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Conserved domains on  [gi|1958759677|ref|XP_038960124|]
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solute carrier organic anion transporter family member 4A1 isoform X2 [Rattus norvegicus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
101-484 0e+00

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17462:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 427  Bit Score: 550.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 101 PKGFLFFLCAASFLQGMTVNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGALVLG 180
Cdd:cd17462     1 PKGVLFFLCAASFLQGMTVNGFINTVITSIERRFDLRSYQSGLIASSYDIAACLCLTFVSYFGGSGHKPRWLGWGVLIMG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 181 IGSLVFALPHFTagryeveiddeglgtetgtcltnqsqveckdrasglssyrlIFMLGQLLHGVGATPLYTLGVTYLDEN 260
Cdd:cd17462    81 LGSLVFALPHFT-----------------------------------------VFMLGQFLHGIGATPLYTLGVTYLDEN 119
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 261 VKSSYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYTEVGQRTELTTDSPLWVGAWWIGFLGAGIAAFLIAIPILGYPRQL 340
Cdd:cd17462   120 VKSNYSPVYIGIFYTAAIVGPAAGYLLGGFFLNIYTEIGRQTELTPENPLWVGAWWIGFLGAGAAALLIALPILGYPRQL 199
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 341 PGsqryvvmraaetqqlkdhsrdnpafgktvrdlplsvwiLLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSA 420
Cdd:cd17462   200 PG--------------------------------------LLKNPTFIFLCLAGATEATLIAGMSTFGPKFLESQFSLSA 241
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958759677 421 SEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFCLFCTLTSLLAFFVFLMHCPNVHMA 484
Cdd:cd17462   242 SEAATLFGYLVVPAGGGGTFLGGFIVNKLKLRCSGIIKFCLICTVVSLLAIFIFSLHCPNVPMA 305
 
Name Accession Description Interval E-value
MFS_SLCO4A_OATP4A cd17462
Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of ...
101-484 0e+00

Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4A (SLCO4A), also called Organic anion-transporting polypeptide 4A (OATP4A), subfamily has one mammalian member, OATP4A1 (encoded by SLCO4A1). It is ubiquitously expressed and it mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4A1 is the most abundantly expressed transporter colorectal cancer (CRC) and its role in the transport of estrone sulfate, which is used in hormone replacement therapy (HRT), affects the outcome of the treatment. The SLCO4A/OATP4A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341020 [Multi-domain]  Cd Length: 427  Bit Score: 550.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 101 PKGFLFFLCAASFLQGMTVNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGALVLG 180
Cdd:cd17462     1 PKGVLFFLCAASFLQGMTVNGFINTVITSIERRFDLRSYQSGLIASSYDIAACLCLTFVSYFGGSGHKPRWLGWGVLIMG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 181 IGSLVFALPHFTagryeveiddeglgtetgtcltnqsqveckdrasglssyrlIFMLGQLLHGVGATPLYTLGVTYLDEN 260
Cdd:cd17462    81 LGSLVFALPHFT-----------------------------------------VFMLGQFLHGIGATPLYTLGVTYLDEN 119
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 261 VKSSYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYTEVGQRTELTTDSPLWVGAWWIGFLGAGIAAFLIAIPILGYPRQL 340
Cdd:cd17462   120 VKSNYSPVYIGIFYTAAIVGPAAGYLLGGFFLNIYTEIGRQTELTPENPLWVGAWWIGFLGAGAAALLIALPILGYPRQL 199
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 341 PGsqryvvmraaetqqlkdhsrdnpafgktvrdlplsvwiLLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSA 420
Cdd:cd17462   200 PG--------------------------------------LLKNPTFIFLCLAGATEATLIAGMSTFGPKFLESQFSLSA 241
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958759677 421 SEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFCLFCTLTSLLAFFVFLMHCPNVHMA 484
Cdd:cd17462   242 SEAATLFGYLVVPAGGGGTFLGGFIVNKLKLRCSGIIKFCLICTVVSLLAIFIFSLHCPNVPMA 305
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
103-484 6.36e-137

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 405.05  E-value: 6.36e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 103 GFLFFLCAASFLQGMtVNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGALVLGIG 182
Cdd:pfam03137   1 FFLVFLSLLGLAQAL-VSGYFNSSITTIEKRFGLPSSLSGLISSSYDIGNLLLIVFVSYFGGKGHRPRWIGVGALLMGLG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 183 SLVFALPHFTAgryeveiddeglgtetgtcltnqsqveckdrasglssyrliFMLGQLLHGVGATPLYTLGVTYLDENVK 262
Cdd:pfam03137  80 SLLFALPHFLS-----------------------------------------FFLGQLLLGIGGTPIYTLGISYIDDNVK 118
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 263 SSYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYTEVGQRT-ELTTDSPLWVGAWWIGFLGAGIAAFLIAIPILGYPRQLP 341
Cdd:pfam03137 119 KKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVDIGKVSiTLTPKDPRWVGAWWLGFLIAGLLLLLTAIPFFFFPKSLP 198
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 342 GSQRYVVMRAAETQQL----KDHSRDNPAFGKTVRDLPLSVWILLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFS 417
Cdd:pfam03137 199 GAAKRRAKKKKEPHSQdiadLKKTKSLKKLGPSLKDFPKALKRLLKNPVYMLLTLASVFEFLLIAGYATFLPKYIETQFG 278
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958759677 418 LSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFCLFCTLTSLLAFFVFL-MHCPNVHMA 484
Cdd:pfam03137 279 LSASTANLLTGVVAIPGAALGILLGGLIIKKFKLSAKGLAKFNVITSLVSLLLSLLLFfLGCPNSPVA 346
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
89-484 4.02e-97

