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Conserved domains on  [gi|1958760264|ref|XP_038960356|]
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probable cytosolic iron-sulfur protein assembly protein CIAO1 isoform X1 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-221 2.34e-61

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 193.71  E-value: 2.34e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760264  17 SRCWFLAWNPTGTLLASCGGDRKIRIWGTEGDSwiCKSVLsEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDdfE 96
Cdd:cd00200    10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTL-KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG--E 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760264  97 CVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVdeeDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKL 176
Cdd:cd00200    85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV---ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1958760264 177 YqeEGDDWVCCATLEGHESTVWSIAFDPSGQRLASCSDDRTVRIW 221
Cdd:cd00200   162 W--DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-221 2.34e-61

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 193.71  E-value: 2.34e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760264  17 SRCWFLAWNPTGTLLASCGGDRKIRIWGTEGDSwiCKSVLsEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDdfE 96
Cdd:cd00200    10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTL-KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG--E 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760264  97 CVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVdeeDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKL 176
Cdd:cd00200    85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV---ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1958760264 177 YqeEGDDWVCCATLEGHESTVWSIAFDPSGQRLASCSDDRTVRIW 221
Cdd:cd00200   162 W--DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
20-222 2.01e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 187.04  E-value: 2.01e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760264  20 WFLAWNPTGTLLASCGGDRKIRIWGTEGDSWICksvLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWkkNQDDFECVT 99
Cdd:COG2319   208 RSVAFSPDGKLLASGSADGTVRLWDLATGKLLR---TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW--DLATGELLR 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760264 100 TLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEdeyECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYqe 179
Cdd:COG2319   283 TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG---KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW-- 357

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1958760264 180 EGDDWVCCATLEGHESTVWSIAFDPSGQRLASCSDDRTVRIWR 222
Cdd:COG2319   358 DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 183-221 2.76e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.86  E-value: 2.76e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1958760264  183 DWVCCATLEGHESTVWSIAFDPSGQRLASCSDDRTVRIW 221
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
184-221 1.03e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.35  E-value: 1.03e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1958760264 184 WVCCATLEGHESTVWSIAFDPSGQRLASCSDDRTVRIW 221
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 22-123 2.56e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 47.64  E-value: 2.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760264  22 LAWNPT-GTLLASCGGDRKIRIWGTEGDSWICKSV-----LSEGHQRTVRKVAWSPCGNY-LASASFDATTCIW--KKNQ 92
Cdd:PTZ00420   80 LQFNPCfSEILASGSEDLTIRVWEIPHNDESVKEIkdpqcILKGHKKKISIIDWNPMNYYiMCSSGFDSFVNIWdiENEK 159

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1958760264  93 DDFECVTTlegheNEVKSVAWAPSGNLLA-TC 123
Cdd:PTZ00420  160 RAFQINMP-----KKLSSLKWNIKGNLLSgTC 186
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-221 2.34e-61

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 193.71  E-value: 2.34e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760264  17 SRCWFLAWNPTGTLLASCGGDRKIRIWGTEGDSwiCKSVLsEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDdfE 96
Cdd:cd00200    10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTL-KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG--E 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760264  97 CVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVdeeDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKL 176
Cdd:cd00200    85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV---ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1958760264 177 YqeEGDDWVCCATLEGHESTVWSIAFDPSGQRLASCSDDRTVRIW 221
Cdd:cd00200   162 W--DLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
20-222 2.01e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 187.04  E-value: 2.01e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760264  20 WFLAWNPTGTLLASCGGDRKIRIWGTEGDSWICksvLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWkkNQDDFECVT 99
Cdd:COG2319   208 RSVAFSPDGKLLASGSADGTVRLWDLATGKLLR---TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW--DLATGELLR 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760264 100 TLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEdeyECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYqe 179
Cdd:COG2319   283 TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG---KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW-- 357

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1958760264 180 EGDDWVCCATLEGHESTVWSIAFDPSGQRLASCSDDRTVRIWR 222
Cdd:COG2319   358 DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 22-222 3.09e-53

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 172.90  E-value: 3.09e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760264  22 LAWNPTGTLLASCGGDRKIRIWGTEGDSwiCKSVLsEGHQRTVRKVAWSPCGNYLASASFDATTCIWkkNQDDFECVTTL 101
Cdd:cd00200    99 VAFSPDGRILSSSSRDKTIKVWDVETGK--CLTTL-RGHTDWVNSVAFSPDGTFVASSSQDGTIKLW--DLRTGKCVATL 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760264 102 EGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDeyeCVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYQeeG 181
Cdd:cd00200   174 TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK---CLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWD--L 248

