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Conserved domains on  [gi|1958734654|ref|XP_008770012|]
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junctional cadherin 5-associated protein isoform X2 [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
JCAD super family cl25806
Junctional protein associated with coronary artery disease; JCAD is a component of ...
 1-1181 0e+00

Junctional protein associated with coronary artery disease; JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells. The cell-cell or adherens junction is an adhesion complex that plays a crucial role in the organization and function of epithelial and endothelial cellular sheets. These junctions join the actin cytoskeleton to the plasma membrane to form adhesive contacts between cells or between cells and extracellular matrix. The junctions also mediate both cell adhesion and cell-signalling. JCAD localizes close to the apical membrane in epithelial cells. This family is found in eukaryotes.


The actual alignment was detected with superfamily member pfam15351:

Pssm-ID: 434658  Cd Length: 1358  Bit Score: 1593.61  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654    1 MAQAHSLPIHVRESPWEVARRTEHVMKNALWEAELRMPTPAKWQDMTLESWKQPRKLGRQASDGDGQKRsqerFEDLYQF 80
Cdd:pfam15351  140 MAQAHSLPVHVREGPWEVGGRTEHVMKKAVWEEELRMSGPAKWQNVSLESWNQPRKLGRQMSDGDGEKL----FQDLYPF 215

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654   81 VHGEHMLTSQNRKKSQSLPRALSPKSLNFTEIPVPLHDGHITGVPKVPPYPPSCPPPLEPTRNLEKTSSSGPFPRPKFGK 160
Cdd:pfam15351  216 IQGEHVLTSQNKGKSQSLPRVLSPESLSCMEIPIPLNDGHLPGVPKMPPYPPNCAPNLESTRNPEKGGSSAPLPRPKFGR 295

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654  161 PLKTPCHGSQPQPRG---EGGFQDHQHRDPRGCHPTRSKDPGHELGMLDTGLEPPVYVPPPSYRSPPQHIPNPYLEDPIP 237
Cdd:pfam15351  296 PLKPPSYESHQQSRGgveNSDYQDSQQADLCVSYLTRTSDPRQELCAPDPGLEPPVYVPPPSYRSPPQHIPNPYLEDAVP 375

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654  238 RHVSSSQSQQQQLPEKPEADCLLPSGSLAARDLYNAMPGSPPPGPPPHPYpIATHGDSIQYIPFDDPRIRHIKLAQPPEF 317
Cdd:pfam15351  376 RHVSGGHSQQQHPTEKPGASCQLPSGSLGTGNEYGASPRSPRGLPPHPRP-VTAYDGSVQYIPFDDPRIRHIKLAQPQGF 454

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654  318 YEEARLEDTSYNSGFIATQEPALGKRQYNDALSAPRGPILPPVNERGSAFAHSSPQWLQGQLPMASEPGGFPGQTEHHGM 397
Cdd:pfam15351  455 CEETKLDDKSYSSGPVTAQEPARGEMQHDGAVLNPQSLTPPSGSERGPAFADPSPRWLWGQLPRDGENGGFPDQRDHCVV 534

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654  398 RGLTADVRDSK---VESHASSPQPQSEGTCRTHTKLRKFETGIQSRKSSK-KSNATIFCLVSVPVKSESLVPDTDTNNND 473
Cdd:pfam15351  535 RGQWPDVRGSQhghAEGQVSSPSPQGESTCETQTKLKKFETGIQTKKSSKkKMNETIFCLVSIPVKSESHLPDTDTNNND 614

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654  474 LKLGADKNHGLYQGPALEEQSLLSMSSTDLELQALMGSMAWRRTSPRQVLGESE-DGQTDDPRTLHLIKPRELRASGSWP 552
Cdd:pfam15351  615 LKQSADKKNGLDKSGALQEQSLLSMSSTDLELQALTGSMAGRTELQKQDLGEPEeDKQTNDLRFIHPAKHRELKYSGSWP 694

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654  553 GHQYRDQQTQTSFPEDSKSSQLLPATKPGEASNAALTPTCPDDTASEVHLHAALASSDPSQKPSVPHLRGQMSLSPSRNS 632
Cdd:pfam15351  695 GHQYRDQQTQTSFTEESKSSQLLPAEKPGGSSNAAPTPKCLDPTASEAQTHTALASSDQNQRPSAPSLKGQMSLSPSSNS 774

