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Conserved domains on  [gi|197927121|ref|NP_001128200|]
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sperm-associated antigen 16 protein isoform 2 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 23-309 1.37e-77

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 238.39  E-value: 1.37e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121  23 LNNIFRLHELPVSCIVMHPFRDYLVSCSEDRLWKMVGLPKGNVILTGSGHSDWLSDCCFHPSGSKLATSSGDSTIKLWDL 102
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121 103 SKGECILTFAGHNHAIWSCTWHSCGDFVASASLDMTSKIWDVNSERCRYTLYGHTDSVNSIEFFPFSNTLLTASADKTLS 182
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121 183 VWDARTGKCEQSLYGHMHSVNDATFTPRGHILASCDSRGVIKLWDFRKLIPIVSIDVGPSPGNEVNFDPSGRVLAQASAN 262
Cdd:cd00200  161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 197927121 263 GIIHLLDLKSGQIHK-LVGHESEVHTVIFSHRAENLYSGGSDGTIRLW 309
Cdd:cd00200  241 GTIRVWDLRTGECVQtLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 23-309 1.37e-77

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 238.39  E-value: 1.37e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121  23 LNNIFRLHELPVSCIVMHPFRDYLVSCSEDRLWKMVGLPKGNVILTGSGHSDWLSDCCFHPSGSKLATSSGDSTIKLWDL 102
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121 103 SKGECILTFAGHNHAIWSCTWHSCGDFVASASLDMTSKIWDVNSERCRYTLYGHTDSVNSIEFFPFSNTLLTASADKTLS 182
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121 183 VWDARTGKCEQSLYGHMHSVNDATFTPRGHILASCDSRGVIKLWDFRKLIPIVSIDVGPSPGNEVNFDPSGRVLAQASAN 262
Cdd:cd00200  161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 197927121 263 GIIHLLDLKSGQIHK-LVGHESEVHTVIFSHRAENLYSGGSDGTIRLW 309
Cdd:cd00200  241 GTIRVWDLRTGECVQtLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
22-309 5.23e-76

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 237.89  E-value: 5.23e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121  22 RLNNIFRLHELPVSCIVMHPFRDYLVSCSED---RLWKmvgLPKGNVILTGSGHSDWLSDCCFHPSGSKLATSSGDSTIK 98
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADgtvRLWD---LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVR 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121  99 LWDLSKGECILTFAGHNHAIWSCTWHSCGDFVASASLDMTSKIWDVNSERCRYTLYGHTDSVNSIEFFPFSNTLLTASAD 178
Cdd:COG2319  188 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121 179 KTLSVWDARTGKCEQSLYGHMHSVNDATFTPRGHILASCDSRGVIKLWDFRKLIPIVSIDVGPSPGNEVNFDPSGRVLAQ 258
Cdd:COG2319  268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 197927121 259 ASANGIIHLLDLKSGQ-IHKLVGHESEVHTVIFSHRAENLYSGGSDGTIRLW 309
Cdd:COG2319  348 GSDDGTVRLWDLATGElLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
PTZ00421 PTZ00421
coronin; Provisional
 78-237 4.06e-11

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 63.37  E-value: 4.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121  78 DCCFHP-SGSKLATSSGDSTIKLWDL-------SKGECILTFAGHNHAIWSCTWH-SCGDFVASASLDMTSKIWDVNSER 148
Cdd:PTZ00421  80 DVAFNPfDPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHpSAMNVLASAGADMVVNVWDVERGK 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121 149 CRYTLYGHTDSVNSIEFFPFSNTLLTASADKTLSVWDARTGKCEQSLYGHMHSVND-ATFTPRGHILAS-----CDSRGv 222
Cdd:PTZ00421 160 AVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQrCLWAKRKDLIITlgcskSQQRQ- 238

