RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959422415  860 FGVSLDFLVEKEGTESTHGVGPGALRVPALVDDAVSAMRQMDMSVEGVFRKNGNIRRLKEISEMIDNKYDQV-DLTKETP 938
Cdd:cd04397      1 FGVPLEILVEKFGADSTLGVGPGKLRIPALIDDIISAMRQMDMSVEGVFRKNGNIRRLKELTEEIDKNPTEVpDLSKENP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959422415  939 VQIAALLKKFLREMPDPLLTFKLHNLFVISQKIPDPEKQKRLLHLTCCLLPKAHRDTMEVLFAFLNWTSSFSHVDEDTGS 1018
Cdd:cd04397     81 VQLAALLKKFLRELPDPLLTFKLYRLWISSQKIEDEEERKRVLHLVYCLLPKYHRDTMEVLFSFLKWVSSFSHIDEETGS 160

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1959422415 1019 KMDIHNLATVITPNILYPNTKNS-TVDESFLAIEAVNALITYNDTMCEIPEDL 1070
Cdd:cd04397    161 KMDIHNLATVITPNILYSKTDNPnTGDEYFLAIEAVNYLIENNEEFCEVPDEL 213

The second LIM domain of Lrg1p, a LIM and RhoGap domain containing protein; The second LIM domain of Lrg1p, a LIM and RhoGap domain containing protein: The members of this family contain three tandem repeats of LIM domains and a Rho-type GTPase activating protein (RhoGap) domain. Lrg1p is a Rho1 GTPase-activating protein required for efficient cell fusion in yeast. Lrg1p-GAP domain strongly and specifically stimulates the GTPase activity of Rho1p, a regulator of beta (1-3)-glucan synthase in vitro. The LIM domain is 50-60 amino acids in size and shares two characteristic zinc finger motifs. The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. LIM domains function as adaptors or scaffolds to support the assembly of multimeric protein.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1959422415  190 CHECGGALRGSYITALDHKYHIEHFTCSVCPTVFGAQDSYYEHEGRVYCHFHY 242
Cdd:cd09392      1 CFKCGGALRGSYITALGRKYHVEHFTCSVCPTVFGPNDSYYEHEGKIYCHYHY 53

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959422415  860 FGVSLDFLVEKEGTESTHGVGPGALRVPALVDDAVSAMRQMDMSVEGVFRKNGNIRRLKEISEMIDNKYDQV-DLTKETP 938
Cdd:cd04397      1 FGVPLEILVEKFGADSTLGVGPGKLRIPALIDDIISAMRQMDMSVEGVFRKNGNIRRLKELTEEIDKNPTEVpDLSKENP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959422415  939 VQIAALLKKFLREMPDPLLTFKLHNLFVISQKIPDPEKQKRLLHLTCCLLPKAHRDTMEVLFAFLNWTSSFSHVDEDTGS 1018
Cdd:cd04397     81 VQLAALLKKFLRELPDPLLTFKLYRLWISSQKIEDEEERKRVLHLVYCLLPKYHRDTMEVLFSFLKWVSSFSHIDEETGS 160

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1959422415 1019 KMDIHNLATVITPNILYPNTKNS-TVDESFLAIEAVNALITYNDTMCEIPEDL 1070
Cdd:cd04397    161 KMDIHNLATVITPNILYSKTDNPnTGDEYFLAIEAVNYLIENNEEFCEVPDEL 213

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959422415   885 RVPALVDDAVSAMRQMDMSVEGVFRKNGNIRRLKEISEMIDN-KYDQVDLTKETPVQIAALLKKFLREMPDPLLTFKLHN 963
Cdd:smart00324    2 PIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSgPDPDLDLSEYDVHDVAGLLKLFLRELPEPLITYELYE 81

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1959422415   964 LFVISQKIPDPEKQKRLLHLTCCLLPKAHRDTMEVLFAFLNWTSSFSHVdedtgSKMDIHNLATVITPNILYPNTKNS 1041
Cdd:smart00324   82 EFIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEE-----NKMTARNLAIVFGPTLLRPPDGEV 154

