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Conserved domains on  [gi|1974299617|ref|XP_039181763|]
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protocadherin alpha-5-like [Crotalus tigris]

Protein Classification

Cadherin_2 and Cadherin_repeat domain-containing protein( domain architecture ID 11175880)

protein containing domains Cadherin_2, Cadherin_repeat, and Cadherin_C_2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 29-111 2.20e-36

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 131.50  E-value: 2.20e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617  29 QLHYSVLEESQHGTFVGRIAQDLGLEVSELVPRMFRMLPKGEKDYFEVNLQNGILFVNSRIDREELCAKTADCVLHLEVI 108
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 1974299617 109 VEK 111
Cdd:pfam08266  81 LEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-346 3.35e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.19  E-value: 3.35e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617 246 IYKVKLLENAAVGTLVIKVNATDLDEGMNKEIYYSFTNHVPLNFqkiFSINSNTGEVIVEGGVDFEDLATYDLQIEAEDK 325
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL---FSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 1974299617 326 GFPPLSGHCQLIIEVLDINDN 346
Cdd:cd11304    78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 460-559 3.45e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 3.45e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617 460 SYTVFVKENNPPGAHIFTVSALDPDVAENALITYWIDEKlwPLSSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAG 539
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG--NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                          90       100
                  ....*....|....*....|
gi 1974299617 540 MPSLCGNATVQVFVLDENDN 559
Cdd:cd11304    79 GPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 157-240 4.27e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 96.65  E-value: 4.27e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617  157 ASDADIGTNALLTYKLS---LNEYFIVEQKTDEkfnkplaIVLKKPLDREESPVHHLVLTATDGGEPKLTGTVQLVINVL 233
Cdd:smart00112   2 ATDADSGENGKVTYSILsgnDDGLFSIDPETGE-------ITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*..
gi 1974299617  234 DVNDNPP 240
Cdd:smart00112  75 DVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 357-452 7.48e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 87.75  E-value: 7.48e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617 357 VPVLEDSPLGTVVALISVADRDSGDNGQIHCLLWPPSV--PFQLVSNfknYYSLVVAESLDREQVAEYQLMVKTEDQGIP 434
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDPS---TGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 1974299617 435 SLSASSILILPISDINDN 452
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 580-672 2.42e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.35  E-value: 2.42e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617 580 PGHIVGKIHALDADSGYNAWLRYELLEESSGPW-SVGQYSGEVSTKYPLDeSEGGKIQSVLVLMKDHGKPQLSATATLSV 658
Cdd:cd11304    12 PGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLfSIDPSTGEITTAKPLD-REEQSSYTLTVTATDGGGPPLSSTATVTI 90

                          90
                  ....*....|....
gi 1974299617 659 SLvtsgqtikTDIN 672
Cdd:cd11304    91 TV--------LDVN 96
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 686-764 1.17e-05

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


:

Pssm-ID: 465139  Cd Length: 84  Bit Score: 44.05  E-value: 1.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617 686 SINIYLIIAICSVSSLFLLATLIYVALRCHCKAK------ESMVYGPGMATLVCASEVGSWSYSNRHSHILAGVSaeagA 759
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSsallqsSGNLCSVPAPHFPGNDGTGTLPQSYSYEVCLTSDS----G 76


                  ....*
gi 1974299617 760 KSDLM 764
Cdd:pfam16492  77 KSEFK 81
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 29-111 2.20e-36

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 131.50  E-value: 2.20e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617  29 QLHYSVLEESQHGTFVGRIAQDLGLEVSELVPRMFRMLPKGEKDYFEVNLQNGILFVNSRIDREELCAKTADCVLHLEVI 108
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 1974299617 109 VEK 111
Cdd:pfam08266  81 LEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-346 3.35e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.19  E-value: 3.35e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617 246 IYKVKLLENAAVGTLVIKVNATDLDEGMNKEIYYSFTNHVPLNFqkiFSINSNTGEVIVEGGVDFEDLATYDLQIEAEDK 325
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL---FSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 1974299617 326 GFPPLSGHCQLIIEVLDINDN 346
Cdd:cd11304    78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 460-559 3.45e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 3.45e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617 460 SYTVFVKENNPPGAHIFTVSALDPDVAENALITYWIDEKlwPLSSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAG 539
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG--NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                          90       100
                  ....*....|....*....|
gi 1974299617 540 MPSLCGNATVQVFVLDENDN 559
Cdd:cd11304    79 GPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 157-240 4.27e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 96.65  E-value: 4.27e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617  157 ASDADIGTNALLTYKLS---LNEYFIVEQKTDEkfnkplaIVLKKPLDREESPVHHLVLTATDGGEPKLTGTVQLVINVL 233
Cdd:smart00112   2 ATDADSGENGKVTYSILsgnDDGLFSIDPETGE-------ITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*..
gi 1974299617  234 DVNDNPP 240
Cdd:smart00112  75 DVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-348 1.31e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.11  E-value: 1.31e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617  265 NATDLDEGMNKEIYYSFtnhVPLNFQKIFSINSNTGEVIVEGGVDFEDLATYDLQIEAEDKGFPPLSGHCQLIIEVLDIN 344
Cdd:smart00112   1 SATDADSGENGKVTYSI---LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 1974299617  345 DNEP 348
Cdd:smart00112  78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 157-238 1.17e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 1.17e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617 157 ASDADIGTNALLTYKLS---LNEYFIVEQKTDEkfnkplaIVLKKPLDREESPVHHLVLTATDGGEPKLTGTVQLVINVL 233
Cdd:cd11304    21 ATDPDSGENGEVTYSIVsgnEDGLFSIDPSTGE-------ITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVL 93