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1958760264 182 DDWVCCATLEGHESTVWSIAFDPSGQRLASCSDDRTVRIWR 222
Cdd:cd00200   249 RTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
10-221 5.32e-53

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 175.87  E-value: 5.32e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760264  10 RVPAHPDSRCWFLAWNPTGTLLASCGGDRKIRIWGTEgdSWICKSVLSeGHQRTVRKVAWSPCGNYLASASFDATTCIWk 89
Cdd:COG2319   114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--TGKLLRTLT-GHSGAVTSVAFSPDGKLLASGSDDGTVRLW- 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760264  90 kNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEdeyECVSVLNSHTQDVKHVVWHPSQELLASAS 169
Cdd:COG2319   190 -DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG---KLLRTLTGHSGSVRSVAFSPDGRLLASGS 265

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1958760264 170 YDDTVKLYQEEGDDWVccATLEGHESTVWSIAFDPSGQRLASCSDDRTVRIW 221
Cdd:COG2319   266 ADGTVRLWDLATGELL--RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
10-222 1.63e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 174.33  E-value: 1.63e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760264  10 RVPAHPDSRCWFLAWNPTGTLLASCGGDRKIRIWGTEGDSWIcksVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWk 89
Cdd:COG2319    72 ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLL---RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW- 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760264  90 kNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEdeyECVSVLNSHTQDVKHVVWHPSQELLASAS 169
Cdd:COG2319   148 -DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG---KLLRTLTGHTGAVRSVAFSPDGKLLASGS 223

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958760264 170 YDDTVKLYQEEGDDWVccATLEGHESTVWSIAFDPSGQRLASCSDDRTVRIWR 222
Cdd:COG2319   224 ADGTVRLWDLATGKLL--RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274
WD40 COG2319
WD40 repeat [General function prediction only];
23-222 2.98e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.48  E-value: 2.98e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760264  23 AWNPTGTLLASCGGDRKIRIWGTEGDSWIcksVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWkkNQDDFECVTTLE 102
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALL---LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLL--DAAAGALLATLL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760264 103 GHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEdeyECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYqeEGD 182
Cdd:COG2319    76 GHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG---LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW--DLA 150

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1958760264 183 DWVCCATLEGHESTVWSIAFDPSGQRLASCSDDRTVRIWR 222
Cdd:COG2319   151 TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 97-221 2.54e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.58  E-value: 2.54e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760264  97 CVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEdeyECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKL 176
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG---ELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRL 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1958760264 177 YQEEGDDwvCCATLEGHESTVWSIAFDPSGQRLASCSDDRTVRIW 221
Cdd:cd00200    78 WDLETGE--CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVW 120
WD40 COG2319
WD40 repeat [General function prediction only];
10-135 5.62e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.92  E-value: 5.62e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760264  10 RVPAHPDSRCWFLAWNPTGTLLASCGGDRKIRIWgtEGDSWICKSVLSeGHQRTVRKVAWSPCGNYLASASFDATTCIWk 89
Cdd:COG2319   282 RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW--DLATGKLLRTLT-GHTGAVRSVAFSPDGKTLASGSDDGTVRLW- 357

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1958760264  90 kNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVD 135
Cdd:COG2319   358 -DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-133 5.69e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 99.33  E-value: 5.69e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760264  16 DSRCWFLAWNPTGTLLASCGGDRKIRIWGTEGDSWICksvLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKnqDDF 95
Cdd:cd00200   177 TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG---TLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDL--RTG 251

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1958760264  96 ECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE 133
Cdd:cd00200   252 ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 183-221 2.76e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.86  E-value: 2.76e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1958760264  183 DWVCCATLEGHESTVWSIAFDPSGQRLASCSDDRTVRIW 221
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
184-221 1.03e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.35  E-value: 1.03e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1958760264 184 WVCCATLEGHESTVWSIAFDPSGQRLASCSDDRTVRIW 221
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 94-133 2.00e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.54  E-value: 2.00e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1958760264   94 DFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE 133
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
95-133 2.36e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.50  E-value: 2.36e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1958760264  95 FECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE 133
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 186-222 1.19e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.10  E-value: 1.19e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1958760264 186 CCATLEGHESTVWSIAFDPSGQRLASCSDDRTVRIWR 222
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWD 37
PTZ00420 PTZ00420
coronin; Provisional
 22-123 2.56e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 47.64  E-value: 2.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760264  22 LAWNPT-GTLLASCGGDRKIRIWGTEGDSWICKSV-----LSEGHQRTVRKVAWSPCGNY-LASASFDATTCIW--KKNQ 92
Cdd:PTZ00420   80 LQFNPCfSEILASGSEDLTIRVWEIPHNDESVKEIkdpqcILKGHKKKISIIDWNPMNYYiMCSSGFDSFVNIWdiENEK 159

