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Conserved domains on  [gi|1964073316|dbj|BCR35259|]
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galactokinase [Mariniplasma anaerobium]

Protein Classification

galactokinase( domain architecture ID 1001803)

galactokinase catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

EC:  2.7.1.6
Gene Ontology:  GO:0004335|GO:0005524|GO:0006012
PubMed:  15526155
SCOP:  4001389

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05322 super family cl35305
galactokinase; Provisional
 1-383 3.45e-172

galactokinase; Provisional


The actual alignment was detected with superfamily member PRK05322:

Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 485.13  E-value: 3.45e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316   1 MKEKMNKQFAKLFNRNDGQVYYSPGRVNLIGEHIDYNGGFVFPCALSYGTYGIAAKRNDPKIKVFSNPF-SKEIYTFDLD 79
Cdd:PRK05322    2 MKEELKKKFAEVFGEEAEDVFFSPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSANFeDLGIIEFDLD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316  80 HLVKDSKNSWADYIKGSIKAILDKGYKIEYGIDLYIEGTLPVNAGLSSSSSLELLIIYIFDHLNSLNINRPEMAILGKDV 159
Cdd:PRK05322   82 DLSFDKEDDWANYPKGVLKFLQEAGYKIDHGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDLDRLELVKLGQKT 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 160 ENKFIGVNSGIMDQFIIANGQKDHAIMLNTETLEYQQIPLFLDTYSLLIVNTNKQRGLADSKYNERFQECQDSMAILQPK 239
Cdd:PRK05322  162 ENEFIGVNSGIMDQFAIGMGKKDHAILLDCNTLEYEYVPLDLGDYVIVIMNTNKRRELADSKYNERRAECEKALEELQKK 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 240 FGIKNLCSLSDEQLLLSKDMLSD-TIYRRTRHVQTEQKRTILSAKALKAGHIKEFADLMTSSHMSLKNDYEVTGVELDTL 318
Cdd:PRK05322  242 LDIKSLGELTEEEFDEYSYLIKDeTLLKRARHAVTENQRTLKAVKALKAGDLEKFGRLMNASHVSLRDDYEVTGLELDTL 321

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1964073316 319 VETLL-HSGATGARMTGAGFGGCVVALVETDKFDEVCKQTKAIYLDKIGYEPSFYNVVPEDGVSAI 383
Cdd:PRK05322  322 VEAAWkQEGVLGARMTGAGFGGCAIAIVKKDKVEAFKENVGKAYEEKIGYAASFYVAEIGDGAREL 387
 
Name Accession Description Interval E-value
PRK05322 PRK05322
galactokinase; Provisional
 1-383 3.45e-172

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 485.13  E-value: 3.45e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316   1 MKEKMNKQFAKLFNRNDGQVYYSPGRVNLIGEHIDYNGGFVFPCALSYGTYGIAAKRNDPKIKVFSNPF-SKEIYTFDLD 79
Cdd:PRK05322    2 MKEELKKKFAEVFGEEAEDVFFSPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSANFeDLGIIEFDLD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316  80 HLVKDSKNSWADYIKGSIKAILDKGYKIEYGIDLYIEGTLPVNAGLSSSSSLELLIIYIFDHLNSLNINRPEMAILGKDV 159
Cdd:PRK05322   82 DLSFDKEDDWANYPKGVLKFLQEAGYKIDHGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDLDRLELVKLGQKT 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 160 ENKFIGVNSGIMDQFIIANGQKDHAIMLNTETLEYQQIPLFLDTYSLLIVNTNKQRGLADSKYNERFQECQDSMAILQPK 239
Cdd:PRK05322  162 ENEFIGVNSGIMDQFAIGMGKKDHAILLDCNTLEYEYVPLDLGDYVIVIMNTNKRRELADSKYNERRAECEKALEELQKK 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 240 FGIKNLCSLSDEQLLLSKDMLSD-TIYRRTRHVQTEQKRTILSAKALKAGHIKEFADLMTSSHMSLKNDYEVTGVELDTL 318
Cdd:PRK05322  242 LDIKSLGELTEEEFDEYSYLIKDeTLLKRARHAVTENQRTLKAVKALKAGDLEKFGRLMNASHVSLRDDYEVTGLELDTL 321

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1964073316 319 VETLL-HSGATGARMTGAGFGGCVVALVETDKFDEVCKQTKAIYLDKIGYEPSFYNVVPEDGVSAI 383
Cdd:PRK05322  322 VEAAWkQEGVLGARMTGAGFGGCAIAIVKKDKVEAFKENVGKAYEEKIGYAASFYVAEIGDGAREL 387
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
1-383 1.62e-167

