NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1962516670|emb|CAD8521857|]
View 

unnamed protein product, partial [Calcidiscus leptoporus]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 106779)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
AdoMet_MTases super family cl17173
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 9-115 5.27e-19

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


The actual alignment was detected with superfamily member pfam10294:

Pssm-ID: 473071  Cd Length: 172  Bit Score: 77.37  E-value: 5.27e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962516670   9 GSSALRGMRCVELGAGTGVCGIA-CSMLGASRVVLTDLPDALPLLRTNAARACTGSSKRIDVcaLHWGE--PSSLCD-ET 84
Cdd:pfam10294  41 GANNLSGLNVLELGSGTGLVGIAvALLLPGASVTITDLEEALELLKKNIELNALSSKVVVKV--LDWGEnlPPDLFDgHP 118

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1962516670  85 FDVALCVDCVYQPACYASLVATLRQLGAAHS 115
Cdd:pfam10294 119 VDLILAADCVYNEDSFPLLEKTLKDLLGKES 149
 
Name Accession Description Interval E-value
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 9-115 5.27e-19

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 77.37  E-value: 5.27e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962516670   9 GSSALRGMRCVELGAGTGVCGIA-CSMLGASRVVLTDLPDALPLLRTNAARACTGSSKRIDVcaLHWGE--PSSLCD-ET 84
Cdd:pfam10294  41 GANNLSGLNVLELGSGTGLVGIAvALLLPGASVTITDLEEALELLKKNIELNALSSKVVVKV--LDWGEnlPPDLFDgHP 118

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1962516670  85 FDVALCVDCVYQPACYASLVATLRQLGAAHS 115
Cdd:pfam10294 119 VDLILAADCVYNEDSFPLLEKTLKDLLGKES 149
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
1-58 1.55e-09

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 52.60  E-value: 1.55e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1962516670   1 VVAHL--DAIGSSALRGMRCVELGAGTGVCGIACSMLGASRVVLTDL-PDALPLLRTNAAR 58
Cdd:COG2263    30 LAAELlhLAYLRGDIEGKTVLDLGCGTGMLAIGAALLGAKKVVGVDIdPEALEIARENAER 90
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
5-58 6.34e-06

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 43.22  E-value: 6.34e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1962516670   5 LDAIGSSALRGMRCVELGAGTGVCGIACSMLGASRVVLTDL-PDALPLLRTNAAR 58
Cdd:PRK00517  110 LEALEKLVLPGKTVLDVGCGSGILAIAAAKLGAKKVLAVDIdPQAVEAARENAEL 164
 
Name Accession Description Interval E-value
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 9-115 5.27e-19

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 77.37  E-value: 5.27e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962516670   9 GSSALRGMRCVELGAGTGVCGIA-CSMLGASRVVLTDLPDALPLLRTNAARACTGSSKRIDVcaLHWGE--PSSLCD-ET 84
Cdd:pfam10294  41 GANNLSGLNVLELGSGTGLVGIAvALLLPGASVTITDLEEALELLKKNIELNALSSKVVVKV--LDWGEnlPPDLFDgHP 118

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1962516670  85 FDVALCVDCVYQPACYASLVATLRQLGAAHS 115
Cdd:pfam10294 119 VDLILAADCVYNEDSFPLLEKTLKDLLGKES 149
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
1-58 1.55e-09

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 52.60  E-value: 1.55e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1962516670   1 VVAHL--DAIGSSALRGMRCVELGAGTGVCGIACSMLGASRVVLTDL-PDALPLLRTNAAR 58
Cdd:COG2263    30 LAAELlhLAYLRGDIEGKTVLDLGCGTGMLAIGAALLGAKKVVGVDIdPEALEIARENAER 90
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
5-90 1.77e-06

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 44.78  E-value: 1.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962516670   5 LDAIGSSALRGMRCVELGAGTGVCGIACSMLGASRVVLTDL-PDALPLLRTNAARActGSSKRIDVcalhwGEPSSLCDE 83
Cdd:COG2264   139 LEALEKLLKPGKTVLDVGCGSGILAIAAAKLGAKRVLAVDIdPVAVEAARENAELN--GVEDRIEV-----VLGDLLEDG 211


                  ....*..
gi 1962516670  84 TFDVALC 90
Cdd:COG2264   212 PYDLVVA 218
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
5-58 6.34e-06

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 43.22  E-value: 6.34e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1962516670   5 LDAIGSSALRGMRCVELGAGTGVCGIACSMLGASRVVLTDL-PDALPLLRTNAAR 58
Cdd:PRK00517  110 LEALEKLVLPGKTVLDVGCGSGILAIAAAKLGAKKVLAVDIdPQAVEAARENAEL 164
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 11-87 1.53e-05

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 42.06  E-value: 1.53e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1962516670  11 SALRGMRCVELGAGTGVCGIAC-SMLGASRVVLTDL-PDALPLLRTNAARacTGSSKRIDVCALHWGEPSSLcDETFDV 87
Cdd:COG2890   109 PAGAPPRVLDLGTGSGAIALALaKERPDARVTAVDIsPDALAVARRNAER--LGLEDRVRFLQGDLFEPLPG-DGRFDL 184
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 21-90 5.08e-04

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 38.02  E-value: 5.08e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1962516670  21 LGAGTGVCGIACSMLGASRVVLTDL-PDALPLLRTNAARacTGSSKRIDVcALHWGEPsslcDETFDVALC 90
Cdd:pfam06325 168 VGCGSGILAIAALKLGAKKVVGVDIdPVAVRAAKENAEL--NGVEARLEV-YLPGDLP----KEKADVVVA 231
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 4-90 5.03e-03

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 34.78  E-value: 5.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962516670   4 HLDaIGSSAL-------RGMRCVELGAGTGVcgIACSMLGAS---RVVLTDL-PDALPLLRTNAARActgsskRIDVCAL 72
Cdd:COG2813    33 RLD-IGTRLLlehlpepLGGRVLDLGCGYGV--IGLALAKRNpeaRVTLVDVnARAVELARANAAAN------GLENVEV 103

                          90
                  ....*....|....*....
gi 1962516670  73 HWGE-PSSLCDETFDVALC 90
Cdd:COG2813   104 LWSDgLSGVPDGSFDLILS 122
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
7-69 5.97e-03

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 34.63  E-value: 5.97e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1962516670   7 AIGSSALRGMRCVELGAGTGVCGIACSMLGASRVVLTDL-PDALPLLRTNAARActGSSKRIDV 69
Cdd:COG4076    28 AIERVVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVnPDIAAVARRIIAAN--GLSDRITV 89
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 14-95 7.82e-03

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 33.81  E-value: 7.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962516670  14 RGMRCVELGAGTGVCGIACSMLGAsRVVLTDL-PDALPLLRTNAARACTGSS-KRIDVCALhwgepsSLCDETFDVALCV 91
Cdd:COG2226    22 PGARVLDLGCGTGRLALALAERGA-RVTGVDIsPEMLELARERAAEAGLNVEfVVGDAEDL------PFPDGSFDLVISS 94


                  ....
gi 1962516670  92 DCVY 95
Cdd:COG2226    95 FVLH 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH