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Conserved domains on  [gi|197631975|gb|ACH70711|]
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SET and MYND domain containing 1b [Salmo salar]

Protein Classification

histone-lysine N-methyltransferase SMYD1( domain architecture ID 14410430)

histone-lysine N-methyltransferase SMYD1 methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation

CATH:  2.170.270.10
EC:  2.1.1.354
Gene Ontology:  GO:0032259|GO:0042054|GO:0046872|GO:1904047
PubMed:  16086857|25580534|25125178|34555372|24710145
SCOP:  4000530

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET_SMYD1 cd10526
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 ...
 3-269 6.25e-125

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 (SMYD1) and similar proteins; SMYD1 (EC 2.1.1.43), also termed BOP, is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD1 plays a critical role in cardiomyocyte differentiation, cardiac morphogenesis and myofibril organization, as well as in the regulation of endothelial cells (ECs). It is expressed in vascular endothelial cells, it has beenshown that knockdown of SMYD1 in endothelial cells impairs EC migration and tube formation.


:

Pssm-ID: 380924 [Multi-domain]  Cd Length: 210  Bit Score: 355.18  E-value: 6.25e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975   3 NVEVFDSPGKGRGLRATKELLSGDVLFSEPPFAAVVFdsladkichscfrrqdklqrcgqckfaqycdktcqsagwkehk 82
Cdd:cd10526    2 GVEVFTSEGKGRGLKATKEFWAGDVIFAEPPYAAVVF------------------------------------------- 38

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975  83 lecgaikafgaigdnfGKAPNENIRLAARIMWRLDKEGGVMSDMQMTSLDDLENHISDMPEDDLKELKVDIHNFLDYWPR 162
Cdd:cd10526   39 ----------------GKAPNENIRLAARILWRIEREGGGLKEGELVSIEDLQDHLEDFSEEEKKDLREDVHSFLDYWPY 102

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975 163 NSKQHRVDDISHIFGVINCNGFTVSDQRGLNAVGVGLFPNLCLVNHDCWPNCTVILNHGKIELRALGKIEPGEEVTVSYV 242
Cdd:cd10526  103 QSQQFSMEYISHIFGVINCNGFTLSDQRGLQAVGVGIFPNLCLVNHDCWPNCTVIFNNGRIELRALGKISEGDELTVSYI 182

                        250       260
                 ....*....|....*....|....*..
gi 197631975 243 DFLNVTEDRQRQLKMHYFFDCTCEHCK 269
Cdd:cd10526  183 DFLNTSEDRKEQLKKQYYFDCTCEHCT 209
zf-MYND pfam01753
MYND finger;
47-85 4.12e-14

MYND finger;


:

Pssm-ID: 460312  Cd Length: 39  Bit Score: 65.13  E-value: 4.12e-14
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 197631975   47 CHSCFRRQDKLQRCGQCKFAQYCDKTCQSAGWKEHKLEC 85
Cdd:pfam01753   1 CAVCGKEALKLLRCSRCKSVYYCSKECQKADWPYHKKEC 39
 
Name Accession Description Interval E-value
SET_SMYD1 cd10526
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 ...
 3-269 6.25e-125

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 (SMYD1) and similar proteins; SMYD1 (EC 2.1.1.43), also termed BOP, is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD1 plays a critical role in cardiomyocyte differentiation, cardiac morphogenesis and myofibril organization, as well as in the regulation of endothelial cells (ECs). It is expressed in vascular endothelial cells, it has beenshown that knockdown of SMYD1 in endothelial cells impairs EC migration and tube formation.


