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Conserved domains on  [gi|1962462531|emb|CAD8544805|]
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unnamed protein product, partial [Calcidiscus leptoporus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UhpC super family cl34453
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-131 1.10e-14

Sugar phosphate permease [Carbohydrate transport and metabolism];


The actual alignment was detected with superfamily member COG2271:

Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 68.74  E-value: 1.10e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   1 AQYGLLASVGFAAFfALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTAL 80
Cdd:COG2271    45 AQLGLLASAFFLGY-ALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLI 123

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1962462531  81 AKLFAEERRATAFGLYSSGVYLGGALAA-LSIVLDDPLGWRGISYLCAGCGA 131
Cdd:COG2271   124 AEWFPPKERGRALGIFNAGGPLGGALAPpLLGWLLAAFGWRAAFLILGLPGL 175
 
Name Accession Description Interval E-value
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-131 1.10e-14

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 68.74  E-value: 1.10e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   1 AQYGLLASVGFAAFfALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTAL 80
Cdd:COG2271    45 AQLGLLASAFFLGY-ALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLI 123

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1962462531  81 AKLFAEERRATAFGLYSSGVYLGGALAA-LSIVLDDPLGWRGISYLCAGCGA 131
Cdd:COG2271   124 AEWFPPKERGRALGIFNAGGPLGGALAPpLLGWLLAAFGWRAAFLILGLPGL 175
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 1-130 5.81e-14

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 66.83  E-value: 5.81e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   1 AQYGLLASVgFAAFFALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTAL 80
Cdd:cd17319    38 TQYGLIASA-FFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKAL 116

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1962462531  81 AKLFAEERRATAFGLYSSGVYLGGALAA-LSIVLDDPLGWRGISYLCAGCG 130
Cdd:cd17319   117 AEWFPARERGRATGLFNSGAPLGAAIGPpLSGWLLLLFGWRWAFIIEGLLG 167
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 1-130 1.39e-10

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 57.39  E-value: 1.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   1 AQYGLLASvGFAAFFALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTAL 80
Cdd:TIGR00881  30 TDLGLLLS-SFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTV 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1962462531  81 AKLFAEERRATAFGLYSSGVYLGGALAA--LSIVLDDPLGWRGISYLCAGCG 130
Cdd:TIGR00881 109 TKWFSRSERGTWVSFWNCSHNVGGGLLPplVLFGIAELYSWHWVFIVPGIIA 160
MFS_1 pfam07690
Major Facilitator Superfamily;
6-128 2.76e-09

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 53.58  E-value: 2.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   6 LASVGFAAFFALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTALAKLFA 85
Cdd:pfam07690  36 LLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFP 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1962462531  86 EERRATAFGLYSSGVYLGGALAA-LSIVLDDPLGWRGISYLCAG 128
Cdd:pfam07690 116 PEERGRALGLVSAGFGLGAALGPlLGGLLASLFGWRAAFLILAI 159
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 20-125 2.82e-03

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 36.48  E-value: 2.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531  20 LVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVL--LGFAQAFTNPAAYTALAklFAEERRATAFGLYS 97
Cdd:PRK11551   68 LLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLtgVGLGGALPNLIALTSEA--VGPRLRGTAVSLMY 145

                          90       100
                  ....*....|....*....|....*....
gi 1962462531  98 SGVYLGGALAAL-SIVLDDPLGWRGISYL 125
Cdd:PRK11551  146 CGVPFGGALASViGVLAAGDAAWRHIFYV 174
 
Name Accession Description Interval E-value
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
1-131 1.10e-14

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 68.74  E-value: 1.10e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   1 AQYGLLASVGFAAFfALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTAL 80
Cdd:COG2271    45 AQLGLLASAFFLGY-ALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLI 123

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1962462531  81 AKLFAEERRATAFGLYSSGVYLGGALAA-LSIVLDDPLGWRGISYLCAGCGA 131
Cdd:COG2271   124 AEWFPPKERGRALGIFNAGGPLGGALAPpLLGWLLAAFGWRAAFLILGLPGL 175
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 1-130 5.81e-14

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 66.83  E-value: 5.81e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   1 AQYGLLASVgFAAFFALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTAL 80
Cdd:cd17319    38 TQYGLIASA-FFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKAL 116