                  ....*
gi 1974299617 234 DVNDN 238
Cdd:cd11304    94 DVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 357-452 7.48e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 87.75  E-value: 7.48e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617 357 VPVLEDSPLGTVVALISVADRDSGDNGQIHCLLWPPSV--PFQLVSNfknYYSLVVAESLDREQVAEYQLMVKTEDQGIP 434
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDPS---TGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 1974299617 435 SLSASSILILPISDINDN 452
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
247-341 2.93e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.82  E-value: 2.93e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617 247 YKVKLLENAAVGTLVIKVNATDLDEGMNKEIYYSFTNHVPLNfqkIFSINSNTGEVIVEGGVDFEDLATYDLQIEAEDKG 326
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGG---NFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 1974299617 327 FPPLSGHCQLIIEVL 341
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 479-561 4.08e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.09  E-value: 4.08e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617  479 SALDPDVAENALITYWIDEKlwPLSSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAGMPSLCGNATVQVFVLDEND 558
Cdd:smart00112   1 SATDADSGENGKVTYSILSG--NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                   ...
gi 1974299617  559 NAP 561
Cdd:smart00112  79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 580-672 2.42e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.35  E-value: 2.42e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617 580 PGHIVGKIHALDADSGYNAWLRYELLEESSGPW-SVGQYSGEVSTKYPLDeSEGGKIQSVLVLMKDHGKPQLSATATLSV 658
Cdd:cd11304    12 PGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLfSIDPSTGEITTAKPLD-REEQSSYTLTVTATDGGGPPLSSTATVTI 90

                          90
                  ....*....|....
gi 1974299617 659 SLvtsgqtikTDIN 672
Cdd:cd11304    91 TV--------LDVN 96
Cadherin pfam00028
Cadherin domain;
461-554 5.91e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.79  E-value: 5.91e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617 461 YTVFVKENNPPGAHIFTVSALDPDVAENALITYWIDEKlwPLSSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAGM 540
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG--GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                          90
                  ....*....|....
gi 1974299617 541 PSLCGNATVQVFVL 554
Cdd:pfam00028  79 PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 373-454 7.32e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.37  E-value: 7.32e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617  373 SVADRDSGDNGQIHCLLWPPSV--PFQLVSNFKnyySLVVAESLDREQVAEYQLMVKTEDQGIPSLSASSILILPISDIN 450
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDdgLFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 1974299617  451 DNAP 454
Cdd:smart00112  78 DNAP 81
Cadherin pfam00028
Cadherin domain;
156-233 2.30e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.17  E-value: 2.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617 156 GASDADIGTNALLTYKLSLNEY---FIVEQKTDEkfnkplaIVLKKPLDREESPVHHLVLTATDGGEPKLTGTVQLVINV 232
Cdd:pfam00028  19 TATDPDLGPNGRIFYSILGGGPggnFRIDPDTGD-------ISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91


                  .
gi 1974299617 233 L 233
Cdd:pfam00028  92 L 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 31-128 3.71e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.40  E-value: 3.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617  31 HYSVLEESQHGTFVGRI-AQDLGLEVSELVprMFRMLPKGEKDYFEVNLQNGILFVNSRIDREELcaktadCVLHLEVIV 109
Cdd:cd11304     3 EVSVPENAPPGTVVLTVsATDPDSGENGEV--TYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQ------SSYTLTVTA 74