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 306.27  E-value: 4.02e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677  89 SFTPKCLQVFNTPKGFLFFLCAASFLQGMTVNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHK 168
Cdd:TIGR00805  18 KPRPRCLQSLFSKIKMFSLLLTCARLQGLLVNGLVNSMLTSIERRFKIPTSRSGFINGSYEIGNLLLIIFVSYFGTKLHR 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 169 PRWLGWGALVLGIGSLVFALPHFTAGRYEVEIDDEGLGTETG----TCLTNQSQV--------ECKDRASglSSYRLIFM 236
Cdd:TIGR00805  98 PIVIGAGCAIMGLGSLLSSLPHFLMGRYSYSTTVSSTGNLSSansfLCMENLTQTlrptqdpsECQKQHK--SLMWLLFL 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 237 LGQLLHGVGATPLYTLGVTYLDENVKSSYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYTEVG----QRTELTTDSPLWV 312
Cdd:TIGR00805 176 VSNILRGIGATPIFPLGISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYVDTGsvntEDLIITPTDPRWI 255
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 313 GAWWIGFLGAGIAAFLIAIPILGYPRQLPGSQRYVVMRAAETQQLKDH-SRDNPAFGKTVRDLPLSVWILLRNPTFILLC 391
Cdd:TIGR00805 256 GAWWIGFLVCGFVALLTSIPLFFFPKTLPKEGKRVNVDVHEAEKLEKSrGEDRKKNSGITKDFPKFIKRLLCNKIYMLVI 335
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 392 LAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRF-CLFCTLTSLLA 470
Cdd:TIGR00805 336 LAQVIDVLAFNGYITFLPKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKAAYFaICLSTLEYLLY 415
                         410
                  ....*....|....
gi 1958759677 471 FFVFLMHCPNVHMA 484
Cdd:TIGR00805 416 SPKFLITCESAPVA 429
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
100-428 5.94e-10

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 60.76  E-value: 5.94e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 100 TPKGFLFFLCAASFLQGMTvNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGALVL 179
Cdd:COG2814     7 RRWLALLALALGAFLSGLG-IGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 180 GIGSLVFAL-PHFTagryeveiddeglgtetgtcltnqsqveckdrasglssyrlIFMLGQLLHGVGATPLYTLGVTYLD 258
Cdd:COG2814    86 ALGSLLCALaPSLW-----------------------------------------LLLAARFLQGLGAGALFPAALALIA 124
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 259 ENVKSSYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYtevgqrtelttdsplwvgAWWIGFLGAGIAAFLIAIPILgypR 338
Cdd:COG2814   125 DLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF------------------GWRWVFLVNAVLALLALLLLL---R 183
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 339 QLPGSQRyvvmraaetqqlkdhsrdnpafgKTVRDLPLSVWILLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSL 418
Cdd:COG2814   184 LLPESRP-----------------------AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGL 240
                         330
                  ....*....|
gi 1958759677 419 SASEAATLFG 428
Cdd:COG2814   241 SASAAGLLLA 250
 
Name Accession Description Interval E-value
MFS_SLCO4A_OATP4A cd17462
Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of ...
101-484 0e+00

Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4A (SLCO4A), also called Organic anion-transporting polypeptide 4A (OATP4A), subfamily has one mammalian member, OATP4A1 (encoded by SLCO4A1). It is ubiquitously expressed and it mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4A1 is the most abundantly expressed transporter colorectal cancer (CRC) and its role in the transport of estrone sulfate, which is used in hormone replacement therapy (HRT), affects the outcome of the treatment. The SLCO4A/OATP4A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341020 [Multi-domain]  Cd Length: 427  Bit Score: 550.21  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 101 PKGFLFFLCAASFLQGMTVNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGALVLG 180
Cdd:cd17462     1 PKGVLFFLCAASFLQGMTVNGFINTVITSIERRFDLRSYQSGLIASSYDIAACLCLTFVSYFGGSGHKPRWLGWGVLIMG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 181 IGSLVFALPHFTagryeveiddeglgtetgtcltnqsqveckdrasglssyrlIFMLGQLLHGVGATPLYTLGVTYLDEN 260
Cdd:cd17462    81 LGSLVFALPHFT-----------------------------------------VFMLGQFLHGIGATPLYTLGVTYLDEN 119
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 261 VKSSYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYTEVGQRTELTTDSPLWVGAWWIGFLGAGIAAFLIAIPILGYPRQL 340
Cdd:cd17462   120 VKSNYSPVYIGIFYTAAIVGPAAGYLLGGFFLNIYTEIGRQTELTPENPLWVGAWWIGFLGAGAAALLIALPILGYPRQL 199
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 341 PGsqryvvmraaetqqlkdhsrdnpafgktvrdlplsvwiLLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSA 420
Cdd:cd17462   200 PG--------------------------------------LLKNPTFIFLCLAGATEATLIAGMSTFGPKFLESQFSLSA 241
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1958759677 421 SEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFCLFCTLTSLLAFFVFLMHCPNVHMA 484
Cdd:cd17462   242 SEAATLFGYLVVPAGGGGTFLGGFIVNKLKLRCSGIIKFCLICTVVSLLAIFIFSLHCPNVPMA 305
MFS_SLCO4_OATP4 cd17403
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...
101-484 2.06e-144

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340961 [Multi-domain]  Cd Length: 420  Bit Score: 420.51  E-value: 2.06e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 101 PKGFLFFLCAASFLQGMTVNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGALVLG 180
Cdd:cd17403     1 PKGFLFFLCIFAFLQGMVVNGFVNVSITTIEKRFGLTSTQTGLIASSYDIASVLLLLFVSYFGGRGHKPRWLGIGAFIMG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 181 IGSLVFALPHFTagryeveiddeglgtetgtcltnqsqveckdrasglssyrlIFMLGQLLHGVGATPLYTLGVTYLDEN 260
Cdd:cd17403    81 IGSLVFALPHFT-----------------------------------------VFILAQLLHGAGATPLYTLGVTYLDEN 119
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 261 VKSSYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYTEVGQRT---ELTTDSPLWVGAWWIGFLGAGIAAFLIAIPILGYP 337
Cdd:cd17403   120 VSTKMSPLYIGIFYAMAILGPAIGYVLGGFLLNLYTDIDQVDselGLTPDDPRWVGAWWLGFLISGALALIIAFPLLGFP 199
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 338 rqlpgsqryvvmraaetqqlkdhsrdnpafgktvrdlplsvwillrnPTFILLCLAGATEATLIAGMSTFGPKFFEAQFS 417
Cdd:cd17403   200 -----------------------------------------------PTFMFLNLAGASEGMLLAGFATFLPKLIESQFS 232
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958759677 418 LSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFCLFCTLTSLLAFFVFLMHCPNVHMA 484
Cdd:cd17403   233 LSASLAALLVGVVVVPGGILGTFLGGLIVKKLKLKCKGILKFCIVCSIVAFLFSFILLIYCPNAPFA 299
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
103-484 6.36e-137

