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Conserved domains on  [gi|195934722|ref|YP_002120657|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Meles meles]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-177 1.13e-84

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 246.64  E-value: 1.13e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195934722   1 MMTYIVFILSVVFVVSFVGFSSKPSPIYGGLALIISGAVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEQYP 80
Cdd:MTH00109   1 MMMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195934722  81 EVWVSNKAVLGAFVVGLLSELLMACYILKGDdvEVEVVLKFNGAGDWVIYDTGDSGFFSEEAMGIAALYSYGTWLVIVTG 160
Cdd:MTH00109  81 ETWVSNKVVLGALLLGLLMELLLVLYVLKDD--EVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTG 158

                        170
                 ....*....|....*..
gi 195934722 161 WSLLIGVLVIMEVTRGN 177
Cdd:MTH00109 159 WSLFIGVFVIIEITRGN 175
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-177 1.13e-84

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 246.64  E-value: 1.13e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195934722   1 MMTYIVFILSVVFVVSFVGFSSKPSPIYGGLALIISGAVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEQYP 80
Cdd:MTH00109   1 MMMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195934722  81 EVWVSNKAVLGAFVVGLLSELLMACYILKGDdvEVEVVLKFNGAGDWVIYDTGDSGFFSEEAMGIAALYSYGTWLVIVTG 160
Cdd:MTH00109  81 ETWVSNKVVLGALLLGLLMELLLVLYVLKDD--EVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTG 158

                        170
                 ....*....|....*..
gi 195934722 161 WSLLIGVLVIMEVTRGN 177
Cdd:MTH00109 159 WSLFIGVFVIIEITRGN 175
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
24-172 2.14e-11

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 58.67  E-value: 2.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195934722   24 PSPIYGGLALIISGAVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEQYPEVWVSNKAVLGAFVVGLLsellm 103
Cdd:pfam00499   7 RNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLL----- 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 195934722  104 acyilkgddVEVEVVLKFNGAGDWVIYDTGDSGFFSEEAMGIaALYSYGTWLVIVTGWSLLIGVLVIME 172
Cdd:pfam00499  82 ---------LLALLLLVLLSASLTPAAAAAAPDVGNIEAIGE-LLFTDYLLPFELASVLLLVALVGAIV 140
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-177 1.13e-84

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 246.64  E-value: 1.13e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195934722   1 MMTYIVFILSVVFVVSFVGFSSKPSPIYGGLALIISGAVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEQYP 80
Cdd:MTH00109   1 MMMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195934722  81 EVWVSNKAVLGAFVVGLLSELLMACYILKGDdvEVEVVLKFNGAGDWVIYDTGDSGFFSEEAMGIAALYSYGTWLVIVTG 160
Cdd:MTH00109  81 ETWVSNKVVLGALLLGLLMELLLVLYVLKDD--EVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTG 158

                        170
                 ....*....|....*..
gi 195934722 161 WSLLIGVLVIMEVTRGN 177
Cdd:MTH00109 159 WSLFIGVFVIIEITRGN 175
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 2-176 1.47e-29

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 106.76  E-value: 1.47e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195934722   2 MTYIVFILSVVFVVSFVGFSSKPSPIYGGLALIISGAVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEQYPE 81
Cdd:MTH00138   1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195934722  82 VWVSNkAVLGAFVVGLLSELLMACYILKGddvevevvlkfNGAGDWVI-YDTGDSGFFSEEAMGIAALYSYGTWLVIVTG 160
Cdd:MTH00138  81 SWGSW-SVLGYVVGYLVGVVLAAGLFWGG-----------WYEGSWVVvDELKEFSVLRGDVGGVALMYSSGGGMLVICA 148

                        170
                 ....*....|....*.
gi 195934722 161 WSLLIGVLVIMEVTRG 176
Cdd:MTH00138 149 WVLLLTLFVVLELTRG 164
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 2-176 1.92e-25

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 96.07  E-value: 1.92e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195934722   2 MTYIVFILSVVFVVSFVGFSSKPSPIYGGLALIISGAVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEQYPE 81
Cdd:MTH00065   1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195934722  82 VWvSNKAVLGAFVVGLLseLLMACYILKGDDVEVEVvlkfngagdWVIYDTGDSGFFSEEAMGIAALYSYGTWLVIVTGW 161
Cdd:MTH00065  81 AW-GSWSVLVYVLFYLL--LLIVGYILFGCNFSLEF---------LFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGW 148