Pssm-ID: 380924 [Multi-domain]  Cd Length: 210  Bit Score: 355.18  E-value: 6.25e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975   3 NVEVFDSPGKGRGLRATKELLSGDVLFSEPPFAAVVFdsladkichscfrrqdklqrcgqckfaqycdktcqsagwkehk 82
Cdd:cd10526    2 GVEVFTSEGKGRGLKATKEFWAGDVIFAEPPYAAVVF------------------------------------------- 38

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975  83 lecgaikafgaigdnfGKAPNENIRLAARIMWRLDKEGGVMSDMQMTSLDDLENHISDMPEDDLKELKVDIHNFLDYWPR 162
Cdd:cd10526   39 ----------------GKAPNENIRLAARILWRIEREGGGLKEGELVSIEDLQDHLEDFSEEEKKDLREDVHSFLDYWPY 102

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975 163 NSKQHRVDDISHIFGVINCNGFTVSDQRGLNAVGVGLFPNLCLVNHDCWPNCTVILNHGKIELRALGKIEPGEEVTVSYV 242
Cdd:cd10526  103 QSQQFSMEYISHIFGVINCNGFTLSDQRGLQAVGVGIFPNLCLVNHDCWPNCTVIFNNGRIELRALGKISEGDELTVSYI 182

                        250       260
                 ....*....|....*....|....*..
gi 197631975 243 DFLNVTEDRQRQLKMHYFFDCTCEHCK 269
Cdd:cd10526  183 DFLNTSEDRKEQLKKQYYFDCTCEHCT 209
zf-MYND pfam01753
MYND finger;
47-85 4.12e-14

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 65.13  E-value: 4.12e-14
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 197631975   47 CHSCFRRQDKLQRCGQCKFAQYCDKTCQSAGWKEHKLEC 85
Cdd:pfam01753   1 CAVCGKEALKLLRCSRCKSVYYCSKECQKADWPYHKKEC 39
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
184-271 9.80e-10

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 55.74  E-value: 9.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975 184 FTVSDQRGLNAVGVGlfPNLCLVNHDCWPNCTVILNHGKIELRALGKIEPGEEVTVSYvdflNVTEDRQRqlkmhyfFDC 263
Cdd:COG2940   60 FELDDDGVIDGALGG--NPARFINHSCDPNCEADEEDGRIFIVALRDIAAGEELTYDY----GLDYDEEE-------YPC 126


                 ....*...
gi 197631975 264 TCEHCKGH 271
Cdd:COG2940  127 RCPNCRGT 134
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 205-241 1.25e-08

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 52.14  E-value: 1.25e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 197631975  205 LVNHDCWPNCTVIL----NHGKIELRALGKIEPGEEVTVSY 241
Cdd:pfam00856  74 FINHSCDPNCEVRVvyvnGGPRIVIFALRDIKPGEELTIDY 114
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 160-246 1.27e-08

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 52.34  E-value: 1.27e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975   160 WPRNSKQHRVDDISHiFGVINCNGFTVSDQRGLnavgvglFPNLCLVNHDCWPNCTVIL----NHGKIELRALGKIEPGE 235
Cdd:smart00317  40 AEERPKAYDTDGAKA-FYLFDIDSDLCIDARRK-------GNLARFINHSCEPNCELLFvevnGDDRIVIFALRDIKPGE 111

                           90
                   ....*....|.
gi 197631975   236 EVTVSYVDFLN 246
Cdd:smart00317 112 ELTIDYGSDYA 122
 
Name Accession Description Interval E-value
SET_SMYD1 cd10526
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 ...
 3-269 6.25e-125

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 (SMYD1) and similar proteins; SMYD1 (EC 2.1.1.43), also termed BOP, is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD1 plays a critical role in cardiomyocyte differentiation, cardiac morphogenesis and myofibril organization, as well as in the regulation of endothelial cells (ECs). It is expressed in vascular endothelial cells, it has beenshown that knockdown of SMYD1 in endothelial cells impairs EC migration and tube formation.


