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Conserved domains on  [gi|195342423|ref|XP_002037800|]
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protein arginine N-methyltransferase 8 [Drosophila sechellia]

Protein Classification

SAM-dependent methyltransferase( domain architecture ID 1905023)

SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168
PubMed:  12826405|12504684
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4076 super family cl44002
Predicted RNA methylase [General function prediction only];
39-204 2.58e-31

Predicted RNA methylase [General function prediction only];


The actual alignment was detected with superfamily member COG4076:

Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 118.22  E-value: 2.58e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195342423  39 RIEIHEWLLKDSVRIKAYREAIQHNeFFKHKTVLDVGCGMGVLSIFAAKAGSKRVLAVDA-ATISEYAQQVAQDNEFGRV 117
Cdd:COG4076    8 VPRWHHPMLNDVERNDAFKAAIERV-VKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVnPDIAAVARRIIAANGLSDR 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195342423 118 ITVIQGKVEDIELPNgikKVDIIVCDWMGSSLFSGNMLESLLFARDKWLSSAGHIYPDTAQLYLAAIKGrDQDLGFWHD- 196
Cdd:COG4076   87 ITVINADATDLDLPE---KADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVES-PVDAEGFEDw 162


                 ....*....
gi 195342423 197 -VHGFDLSA 204
Cdd:COG4076  163 qFDGFDFRL 171
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
39-204 2.58e-31

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 118.22  E-value: 2.58e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195342423  39 RIEIHEWLLKDSVRIKAYREAIQHNeFFKHKTVLDVGCGMGVLSIFAAKAGSKRVLAVDA-ATISEYAQQVAQDNEFGRV 117
Cdd:COG4076    8 VPRWHHPMLNDVERNDAFKAAIERV-VKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVnPDIAAVARRIIAANGLSDR 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195342423 118 ITVIQGKVEDIELPNgikKVDIIVCDWMGSSLFSGNMLESLLFARDKWLSSAGHIYPDTAQLYLAAIKGrDQDLGFWHD- 196
Cdd:COG4076   87 ITVINADATDLDLPE---KADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVES-PVDAEGFEDw 162


                 ....*....
gi 195342423 197 -VHGFDLSA 204
Cdd:COG4076  163 qFDGFDFRL 171
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
66-142 5.53e-13

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 67.87  E-value: 5.53e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 195342423  66 FKHKTVLDVGCGMGVLSIFAAKAGSKRVLAVDaatISEYAQQVAQDN-EFGRVItviqgkvEDIELPNGIKKVDIIVC 142
Cdd:PRK00517 118 LPGKTVLDVGCGSGILAIAAAKLGAKKVLAVD---IDPQAVEAARENaELNGVE-------LNVYLPQGDLKADVIVA 185
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 71-142 2.64e-12

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 62.20  E-value: 2.64e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 195342423   71 VLDVGCGMGVLSIFAAKAGSKRVLAVDaatISEYAQQVAQDN--EFGRVITVIQGKVEDIELPNGikKVDIIVC 142
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVD---LSPEMLERARERaaEAGLNVEFVQGDAEDLPFPDG--SFDLVVS 69
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 70-150 1.49e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 57.83  E-value: 1.49e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195342423  70 TVLDVGCGMGVLSIFAAKAGSKRVLAVDaatISEYAQQVAQDNEFGRV---ITVIQGKVEDIeLPNGIKKVDIIVCDWMG 146
Cdd:cd02440    1 RVLDLGCGTGALALALASGPGARVTGVD---ISPVALELARKAAAALLadnVEVLKGDAEEL-PPEADESFDVIISDPPL 76


                 ....
gi 195342423 147 SSLF 150
Cdd:cd02440   77 HHLV 80
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
39-204 2.58e-31

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 118.22  E-value: 2.58e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195342423  39 RIEIHEWLLKDSVRIKAYREAIQHNeFFKHKTVLDVGCGMGVLSIFAAKAGSKRVLAVDA-ATISEYAQQVAQDNEFGRV 117
Cdd:COG4076    8 VPRWHHPMLNDVERNDAFKAAIERV-VKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVnPDIAAVARRIIAANGLSDR 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195342423 118 ITVIQGKVEDIELPNgikKVDIIVCDWMGSSLFSGNMLESLLFARDKWLSSAGHIYPDTAQLYLAAIKGrDQDLGFWHD- 196
Cdd:COG4076   87 ITVINADATDLDLPE---KADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERITNAAQPVES-PVDAEGFEDw 162


