVFLVAAALGVLALLPL 177
Cdd:cd17489   88 LVLRLIHGIGwgAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLV 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 178 WKVIPPIPRNLQQRMGNwRDALRIFRYPPVLTASVGIFILQMVLGA--SFVVLspelvKAMHIPGSAVW---EVYLPVML 252
Cdd:cd17489  168 FLVKDPPPVAAEEAEAG-TRAFRRLVEKKVLPPALILFLASIAYGAisTFLPL-----YAAERGISNAGlffTVYAIALL 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 253 LS--VAGMLYPvihaerhRQHGQMLVFSGLAIAAGALFMGLLAGHFWPVAVGAVIFFTGYNVASAILPSMMSRSTTQEQR 330
Cdd:cd17489  242 LSrpFSGKLSD-------RKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRR 314

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 198247443 331 GAASGVYSLMQFLGIFAGGVVGGWGLGMAGEQGVF 365
Cdd:cd17489  315 GAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMF 349
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 12-344 2.55e-22

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 97.50  E-value: 2.55e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  12 LSFIYVARMLGLFMLMPVLALDNDQLrHSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGA 91
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSF-GLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  92 VTHNIWGIILARLLQGAGA--VSSVLLATAGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVF--YGLSGLTGVFLVAA 167
Cdd:cd06174   80 FAPSFWLLLLGRFLLGLGSglIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILasSLGFGWRAVFLIAA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 168 ALGVLALLPLWKVIPPIPRNLQQRMG------NWRDALRIFRYPPVLTASVGIFILQMVLGASFVVLSPELVKAMHIPGS 241
Cdd:cd06174  160 ALALLAAILLLLVVPDPPESARAKNEeassksVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVA 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 242 AVWEVYLPVMLLSVAGMLYPVIHAERHRQHGQMLVFSGLAIAAGALFMGLLAGHFWPVAVGAVIFFTGYNVASAILpSMM 321
Cdd:cd06174  240 VAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSF-ALI 318

                        330       340
                 ....*....|....*....|...
gi 198247443 322 SRSTTQEQRGAASGVYSLMQFLG 344
Cdd:cd06174  319 AELFPPEIRGTAFGLLNTFGFLG 341
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 39-347 8.37e-19

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 87.25  E-value: 8.37e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  39 HSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQ--GAGAVSSVLL 116
Cdd:cd17320   30 GASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQglGAAAGSVVAR 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 117 ATAGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGLTGVFLVAAALGVLALLPLWKVIP---PIPRNLQQRMG 193
Cdd:cd17320  110 AIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPetlPEEKRKPLLSS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 194 NWRDALRIFRYPPVLtASVGIFILQMVLGASFVVLSPEL-VKAMHIPGSAV-WEVYLPVMLLSVAGMLYPVIhAERHRQH 271
Cdd:cd17320  190 LLRAYKRVLKNRRFL-GYALALGLSFAGLFAYLAAAPFIyIEQLGLSPAQFgLLFALNAIALILGSLLNGRL-VRRFGPR 267

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 198247443 272 GQMLVFSGLAIAAGALFMG---LLAGHFWPVAVGAVIFFTGYNVASAILPSMMSRSTTQeQRGAASGVYSLMQFLGIFA 347
Cdd:cd17320  268 RLLRLGLLLLLAAALVLLLaalLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPH-VAGTASALLGFLQFLIGAL 345
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 39-344 1.03e-18

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 86.84  E-value: 1.03e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  39 HSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQGAGA--VSSVLL 116
Cdd:cd17321   27 GASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAaaIMPASL 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 117 ATAGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGLTGVFLVAAALGVLALLPLwkvippiprnlqqrmgnwr 196
Cdd:cd17321  107 ALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLA------------------- 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 197 dalrifryPPVLTASVGIFILQMVLGASFVVLSPELVKAMHIP----GSAVWEVYLPVMLLS-VAGMLYPVIHAerhrqh 271
Cdd:cd17321  168 --------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSplqaGLALLPLALAMLVAApLAGRLADRFGP------ 233

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 198247443 272 GQMLVFSGLAIAAGALFMGLLAGH--FWPVAVGAVIFFTGYNVASAILPSMMSRSTTQEQRGAASGVYSLMQFLG 344
Cdd:cd17321  234 RLVLVAGLLLTAVGLLLLALLGADssVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLG 308
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 12-344 8.44e-18

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 84.17  E-value: 8.44e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  12 LSFIYVARMLGLFMLMPVLALDNDQLrHSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGA 91
Cdd:cd17504    1 LALAALAVMLVETMLSPALPTIQREF-GTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  92 VTHNIWGIILARLLQGAG-AVSSVLLATAGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGLTGVFLVAAALG 170
Cdd:cd17504   80 FAPNLPVLIAGRALQGIGgAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 171 VLALLplwkVIPPIPrnlqqrmgnwrdaLRIFRYPPVLTASVGIFILQMVLGASFVVLsPELVK--AMHIPGSAVWEVYL 248
Cdd:cd17504  160 VLLAA----LVPLID-------------LRLLRRRNVLLANITALLAGFGMFMVFQLL-PQLLQlpTPTGFGLGITEAGL 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 249 PVMLLSVAGMLYPVIHAERHRQHG--QMLVFSGLAIAAGALFMGLLAGHFWPVAVGAVIFFTGYNVASAILPSMMSRSTT 326
Cdd:cd17504  222 LLLPGALVMLIAGPLAGRLIARVGprRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVP 301

                        330
                 ....*....|....*...
gi 198247443 327 QEQRGAASGVYSLMQFLG 344
Cdd:cd17504  302 PDRTGIATGMNTVLRTIG 319
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
41-366 1.04e-17

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 83.77  E-value: 1.04e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  41 TPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQGAG--AVSSVLLAT 118
Cdd:COG2271   43 SAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGeaGFFPAALKL 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 119 AGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGLTGVFLVAAALGVLALLplwkvippiprnlqqrmgnwrda 198
Cdd:COG2271  123 IAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLAL----------------------- 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 199 lrifryPPVLTASVGIFILQMVLGASFVVLSPELVKAMHIPGSAVWEVYLPVMLLSVAGMLYPVIHAERHRQHGQMLVFS 278
Cdd:COG2271  180 ------LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAI 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 279 GLAIAAGALFMGLLAGHFWPVAVGAVIFFTGYNVASAILPSMMSRSTTQEQRGAASGVYSLMQFLGIFAGGVVGGWGLGM 358
Cdd:COG2271  254 GLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDA 333


                 ....*...
gi 198247443 359 AGEQGVFY 366
Cdd:COG2271  334 TGYQAAFL 341
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
6-347 1.04e-17