                        170
                 ....*....|....*
gi 197927121 223 IKLWDFRKLIPIVSI 237
Cdd:PTZ00421 239 IMLWDTRKMASPYST 253
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 62-101 1.99e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 1.99e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 197927121    62 KGNVILTGSGHSDWLSDCCFHPSGSKLATSSGDSTIKLWD 101
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
105-143 3.83e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 3.83e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 197927121  105 GECILTFAGHNHAIWSCTWHSCGDFVASASLDMTSKIWD 143
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 23-309 1.37e-77

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 238.39  E-value: 1.37e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121  23 LNNIFRLHELPVSCIVMHPFRDYLVSCSEDRLWKMVGLPKGNVILTGSGHSDWLSDCCFHPSGSKLATSSGDSTIKLWDL 102
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121 103 SKGECILTFAGHNHAIWSCTWHSCGDFVASASLDMTSKIWDVNSERCRYTLYGHTDSVNSIEFFPFSNTLLTASADKTLS 182
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121 183 VWDARTGKCEQSLYGHMHSVNDATFTPRGHILASCDSRGVIKLWDFRKLIPIVSIDVGPSPGNEVNFDPSGRVLAQASAN 262
Cdd:cd00200  161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSED 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 197927121 263 GIIHLLDLKSGQIHK-LVGHESEVHTVIFSHRAENLYSGGSDGTIRLW 309
Cdd:cd00200  241 GTIRVWDLRTGECVQtLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
22-309 5.23e-76

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 237.89  E-value: 5.23e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121  22 RLNNIFRLHELPVSCIVMHPFRDYLVSCSED---RLWKmvgLPKGNVILTGSGHSDWLSDCCFHPSGSKLATSSGDSTIK 98
Cdd:COG2319  111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADgtvRLWD---LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVR 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121  99 LWDLSKGECILTFAGHNHAIWSCTWHSCGDFVASASLDMTSKIWDVNSERCRYTLYGHTDSVNSIEFFPFSNTLLTASAD 178
Cdd:COG2319  188 LWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121 179 KTLSVWDARTGKCEQSLYGHMHSVNDATFTPRGHILASCDSRGVIKLWDFRKLIPIVSIDVGPSPGNEVNFDPSGRVLAQ 258
Cdd:COG2319  268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 197927121 259 ASANGIIHLLDLKSGQ-IHKLVGHESEVHTVIFSHRAENLYSGGSDGTIRLW 309
Cdd:COG2319  348 GSDDGTVRLWDLATGElLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
22-309 4.03e-73

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 230.57  E-value: 4.03e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121  22 RLNNIFRLHELPVSCIVMHPFRDYLVSCSEDRLWKMVGLPKGNVILTGSGHSDWLSDCCFHPSGSKLATSSGDSTIKLWD 101
Cdd:COG2319   69 ALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121 102 LSKGECILTFAGHNHAIWSCTWHSCGDFVASASLDMTSKIWDVNSERCRYTLYGHTDSVNSIEFFPFSNTLLTASADKTL 181
Cdd:COG2319  149 LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTV 228

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121 182 SVWDARTGKCEQSLYGHMHSVNDATFTPRGHILASCDSRGVIKLWDFRKLIPIVSIDVGPSPGNEVNFDPSGRVLAQASA 261
Cdd:COG2319  229 RLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSD 308

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 197927121 262 NGIIHLLDLKSGQ-IHKLVGHESEVHTVIFSHRAENLYSGGSDGTIRLW 309
Cdd:COG2319  309 DGTVRLWDLATGKlLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
27-309 1.48e-65

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 211.31  E-value: 1.48e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121  27 FRLHELPVSCIVMHPFRDYLVSCSEDRLWKMVGLPKGNVILTGSGHSDWLSDCCFHPSGSKLATSSGDSTIKLWDLSKGE 106
Cdd:COG2319   32 LLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGL 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121 107 CILTFAGHNHAIWSCTWHSCGDFVASASLDMTSKIWDVNSERCRYTLYGHTDSVNSIEFFPFSNTLLTASADKTLSVWDA 186
Cdd:COG2319  112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121 187 RTGKCEQSLYGHMHSVNDATFTPRGHILASCDSRGVIKLWDFRKLIPIVSIDVGPSPGNEVNFDPSGRVLAQASANGIIH 266
Cdd:COG2319  192 ATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVR 271