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654  633 AFSRTSSTINQTSMPKGASGQLPS------ANPVPKPEVVKGESTvGQCNSTQLFGQFLLKPVSRRPWDLISQLESFNKE 706
Cdd:pfam15351  775 AFSRTSSSINQAPVPKAGQSQPCVdvrgrgASPVPRGEVVKGETT-GPCNSKQLFGQFLLKPVSRRPWDLISQLESFNKE 853

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654  707 LQEEEESHGVSSGGDSEDSEAE-QPEDCADSSAKTRG----HQETRREQRPAELALGEAGP-PGGRLGESQSRSKEPKPG 780
Cdd:pfam15351  854 LQEEEESSSSSSGSSSEDSEAEwQPEDCADSRPKSPGfredSQEMRVEQQPRRLVPEDPVFrSGRVKSKSESWSEEPKPG 933

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654  781 HPCARSQALGPSQEEDSRGVPVQWGHGNLSAEQKSQEALNGMCERDISPRPVSRIA---PVDTQAASLFCLAEPRGSQEL 857
Cdd:pfam15351  934 HPCACPQSPGPSQVEDGRGEPFLSADGSLITEKRKQEVGNRINELAVSPGPVKRITssrSSDTKPVPPSYPAELREPQES 1013

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654  858 TKVNDALGSVELGRETPIRVDNGGDTEVLPCvlPPLADRCRGLSTPNFPSLELTLGQEQRAYKSE-CQGLDNTVEVLPSE 936
Cdd:pfam15351 1014 QKLPDALSSVQLSKAAPPRAGGGEERGTAVP--LSLASKSRGLSAPDLRSVGLTPGQEQSASKLDgSLGEASAIEIPPNE 1091

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654  937 SLQERAERILGIEVAVESLLPGARRTEQSQLPKPGTSACSPRSSREDSQPSSASPEDPTVATDAFYGRRKCGWTESPLFV 1016
Cdd:pfam15351 1092 SLQARAARILGIEVAVESLLPGARRTGQSQPPEPDGSACSPESPREESVSSSAPPDGPTVSTDAFYGRRKCGWTESPLFV 1171

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654 1017 GER-----APQAAVCSDVDGFPTSQATSPEP-----------EKKKEAKPPFKSTLFHFMEKSTNVVGPEKRLRNSSNVI 1080
Cdd:pfam15351 1172 GERdsarrAPQASEHSGVDGVVPSQAPSPEPqpsplesksfeQKDVETKPPFRSTLFHFIERTPSVAGSEKRLRSTSKVI 1251

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654 1081 ESSQGKLVSLPKRADSARLVRMREVNSLSQMRCLSSKSADSMEEPDPLKVIKSSAWPSEGLTSPSGKDQAWQAEYLPSVS 1160
Cdd:pfam15351 1252 ESLQEKLASPPRRADPDRLMRMKEVSSVSRMRLLSSRSADSGEEAEELKAERGQAGQPGGPVSLNGGDRARKAGHSLSVS 1331

                         1210      1220
                   ....*....|....*....|....*.
gi 1958734654 1161 Q-----NENGHPEVIREKMSDQDLWC 1181
Cdd:pfam15351 1332 KgiislEENGHPAAQREKNGDQDFWC 1357
 
Name Accession Description Interval E-value
JCAD pfam15351
Junctional protein associated with coronary artery disease; JCAD is a component of ...
 1-1181 0e+00

Junctional protein associated with coronary artery disease; JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells. The cell-cell or adherens junction is an adhesion complex that plays a crucial role in the organization and function of epithelial and endothelial cellular sheets. These junctions join the actin cytoskeleton to the plasma membrane to form adhesive contacts between cells or between cells and extracellular matrix. The junctions also mediate both cell adhesion and cell-signalling. JCAD localizes close to the apical membrane in epithelial cells. This family is found in eukaryotes.


Pssm-ID: 434658  Cd Length: 1358  Bit Score: 1593.61  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654    1 MAQAHSLPIHVRESPWEVARRTEHVMKNALWEAELRMPTPAKWQDMTLESWKQPRKLGRQASDGDGQKRsqerFEDLYQF 80
Cdd:pfam15351  140 MAQAHSLPVHVREGPWEVGGRTEHVMKKAVWEEELRMSGPAKWQNVSLESWNQPRKLGRQMSDGDGEKL----FQDLYPF 215

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654   81 VHGEHMLTSQNRKKSQSLPRALSPKSLNFTEIPVPLHDGHITGVPKVPPYPPSCPPPLEPTRNLEKTSSSGPFPRPKFGK 160
Cdd:pfam15351  216 IQGEHVLTSQNKGKSQSLPRVLSPESLSCMEIPIPLNDGHLPGVPKMPPYPPNCAPNLESTRNPEKGGSSAPLPRPKFGR 295

