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Conserved domains on  [gi|1958670568|ref|XP_038946006|]
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transducin beta-like protein 2 isoform X1 [Rattus norvegicus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
3-302 2.58e-36

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.42  E-value: 2.58e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670568   3 FSSNGKYLATCADDRTVRIWSTKDflQREHRSMRAnveldHATLVR---FSPDCRaFIVWLANGDTLRVFKMTKREDGgF 79
Cdd:COG2319   128 FSPDGKTLASGSADGTVRLWDLAT--GKLLRTLTG-----HSGAVTsvaFSPDGK-LLASGSDDGTVRLWDLATGKLL-R 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670568  80 TFTAtpedfpkkHKAPIINIGIADTGKFIMTASSDTTVLIWNLK-GQVLSTINTNQMNNSHAVISPCSRFVGSCGFTPDV 158
Cdd:COG2319   199 TLTG--------HTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670568 159 KVWEVcfgkkgEFQEVLRafELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTDveykkqqDPYLLRTgrFEEASTMP 238
Cdd:COG2319   271 RLWDL------ATGELLR--TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-------TGKLLRT--LTGHTGAV 333

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958670568 239 CRLALSPDTHVLALATG-TSIHLFNTRRGEKEEYFEcVHGECIADLTFDITGRFLASCG-DRAVRL 302
Cdd:COG2319   334 RSVAFSPDGKTLASGSDdGTVRLWDLATGELLRTLT-GHTGAVTSVAFSPDGRTLASGSaDGTVRL 398
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
3-302 2.58e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.42  E-value: 2.58e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670568   3 FSSNGKYLATCADDRTVRIWSTKDflQREHRSMRAnveldHATLVR---FSPDCRaFIVWLANGDTLRVFKMTKREDGgF 79
Cdd:COG2319   128 FSPDGKTLASGSADGTVRLWDLAT--GKLLRTLTG-----HSGAVTsvaFSPDGK-LLASGSDDGTVRLWDLATGKLL-R 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670568  80 TFTAtpedfpkkHKAPIINIGIADTGKFIMTASSDTTVLIWNLK-GQVLSTINTNQMNNSHAVISPCSRFVGSCGFTPDV 158
Cdd:COG2319   199 TLTG--------HTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670568 159 KVWEVcfgkkgEFQEVLRafELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTDveykkqqDPYLLRTgrFEEASTMP 238
Cdd:COG2319   271 RLWDL------ATGELLR--TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-------TGKLLRT--LTGHTGAV 333

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958670568 239 CRLALSPDTHVLALATG-TSIHLFNTRRGEKEEYFEcVHGECIADLTFDITGRFLASCG-DRAVRL 302
Cdd:COG2319   334 RSVAFSPDGKTLASGSDdGTVRLWDLATGELLRTLT-GHTGAVTSVAFSPDGRTLASGSaDGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-303 5.18e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.02  E-value: 5.18e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670568   1 MDFSSNGKYLATCADDRTVRIWSTKDFLQrehrsMRANVELDHA-TLVRFSPDcRAFIVWLANGDTLRVFKMTKREDGgF 79
Cdd:cd00200    15 VAFSPDGKLLATGSGDGTIKVWDLETGEL-----LRTLKGHTGPvRDVAASAD-GTYLASGSSDKTIRLWDLETGECV-R 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670568  80 TFTAtpedfpkkHKAPIINIGIADTGKFIMTASSDTTVLIWNL-KGQVLSTINTNQMNNSHAVISPCSRFVGSCGFTPDV 158
Cdd:cd00200    88 TLTG--------HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVeTGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670568 159 KVWEVcfgKKGEFQEVLrafelKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTDveyKKQQdpylLRTGRFEEAStmP 238
Cdd:cd00200   160 KLWDL---RTGKCVATL-----TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---TGKC----LGTLRGHENG--V 222