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 473.10  E-value: 1.62e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316   1 MKEKMNKQFAKLFNRNDGQVYYSPGRVNLIGEHIDYNGGFVFPCALSYGTYGIAAKRNDPKIKVFSNPFsKEIYTFDLDH 80
Cdd:COG0153     1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADF-DEEVEFDLDD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316  81 LVKDSKNSWADYIKGSIKAILDKGYKIEyGIDLYIEGTLPVNAGLSSSSSLELLIIYIFDHLNSLNINRPEMAILGKDVE 160
Cdd:COG0153    80 LEPGEEDGWANYVRGVAWALQERGYKLG-GFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIGQRAE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 161 NKFIGVNSGIMDQFIIANGQKDHAIMLNTETLEYQQIPLFLDTYSLLIVNTNKQRGLADSKYNERFQECQDSMAILqpkf 240
Cdd:COG0153   159 NEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPLEGYALVIVDTNVKHSLADSEYNERRAECEAAAAIL---- 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 241 GIKNLCSLSDEQLLLSKDMLSD-TIYRRTRHVQTEQKRTILSAKALKAGHIKEFADLMTSSHMSLKNDYEVTGVELDTLV 319
Cdd:COG0153   235 GVKSLRDVTLEDLEAARARLGDeVLRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPELDTLV 314

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1964073316 320 ETLL-HSGATGARMTGAGFGGCVVALVETDKFDEVCKQTKAIYLDKIGYEPSFYNVVPEDGVSAI 383
Cdd:COG0153   315 ELALaEAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTGLEPDFYVVKPSDGARRL 379
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 2-383 1.17e-101

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 305.98  E-value: 1.17e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316   2 KEKMNKQFAKLFNRNDGQVYYSPGRVNLIGEHIDYNGGFVFPCALSYGTYGIAAKRNDPKIKVFSNPFSKEIYTFDLDHL 81
Cdd:TIGR00131   1 CESIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNVRIYLANADNKFAERSLDLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316  82 VKDSKNS-WADYIKGSIKAILDKGYKIEYGIDLYIEGTLPVNAGLSSSSSLELLIIYIFDHLNSLNINRPEMAILGKDVE 160
Cdd:TIGR00131  81 LDGSEVSdWANYFKGVLHVAQERFNSFPLGADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHLPLDSKQILLRIQVAE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 161 NKFIGVNSGIMDQFIIANGQKDHAIMLNTETLEYQQIPLFLDTYSLLIVNTNKQRGLADSKYNERFQECQDSMAILQPKf 240
Cdd:TIGR00131 161 NHFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPQLGIAFVIANTNVKRTLAPSNYNTRRQECTTAANFLAAT- 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 241 GIKNLCSLSDEQL-----LLSKdmLSDTIYRRTRHVQTEQKRTILSAKALKAGHIKEFADLMTSSHMSLKNDYEVTGVEL 315
Cdd:TIGR00131 240 DKGALRDFMNEYFaryiaRLTK--MLPLVEERAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHASCDDDYECTCPEI 317

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1964073316 316 DTLVETL-LHSGATGARMTGAGFGGCVVALVETDKFDEVCKQTKAIYLDKIGYEPSFYNVVPEDGVSAI 383
Cdd:TIGR00131 318 DELVCSAaLVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYPKKTGLELTFYVIVSKPGAGSC 386
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 7-56 1.72e-20

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 83.66  E-value: 1.72e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1964073316   7 KQFAKLFNRNDGQVYYSPGRVNLIGEHIDYNGGFVFPCALSYGTYGIAAK 56
Cdd:pfam10509   1 EAFEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
 
Name Accession Description Interval E-value
PRK05322 PRK05322
galactokinase; Provisional
 1-383 3.45e-172