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654  161 PLKTPCHGSQPQPRG---EGGFQDHQHRDPRGCHPTRSKDPGHELGMLDTGLEPPVYVPPPSYRSPPQHIPNPYLEDPIP 237
Cdd:pfam15351  296 PLKPPSYESHQQSRGgveNSDYQDSQQADLCVSYLTRTSDPRQELCAPDPGLEPPVYVPPPSYRSPPQHIPNPYLEDAVP 375

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654  238 RHVSSSQSQQQQLPEKPEADCLLPSGSLAARDLYNAMPGSPPPGPPPHPYpIATHGDSIQYIPFDDPRIRHIKLAQPPEF 317
Cdd:pfam15351  376 RHVSGGHSQQQHPTEKPGASCQLPSGSLGTGNEYGASPRSPRGLPPHPRP-VTAYDGSVQYIPFDDPRIRHIKLAQPQGF 454

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654  318 YEEARLEDTSYNSGFIATQEPALGKRQYNDALSAPRGPILPPVNERGSAFAHSSPQWLQGQLPMASEPGGFPGQTEHHGM 397
Cdd:pfam15351  455 CEETKLDDKSYSSGPVTAQEPARGEMQHDGAVLNPQSLTPPSGSERGPAFADPSPRWLWGQLPRDGENGGFPDQRDHCVV 534

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654  398 RGLTADVRDSK---VESHASSPQPQSEGTCRTHTKLRKFETGIQSRKSSK-KSNATIFCLVSVPVKSESLVPDTDTNNND 473
Cdd:pfam15351  535 RGQWPDVRGSQhghAEGQVSSPSPQGESTCETQTKLKKFETGIQTKKSSKkKMNETIFCLVSIPVKSESHLPDTDTNNND 614

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654  474 LKLGADKNHGLYQGPALEEQSLLSMSSTDLELQALMGSMAWRRTSPRQVLGESE-DGQTDDPRTLHLIKPRELRASGSWP 552
Cdd:pfam15351  615 LKQSADKKNGLDKSGALQEQSLLSMSSTDLELQALTGSMAGRTELQKQDLGEPEeDKQTNDLRFIHPAKHRELKYSGSWP 694

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654  553 GHQYRDQQTQTSFPEDSKSSQLLPATKPGEASNAALTPTCPDDTASEVHLHAALASSDPSQKPSVPHLRGQMSLSPSRNS 632
Cdd:pfam15351  695 GHQYRDQQTQTSFTEESKSSQLLPAEKPGGSSNAAPTPKCLDPTASEAQTHTALASSDQNQRPSAPSLKGQMSLSPSSNS 774

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654  633 AFSRTSSTINQTSMPKGASGQLPS------ANPVPKPEVVKGESTvGQCNSTQLFGQFLLKPVSRRPWDLISQLESFNKE 706
Cdd:pfam15351  775 AFSRTSSSINQAPVPKAGQSQPCVdvrgrgASPVPRGEVVKGETT-GPCNSKQLFGQFLLKPVSRRPWDLISQLESFNKE 853

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654  707 LQEEEESHGVSSGGDSEDSEAE-QPEDCADSSAKTRG----HQETRREQRPAELALGEAGP-PGGRLGESQSRSKEPKPG 780
Cdd:pfam15351  854 LQEEEESSSSSSGSSSEDSEAEwQPEDCADSRPKSPGfredSQEMRVEQQPRRLVPEDPVFrSGRVKSKSESWSEEPKPG 933

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654  781 HPCARSQALGPSQEEDSRGVPVQWGHGNLSAEQKSQEALNGMCERDISPRPVSRIA---PVDTQAASLFCLAEPRGSQEL 857
Cdd:pfam15351  934 HPCACPQSPGPSQVEDGRGEPFLSADGSLITEKRKQEVGNRINELAVSPGPVKRITssrSSDTKPVPPSYPAELREPQES 1013

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654  858 TKVNDALGSVELGRETPIRVDNGGDTEVLPCvlPPLADRCRGLSTPNFPSLELTLGQEQRAYKSE-CQGLDNTVEVLPSE 936
Cdd:pfam15351 1014 QKLPDALSSVQLSKAAPPRAGGGEERGTAVP--LSLASKSRGLSAPDLRSVGLTPGQEQSASKLDgSLGEASAIEIPPNE 1091