                 ....*....
gi 195342423 197 -VHGFDLSA 204
Cdd:COG4076  163 qFDGFDFRL 171
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
66-142 5.53e-13

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 67.87  E-value: 5.53e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 195342423  66 FKHKTVLDVGCGMGVLSIFAAKAGSKRVLAVDaatISEYAQQVAQDN-EFGRVItviqgkvEDIELPNGIKKVDIIVC 142
Cdd:PRK00517 118 LPGKTVLDVGCGSGILAIAAAKLGAKKVLAVD---IDPQAVEAARENaELNGVE-------LNVYLPQGDLKADVIVA 185
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 71-142 2.64e-12

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 62.20  E-value: 2.64e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 195342423   71 VLDVGCGMGVLSIFAAKAGSKRVLAVDaatISEYAQQVAQDN--EFGRVITVIQGKVEDIELPNGikKVDIIVC 142
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVD---LSPEMLERARERaaEAGLNVEFVQGDAEDLPFPDG--SFDLVVS 69
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
66-142 2.75e-12

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 66.35  E-value: 2.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195342423  66 FKHKTVLDVGCGMGVLSIFAAKAGSKRVLAVDaatISEYAQQVAQD----NEFGRVITVIQGKVEDIElpngikKVDIIV 141
Cdd:COG2264  147 KPGKTVLDVGCGSGILAIAAAKLGAKRVLAVD---IDPVAVEAAREnaelNGVEDRIEVVLGDLLEDG------PYDLVV 217


                 .
gi 195342423 142 C 142
Cdd:COG2264  218 A 218
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 67-142 5.65e-12

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 62.34  E-value: 5.65e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 195342423  67 KHKTVLDVGCGMGVLSIFAAKAGsKRVLAVDaatISEYAQQVAQDNEFGRVITVIQGKVEDIELPNGikKVDIIVC 142
Cdd:COG2227   24 AGGRVLDVGCGTGRLALALARRG-ADVTGVD---ISPEALEIARERAAELNVDFVQGDLEDLPLEDG--SFDLVIC 93
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 70-150 1.49e-10

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 57.83  E-value: 1.49e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195342423  70 TVLDVGCGMGVLSIFAAKAGSKRVLAVDaatISEYAQQVAQDNEFGRV---ITVIQGKVEDIeLPNGIKKVDIIVCDWMG 146
Cdd:cd02440    1 RVLDLGCGTGALALALASGPGARVTGVD---ISPVALELARKAAAALLadnVEVLKGDAEEL-PPEADESFDVIISDPPL 76


                 ....
gi 195342423 147 SSLF 150
Cdd:cd02440   77 HHLV 80
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 69-142 1.75e-10

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 61.13  E-value: 1.75e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 195342423   69 KTVLDVGCGMGVLSIFAAKAGSKRVLAVDaatISEYAQQVAQDN-EFGRVITVIQGKVEDiELPNGikKVDIIVC 142
Cdd:pfam06325 163 ESVLDVGCGSGILAIAALKLGAKKVVGVD---IDPVAVRAAKENaELNGVEARLEVYLPG-DLPKE--KADVVVA 231
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
69-141 1.86e-10

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 59.53  E-value: 1.86e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 195342423  69 KTVLDVGCGMGVLSIFAAKAGSKRVLAVDaatISEYAQQVAQDNeFGRVITVIQGKVEDIELPNGIKKVDIIV 141
Cdd:COG2263   47 KTVLDLGCGTGMLAIGAALLGAKKVVGVD---IDPEALEIAREN-AERLGVRVDFIRADVTRIPLGGSVDTVV 115
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 55-142 2.76e-09

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 55.00  E-value: 2.76e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195342423  55 AYREAIQHNEFFKHKTVLDVGCGMGVLSIFAAKAGSkRVLAVDaatISEYAQQVAQDN--EFGRVITVIQGKVEDIELPN 132
Cdd:COG2226   10 GREALLAALGLRPGARVLDLGCGTGRLALALAERGA-RVTGVD---ISPEMLELARERaaEAGLNVEFVVGDAEDLPFPD 85