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1958760264  93 DDFECVTTlegheNEVKSVAWAPSGNLLA-TC 123
Cdd:PTZ00420  160 RAFQINMP-----KKLSSLKWNIKGNLLSgTC 186
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 141-177 3.87e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 3.87e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1958760264  141 ECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLY 177
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PTZ00420 PTZ00420
coronin; Provisional
 98-182 4.16e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.87  E-value: 4.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760264  98 VTTLEGHENEVKSVAWAPS-GNLLATCSRDKSVWVWEVDEEDEY-------ECvsVLNSHTQDVKHVVWHP-SQELLASA 168
Cdd:PTZ00420   67 VIKLKGHTSSILDLQFNPCfSEILASGSEDLTIRVWEIPHNDESvkeikdpQC--ILKGHKKKISIIDWNPmNYYIMCSS 144

                          90
                  ....*....|....
gi 1958760264 169 SYDDTVKLYQEEGD 182
Cdd:PTZ00420  145 GFDSFVNIWDIENE 158
WD40 pfam00400
WD domain, G-beta repeat;
141-177 3.57e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 3.57e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1958760264 141 ECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLY 177
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 49-89 3.61e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 3.61e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1958760264   49 SWICKSVLsEGHQRTVRKVAWSPCGNYLASASFDATTCIWK 89
Cdd:smart00320   1 SGELLKTL-KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 21-165 6.97e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 43.34  E-value: 6.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760264  21 FLAWNPTGTLLAScgGDRKIRIWG--TEGDSWICKSVLSE--GHQRTVRKVAWSPCG-NYLASASFDATTCIWKKNQDdf 95
Cdd:PTZ00421   83 FNPFDPQKLFTAS--EDGTIMGWGipEEGLTQNISDPIVHlqGHTKKVGIVSFHPSAmNVLASAGADMVVNVWDVERG-- 158

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760264  96 ECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVweVDEEDEYECVSVLNSHTQDVKHVVWHPSQELL 165
Cdd:PTZ00421  159 KAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNI--IDPRDGTIVSSVEAHASAKSQRCLWAKRKDLI 226
WD40 pfam00400
WD domain, G-beta repeat;
58-88 1.57e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 1.57e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1958760264  58 EGHQRTVRKVAWSPCGNYLASASFDATTCIW 88
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 23-135 2.13e-04

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 40.72  E-value: 2.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760264  23 AWNPTGTLLASCGG--DRKIRIWGTEGDSwICKsvLSEGHQRTVRkvaWSPCGNYLASASF---DATTCIWkkNQDDFEC 97
Cdd:pfam08662  66 AWSPNGKEFAVIYGymPAKVSFFDLKGNV-IHS--FGEQPRNTIF---WSPFGRLVLLAGFgnlAGDIEFW--DVVNKKK 137

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1958760264  98 VTTLEgHENEVkSVAWAPSGNLLATCSR------DKSVWVWEVD 135
Cdd:pfam08662 138 IATAE-ASNAT-LCEWSPDGRYFLTATTaprlrvDNGFKIWHYN 179
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 106-233 2.23e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.00  E-value: 2.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958760264 106 NEVKSVAWAPSGNLLATCSRDKSVWVWEV-----DEEDEYECVSVLNSHTQdVKHVVWHPS-QELLASASYDDTVKLYQE 179
Cdd:PLN00181  484 NLVCAIGFDRDGEFFATAGVNKKIKIFECesiikDGRDIHYPVVELASRSK-LSGICWNSYiKSQVASSNFEGVVQVWDV 562

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958760264 180 EGDDWVccATLEGHESTVWSIAF---DPSgqRLASCSDDRTVRIWrqylpGNEQGVS 233
Cdd:PLN00181  563 ARSQLV--TEMKEHEKRVWSIDYssaDPT--LLASGSDDGSVKLW-----SINQGVS 610
PTZ00420 PTZ00420
coronin; Provisional
 190-232 7.08e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.32  E-value: 7.08e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1958760264 190 LEGHESTVWSIAFDPS-GQRLASCSDDRTVRIWRqyLPGNEQGV 232
Cdd:PTZ00420   70 LKGHTSSILDLQFNPCfSEILASGSEDLTIRVWE--IPHNDESV 111
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 14-43 7.66e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 7.66e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1958760264   14 HPDSRCWFLAWNPTGTLLASCGGDRKIRIW 43
Cdd:smart00320  10 GHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
16-43 4.66e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.86  E-value: 4.66e-03
                          10        20
                  ....*....|....*....|....*...
gi 1958760264  16 DSRCWFLAWNPTGTLLASCGGDRKIRIW 43
Cdd:pfam00400  11 TGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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