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Conserved domains on  [gi|195582801|ref|XP_002081214|]
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adenylate kinase isoenzyme 6 homolog [Drosophila simulans]

Protein Classification

AAA family ATPase( domain architecture ID 10591166)

AAA family ATPase similar to Bacillus subtilis tunicamycin resistance protein (TmrB), an ATP-binding membrane protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AAA_18 pfam13238
AAA domain;
12-132 2.61e-32

AAA domain;


:

Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 112.14  E-value: 2.61e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195582801   12 ILITGTPGAGKSYLCERIASELKFeWLDCSKIAKENNFVEEYDEEYD-CPILDEEKLMDHLE-----PLMAKGGN-VVEY 84
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSKRLGF-GDNVRDLALENGLVLGDDPETReSKRLDEDKLDRLLDlleenAALEEGGNlIIDG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 195582801   85 HGCDFFPERWFQAVFVV-TCPNTTIYDRLKERNYNEKKLTSNIECEIFG 132
Cdd:pfam13238  80 HLAELEPERAKDLVGIVlRASPEELLERLEKRGYEEAKIKENEEAEILG 128
 
Name Accession Description Interval E-value
AAA_18 pfam13238
AAA domain;
12-132 2.61e-32

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 112.14  E-value: 2.61e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195582801   12 ILITGTPGAGKSYLCERIASELKFeWLDCSKIAKENNFVEEYDEEYD-CPILDEEKLMDHLE-----PLMAKGGN-VVEY 84
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSKRLGF-GDNVRDLALENGLVLGDDPETReSKRLDEDKLDRLLDlleenAALEEGGNlIIDG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 195582801   85 HGCDFFPERWFQAVFVV-TCPNTTIYDRLKERNYNEKKLTSNIECEIFG 132
Cdd:pfam13238  80 HLAELEPERAKDLVGIVlRASPEELLERLEKRGYEEAKIKENEEAEILG 128
Fap7 COG1936
Broad-specificity NMP kinase [Nucleotide transport and metabolism];
12-150 6.67e-32

Broad-specificity NMP kinase [Nucleotide transport and metabolism];


Pssm-ID: 441539 [Multi-domain]  Cd Length: 173  Bit Score: 112.60  E-value: 6.67e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195582801  12 ILITGTPGAGKSYLCERIASELKFEWLDCSKIAKENNFVEEYDEEYDCPILDEEKLMDHLEPlMAKGGNVVEYHGCDFFP 91
Cdd:COG1936    3 IAITGTPGTGKTTVAKLLAERLGLEVIHLNDLVKEEGLYTEVDEERDSLVVDEDALAEELEE-LKEGDVIIEGHLAHLVD 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 195582801  92 -ERwfqaVFVVTCPNTTIYDRLKERNYNEKKLTSNIECEIFGTILEEARGSYKSDIVFEL 150
Cdd:COG1936   82 vDR----VIVLRCNPEVLEERLEERGYSEEKIRENVEAEALDVILSEAVERFGEEKVYEI 137
PRK03839 PRK03839
putative kinase; Provisional
 12-138 1.19e-13

putative kinase; Provisional


Pssm-ID: 179660  Cd Length: 180  Bit Score: 65.51  E-value: 1.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195582801  12 ILITGTPGAGKSYLCERIASELKFEWLDCSKIAKENNFVEEYDEEYDcpiLDEEKLMDHLEPLMaKGGNVV-EYHGCDFF 90
Cdd:PRK03839   3 IAITGTPGVGKTTVSKLLAEKLGYEYVDLTEFALKKGIGEEKDDEME---IDFDKLAYFIEEEF-KEKNVVlDGHLSHLL 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 195582801  91 PERWfqaVFVVTCPNTTIYDRLKERNYNEKKLTSNIECEIFGTILEEA 138
Cdd:PRK03839  79 PVDY---VIVLRAHPKIIKERLKERGYSKKKILENVEAELVDVCLCEA 123
MMAA-like cd03114
methylmalonic aciduria associated protein; Methylmalonyl Co-A mutase-associated GTPase MeaB ...
 14-33 2.29e-03

methylmalonic aciduria associated protein; Methylmalonyl Co-A mutase-associated GTPase MeaB and its human homolog, methylmalonic aciduria associated protein (MMAA) are metallochaperones that function as a G-protein chaperone that assists AdoCbl cofactor delivery to the methylmalonyl-CoA mutase (MCM) and reactivation of the enzyme during catalysis. A member of the family, Escherichia coli ArgK, was previously thought to be a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and ornithine (AO system) and lysine, arginine and ornithine (LAO) transport systems.