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 485.13  E-value: 3.45e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316   1 MKEKMNKQFAKLFNRNDGQVYYSPGRVNLIGEHIDYNGGFVFPCALSYGTYGIAAKRNDPKIKVFSNPF-SKEIYTFDLD 79
Cdd:PRK05322    2 MKEELKKKFAEVFGEEAEDVFFSPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSANFeDLGIIEFDLD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316  80 HLVKDSKNSWADYIKGSIKAILDKGYKIEYGIDLYIEGTLPVNAGLSSSSSLELLIIYIFDHLNSLNINRPEMAILGKDV 159
Cdd:PRK05322   82 DLSFDKEDDWANYPKGVLKFLQEAGYKIDHGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDLDRLELVKLGQKT 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 160 ENKFIGVNSGIMDQFIIANGQKDHAIMLNTETLEYQQIPLFLDTYSLLIVNTNKQRGLADSKYNERFQECQDSMAILQPK 239
Cdd:PRK05322  162 ENEFIGVNSGIMDQFAIGMGKKDHAILLDCNTLEYEYVPLDLGDYVIVIMNTNKRRELADSKYNERRAECEKALEELQKK 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 240 FGIKNLCSLSDEQLLLSKDMLSD-TIYRRTRHVQTEQKRTILSAKALKAGHIKEFADLMTSSHMSLKNDYEVTGVELDTL 318
Cdd:PRK05322  242 LDIKSLGELTEEEFDEYSYLIKDeTLLKRARHAVTENQRTLKAVKALKAGDLEKFGRLMNASHVSLRDDYEVTGLELDTL 321

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1964073316 319 VETLL-HSGATGARMTGAGFGGCVVALVETDKFDEVCKQTKAIYLDKIGYEPSFYNVVPEDGVSAI 383
Cdd:PRK05322  322 VEAAWkQEGVLGARMTGAGFGGCAIAIVKKDKVEAFKENVGKAYEEKIGYAASFYVAEIGDGAREL 387
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
1-383 1.62e-167

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 473.10  E-value: 1.62e-167
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316   1 MKEKMNKQFAKLFNRNDGQVYYSPGRVNLIGEHIDYNGGFVFPCALSYGTYGIAAKRNDPKIKVFSNPFsKEIYTFDLDH 80
Cdd:COG0153     1 RLERLIEAFEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSADF-DEEVEFDLDD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316  81 LVKDSKNSWADYIKGSIKAILDKGYKIEyGIDLYIEGTLPVNAGLSSSSSLELLIIYIFDHLNSLNINRPEMAILGKDVE 160
Cdd:COG0153    80 LEPGEEDGWANYVRGVAWALQERGYKLG-GFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIGQRAE 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 161 NKFIGVNSGIMDQFIIANGQKDHAIMLNTETLEYQQIPLFLDTYSLLIVNTNKQRGLADSKYNERFQECQDSMAILqpkf 240
Cdd:COG0153   159 NEFVGVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPLEGYALVIVDTNVKHSLADSEYNERRAECEAAAAIL---- 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 241 GIKNLCSLSDEQLLLSKDMLSD-TIYRRTRHVQTEQKRTILSAKALKAGHIKEFADLMTSSHMSLKNDYEVTGVELDTLV 319
Cdd:COG0153   235 GVKSLRDVTLEDLEAARARLGDeVLRRRARHVVTENQRVLEAVEALRAGDLEAFGKLMNASHASLRDDYEVSCPELDTLV 314

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1964073316 320 ETLL-HSGATGARMTGAGFGGCVVALVETDKFDEVCKQTKAIYLDKIGYEPSFYNVVPEDGVSAI 383
Cdd:COG0153   315 ELALaEAGVLGARMTGGGFGGCTIALVPKDAVDEFIEAVAEAYAEKTGLEPDFYVVKPSDGARRL 379
PRK05101 PRK05101
galactokinase; Provisional
 2-380 3.41e-118

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 348.07  E-value: 3.41e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316   2 KEKMNKQFAKLFNRNDGQVYYSPGRVNLIGEHIDYNGGFVFPCALSYGTYGIAAKRNDPKIKVFSNPFSKEIYTFDLDH- 80
Cdd:PRK05101    4 KQKTQSLFAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKRDDRIVRVIAADYDNQQDEFSLDAp 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316  81 LVKDSKNSWADYIKGSIKAILDKGYKIEyGIDLYIEGTLPVNAGLSSSSSLELLIIYIFDHLNSLNINRPEMAILGKDVE 160
Cdd:PRK05101   84 IVPHPEQQWANYVRGVVKHLQERNPDFG-GADLVISGNVPQGAGLSSSASLEVAVGQTFQQLYHLPLSGAEIALNGQEAE 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 161 NKFIGVNSGIMDQFIIANGQKDHAIMLNTETLEYQQIPLfLDTYSLLIVNTNKQRGLADSKYNERFQECQDSMAIlqpkF 240
Cdd:PRK05101  163 NQFVGCNCGIMDQLISALGKKDHALLIDCRSLETKAVPM-PEGVAVVIINSNVKRGLVDSEYNTRRQQCETAARF----F 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 241 GIKNLCSLSDEQLLLSKDMLSDTIYRRTRHVQTEQKRTILSAKALKAGHIKEFADLMTSSHMSLKNDYEVTGVELDTLVE 320
Cdd:PRK05101  238 GVKALRDVTLEQFNAVAAELDPVVAKRARHVITENARTLEAASALAAGDLKRMGELMAESHASMRDDFEITVPQIDTLVE 317