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 197927121 267 LLDLKSGQ-IHKLVGHESEVHTVIFSHRAENLYSGGSDGTIRLW 309
Cdd:COG2319  272 LWDLATGElLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
41-309 3.02e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 189.74  E-value: 3.02e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121  41 PFRDYLVSCSEDRLWKMVGLPKGNVILTGSGHSDWLSDCCFHPSGSKLATSSGDSTIKLWDLSKGECILTFAGHNHAIWS 120
Cdd:COG2319    4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121 121 CTWHSCGDFVASASLDMTSKIWDVNSERCRYTLYGHTDSVNSIEFFPFSNTLLTASADKTLSVWDARTGKCEQSLYGHMH 200
Cdd:COG2319   84 VAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSG 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121 201 SVNDATFTPRGHILASCDSRGVIKLWDFRKLIPIVSIDVGPSPGNEVNFDPSGRVLAQASANGIIHLLDLKSGQ-IHKLV 279
Cdd:COG2319  164 AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKlLRTLT 243

                        250       260       270
                 ....*....|....*....|....*....|
gi 197927121 280 GHESEVHTVIFSHRAENLYSGGSDGTIRLW 309
Cdd:COG2319  244 GHSGSVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 25-227 5.81e-53

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 175.22  E-value: 5.81e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121  25 NIFRLHELPVSCIVMHPFRDYLVSCSEDRLWKMVGLPKGNVILTGSGHSDWLSDCCFHPSGSKLATSSGDSTIKLWDLSK 104
Cdd:cd00200   87 RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121 105 GECILTFAGHNHAIWSCTWHSCGDFVASASLDMTSKIWDVNSERCRYTLYGHTDSVNSIEFFPFSNTLLTASADKTLSVW 184
Cdd:cd00200  167 GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 197927121 185 DARTGKCEQSLYGHMHSVNDATFTPRGHILASCDSRGVIKLWD 227
Cdd:cd00200  247 DLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
81-309 9.85e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 151.60  E-value: 9.85e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121  81 FHPSGSKLATSSGDSTIKLWDLSKGECILTFAGHNHAIWSCTWHSCGDFVASASLDMTSKIWDVNSERCRYTLYGHTDSV 160
Cdd:COG2319    2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121 161 NSIEFFPFSNTLLTASADKTLSVWDARTGKCEQSLYGHMHSVNDATFTPRGHILASCDSRGVIKLWDFRKLIPIVSIDVG 240
Cdd:COG2319   82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGH 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121 241 PSPGNEVNFDPSGRVLAQASANGIIHLLDLKSGQ-IHKLVGHESEVHTVIFSHRAENLYSGGSDGTIRLW 309
Cdd:COG2319  162 SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKlLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231
WD40 COG2319
WD40 repeat [General function prediction only];
22-146 1.97e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.91  E-value: 1.97e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121  22 RLNNIFRLHELPVSCIVMHPFRDYLVSCSED---RLWKmvgLPKGNVILTGSGHSDWLSDCCFHPSGSKLATSSGDSTIK 98
Cdd:COG2319  279 ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDgtvRLWD---LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVR 355

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 197927121  99 LWDLSKGECILTFAGHNHAIWSCTWHSCGDFVASASLDMTSKIWDVNS 146
Cdd:COG2319  356 LWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 22-143 5.64e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.95  E-value: 5.64e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121  22 RLNNIFRLHELPVSCIVMHPFRDYLVSCSEDRLWKMVGLPKGNVILTGSGHSDWLSDCCFHPSGSKLATSSGDSTIKLWD 101
Cdd:cd00200  168 KCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWD 247