Pssm-ID: 349768  Cd Length: 252  Bit Score: 37.17  E-value: 2.29e-03
                         10        20
                 ....*....|....*....|
gi 195582801  14 ITGTPGAGKSYLCERIASEL 33
Cdd:cd03114   51 ITGPPGAGKSTLIEALGRLL 70
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 9-47 5.28e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 35.81  E-value: 5.28e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 195582801     9 KPNILITGTPGAGKSYLCERIASEL-----KFEWLDCSKIAKEN 47
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELgppggGVIYIDGEDILEEV 45
 
Name Accession Description Interval E-value
AAA_18 pfam13238
AAA domain;
12-132 2.61e-32

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 112.14  E-value: 2.61e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195582801   12 ILITGTPGAGKSYLCERIASELKFeWLDCSKIAKENNFVEEYDEEYD-CPILDEEKLMDHLE-----PLMAKGGN-VVEY 84
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSKRLGF-GDNVRDLALENGLVLGDDPETReSKRLDEDKLDRLLDlleenAALEEGGNlIIDG 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 195582801   85 HGCDFFPERWFQAVFVV-TCPNTTIYDRLKERNYNEKKLTSNIECEIFG 132
Cdd:pfam13238  80 HLAELEPERAKDLVGIVlRASPEELLERLEKRGYEEAKIKENEEAEILG 128
Fap7 COG1936
Broad-specificity NMP kinase [Nucleotide transport and metabolism];
12-150 6.67e-32

Broad-specificity NMP kinase [Nucleotide transport and metabolism];


Pssm-ID: 441539 [Multi-domain]  Cd Length: 173  Bit Score: 112.60  E-value: 6.67e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195582801  12 ILITGTPGAGKSYLCERIASELKFEWLDCSKIAKENNFVEEYDEEYDCPILDEEKLMDHLEPlMAKGGNVVEYHGCDFFP 91
Cdd:COG1936    3 IAITGTPGTGKTTVAKLLAERLGLEVIHLNDLVKEEGLYTEVDEERDSLVVDEDALAEELEE-LKEGDVIIEGHLAHLVD 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 195582801  92 -ERwfqaVFVVTCPNTTIYDRLKERNYNEKKLTSNIECEIFGTILEEARGSYKSDIVFEL 150
Cdd:COG1936   82 vDR----VIVLRCNPEVLEERLEERGYSEEKIRENVEAEALDVILSEAVERFGEEKVYEI 137
PRK03839 PRK03839
putative kinase; Provisional
 12-138 1.19e-13

putative kinase; Provisional


Pssm-ID: 179660  Cd Length: 180  Bit Score: 65.51  E-value: 1.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195582801  12 ILITGTPGAGKSYLCERIASELKFEWLDCSKIAKENNFVEEYDEEYDcpiLDEEKLMDHLEPLMaKGGNVV-EYHGCDFF 90
Cdd:PRK03839   3 IAITGTPGVGKTTVSKLLAEKLGYEYVDLTEFALKKGIGEEKDDEME---IDFDKLAYFIEEEF-KEKNVVlDGHLSHLL 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 195582801  91 PERWfqaVFVVTCPNTTIYDRLKERNYNEKKLTSNIECEIFGTILEEA 138
Cdd:PRK03839  79 PVDY---VIVLRAHPKIIKERLKERGYSKKKILENVEAELVDVCLCEA 123
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
12-116 6.86e-07

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 46.83  E-value: 6.86e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195582801  12 ILITGTPGAGKSYLCERIASELKFEWLD---------CSKIAKENNFVEEYDEEYDCpildeekLMDHLEPLMAKGGNVV 82
Cdd:COG0645    2 ILVCGLPGSGKSTLARALAERLGAVRLRsdvvrkrlfGAGLAPLERSPEATARTYAR-------LLALARELLAAGRSVI 74