The second LIM domain of Lrg1p, a LIM and RhoGap domain containing protein; The second LIM domain of Lrg1p, a LIM and RhoGap domain containing protein: The members of this family contain three tandem repeats of LIM domains and a Rho-type GTPase activating protein (RhoGap) domain. Lrg1p is a Rho1 GTPase-activating protein required for efficient cell fusion in yeast. Lrg1p-GAP domain strongly and specifically stimulates the GTPase activity of Rho1p, a regulator of beta (1-3)-glucan synthase in vitro. The LIM domain is 50-60 amino acids in size and shares two characteristic zinc finger motifs. The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. LIM domains function as adaptors or scaffolds to support the assembly of multimeric protein.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1959422415  190 CHECGGALRGSYITALDHKYHIEHFTCSVCPTVFGAQDSYYEHEGRVYCHFHY 242
Cdd:cd09392      1 CFKCGGALRGSYITALGRKYHVEHFTCSVCPTVFGPNDSYYEHEGKIYCHYHY 53

The third LIM domain of Lrg1p, a LIM and RhoGap domain containing protein; The third LIM domain of Lrg1p, a LIM and RhoGap domain containing protein: The members of this family contain three tandem repeats of LIM domains and a Rho-type GTPase activating protein (RhoGap) domain. Lrg1p is a Rho1 GTPase-activating protein required for efficient cell fusion in yeast. Lrg1p-GAP domain strongly and specifically stimulates the GTPase activity of Rho1p, a regulator of beta (1-3)-glucan synthase in vitro. The LIM domain is 50-60 amino acids in size and shares two characteristic zinc finger motifs. The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. LIM domains function as adaptors or scaffolds to support the assembly of multimeric protein.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1959422415  501 CAACKEPIDDECIMLGESRWHLKPphLTCAACQTDLTDTCQEALWSPRIKKVFCNSCA 558
Cdd:cd09393      1 CASCGKSIEDECIKFEDKRWHLKC--FTCSRCHREISSELSDAAFNNKDQRILCSNCS 56

Zinc-binding domain present in Lin-11, Isl-1, Mec-3; Zinc-binding domain family. Some LIM domains bind protein partners via tyrosine-containing motifs. LIM domains are found in many key regulators of developmental pathways.

                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1959422415   125 ICKKCGEPLTG--QFVRALGATYHLECFKCEDCGQIVASKFFpvDAEDGSgqyPLCETD 181
Cdd:smart00132    1 KCAGCGKPIYGteRVLRALGKVWHPECFKCATCGKPLSGDTF--FEKDGK---LYCKDC 54

LIM domain; This family represents two copies of the LIM structural domain.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1959422415  501 CAACKEPIDDECIMLG-ESRWHlkPPHLTCAACQTDLTDTCQealwSPRIKKVFCNSC 557
Cdd:pfam00412    1 CAGCNRPIYDRELVRAlGKVWH--PECFRCAVCGKPLTTGDF----YEKDGKLYCKHD 52

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959422415  860 FGVSLDFLVEKEGTESTHGVGPGALRVPALVDDAVSAMRQMDMSVEGVFRKNGNIRRLKEISEMIDNKYDQV-DLTKETP 938
Cdd:cd04397      1 FGVPLEILVEKFGADSTLGVGPGKLRIPALIDDIISAMRQMDMSVEGVFRKNGNIRRLKELTEEIDKNPTEVpDLSKENP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959422415  939 VQIAALLKKFLREMPDPLLTFKLHNLFVISQKIPDPEKQKRLLHLTCCLLPKAHRDTMEVLFAFLNWTSSFSHVDEDTGS 1018
Cdd:cd04397     81 VQLAALLKKFLRELPDPLLTFKLYRLWISSQKIEDEEERKRVLHLVYCLLPKYHRDTMEVLFSFLKWVSSFSHIDEETGS 160

