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Conserved domains on  [gi|1955846656|ref|XP_038881327|]
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uncharacterized protein LOC120072874 [Benincasa hispida]

Protein Classification

PDDEXK-like family protein( domain architecture ID 10520365)

PDDEXK-like family protein is a distant plant homolog of the PD-(D/E)XK nuclease superfamily; its function is unknown

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PDDEXK_6 pfam04720
PDDEXK-like family of unknown function; PDDEXK_6 is a family of plant proteins that are ...
 35-230 5.79e-78

PDDEXK-like family of unknown function; PDDEXK_6 is a family of plant proteins that are distant homologs of the PD-(D/E)XK nuclease superfamily. The core structure is retained, as alpha-beta-beta-beta-alpha-beta. It retains the characteriztic PDDEXK motifs II and III in modified forms - xDxxx motif located in the second core beta-strand, where x is any hydrophobic residue, and a D/E)X(D/N/S/C/G) pattern. The missing positively charged residue in motif III is possibly replaced by a conserved arginine in motif IV located in the proceeding alpha-helix. The family is not in general fused with any other domains, so its function cannot be predicted.


:

Pssm-ID: 428087  Cd Length: 215  Bit Score: 235.55  E-value: 5.79e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955846656  35 LVKSFIEKGDI-------KIKEGEKEDSYTEESD-GFSFDSDAEAIkLRNLFGSLDDKNGEIRIEAEQALK------PVG 100
Cdd:pfam04720   1 MVQGFLEEGEGssgekesGGRCNCFNGENSDDSDdDFDFWEDAAEL-LKSLLLCTSSAERNLLADVSEAVEkaakngKRK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955846656 101 GRSFPGIKRQLMAHLRRKGFDAGLCKSKMEKLRSFPAGDHEYIDVNF------GGNRYIVEIFLAREFEIARPTSKYISL 174
Cdd:pfam04720  80 DGCRSCLRRAVVDLLRELGYDAAICKSKWEKSPSIPAGEHEYIDVVVnasskkGEGRYIVDLDFRSEFEIARPTKEYNAL 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1955846656 175 LNIFPEIFVGNLEELKQVVKLMCSAMKESMKKRNMHVPPWRRNGYMQAKWFGSYKR 230
Cdd:pfam04720 160 LQSLPEVFVGKSERLKQIVRIMCDAAKRSLKKKGMHLPPWRKHEYMQAKWLGPYER 215
 
Name Accession Description Interval E-value
PDDEXK_6 pfam04720
PDDEXK-like family of unknown function; PDDEXK_6 is a family of plant proteins that are ...
 35-230 5.79e-78

PDDEXK-like family of unknown function; PDDEXK_6 is a family of plant proteins that are distant homologs of the PD-(D/E)XK nuclease superfamily. The core structure is retained, as alpha-beta-beta-beta-alpha-beta. It retains the characteriztic PDDEXK motifs II and III in modified forms - xDxxx motif located in the second core beta-strand, where x is any hydrophobic residue, and a D/E)X(D/N/S/C/G) pattern. The missing positively charged residue in motif III is possibly replaced by a conserved arginine in motif IV located in the proceeding alpha-helix. The family is not in general fused with any other domains, so its function cannot be predicted.


Pssm-ID: 428087  Cd Length: 215  Bit Score: 235.55  E-value: 5.79e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955846656  35 LVKSFIEKGDI-------KIKEGEKEDSYTEESD-GFSFDSDAEAIkLRNLFGSLDDKNGEIRIEAEQALK------PVG 100
Cdd:pfam04720   1 MVQGFLEEGEGssgekesGGRCNCFNGENSDDSDdDFDFWEDAAEL-LKSLLLCTSSAERNLLADVSEAVEkaakngKRK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955846656 101 GRSFPGIKRQLMAHLRRKGFDAGLCKSKMEKLRSFPAGDHEYIDVNF------GGNRYIVEIFLAREFEIARPTSKYISL 174
Cdd:pfam04720  80 DGCRSCLRRAVVDLLRELGYDAAICKSKWEKSPSIPAGEHEYIDVVVnasskkGEGRYIVDLDFRSEFEIARPTKEYNAL 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1955846656 175 LNIFPEIFVGNLEELKQVVKLMCSAMKESMKKRNMHVPPWRRNGYMQAKWFGSYKR 230
Cdd:pfam04720 160 LQSLPEVFVGKSERLKQIVRIMCDAAKRSLKKKGMHLPPWRKHEYMQAKWLGPYER 215
A_thal_3542 TIGR01615
uncharacterized plant-specific domain TIGR01615; This model represents a domain found toward ...
 108-232 5.45e-57

uncharacterized plant-specific domain TIGR01615; This model represents a domain found toward the C-terminus of a number of uncharacterized plant proteins. The domain is strongly conserved (greater than 30 % sequence identity between most pairs of members) but flanked by highly divergent regions including stretches of low-complexity sequence.


