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Conserved domains on  [gi|19743850|ref|NP_598012|]
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decorin isoform c precursor [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12020562)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-158 7.31e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.27  E-value: 7.31e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743850  69 DLGLPPSLTELHLDGNKISRVDAaSLKGLNNLAKLGLSFNSISAVDNgSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQ 148
Cdd:COG4886 131 ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPEPLGNLTNLE 208

                        90
                ....*....|
gi 19743850 149 VVYLHNNNIS 158
Cdd:COG4886 209 ELDLSGNQLT 218
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 54-72 3.44e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


:

Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 39.53  E-value: 3.44e-05
                          10
                  ....*....|....*....
gi 19743850    54 CPFRCQCHLRVVQCSDLGL 72
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGL 20
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-158 7.31e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.27  E-value: 7.31e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743850  69 DLGLPPSLTELHLDGNKISRVDAaSLKGLNNLAKLGLSFNSISAVDNgSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQ 148
Cdd:COG4886 131 ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPEPLGNLTNLE 208

                        90
                ....*....|
gi 19743850 149 VVYLHNNNIS 158
Cdd:COG4886 209 ELDLSGNQLT 218
LRR_8 pfam13855
Leucine rich repeat;
74-134 1.85e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.85  E-value: 1.85e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19743850    74 PSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKL 134
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 75-160 7.15e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 7.15e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743850  75 SLTELHLDGNKISRVDAasLKGLNNLAKLGLSFNSISAVDNgsLANTPHLRELHLDNNKLTRVPgGLAEHKYIQVVYLHN 154
Cdd:cd21340   3 RITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGG 77


                ....*.
gi 19743850 155 NNISVV 160
Cdd:cd21340  78 NRISVV 83
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 54-72 3.44e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 39.53  E-value: 3.44e-05
                          10
                  ....*....|....*....
gi 19743850    54 CPFRCQCHLRVVQCSDLGL 72
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGL 20
LRRNT smart00013
Leucine rich repeat N-terminal domain;
54-76 3.66e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 39.61  E-value: 3.66e-05
                           10        20
                   ....*....|....*....|....*.
gi 19743850     54 CPFRCQCHLRVVQCSDLGL---PPSL 76
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLtevPLDL 27
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 61-158 2.00e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 2.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743850   61 HLRVVQCSDLG-LPPS---LTELH---LDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNK 133
Cdd:PLN00113 240 HLDLVYNNLTGpIPSSlgnLKNLQylfLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNN 319

                         90       100
                 ....*....|....*....|....*.
gi 19743850  134 LT-RVPGGLAEHKYIQVVYLHNNNIS 158
Cdd:PLN00113 320 FTgKIPVALTSLPRLQVLQLWSNKFS 345
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-158 7.31e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.27  E-value: 7.31e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743850  69 DLGLPPSLTELHLDGNKISRVDAaSLKGLNNLAKLGLSFNSISAVDNgSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQ 148
Cdd:COG4886 131 ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPEPLGNLTNLE 208

                        90
                ....*....|
gi 19743850 149 VVYLHNNNIS 158
Cdd:COG4886 209 ELDLSGNQLT 218
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
74-158 3.02e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 70.35  E-value: 3.02e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743850  74 PSLTELHLDGNKISRVDAaSLKGLNNLAKLGLSFNSISAVDNgSLANTPHLRELHLDNNKLTRVPGGLAEHKYIQVVYLH 153
Cdd:COG4886 159 TNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLS 236


                ....*
gi 19743850 154 NNNIS 158
Cdd:COG4886 237 NNQLT 241
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-158 1.96e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.04  E-value: 1.96e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743850  68 SDLGLPPSLTELHLDGNKISRVDaASLKGLNNLAKLGLSFNSISAVDngSLANTPHLRELHLDNNKLTRVPgGLAEHKYI 147
Cdd:COG4886 199 EPLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLP-PLANLTNL 274

                        90
                ....*....|.
gi 19743850 148 QVVYLHNNNIS 158
Cdd:COG4886 275 KTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
61-158 3.41e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 67.65  E-value: 3.41e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743850  61 HLRVVQCSDLGLPPSLTELHLDGNKISRVDaASLKGLNNLAKLGLSFNSISAVDNgSLANTPHLRELHLDNNKLTRVPGG 140
Cdd:COG4886 100 ELDLSGNEELSNLTNLESLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE 177