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 84.16  E-value: 1.04e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443   6 KRAVAGLSFIYVARMLGLFMLMPVLALDNDQLRHSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVL 85
Cdd:COG2223    3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  86 GSLLGAVTHNIWGIILARLLQG--AGAVSSVLLATAGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGLTGVF 163
Cdd:COG2223   83 GLLLLALAVSYWLLLLLGLLLGigGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 164 LVAAALGVLALLPLWKVIPPIPRNLQQ-RMGNWRDALRIFRYPPVLTASVGIFILQMVLGASFVVLSPELVKAMHIP--- 239
Cdd:COG2223  163 LILGILLLVVAVLAWLFLRDPPAGAAAaAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSaat 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 240 -GSAVWEVYLPVMLLS-VAGMLYPVIHAERhrqhgqMLVFSGLAIAAGALFMGLLAGHFWPVAVGAVIFFTGYNVASAIL 317
Cdd:COG2223  243 aGLLAALFALLGALGRpLGGWLSDRIGGRR------VLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAV 316

                        330       340       350
                 ....*....|....*....|....*....|
gi 198247443 318 PSMMSRSTTQEQRGAASGVYSLMQFLGIFA 347
Cdd:COG2223  317 FALVPDIFPTKNAGAVYGLVGAAGGLGGFL 346
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 21-344 2.59e-17

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 82.66  E-value: 2.59e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  21 LGLFMLMPVLALDNDQLRHSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGII 100
Cdd:cd17329   13 LGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 101 LARLLQGAGA--VSSVLLATAGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGLTGVFLVAAALGVLALLPLW 178
Cdd:cd17329   93 IALVLTGFGGglFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLLF 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 179 KVIPPIPRNLQQRMGNWRDALRI-FRYPPVLTASVGIFILQMVLGASFVVLSPELVKAMHIPGSAVWEVYLPVMLLSVAG 257
Cdd:cd17329  173 LLPETRPKRRAAEKTEILRGYKIvLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLL 252

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 258 MlYPVIHAERHRQHGQMLVFsGLAIAAGALFMGLLAGHFWPVAVGAVIFFTGYNVASAILPSMMSRSTTQEQRGAASGVY 337
Cdd:cd17329  253 Q-FPVARLVERFRLRKILMI-GILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFY 330


                 ....*..
gi 198247443 338 SLMQFLG 344
Cdd:cd17329  331 ALAWGLG 337
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 20-347 9.49e-17

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 81.08  E-value: 9.49e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  20 MLGLFMLMPVLALDNDQLRHSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGI 99
Cdd:cd17473   12 VMAGAAIAPALPAIAQHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYAL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 100 ILARLLQGAG--AVSSVLLATAGDLTGEQHRTKAMAAIGGSIAIAyvlgmamGPVFYGLSGLTGVFL-----VAAALGVL 172
Cdd:cd17473   92 LASRALLGIGvaGIMTLATALIGDYFEGEERAKMLGLQSAAMSLG-------GVVFLLLGGALAEIGwrapfLVYLLALP 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 173 ALLPLWKVIPPIPRNLQQRMGNWRDALRIFRYPPVLTASVGIFiLQMVLGASFVVLSPELVKAMHIPGSAVWEVYLPVML 252
Cdd:cd17473  165 VLILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAF-LAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIAS 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 253 L--SVAGMLYPVIHAERHRqhgQMLVFSGLAIAAGALFMGLLAGHFWPVAVGAVIFFTGYNVASAILPSMMSRSTTQEQR 330
Cdd:cd17473  244 LagAIGALLFGRLKRRLGK---RRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELR 320

                        330
                 ....*....|....*..
gi 198247443 331 GAASGVYSLMQFLGIFA 347
Cdd:cd17473  321 GRAMGIVTSAFFLGQFL 337
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 21-344 1.11e-16

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 80.70  E-value: 1.11e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  21 LGLFMLMPVLA--LDNDQLRHSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWG 98
Cdd:cd17330   10 LGFGIVFPVLPfyVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  99 IILARLLQGA-GAVSSVLLATAGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGLTGVFLVAAALGVLALLPL 177
Cdd:cd17330   90 LFLARFLDGLtGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLV 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 178 WKVIPPIPRnlqqrmgnwrdalrifryppVLTASVGIFILQMVLGASFVVLSPELVKamhipgsavWEVYLPVMLLSVAG 257
Cdd:cd17330  170 LFFLPPLRR--------------------LLLVYFLIALAFAGLESVFSLFLKDRFG---------FSPSQIGLLLALVG 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 258 M--------LYPVIHA---ERHrqhgqmLVFSGLAIAAGALFMGLLAGHFWPVAVGAVIFFTGYNVASAILPSMMSRSTT 326
Cdd:cd17330  221 IagilaqllLIPRLAKrlgERK------LLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVP 294

                        330
                 ....*....|....*...
gi 198247443 327 QEQRGAASGVYSLMQFLG 344
Cdd:cd17330  295 SKEQGKAQGIIQSLQSLA 312
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 6-265 2.13e-14

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 73.31  E-value: 2.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443   6 KRAVAGLSFIYVARMLGLFMLMPVLALDNDQLrHSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVL 85
Cdd:COG0477   13 RRALLALALGTFLEGLDFTIVNVALPSIAADL-GASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  86 GSLLGAVTHNIWGIILARLLQG--AGAVSSVLLATAGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGLTGVF 163
Cdd:COG0477   92 ASLLCGLAPSPELLIAARALQGigAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 164 LVAAALGVLALLPLWKVIPPIPRNLQQRMGNWRDALRIFRYPPVLTASVGIFILQMVLGASFVVLSPELVKAMHIPGSAV 243
Cdd:COG0477  172 LINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALL 251

                        250       260
                 ....*....|....*....|..
gi 198247443 244 WEVYLPVMLLSVAGMLYPVIHA 265
Cdd:COG0477  252 LLLALLLLAALLLLLLLLLLLA 273
2_A_01_02 TIGR00880
Multidrug resistance protein;
46-183 1.29e-13

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 67.67  E-value: 1.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443   46 GLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQG--AGAVSSVLLATAGDLT 123
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGfgAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  124 GEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGLTGVFLVAAALGVLALLPLWKVIPP 183
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPE 140
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 44-346 3.94e-13

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 69.94  E-value: 3.94e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  44 LLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVF-GLLIFVLGSLLGAVTHNIWGIILARLLQGAGA----VSSVLLAT 118
Cdd:cd17490   32 MIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIiGLLFTVLASLIMILFPSPWGLLIARFLSGIAAatwvSFTVLYAS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 119 agdLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGLTGVFLVAAALGVLALLPLWKVIPPiPRNLQQRMGNWRDA 198
Cdd:cd17490  112 ---YFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEE-RREKKPVLTELKEL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 199 LRIFRYPPVLTASVGIFILQMVLGASFVVLSPELVKAMHIPGSAVWEVYLPVMLLSVAGMLYPVIHAERhRQHGQMLVFS 278
Cdd:cd17490  188 LSVLKDKKLLFFSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLSIIYLLPNALASLLSGTLFYK-KLGERNTIII 266