                          90       100
                  ....*....|....*....|....
gi 1974299617 110 E----KPLR-LFYVEVEIKDINDN 128
Cdd:cd11304    75 TdgggPPLSsTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
580-660 4.80e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 59.62  E-value: 4.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617 580 PGHIVGKIHALDADSGYNAWLRYELLE-ESSGPWSVGQYSGEVSTKYPLDESEGGKIqSVLVLMKDHGKPQLSATATLSV 658
Cdd:pfam00028  11 VGTEVLTVTATDPDLGPNGRIFYSILGgGPGGNFRIDPDTGDISTTKPLDRESIGEY-ELTVEATDSGGPPLSSTATVTI 89


                  ..
gi 1974299617 659 SL 660
Cdd:pfam00028  90 TV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 588-672 3.23e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.97  E-value: 3.23e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617  588 HALDADSGYNAWLRYELLEESSGPW-SVGQYSGEVSTKYPLDEsEGGKIQSVLVLMKDHGKPQLSATATLSVSLvtsgqt 666
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLfSIDPETGEITTTKPLDR-EEQPEYTLTVEATDGGGPPLSSTATVTITV------ 73


                   ....*.
gi 1974299617  667 ikTDIN 672
Cdd:smart00112  74 --LDVN 77
Cadherin pfam00028
Cadherin domain;
359-446 6.18e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.54  E-value: 6.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617 359 VLEDSPLGTVVALISVADRDSGDNGQIHCLLWPPSVPfqlvSNFK-NYYS--LVVAESLDREQVAEYQLMVKTEDQGIPS 435
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRiDPDTgdISTTKPLDRESIGEYELTVEATDSGGPP 80

                          90
                  ....*....|.
gi 1974299617 436 LSASSILILPI 446
Cdd:pfam00028  81 LSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 63-130 1.33e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.66  E-value: 1.33e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1974299617   63 FRMLPKGEKDYFEVNLQNGILFVNSRIDREELcaktadCVLHLEVIV----EKPLRLF-YVEVEIKDINDNAP 130
Cdd:smart00112  15 YSILSGNDDGLFSIDPETGEITTTKPLDREEQ------PEYTLTVEAtdggGPPLSSTaTVTITVLDVNDNAP 81
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 686-764 1.17e-05

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 44.05  E-value: 1.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617 686 SINIYLIIAICSVSSLFLLATLIYVALRCHCKAK------ESMVYGPGMATLVCASEVGSWSYSNRHSHILAGVSaeagA 759
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSsallqsSGNLCSVPAPHFPGNDGTGTLPQSYSYEVCLTSDS----G 76


                  ....*
gi 1974299617 760 KSDLM 764
Cdd:pfam16492  77 KSEFK 81
 
Name Accession Description Interval E-value
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 29-111 2.20e-36

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 131.50  E-value: 2.20e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617  29 QLHYSVLEESQHGTFVGRIAQDLGLEVSELVPRMFRMLPKGEKDYFEVNLQNGILFVNSRIDREELCAKTADCVLHLEVI 108
Cdd:pfam08266   1 QIRYSVPEETERGSFVGNLAKDLGLEVGELAARGARVVSKGNKQYFQLNPETGDLLLNEKLDREELCGSTEPCVLHFQVL 80


                  ...
gi 1974299617 109 VEK 111
Cdd:pfam08266  81 LEN 83
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 246-346 3.35e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 123.19  E-value: 3.35e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617 246 IYKVKLLENAAVGTLVIKVNATDLDEGMNKEIYYSFTNHVPLNFqkiFSINSNTGEVIVEGGVDFEDLATYDLQIEAEDK 325
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGL---FSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90       100
                  ....*....|....*....|.
gi 1974299617 326 GFPPLSGHCQLIIEVLDINDN 346
Cdd:cd11304    78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 460-559 3.45e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 105.86  E-value: 3.45e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617 460 SYTVFVKENNPPGAHIFTVSALDPDVAENALITYWIDEKlwPLSSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAG 539
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSG--NEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG 78