Pssm-ID: 380924 [Multi-domain]  Cd Length: 210  Bit Score: 355.18  E-value: 6.25e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975   3 NVEVFDSPGKGRGLRATKELLSGDVLFSEPPFAAVVFdsladkichscfrrqdklqrcgqckfaqycdktcqsagwkehk 82
Cdd:cd10526    2 GVEVFTSEGKGRGLKATKEFWAGDVIFAEPPYAAVVF------------------------------------------- 38

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975  83 lecgaikafgaigdnfGKAPNENIRLAARIMWRLDKEGGVMSDMQMTSLDDLENHISDMPEDDLKELKVDIHNFLDYWPR 162
Cdd:cd10526   39 ----------------GKAPNENIRLAARILWRIEREGGGLKEGELVSIEDLQDHLEDFSEEEKKDLREDVHSFLDYWPY 102

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975 163 NSKQHRVDDISHIFGVINCNGFTVSDQRGLNAVGVGLFPNLCLVNHDCWPNCTVILNHGKIELRALGKIEPGEEVTVSYV 242
Cdd:cd10526  103 QSQQFSMEYISHIFGVINCNGFTLSDQRGLQAVGVGIFPNLCLVNHDCWPNCTVIFNNGRIELRALGKISEGDELTVSYI 182

                        250       260
                 ....*....|....*....|....*..
gi 197631975 243 DFLNVTEDRQRQLKMHYFFDCTCEHCK 269
Cdd:cd10526  183 DFLNTSEDRKEQLKKQYYFDCTCEHCT 209
SET_SMYD1_2_3-like cd19167
SET domain (including post-SET domain) found in SET and MYND domain-containing proteins, SMYD1, ...
 3-268 3.25e-78

SET domain (including post-SET domain) found in SET and MYND domain-containing proteins, SMYD1, SMYD2, SMYD3 and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1, SMYD2 and SMYD3. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex.


Pssm-ID: 380944 [Multi-domain]  Cd Length: 205  Bit Score: 236.55  E-value: 3.25e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975   3 NVEVFDSPGKGRGLRATKELLSGDVLFSEPPFAAVVFdsladkichscfrrqdklqrcgqckfaqycdktcqsagwkehk 82
Cdd:cd19167    2 QVERFCSPGKGRGLRALKPFEPGDLIFSERPYAYVLT------------------------------------------- 38

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975  83 lecgaikafgaigdnfgkaPNENIRLAARIMWRLDKEGGVMSDmQMTSLDDLENHISDMPEDDLKELKVDIHNFLDYWPR 162
Cdd:cd19167   39 -------------------PPEHVRLTGRILYKQHIRKTRTSG-KLLSVYDLESHVEKLDEEKKDGLRSDVATLHQFMSK 98

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975 163 NSKQHRVDDISHIFGVINCNGFTVSDQrGLNAVGVGLFPNLCLVNHDCWPNCTVILNHGKIELRALGKIEPGEEVTVSYV 242
Cdd:cd19167   99 DLQLPDAAYLVELFGKVNCNGFTISDE-ELQHVGVGIYPQAALLNHSCCPNCIVTFNGPNIEVRAVQEIEPGEEVFHSYI 177

                        250       260
                 ....*....|....*....|....*.
gi 197631975 243 DFLNVTEDRQRQLKMHYFFDCTCEHC 268
Cdd:cd19167  178 DLLYPTEERRDQLRDQYFFLCQCADC 203
SET_SMYD3 cd19203
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 ...
 2-269 4.87e-51

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 (SMYD3) and similar proteins; SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. It is overexpressed in colorectal, breast, prostate, and hepatocellular tumors, and has been implicated as an oncogene in human malignancies. Methylation of MEKK2 by SMYD3 is important for regulation of the MEK/ERK pathway, suggesting the possibility of selectively targeting SMYD3 in RAS-driven cancers.