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1964073316 321 TL-LHSGAT-GARMTGAGFGGCVVALVETDKFDEVCKQTKAIYLDKIGYEPSFYNVVPEDGV 380
Cdd:PRK05101  318 IVkAVIGDQgGVRMTGGGFGGCIVALVPEELVEAVRQAVAEQYEAKTGLKETFYVCKASQGA 379
PRK03817 PRK03817
galactokinase; Provisional
 20-383 4.53e-105

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 313.47  E-value: 4.53e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316  20 VYYSPGRVNLIGEHIDYNGGFVFPCALSYGTYgIAAKRNDpKIKVFSNPFsKEIYTFDLDHLVKDskNSWADYIKGSIKA 99
Cdd:PRK03817    2 KVKSPGRVNLIGEHTDYNDGYVLPFAINLYTF-LEIEKSE-KFIFYSENF-NEEKTFELDKLEKL--NSWADYIKGVIWV 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 100 ILDKGYKIEyGIDLYIEGTLPVNAGLSSSSSLELLIIYIFDHLNSLNINRPEMAILGKDVENKFIGVNSGIMDQFIIANG 179
Cdd:PRK03817   77 LEKRGYEVG-GVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLAREAENEFVGVPCGIMDQFAVAFG 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 180 QKDHAIMLNTETLEYQQIPlFLDTYSLLIVNTNKQRGLADSKYNERFQECQDSMAILqpkfGIKNLCSLSDEQLllskDM 259
Cdd:PRK03817  156 KKDHAIFLDTMTLEYEYVP-FPEDYEILVFDTGVKRELASSEYNERRQECEEALKIL----GKKSSKEVTEEDL----SK 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 260 LSDTIYRRTRHVQTEQKRTILSAKALKAGHIKEFADLMTSSHMSLKNDYEVTGVELDTLVETLLHSGATGARMTGAGFGG 339
Cdd:PRK03817  227 LPPLLRKRAGYVLRENERVLKVRDALKEGDIETLGELLTESHWDLADNYEVSCEELDFFVEFALELGAYGARLTGAGFGG 306

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1964073316 340 CVVALVETDKFDEVCKQTKAIYLDKIGYEPSFYNVVPEDGVSAI 383
Cdd:PRK03817  307 SAIALVDKGKFESIGEELLEEYKKRFGIDPKYFVVESSDGVRKI 350
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 2-383 1.17e-101

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 305.98  E-value: 1.17e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316   2 KEKMNKQFAKLFNRNDGQVYYSPGRVNLIGEHIDYNGGFVFPCALSYGTYGIAAKRNDPKIKVFSNPFSKEIYTFDLDHL 81
Cdd:TIGR00131   1 CESIQKIFASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRDDKNVRIYLANADNKFAERSLDLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316  82 VKDSKNS-WADYIKGSIKAILDKGYKIEYGIDLYIEGTLPVNAGLSSSSSLELLIIYIFDHLNSLNINRPEMAILGKDVE 160
Cdd:TIGR00131  81 LDGSEVSdWANYFKGVLHVAQERFNSFPLGADIVCSGNVPTGSGLSSSAAFECAVGAVLQNMGHLPLDSKQILLRIQVAE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 161 NKFIGVNSGIMDQFIIANGQKDHAIMLNTETLEYQQIPLFLDTYSLLIVNTNKQRGLADSKYNERFQECQDSMAILQPKf 240
Cdd:TIGR00131 161 NHFVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPQLGIAFVIANTNVKRTLAPSNYNTRRQECTTAANFLAAT- 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 241 GIKNLCSLSDEQL-----LLSKdmLSDTIYRRTRHVQTEQKRTILSAKALKAGHIKEFADLMTSSHMSLKNDYEVTGVEL 315
Cdd:TIGR00131 240 DKGALRDFMNEYFaryiaRLTK--MLPLVEERAKHVVSENLRVLKAVKAMKDNDFKQFGALMNESHASCDDDYECTCPEI 317