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1962462531  81 AKLFAEERRATAFGLYSSGVYLGGALAA-LSIVLDDPLGWRGISYLCAGCG 130
Cdd:cd17319   117 AEWFPARERGRATGLFNSGAPLGAAIGPpLSGWLLLLFGWRWAFIIEGLLG 167
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 2-120 2.85e-13

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 64.95  E-value: 2.85e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   2 QYGLLASVGFAAFFALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTALA 81
Cdd:cd17328    34 SLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIA 113

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1962462531  82 KLFAEERRATAFGLYSSGVYLGGALAAL--SIVLDDPLGWR 120
Cdd:cd17328   114 DLFPKEKRTRALGVFYFAIPLGSGLGYVvgGLVAQATGGWR 154
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 13-130 9.99e-12

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 60.65  E-value: 9.99e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531  13 AFF---ALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAW--QASATSFAEVLASRVLLGFAQAFTNPAAYTALAKLFAEE 87
Cdd:cd17380    42 SFFwgyALTQVLGGYLADRFGGKKVLLLAVALWSLATLLtpLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVS 121

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1962462531  88 RRATAFGLYSSGVYLGGALA-ALSIVLDDPLGWRGISYLCAGCG 130
Cdd:cd17380   122 ERSRAVSIVTAGSYLGTLLGgLIGPLLLEYYGWPSVFYFFGLLG 165
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 1-130 1.39e-10

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 57.39  E-value: 1.39e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   1 AQYGLLASvGFAAFFALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTAL 80
Cdd:TIGR00881  30 TDLGLLLS-SFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTV 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1962462531  81 AKLFAEERRATAFGLYSSGVYLGGALAA--LSIVLDDPLGWRGISYLCAGCG 130
Cdd:TIGR00881 109 TKWFSRSERGTWVSFWNCSHNVGGGLLPplVLFGIAELYSWHWVFIVPGIIA 160
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
6-131 2.41e-10

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 56.52  E-value: 2.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   6 LASVGFAAFFALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTALAKLFA 85
Cdd:COG2814    49 LVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVP 128

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1962462531  86 EERRATAFGLYSSGVYLGGALAA-LSIVLDDPLGWRGISYLCAGCGA 131
Cdd:COG2814   129 PERRGRALGLLGAGLGLGPALGPlLGGLLADLFGWRWVFLVNAVLAL 175
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
1-120 3.41e-10

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 56.04  E-value: 3.41e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   1 AQYGLLASVGFAaFFALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTAL 80
Cdd:COG2223    40 AQLGLLFAIPVL-VGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALV 118

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1962462531  81 AKLFAEERRATAFGLYSSGVYLGGALAA-LSIVLDDPLGWR 120
Cdd:COG2223   119 SKWFPPDRRGLALGLAAGGGNLGAAVAAfLAPLLIAAFGWR 159
MFS_1 pfam07690
Major Facilitator Superfamily;
6-128 2.76e-09

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 53.58  E-value: 2.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   6 LASVGFAAFFALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTALAKLFA 85
Cdd:pfam07690  36 LLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFP 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1962462531  86 EERRATAFGLYSSGVYLGGALAA-LSIVLDDPLGWRGISYLCAG 128
Cdd:pfam07690 116 PEERGRALGLVSAGFGLGAALGPlLGGLLASLFGWRAAFLILAI 159
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 1-131 8.84e-09

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 52.19  E-value: 8.84e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   1 AQYGLLASVgFAAFFALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTAL 80
Cdd:cd17325    31 AQIGLIVAA-YALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALI 109

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1962462531  81 AKLFAEERRATAFGLYSSGVYLGGAL-AALSIVLDDPLGWRGISYLCAGCGA 131
Cdd:cd17325   110 ADIAPPEERGRAMGIFSSAIGLGFLIgPLLGGLLADALGYRAPFLVCAALAL 161
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
1-121 2.78e-08

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 50.64  E-value: 2.78e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   1 AQYGLLASVGFAAFfALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAyTAL 80
Cdd:COG2807    53 TQAGLLTTLPLLAF-GLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLL-PGL 130

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1962462531  81 AKLFAEERRATAFGLYSSGVYLGGALAA-LSIVLDDPLGWRG 121
Cdd:COG2807   131 IKRWFPDRVGLMTGLYTAAMGLGAALAAgLTVPLAAALGWRG 172
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 1-128 4.36e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 50.27  E-value: 4.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   1 AQYGLLASVgFAAFFALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTAL 80
Cdd:cd17325   235 AQIGLLFGA-QGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALL 313