                         90
                 ....*....|
gi 195342423 133 GikKVDIIVC 142
Cdd:COG2226   86 G--SFDLVIS 93
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 58-142 1.02e-08

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 54.89  E-value: 1.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195342423  58 EAIQHNEFFKHKTVLDVGCGMGVLSIFAAKAGSKRVLAVDAATISEYAQQV-AQDNEFGrvITVIQGkveDIELPNGIKK 136
Cdd:COG3897   61 RYLLDHPEVAGKRVLELGCGLGLVGIAAAKAGAADVTATDYDPEALAALRLnAALNGVA--ITTRLG---DWRDPPAAGG 135


                 ....*.
gi 195342423 137 VDIIVC 142
Cdd:COG3897  136 FDLILG 141
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 67-143 3.76e-08

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 52.03  E-value: 3.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195342423   67 KHKTVLDVGCGMGVLSIFAAK--AGSKRVLAVDaatISE----YAQQVAQDNEFGRViTVIQGKVEDIELPNGIKKVDII 140
Cdd:pfam13847   3 KGMRVLDLGCGTGHLSFELAEelGPNAEVVGID---ISEeaieKARENAQKLGFDNV-EFEQGDIEELPELLEDDKFDVV 78


                  ...
gi 195342423  141 VCD 143
Cdd:pfam13847  79 ISN 81
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 70-142 4.09e-08

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 51.85  E-value: 4.09e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 195342423  70 TVLDVGCGMGVLSIFAAKAGSKRVLAVdaaTIS----EYAQQVAQDNEFGRVITVIQGKVEDIELPNgikKVDIIVC 142
Cdd:COG2230   54 RVLDIGCGWGGLALYLARRYGVRVTGV---TLSpeqlEYARERAAEAGLADRVEVRLADYRDLPADG---QFDAIVS 124
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 72-142 3.87e-07

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 47.66  E-value: 3.87e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 195342423   72 LDVGCGMGVLSIFAAKAGSkRVLAVDaatISEYAQQVAQDNEFGRVITVIQGKVEDIELPNGikKVDIIVC 142
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGA-RVTGVD---ISPEMLELAREKAPREGLTFVVGDAEDLPFPDN--SFDLVLS 65
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 39-143 1.04e-06

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 50.18  E-value: 1.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195342423  39 RIEIHEWLLKDSVRIKAY------------REAIQhnEFFKHKTVLDVGCGMGVLSIFAAKAGSKRVLAVDaatISEYAQ 106
Cdd:COG1092  178 EVEVEENGLKFLVDLTDGqktglfldqrenRARVA--ELAKGKRVLNLFSYTGGFSVHAAAGGAKSVTSVD---LSATAL 252

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 195342423 107 QVAQD----NEFGRVITVIQGKVEDI--ELPNGIKKVDIIVCD 143
Cdd:COG1092  253 EWAKEnaalNGLDDRHEFVQADAFDWlrELAREGERFDLIILD 295
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 69-142 1.41e-06

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 48.60  E-value: 1.41e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 195342423  69 KTVLDVGCGMGVLSIF-AAKAGSKRVLAVD----AAtisEYAQQVAQDNEFGRVITVIQGKVEDIELPNGIKKVDIIVC 142
Cdd:COG4123   39 GRVLDLGTGTGVIALMlAQRSPGARITGVEiqpeAA---ELARRNVALNGLEDRITVIHGDLKEFAAELPPGSFDLVVS 114
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 57-142 3.99e-06

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 47.84  E-value: 3.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195342423  57 REAIQHNEFFKHKTVLDVGCGMGVLSIFAAKAGSK-RVLAVDaatISEYAQQVAQDN----EFGRVITVIQGkveDI--E 129
Cdd:COG2890  102 ELALALLPAGAPPRVLDLGTGSGAIALALAKERPDaRVTAVD---ISPDALAVARRNaerlGLEDRVRFLQG---DLfeP 175

                         90
                 ....*....|...
gi 195342423 130 LPnGIKKVDIIVC 142
Cdd:COG2890  176 LP-GDGRFDLIVS 187
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 67-142 6.03e-06