                          90       100
                  ....*....|....*....|
gi 1974299617 540 MPSLCGNATVQVFVLDENDN 559
Cdd:cd11304    79 GPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 157-240 4.27e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 96.65  E-value: 4.27e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617  157 ASDADIGTNALLTYKLS---LNEYFIVEQKTDEkfnkplaIVLKKPLDREESPVHHLVLTATDGGEPKLTGTVQLVINVL 233
Cdd:smart00112   2 ATDADSGENGKVTYSILsgnDDGLFSIDPETGE-------ITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*..
gi 1974299617  234 DVNDNPP 240
Cdd:smart00112  75 DVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 265-348 1.31e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.11  E-value: 1.31e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617  265 NATDLDEGMNKEIYYSFtnhVPLNFQKIFSINSNTGEVIVEGGVDFEDLATYDLQIEAEDKGFPPLSGHCQLIIEVLDIN 344
Cdd:smart00112   1 SATDADSGENGKVTYSI---LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 1974299617  345 DNEP 348
Cdd:smart00112  78 DNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 157-238 1.17e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.15  E-value: 1.17e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617 157 ASDADIGTNALLTYKLS---LNEYFIVEQKTDEkfnkplaIVLKKPLDREESPVHHLVLTATDGGEPKLTGTVQLVINVL 233
Cdd:cd11304    21 ATDPDSGENGEVTYSIVsgnEDGLFSIDPSTGE-------ITTAKPLDREEQSSYTLTVTATDGGGPPLSSTATVTITVL 93


                  ....*
gi 1974299617 234 DVNDN 238
Cdd:cd11304    94 DVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 357-452 7.48e-21

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 87.75  E-value: 7.48e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617 357 VPVLEDSPLGTVVALISVADRDSGDNGQIHCLLWPPSV--PFQLVSNfknYYSLVVAESLDREQVAEYQLMVKTEDQGIP 434
Cdd:cd11304     4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEdgLFSIDPS---TGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 1974299617 435 SLSASSILILPISDINDN 452
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
247-341 2.93e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.82  E-value: 2.93e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617 247 YKVKLLENAAVGTLVIKVNATDLDEGMNKEIYYSFTNHVPLNfqkIFSINSNTGEVIVEGGVDFEDLATYDLQIEAEDKG 326
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGG---NFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|....*
gi 1974299617 327 FPPLSGHCQLIIEVL 341
Cdd:pfam00028  78 GPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 479-561 4.08e-20

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 85.09  E-value: 4.08e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617  479 SALDPDVAENALITYWIDEKlwPLSSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAGMPSLCGNATVQVFVLDEND 558
Cdd:smart00112   1 SATDADSGENGKVTYSILSG--NDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                   ...
gi 1974299617  559 NAP 561
Cdd:smart00112  79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 580-672 2.42e-15

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 72.35  E-value: 2.42e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617 580 PGHIVGKIHALDADSGYNAWLRYELLEESSGPW-SVGQYSGEVSTKYPLDeSEGGKIQSVLVLMKDHGKPQLSATATLSV 658
Cdd:cd11304    12 PGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLfSIDPSTGEITTAKPLD-REEQSSYTLTVTATDGGGPPLSSTATVTI 90

                          90
                  ....*....|....
gi 1974299617 659 SLvtsgqtikTDIN 672
Cdd:cd11304    91 TV--------LDVN 96
Cadherin pfam00028
Cadherin domain;
461-554 5.91e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.79  E-value: 5.91e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617 461 YTVFVKENNPPGAHIFTVSALDPDVAENALITYWIDEKlwPLSSYISVHSESGKLYALQSLDYEELKLLEFQVRAKDAGM 540
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGG--GPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGG 78

                          90
                  ....*....|....
gi 1974299617 541 PSLCGNATVQVFVL 554
Cdd:pfam00028  79 PPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 373-454 7.32e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 67.37  E-value: 7.32e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617  373 SVADRDSGDNGQIHCLLWPPSV--PFQLVSNFKnyySLVVAESLDREQVAEYQLMVKTEDQGIPSLSASSILILPISDIN 450
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDdgLFSIDPETG---EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                   ....
gi 1974299617  451 DNAP 454
Cdd:smart00112  78 DNAP 81
Cadherin pfam00028
Cadherin domain;
156-233 2.30e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.17  E-value: 2.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617 156 GASDADIGTNALLTYKLSLNEY---FIVEQKTDEkfnkplaIVLKKPLDREESPVHHLVLTATDGGEPKLTGTVQLVINV 232
Cdd:pfam00028  19 TATDPDLGPNGRIFYSILGGGPggnFRIDPDTGD-------ISTTKPLDRESIGEYELTVEATDSGGPPLSSTATVTITV 91


                  .
gi 1974299617 233 L 233
Cdd:pfam00028  92 L 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 31-128 3.71e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 60.40  E-value: 3.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617  31 HYSVLEESQHGTFVGRI-AQDLGLEVSELVprMFRMLPKGEKDYFEVNLQNGILFVNSRIDREELcaktadCVLHLEVIV 109
Cdd:cd11304     3 EVSVPENAPPGTVVLTVsATDPDSGENGEV--TYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQ------SSYTLTVTA 74