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1962462531  81 AKLFAEERRATAFGLYSSGVYLGGALAALSI-VLDDPLGWRGISYLCAG 128
Cdd:cd17325   314 ADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGgFLYDAFGFATPFLAAAA 362
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 1-111 4.98e-08

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 49.93  E-value: 4.98e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   1 AQYGLLASVGFAAFfALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTAL 80
Cdd:cd17475    31 AQVGLLLSALNLGV-AVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAI 109

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1962462531  81 AKLFAEERRATAFGLYSSGVYLGGALAALSI 111
Cdd:cd17475   110 MRWFPPRERGLAMGIRQTGVPLGGALAAALL 140
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 9-122 7.26e-08

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 49.48  E-value: 7.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   9 VGFAAFFALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTALAKLFAEER 88
Cdd:cd17321    38 NAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGER 117

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1962462531  89 RATAFGLYSSGVYLGGALAA-LSIVLDDPLGWRGI 122
Cdd:cd17321   118 RGRALGLWGAVVGIGAALGPlLGGLLLELFGWRWI 152
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 12-125 1.75e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 48.34  E-value: 1.75e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531  12 AAFFALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTALAKLFAEERRAT 91
Cdd:cd17473    45 ALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAK 124

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1962462531  92 AFGLYSSGVYLGGALAALSIVLDDPLGWRGISYL 125
Cdd:cd17473   125 MLGLQSAAMSLGGVVFLLLGGALAEIGWRAPFLV 158
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 6-131 1.81e-07

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 48.34  E-value: 1.81e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   6 LASVGFAAFFALSSLVAGGAVD-RLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTALAKLF 84
Cdd:cd17474   238 LLFAGWSVLLALGSLFVGRLLKkRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELA 317

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1962462531  85 AEERRATAFGLYSSGVYLGGALAALSI-VLDDPLGWRGISYLCAGCGA 131
Cdd:cd17474   318 PEEERGTASSLYNFVRFLGQAVGPLLFgLLLEIFGLSAPFLVGAAIAL 365
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 6-127 5.21e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 47.04  E-value: 5.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   6 LASVGFAAFFALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTALAKLFA 85
Cdd:cd06174    35 LLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFP 114

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1962462531  86 EERRATAFGLYSSGVYLGGALAAL---SIVLDDPLGWRGISYLCA 127
Cdd:cd06174   115 ERERGRALGLLQAFGSVGGILGPLlggILASSLGFGWRAVFLIAA 159
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 1-131 1.49e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 45.62  E-value: 1.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   1 AQYGLLASVgFAAFFALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTAL 80
Cdd:cd17324    34 AQAGLLVSA-YALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYA 112

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1962462531  81 AKLFAEERRATAFGLYSSGVYLGGALAA-LSIVLDDPLGWRGISYLCAGCGA 131
Cdd:cd17324   113 ADLVPPEKRGRAIGLVFSGLTLGLVLGRpLGGLLGQLLGWRAAFLAIAVLAL 164
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 1-121 2.67e-06

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 44.85  E-value: 2.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   1 AQYGLLASVGFAAFFaLSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASR-VLLGFAQAFTNPAAYTA 79
Cdd:cd17352    38 SDIAWIGSLLLGVSL-FSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTYgVLGGLGLGLIYSPAIVI 116

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1962462531  80 LAKLFaEERRATAFGLYSSGVYLGGAL-AALSIVLDDPLGWRG 121
Cdd:cd17352   117 VGQYF-EKKRGLATGIAVAGSGVGTFVfPPLLRYLLDNYGWRG 158
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 5-109 2.87e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 44.91  E-value: 2.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   5 LLASVGFAAFFAlsSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTALAKLF 84
Cdd:cd17329    40 VLALSAVAGIVA--SLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVT 117

                          90       100
                  ....*....|....*....|....*
gi 1962462531  85 AEERRATAFGLYSSGVYLGGALAAL 109
Cdd:cd17329   118 TPENRTRAFSLLYWAINLGVAIGPL 142
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 11-130 2.88e-06

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 44.92  E-value: 2.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531  11 FAAFFA---LSSLVAGGAVDRLEPRRILTLSGLAWS--GAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTALAKLFA 85
Cdd:cd17318    62 LSSFFYgyiLTQIPGGYLAEKYGAKRVLGYSILITAllTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAP 141