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1959422415 1019 KMDIHNLATVITPNILYPNTKNS-TVDESFLAIEAVNALITYNDTMCEIPEDL 1070
Cdd:cd04397    161 KMDIHNLATVITPNILYSKTDNPnTGDEYFLAIEAVNYLIENNEEFCEVPDEL 213

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959422415   885 RVPALVDDAVSAMRQMDMSVEGVFRKNGNIRRLKEISEMIDN-KYDQVDLTKETPVQIAALLKKFLREMPDPLLTFKLHN 963
Cdd:smart00324    2 PIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSgPDPDLDLSEYDVHDVAGLLKLFLRELPEPLITYELYE 81

                            90       100       110       120       130       140       150
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1959422415   964 LFVISQKIPDPEKQKRLLHLTCCLLPKAHRDTMEVLFAFLNWTSSFSHVdedtgSKMDIHNLATVITPNILYPNTKNS 1041
Cdd:smart00324   82 EFIEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEE-----NKMTARNLAIVFGPTLLRPPDGEV 154

The first LIM domain of Lrg1p, a LIM and RhoGap domain containing protein; The first LIM domain of Lrg1p, a LIM and RhoGap domain containing protein: The members of this family contain three tandem repeats of LIM domains and a Rho-type GTPase activating protein (RhoGap) domain. Lrg1p is a Rho1 GTPase-activating protein required for efficient cell fusion in yeast. Lrg1p-GAP domain strongly and specifically stimulates the GTPase activity of Rho1p, a regulator of beta (1-3)-glucan synthase in vitro. The LIM domain is 50-60 amino acids in size and shares two characteristic zinc finger motifs. The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. LIM domains function as adaptors or scaffolds to support the assembly of multimeric protein.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1959422415  126 CKKCGEPLTGQFVRALGATYHLECFKCEDCGQIVASKFFPVDAEDGSGQYPLCETDY 182
Cdd:cd09391      1 CAKCGKPITGQFVRALGDVYHLDCFTCHDCGKPVASKFFPVDDPDTSEQVPLCETDY 57

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959422415  859 VFGVSLDFLVEKEGTESthgvgPGaLRVPALVDDAVSAMRQMDMSVEGVFRKNGNIRRLKEISEMIDNKY--DQVDLTKE 936
Cdd:cd04391      1 LFGVPLSTLLERDQKKV-----PG-SKVPLIFQKLINKLEERGLETEGILRIPGSAQRVKFLCQELEAKFyeGTFLWDQV 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959422415  937 TPVQIAALLKKFLREMPDPLLTFKLHNLFVISQKIPDPEKQKRLLHLTCCLLPKAHRDTMEVLFAFLNWTssfshVDEDT 1016
Cdd:cd04391     75 KQHDAASLLKLFIRELPQPLLTVEYLPAFYSVQGLPSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKV-----VDHEE 149

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1959422415 1017 GSKMDIHNLATVITPNILYPNTKNSTVDES-----FLAIEA---VNALITYNDTMCEIPEDLQA 1072
Cdd:cd04391    150 KNKMNLWNVAMIMAPNLFPPRGKHSKDNESlqeevNMAAGCaniMRLLIRYQDLLWTVPSFLIN 213

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959422415  859 VFGVSLDFLVEKEGTESTHgvgpgalrVPALVDDAVSAMRQmDMSVEGVFRKNGNIRRLKEISEMIDNKYDQvdLTKETP 938
Cdd:cd04394      1 VFGVPLHSLPHSTVPEYGN--------VPKFLVDACTFLLD-HLSTEGLFRKSGSVVRQKELKAKLEGGEAC--LSSALP 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959422415  939 VQIAALLKKFLREMPDPLLTFKLHNLFVISQKIPDPEKQKRLLHLTCCLLPKAHRDTMEVLFAFLNWTSsfSHVDEDtgs 1018
Cdd:cd04394     70 CDVAGLLKQFFRELPEPLLPYDLHEALLKAQELPTDEERKSATLLLTCLLPDEHVNTLRYFFSFLYDVA--QRCSEN--- 144