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 405.05  E-value: 6.36e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 103 GFLFFLCAASFLQGMtVNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGALVLGIG 182
Cdd:pfam03137   1 FFLVFLSLLGLAQAL-VSGYFNSSITTIEKRFGLPSSLSGLISSSYDIGNLLLIVFVSYFGGKGHRPRWIGVGALLMGLG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 183 SLVFALPHFTAgryeveiddeglgtetgtcltnqsqveckdrasglssyrliFMLGQLLHGVGATPLYTLGVTYLDENVK 262
Cdd:pfam03137  80 SLLFALPHFLS-----------------------------------------FFLGQLLLGIGGTPIYTLGISYIDDNVK 118
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 263 SSYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYTEVGQRT-ELTTDSPLWVGAWWIGFLGAGIAAFLIAIPILGYPRQLP 341
Cdd:pfam03137 119 KKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVDIGKVSiTLTPKDPRWVGAWWLGFLIAGLLLLLTAIPFFFFPKSLP 198
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 342 GSQRYVVMRAAETQQL----KDHSRDNPAFGKTVRDLPLSVWILLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFS 417
Cdd:pfam03137 199 GAAKRRAKKKKEPHSQdiadLKKTKSLKKLGPSLKDFPKALKRLLKNPVYMLLTLASVFEFLLIAGYATFLPKYIETQFG 278
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1958759677 418 LSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFCLFCTLTSLLAFFVFL-MHCPNVHMA 484
Cdd:pfam03137 279 LSASTANLLTGVVAIPGAALGILLGGLIIKKFKLSAKGLAKFNVITSLVSLLLSLLLFfLGCPNSPVA 346
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
89-484 4.02e-97

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 306.27  E-value: 4.02e-97
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677  89 SFTPKCLQVFNTPKGFLFFLCAASFLQGMTVNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHK 168
Cdd:TIGR00805  18 KPRPRCLQSLFSKIKMFSLLLTCARLQGLLVNGLVNSMLTSIERRFKIPTSRSGFINGSYEIGNLLLIIFVSYFGTKLHR 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 169 PRWLGWGALVLGIGSLVFALPHFTAGRYEVEIDDEGLGTETG----TCLTNQSQV--------ECKDRASglSSYRLIFM 236
Cdd:TIGR00805  98 PIVIGAGCAIMGLGSLLSSLPHFLMGRYSYSTTVSSTGNLSSansfLCMENLTQTlrptqdpsECQKQHK--SLMWLLFL 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 237 LGQLLHGVGATPLYTLGVTYLDENVKSSYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYTEVG----QRTELTTDSPLWV 312
Cdd:TIGR00805 176 VSNILRGIGATPIFPLGISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYVDTGsvntEDLIITPTDPRWI 255
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 313 GAWWIGFLGAGIAAFLIAIPILGYPRQLPGSQRYVVMRAAETQQLKDH-SRDNPAFGKTVRDLPLSVWILLRNPTFILLC 391
Cdd:TIGR00805 256 GAWWIGFLVCGFVALLTSIPLFFFPKTLPKEGKRVNVDVHEAEKLEKSrGEDRKKNSGITKDFPKFIKRLLCNKIYMLVI 335
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 392 LAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRF-CLFCTLTSLLA 470
Cdd:TIGR00805 336 LAQVIDVLAFNGYITFLPKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKAAYFaICLSTLEYLLY 415
                         410
                  ....*....|....
gi 1958759677 471 FFVFLMHCPNVHMA 484
Cdd:TIGR00805 416 SPKFLITCESAPVA 429
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
101-484 3.23e-94

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 291.45  E-value: 3.23e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 101 PKGFLFFLCAASFLQGMTVNGFINTvITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGALVLG 180
Cdd:cd17336     1 PKVFVVLLCLLGLLQGAVVSYFVST-ITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 181 IGSLVFALPHFtagryeveiddeglgtetgtcltnqsqveckdrasglssyrliFMLGQLLHGVGATPLYTLGVTYLDEN 260
Cdd:cd17336    80 LGCFLLALPHF-------------------------------------------LFVGQFLLGIGSSPLYTLGITYIDDN 116
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 261 VKSSYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYTEVGQR-TELTTDSPLWVGAWWIGFLGAGIAAFLIAIPILGYPrq 339
Cdd:cd17336   117 VSKKNSPLYIGILYAMRVLGPALGFLLGSFLLRIYVDFSRVpLGITPDDPRWIGAWWLGFLILGILLLIVSIPLFFFP-- 194
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 340 lpgsqryvvmraaetqqlkdhsrdnpafgktvrdlplsvwillrnPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLS 419
Cdd:cd17336   195 ---------------------------------------------PIFILLLLAIVFESFAISGFSTFLPKYLETQFRLS 229
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958759677 420 ASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFCLFCTLTSLLAF-FVFLMHCPNVHMA 484
Cdd:cd17336   230 ASLASLLTGLILVPGAALGILLGGLIIKKFKLTARGLAKFVLILSLLSVILYiSLFFLGCDNPPIA 295
MFS_SLCO4C_OATP4C cd17463
Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of ...
101-484 5.75e-94

Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4C (SLCO4C), also called Organic anion-transporting polypeptide 4C (OATP4C), subfamily has one mammalian member, OATP4C1 (encoded by SLCO4C1). It is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. It is the only OATP expressed at the basolateral side of proximal tubular cells in human kidney and it mediates the excretion of uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs) and cause further progression of renal damage and cardiovascular diseases. Overexpression of human SLCO4C1 in rat kidney promotes the renal excretion of uremic toxins and reduces hypertension, cardiomegaly, and renal inflammation in renal failure. The SLCO4C/OATP4C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341021 [Multi-domain]  Cd Length: 429  Bit Score: 291.65  E-value: 5.75e-94
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 101 PKGFLFFLCAASFLQGMTVNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGALVLG 180
Cdd:cd17463     1 PKGYLLFYSLLAVVQGIVVNGLVNISISTIEKRYELSSSLTGLISSSYDISFCLLSLFVSFYGERGHKPRWLAFSAFMIG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 181 IGSLVFALPHFTagryeveiddeglgtetgtcltnqsqveckdrasglssyrlIFMLGQLLHGVGATPLYTLGVTYLDEN 260
Cdd:cd17463    81 LGSLVFSLPHFF-----------------------------------------VFILGQLLLGVGGTPLYTLGTAYIDDS 119
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 261 VKSSYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYTEV--GQRTELTTDSPLWVGAWWIGFLGAGIAAFLIAIPILGYPR 338
Cdd:cd17463   120 VPTHKSSLYIGIGYGMSVLGPAIGYLLGGQLLNIYIDVnkGQSVDLTEEDPRWLGAWWIGFLMCWLIAWCLIAPFSCFPK 199
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 339 QLPGsqryvvmraaetqqlkdhsrdnpafgktvrdlplsvwiLLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSL 418
Cdd:cd17463   200 HLPG--------------------------------------LLKNPVFMCLTISSCSEALITTGFATFLPKFIENQFGQ 241
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958759677 419 SASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFCLFCTLTSLLAFFVFLM-HCPNVHMA 484
Cdd:cd17463   242 TSSFAAILGGLVLIPGAAIGQILGGIIVSKFKLKCKNMIKFAIITTTVSLLLLSVFIFaKCGNDPFA 308
MFS_SLCO5_OATP5 cd17404
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...
102-484 2.29e-84