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1962462531  86 EERRATAFGLYSSGVYLGGALA-ALSIVLDDPLGWRGISYLCAGCG 130
Cdd:cd17318   142 PLERSRLTSIAYSGSQFGTVIAmPLSGFLCESLGWPSIFYIFGGLG 187
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 2-109 3.05e-06

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 44.93  E-value: 3.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   2 QYGLLASVgFAAFFALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTALA 81
Cdd:cd17327    42 QYNWGNTV-FYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLG 120

                          90       100
                  ....*....|....*....|....*...
gi 1962462531  82 KLFAEERRATAFGLYSSGVYLGGALAAL 109
Cdd:cd17327   121 MWYKREEQAKRIAFFYAAAGLGSIFGGL 148
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
6-107 5.59e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 44.19  E-value: 5.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   6 LASVGFAAFFALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTALAKLFA 85
Cdd:COG2814   247 LLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAP 326

                          90       100
                  ....*....|....*....|..
gi 1962462531  86 EERRATAFGLYSSGVYLGGALA 107
Cdd:COG2814   327 PEARGRASGLYNSAFFLGGPLA 348
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 1-125 8.86e-06

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 43.50  E-value: 8.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   1 AQYGLLASVGFAAFfALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTAL 80
Cdd:TIGR00895  52 VQLGFLFSAGLIGM-AFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALV 130

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1962462531  81 AKLFAEERRATAFGLYSSGVYLGGALAA-LSIVLDDPLGWRGISYL 125
Cdd:TIGR00895 131 SEYAPKRFRGTAVGLMFCGYPIGAAVGGfLAGWLIPVFGWRSLFYV 176
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 16-131 1.00e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 43.35  E-value: 1.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531  16 ALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTALAKLFAEERRATAFGL 95
Cdd:cd17489    45 LLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGY 124

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1962462531  96 YSSGVYLGGALA-ALSIVLDDPLGWRGISYLCAGCGA 131
Cdd:cd17489   125 YGLATTLAMALGpALGLFLYQHLGFAVLFIVAAVLAL 161
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 1-127 1.05e-05

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 43.26  E-value: 1.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   1 AQYGLLASVGFAAFfALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTAL 80
Cdd:COG0477    49 AQLGWIVSAYLLGR-AIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALI 127

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1962462531  81 AKLFAEERRATAFGLYSSGVYLGGALAAL-SIVLDDPLGWRGISYLCA 127
Cdd:COG0477   128 AELFPARERGRALGLWGAAIGLGLALGPLlGGLLVAALGWRWIFLINA 175
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 7-125 1.56e-05

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 42.95  E-value: 1.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   7 ASVGFAAFFALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTALAKLFAE 86
Cdd:cd17503    36 VITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPP 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1962462531  87 ERRATAFGLYSSGVYLGGALA-ALSIVLDDPLGWRGISYL 125
Cdd:cd17503   116 EKRGAAMGLVGLVILLAPAIGpTLGGWLTDNLSWRWIFYI 155
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 4-109 1.87e-05

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 42.64  E-value: 1.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   4 GLLASV-GFAAffALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTALAK 82
Cdd:cd17391   243 GLVFSAtGVSS--LLSAPRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAK 320

                          90       100
                  ....*....|....*....|....*..
gi 1962462531  83 LFAEERRATAFGLYSSGVYLGGALAAL 109
Cdd:cd17391   321 ITPKEVAGRIFGYNQSFQYLGNVAGPL 347
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 2-131 6.54e-05

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 41.11  E-value: 6.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   2 QYGLLASVgFAAFFALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTALA 81
Cdd:cd17312    39 DLGIIGSA-FLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLG 117

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1962462531  82 KLFAEERRATAFGLYSSGVYLGGALAALSI-VLDDPLGWRGISYLCAGCGA 131
Cdd:cd17312   118 NWFSKKERGTVYGIWSTSHNFGGILAPILAaSLASYYGWRAAFLVPGIVGL 168
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 1-128 7.36e-05

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 40.65  E-value: 7.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   1 AQYGLLASVGFAAFfALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTAL 80
Cdd:cd17365    34 AQLGPVGSAALFGM-AIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLV 112