                        90
                ....*....|....*...
gi 19743850 141 LAEHKYIQVVYLHNNNIS 158
Cdd:COG4886 178 LGNLTNLKELDLSNNQIT 195
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
74-163 1.20e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.73  E-value: 1.20e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743850  74 PSLTELHLDGNKISRVdAASLKGLNNLAKLGLSFNSISAVDNgSLANTPHLRELHLDNNKLTRVPgGLAEHKYIQVVYLH 153
Cdd:COG4886 182 TNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLS 258

                        90
                ....*....|
gi 19743850 154 NNNISVVGSS 163
Cdd:COG4886 259 NNQLTDLPPL 268
LRR_8 pfam13855
Leucine rich repeat;
74-134 1.85e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.85  E-value: 1.85e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19743850    74 PSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKL 134
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
68-163 2.12e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.18  E-value: 2.12e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743850  68 SDLGLPPSLTELHLDGNKisrvdaaSLKGLNNLAKLGLSFNSISAVDNgSLANTPHLRELHLDNNKLTRVPGGLAEHKYI 147
Cdd:COG4886  90 TDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEPLGNLTNL 161

                        90
                ....*....|....*.
gi 19743850 148 QVVYLHNNNISVVGSS 163
Cdd:COG4886 162 KSLDLSNNQLTDLPEE 177
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 75-160 7.15e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 7.15e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743850  75 SLTELHLDGNKISRVDAasLKGLNNLAKLGLSFNSISAVDNgsLANTPHLRELHLDNNKLTRVPgGLAEHKYIQVVYLHN 154
Cdd:cd21340   3 RITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGG 77


                ....*.
gi 19743850 155 NNISVV 160
Cdd:cd21340  78 NRISVV 83
LRR_8 pfam13855
Leucine rich repeat;
99-157 1.55e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 1.55e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743850    99 NLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLAEH-KYIQVVYLHNNNI 157
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 69-139 1.74e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.09  E-value: 1.74e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19743850  69 DLGLPPSLTELHLDGNKISRVDaaSLKGLNNLAKLGLSFNSISAVDNgsLANTPHLRELHLDNNKLTRVPG 139
Cdd:cd21340  19 NLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVEG 85
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 61-167 5.44e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.81  E-value: 5.44e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743850  61 HLRVVQCSDLGLPPSLTELHLDGNKISRVDAASLKGL----NNLAKLGLSFNSISavDNG------SLANTPHLRELHLD 130
Cdd:cd00116 124 GLRLLAKGLKDLPPALEKLVLGRNRLEGASCEALAKAlranRDLKELNLANNGIG--DAGiralaeGLKANCNLEVLDLN 201

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 19743850 131 NNKLTR-----VPGGLAEHKYIQVVYLHNNNISVVGSSDFCP 167
Cdd:cd00116 202 NNGLTDegasaLAETLASLKSLEVLNLGDNNLTDAGAAALAS 243
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 54-72 3.44e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 39.53  E-value: 3.44e-05
                          10
                  ....*....|....*....
gi 19743850    54 CPFRCQCHLRVVQCSDLGL 72
Cdd:pfam01462   2 CPVPCHCSATVVNCSDRGL 20
LRRNT smart00013
Leucine rich repeat N-terminal domain;
54-76 3.66e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 39.61  E-value: 3.66e-05
                           10        20
                   ....*....|....*....|....*.
gi 19743850     54 CPFRCQCHLRVVQCSDLGL---PPSL 76
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLtevPLDL 27
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 68-138 4.01e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.85  E-value: 4.01e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19743850  68 SDLGLPPSLTELHLDGNKISrvDAASLKGLNNLAKLGLSFNSISAVDN--GSLANTPHLRELHLDNNKLTRVP 138
Cdd:cd21340 114 SLAALSNSLRVLNISGNNID--SLEPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 56-135 8.72e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.34  E-value: 8.72e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743850  56 FRCQCHLRVVQCSDLGL--------------PPSLTELHLDGNKISRVDAASL-----KGLNNLAKLGLSFNSISAVDNG 116
Cdd:cd00116 189 LKANCNLEVLDLNNNGLtdegasalaetlasLKSLEVLNLGDNNLTDAGAAALasallSPNISLLTLSLSCNDITDDGAK 268