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 195582801  83 eyhgCDF-FPER----WFQAV----------FVVTCPNTTIYDRLKERN 116
Cdd:COG0645   75 ----LDAtFLRRaqreAFRALaeeagapfvlIWLDAPEEVLRERLEARN 119
THEP1 COG1618
Nucleoside-triphosphatase THEP1 [Nucleotide transport and metabolism];
10-34 3.87e-04

Nucleoside-triphosphatase THEP1 [Nucleotide transport and metabolism];


Pssm-ID: 441225 [Multi-domain]  Cd Length: 175  Bit Score: 39.12  E-value: 3.87e-04
                         10        20
                 ....*....|....*....|....*
gi 195582801  10 PNILITGTPGAGKSYLCERIASELK 34
Cdd:COG1618    1 MKIFITGRPGVGKTTLLLKVVEELR 25
NTPase_1 pfam03266
NTPase; This domain is found across all species from bacteria to human, and the function was ...
 11-34 1.46e-03

NTPase; This domain is found across all species from bacteria to human, and the function was determined first in a hyperthermophilic bacterium to be an NTPase. The structure of one member-sequence represents a variation of the RecA fold, and implies that the function might be that of a DNA/RNA modifying enzyme. The sequence carries both a Walker A and Walker B motif which together are characteriztic of ATPases or GTPases. The protein exhibits an increased expression profile in human liver cholangiocarcinoma when compared to normal tissue.


Pssm-ID: 460869  Cd Length: 168  Bit Score: 37.61  E-value: 1.46e-03
                          10        20
                  ....*....|....*....|....
gi 195582801   11 NILITGTPGAGKSYLCERIASELK 34
Cdd:pfam03266   1 RIFITGPPGVGKTTLVLKVAELLK 24
MMAA-like cd03114
methylmalonic aciduria associated protein; Methylmalonyl Co-A mutase-associated GTPase MeaB ...
 14-33 2.29e-03

methylmalonic aciduria associated protein; Methylmalonyl Co-A mutase-associated GTPase MeaB and its human homolog, methylmalonic aciduria associated protein (MMAA) are metallochaperones that function as a G-protein chaperone that assists AdoCbl cofactor delivery to the methylmalonyl-CoA mutase (MCM) and reactivation of the enzyme during catalysis. A member of the family, Escherichia coli ArgK, was previously thought to be a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and ornithine (AO system) and lysine, arginine and ornithine (LAO) transport systems.


Pssm-ID: 349768  Cd Length: 252  Bit Score: 37.17  E-value: 2.29e-03
                         10        20
                 ....*....|....*....|
gi 195582801  14 ITGTPGAGKSYLCERIASEL 33
Cdd:cd03114   51 ITGPPGAGKSTLIEALGRLL 70
SK cd00464
Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic ...
 11-154 3.12e-03

Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids, p-aminobenzoic acid, folate and ubiquinone. Shikimate kinase catalyses the phosphorylation of the 3-hydroxyl group of shikimic acid using ATP.


Pssm-ID: 238260 [Multi-domain]  Cd Length: 154  Bit Score: 36.38  E-value: 3.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195582801  11 NILITGTPGAGKSYLCERIASELKFEWLDC-SKIAKENN-----FVEEYDEEYDC----PILDEEKLMDHLepLMAKGGN 80
Cdd:cd00464    1 NIVLIGMMGAGKTTVGRLLAKALGLPFVDLdELIEQRAGmsipeIFAEEGEEGFRelerEVLLLLLTKENA--VIATGGG 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195582801  81 VVEYhgcdffPE-RWFQA----VFVVTCPNTTIYDRLKERnyNEKKLTSNIECEIFGTILEEARGSYK--SDIVFELKGE 153
Cdd:cd00464   79 AVLR------EEnRRLLLengiVVWLDASPEELLERLARD--KTRPLLQDEDPERLRELLEEREPLYRevADLTIDTDEL 150


                 .
gi 195582801 154 T 154
Cdd:cd00464  151 S 151
Cytidylate_kin2 pfam13189
Cytidylate kinase-like family; This family includes enzymes related to cytidylate kinase.
 11-58 3.40e-03

Cytidylate kinase-like family; This family includes enzymes related to cytidylate kinase.