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340962 [Multi-domain]  Cd Length: 425  Bit Score: 266.53  E-value: 2.29e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 102 KGFLFFLCAASFLQGMTVNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGALVLGI 181
Cdd:cd17404     1 KAFLVCMCLLIFIQSALSSGYLNSVITTIEKRYSLKSSESGLIVSSYEIGSLLTVVFVSYFGGRGHRPRWIAVGGVLIAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 182 GSLVFALPHFtagryeveiddeglgtetgtcltnqsqveckdrasglssyrliFMLGQLLHGVGATPLYTLGVTYLDENV 261
Cdd:cd17404    81 GSFLFSLPHF-------------------------------------------FILAQILIGMGGTPIFTLGTTYLDDHV 117
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 262 KSSYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYTEVGQRT-ELTTDSPLWVGAWWIGFLGAGIAAFLIAIPILGYPRql 340
Cdd:cd17404   118 KKESSSLYLAIMYVMGALGPAAGFLLGGLLINFYVDPLSTPpDISPGDPRWIGAWWGGFLLCGIALLLVAFPFFTFPK-- 195
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 341 pgsqryvvmraaetqqlkdhsrdnpafgktvrdlplsvwillrnPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSA 420
Cdd:cd17404   196 --------------------------------------------MTFLVVSLGYCMELAIVSGFITFLPKYLETQFGIPA 231
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958759677 421 SEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFCLFCTLTSLLAFF-VFLMHCPNVHMA 484
Cdd:cd17404   232 SNANIFTGVIAVPGAGIGIVLGGYILKRFKLGPKGAAKLALICNFLSLLLFLtLFFLGCESIKLA 296
MFS_SLCO2B_OATP2B cd17460
Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of ...
106-491 2.90e-62

Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2B (SLCO2B), also called Organic anion-transporting polypeptide 2B (OATP2B), subfamily has one mammalian member, OATP2B1 (encoded by SLCO2B1). It mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. It also mediates the transport of endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). SLCO2B1 variations result in differential expression and uptake of DHEAS, which impacts subsequent resistance to androgen-deprivation therapy (ADT), the primary treatment of metastatic prostate cancer. The SLCO2B/OATP2B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341018 [Multi-domain]  Cd Length: 479  Bit Score: 210.40  E-value: 2.90e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 106 FFLCAASFLQ--GMTVNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGALVLGIGS 183
Cdd:cd17460     3 FFVLCHGLLQlsQLLVSGYLKSSISTIEKRFGLSSQTSGLLASFNEVGNTVLIVFVSYFGSRVHRPRFIGCGAILVSLAG 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 184 LVFALPHFTAGRYEveiddeglgtetgtcltnqsqveckdrasglssYRLIFmLGQLLHGVGATPLYTLGVTYLDENVKS 263
Cdd:cd17460    83 FLMALPHFISEPYE---------------------------------YGILF-LGQLLLGIGGVPIQPFGISYIDDFASE 128
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 264 SYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYTEVGQRTE----LTTDSPLWVGAWWIGFLGAGIAAFLIAIPILGYPRQ 339
Cdd:cd17460   129 SNSPLYLGILFAVTVLGPGFGFMLGSAMLRFYVDIDKMSEdeisLEIGDPRWVGAWWLGFLIAATLVALSAVPYFFFPRE 208
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 340 LP-----GSQRYVVMRAAETQQLKDHSRDNPAFGKT--VRDLPLSVWILLRNPTFILLCLAGATEATLIAGMSTFGPKFF 412
Cdd:cd17460   209 MPkevveLQPREKKLAKTMLKKLKSLSDILQNLSLLqfIKKFPRILLRTLRNPIYLLVVLAQVNLSAMVAGLATFMGKFL 288
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 413 EAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFCLFCTLTSL-LAFFVFLMHCPNVHMAASCLRDS 491
Cdd:cd17460   289 ERQFSITASFANLMIGGLNIPSAMVGIVVGGVILKRLQLTVRGCGAMCVLGMLLCLfFALPLLFIGCSTQKIAGITHRTS 368
MFS_SLCO1C_OATP1C cd17459
Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of ...
104-484 5.50e-59

Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1C (SLCO1C), also called Organic anion-transporting polypeptide 1C (OATP1C), subfamily contains one mammalian member, OATP1C1 (encoded by SLCO1C1), which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine), as well as organic anions such as 17-beta-glucuronosyl estradiol, estrone-3-sulfate, and sulfobromophthalein (BSP), which are transported with much lower efficiency. The SLCO1C/OATP1C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341017 [Multi-domain]  Cd Length: 498  Bit Score: 202.30  E-value: 5.50e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 104 FLFFLCAASF--LQGMTVNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGALVLGI 181
Cdd:cd17459     1 LKIFLAALSFayFAKALSGSYMKSTITQIERRFDIPSSLIGVIDGSFEMGNLLVIAFVSYFGAKLHRPRIIGAGCLLMAI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 182 GSLVFALPHFTAGRYEVEIDDEGLGTETGT---CL-------------TNQSQVECKdRASGLSSYRLIFmLGQLLHGVG 245
Cdd:cd17459    81 GTFLIALPHFFMGRYKYETAIQSSSNSTVSispCSlepspqlhsiessDSKTGTGCE-KEPGSSMWIYVF-LGNLLRGIG 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 246 ATPLYTLGVTYLDENVKSSYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYTEVG----QRTELTTDSPLWVGAWWIGFLG 321
Cdd:cd17459   159 ETPVQPLGISYIDDFAKEENAAFYIGCVQTIAIIGPVFGFLLGSLCAKLYVDIGfvnlDSITITPKDARWVGAWWLGYLI 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 322 AGIAAFLIAIPILGYPRQLPgsqryvvmraaetqqlkdhsrdnpafgktvRDLPLSVWILLRNPTFILLCLAGATEATLI 401
Cdd:cd17459   239 AGVITLLSAVPFWFLPKSLP------------------------------KDFLPSLKNLLGNPVYFLYLCTSILQFNSL 288
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 402 AGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFCLFCTLTS-LLAFFVFLMHCPN 480
Cdd:cd17459   289 IGMVTYKPKYIEQQYGQSASKANFLIGLINIPAVAIGIFSGGLLMKKFKLSVIGAAKLSFGTSFFGyLLLLSFFAMGCEN 368