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1959422415 1019 KMDIHNLATVITPNILYPNTKNSTVDESF---LAIEA--VNALITYNDTMCEIPE 1068
Cdd:cd04394    145 KMDSSNLAVIFAPNLFQSEEGGEKMSSSTekrLRLQAavVQTLIDNASNIGIVPD 199

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959422415  860 FGVSLDFLVEKEGTesthgvgpgalrVPALVDDAVSAMRQMDMSVEGVFRKNGNIRRLKEISEMIDNKYDQVDLTKETPV 939
Cdd:cd04377      1 FGVSLSSLTSEDRS------------VPLVLEKLLEHIEMHGLYTEGIYRKSGSANKIKELRQGLDTDPDSVNLEDYPIH 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959422415  940 QIAALLKKFLREMPDPLLTFKLHNLFVISQKIPDPEKQKRLLHLTCCLLPKAHRDTMEVLFAFLNWTSsfshvDEDTGSK 1019
Cdd:cd04377     69 VITSVLKQWLRELPEPLMTFELYENFLRAMELEEKQERVRALYSVLEQLPRANLNTLERLIFHLVRVA-----LQEEVNR 143

                          170
                   ....*....|....*
gi 1959422415 1020 MDIHNLATVITPNIL 1034
Cdd:cd04377    144 MSANALAIVFAPCIL 158

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959422415  860 FGVSLDFLVEKEGtesthgvgpgaLRVPALVDDAVSAMRQMDMSVEGVFRKNGNIRRLKEISEMIDNKYDQVDLTK---- 935
Cdd:cd04398      1 FGVPLEDLILREG-----------DNVPNIVYQCIQAIENFGLNLEGIYRLSGNVSRVNKLKELFDKDPLNVLLISpedy 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959422415  936 ETPVQ-IAALLKKFLREMPDPLLTFKLHNLFVISQKIPDPEKQKRLLHLTCCLLPKAHRDTMEVLFAFLNWTSSFSHVDe 1014
Cdd:cd04398     70 ESDIHsVASLLKLFFRELPEPLLTKALSREFIEAAKIEDESRRRDALHGLINDLPDANYATLRALMFHLARIKEHESVN- 148

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1959422415 1015 dtgsKMDIHNLATVITPNILYPNTKNSTvDESFlAIEAVNALITYNDT 1062
Cdd:cd04398    149 ----RMSVNNLAIIWGPTLMNAAPDNAA-DMSF-QSRVIETLLDNAYQ 190

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959422415  885 RVPALVDDAVSAMRQMDMSVEGVFRKNGNIRRLKEISEMIDNKYDQVDLT----KETPVqIAALLKKFLREMPDPLLTFK 960
Cdd:cd04395     17 YVPLIVEVCCNIVEARGLETVGIYRVPGNNAAISALQEELNRGGFDIDLQdprwRDVNV-VSSLLKSFFRKLPEPLFTNE 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959422415  961 LHNLFVISQKIPDPEKQ----KRLLHltccLLPKAHRDTMEVLFAFLNWTSSFSHVDedtgsKMDIHNLATVITPNILYP 1036
Cdd:cd04395     96 LYPDFIEANRIEDPVERlkelRRLIH----SLPDHHYETLKHLIRHLKTVADNSEVN-----KMEPRNLAIVFGPTLVRT 166

                          170       180
                   ....*....|....*....|....*....
gi 1959422415 1037 NTKNST--VDESFLAIEAVNALITYNDTM 1063
Cdd:cd04395    167 SDDNMEtmVTHMPDQCKIVETLIQHYDWF 195