Pssm-ID: 273718  Cd Length: 131  Bit Score: 179.17  E-value: 5.45e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955846656 108 KRQLMAHLRRKGFDAGLCKSKMEKLRSFPAGDHEYIDVNFG------GNRYIVEIFLAREFEIARPTSKYISLLNIFPEI 181
Cdd:TIGR01615   1 RRIVMSLLRSLGYDAAICKSKWDSSGDIPAGKYEYIDVVDGdgskkqEMRVIIDLDFRSEFEIARPTEEYKRLLESLPEV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1955846656 182 FVGNLEELKQVVKLMCSAMKESMKKRNMHVPPWRRNGYMQAKWFGSYKRTT 232
Cdd:TIGR01615  81 FVGTTERLRQLVRLMCDAAKKSLKKKGMPLPPWRKNRYMQSKWLGPYKRTS 131
 
Name Accession Description Interval E-value
PDDEXK_6 pfam04720
PDDEXK-like family of unknown function; PDDEXK_6 is a family of plant proteins that are ...
 35-230 5.79e-78

PDDEXK-like family of unknown function; PDDEXK_6 is a family of plant proteins that are distant homologs of the PD-(D/E)XK nuclease superfamily. The core structure is retained, as alpha-beta-beta-beta-alpha-beta. It retains the characteriztic PDDEXK motifs II and III in modified forms - xDxxx motif located in the second core beta-strand, where x is any hydrophobic residue, and a D/E)X(D/N/S/C/G) pattern. The missing positively charged residue in motif III is possibly replaced by a conserved arginine in motif IV located in the proceeding alpha-helix. The family is not in general fused with any other domains, so its function cannot be predicted.


Pssm-ID: 428087  Cd Length: 215  Bit Score: 235.55  E-value: 5.79e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955846656  35 LVKSFIEKGDI-------KIKEGEKEDSYTEESD-GFSFDSDAEAIkLRNLFGSLDDKNGEIRIEAEQALK------PVG 100
Cdd:pfam04720   1 MVQGFLEEGEGssgekesGGRCNCFNGENSDDSDdDFDFWEDAAEL-LKSLLLCTSSAERNLLADVSEAVEkaakngKRK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955846656 101 GRSFPGIKRQLMAHLRRKGFDAGLCKSKMEKLRSFPAGDHEYIDVNF------GGNRYIVEIFLAREFEIARPTSKYISL 174
Cdd:pfam04720  80 DGCRSCLRRAVVDLLRELGYDAAICKSKWEKSPSIPAGEHEYIDVVVnasskkGEGRYIVDLDFRSEFEIARPTKEYNAL 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1955846656 175 LNIFPEIFVGNLEELKQVVKLMCSAMKESMKKRNMHVPPWRRNGYMQAKWFGSYKR 230
Cdd:pfam04720 160 LQSLPEVFVGKSERLKQIVRIMCDAAKRSLKKKGMHLPPWRKHEYMQAKWLGPYER 215
A_thal_3542 TIGR01615
uncharacterized plant-specific domain TIGR01615; This model represents a domain found toward ...
 108-232 5.45e-57

uncharacterized plant-specific domain TIGR01615; This model represents a domain found toward the C-terminus of a number of uncharacterized plant proteins. The domain is strongly conserved (greater than 30 % sequence identity between most pairs of members) but flanked by highly divergent regions including stretches of low-complexity sequence.


Pssm-ID: 273718  Cd Length: 131  Bit Score: 179.17  E-value: 5.45e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1955846656 108 KRQLMAHLRRKGFDAGLCKSKMEKLRSFPAGDHEYIDVNFG------GNRYIVEIFLAREFEIARPTSKYISLLNIFPEI 181
Cdd:TIGR01615   1 RRIVMSLLRSLGYDAAICKSKWDSSGDIPAGKYEYIDVVDGdgskkqEMRVIIDLDFRSEFEIARPTEEYKRLLESLPEV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1955846656 182 FVGNLEELKQVVKLMCSAMKESMKKRNMHVPPWRRNGYMQAKWFGSYKRTT 232
Cdd:TIGR01615  81 FVGTTERLRQLVRLMCDAAKKSLKKKGMPLPPWRKNRYMQSKWLGPYKRTS 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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