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1964073316 316 DTLVETL-LHSGATGARMTGAGFGGCVVALVETDKFDEVCKQTKAIYLDKIGYEPSFYNVVPEDGVSAI 383
Cdd:TIGR00131 318 DELVCSAaLVNGSGGSRMTGAGFGGCTVHLVPNENVDKVRQAVADKYPKKTGLELTFYVIVSKPGAGSC 386
PRK00555 PRK00555
galactokinase; Provisional
 21-353 4.16e-53

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 180.06  E-value: 4.16e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316  21 YYSPGRVNLIGEHIDYNGGFVFPCALSYGTYGIAAKRNDPKIKVFSNPFSKEIyTFDLDHLVKDSKnSWADYIKGSIKAI 100
Cdd:PRK00555    5 YAAPGRINLIGEHTDYNLGFALPIALPQRTVVTFTPEHTDAITASSDRADGSA-RIPLDTTPGQVT-GWAAYAAGVIWAL 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 101 LDKGYKIEYGIdLYIEGTLPVNAGLSSSSSLELLIIYIFDHLNSLNINRPEMAILGKDVENKFIGVNSGIMDQFIIANGQ 180
Cdd:PRK00555   83 RGAGHPVPGGA-MSITSDVEIGSGLSSSAALECAVLGAVGAATGTRIDRLEQARLAQRAENEYVGAPTGLLDQLAALFGA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 181 KDHAIMLNTETLEYQQIPLFLDT--YSLLIVNTNKQRGLADSKYNERFQECQDSMAILqpkfGIKNLCSLSDEQLLLSKD 258
Cdd:PRK00555  162 PKTALLIDFRDLTVRPVAFDPDAagVVLLLMDSRARHRHAGGEYAARRASCERAAADL----GVSSLRAVQDRGLAALGA 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 259 MLSDTIYRRTRHVQTEQKRTILSAKALKAGHIKEFADLMTSSHMSLKNDYEVTGVELDTLVETLLHSGATGARMTGAGFG 338
Cdd:PRK00555  238 IADPIDARRARHVLTENQRVLDFAAALADSDFTAAGQLLTASHASMRDDFEITTERIDLIADSAVRAGALGARMTGGGFG 317

                         330
                  ....*....|....*
gi 1964073316 339 GCVVALVETDKFDEV 353
Cdd:PRK00555  318 GCVIALVPADRAEDV 332
PLN02865 PLN02865
galactokinase
 7-378 5.94e-41

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 149.18  E-value: 5.94e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316   7 KQFAKLFNRNDGQVYY--SPGRVNLIGEHIDYNGGFVFPCALSYGTYGIAAKRNDPKIKVFSNPFSKEIyTFDLDHLVK- 83
Cdd:PLN02865   17 ERVAAMSGRNSGEVRVvvSPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSGDPEVLLRSAQFEGEV-RFRVDEIQHp 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316  84 --------DSKNSWADYIKGSIKAILDKGYKIEYGIDLYIEGTLPVN-AGLSSSSSLELLIIYIFDHLNSLNINRPEMAI 154
Cdd:PLN02865   96 ianvssdsKEESNWGDYARGAVYALQSRGHALSQGITGYISGSEGLDsSGLSSSAAVGVAYLLALENANNLTVSPEDNIE 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 155 LGKDVENKFIGVNSGIMDQFIIANGQKDHAIMLNTETLEYQQIPL------FLDTYSLLIVNTNKQRGLAD-SKYNERFQ 227
Cdd:PLN02865  176 LDRLIENEYLGLRNGILDQSAILLSRYGCLTFMDCKTLDHKLVSLqfqqpgGEKPFKILLAFSGLRHALTNkPGYNLRVS 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 228 ECQDSMAILQPKFGIKN----LCSLSDEQLLLSKDMLSDTIYRRTRHVQTEQKRTILSAKALKAGHIKEFADLMTSSHMS 303
Cdd:PLN02865  256 ECQEAARFLLEASGNDEleplLCNVEPEVYEAHKCKLEAVLARRAEHYFSENMRVIKGVEAWASGNLEEFGKLISASGLS 335

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1964073316 304 LKNDYEVTGVELDTLVETLLHS-GATGARMTGAGFGGCVVALVETDKFDEVCKQTKAIYLDKigyEPSFYNVVPED 378
Cdd:PLN02865  336 SIENYECGCEPLIQLYEILLKApGVYGARFSGAGFRGCCVAFVDAEMAEEAASFVRDEYEKA---QPELASNINGD 408
PLN02521 PLN02521
galactokinase
 3-364 1.24e-33