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 198247443 279 GLAIAAGALFMGLLAGHFWPVAVGAVIFFTGYNVASAILPSMMSRSTTQEQRGAASGVYSLMQFLGIF 346
Cdd:cd17490  267 GFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMF 334
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 44-153 5.01e-13

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 69.51  E-value: 5.01e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  44 LLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQ--GAGAVSSVLLATAGD 121
Cdd:cd17502   31 LVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQgiGGGGLMSLAFIIIAD 110

                         90       100       110
                 ....*....|....*....|....*....|..
gi 198247443 122 LTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVF 153
Cdd:cd17502  111 LVPPRERGKYQGYIGAVFGIASVAGPLIGGAF 142
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 6-168 5.75e-13

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 69.53  E-value: 5.75e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443   6 KRAVAGLSFIYVARMLGLFMLMPVLALDNDQLRHSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVL 85
Cdd:cd17325  198 DRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAV 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  86 GSLLGAVTHNIWGIILARLLQGAG--AVSSVLLATAGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGLTGVF 163
Cdd:cd17325  278 ALLLLPLATSFWLLLLLLALLGLGlgLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPF 357


                 ....*
gi 198247443 164 LVAAA 168
Cdd:cd17325  358 LAAAA 362
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 21-347 3.10e-11

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 64.19  E-value: 3.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  21 LGLFMLMPVL-ALDNDQLRHSTPVllGLAIGIYGLAQAALQFPF----GVASDRFGRKRVLVFGLLIFVLGSLLGAVTHN 95
Cdd:cd17388   13 MGIGLIMPVLpTLLREFVGDSADA--ATHYGVLLALYALMQFIFapilGALSDRFGRRPVLLLSLAGAALDYLLMAFAPT 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  96 IWGIILARLLQG-AGAVSSVLLATAGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSgLTGVFLVAAALGVLAL 174
Cdd:cd17388   91 LWWLYLGRIIAGiTGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEIS-PRAPFLVAAGLNGLNF 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 175 LPLWKVIPPIPRNLQQRMGNWRDALRI------FRYPPVLTASVGIFILQMVLgasfvvlspelvkamHIPGSaVWEVYL 248
Cdd:cd17388  170 LLGLFVLPESLPPERRRAFRWRRANPFgslrwlTGFPGLLGLLAVFFLIQLIG---------------QVPAT-TWVLFT 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 249 -------PVML---LSVAGMLYPVIHAERHRQHGQML-----VFSGLAIAAGALFMGLLAGHFWpVAVGAVIFFTGYNVA 313
Cdd:cd17388  234 edrfdwsPTMVglsLAVFGLLHALFQAFVTGPIAKRLgekraILLGLAADALGFLLLAFATQGW-MVFPILILLALGGIA 312

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 198247443 314 SAILPSMMSRSTTQEQRGAASGVY-SLMQFLGIFA 347
Cdd:cd17388  313 GPALQGLLSRQVPENEQGELQGVLtSLTSLTSIIG 347
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 42-372 6.65e-11

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 63.40  E-value: 6.65e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  42 PVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVF-----GLLIFVLGSLLGAVTHNIWGIILARLLQGAGAV--SSV 114
Cdd:cd06173   33 ALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadllrALLAAVLALLALLGSLSLWLLLVLAFLLGIASAffGPA 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 115 LLATAGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGLTGVFLVAAALGVLALLPLWKVIPPIPRNLQQR--- 191
Cdd:cd06173  113 RQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESssl 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 192 -MGNWRDALRIFRYPPVLTASVGIFILQMVLGASFVVLSPELVKamHIPGSAVWEVYLPVMLLSVAGMLYPVIHAERHRQ 270
Cdd:cd06173  193 lLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAK--EVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKR 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 271 HGQMLVFSGLAIAAGALFMGL-LAGHFWPVAVGAVIFFTGYNVASAILPSMMSRSTTQEQRGAASGVYSLMQFLGIFAGG 349
Cdd:cd06173  271 RRRGRLLLIGALLLGLALLVLgLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGA 350

                        330       340
                 ....*....|....*....|...
gi 198247443 350 VVGGWGLGMAGEQGVFYLLAVVG 372
Cdd:cd06173  351 LLAGLLADALGLSAVFLLAGALL 373
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 39-344 1.62e-10

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 62.21  E-value: 1.62e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  39 HSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQGA--GAVSSVLL 116
Cdd:cd17503   27 GASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFggGVLIPLAQ 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 117 ATAGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGLTGVFLVAAALGVLALlplwkVIPPIPRnlqqrmgnwr 196
Cdd:cd17503  107 TILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILAL-----LLAPLLD---------- 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 197 daLRIFRYPPVLTASVGIFILQMVLGASFVVLSPELVKAMHIPGSAVWEVYLPVMLLSVAGMlyPVIHAERHRQHGQMLV 276
Cdd:cd17503  172 --LRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILS--PLVGRLLDKFGPRLLL 247

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 198247443 277 FSGLAIAAGALFMGLLAGH---FWPVAVGAVIFFTGYNVASAILPSMMSRSTTQEQRGAASGVYSLMQFLG 344
Cdd:cd17503  248 LAGLLLLALGTLLLAFLTPdtsLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLG 318
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 39-153 2.14e-10

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 61.82  E-value: 2.14e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  39 HSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQGAGAvSSVLLAT 118
Cdd:cd17323   30 HVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFG-SSPLAIG 108

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 198247443 119 AG---DLTGEQHRTKAMAaiggsiaiAYVLGMAMGPVF 153
Cdd:cd17323  109 AGtiaDLFTPEERGKAMG--------VYSLGPLLGPAL 138
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 40-157 6.46e-10

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 60.30  E-value: 6.46e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  40 STPVLLGLAIGIYGLAQAALQFPFGVASDRFG-RKRVLVFGLLIFVLGSLLGAV-----THNIWGIILARLLQGAGAVS- 112
Cdd:cd17326   33 ATASFFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVGNILYALaeyfpSNRKYVMLVARFLIGVGAGNv 112

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 198247443 113 SVLLATAGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLS 157
Cdd:cd17326  113 AVLRAYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTPIG 157
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
42-344 5.40e-09

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 57.60  E-value: 5.40e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  42 PVLLGLAIGIYGLAQAALQFPFGVASD----RFGRKR-VLVFGLLIFVLGSLL------GAVTHNIWGIILARLLQGAG- 109
Cdd:COG2211   45 AALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRpWILIGAIPLALSFVLlftapdLSPTGKLIYALVTYLLLGLAy 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 110 -AVSSVLLATAGDLTGEQH-RTKAMAAIGGSIAIAYVLGMAMGPVFYGL------SGLTGVFLVAAALGVLALLPLWKVI 181
Cdd:COG2211  125 tLVNIPYSALGAELTPDYEeRTRLSSWRFAFAGLGGLLASVLPPPLVAAfggdaaLGYRLTALIFAVLGLLAFLLTFFGT 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 182 PPIPRNLQQRMGNWRDALRIFRYPPVLTASVGIFILQMVLGASFVVLSPELVKAMHIPGSAVWEVYLPVMLLSVAGMLYP 261
Cdd:COG2211  205 KERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLW 284