                          90       100
                  ....*....|....*....|....
gi 1974299617 110 E----KPLR-LFYVEVEIKDINDN 128
Cdd:cd11304    75 TdgggPPLSsTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
580-660 4.80e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 59.62  E-value: 4.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617 580 PGHIVGKIHALDADSGYNAWLRYELLE-ESSGPWSVGQYSGEVSTKYPLDESEGGKIqSVLVLMKDHGKPQLSATATLSV 658
Cdd:pfam00028  11 VGTEVLTVTATDPDLGPNGRIFYSILGgGPGGNFRIDPDTGDISTTKPLDRESIGEY-ELTVEATDSGGPPLSSTATVTI 89


                  ..
gi 1974299617 659 SL 660
Cdd:pfam00028  90 TV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 588-672 3.23e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.97  E-value: 3.23e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617  588 HALDADSGYNAWLRYELLEESSGPW-SVGQYSGEVSTKYPLDEsEGGKIQSVLVLMKDHGKPQLSATATLSVSLvtsgqt 666
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLfSIDPETGEITTTKPLDR-EEQPEYTLTVEATDGGGPPLSSTATVTITV------ 73


                   ....*.
gi 1974299617  667 ikTDIN 672
Cdd:smart00112  74 --LDVN 77
Cadherin pfam00028
Cadherin domain;
359-446 6.18e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.54  E-value: 6.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617 359 VLEDSPLGTVVALISVADRDSGDNGQIHCLLWPPSVPfqlvSNFK-NYYS--LVVAESLDREQVAEYQLMVKTEDQGIPS 435
Cdd:pfam00028   5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPG----GNFRiDPDTgdISTTKPLDRESIGEYELTVEATDSGGPP 80

                          90
                  ....*....|.
gi 1974299617 436 LSASSILILPI 446
Cdd:pfam00028  81 LSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 63-130 1.33e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 49.66  E-value: 1.33e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1974299617   63 FRMLPKGEKDYFEVNLQNGILFVNSRIDREELcaktadCVLHLEVIV----EKPLRLF-YVEVEIKDINDNAP 130
Cdd:smart00112  15 YSILSGNDDGLFSIDPETGEITTTKPLDREEQ------PEYTLTVEAtdggGPPLSSTaTVTITVLDVNDNAP 81
Cadherin_C_2 pfam16492
Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some ...
 686-764 1.17e-05

Cadherin cytoplasmic C-terminal; Cadherin_C_2 is the cytoplasmic C-terminal domain of some proto-cadherins. It is this region of the cadherins that allows cell-adhesion and the essential feature of metazoan multicellularity. Cadherins are cell-surface receptors that function in cell adhesion, cell polarity, and tissue morphogenesis.


Pssm-ID: 465139  Cd Length: 84  Bit Score: 44.05  E-value: 1.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617 686 SINIYLIIAICSVSSLFLLATLIYVALRCHCKAK------ESMVYGPGMATLVCASEVGSWSYSNRHSHILAGVSaeagA 759
Cdd:pfam16492   1 DLTFYLVIALASVSFLFLLFVIVLIALRLRRWRSsallqsSGNLCSVPAPHFPGNDGTGTLPQSYSYEVCLTSDS----G 76


                  ....*
gi 1974299617 760 KSDLM 764
Cdd:pfam16492  77 KSEFK 81
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 32-128 1.54e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 44.26  E-value: 1.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1974299617  32 YSVLEESQHGTFVGRIAQDLGlevsELVPRMFRMLPKGEKD---YFEVNLQNGILFVNSRIDREELcaktadCVLHLEVI 108
Cdd:cd00031     4 GSAVEGRSRGSFRVSIPTDLI----ASSGEIIKISAAGKEAlpsWLHWEPHSGILEGLEKLDREDK------GVHYISVS 73

                          90       100
                  ....*....|....*....|....*
gi 1974299617 109 V-----EKPLRLFYVEVEIKDINDN 128
Cdd:cd00031    74 AaslgaNVPQTSSVFSIEVYDENDN 98
Cadherin pfam00028
Cadherin domain;
31-93 7.90e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 42.29  E-value: 7.90e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1974299617  31 HYSVLEESQHGTFVGRI-AQDLGLEVSELVprMFRMLPKGEKDYFEVNLQNGILFVNSRIDREE 93
Cdd:pfam00028   2 SASVPENAPVGTEVLTVtATDPDLGPNGRI--FYSILGGGPGGNFRIDPDTGDISTTKPLDRES 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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