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1962462531  81 AKLFAEERRATAFGLYSSGVYLGGALAA-LSIVLDDPLGWRGISYLCAG 128
Cdd:cd17365   113 SEYAPARRRSLAVTLMFCGYPLGAALGGfLAAALIPAFGWRSVFLLGGV 161
MFS_CitA cd17368
Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton ...
 1-107 8.02e-05

Citrate-proton symporter of the Major Facilitator Superfamily of transporters; Citrate-proton symporter, also called citrate carrier protein or citrate transporter or citrate utilization protein A (CitA), is a proton symporter that functions in the uptake of citrate across the boundary membrane. It allows the utilization of citrate as a sole source of carbon and energy. In Klebsiella pneumoniae, the gene encoding this protein is called citH, instead of citA, which is the case for Escherichia coli and other organisms. CitA belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340926 [Multi-domain]  Cd Length: 407  Bit Score: 40.82  E-value: 8.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   1 AQYGLLASVGFAAFFALSSLVAGGAVDRLEPRRILTLSGLAW----SGAMAWQASATSFAEVLASRVLLGFAQAFTNPAA 76
Cdd:cd17368   257 ARDSFLVTLLAGVANFIWAPLGGALSDRIGRRPVLLVITLAAlvtlYPVFAWLTAAPSFGRLLLVLLVLSFFFGMYGGAM 336

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1962462531  77 YTALAKLFAEERRATAFGL-YSSGVYLGGALA 107
Cdd:cd17368   337 VVALVELFPVRVRSTGFSLvYALAVAIFGGFA 368
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
1-128 1.28e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 40.22  E-value: 1.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   1 AQYGLLASVGFAAFFaLSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTAL 80
Cdd:COG0738    43 AQAGLLLFAFFLGYL-LASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYV 121

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1962462531  81 AKLFAEERRA---TAFGLYSSGVYLGGALAALSIVLDDPLGWRGISYLCAG 128
Cdd:COG0738   122 AALGPETAASrlnLLHAFFSLGALLGPLLGGLLILLGLSLSWHLPYLILAV 172
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 6-107 2.75e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 39.08  E-value: 2.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   6 LASVGFAAFFALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQA---SATSFAEVLASRVLLGFAQAFTNPAAYTALAK 82
Cdd:cd17321   208 LALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLAllgADSSVWLLLPGLVLLGLGLGLFATPLTNAALS 287

                          90       100
                  ....*....|....*....|....*
gi 1962462531  83 LFAEERRATAFGLYSSGVYLGGALA 107
Cdd:cd17321   288 SVPKEKAGAASGILNTARQLGGALG 312
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 4-128 3.23e-04

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 39.07  E-value: 3.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   4 GLLASVGFAAFfaLSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTALAKL 83
Cdd:cd17324   238 GLLLLFGVAGV--VGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL 315

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1962462531  84 fAEERRATAFGLYSSGVYLGGAL-AALSIVLDDPLGWRGISYLCAG 128
Cdd:cd17324   316 -APEARGLASSLYLAAYNLGGALgAALGGLVLDHGGWAGVGWVGAA 360
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 1-113 3.59e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 38.69  E-value: 3.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   1 AQYGLLASVgFAAFFALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAyTAL 80
Cdd:cd17478    31 AQAGLLVSV-FSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEG-ARL 108

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1962462531  81 AKLFAEERRATAFGLYSSGVYLGGALAALSIVL 113
Cdd:cd17478   109 ASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAA 141
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 9-111 4.94e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 38.29  E-value: 4.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   9 VGFAAFFALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTALAKLFAEER 88
Cdd:cd17370   241 ALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAEL 320

                          90       100
                  ....*....|....*....|...
gi 1962462531  89 RATAFGLYSSGVYLGGALAALSI 111
Cdd:cd17370   321 RGTAYGLFNTVVGIGWLLASLIA 343
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 5-125 5.65e-04

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 38.33  E-value: 5.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   5 LLASVGFAAFFALSSLVAGGAVDrLEPRRILTLSGLAWSGAMA-WQASATSFAEVLASRVLLGFAQAFTNPAAYTALAKL 83
Cdd:cd17323    37 NLGVSLFVLGFGLGPLIWAPLSE-LYGRRPVYLVSLFIFVIFQiGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADL 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1962462531  84 FAEERRATAFGLYSSGVYLGGALAAL-SIVLDDPLGWRGISYL 125
Cdd:cd17323   116 FTPEERGKAMGVYSLGPLLGPALGPIiGGFITQSLGWRWIFWF 158
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 6-129 5.71e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 38.34  E-value: 5.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   6 LASVGFAAFFALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTALAKLFA 85
Cdd:cd17489   231 LFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVP 310