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 130.60  E-value: 1.24e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316   3 EKMNKQFAKLFNRNDGQVYYSPGRVNLIGEHIDYNGGFVFPCALSYGTYgIAAKRND--PKIKV--FSNPFSKEIYTFDL 78
Cdd:PLN02521   33 ARLKAAFVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTI-VAIRRAEgsKKLRIanVNDKYTTCTFPADP 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316  79 DHLVKDSKNSWADYI----KGSIKAILDKGYKI--EYGIDLYIEGTLPVNAGLSSSSSLE-LLIIYIFDHLNsLNINRPE 151
Cdd:PLN02521  112 DQEVDLANHKWGNYFicgyKGVFEFLKSKGVDVgpPVGLDVVVDGTVPTGSGLSSSAALVcSAAIAIMAALG-LNFTKKE 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 152 MAILGKDVEnKFIGVNSGIMDQFIIANGQKDHA--IMLNTETLEYQQIPlflDTYSLLIVNTnkqrgLADSK-------- 221
Cdd:PLN02521  191 VAQFTCKCE-RHIGTQSGGMDQAISIMAQQGVAklIDFNPVRATDVQLP---AGGTFVIANS-----LAESNkavtaatn 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 222 YNERFQECQDSMAILQPKFG------IKNLCSLSD---------------------EQLL-------------------- 254
Cdd:PLN02521  262 YNNRVVECRLAAIVLAVKLGmsaeeaISKVKTLSDveglcvsfagshgssdpavavKELLhegpytaeeieeilgeslts 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 255 ------LSKDMLSDT----IYRRTRHVQTEQKR-----TILSAKALKAGHIKEFADLMTSSHMSLKNDYEVTGVELDTLV 319
Cdd:PLN02521  342 ifknspTSLAVLKAAkhfkLHQRAVHVYSEAKRvhafrDTVSSSLSEEEKLKKLGDLMNESHYSCSVLYECSCPELEELV 421

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1964073316 320 ETLLHSGATGARMTGAGFGGCVVALVETDKFDEVCKQTKAIYLDK 364
Cdd:PLN02521  422 KVCRDNGALGARLTGAGWGGCAVALVKEAIVPQFILALKEKFYKS 466
PTZ00290 PTZ00290
galactokinase; Provisional
 9-379 7.28e-32

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 125.32  E-value: 7.28e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316   9 FAKLFN-RNDGQV-----YYSPGRVNLIGEHIDYNGGFVFPCALSYGTYGIAAK-RNDPKIKVFSNPFSKEiyTFDLDHL 81
Cdd:PTZ00290   22 FLETFKvENDADVewllfTFAPGRVNFIGEHVDYMGGYVCPAAVLEGCHILVGRvKHFCDHKLRFATETDE--HFVLDHL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316  82 -VKDSKNSWADYIKGSIKAILDK-GYKIE----YGIDLYIEGTLPVNAGLSSSSSLELLIIYIFDHLNSLN--------- 146
Cdd:PTZ00290  100 gGAKHNKAWTTFVRGAATLRLNRlGVAIDapslQGVCMVVHGTLPMGAGMSASASFGVALLNAINTVVTRRykgcptspg 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 147 --------INRPEMAILGKD---VENKFIGVNSGIMDQFIIANGQKDHAIMLNTETLEYQQI---PLFLDTYSLLIVNTN 212
Cdd:PTZ00290  180 rrysilppMSKEELIELAKQarrIETEFCGVNVGIMDQFISAFAEEDKFMFLDCKSLTFESHdmtPLLGDGACFLLIDSM 259

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 213 KQRGLADSK---YNE-RFQECQDSMAILQPKFGIKNLcSLSD-----EQLLLSKD----------MLSDTIYRRTRHVQT 273
Cdd:PTZ00290  260 IKHDLLGGTagmYNTvRSDQEGAQKKIGKHRYRGKPF-TFSDlvrnpKKYTFDGDvvafmesckpLMTPGEFERGTYNIM 338

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 274 EQKRTI----LSAKALKAGH---IKEFADLMTSSHMSLKNDYEVTGVELDTLVETL-LHSGATGARMTGAGFGGCVVALV 345
Cdd:PTZ00290  339 EQIRTLefikLNDPELPLSReerFRKAGEILNAGHQGMRDLMKITTPELDFIHELInEEKGVAGGRMMGGGFGGCIILLL 418

                         410       420       430
                  ....*....|....*....|....*....|....
gi 1964073316 346 ETDKFDEVCKQTKAIYLDKIGYEPSFYNVVPEDG 379
Cdd:PTZ00290  419 KKNAVDRVVAHVREKFKARFGVENDVYPVVAGDG 452
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 7-56 1.72e-20