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654  937 SLQERAERILGIEVAVESLLPGARRTEQSQLPKPGTSACSPRSSREDSQPSSASPEDPTVATDAFYGRRKCGWTESPLFV 1016
Cdd:pfam15351 1092 SLQARAARILGIEVAVESLLPGARRTGQSQPPEPDGSACSPESPREESVSSSAPPDGPTVSTDAFYGRRKCGWTESPLFV 1171

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654 1017 GER-----APQAAVCSDVDGFPTSQATSPEP-----------EKKKEAKPPFKSTLFHFMEKSTNVVGPEKRLRNSSNVI 1080
Cdd:pfam15351 1172 GERdsarrAPQASEHSGVDGVVPSQAPSPEPqpsplesksfeQKDVETKPPFRSTLFHFIERTPSVAGSEKRLRSTSKVI 1251

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654 1081 ESSQGKLVSLPKRADSARLVRMREVNSLSQMRCLSSKSADSMEEPDPLKVIKSSAWPSEGLTSPSGKDQAWQAEYLPSVS 1160
Cdd:pfam15351 1252 ESLQEKLASPPRRADPDRLMRMKEVSSVSRMRLLSSRSADSGEEAEELKAERGQAGQPGGPVSLNGGDRARKAGHSLSVS 1331

                         1210      1220
                   ....*....|....*....|....*.
gi 1958734654 1161 Q-----NENGHPEVIREKMSDQDLWC 1181
Cdd:pfam15351 1332 KgiislEENGHPAAQREKNGDQDFWC 1357
 
Name Accession Description Interval E-value
JCAD pfam15351
Junctional protein associated with coronary artery disease; JCAD is a component of ...
 1-1181 0e+00

Junctional protein associated with coronary artery disease; JCAD is a component of VE-cadherin-based cell-cell junctions in endothelial cells. The cell-cell or adherens junction is an adhesion complex that plays a crucial role in the organization and function of epithelial and endothelial cellular sheets. These junctions join the actin cytoskeleton to the plasma membrane to form adhesive contacts between cells or between cells and extracellular matrix. The junctions also mediate both cell adhesion and cell-signalling. JCAD localizes close to the apical membrane in epithelial cells. This family is found in eukaryotes.


Pssm-ID: 434658  Cd Length: 1358  Bit Score: 1593.61  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654    1 MAQAHSLPIHVRESPWEVARRTEHVMKNALWEAELRMPTPAKWQDMTLESWKQPRKLGRQASDGDGQKRsqerFEDLYQF 80
Cdd:pfam15351  140 MAQAHSLPVHVREGPWEVGGRTEHVMKKAVWEEELRMSGPAKWQNVSLESWNQPRKLGRQMSDGDGEKL----FQDLYPF 215

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654   81 VHGEHMLTSQNRKKSQSLPRALSPKSLNFTEIPVPLHDGHITGVPKVPPYPPSCPPPLEPTRNLEKTSSSGPFPRPKFGK 160
Cdd:pfam15351  216 IQGEHVLTSQNKGKSQSLPRVLSPESLSCMEIPIPLNDGHLPGVPKMPPYPPNCAPNLESTRNPEKGGSSAPLPRPKFGR 295

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654  161 PLKTPCHGSQPQPRG---EGGFQDHQHRDPRGCHPTRSKDPGHELGMLDTGLEPPVYVPPPSYRSPPQHIPNPYLEDPIP 237
Cdd:pfam15351  296 PLKPPSYESHQQSRGgveNSDYQDSQQADLCVSYLTRTSDPRQELCAPDPGLEPPVYVPPPSYRSPPQHIPNPYLEDAVP 375

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654  238 RHVSSSQSQQQQLPEKPEADCLLPSGSLAARDLYNAMPGSPPPGPPPHPYpIATHGDSIQYIPFDDPRIRHIKLAQPPEF 317
Cdd:pfam15351  376 RHVSGGHSQQQHPTEKPGASCQLPSGSLGTGNEYGASPRSPRGLPPHPRP-VTAYDGSVQYIPFDDPRIRHIKLAQPQGF 454

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654  318 YEEARLEDTSYNSGFIATQEPALGKRQYNDALSAPRGPILPPVNERGSAFAHSSPQWLQGQLPMASEPGGFPGQTEHHGM 397
Cdd:pfam15351  455 CEETKLDDKSYSSGPVTAQEPARGEMQHDGAVLNPQSLTPPSGSERGPAFADPSPRWLWGQLPRDGENGGFPDQRDHCVV 534