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1962462531  86 EERRATAFGLYSSGVYLGGAL-AALSIVLDDPLGWRGISYLCAGC 129
Cdd:cd17489   311 PHRRGAANGTFFIFFDLGIGLgGLLLGLVAELFGYRAMFLLAAVV 355
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-131 7.83e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 37.79  E-value: 7.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   1 AQYGLLASVGFAAFFALSSLVAGGAVDRLEPRR-ILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTA 79
Cdd:cd06174   238 VAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKpLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFAL 317

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1962462531  80 LAKLFAEERRATAFGLYSSGVYLGGALAAL--SIVLDDPLGWRGISYLCAGCGA 131
Cdd:cd06174   318 IAELFPPEIRGTAFGLLNTFGFLGGAIGPLlaGFLLAATFGLTGAFLVLAVLLL 371
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
6-131 1.30e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 37.16  E-value: 1.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   6 LASVGFAAFFALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAW--QASATSFAEVLASRVLLGFAQAFTNPAAYTALAKL 83
Cdd:COG2271   220 LLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALllLALLPSPALAIALLFLAGFGLGGAFGLLWALAAEL 299

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1962462531  84 FAEERRATAFGLYSSGVYLGGALAALSI-VLDDPLGWRGISYLCAGCGA 131
Cdd:COG2271   300 FPKKARGTASGLVNTFGFLGGALGPLLVgYLLDATGYQAAFLLLAALAL 348
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 16-131 1.71e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 36.79  E-value: 1.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531  16 ALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAfTNPAAYTALAKLFAEERRATAFGL 95
Cdd:cd17504    45 AVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGA-VFPLAFALVREEFPPERVPVAQGI 123

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1962462531  96 YSSGVYLGGALAA-LSIVLDDPLGWRGISYLCAGCGA 131
Cdd:cd17504   124 LSATFGIGAGIGLpLGGWIVQHLGWRWIFWTAAPVAV 160
MFS_GLUT10_Class3 cd17436
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 2-120 1.73e-03

Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340994 [Multi-domain]  Cd Length: 376  Bit Score: 37.09  E-value: 1.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   2 QYGLLASVGFAAFFAlsSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTALA 81
Cdd:cd17436    38 QEALVSALLIGALLA--SLIGGFLIDRHGRRTSILGSNLVLLAGSLILTLAGSFFWLVIGRAVVGFAISVSSMACCIYVS 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1962462531  82 KLFAEERRATAFGLYSSGVYLGGALA-ALSIVLDD-PLGWR 120
Cdd:cd17436   116 EMVTPHQRGLLVSLYEAGITVGILISyALNYFFSNvLTGWR 156
MFS_1 pfam07690
Major Facilitator Superfamily;
11-108 1.89e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 36.63  E-value: 1.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531  11 FAAFFALSSLVAGGAVDRLEPRRILTLSGLA---WSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTALAKLFAEE 87
Cdd:pfam07690 244 GGLLGAIGRLLLGRLSDRLGRRRRLLLALLLlilAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKE 323

                          90       100
                  ....*....|....*....|.
gi 1962462531  88 RRATAFGLYSSGVYLGGALAA 108
Cdd:pfam07690 324 ERGTASGLYNTAGSLGGALGP 344
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
 1-119 2.68e-03

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 36.51  E-value: 2.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   1 AQYGLLASVGFAAFFaLSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTAL 80
Cdd:cd06180    34 AQAGWIATANYAGYL-VGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRFLAGAASAFVFVFGSNLV 112

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1962462531  81 AKLFAEERRATAFGLYSSGVYLGGALAALSIVLDDPLGW 119
Cdd:cd06180   113 LHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGGL 151
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 1-129 2.73e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 36.44  E-value: 2.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   1 AQYGLLASVgFAAFFALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTAL 80
Cdd:cd06173   244 AGYGLLLAA-FGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLL 322