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959422415  859 VFGVSLDFLVEKEGTEsthgvgpgalrVPALVDDAVSAMRQMDMSVEGVFRKNGNIRRLKEISEMIDNKYDQVDLTKETP 938
Cdd:cd04375      4 VFGVPLLVNLQRTGQP-----------LPRSIQQAMRWLRNNALDQVGLFRKSGVKSRIQKLRSMIESSTDNVNYDGQQA 72

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959422415  939 VQIAALLKKFLREMPDPLLTFKLHNLFV-ISQKIPdPEKQKRLLHLTCCLLPKAHRDTMEVLFAFLNWTSSFSHVDEDTG 1017
Cdd:cd04375     73 YDVADMLKQYFRDLPEPLLTNKLSETFIaIFQYVP-KEQRLEAVQCAILLLPDENREVLQTLLYFLSDVAANSQENQMTA 151

                          170       180
                   ....*....|....*....|...
gi 1959422415 1018 SkmdihNLATVITPNILYPNTKN 1040
Cdd:cd04375    152 T-----NLAVCLAPSLFHLNTSR 169

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959422415  859 VFGVSLDFLvEKEGtESTHGVgpgalrvPALVDDAVSAMRQMDMSVEGVFRKNGNIRRLKEISEMIDNKYDqVDLTKETP 938
Cdd:cd04393      2 VFGVPLQEL-QQAG-QPENGV-------PAVVRHIVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLDSGEE-VDLSKEAD 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959422415  939 V-QIAALLKKFLREMPDPLLTFKLHNLFV-ISQKIPDPEKQKRLLHLTCCLLPKAHRDTMEVLFAFLNWTSSFSHVDedt 1016
Cdd:cd04393     72 VcSAASLLRLFLQELPEGLIPASLQIRLMqLYQDYNGEDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHEN--- 148

                          170
                   ....*....|....*....
gi 1959422415 1017 gsKMDIHNLATVITPNILY 1035
Cdd:cd04393    149 --RMTAENLAAVFGPDVFH 165

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959422415  860 FGVSLDFLVEKEGTesthgvgpgalRVPALVDDAVSAMRQMDMSVEGVFRKNGNIRRLKEISEMIDNKYDQVDLTKETPV 939
Cdd:cd04372      1 YGCDLTTLVKAHNT-----------QRPMVVDMCIREIEARGLQSEGLYRVSGFAEEIEDVKMAFDRDGEKADISATVYP 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959422415  940 Q---IAALLKKFLREMPDPLLTFKLHNLFVISQKIPDPEKQKRLLHLTCCLLPKAHRDTMEVLFAFLNWTSSFSHVDedt 1016
Cdd:cd04372     70 DinvITGALKLYFRDLPIPVITYDTYPKFIDAAKISNPDERLEAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKDN--- 146

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 1959422415 1017 gsKMDIHNLATVITPNILYPNTKNS--TVDESFLAIEAVNALITYNDTM 1063
Cdd:cd04372    147 --KMNAENLGIVFGPTLMRPPEDSAltTLNDMRYQILIVQLLITNEDVL 193

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959422415  886 VPALVDDAVSAMRQMDMSVEGVFRKNGNIRRLKEISEMIDNKYDQVDLT--KETPVQIAALLKKFLREMPDPLLTFKLHN 963
Cdd:cd04385     15 IPVIVDKCIDFITQHGLMSEGIYRKNGKNSSVKKLLEAFRKDARSVQLRegEYTVHDVADVLKRFLRDLPDPLLTSELHA 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959422415  964 LFVISQKIPD-PEKQKRLLHLTCClLPKAHRDTMEVLFAFLNWTSSFShvDEDtgsKMDIHNLATVITPNILYPNTKNST 1042
Cdd:cd04385     95 EWIEAAELENkDERIARYKELIRR-LPPINRATLKVLIGHLYRVQKHS--DEN---QMSVHNLALVFGPTLFQTDEHSVG 168

                          170
                   ....*....|....*..
gi 1959422415 1043 VDESflAIEAVNALITY 1059
Cdd:cd04385    169 QTSH--EVKVIEDLIDN 183