                  ....
gi 1958759677 481 VHMA 484
Cdd:cd17459   369 SDVA 372
MFS_SLCO1A_OATP1A cd17458
Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of ...
102-480 1.26e-58

Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1A (SLCO1A), also called Organic anion-transporting polypeptide 1A (OATP1A), subfamily is composed of one human member OATP1A2 (encoded by SLCO1A2) and several rodent proteins encoded by the Slco1a1, Slco1a3, Slco1a4, Slco1a5, and Slco1a6 genes. OATP1A2, also known as human OATP-A or OATP1, shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). It is expressed in the brain, kidney, intestine, liver, lung, testes, and the eye (ciliary body). The SLCO1A/OATP1A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341016 [Multi-domain]  Cd Length: 527  Bit Score: 202.01  E-value: 1.26e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 102 KGFLFFLCAASFLQGMTvNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGALVLGI 181
Cdd:cd17458     3 KIFLLALSYAYVAKTLS-GAYMNSMITQIERRFNIPSSLVGIINGSFEIGNLLVIAFVSYFGAKLHRPKVIGLGCLIMSL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 182 GSLVFALPHFTAGRYEVE---IDDEGLGTETGTCLTNQSQV--------ECKdraSGLSSYRLIF-MLGQLLHGVGATPL 249
Cdd:cd17458    82 GCFLASLPHFLMGRYEYEstvSTTSNSSSRVPLCLANQSLShnvtqlpsECE---KESMSLMWIFvLVGNLLRGIGETPV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 250 YTLGVTYLDENVKSSYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYTEVGQ-RTELTTDSPL---WVGAWWIGFLGAGIA 325
Cdd:cd17458   159 MPLGISYIDDFSKKENSPFYIGCLHTATIVGPLLGLLLASFCAQLYVDLGSvNADDLTITPTdirWVGAWWLGFLICAGV 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 326 AFLIAIPILGYPRQLP--GSQRYVVMRAAETQQLKDHSRDNPA---FGKTVRDLPLsVWILLRNPTFILLCLAGATEATL 400
Cdd:cd17458   239 NFLAGLPFWFLPKSLPkeGEENETEPSKTLTVELEENKGQETKqemYEIAKDFLPF-LKSLFRNPIYMLFIIVTVLQFNA 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 401 IAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKL---RGSGIIrfCLFCTLTSLLAFFVFLMH 477
Cdd:cd17458   318 FSGMISFMPKYLEQQYGKSASDAIFLIGVYNLPIICLGYFFGGLYMKKFKIntyQAAHIG--FWVSLLEYLLYFSAFWMG 395

                  ...
gi 1958759677 478 CPN 480
Cdd:cd17458   396 CDN 398
MFS_SLCO3_OATP3 cd17402
Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of ...
102-475 4.71e-56

Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 3 (SLCO3) or Organic anion transporting polypeptide 3 (OATP3) family contains only one subfamily, OATP3A, which contains only one mammalian member OATP3A1 (encoded by SLCO3A1). It mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate, prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123, and vasopressin. SLCO3A1 has been identified as a Crohn's disease (CD)-associated gene, which mediates inflammatory processes in intestinal epithelial cells through NF-kappaB transcription activation, resulting in a higher incidence of bowel perforation in CD patients. The SLCO3/OATP3 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340960 [Multi-domain]  Cd Length: 444  Bit Score: 193.22  E-value: 4.71e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 102 KGFLFFLCAASFLQGmTVNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGALVLGI 181
Cdd:cd17402     2 KIFLVSECALMLAQG-TVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 182 GSLVFALPHFTAGRYEVEIddeglgtetgtcltnqsqveckdrasglssYRLIFMLGQLLHGVGATPLYTLGVTYLDENV 261
Cdd:cd17402    81 GALLSALPEFLTHQYKTNM------------------------------MYLLLIGAQVLLGIGATPVQPLGVSYIDDHV 130
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 262 KSSYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYTEV----GQRTELTTDSPLWVGAWWIGFLGAGIAAFLIAIPILGYP 337
Cdd:cd17402   131 RRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAvfidTSKLDITPDDPRWIGAWWGGFLLCGALLFFSALLMFGFP 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 338 RQLpgsqryvvmraaetQQLkdhsrdnpafgktvRDLPLSVWILLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFS 417
Cdd:cd17402   211 QSL--------------QQL--------------RVIPKVTKHLLSNPVFTCIVLAACMEIAVVAGFAAFLGKYLEQQFN 262
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1958759677 418 LSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFCLFCTLTSLLAFFVFL 475
Cdd:cd17402   263 LTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFL 320
MFS_SLCO2A_OATP2A cd17461
Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of ...
105-479 7.94e-56

Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2A (SLCO2A), also called Organic anion-transporting polypeptide 2A (OATP2A), subfamily has one mammalian member, OATP2A1 (encoded by SLCO2A1), which is also called prostaglandin transporter. It is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Mutations in SLCO2A1 can cause primary hypertrophic osteoarthropathy (PHO), a rare multi-organic disease characterized by digital clubbing, pachydermia and periosteal reaction. The SLCO2A/OATP2A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341019 [Multi-domain]  Cd Length: 474  Bit Score: 193.48  E-value: 7.94e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 105 LFFLCAASF-LQGMTVNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGALVLGIGS 183
Cdd:cd17461     4 VFVLCHGLLqLSQLLYSAYFKSSLTTIEKRFGLSSLSSGLISSLHEIGNAVLIIFVSYFGSRVHRPRLIGIGGLLLALGA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 184 LVFALPHFTAGRYEVeiddeglgtetgtcltnqsqveckdrasglsSYRLIFMLGQLLHGVGATPLYTLGVTYLDENVKS 263
Cdd:cd17461    84 FLLTLPHFLSEPYQY-------------------------------SMWVLMVVAQLLAGIGTVPIQPFGISYVDDFAEP 132
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 264 SYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYTEVGQ----RTELTTDSPLWVGAWWIGFLGAGIAAFLIAIPILGYPRQ 339
Cdd:cd17461   133 SNSPLYIAILFAISVFGPAFGYLLGSVVLRIFVDIGRvntaTVELTPADPRWIGAWWLGLLISSGLLVLTSLPYFFFPRE 212
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 340 LPgSQRYVVMRAAETQQLKDHSRDNPAFGKTVRDLPLSVWILLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLS 419
Cdd:cd17461   213 ML-VGKKPSPEGDMLRKKEDEKKEEGSLLDFIKRFPKMFVKLLLNPLFMLLVLAQCTFSSVIAGLSTFLNKFLEKQYGAS 291
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958759677 420 ASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFCLFCTLTS-LLAFFVFLMHCP 479
Cdd:cd17461   292 ASYANFLIGAVNLPAAALGMLLGGIIMKRFGFSLRAIPRFSVVILSISiMLCVPLFFMGCS 352
MFS_SLCO2_OATP2 cd17401
Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of ...
105-491 4.88e-54

Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2 (SLCO2) or Organic anion transporting polypeptide 2 (OATP2) family contains two subfamilies: OATP2A and OATP2B, each containing one mammalian member, OATP2A1 and OATP2B1, respectively. OATP2A1 (encoded by SLCO2A1) is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. OATP2B1 (encoded by SLCO2B1) mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost, as well as endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). The SLCO2/OATP2 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340959 [Multi-domain]  Cd Length: 440  Bit Score: 187.75  E-value: 4.88e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 105 LFFLCAASF-LQGMTVNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGALVLGIGS 183
Cdd:cd17401     3 VFVLCHGLLqLCQLLYSGYLKSSITTIEKRFGLSSSSSGLLASFNEVGNTILIVFVSYFGSRVHRPRLIGIGGLFLAAGA 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 184 LVFALPHFTAGRYEveiddeglgtetgtcltnqsqveckdrasglssYRLIFmLGQLLHGVGATPLYTLGVTYLDENVKS 263
Cdd:cd17401    83 FLLTLPHFISEPYQ---------------------------------YGIMV-VAQLLLGIGGVPIQPFGISYIDDFAEP 128
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 264 SYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYTEVGQRTE----LTTDSPLWVGAWWIGFLGAGIAAFLIAIPILGYPRQ 339
Cdd:cd17401   129 SNSPLYLGILFAVTVFGPAFGYLLGSVMLRLYVDIGRMNTaavnLVPGDPRWIGAWWLGFLIAAALLVLTSFPYFFFPRF 208
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 340 LpgsqryvvmraaetqqlkdhsrdnpafgktvRDLPLSVWILLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLS 419
Cdd:cd17401   209 I-------------------------------KRFPCIFLRTLRNPIFLLVVLAQVTLSSMIAGLATFLNKFLEKQFGTT 257
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958759677 420 ASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFCLFCTLTSL-LAFFVFLMHCPNVHMAASCLRDS 491
Cdd:cd17401   258 ASYANFLIGAVNLPSAALGILFGGVLMKRLVLSLQAIPAICTTIITISMiFCVPLFFIGCSTPTIAGVYPPSS 330
MFS_SLCO1_OATP1 cd17400
Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of ...
107-484 1.06e-45

Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1 (SLCO1) or Organic anion transporting polypeptide 1 (OATP1) family contains three subfamilies: OATP1A, OATP1B, and OATP1C. OATP1A contains one human member, OATP1A2, which shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). OATP1B contains two human proteins, OATP1B1 and OATP1B3, which can both accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). OATP1C contains one mammalian member, OATP1C1, which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine). The SLCO1/OATP1 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340958 [Multi-domain]  Cd Length: 436  Bit Score: 165.01  E-value: 1.06e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 107 FLCAAS--FLQGMTVNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGALVLGIGSL 184
Cdd:cd17400     4 FLLALScaFVAKTLSGSYMKSMITQIERRFNIPSSLVGFIDGSFEIGNLLVIIFVSYFGTKLHRPKMIGIGCVIMGLGCF 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 185 VFALPHFTAGRYEveiddeglgtetgtcltnqsqveckdrasgLSSYRLIFMLGQLLHGVGATPLYTLGVTYLDENVKSS 264
Cdd:cd17400    84 LKALPHFFMNQYE------------------------------YSLMWIYVFVGNILRGIGETPILPLGISYIDDFAKEE 133
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 265 YSPIYIAIFYTAAILGPAAGYLIGGAMLNVYTEVG----QRTELTTDSPLWVGAWWIGFLGAGIAAFLIAIPILGYPrql 340
Cdd:cd17400   134 NSPLYIGLVETGAIIGPIIGFLLGSLCAKVYVDIGfvnlDDIIITPTDTRWVGAWWLGFLICGGVSVLTAIPFFFLP--- 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 341 pgsqryvvmraaetqqlkdhsrdnpafgktvrdlplsvwillrnPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSA 420
Cdd:cd17400   211 --------------------------------------------PIYMLFILVSVIQFNSFVGMITYMPKYLEQQYGQSS 246
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958759677 421 SEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFCLFCTLTSLLAFFV-FLMHCPNVHMA 484
Cdd:cd17400   247 SDANFLMGIINIPPIAIGYFIGGLIMKKFKITVKGAAKIGCWLSVLEYLLYLLsFLMTCENSSVA 311
MFS_SLCO1B_OATP1B cd17457
Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of ...
102-477 2.39e-45

Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1B (SLCO1B), also called organic anion-transporting polypeptide 1B (OATP1B), subfamily is composed of two human proteins, OATP1B1 (encoded by SLCO1B1) and OATP1B3 (encoded by SLCO1B3), and one rodent member, OATP1B2 (encoded by Slco1b2). OATP1B1 and OATP1B3 are almost exclusively expressed on the basal side of hepatocytes in normal human organs. They both can accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). Loss-of-function mutations in both SLCO1B1 and SLCO1B3 genes result in the Rotor syndrome, a hereditary hyperbilirubinemia. The SLCO1B/OATP1B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341015 [Multi-domain]  Cd Length: 455  Bit Score: 164.63  E-value: 2.39e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 102 KGFLFFLCAASFLQGMTvNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGALVLGI 181
Cdd:cd17457     2 KMFLAALSFSYFAKALS-GIIMKSSITQIERRFDISSSTVGFIDGSFEIGNLLVIAFVSYFGAKLHRPKLIAAGCFIMGL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 182 GSLVFALPHFTAGRYEVEiddeglgtetgtCLTNQsqveckdrasglSSYRLIFML-GQLLHGVGATPLYTLGVTYLDEN 260
Cdd:cd17457    81 GSVLTALPHFFMGYYKYG------------CLKES------------GSYMWVYVLmGNMLRGIGETPIVPLGISYLDDF 136
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 261 VKSSYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYTEVG----QRTELTTDSPLWVGAWWIGFLGAGIAAFLIAIPILGY 336
Cdd:cd17457   137 AKEENSPLYLACLHTIAMIGPMIGFTLGSLFAKLYVDIGfvdlSTIRITPQDSRWVGAWWLGFLVSGLFSIISAIPFFFL 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 337 PrqlpgsqryvvmraaetqqlkdhsrdnpafgktvrDLPLSVWILLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQF 416
Cdd:cd17457   217 P-----------------------------------GFFQSLKSILTNRLYVMFVCLTLLQVSSFIGFFTYKPKYMEQQY 261
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958759677 417 SLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFCLFctlTSLLAFFVFLMH 477
Cdd:cd17457   262 GQSSSKANFLLGVITLPIFASGMFLGGYIMKKYKLNTVGAAKFACF---TSVMALSFYLLY 319
MFS_SLCO6_OATP6 cd17405
Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of ...
102-484 1.11e-40

Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 6 (SLCO6) or Organic anion transporting polypeptide 6 (OATP6) family contains only one subfamily, OATP6A, which contains only one human member OATP6A1 (encoded by SLCO6A1). The OATP6 family is the most diverged of the OATPs. OATP6A1 is also called cancer/testis antigen 48 (CT48) or gonad-specific transporter. It is strongly expressed only in normal testis, and weakly in spleen, brain, fetal brain, and placenta. It is found in tumor samples (lung, bladder, and esophageal) and cancer cell lines (lung), and may be of potential use as a target for therapy for a variety of tumor types. The SLCO6/OATP6 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340963 [Multi-domain]  Cd Length: 428  Bit Score: 151.15  E-value: 1.11e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 102 KGFLFFLCAASFLQGMtVNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGALVLGI 181
Cdd:cd17405     2 DGFMILYCILVLIQGA-VFGLVDMSIGIFQVQFSLTRTEKYLLDFSYDISSFLVAIIIAHYGSRGNRTRWIAASCFLMGL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 182 GSLVFALPHFTagryeveiddeglgtetgtcltnqsqveckdrasglssyrlIFMLGQLLHGVGATPLYTLGVTYLDENV 261
Cdd:cd17405    81 GSMLFAFPFFT-----------------------------------------FHIAGQCIQGIAGMPIYILGITFIFDNI 119
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 262 KSSYSPIYIAIFYTAAILGPAAGYLIGGAMLNV-YTEVGQRTELTTDSPLWVGAWWIGFLGAGIAAFLIAIPILGYPRQL 340
Cdd:cd17405   120 PTSSAGIYLGIAHSAYLIGYLLGYVGGLPNFQPpPNEKSVEIEVNKVYQLWQSGWWKTFLIAAAIAWCTSFPLVCFPTSL 199
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 341 PGsqryvvmraaetqqlkdhsrdnpafgktvrdlplsvwiLLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSA 420
Cdd:cd17405   200 PG--------------------------------------LLKNPLLLCQAICKATEYLTFIGALEFLPHYLENQFLLTP 241
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1958759677 421 SEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFCLFCTLTSLLAF-FVFLMHCPNVHMA 484
Cdd:cd17405   242 GIASLLTGAFLIPGGAIGHFLGGLIVSRLEMSCKNKMRFILVTSVISLGLFvLIFFVECQTVTFA 306
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
100-428 5.94e-10

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 60.76  E-value: 5.94e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 100 TPKGFLFFLCAASFLQGMTvNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGALVL 179
Cdd:COG2814     7 RRWLALLALALGAFLSGLG-IGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLF 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 180 GIGSLVFAL-PHFTagryeveiddeglgtetgtcltnqsqveckdrasglssyrlIFMLGQLLHGVGATPLYTLGVTYLD 258
Cdd:COG2814    86 ALGSLLCALaPSLW-----------------------------------------LLLAARFLQGLGAGALFPAALALIA 124
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 259 ENVKSSYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYtevgqrtelttdsplwvgAWWIGFLGAGIAAFLIAIPILgypR 338
Cdd:COG2814   125 DLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF------------------GWRWVFLVNAVLALLALLLLL---R 183
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 339 QLPGSQRyvvmraaetqqlkdhsrdnpafgKTVRDLPLSVWILLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSL 418
Cdd:COG2814   184 LLPESRP-----------------------AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGL 240
                         330
                  ....*....|
gi 1958759677 419 SASEAATLFG 428
Cdd:COG2814   241 SASAAGLLLA 250
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
108-434 1.19e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 53.73  E-value: 1.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 108 LCAASFLQGMTVnGFINTVITSIERRFDLHSYQSGLIASSYDIAaclcLTFVSYFGGN-----GHKpRWLGWGALVLGIG 182
Cdd:cd17325     1 LSLALFLDMLGY-GIIIPILPLYAESLGASVAQIGLIVAAYALA----QLLFSPPAGRlsdrfGRK-RLLLLGLLLLAVS 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 183 SLVFALphftAGRYEVeiddeglgtetgtcltnqsqveckdrasglssyrliFMLGQLLHGVGATPLYTLGVTYLDENVK 262
Cdd:cd17325    75 TLLFAF----ATSYWQ------------------------------------LLLARFLQGLASAAVWPAAMALIADIAP 114
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 263 SSYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYtevgqrtelttdsplwvgAWWIGFLGAGIAAFLIAIPILGYprqlpg 342
Cdd:cd17325   115 PEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL------------------GYRAPFLVCAALALLALVLALLL------ 170
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 343 sqryvvmraaetqqLKDHSRDNPAFGKTVRDLPLSVWILLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASE 422
Cdd:cd17325   171 --------------LPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQ 236
                         330
                  ....*....|..
gi 1958759677 423 AATLFGYLVVPA 434
Cdd:cd17325   237 IGLLFGAQGLAS 248
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
108-432 1.67e-06