Pssm-ID: 380980 [Multi-domain]  Cd Length: 210  Bit Score: 167.16  E-value: 4.87e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975   2 DNVEVFDSPGKGRGLRATKELLSGDVLFSEPPFAAVVfdsladkichscfrrqdklqrcgqckfaqycdktcqSAGWKEH 81
Cdd:cd19203    1 SKVEKFETAEKGRGLRAVTPLKPGELVLKADPFAYTV------------------------------------CNPPDSV 44

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975  82 KLECGAIKAFgaigdnFGKAPNENIRLaarimwrldkeggvmsdmqmTSLDDLENHISDMPEDDLKELK----VDIHNFL 157
Cdd:cd19203   45 RLEGRIIFKL------LDKAPSESEKL--------------------YSFYDLQSNINKLSEDRKEGLRqlamVLQHYLR 98

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975 158 DYWPRNSKQHRVDDISHIFGVINCNGFTVSDQRgLNAVGVGLFPNLCLVNHDCWPNCTVILNHGKIELRALGKIEPGEEV 237
Cdd:cd19203   99 EEIQDASQLPPAFDIFELFAKVTCNSFTICDAE-MQEVGVGLYPSASLLNHSCDPNCVIVFNGPHLLLRAIREIEVGEEL 177

                        250       260       270
                 ....*....|....*....|....*....|..
gi 197631975 238 TVSYVDFLNVTEDRQRQLKMHYFFDCTCEHCK 269
Cdd:cd19203  178 TISYIDMLMPSEERRKQLRDQYCFECDCFRCQ 209
SET_SMYD2 cd19202
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 ...
 2-268 2.65e-37

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 (SMYD2) and similar proteins; SMYD2 (also termed HSKM-B, lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). It plays a role in myofilament organization in both skeletal and cardiac muscles via Hsp90 methylation. SMYD2 overexpression is associated with tumor cell proliferation and a worse outcome in human papillomavirus-unrelated nonmultiple head and neck carcinomas. It regulates leukemia cell growth such that diminished SMYD2 expression upregulates SET7/9, thereby possibly shifting leukemia cells from growth to quiescence state associated with resistance to DNA damage associated with Acute Myeloid Leukemia (AML).


Pssm-ID: 380979 [Multi-domain]  Cd Length: 206  Bit Score: 131.87  E-value: 2.65e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975   2 DNVEVFDSPGKGRGLRATKELLSGDVLFSEPPFAAVVfdsladkichscfrrqdklqrcgqckfaqycdktcqsagwkeh 81
Cdd:cd19202    1 GGLERFCSPGKGRGLRALRPFQVGDLLFSCPAYAYVL------------------------------------------- 37

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975  82 klecgaikafgaigdnfgkAPNENIRLAARIMWRLDKEGGVMSDMQMTSLDDLENHISDMPEDDLKELKVDIHNFLDYWP 161
Cdd:cd19202   38 -------------------TPSETVRLTARILAKQKIHPERTPSEKLLAVKEFESHLDKLDNEKKDLIQSDIAALHHFYS 98

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975 162 RNSKQHRVDDISHIFGVINCNGFTVSDQRgLNAVGVGLFPNLCLVNHDCWPNCTVILNHGKIELRALGKIEPGEEVTVSY 241
Cdd:cd19202   99 KHLEFPDNDSLVVLFAQVNCNGFTIEDEE-LSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSY 177

                        250       260
                 ....*....|....*....|....*..
gi 197631975 242 VDFLNVTEDRQRQLKMHYFFDCTCEHC 268
Cdd:cd19202  178 IDLLYPTEDRNDRLRDSYFFTCECQEC 204
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 182-268 2.14e-28

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 105.92  E-value: 2.14e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975 182 NGFTVSDqrGLNAVGVGLFPNLCLVNHDCWPNCTVILNH-GKIELRALGKIEPGEEVTVSYVDFLNVTEDRQRQLKMHYF 260
Cdd:cd20071   37 NSFSLTD--GLNEIGVGLFPLASLLNHSCDPNAVVVFDGnGTLRVRALRDIKAGEELTISYIDPLLPRTERRRELLEKYG 114


                 ....*...
gi 197631975 261 FDCTCEHC 268
Cdd:cd20071  115 FTCSCPRC 122
SET_SMYD4 cd10536
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 2-268 5.17e-23

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.