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 197927121 102 LSKGECILTFAGHNHAIWSCTWHSCGDFVASASLDMTSKIWD 143
Cdd:cd00200  248 LRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PTZ00421 PTZ00421
coronin; Provisional
 78-237 4.06e-11

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 63.37  E-value: 4.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121  78 DCCFHP-SGSKLATSSGDSTIKLWDL-------SKGECILTFAGHNHAIWSCTWH-SCGDFVASASLDMTSKIWDVNSER 148
Cdd:PTZ00421  80 DVAFNPfDPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHpSAMNVLASAGADMVVNVWDVERGK 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121 149 CRYTLYGHTDSVNSIEFFPFSNTLLTASADKTLSVWDARTGKCEQSLYGHMHSVND-ATFTPRGHILAS-----CDSRGv 222
Cdd:PTZ00421 160 AVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQrCLWAKRKDLIITlgcskSQQRQ- 238

                        170
                 ....*....|....*
gi 197927121 223 IKLWDFRKLIPIVSI 237
Cdd:PTZ00421 239 IMLWDTRKMASPYST 253
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 62-101 1.99e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 1.99e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 197927121    62 KGNVILTGSGHSDWLSDCCFHPSGSKLATSSGDSTIKLWD 101
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 104-143 2.35e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 2.35e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 197927121   104 KGECILTFAGHNHAIWSCTWHSCGDFVASASLDMTSKIWD 143
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 146-185 2.62e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 2.62e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 197927121   146 SERCRYTLYGHTDSVNSIEFFPFSNTLLTASADKTLSVWD 185
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 76-207 2.70e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.01  E-value: 2.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121  76 LSDCCFHPS-GSKLATSSGDSTIKLWDLSKGECILTFAGHNHAIWSCTWHSCG-DFVASASLDMTSKIWDVN-------- 145
Cdd:PLN00181 535 LSGICWNSYiKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINqgvsigti 614

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121 146 ------------SERCRY-----------------------TLYGHTDSVNSIEFFPfSNTLLTASADKTLSVWD---AR 187
Cdd:PLN00181 615 ktkaniccvqfpSESGRSlafgsadhkvyyydlrnpklplcTMIGHSKTVSYVRFVD-SSTLVSSSTDNTLKLWDlsmSI 693

                        170       180
                 ....*....|....*....|
gi 197927121 188 TGKCEQSLYGHMHSVNDATF 207
Cdd:PLN00181 694 SGINETPLHSFMGHTNVKNF 713
WD40 pfam00400
WD domain, G-beta repeat;
105-143 3.83e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 3.83e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 197927121  105 GECILTFAGHNHAIWSCTWHSCGDFVASASLDMTSKIWD 143
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
63-101 1.00e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.00e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 197927121   63 GNVILTGSGHSDWLSDCCFHPSGSKLATSSGDSTIKLWD 101
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
148-185 1.28e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 1.28e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 197927121  148 RCRYTLYGHTDSVNSIEFFPFSNTLLTASADKTLSVWD 185
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 188-227 4.76e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 4.76e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 197927121   188 TGKCEQSLYGHMHSVNDATFTPRGHILASCDSRGVIKLWD 227
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 130-309 3.60e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.46  E-value: 3.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121 130 VASASLDMTSKIWDVNSERCRYTLYGHTDSVNSIEFfpfsntlltASADKTLsvwdartgkceqslyghmhsvndatftp 209
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDY---------SSADPTL---------------------------- 590

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121 210 rghiLASCDSRGVIKLWDFRKLIPIVSIDvgpSPGNE--VNF-DPSGRVLAQASANGIIHLLDLKSGQIH--KLVGHESE 284
Cdd:PLN00181 591 ----LASGSDDGSVKLWSINQGVSIGTIK---TKANIccVQFpSESGRSLAFGSADHKVYYYDLRNPKLPlcTMIGHSKT 663