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 262 VIHAERHRQHGQMLVFSGLAIAAGALFMGLLAGHFWPVAVGAVIFFTGYNVASAILPSMMSRS-------TTQEQRGAAS 334
Cdd:COG2211  285 PRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVvdydewkTGRRREGLYF 364

                        330
                 ....*....|
gi 198247443 335 GVYSLMQFLG 344
Cdd:COG2211  365 GIFTFAIKLG 374
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 43-153 6.23e-09

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 57.28  E-value: 6.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  43 VLLGLAIG-IYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQGAgAVSSVLLATA-- 119
Cdd:cd17389   63 VLFGGLIGsLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGI-SKGNVSLSTAiv 141

                         90       100       110
                 ....*....|....*....|....*....|....
gi 198247443 120 GDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVF 153
Cdd:cd17389  142 ADVTSPKKRSKGMALIGVAFSLGFIIGPMIGAYF 175
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 36-163 7.52e-09

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 56.78  E-value: 7.52e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  36 QLRHSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQGA--GAVSS 113
Cdd:cd17370  227 QELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLymGAQES 306

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 198247443 114 VLLATAGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGLTGVF 163
Cdd:cd17370  307 IERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAF 356
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 41-347 9.14e-09

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 56.42  E-value: 9.14e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  41 TPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQG---AGAVSSVLLA 117
Cdd:cd17319   36 SPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGvaeAGFFPGAIKA 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 118 TAgDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGLTGVFLVAAALGVLALLPLWkvippiprnlqqrmgnwrd 197
Cdd:cd17319  116 LA-EWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWW------------------- 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 198 alriFRYPPVLTASVGIFILQMVLGASFVVLSPELVKAMHIPGSAV-WEVYLPvMLLSVAGMLYPVIHAERHRQHGQ-ML 275
Cdd:cd17319  176 ----FYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVgLLAAIP-FLAGAIGMILGGRLSDRLLRGARrLV 250

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 198247443 276 VFSGLAIAAGALFMGLLAGHFWPVAVGAVIFFTGYNVASAILPSMMSRSTTQEQRGAASGVYSLMQFLGIFA 347
Cdd:cd17319  251 IIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFV 322
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 10-153 1.49e-08

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 56.48  E-value: 1.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  10 AGLSFIYVARMLGLFMLMPVLALDNDQLRHSTpvLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLL 89
Cdd:cd06179    1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPSS--NSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIV 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 198247443  90 GAVTHNIWGIILARLLQGAGAVSSVLL-ATAGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVF 153
Cdd:cd06179   79 AGTAKSVNMLIGGQALIGIGAGTQGLGaAVASELVPNKYRGLVQGVVNLVASPGSALGPLIAGAL 143
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
8-344 1.48e-07

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 52.95  E-value: 1.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443   8 AVAGLSFIYVARMLGLFMLMPVLALDNDQLrHSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGS 87
Cdd:COG2807   19 LLLAIVLVALNLRPAITSVGPLLPEIRADL-GLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  88 LLGAVTHNIWGIILARLLQGAG-AVSSVLLATAGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGLTGVFLVA 166
Cdd:COG2807   98 LLRSLAPSVALLLAGTALIGAGiAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVW 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 167 AALGVLALLPLWKVIPPIPRNLQQRMGNWRdALRIFRYPPVLTASVgIFILQMVLGASFVVLSPELVKAMHIPGSAVWEV 246
Cdd:COG2807  178 ALLALLALLLWLPLLRRRPAAAAAAPAAAS-LRSLWRSPLAWLLTL-FFGLQSLLYYAVVAWLPPILRDAGLSAATAGLL 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 247 YLPVMLLSVAGMLYPVIHAERHRQHGQMLVFSGLAIAAGalFMGLLAGHFWPVAVGAVIFFTGYNVASAILPSMMS-RST 325
Cdd:COG2807  256 LSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAG--LLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGlRAR 333

                        330
                 ....*....|....*....
gi 198247443 326 TQEQRGAASGvysLMQFLG 344
Cdd:COG2807  334 TPAEAAALSG---MAQSVG 349
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 39-347 1.60e-07

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 52.60  E-value: 1.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  39 HSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQGA--GAVSSVLL 116
Cdd:cd17316   32 GLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIgiGGEYPGAS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 117 ATAGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGLTgvflvaaalgvlallPLWKV------IPPIprnlqq 190
Cdd:cd17316  112 TYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGD---------------WGWRIlfligaLPAL------ 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 191 rmgnwrdaLRIFRYPPVLTASVGIFILQMVLGASFVVLSPELVKAMHIPGSAVWEVYLPVMLLSVAGMLYPVIHAERHRQ 270
Cdd:cd17316  171 --------LALLLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGR 242

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 198247443 271 HGQMLVFSGLAIAAGALFMGLLAGHFWPVAVGAVIFFTGYNVASAILPSMMSRSTTQEQRGAASGV-YSLMQFLGIFA 347
Cdd:cd17316  243 KKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLsYNLGRLGGGGA 320
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 45-347 3.95e-07

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 51.47  E-value: 3.95e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  45 LGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQGAGAvSSVLLATAGDLTG 124
Cdd:cd17475   33 VGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGY-GSVQPGGGRAIMR 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 125 ---EQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGLTGVFLVAAALGVLALLPLWKVI--PPIPRNLQQR-MGNWRDA 198
Cdd:cd17475  112 wfpPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYrePPAASAATESaSTLLRSL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 199 LRIFRYPPVLTASVGIFILQMVLGASFVVLSPELVKAMHIPGSAVWEVYLPVMLLSVAGMLYPVIHAERHRQHGQMLVFS 278
Cdd:cd17475  192 KEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGRRRPVLV 271

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 198247443 279 GLAIAAGALF--MGLLAGHFWPVAVGAVIFFTGYNVAS--AILPSMMSRSTTQEQRGAASGVYSLMQFLGIFA 347
Cdd:cd17475  272 ITAAIAAAALlvLSLLSPGTPLWLLVLLLILLGLFAIGwnGLYLTLVAESAGPEQAGTALGLANTINFIGIAI 344
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
44-112 5.16e-07

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 51.43  E-value: 5.16e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 198247443  44 LLGLAIGiyglaqaalQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQGAGAVS 112
Cdd:PRK11043  51 LAGFALG---------QLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVGVCS 110
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 20-366 6.77e-07