Pssm-ID: 380934 [Multi-domain]  Cd Length: 218  Bit Score: 94.29  E-value: 5.17e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975   2 DNVEVFDSPGKGRGLRATKELLSGDVLFSEPPFAAVV------FDSLADKICHSCFRRQDKLQRCGqckfaqycdktcqs 75
Cdd:cd10536    6 SAVSLRYSEEKGRFLVATRDIKAGEVLIVEKPYASVLlpyssdYRSVYNLVTHTENRSPEDLFQRA-------------- 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975  76 agwkehkLECGAIKAFgaigdnfgkapnenirlaarimwrLDKEGGVMSDMQMTSLDDLEnhisdmPEDDLKELkvdihn 155
Cdd:cd10536   72 -------LTAVFLAKC------------------------LQLSGYFLLWEASTELNGEE------PESILGGL------ 108

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975 156 fldywprnskqhrvddISHIFGVINCNGFTVSDQRGLNA-----------VGVGLFPNLCLVNHDCWPNCTVILNHGKIE 224
Cdd:cd10536  109 ----------------LLRHLQQLQCNAHAITELQTTSSgsqvdtskqvrIATAIYPTLSLLNHSCDPNTIRSFYGNTIV 172

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 197631975 225 LRALGKIEPGEEVTVSY-VDFLNVT-EDRQRQLKMHYFFDCTCEHC 268
Cdd:cd10536  173 VRATRPIKKGEEITICYgPHFSRMKrSERQRLLKEQYFFDCSCEAC 218
zf-MYND pfam01753
MYND finger;
47-85 4.12e-14

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 65.13  E-value: 4.12e-14
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 197631975   47 CHSCFRRQDKLQRCGQCKFAQYCDKTCQSAGWKEHKLEC 85
Cdd:pfam01753   1 CAVCGKEALKLLRCSRCKSVYYCSKECQKADWPYHKKEC 39
SET_SMYD5 cd10521
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 3-268 3.05e-13

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 5 (SMYD5) and similar proteins; SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions. It plays an important role in chromosome integrity by regulating heterochromatin and repressing endogenous repetitive DNA elements during differentiation. In zebrafish embryogenesis, it plays pivotal roles in both primitive and definitive hematopoiesis.


Pssm-ID: 380919 [Multi-domain]  Cd Length: 282  Bit Score: 68.49  E-value: 3.05e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975   3 NVEV-FDSPGKGRGLRATKELLSGDVLFSEPPFAAVVF--------DSLAD------------------KICHSCFRRQD 55
Cdd:cd10521    1 HVEVrFIDAAKGRGLFATRDFKKGDIIFEEKPLVCAQFlwnelhplNKLQEawrnmhyppetasimliaRMIATVKQAKD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975  56 KLQRCGQckFAQYCDKTCQSAGWKEHKLecgaikafgaIGDNFgKAPNENIRLA-------ARIMWRLDKEG-------- 120
Cdd:cd10521   81 KDEWLKL--FSQFCSATANEEEHIAHKL----------LGKQF-QGQLELLRQLftealyeERLSQWFTPEGfrslfalv 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975 121 -----GVMS---DMQMTSLDDLEnhisdMPEDDLKELKVDIHNFLDywprnskqhRVDDISHIFgvincngftvsdqrgL 192
Cdd:cd10521  148 gtngqGIGTsslSVWVHNCDALE-----LPEQEREELDAFIDQLYV---------DIEKESGEF---------------L 198

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975 193 NAVGVGLFPNLCLVNHDCWPNCTVILNHGK--IELRALGKIEPGEEVTVSYVDFLNVTED---RQRQLKMHYFFDCTCEH 267
Cdd:cd10521  199 NCEGSGLYLLQSCCNHSCVPNAEITFPENNftLSLKALRDIQEGEEICISYLDECQRERSrhsRQKILRENYLFICNCPK 278


                 .
gi 197631975 268 C 268
Cdd:cd10521  279 C 279
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
184-271 9.80e-10