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 83.66  E-value: 1.72e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1964073316   7 KQFAKLFNRNDGQVYYSPGRVNLIGEHIDYNGGFVFPCALSYGTYGIAAK 56
Cdd:pfam10509   1 EAFEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
COG2605 COG2605
Predicted kinase related to galactokinase and mevalonate kinase [General function prediction ...
 22-353 1.48e-14

Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only];


Pssm-ID: 442017 [Multi-domain]  Cd Length: 328  Bit Score: 73.67  E-value: 1.48e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316  22 YSPGRVNLIG------EHIDYNGGFVFPCALSYGTYGIAAKRNDPKIKVFSNpfskeiytfDLDHLvkDSKNSWADYIKG 95
Cdd:COG2605     4 RAPLRISFAGggtdlpPYYLEHGGAVLNAAIDKYAYVTLEPRFDGKIRLSSS---------DTERV--ETVDEDDDIPHP 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316  96 SIKAILdKGYKIEYGIDLYIEGTLPVNAGLSSSSSLELLIIYIFDHLNSLNINRPEMAILGKDVENKFIGVNSGIMDQFI 175
Cdd:COG2605    73 VIREAL-KLFGIGDGLEITTDSDAPAGSGLGSSSALTVALLNALHALLGLPLSPYDLARLAYEIERNDLGEPGGKQDQYA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 176 IANGQKDHAIMLNTETLEYQQIPLFLDT-----YSLLIVNTNKQRgladskynerfqecqDSMAILQPKF-GIKNLCSLS 249
Cdd:COG2605   152 AAFGGFNFIEFGPDGRVIVNPLRISPEIlneleSNLLLFYTGITR---------------ESSDILKEQVkNVEDGDEAT 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 250 DEQLLLSKDMlsdtiyrrtrhvqteqkrTILSAKALKAGHIKEFADLM---------TSSHMSlkNDyevtgvELDTLVE 320
Cdd:COG2605   217 LEALHEMKEL------------------ALEMKEALLKGDLDEFGELLnegwelkkrLASGIS--NP------AIDEIYE 270

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1964073316 321 TLLHSGATGARMTGAGFGGCVVALVETDKFDEV 353
Cdd:COG2605   271 LARKAGALGGKLLGAGGGGFLLFYAPPERREAV 303
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 23-345 6.18e-12

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 65.25  E-value: 6.18e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316  23 SPGRVNLIGEHIDYNGGFVFPCALSYGTYGIAAKRNDPKIKVFSNPFSkeiYTFDLDHLVKDSknswADYIKGSIKAILD 102
Cdd:COG1577     1 APGKLILFGEHAVVYGQPAIAVAVDRRATVTVEPSDDDKLRIESPDLG---GTLDLDPLADAA----LRYIKAAIEAALE 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 103 KGYKIEYGIDLYIEGTLPVNAGlssssslellII-YIFDHLNsLNINRPEMAILGKDVENKFIGVNSGiMDQFIIANG-- 179
Cdd:COG1577    74 YLGLPLKGFDIEIDSEIPRKRGlgssaavavaVIrALAAFYG-VELSKEELFKLALEAEKIVHGNPSG-LDTAASTYGgp 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 180 ---QKDHAImlntETLEyqqIPLFLDtysLLIVNTNKQRGLAD--SKYNERFQEcqdsmailqPKFGIKNLCSLSDEqll 254
Cdd:COG1577   152 iyyQRGDRA----EPLE---LPKNLP---LVVGDTGVPASTKElvAKVRKLKER---------NPELYEAFLEEIGD--- 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 255 LSKDMlsdtiyrrtrhvqteqkrtilsAKALKAGHIKEFADLMTSSHMSLKNdYEVTGVELDTLVETLLHSGATGARMTG 334
Cdd:COG1577   210 LVEEA----------------------IEALEEGDLEALGELMNENHGLLRA-LGVSTPELDRLVEAARKAGALGAKLTG 266

                         330
                  ....*....|.
gi 1964073316 335 AGFGGCVVALV 345
Cdd:COG1577   267 AGGGGCVIALA 277
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 23-344 1.25e-11