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 50.63  E-value: 6.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  20 MLGLFMLMPVLALDNDQLRHSTpVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGI 99
Cdd:cd17477    9 GLGSGLLLPLLSLRLEREGVST-ALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVW 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 100 ILARLLQGAG-AVSSVLLATA-GDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGLT-GVFLVAAALGVLALLP 176
Cdd:cd17477   88 FLLRFVMGIGlAGLFVVSESWlNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPfLIAAVLLLLALVPLLL 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 177 LWKVIPPIPRNlqqrmgNWRDALRIFRYPPVLTasVGIFILQMVLGASFVVLSPELVKAMHIPGSAVWevYLPVMLLSVA 256
Cdd:cd17477  168 TRRAAPEIEEA------ESISLRRLLRIAPLAL--LGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAAL--LLAAFVLGGL 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 257 GMLYPVIHAERHRQHGQMLVFSGLAIAAGALFMGLLAGHFWPVAVGAVIF----FTGYNVASAILPSmmsrSTTQEQRGA 332
Cdd:cd17477  238 LLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWggaaGPLYTLALALAGD----RLPGDELVA 313

                        330       340       350
                 ....*....|....*....|....*....|....
gi 198247443 333 ASGVYSLMQFLGIFAGGVVGGWGLGMAGEQGVFY 366
Cdd:cd17477  314 ANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFL 347
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 13-150 7.01e-07

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 50.85  E-value: 7.01e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443   13 SFIYVARMLGLFMLMP---------VLALDNDQLRHSTPVLLGLAIGIYGLAQAalQFPFGVASDRFGRKRVLVFGLLIF 83
Cdd:TIGR00710   3 AKAFALLLGCLSILGPlgidmylpaFPEIAADLSTPASIVQMTLTLYLLGFAAG--QLLWGPLSDRYGRRPVLLLGLFIF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 198247443   84 VLGSLLGAVTHNIWGIILARLLQGAGAVSSVLL--ATAGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMG 150
Cdd:TIGR00710  81 ALSSLGLALSNNIETLLVLRFVQAFGASAGSVIsqALVRDIYPGEELSRIYSILMPVLALAPAVAPLLG 149
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
45-150 7.27e-07

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 50.79  E-value: 7.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  45 LGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQGAGAVSSVLLATA--GDL 122
Cdd:PRK10473  40 LHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAilRDT 119

                         90       100
                 ....*....|....*....|....*...
gi 198247443 123 TGEQHRTKAMAAIGGSIAIAYVLGMAMG 150
Cdd:PRK10473 120 LDDRRRAKVLSLLNGITCIIPVLAPVLG 147
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 41-346 9.63e-07

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 50.23  E-value: 9.63e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  41 TPVLLGLAIGIYGLAQAALQFPFGVASDRFG-RKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQGAG-----AVSSV 114
Cdd:cd17370   32 SAAAVGLIEGLAEALGSLLRLFSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVLLLRILERLGkgirtPPRDA 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 115 LLAtagDLTGEQHRTK------AMAAIGGSIAIAYVLGMamgpVFYGLSGLTGVFLVAAALGVLALLPLWKVIPPIPRNL 188
Cdd:cd17370  112 LLA---DATPPSGRGKafglhrALDTLGAVLGPLLAALL----LYLLGGNYRTIFLLAAIPALLALLILLFVVKEYPRPP 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 189 QQRMGNWRDALRIFRYP-PVLTASVGIFilqmVLGASFVVLSPELVKAMHIPGSAVWEVYLPVMLLS-----VAGMLYPV 262
Cdd:cd17370  185 KLRKKSKKTSLKKLPKAfWLYLLAVALF----ALGNFSFAFLILRAQELGLSAALIPLLYALFNLVYalaayPAGRLSDR 260

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 263 IHAERhrqhgqmLVFSGLAIAAGALFMGLLAGHFWPVAVGAVIFFTGYNVASAILPSMMSRSTTQEQRGAASGVYSLMQF 342
Cdd:cd17370  261 IGRKK-------LLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVG 333


                 ....
gi 198247443 343 LGIF 346
Cdd:cd17370  334 IGWL 337
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
12-156 9.99e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 50.67  E-value: 9.99e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  12 LSFIYVARMLGLFMLMPVLALDNDQLRHSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGA 91
Cdd:COG2211  233 LLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLF 312

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 198247443  92 V--THNIWGIILARLLQGAG-----AVSSVLLATAGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGL 156
Cdd:COG2211  313 FlgPGNLWLLLVLAALAGIGlgailVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGL 384
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
41-322 1.07e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 50.24  E-value: 1.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  41 TPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQGAG-----AVSSVL 115
Cdd:COG0738   41 SDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGlglldVAANPY 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 116 LATAGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGLTGVFLVAAALGVLALLPLWKVIPPIPRNLQQRMGNW 195
Cdd:COG0738  121 VAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSA 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 196 RDALRIFRYPPVLTASVGIFILQMVLGASFVVLSPELVKAMHIPGSAVWEVYLPVMLLSVAGMLYPVIHAERHRQHGQML 275
Cdd:COG0738  201 ASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLR 280

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 198247443 276 VFSGLAIAagALFMGLLAGHFWPVAVGAVIFFTGynvASAILPSMMS 322
Cdd:COG0738  281 LSALLAAV--GLLLALLAPGPWLALIGLALVGLG---LSLMFPTIFS 322
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 28-153 1.12e-06

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 50.31  E-value: 1.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  28 PVLALDNDQLRHSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQG 107
Cdd:cd17328   19 AGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVG 98

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 198247443 108 AGAVSSVLLATA--GDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVF 153
Cdd:cd17328   99 IGEASYSPIAPTiiADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLV 146
emrD PRK11652
multidrug transporter EmrD;
52-109 1.33e-06

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 49.91  E-value: 1.33e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 198247443  52 YGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQGAG 109
Cdd:PRK11652  52 YLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLG 109
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 41-156 1.40e-06

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 50.05  E-value: 1.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443   41 TPVLLG--LAIGIYGLAQAALQFpfGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQ--GAGAVSSVLL 116
Cdd:TIGR00895  50 DPVQLGflFSAGLIGMAFGALFF--GPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAglGLGGLMPNLN 127

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 198247443  117 ATAGDLTGEQHRTKAMaaigGSIAIAYVLGMAMGPVFYGL 156
Cdd:TIGR00895 128 ALVSEYAPKRFRGTAV----GLMFCGYPIGAAVGGFLAGW 163
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 63-145 2.04e-06

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 49.61  E-value: 2.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  63 FGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQGAG-----AVSSVLLAtagDLTGEQHRTKAMAAIGG 137
Cdd:cd17371   54 GGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGfggewAAGAALMA---EYVPARHRGKALGYVQS 130


                 ....*...
gi 198247443 138 SIAIAYVL 145
Cdd:cd17371  131 GWAVGWLL 138
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 63-154 1.20e-05

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 46.80  E-value: 1.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  63 FGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQGAgAVSSVLLAT---AGDLTGEQHRTkaMAAIGGSi 139
Cdd:cd17317   45 FGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGV-TSAGIFTVGfvlGMEIVGPKYRS--FVGILFG- 120