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 50.12  E-value: 1.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 108 LCAASFLQGMTVNGFiNTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGALVLGIGSLVFA 187
Cdd:cd06174     1 LLLGFFLTGLARGLI-SPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 188 LPHftagryeveiddeglgtetgtcltnqsqveckdrasglssYRLIFMLGQLLHGVGATPLYTLGVTYLDENVKSSYSP 267
Cdd:cd06174    80 FAP----------------------------------------SFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERG 119
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 268 IYIAIFYTAAILGPAAGYLIGGAMLNVYTevgqrtelttdsplwvGAWWIGFLGAGIAAFLIAIPILGYPRQLPGSQRYV 347
Cdd:cd06174   120 RALGLLQAFGSVGGILGPLLGGILASSLG----------------FGWRAVFLIAAALALLAAILLLLVVPDPPESARAK 183
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 348 VMRAAETQQLKDhsrdnpafgktvrdlplsVWILLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLF 427
Cdd:cd06174   184 NEEASSKSVLKL------------------LKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLL 245

                  ....*
gi 1958759677 428 GYLVV 432
Cdd:cd06174   246 SLFGL 250
MFS_1 pfam07690
Major Facilitator Superfamily;
108-488 5.49e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 45.10  E-value: 5.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 108 LCAASFLQGMTVNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGALVLGIGSLVFA 187
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 188 LphftagryeveiddeglgtetgtcltnqsqveckdrasglSSYRLIFMLGQLLHGVGATPLYTLGVTYLDENVKSSYSP 267
Cdd:pfam07690  81 F----------------------------------------ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERG 120
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 268 IYIAIFYTAAILGPAAGYLIGGAMLNVYTevgqrtelttdsplWVGAWWIGFLGAGIAAFLIAIPilgyprqlpgsqryv 347
Cdd:pfam07690 121 RALGLVSAGFGLGAALGPLLGGLLASLFG--------------WRAAFLILAILSLLAAVLLLLP--------------- 171
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 348 vmraaetqqLKDHSRDNPAFGKTVRDLPLSVWILLRNPTFILLCLAGATEATLIAGMSTFGPKFFEaQFSLSASEAATLF 427
Cdd:pfam07690 172 ---------RPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQE-VLGLSALLAGLLL 241
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1958759677 428 GYLVVpAGGGGTLLGGFLVNKFKLRGSGIIrFCLFCTLTSLLAFFVFLMHCPNVHMAASCL 488
Cdd:pfam07690 242 GLGGL-LGAIGRLLLGRLSDRLGRRRRLLL-ALLLLILAALGLLLLSLTLSSLWLLLALLL 300
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
270-428 1.97e-04

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 43.76  E-value: 1.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 270 IAIFYTAAILGPAAGYLIGGAMLNvytevgqrtelttdsplWVGAWWIGFLGAGIAAFLIAIPILgyprqlpgsqryVVM 349
Cdd:cd17328   125 LGVFYFAIPLGSGLGYVVGGLVAQ-----------------ATGGWRWAFRVTGVLGVLLAILLL------------LFV 175
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 350 RAAETQQLKDHSRDNPAFGKTVRDLplsvWILLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFS---LSASEAATL 426
Cdd:cd17328   176 REPPRGAAEGGVMAKSTATSFLADL----KALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGvgdLSSADVGLI 251

                  ..
gi 1958759677 427 FG 428
Cdd:cd17328   252 FG 253
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
235-434 4.16e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 42.56  E-value: 4.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 235 FMLGQLLHGVGATPLYTLGVTYLDENVKSSYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYtevgqrtelttdsplwvgA 314
Cdd:COG2223    96 LLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF------------------G 157
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 315 WWIGFLGAGIAAFLIAIPILGYprqlpgsqryvvmraaetqqlkdhSRDNPAFGKTVRDLPLSVWI-LLRNPTFILLCLA 393
Cdd:COG2223   158 WRNAFLILGILLLVVAVLAWLF------------------------LRDPPAGAAAAAKASLRDQLeALRDPRFWLLSLL 213
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1958759677 394 GATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPA 434
Cdd:COG2223   214 YFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLG 254
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
105-474 4.93e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 39.08  E-value: 4.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 105 LFFLCAASFLQGMTVNGFiNTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGALVLGIGSL 184
Cdd:COG2271    12 LALLFLAYFLNYLDRSNL-SVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATL 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 185 VFALphftagryeveiddeglgtetgtcltnqsqveckdrASGLssyrLIFMLGQLLHGVGATPLYTLGVTYLDENVKSS 264
Cdd:COG2271    91 LFGF------------------------------------ATSF----WQLLLLRFLLGLGEAGFFPAALKLIAEWFPPK 130
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 265 YSPIYIAIFYTAAILGPAAGYLIGGAMLNVYtevgqrtelttdsplwvgAWWIGFLGAGIAAFLIAIPilgyprqlpgsq 344
Cdd:COG2271   131 ERGRALGIFNAGGPLGGALAPPLLGWLLAAF------------------GWRAAFLILGLPGLLLALL------------ 180
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 345 ryvvmraaetqqlkdhsrdnpafgktvrdlplsvwillrnpTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAA 424
Cdd:COG2271   181 -----------------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAG 219
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1958759677 425 TLFGYLVVpAGGGGTLLGGFLVNKFKLRGSGIIRFCLFCTLTSLLAFFVF 474
Cdd:COG2271   220 LLLSLPFL-AGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALL 268
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
105-434 8.01e-03

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 38.25  E-value: 8.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 105 LFFLCAASFLQGMTVnGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGN-GHKpRWLGWGALVLGIGS 183
Cdd:COG0477    16 LLALALGTFLEGLDF-TIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRyGRK-RVLLIGLLLFGLAS 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 184 LVFALphftagryeveiddeglgtetgtcltnqsqveckdrASGLssyrLIFMLGQLLHGVGATPLYTLGVTYLDENVKS 263
Cdd:COG0477    94 LLCGL------------------------------------APSP----ELLIAARALQGIGAGGLMPGALALIAELFPA 133
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 264 SYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYTevgqrtelttdsplWVGAWWIGFLGAGIAAFLIaipilgypRQLPGS 343
Cdd:COG0477   134 RERGRALGLWGAAIGLGLALGPLLGGLLVAALG--------------WRWIFLINAPLGLLALVLR--------LRLPES 191
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958759677 344 QRYVVMRAAETQQLKDHSRDNPAFGKTVRDLPLSVWILLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEA 423
Cdd:COG0477   192 RGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLL 271
                         330
                  ....*....|.
gi 1958759677 424 ATLFGYLVVPA 434
Cdd:COG0477   272 LALLLALLLLL 282
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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