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 55.74  E-value: 9.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975 184 FTVSDQRGLNAVGVGlfPNLCLVNHDCWPNCTVILNHGKIELRALGKIEPGEEVTVSYvdflNVTEDRQRqlkmhyfFDC 263
Cdd:COG2940   60 FELDDDGVIDGALGG--NPARFINHSCDPNCEADEEDGRIFIVALRDIAAGEELTYDY----GLDYDEEE-------YPC 126


                 ....*...
gi 197631975 264 TCEHCKGH 271
Cdd:COG2940  127 RCPNCRGT 134
SET_Suv4-20-like cd10524
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...
 205-269 8.49e-09

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation. The family also includes Suv4-20 homologs, lysine N-methyltransferase 5B (KMT5B) and lysine N-methyltransferase 5C (KMT5C). Both KMT5B (also termed lysine-specific methyltransferase 5B, or suppressor of variegation 4-20 homolog 1, or Su(var)4-20 homolog 1, or Suv4-20h1) and KMT5C (also termed lysine-specific methyltransferase 5C, or suppressor of variegation 4-20 homolog 2, or Su(var)4-20 homolog 2, or Suv4-20h2) are histone methyltransferases that specifically trimethylate 'Lys-20' of histone H4 (H4K20me3). They play central roles in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380922 [Multi-domain]  Cd Length: 141  Bit Score: 53.44  E-value: 8.49e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 197631975 205 LVNHDCWPNCtVILNHGK--IELRALGKIEPGEEVTVSYVDflnvtedrqrqlkmHYFF----DCTCEHCK 269
Cdd:cd10524   79 FINHDCRPNC-KFVPTGKstACVKVLRDIEPGEEITVYYGD--------------NYFGenneECECETCE 134
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 205-241 1.25e-08

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 52.14  E-value: 1.25e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 197631975  205 LVNHDCWPNCTVIL----NHGKIELRALGKIEPGEEVTVSY 241
Cdd:pfam00856  74 FINHSCDPNCEVRVvyvnGGPRIVIFALRDIKPGEELTIDY 114
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 160-246 1.27e-08

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 52.34  E-value: 1.27e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975   160 WPRNSKQHRVDDISHiFGVINCNGFTVSDQRGLnavgvglFPNLCLVNHDCWPNCTVIL----NHGKIELRALGKIEPGE 235
Cdd:smart00317  40 AEERPKAYDTDGAKA-FYLFDIDSDLCIDARRK-------GNLARFINHSCEPNCELLFvevnGDDRIVIFALRDIKPGE 111

                           90
                   ....*....|.
gi 197631975   236 EVTVSYVDFLN 246
Cdd:smart00317 112 ELTIDYGSDYA 122
SET_LSMT cd10527
SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; ...
 3-241 2.25e-06

SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; Rubisco LSMT is a non-histone protein methyl transferase responsible for the trimethylation of lysine14 in the large subunit of Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase). The family also includes SET domain-containing proteins, SETD3, SETD4 and SETD6, which belong to methyltransferase class VII that represents classical non-histone SET domain methyltransferases. Members in this family contain a SET domain and a C-terminal RubisCO LSMT substrate-binding (Rubis-subs-bind) domain.


Pssm-ID: 380925 [Multi-domain]  Cd Length: 236  Bit Score: 47.83  E-value: 2.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975   3 NVEVFDSPGKGRGLRATKELLSGDVLFSEPPfaavvfdsladkicHSCFRRqDKLQRCGQCKFAQYCDKTCQSAGWKEhk 82
Cdd:cd10527    1 GVELAESPDGGRGLFATRDIAAGEVLLSVPR--------------SLLLTV-ETARESPLGGAALALLELDPELSWDV-- 63

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975  83 lecgaikafgaigdnfgkapneniRLAARIMWrlDKEGGVMSDMQ--MTSL-DDLENHISDMPEDDLKELKV-------- 151
Cdd:cd10527   64 ------------------------ALALFLLY--ERARGPDSFWApyLDSLpRPFEDTPLFWSEEELDALQGtplleaaa 117