                         90
                 ....*....|....*
gi 198247443 140 aIAYVLGMAMGPVFY 154
Cdd:cd17317  121 -LFWALGYMLLALLA 134
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
52-109 1.30e-05

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 46.86  E-value: 1.30e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 198247443  52 YGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQGAG 109
Cdd:PRK15402  57 YLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIG 114
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
48-146 1.36e-05

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 46.74  E-value: 1.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  48 AIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQGAgavSSVLLATAGDLT---- 123
Cdd:PRK15403  56 SVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGT---SICFIATVGYVTvqea 132

                         90       100
                 ....*....|....*....|....
gi 198247443 124 -GEQHRTKAMAAIGGSIAIAYVLG 146
Cdd:PRK15403 133 fGQTKGIKLMAIITSIVLVAPIIG 156
PRK14995 PRK14995
SmvA family efflux MFS transporter;
49-156 1.40e-05

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 47.03  E-value: 1.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  49 IGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQGAGA---VSSVLLATAGDLTGE 125
Cdd:PRK14995  47 IDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLIATRALLAIGAamiVPATLAGIRATFTEE 126

                         90       100       110
                 ....*....|....*....|....*....|....
gi 198247443 126 QHRTKAM---AAIGGSiaiayvlGMAMGPVFYGL 156
Cdd:PRK14995 127 KQRNMALgvwAAVGSG-------GAAFGPLVGGI 153
Sugar_tr pfam00083
Sugar (and other) transporter;
8-110 1.42e-05

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 46.88  E-value: 1.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443    8 AVAGLSFIYVARMLGLFMLMPVLALDNDQLRHSTP-----VLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLI 82
Cdd:pfam00083   6 ALGGFLFGYDTGVIGAFLTLIDFFKNFGLSKSVSSlaalsVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVL 85

                          90       100       110
                  ....*....|....*....|....*....|.
gi 198247443   83 FVLGSLLGAVTHNIWG---IILARLLQGAGA 110
Cdd:pfam00083  86 FVIGAVLQGAAKGKWSvyqLIVGRVLVGIGV 116
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 52-150 1.63e-05

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 46.99  E-value: 1.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443   52 YGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQG--AGAVSSVLLATAGDLTGEQHRT 129
Cdd:TIGR00711  46 YMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGfgGGPLIPLSFSTLLNIYPPEKRG 125

                          90       100
                  ....*....|....*....|.
gi 198247443  130 KAMAAIGGSIAIAYVLGMAMG 150
Cdd:TIGR00711 126 RAMAIWGLTVLVAPALGPTLG 146
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 21-150 2.09e-05

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 46.07  E-value: 2.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  21 LGLFMLMPVLALDNDQLrHSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGII 100
Cdd:cd17390   10 FGVSMILPLLSTHIRSL-GASPTVIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLF 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 198247443 101 LARLLQGA-GAVSSVLLATAGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMG 150
Cdd:cd17390   89 LSRIPLGIfKHTQSLCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVG 139
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 28-115 4.68e-05

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 45.26  E-value: 4.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  28 PVLALDNDQLRHSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQG 107
Cdd:cd17315   19 ALLYIAKDLGFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLG 98


                 ....*....
gi 198247443 108 AGA-VSSVL 115
Cdd:cd17315   99 LGVgLASVL 107
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
45-116 5.41e-05

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 44.91  E-value: 5.41e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 198247443  45 LGLAIGiyglaqaalQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQG-AGAVSSVLL 116
Cdd:PRK11102  37 LGFAIG---------QLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGlAAAAASVVI 100
MFS_SLC18A1_2_VAT1_2 cd17384
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ...
 64-163 5.59e-05

Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340942 [Multi-domain]  Cd Length: 373  Bit Score: 44.87  E-value: 5.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  64 GVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQGAG-AVSSV----LLATAgdLTGEQHRTKAMAAIGGS 138
Cdd:cd17384   52 GPLTNRIGYSLPMFVGFVIMFISTLLFAFGESYGVLFLARALQGVGsACSSVagmgMLASL--YPDDKERGKAMGIALGG 129

                         90       100
                 ....*....|....*....|....*
gi 198247443 139 IAIAYVLGMAMGPVFYGLSGLTGVF 163
Cdd:cd17384  130 LALGVLVGPPFGGVMYEFVGKSAPF 154
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 21-295 7.45e-05

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 44.46  E-value: 7.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  21 LGLFMLMPVLALDNDQLRHSTPVLLGLAIGIYGLAQAALQFPFGVASDR-FGRKRVLVFGLLIFVLGSLLGAVTHNIWG- 98
Cdd:cd17471   10 LAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRgGDRKPLILLALLAGALGYLLFAFLRNYWVl 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  99 -IILARLLQGAGAVSSVLLATA---GDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGLTGVFLVAAALGVLAL 174
Cdd:cd17471   90 lLVGVVLLSLGAAAFPQLFALAreyADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVA 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 175 LPLWKVIPPIPRNLQQRMGNWRDALRIFRyPPVLTASVGIFILQMVLGASFVVLSPELVKAMHIPGSAVWEVY------- 247
Cdd:cd17471  170 LLVLFLLPSVKPPAQKATPASSLVKAPVN-RRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLFglaaale 248

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 198247443 248 LPVMLLsvAGMLypvihAERHRQHGQMLVfsglAIAAGALFMGLLAGH 295
Cdd:cd17471  249 IPIMLL--AGLL-----AKRFGKRRLLLA----GFLAGVLFYLGLALA 285
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 41-150 7.76e-05

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 44.57  E-value: 7.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  41 TPVLLGLA--IGIYGLAQAAlqFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQGA--GAVSSVLL 116
Cdd:PRK11551  48 DVAQMGWAfsAGILGLLPGA--LLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVglGGALPNLI 125

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 198247443 117 ATAGDLTGEQHRTKAMAA------IGGsiAIAYVLGMAMG 150
Cdd:PRK11551 126 ALTSEAVGPRLRGTAVSLmycgvpFGG--ALASVIGVLAA 163
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 61-115 2.01e-04

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 43.33  E-value: 2.01e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 198247443  61 FPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQGA--GAVSSVL 115
Cdd:cd17358   59 LLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFggGAASVVV 115
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 39-153 3.50e-04

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 42.25  E-value: 3.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  39 HSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQGAGAvsSVLLAT 118
Cdd:cd17476   29 GTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGP--AFLLPN 106

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 198247443 119 AGDLTGEQH-----RTKAMAAIGGSIAIAYVLGMAMGPVF 153
Cdd:cd17476  107 AMALLGRTYppgprKNIVFSLFGATAPLGFALGGVFGGLF 146
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 64-109 4.27e-04

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 42.26  E-value: 4.27e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 198247443  64 GVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQGAG 109
Cdd:cd17360   56 GWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLG 101
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 26-236 7.08e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 41.39  E-value: 7.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  26 LMPVLAldndQLRHSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLL 105
Cdd:cd17478   18 LLPLLI----AKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVAL 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 106 QGAGavSSVL----LATAGDLTGEQhRTKAMA--AIGGSiaiayvLGMAMGPVF----YGLSGLTGVFLVAAALGVLALL 175
Cdd:cd17478   94 AGIG--SAAFhpegARLASQAAGGR-RGLAMSifSVGGN------LGFALGPLIaaalVALFGGLGLLILLIIPGLAVAL 164