Pssm-ID: 433023 [Multi-domain]  Cd Length: 176  Bit Score: 36.45  E-value: 3.40e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 195582801   11 NILITGTPGAGKSYLCERIASELKFEWLDCS---KIAKENNFVEEYDEEYD 58
Cdd:pfam13189   1 VITISRQYGSGGTTIAKKLAEKLGYPFYDREildEIAKELGISEEEFELFD 51
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 9-34 4.36e-03

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 35.97  E-value: 4.36e-03
                         10        20
                 ....*....|....*....|....*.
gi 195582801   9 KPNILITGTPGAGKSYLCERIASELK 34
Cdd:cd00009   19 PKNLLLYGPPGTGKTTLARAIANELF 44
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 9-47 5.28e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 35.81  E-value: 5.28e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 195582801     9 KPNILITGTPGAGKSYLCERIASEL-----KFEWLDCSKIAKEN 47
Cdd:smart00382   2 GEVILIVGPPGSGKTTLARALARELgppggGVIYIDGEDILEEV 45
AAA_17 pfam13207
AAA domain;
15-115 6.30e-03

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 35.29  E-value: 6.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195582801   15 TGTPGAGKSYLCERIASELKFEWLDCS----KIAKENNFVEEYDEEYDCPILDEEKLMDHLEPLMAK----GGNVVEYHG 86
Cdd:pfam13207   1 TGVPGSGKTTQLKKLAEKLGFPHISAGdllrEEAKERGLVEDRDEMRKLPLEPQKELQKLAAERIAEeageGGVIVDGHP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 195582801   87 C-----DFFP--ERWFQ------AVFVVTCPNTTIYDRLKER 115
Cdd:pfam13207  81 RiktpaGYLPglPVEVLrelkpdAIILLEADPEEILERRLKD 122
RecA-like_Thep1 cd19482
RecA-like domain of the nucleoside-triphosphatase THEP1 family; This family represents the ...
 12-34 6.99e-03

RecA-like domain of the nucleoside-triphosphatase THEP1 family; This family represents the THEP1 family ATPase domain. It includes nucleoside-triphosphatase THEP 1 from Aquifex aeolicus (aaTHEP1) a nucleoside-phosphatase, with activity towards ATP, GTP, CTP, TTP and UTP; and which may hydrolyze nucleoside diphosphates with lower efficiency. The catalytic function of aaTHEP1 remains unclear, it may be a DNA/RNA modifying enzyme. Human THEP1 (hsTHEP1) may have a general function in many human tissues, as it is widely expressed in most examined tissues (such as in brain, heart, lymph node, skin, pancreas); it is especially highly expressed in embryonic and various tumor tissues. This family belongs to the RecA-like NTPase superfamily which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410890 [Multi-domain]  Cd Length: 164  Bit Score: 35.27  E-value: 6.99e-03
                         10        20
                 ....*....|....*....|...
gi 195582801  12 ILITGTPGAGKSYLCERIASELK 34
Cdd:cd19482    1 IFITGPPGVGKTTLVLKVAELLK 23
UMPK_like cd02028
Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the ...
 12-75 8.48e-03

Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK).


Pssm-ID: 238986 [Multi-domain]  Cd Length: 179  Bit Score: 35.36  E-value: 8.48e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195582801  12 ILITGTPGAGKSYLCERIASELKFEWLDCSKIAKENNFVEEYDEE-----YDCP-ILDEEKLMDHLEPLM 75
Cdd:cd02028    2 VGIAGPSGSGKTTFAKKLSNQLRVNGIGPVVISLDDYYVPRKTPRdedgnYDFEsILDLDLLNKNLHDLL 71
Udk COG0572
Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway ...
 12-84 9.74e-03

Uridine kinase [Nucleotide transport and metabolism]; Uridine kinase is part of the Pathway/BioSystem: Pyrimidine salvage


Pssm-ID: 440337 [Multi-domain]  Cd Length: 206  Bit Score: 35.20  E-value: 9.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195582801  12 ILITGTPGAGKSYLCERIASELKFE----------WLDCSKIAKEnnfvEEYDEEYDCP-ILDEEKLMDHLEPLMAkgGN 80
Cdd:COG0572   10 IGIAGPSGSGKTTFARRLAEQLGADkvvvislddyYKDREHLPLD----ERGKPNFDHPeAFDLDLLNEHLEPLKA--GE 83


                 ....
gi 195582801  81 VVEY 84
Cdd:COG0572   84 SVEL 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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