                        170       180
                 ....*....|....*....|....*
gi 197927121 285 VHTVIFSHrAENLYSGGSDGTIRLW 309
Cdd:PLN00181 664 VSYVRFVD-SSTLVSSSTDNTLKLW 687
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 274-309 3.68e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 3.68e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 197927121   274 QIHKLVGHESEVHTVIFSHRAENLYSGGSDGTIRLW 309
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PTZ00421 PTZ00421
coronin; Provisional
 71-143 9.58e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 43.73  E-value: 9.58e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 197927121  71 GHSDWLSDCCFHPSGSKLATSSG-DSTIKLWDLSKGECILTFAGHNHAIWSCTWHSCGDFVASASLDMTSKIWD 143
Cdd:PTZ00421 123 GHTKKVGIVSFHPSAMNVLASAGaDMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIID 196
WD40 pfam00400
WD domain, G-beta repeat;
274-309 1.73e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 1.73e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 197927121  274 QIHKLVGHESEVHTVIFSHRAENLYSGGSDGTIRLW 309
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
189-227 2.24e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 2.24e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 197927121  189 GKCEQSLYGHMHSVNDATFTPRGHILASCDSRGVIKLWD 227
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 71-243 3.66e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.86  E-value: 3.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121  71 GHSDWLSDCCFHPSGSK-LATSSGDSTIKLWDLSKGE----------CILTfaGHNHAIWSCTWHSCGDFV-ASASLDMT 138
Cdd:PTZ00420  72 GHTSSILDLQFNPCFSEiLASGSEDLTIRVWEIPHNDesvkeikdpqCILK--GHKKKISIIDWNPMNYYImCSSGFDSF 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121 139 SKIWDVNSERCRYTLYgHTDSVNSIEFFPFSNTLLTASADKTLSVWDARTGKCEQSLYGHMHSVN------DATFTPRGH 212
Cdd:PTZ00420 150 VNIWDIENEKRAFQIN-MPKKLSSLKWNIKGNLLSGTCVGKHMHIIDPRKQEIASSFHIHDGGKNtkniwiDGLGGDDNY 228

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 197927121 213 ILASCDSRG---VIKLWDFRKL---IPIVSIDVGPSP 243
Cdd:PTZ00420 229 ILSTGFSKNnmrEMKLWDLKNTtsaLVTMSIDNASAP 265
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
174-306 2.64e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 38.52  E-value: 2.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121 174 TASADKTLSVWDARTGKCEQSLYGHMHSVnDATFTPRG-HILASCDSRGVIKLWDFRKLIPIVSIDVGPSPgNEVNFDPS 252
Cdd:COG3391   85 ANSGSGRVSVIDLATGKVVATIPVGGGPR-GLAVDPDGgRLYVADSGNGRVSVIDTATGKVVATIPVGAGP-HGIAVDPD 162

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 197927121 253 GRVLAQASANG-----IIHLLDLKSGQIHKLVGHESEVHTVIFSHRAENLY--------SGGSDGTI 306
Cdd:COG3391  163 GKRLYVANSGSntvsvIVSVIDTATGKVVATIPVGGGPVGVAVSPDGRRLYvanrgsntSNGGSNTV 229
PTZ00420 PTZ00420
coronin; Provisional
 97-190 4.60e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 38.39  E-value: 4.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197927121  97 IKLWDLSKGECILTFAGHNHAIWSCTWHSC-GDFVASASLDMTSKIWDV--NSERCRYT------LYGHTDSVNSIEFFP 167
Cdd:PTZ00420  56 IRLENQMRKPPVIKLKGHTSSILDLQFNPCfSEILASGSEDLTIRVWEIphNDESVKEIkdpqciLKGHKKKISIIDWNP 135

                         90       100
                 ....*....|....*....|....
gi 197927121 168 FSNTLLTASA-DKTLSVWDARTGK 190
Cdd:PTZ00420 136 MNYYIMCSSGfDSFVNIWDIENEK 159
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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