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958670568 239 CRLALSPDTHVLALATGT-SIHLFNTRRGEKEEYFECVHGECIAdLTFDITGRFLASCG-DRAVRLF 303
Cdd:cd00200   223 NSVAFSPDGYLLASGSEDgTIRVWDLRTGECVQTLSGHTNSVTS-LAWSPDGKRLASGSaDGTIRIW 288
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 178-212 5.02e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 5.02e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958670568  178 FELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWD 212
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
179-212 1.25e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.25e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1958670568 179 ELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWD 212
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
3-302 2.58e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.42  E-value: 2.58e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670568   3 FSSNGKYLATCADDRTVRIWSTKDflQREHRSMRAnveldHATLVR---FSPDCRaFIVWLANGDTLRVFKMTKREDGgF 79
Cdd:COG2319   128 FSPDGKTLASGSADGTVRLWDLAT--GKLLRTLTG-----HSGAVTsvaFSPDGK-LLASGSDDGTVRLWDLATGKLL-R 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670568  80 TFTAtpedfpkkHKAPIINIGIADTGKFIMTASSDTTVLIWNLK-GQVLSTINTNQMNNSHAVISPCSRFVGSCGFTPDV 158
Cdd:COG2319   199 TLTG--------HTGAVRSVAFSPDGKLLASGSADGTVRLWDLAtGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTV 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670568 159 KVWEVcfgkkgEFQEVLRafELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTDveykkqqDPYLLRTgrFEEASTMP 238
Cdd:COG2319   271 RLWDL------ATGELLR--TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-------TGKLLRT--LTGHTGAV 333

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1958670568 239 CRLALSPDTHVLALATG-TSIHLFNTRRGEKEEYFEcVHGECIADLTFDITGRFLASCG-DRAVRL 302
Cdd:COG2319   334 RSVAFSPDGKTLASGSDdGTVRLWDLATGELLRTLT-GHTGAVTSVAFSPDGRTLASGSaDGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
3-214 1.29e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 114.62  E-value: 1.29e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670568   3 FSSNGKYLATCADDRTVRIWSTKDflQREHRSMRANVELDHAtlVRFSPDCRafivWLANGD---TLRVFKMTkredggf 79
Cdd:COG2319   212 FSPDGKLLASGSADGTVRLWDLAT--GKLLRTLTGHSGSVRS--VAFSPDGR----LLASGSadgTVRLWDLA------- 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670568  80 tfTATPEDFPKKHKAPIINIGIADTGKFIMTASSDTTVLIWNLK-GQVLSTINTNQMNNSHAVISPCSRFVGSCGFTPDV 158
Cdd:COG2319   277 --TGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTV 354

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1958670568 159 KVWEVcfgkkgEFQEVLRafELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTD 214
Cdd:COG2319   355 RLWDL------ATGELLR--TLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
2-308 6.68e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.53  E-value: 6.68e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670568   2 DFSSNGKYLATCADDRTVRIWstkdFLQREHRSMRANVELDHATLVRFSPDCRAFIVWLANGDTLRVFKMTKREDGGFTF 81
Cdd:COG2319     1 ALSADGAALAAASADLALALL----AAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670568  82 tatpedfpkkHKAPIINIGIADTGKFIMTASSDTTVLIWNLKGQVLSTINTNQMNNSHAV-ISPCSRFVGSCGFTPDVKV 160
Cdd:COG2319    77 ----------HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVaFSPDGKTLASGSADGTVRL 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670568 161 WEVCFGKkgefqevlRAFELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTDveykkqqDPYLLRTgrFEEASTMPCR 240
Cdd:COG2319   147 WDLATGK--------LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA-------TGKLLRT--LTGHTGAVRS 209

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670568 241 LALSPDTHVLALATG-TSIHLFNTRRGEKEEYFEcVHGECIADLTFDITGRFLASCG-DRAVRLFHNTPG 308
Cdd:COG2319   210 VAFSPDGKLLASGSAdGTVRLWDLATGKLLRTLT-GHSGSVRSVAFSPDGRLLASGSaDGTVRLWDLATG 278
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-303 5.18e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.02  E-value: 5.18e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670568   1 MDFSSNGKYLATCADDRTVRIWSTKDFLQrehrsMRANVELDHA-TLVRFSPDcRAFIVWLANGDTLRVFKMTKREDGgF 79
Cdd:cd00200    15 VAFSPDGKLLATGSGDGTIKVWDLETGEL-----LRTLKGHTGPvRDVAASAD-GTYLASGSSDKTIRLWDLETGECV-R 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670568  80 TFTAtpedfpkkHKAPIINIGIADTGKFIMTASSDTTVLIWNL-KGQVLSTINTNQMNNSHAVISPCSRFVGSCGFTPDV 158
Cdd:cd00200    88 TLTG--------HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVeTGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670568 159 KVWEVcfgKKGEFQEVLrafelKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTDveyKKQQdpylLRTGRFEEAStmP 238
Cdd:cd00200   160 KLWDL---RTGKCVATL-----TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---TGKC----LGTLRGHENG--V 222