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959422415  882 GALRVPALVDDAVSAMRQMDMSVEGVFRKNGNIRRLKEISEMIDNKyDQVDLTKETPVQ-IAALLKKFLREMPDPLLTFK 960
Cdd:cd04390     18 GPRLVPILVEQCVDFIREHGLKEEGLFRLPGQANLVKQLQDAFDAG-ERPSFDSDTDVHtVASLLKLYLRELPEPVIPWA 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959422415  961 LHNLFVISQKIPDPEKQKRLLHLT--CCLLPKAHRDTMEVLFAFLNWTSSFSHVDedtgsKMDIHNLATVITPNILYPNT 1038
Cdd:cd04390     97 QYEDFLSCAQLLSKDEEKGLGELMkqVSILPKVNYNLLSYICRFLDEVQSNSSVN-----KMSVQNLATVFGPNILRPKV 171

                   ..
gi 1959422415 1039 KN 1040
Cdd:cd04390    172 ED 173

LIM is a small protein-protein interaction domain, containing two zinc fingers; LIM domains are identified in a diverse group of proteins with wide variety of biological functions, including gene expression regulation, cell fate determination, cytoskeleton organization, tumor formation and development. LIM domains function as adaptors or scaffolds to support the assembly of multimeric protein complexes. They perform their functions through interactions with other protein partners. LIM domains are 50-60 amino acids in size and share two characteristic highly conserved zinc finger motifs. The two zinc fingers contain eight conserved residues, mostly cysteines and histidines, which coordinately bond to two zinc atoms. The consensus sequence of LIM domain has been defined as C-x(2)-C-x(16,23)-H-x(2)-[CH]-x(2)-C-x(2)-C-x(16,21)-C-x(2,3)-[CHD] (where X denotes any amino acid).

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1959422415  190 CHECGGALRGSYI-TALDHKYHIEHFTCSVCPTVFGaQDSYYEHEGRVYCHFHY 242
Cdd:cd08368      1 CAGCGKPIEGRELlRALGKKWHPECFKCAECGKPLG-GDSFYEKDGKPYCEKCY 53

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959422415  860 FGVSLDFLVEKEGTesthgvgpgalrVPALVDDAVSAMRQMDMSVEGVFRKNGNIRRLKEISEMIDNKYDQVDLTKETPV 939
Cdd:cd04406      1 FGVELSRLTSEDRS------------VPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDANSVNLDDYNIH 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959422415  940 QIAALLKKFLREMPDPLLTFKLHNLFVISQKIPDPEKQKRLLHLTCCLLPKAHRDTMEVLFAFLNWTSsfshVDEDTgSK 1019
Cdd:cd04406     69 VIASVFKQWLRDLPNPLMTFELYEEFLRAMGLQERRETVRGVYSVIDQLSRTHLNTLERLIFHLVRIA----LQEET-NR 143

                          170       180
                   ....*....|....*....|..
gi 1959422415 1020 MDIHNLATVITPNILY-PNTKN 1040
Cdd:cd04406    144 MSANALAIVFAPCILRcPDTTD 165

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959422415  860 FGVSLDFLVEKEgtesthgvgPGALRVPALVDDAVSAMRQMDMSVEGVFRKNGNIRRLKEISEMIDNKYDQVDLTKE--- 936
Cdd:cd04379      1 FGVPLSRLVERE---------GESRDVPIVLQKCVQEIERRGLDVIGLYRLCGSAAKKKELRDAFERNSAAVELSEElyp 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1959422415  937 -TPVqIAALLKKFLREMPDPLLTFKLHN--LFVISQKIPDPEKQKR---LLHLTCCllPKAHRDTMEVLFAFLNWTSSFS 1010
Cdd:cd04379     72 dINV-ITGVLKDYLRELPEPLITPQLYEmvLEALAVALPNDVQTNThltLSIIDCL--PLSAKATLLLLLDHLSLVLSNS 148