                        170
                 ....*....|....*
gi 195934722 162 SLLIGVLVIMEVTRG 176
Cdd:MTH00065 149 VLLLTLFVVLEVTRG 163
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 2-176 3.78e-22

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 87.50  E-value: 3.78e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195934722   2 MTYIVFILSVVFVVSFVGFSSKPSPIYGGLALIISGAVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEQYPE 81
Cdd:MTH00115   1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195934722  82 VWVSNKAVLGAFVVGLLSELLMACYILKGDDVEVEVVLKFNGAGDWVIYDTGdsgffseeamGIAALYSYGTWLVIVTGW 161
Cdd:MTH00115  81 AWGDWGVVGYVVGFVLVVVVVGVVVGGLWGMEGVGVVTVDSGGLFVVRLDFS----------GVSLFYSSGGGGLLVCGW 150

                        170
                 ....*....|....*
gi 195934722 162 SLLIGVLVIMEVTRG 176
Cdd:MTH00115 151 GLLLTLFVVLELVRG 165
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 2-176 3.79e-16

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 71.56  E-value: 3.79e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195934722   2 MTYIVFILSVVFVVSFVGFSSKPSPIYGGLALIISGAVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEQYPE 81
Cdd:MTH00214   1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195934722  82 VWVSNKAVLGAFVVGLLSELLMACYILkgddvevevvlkfngaGDWVIYDTGDSGFFSEEAMGIAALYSYGTWLVIVTGW 161
Cdd:MTH00214  81 SWGGWSVLLFFLFYLLGLGFVGFYFYG----------------GWEMLSWMGVDEANNLDLSGVSDLYSRGFFLLLLGGV 144

                        170
                 ....*....|....*
gi 195934722 162 SLLIGVLVIMEVTRG 176
Cdd:MTH00214 145 VLFLVLFVVLELVRG 159
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 1-177 1.64e-12

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 61.85  E-value: 1.64e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195934722   1 MMTYIVFILSVVFVVSFVGFSskpSPIYGGLALIISGAVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEQYP 80
Cdd:MTH00045   1 MVFYLFLILMLFGSTLVFYSL---SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195934722  81 EVWVSNKAVLGAFVVGLLsellmacyilkgddveveVVLKFNGAGDWVIYDTGDSGFFSEeaMGIAALYSYGTWLVIVTG 160
Cdd:MTH00045  78 SVSNLGEVLVLSLLLSLW------------------VFISFDNFLELSNNNWSLVSLSDL--VGSSELYNSGGLYLLLGG 137

                        170
                 ....*....|....*..
gi 195934722 161 WSLLIGVLVIMEVTRGN 177
Cdd:MTH00045 138 FILLVALVVALVISFGH 154
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
24-172 2.14e-11

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 58.67  E-value: 2.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195934722   24 PSPIYGGLALIISGAVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEQYPEVWVSNKAVLGAFVVGLLsellm 103
Cdd:pfam00499   7 RNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLLLAEEEPEKLRSGLPLAALLLGLL----- 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 195934722  104 acyilkgddVEVEVVLKFNGAGDWVIYDTGDSGFFSEEAMGIaALYSYGTWLVIVTGWSLLIGVLVIME 172
Cdd:pfam00499  82 ---------LLALLLLVLLSASLTPAAAAAAPDVGNIEAIGE-LLFTDYLLPFELASVLLLVALVGAIV 140
ND6 MTH00152
NADH dehydrogenase subunit 6; Provisional
 25-75 7.37e-04

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214437  Cd Length: 163  Bit Score: 38.33  E-value: 7.37e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 195934722  25 SPIYGGLALIISGAVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMA 75
Cdd:MTH00152  22 QPLSLGLVLLLLSLFVCVEIGLTLSSWYGYLLFLVYVGGLLVMFAYVVSLS 72
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 25-75 1.66e-03

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 37.29  E-value: 1.66e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 195934722  25 SPIYGGLALIISGAVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMA 75
Cdd:MTH00212  22 HPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALS 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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