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1958670568 239 CRLALSPDTHVLALATGT-SIHLFNTRRGEKEEYFECVHGECIAdLTFDITGRFLASCG-DRAVRLF 303
Cdd:cd00200   223 NSVAFSPDGYLLASGSEDgTIRVWDLRTGECVQTLSGHTNSVTS-LAWSPDGKRLASGSaDGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-212 8.06e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.86  E-value: 8.06e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670568   1 MDFSSNGKYLATCADDRTVRIWSTKDFLQRehRSMRANveLDHATLVRFSPDcRAFI----------VWlaNGDTLRVFK 70
Cdd:cd00200    99 VAFSPDGRILSSSSRDKTIKVWDVETGKCL--TTLRGH--TDWVNSVAFSPD-GTFVasssqdgtikLW--DLRTGKCVA 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670568  71 mtkredggfTFTAtpedfpkkHKAPIINIGIADTGKFIMTASSDTTVLIWNLK-GQVLSTINTNQMNNSHAVISPCSRFV 149
Cdd:cd00200   172 ---------TLTG--------HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLStGKCLGTLRGHENGVNSVAFSPDGYLL 234

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1958670568 150 GSCGFTPDVKVWEVCFGKkgefqevlRAFELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWD 212
Cdd:cd00200   235 ASGSEDGTIRVWDLRTGE--------CVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 90-303 6.72e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.77  E-value: 6.72e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670568  90 KKHKAPIINIGIADTGKFIMTASSDTTVLIWNLKGQVLSTINTNQMNNSHAVI-SPCSRFVGSCGFTPDVKVWEVcfgkk 168
Cdd:cd00200     6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAaSADGTYLASGSSDKTIRLWDL----- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670568 169 gEFQEVLRafELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTDveykkqqDPYLLRTGRFEEASTMpcRLALSPDTH 248
Cdd:cd00200    81 -ETGECVR--TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE-------TGKCLTTLRGHTDWVN--SVAFSPDGT 148

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1958670568 249 VLALATG-TSIHLFNTRRGEKEEYFEcVHGECIADLTFDITG-RFLASCGDRAVRLF 303
Cdd:cd00200   149 FVASSSQdGTIKLWDLRTGKCVATLT-GHTGEVNSVAFSPDGeKLLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
3-124 5.21e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.47  E-value: 5.21e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670568   3 FSSNGKYLATCADDRTVRIWSTKDflQREHRSMRANVelDHATLVRFSPDCRaFIVWLANGDTLRVFKMTKREDGGfTFT 82
Cdd:COG2319   296 FSPDGKLLASGSDDGTVRLWDLAT--GKLLRTLTGHT--GAVRSVAFSPDGK-TLASGSDDGTVRLWDLATGELLR-TLT 369

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1958670568  83 AtpedfpkkHKAPIINIGIADTGKFIMTASSDTTVLIWNLKG 124
Cdd:COG2319   370 G--------HTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 178-308 7.06e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 56.19  E-value: 7.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1958670568 178 FELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWDTDveykkQQDPYLLRTGRFEEASTmpcrLALSPDTHVLALATGTS 257
Cdd:cd00200     3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----TGELLRTLKGHTGPVRD----VAASADGTYLASGSSDK 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1958670568 258 -IHLFNTRRGEKEEYFECvHGECIADLTFDITGRFLASCG-DRAVRLFHNTPG 308
Cdd:cd00200    74 tIRLWDLETGECVRTLTG-HTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETG 125
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 178-212 5.02e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 5.02e-08
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1958670568  178 FELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWD 212
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
179-212 1.25e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 1.25e-06
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1958670568 179 ELKGHSASVHSFAFSNDSRRMASVSKDGTWKLWD 212
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1-23 1.77e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 1.77e-04
                           10        20
                   ....*....|....*....|...
gi 1958670568    1 MDFSSNGKYLATCADDRTVRIWS 23
Cdd:smart00320  18 VAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
1-23 2.93e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 2.93e-04
                          10        20
                  ....*....|....*....|...
gi 1958670568   1 MDFSSNGKYLATCADDRTVRIWS 23
Cdd:pfam00400  17 LAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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