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975 152 -----------DIHNFLDYWPRNSKQHRV--DDISHIFGVINCNGFTVSDQRGlnAVGVGLFPNLCLVNHDCW-PNCTVI 217
Cdd:cd10527  118 aqrrrlreeyeALVEALPEALPAEPGEAFtlEEFLWALALVLSRAFSLPVPDG--GGGLALVPLADMLNHSPDaPNVRYE 195

                        250       260
                 ....*....|....*....|....*.
gi 197631975 218 LNHGK--IELRALGKIEPGEEVTVSY 241
Cdd:cd10527  196 YDEDEgsFVLVATRDIAAGEEVFISY 221
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 206-241 1.24e-05

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 42.62  E-value: 1.24e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 197631975 206 VNHDCWPNCTVIL----NHGKIELRALGKIEPGEEVTVSY 241
Cdd:cd08161   32 INHSCEPNCEFEEvyvgGKPRVFIVALRDIKAGEELTVDY 71
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 205-272 6.76e-05

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 41.89  E-value: 6.76e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 197631975 205 LVNHDCWPNCTV---ILN-HGKIELRALGKIEPGEEVTVSYvDFLNVTEDRQRQLKmhyffdCTCEHCKGHI 272
Cdd:cd19174   75 FVNHSCDPNCEMqkwSVNgVYRIGLFALKDIPAGEELTYDY-NFHSFNVEKQQPCK------CGSPNCRGVI 139
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
 184-241 1.09e-04

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


Pssm-ID: 380938  Cd Length: 112  Bit Score: 40.70  E-value: 1.09e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 197631975 184 FTVSDQRGLNAVGVGlfpnlCLVNHDCWPNCTVILNHGK--IELRALGKIEPGEEVTVSY 241
Cdd:cd10540   52 FSWGDGCLALALGYG-----SMFNHSYTPNAEYEIDFENqtIVFYALRDIEAGEELTINY 106
SET_KMT5C cd19185
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5C (KMT5C) ...
 205-241 1.74e-04

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5C (KMT5C) and similar proteins; KMT5C (also termed lysine N-methyltransferase 5C, lysine-specific methyltransferase 5C, suppressor of variegation 4-20 homolog 2, Su(var)4-20 homolog 2 or Suv4-20h2) is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 (H4K20me3). It plays a central role in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380962  Cd Length: 142  Bit Score: 40.79  E-value: 1.74e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 197631975 205 LVNHDCWPNCTVILNHG-KIELRALGKIEPGEEVTVSY 241
Cdd:cd19185   79 FINHDCKPNCKFVPADGnAACVKVLRDIEPGDEVTCFY 116
SET_SETD1-like cd10518
SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), ...
 205-241 3.48e-03

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380916  Cd Length: 150  Bit Score: 37.19  E-value: 3.48e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 197631975 205 LVNHDCWPNC-TVILNHG---KIELRALGKIEPGEEVTVSY 241
Cdd:cd10518   90 FINHSCDPNCyAKIITVDgekHIVIFAKRDIAPGEELTYDY 130
SET_KMT2A_2B cd19170
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), ...
 206-241 3.70e-03

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins; This family includes KMT2A and KMT2B. Both KMT2A (also termed ALL-1 or CXXC7 or MLL or MLL1 or TRX1 or HRX) and KMT2B (also termed MLL4 or TRX2) act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380947 [Multi-domain]  Cd Length: 152  Bit Score: 37.37  E-value: 3.70e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 197631975 206 VNHDCWPNC----TVILNHGKIELRALGKIEPGEEVTVSY 241
Cdd:cd19170   90 INHSCEPNCysrvVNIDGKKHIVIFALRRILRGEELTYDY 129
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 202-241 5.42e-03

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 36.17  E-value: 5.42e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 197631975 202 NLC-LVNHDCWPNCTVILNHGK----IELRALGKIEPGEEVTVSY 241
Cdd:cd10522   72 NLTrFINHSDQPNLELIVRTLKgeqhIGFVAIRDIKPGEELFISY 116
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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