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654  398 RGLTADVRDSK---VESHASSPQPQSEGTCRTHTKLRKFETGIQSRKSSK-KSNATIFCLVSVPVKSESLVPDTDTNNND 473
Cdd:pfam15351  535 RGQWPDVRGSQhghAEGQVSSPSPQGESTCETQTKLKKFETGIQTKKSSKkKMNETIFCLVSIPVKSESHLPDTDTNNND 614

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654  474 LKLGADKNHGLYQGPALEEQSLLSMSSTDLELQALMGSMAWRRTSPRQVLGESE-DGQTDDPRTLHLIKPRELRASGSWP 552
Cdd:pfam15351  615 LKQSADKKNGLDKSGALQEQSLLSMSSTDLELQALTGSMAGRTELQKQDLGEPEeDKQTNDLRFIHPAKHRELKYSGSWP 694

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654  553 GHQYRDQQTQTSFPEDSKSSQLLPATKPGEASNAALTPTCPDDTASEVHLHAALASSDPSQKPSVPHLRGQMSLSPSRNS 632
Cdd:pfam15351  695 GHQYRDQQTQTSFTEESKSSQLLPAEKPGGSSNAAPTPKCLDPTASEAQTHTALASSDQNQRPSAPSLKGQMSLSPSSNS 774

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654  633 AFSRTSSTINQTSMPKGASGQLPS------ANPVPKPEVVKGESTvGQCNSTQLFGQFLLKPVSRRPWDLISQLESFNKE 706
Cdd:pfam15351  775 AFSRTSSSINQAPVPKAGQSQPCVdvrgrgASPVPRGEVVKGETT-GPCNSKQLFGQFLLKPVSRRPWDLISQLESFNKE 853

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654  707 LQEEEESHGVSSGGDSEDSEAE-QPEDCADSSAKTRG----HQETRREQRPAELALGEAGP-PGGRLGESQSRSKEPKPG 780
Cdd:pfam15351  854 LQEEEESSSSSSGSSSEDSEAEwQPEDCADSRPKSPGfredSQEMRVEQQPRRLVPEDPVFrSGRVKSKSESWSEEPKPG 933

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654  781 HPCARSQALGPSQEEDSRGVPVQWGHGNLSAEQKSQEALNGMCERDISPRPVSRIA---PVDTQAASLFCLAEPRGSQEL 857
Cdd:pfam15351  934 HPCACPQSPGPSQVEDGRGEPFLSADGSLITEKRKQEVGNRINELAVSPGPVKRITssrSSDTKPVPPSYPAELREPQES 1013

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654  858 TKVNDALGSVELGRETPIRVDNGGDTEVLPCvlPPLADRCRGLSTPNFPSLELTLGQEQRAYKSE-CQGLDNTVEVLPSE 936
Cdd:pfam15351 1014 QKLPDALSSVQLSKAAPPRAGGGEERGTAVP--LSLASKSRGLSAPDLRSVGLTPGQEQSASKLDgSLGEASAIEIPPNE 1091

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654  937 SLQERAERILGIEVAVESLLPGARRTEQSQLPKPGTSACSPRSSREDSQPSSASPEDPTVATDAFYGRRKCGWTESPLFV 1016
Cdd:pfam15351 1092 SLQARAARILGIEVAVESLLPGARRTGQSQPPEPDGSACSPESPREESVSSSAPPDGPTVSTDAFYGRRKCGWTESPLFV 1171

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654 1017 GER-----APQAAVCSDVDGFPTSQATSPEP-----------EKKKEAKPPFKSTLFHFMEKSTNVVGPEKRLRNSSNVI 1080
Cdd:pfam15351 1172 GERdsarrAPQASEHSGVDGVVPSQAPSPEPqpsplesksfeQKDVETKPPFRSTLFHFIERTPSVAGSEKRLRSTSKVI 1251

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958734654 1081 ESSQGKLVSLPKRADSARLVRMREVNSLSQMRCLSSKSADSMEEPDPLKVIKSSAWPSEGLTSPSGKDQAWQAEYLPSVS 1160
Cdd:pfam15351 1252 ESLQEKLASPPRRADPDRLMRMKEVSSVSRMRLLSSRSADSGEEAEELKAERGQAGQPGGPVSLNGGDRARKAGHSLSVS 1331

                         1210      1220
                   ....*....|....*....|....*.
gi 1958734654 1161 Q-----NENGHPEVIREKMSDQDLWC 1181
Cdd:pfam15351 1332 KgiislEENGHPAAQREKNGDQDFWC 1357
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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