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 198247443 176 PLWKVIPPIPRNLQQRMGNWRDALRIFRYPPVLTASVGIFILQMVLGASFVVLSPELVKAM 236
Cdd:cd17478  165 LLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQR 225
PRK03545 PRK03545
putative arabinose transporter; Provisional
 46-305 7.77e-04

putative arabinose transporter; Provisional


Pssm-ID: 179591 [Multi-domain]  Cd Length: 390  Bit Score: 41.41  E-value: 7.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  46 GLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARL-LQGAGAVS-SVLLATAGDLT 123
Cdd:PRK03545  47 GLMLTIYAWVVALMSLPLMLLTSNVERRKLLIGLFVLFIASHVLSALAWNFTVLLISRIgIAFAHAIFwSITASLAIRVA 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 124 GEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGLTGVFLVAAALGVLALLPLWKVIPPIPrnlQQRMGNWRDALRIFR 203
Cdd:PRK03545 127 PAGKKAQALSLLATGTALAMVLGLPLGRVIGQYLGWRTTFLAIGGGALITLLLLIKLLPLLP---SEHSGSLKSLPLLFR 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 204 YPpvltASVGIFILQM-VLGASFVVLS---PELVKAMHIPGSAVWEVYLpvmLLSVAGMLYPVIHAERHRQH-GQMLVFS 278
Cdd:PRK03545 204 RP----ALVSLYLLTVvVVTAHFTAYSyiePFVQQVAGLSENFATLLLL---LFGGAGIIGSVLFSRLGNRHpSGFLLIA 276

                        250       260
                 ....*....|....*....|....*..
gi 198247443 279 GLAIAAGALFMGLLAGHFWPVAVGAVI 305
Cdd:PRK03545 277 IALLLVCLLLLLPAANSEWHLSVLSIF 303
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 12-142 7.90e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 41.41  E-value: 7.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  12 LSFIYVARMLGLFMLMPVLAldnDQLRHSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGA 91
Cdd:cd17503  186 LSFLLGLGLFGAMFLLPLYL---QNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTLLLA 262

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 198247443  92 VTH---NIWGIILARLLQGAG-AVSSVLLATAGDLTGEQHRTKAMAAI-------GGSIAIA 142
Cdd:cd17503  263 FLTpdtSLWLIILPLFIRGLGmGLVFMPLNTLALNSLPPEQIGDATALfntirqlGGSIGTA 324
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 39-109 1.38e-03

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 40.63  E-value: 1.38e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 198247443  39 HSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQGAG 109
Cdd:cd17359   32 NLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLA 102
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 33-110 1.40e-03

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 40.70  E-value: 1.40e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 198247443  33 DNDQLRHSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLG-AVTHNIWGIILARLLQGAGA 110
Cdd:cd17356   35 DNTGTYYPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQvAAIGKWYQLIVGRIIAGLGV 113
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 7-163 1.44e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 40.29  E-value: 1.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443   7 RAVAGLSFIYVARMLGLFMLMPVLALDNDQLRHSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLG 86
Cdd:cd17329  200 RAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIG 279

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 198247443  87 SLLGAVTHNIWGIILARLLQGAG--AVSSVLLATAGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGLTGVF 163
Cdd:cd17329  280 FAVLAFANTLAVLILAMIVLTLGemLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPW 358
PRK11646 PRK11646
multidrug efflux MFS transporter MdtH;
21-109 2.03e-03

multidrug efflux MFS transporter MdtH;


Pssm-ID: 183255  Cd Length: 400  Bit Score: 40.04  E-value: 2.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  21 LGLFMLMPVLALD-NDQLRHsTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGI 99
Cdd:PRK11646  24 LGFFVVFPLISIRfVDQLGW-AAVMVGIALGLRQFIQQGLGIFGGAIADRFGAKPMIVTGMLMRAAGFATMAIAHEPWLL 102

                         90
                 ....*....|
gi 198247443 100 ILARLLQGAG 109
Cdd:PRK11646 103 WLSCILSGLG 112
MFS_1 pfam07690
Major Facilitator Superfamily;
12-151 3.23e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 39.32  E-value: 3.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443   12 LSFIYVARMLGLFMLMPVLAldndQLRHSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGA 91
Cdd:pfam07690 208 ALLLFGFAFFGLLTYLPLYQ----EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLL 283

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 198247443   92 VTHNIWGIILARLLQ-----GAGAVSSVLLATAGDLTGEQHRTKAMAAIGgsiaIAYVLGMAMGP 151
Cdd:pfam07690 284 LLSLTLSSLWLLLALlllgfGFGLVFPALNALVSDLAPKEERGTASGLYN----TAGSLGGALGP 344
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 46-163 4.31e-03

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 39.15  E-value: 4.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  46 GLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQGAG--AVSSVLLATAGDLT 123
Cdd:cd17313  284 AWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGwaTININPYPLVSDYH 363

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 198247443 124 GEQHRT--KAMAAIGGSIAIAYVLG----------------MAMGPVFYGLSGLTGVF 163
Cdd:cd17313  364 SESGRGqgTDTGLLNLAISLAQILVsllagpiidvkgygtvFPVAAVASFLSLVGALF 421
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 7-158 4.71e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 38.71  E-value: 4.71e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443   7 RAVAGLSFIYVARMLGLFMLMPVLALDNDQLRHSTPVLLGLAIGIYGLAQAALQFPF-GVASDRFGRKRVLVFGLLIFVL 85
Cdd:cd17330  174 PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLiPRLAKRLGERKLLRLGLLLAII 253

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 198247443  86 GSLLGAVTHNIWGIILARLLQGAGA--VSSVLLATAGDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSG 158
Cdd:cd17330  254 GLLLLPFASSVPLLVLAAAILAFGTgiVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLG 328
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 60-184 5.07e-03

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 38.69  E-value: 5.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  60 QFPFGVASDRFGRKRVLVFGLLIFVLGSLLG--AVTHNIWGIILARLLQGAGavSSVLLATAGDLTG----EQHRTKAMA 133
Cdd:cd17380   51 QVLGGYLADRFGGKKVLLLAVALWSLATLLTplLAYSSLPLLILSRILLGLG--EGVHFPSMTSLFSrwvpVSERSRAVS 128

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 198247443 134 AIGGSIAIAYVLGMAMGPVFYGLSGLTGVFLVAAALGVLALLPLWKVIPPI 184
Cdd:cd17380  129 IVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYLPPV 179
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 36-147 5.55e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 38.75  E-value: 5.55e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  36 QLRHSTPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVL-VFGLLIFVLGSLLGAVTHNIWGIILARLLQGA--GAVS 112
Cdd:cd17353  242 EFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLsIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFcyGGGF 321