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1962462531  81 AKLFAEERRATAFGLYSSGVYLGGAL-AALSIVLDDPLGWRGISYLCAGC 129
Cdd:cd06173   323 QLRVPDELRGRVFSVYNALNSGAMPLgALLAGLLADALGLSAVFLLAGAL 372
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 20-125 2.82e-03

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 36.48  E-value: 2.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531  20 LVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVL--LGFAQAFTNPAAYTALAklFAEERRATAFGLYS 97
Cdd:PRK11551   68 LLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLtgVGLGGALPNLIALTSEA--VGPRLRGTAVSLMY 145

                          90       100
                  ....*....|....*....|....*....
gi 1962462531  98 SGVYLGGALAAL-SIVLDDPLGWRGISYL 125
Cdd:PRK11551  146 CGVPFGGALASViGVLAAGDAAWRHIFYV 174
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 4-127 3.04e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 36.04  E-value: 3.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   4 GLLASVGFAAFFaLSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTALAKL 83
Cdd:cd17316    39 GLLFAAGFLGRP-IGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEF 117

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1962462531  84 FAEERRATAFGLYSSGVYLGGALAAL-----SIVLDDPLGWRGISYLCA 127
Cdd:cd17316   118 APSKRRGFALGLLQSGWALGALLAALvasllIPLLSGDWGWRILFLIGA 166
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 1-121 3.50e-03

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 36.13  E-value: 3.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   1 AQYGLLASVgFAAFFALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTAL 80
Cdd:cd17371    34 AEAGLLGTV-TLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAAGAALM 112

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1962462531  81 AKLFAEERRATAFGLYSSGVYLGGALAALSI-----VLDDPLGWRG 121
Cdd:cd17371   113 AEYVPARHRGKALGYVQSGWAVGWLLATLLAallfpLLPPEIAWRV 158
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
 1-113 3.73e-03

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 36.07  E-value: 3.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   1 AQYGLLASvGFAAFFALSSLVAGGAVDRLEPRRILT----LSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAA 76
Cdd:cd17345    38 TEIGLIGS-ALSIAYGLSKFVMGNLSDRSNPKRFLAigliLSAIINILIGFVPSATSSVGLMFILLFLNGWFQGMGWPPS 116

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1962462531  77 YTALAKLFAEERRATAFGLYSSGVYLGGALAALSIVL 113
Cdd:cd17345   117 GRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGL 153
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 16-68 4.15e-03

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 35.63  E-value: 4.15e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1962462531  16 ALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFA 68
Cdd:cd17315    48 AIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLG 100
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 1-109 4.74e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 35.62  E-value: 4.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   1 AQYGLLASVgFAAFFALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTAL 80
Cdd:cd17474    34 AQVGLLITA-FTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLI 112

                          90       100
                  ....*....|....*....|....*....
gi 1962462531  81 AKLFAEERRATAFGLYSSGVYLGGALAAL 109
Cdd:cd17474   113 GDLFEGGERAKAMGLYEAALGLGIAVGPL 141
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 17-120 5.67e-03

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 35.41  E-value: 5.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531  17 LSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTALAKLFAEERRATAFGLY 96
Cdd:cd17362    54 LGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLK 133

                          90       100
                  ....*....|....*....|....*.
gi 1962462531  97 SSGVYLGGALAALS--IVLDDPLGWR 120
Cdd:cd17362   134 ELFIVLGILLGYVSgyAFADVVGGWR 159
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 5-113 7.17e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 35.27  E-value: 7.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   5 LLASVGFAAFFALSSLVAGGAVDRLEPRRILTLSGLAW--SGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTALAK 82
Cdd:cd17316   216 SLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSgiLALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAE 295

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1962462531  83 LFAEERRATAFGLYSSGVYLGGALAALSIVL 113
Cdd:cd17316   296 LFPTEVRATGVGLSYNLGRLGGGGAPPLIAL 326
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 1-109 8.31e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 34.86  E-value: 8.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1962462531   1 AQYGLLASVgFAAFFALSSLVAGGAVDRLEPRRILTLSGLAWSGAMAWQASATSFAEVLASRVLLGFAQAFTNPAAYTAL 80
Cdd:cd17473   233 ALIGLALAI-ASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWA 311

                          90       100
                  ....*....|....*....|....*....
gi 1962462531  81 AKLFAEERRATAFGLYSSGVYLGGALAAL 109
Cdd:cd17473   312 MSLVPPELRGRAMGIVTSAFFLGQFLSPL 340
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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