                        90       100
                ....*....|....*....|...
gi 19743850 117 SLA----NTPHLRELHLDNNKLT 135
Cdd:cd00116 269 DLAevlaEKESLLELDLRGNKFG 291
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 61-158 2.00e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 2.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743850   61 HLRVVQCSDLG-LPPS---LTELH---LDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNK 133
Cdd:PLN00113 240 HLDLVYNNLTGpIPSSlgnLKNLQylfLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNN 319

                         90       100
                 ....*....|....*....|....*.
gi 19743850  134 LT-RVPGGLAEHKYIQVVYLHNNNIS 158
Cdd:PLN00113 320 FTgKIPVALTSLPRLQVLQLWSNKFS 345
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 74-158 4.63e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 4.63e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743850  74 PSLTELHLDGNKISRVdaaslKGLNNLAKL--------------GLSFNSISAVdngSLANTphLRELHLDNNKLTRVpG 139
Cdd:cd21340  68 VNLKKLYLGGNRISVV-----EGLENLTNLeelhienqrlppgeKLTFDPRSLA---ALSNS--LRVLNISGNNIDSL-E 136

                        90
                ....*....|....*....
gi 19743850 140 GLAEHKYIQVVYLHNNNIS 158
Cdd:cd21340 137 PLAPLRNLEQLDASNNQIS 155
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 74-165 6.21e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.22  E-value: 6.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743850   74 PSLTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKL-TRVPGGLAEHKYIQVVYL 152
Cdd:PLN00113 332 PRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLeGEIPKSLGACRSLRRVRL 411

                         90
                 ....*....|...
gi 19743850  153 HNNNISVVGSSDF 165
Cdd:PLN00113 412 QDNSFSGELPSEF 424
LRR_8 pfam13855
Leucine rich repeat;
122-165 1.49e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 1.49e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 19743850   122 PHLRELHLDNNKLTRVPGGLAEH-KYIQVVYLHNNNISVVGSSDF 165
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGlSNLKVLDLSNNLLTTLSPGAF 45
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
63-157 2.94e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 37.99  E-value: 2.94e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743850  63 RVVQCSDLGLPPSLTELHLDGNKISRVDaaSLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLTRVPGGLA 142
Cdd:COG4886 239 QLTDLPELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLIL 316

                        90
                ....*....|....*
gi 19743850 143 EHKYIQVVYLHNNNI 157
Cdd:COG4886 317 LLLLTTLLLLLLLLK 331
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 75-166 3.40e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 37.85  E-value: 3.40e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743850  75 SLTELHLDGNKISRVDAAS----LKGLNNLAKLGLSFNSISavDNG------SLANTPHLRELHLDNNKLTRVPG----- 139
Cdd:COG5238 265 TVETLYLSGNQIGAEGAIAlakaLQGNTTLTSLDLSVNRIG--DEGaialaeGLQGNKTLHTLNLAYNGIGAQGAialak 342

                        90       100
                ....*....|....*....|....*..
gi 19743850 140 GLAEHKYIQVVYLHNNNISVVGSSDFC 166
Cdd:COG5238 343 ALQENTTLHSLDLSDNQIGDEGAIALA 369
PLN03150 PLN03150
hypothetical protein; Provisional
 76-141 4.27e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 37.49  E-value: 4.27e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19743850   76 LTELHLDGNKISRVDAASLKGLNNLAKLGLSFNSISAVDNGSLANTPHLRELHLDNNKLT-RVPGGL 141
Cdd:PLN03150 444 LQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSgRVPAAL 510
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 59-164 5.91e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 36.95  E-value: 5.91e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19743850  59 QCHLRVVQCSDLG----LPPSLTELHLDGNKISRVDAA------SLKGLNNLAKLGLSFNSISAVDNGSLANT---PHLR 125
Cdd:cd00116  32 GNTLGEEAAKALAsalrPQPSLKELCLSLNETGRIPRGlqsllqGLTKGCGLQELDLSDNALGPDGCGVLESLlrsSSLQ 111

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 19743850 126 ELHLDNNKLTRVPG-----GLAEHKY-IQVVYLHNNNISVVGSSD 164
Cdd:cd00116 112 ELKLNNNGLGDRGLrllakGLKDLPPaLEKLVLGRNRLEGASCEA 156
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 99-139 9.79e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 32.99  E-value: 9.79e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 19743850    99 NLAKLGLSFNSISAVDNgsLANTPHLRELHL-DNNKLTRVPG 139
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLsGNNKITDLSD 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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