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 64.62  E-value: 1.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316  23 SPGRVNLIGEHidynggfvfpcALSYGTYGIAAKRNDPKIKVFSNPFSKEIYTFDLDHLVKDSKNSWADYIKGSIKAILD 102
Cdd:TIGR00549   1 APGKIILFGEH-----------AVVYGEPAIAAPIPLRTTVTVIESSDGSFIESDLGRGSLDDAPDELDGLKYVLAEFLS 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 103 K-GYKIEYGIDLYIEGTLPVNAGLSSSSSLELLII-YIFDHLNSlNINRPEMAILGKDVENKFIGVNSGImDQFIIANG- 179
Cdd:TIGR00549  70 RfSELNPPPLEITIESEIPPGRGLGSSAAVAVALIrALADYFGS-ELSKEELAELANEAEKIAHGKPSGI-DTATSTSGg 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 180 ----QKDHaimlNTETLEyqqIPLFLdtySLLIVNTNKQRGLADSkynerfqecqdsmailqpkfgIKNLcslsdEQLLL 255
Cdd:TIGR00549 148 pvyfEKGE----GEFTKL---ISLDG---YFVIADTGVSGSTKEA---------------------VARV-----RQLLE 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 256 SKDMLSDTIYRRTrhvqteQKRTILSAKALKAGHIKEFADLMTSSHMSLKnDYEVTGVELDTLVETLLHSGATGARMTGA 335
Cdd:TIGR00549 192 RFPELIDSIMDAI------GELTLEAKAALQDGDVESLGELMNINQGLLK-ALGVSHPKLDQLVEIARKAGALGAKLTGA 264


                  ....*....
gi 1964073316 336 GFGGCVVAL 344
Cdd:TIGR00549 265 GGGGCMIAL 273
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 282-348 1.77e-10

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 57.09  E-value: 1.77e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 282 AKALKAGHIKEFADLMTSSHMSLKNDyEVTGV---ELDTLVETLLHSGaTGARMTGAGFGGCVVALVETD 348
Cdd:pfam08544   2 LEALLRGDLEELGKLLTESAESLEPL-LVVGIlppELDELLEALLELG-LGAKLSGSGGGPTVFALFKDE 69
PRK03926 PRK03926
mevalonate kinase; Provisional
 23-353 2.70e-10

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 60.84  E-value: 2.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316  23 SPGRVNLIGEHIDYNGGFVFPCALSYGTYgIAAKRNDPKIkVFSNPFSKEiytfdldhlvkDSKNSwadYIKGSIKAILD 102
Cdd:PRK03926    6 APGKIYLFGEHAVVYGKPAIACAIDLRTY-VRAEFNDDSI-YIESDYGKT-----------GEKHP---YVSAAIEKMRE 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 103 KGYKieYGIDLYIEGTLPVNAGLSSSSSLELLIIYIFDHLNSLNINRPEMAILGKDVENKFIGVNSGImDQFIIANGQkd 182
Cdd:PRK03926   70 EADK--DGVTVSITSQIPVGSGLGSSAAVTVATIGALNRLLGLGLSLEEIAKLGHKVELLVQGAASPT-DTYVSTMGG-- 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 183 haimlnteTLEYQQI-PLFLDTYSLLIVNTNKQRGLAD-----SKYNERFQEcqdsmaILQPKFGIKNLCSLSDEQLLLS 256
Cdd:PRK03926  145 --------FVTIPDRkKLPFPECGIVVGYTGSSGSTKElvanvRKLKEEYPE------LIEPILSSIGKISEKGEELILS 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 257 KDmlsdtiYRRtrhvqteqkrtilsakalkaghikeFADLMTSSHmSLKNDYEVTGVELDTLVETLLHSGATGARMTGAG 336
Cdd:PRK03926  211 GD------YVS-------------------------LGELMNINQ-GLLDALGVSTKELSELIYAARTAGALGAKITGAG 258

                         330
                  ....*....|....*..
gi 1964073316 337 FGGCVVALVETDKFDEV 353
Cdd:PRK03926  259 GGGCMVALAAPEKQSEV 275
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 262-359 2.09e-07

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 52.16  E-value: 2.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1964073316 262 DTIYRRTRHVQTEQKrtilsaKALKAGHIKEFADLMTSSHmSLKNDYEVTGVELDTLVETLLHSGATGARMTGAGFGGCV 341
Cdd:PTZ00298  217 NRLLENYNACVSEAK------EALQKGNLFRVGELMNANH-DLCQKLTVSCRELDSIVQTCRTYGALGAKMSGTGRGGLV 289

                          90
                  ....*....|....*....
gi 1964073316 342 VAL-VETDKFDEVCKQTKA 359
Cdd:PTZ00298  290 VALaASEDQRDAIAKAVRA 308
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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