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 198247443 113 SVLLATAGDLTGEQHRT---------KAMAAIGGSIAIAYVLGM 147
Cdd:cd17353  322 ALFPALTADFFGTKNAGtnygllytaKGVGGLIGPIIAAYVLYT 365
MFS_ARN_like cd17322
Yeast ARN family of Siderophore iron transporters and similar proteins of the Major ...
 57-140 5.56e-03

Yeast ARN family of Siderophore iron transporters and similar proteins of the Major Facilitator Superfamily; The ARN family of siderophore iron transporters includes ARN1 (or ferrichrome permease), ARN2 (or triacetylfusarinine C transporter 1 or TAF1), ARN3 (or siderophore iron transporter 1 or SIT1 or ferrioxamine B permease) and ARN4 (or Enterobactin permease or ENB1). They specifically recognize siderophore-iron chelates are expressed under conditions of iron deprivation. They facilitate the uptake of both hydroxamate- and catecholate-type siderophores. This group also includes glutathione exchanger 1 (Gex1p) and Gex2p, which are proton/glutathione antiporters that import glutathione from the vacuole and exports it through the plasma membrane. The ARN family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340880 [Multi-domain]  Cd Length: 514  Bit Score: 38.83  E-value: 5.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  57 AALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQGAGAVSSVLLAT--AGDLTGEQHRTKAMAA 134
Cdd:cd17322   51 AVSQPPYAKLSDVFGRLELFLVSLLLYVVGTIIMAASTNVQTYAAGSVFYNAGYTGLNLLLTliLADFSSLKNRGFASAI 130

                         90
                 ....*....|....*.
gi 198247443 135 ----------IGGSIA 140
Cdd:cd17322  131 pslpyiittwIGGNIA 146
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 44-142 5.59e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 38.79  E-value: 5.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  44 LLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLL---QGAGAVSSVLLATAG 120
Cdd:cd17355   39 VISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLlggGGAGTLAAVAFATVA 118

                         90       100
                 ....*....|....*....|..
gi 198247443 121 DLTGEQHRTKAMAAIGGSIAIA 142
Cdd:cd17355  119 AWWFERRRGLALGILTAGGGLG 140
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 63-146 5.61e-03

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 38.84  E-value: 5.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443   63 FGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQGAG----AVSSVLLATagDLTGEQHRTKamaaIGGS 138
Cdd:TIGR00898 147 FGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGiggiWVQAVVLNT--EFLPKKQRAI----VGTL 220


                  ....*...
gi 198247443  139 IAIAYVLG 146
Cdd:TIGR00898 221 IQVFFSLG 228
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 4-163 5.73e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 38.71  E-value: 5.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443   4 FEKRAVAGLSFIYVARMLGLFMLMPVLALDNDQLRHSTPVLLGLAIGIYGLAQAALQFPFG-VASDRFGRKRVLVFGLLI 82
Cdd:cd17474  195 LRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGrLLKKRFGARRILVIGLLL 274

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  83 FVLGSLLGAVTHNIWGIILARLLQGA--GAVSSVLLATAGDLTGEQHRTKAMAAIGgsiaIAYVLGMAMGPVFYGL---- 156
Cdd:cd17474  275 YALSLLLLGFVPSLALLLIAIVLFGLglGLNLPLLTTLVTELAPEEERGTASSLYN----FVRFLGQAVGPLLFGLllei 350


                 ....*..
gi 198247443 157 SGLTGVF 163
Cdd:cd17474  351 FGLSAPF 357
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 63-229 7.47e-03

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 38.33  E-value: 7.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  63 FGVASDRFG-RKRVLVFGLLIFVLG-SLLGAVTHNIWGIILARLLQGAGA------VSSVLLATAGDLTGEQHRTKAMAA 134
Cdd:cd17335   52 WGALADRFGkRKALLLLSLLAAVLFfLSLFFVAQIFWLLLLLVILGAFFSapvvplVDSITLQYLGEERERYGKQRLWGS 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 135 IGGSIAiAYVLGMAMGpVFYGLSGLTGVFLVAAALGVLALLPLWKVipPIPRNLQQRMGNWRDALRIFRYPPVLTASVGI 214
Cdd:cd17335  132 IGFGIA-ALLVGILID-RSSTYKNYTIAFYVFAVLMLLALLLALKF--PFRPKHPEPNENTGGLLALLRNPRVLAFLLVA 207

                        170
                 ....*....|....*
gi 198247443 215 FILQMVLGASFVVLS 229
Cdd:cd17335  208 FLMGFGHGLIYSFLF 222
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
41-168 7.70e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 38.32  E-value: 7.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  41 TPVLLGLAIGIYGLAQAALQFPFGVASDRFGRKRVLVFGLLIFVLGS-LLGAVTHNIWGIILARLLqgAGAVSSVLLATA 119
Cdd:COG2223  239 SAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLlLLALALGSLWLFLVLFLL--LGLALGGGNGAV 316

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 198247443 120 GDLTGEQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLS-----GLTGVFLVAAA 168
Cdd:COG2223  317 FALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALldatgSYTAAFLVFAV 370
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 47-309 9.28e-03

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 37.95  E-value: 9.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  47 LAIGIYGLAQAALQFpfGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARLLQGA--GAVSSVLLATAGDLTG 124
Cdd:cd17365   40 GSAALFGMAIGALLA--GPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLglGAAMPNAITLVSEYAP 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 125 EQHRTKAMAAIGGSIAIAYVLGMAMGPVFYGLSGLTGVFLVAaalgvlallplwkVIPPIPrnlqqrmgnwrdalrifrY 204
Cdd:cd17365  118 ARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLG-------------GVPPLI------------------L 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443 205 PPVLTASVGIFILQMVLGASFVVLSPELVKAMHIPGSAVWEVYLPVMLLSVAGMLYPVIH---AERHRQHGQMLVFSGLA 281
Cdd:cd17365  167 LPLLRGTLLLWVTFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLgwlADRFGPKRVLALFFALG 246

                        250       260
                 ....*....|....*....|....*...
gi 198247443 282 iaaGALFMGLLAGHFWPVAVGAVIFFTG 309
Cdd:cd17365  247 ---AVSLALLGVSPASLVLLYVLVFLAG 271
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 63-156 9.43e-03

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 37.97  E-value: 9.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 198247443  63 FGVASDRFGRKRVLVFGLLIFVLGSLLGAVTHNIWGIILARL-------LQGAGAVSSvllatagDLTGEQHRTKAMaai 135
Cdd:cd17331   55 FGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRLpsvfmhaMQAAQMVVT-------DLTDPGERAAAL--- 124

                         90       100
                 ....*....|....*....|.
gi 198247443 136 gGSIAIAYVLGMAMGPVFYGL 156
Cdd:cd17331  125 -GRLGLSYGIGMVVGSFLGGL 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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