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 46.45  E-value: 6.03e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 195342423  67 KHKTVLDVGCGMGVLSIFAAKAGSKRVLAVDAATIS-EYAQQVAQDNEFGRViTVIQGKVEDIElPNGIKKVDIIVC 142
Cdd:COG0500   26 KGGRVLDLGCGTGRNLLALAARFGGRVIGIDLSPEAiALARARAAKAGLGNV-EFLVADLAELD-PLPAESFDLVVA 100
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
56-142 7.13e-06

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 45.76  E-value: 7.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195342423  56 YREAIQHNEFFKHKTVLDVGCGMGVLSIFAAKAGsKRVLAVDaatISEYAQQVAQDNefGRVITVIQGKVEDIELPNGik 135
Cdd:COG4976   35 AEELLARLPPGPFGRVLDLGCGTGLLGEALRPRG-YRLTGVD---LSEEMLAKAREK--GVYDRLLVADLADLAEPDG-- 106


                 ....*..
gi 195342423 136 KVDIIVC 142
Cdd:COG4976  107 RFDLIVA 113
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 70-142 8.30e-06

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 45.95  E-value: 8.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195342423  70 TVLDVGCGMGVLSIFAAKAGSK-RVLAVDaatIS----EYAQQVAQDNEFGRViTVIQG----KVEDielpngiKKVDII 140
Cdd:COG2813   52 RVLDLGCGYGVIGLALAKRNPEaRVTLVD---VNaravELARANAAANGLENV-EVLWSdglsGVPD-------GSFDLI 120


                 ..
gi 195342423 141 VC 142
Cdd:COG2813  121 LS 122
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 56-143 9.59e-06

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 47.09  E-value: 9.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195342423  56 YREAIQHNEFFKHKTVLDVGCGMGVLSIFAAKAGsKRVLAV--DAATIsEYAQQVAQDNEFGRViTVIQGKVEDI--ELP 131
Cdd:COG2265  222 YAAALEWLDLTGGERVLDLYCGVGTFALPLARRA-KKVIGVeiVPEAV-EDARENARLNGLKNV-EFVAGDLEEVlpELL 298

                         90
                 ....*....|..
gi 195342423 132 NGIkKVDIIVCD 143
Cdd:COG2265  299 WGG-RPDVVVLD 309
PRK14967 PRK14967
putative methyltransferase; Provisional
 68-123 1.37e-05

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 45.81  E-value: 1.37e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 195342423  68 HKTVLDVGCGMGVLSIFAAKAGSKRVLAVDaatISEYAQQVAQDNEF--GRVITVIQG 123
Cdd:PRK14967  37 GRRVLDLCTGSGALAVAAAAAGAGSVTAVD---ISRRAVRSARLNALlaGVDVDVRRG 91
PRK14968 PRK14968
putative methyltransferase; Provisional
 67-112 1.80e-05

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 44.89  E-value: 1.80e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 195342423  67 KHKTVLDVGCGMGVLSIFAAKAGsKRVLAVDaatISEYAQQVAQDN 112
Cdd:PRK14968  23 KGDRVLEVGTGSGIVAIVAAKNG-KKVVGVD---INPYAVECAKCN 64
FtsJ pfam01728
FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal ...
 58-143 3.28e-05

FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. This family also includes the N terminus of flaviviral NS5 protein. It has been hypothesized that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping.


Pssm-ID: 426399  Cd Length: 179  Bit Score: 44.12  E-value: 3.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195342423   58 EAIQHNEFFKH-KTVLDVGCGMGVLSIFAAKAGSKRVLAVDAATIseyaqQVAQDNEFGRViTVIQG-----KVEDIELP 131
Cdd:pfam01728  11 EIDEKFGLLKPgKTVLDLGAAPGGWSQVALQRGAGKVVGVDLGPM-----QLWKPRNDPGV-TFIQGdirdpETLDLLEE 84

                          90
                  ....*....|..
gi 195342423  132 NGIKKVDIIVCD 143
Cdd:pfam01728  85 LLGRKVDLVLSD 96
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
70-142 8.98e-05

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 40.96  E-value: 8.98e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 195342423  70 TVLDVGCGMGVLS-IFAAKAGSKRVLAVDaatISEYAQQVAQDNeFGRViTVIQGKVEDIELPngiKKVDIIVC 142
Cdd:COG4106    4 RVLDLGCGTGRLTaLLAERFPGARVTGVD---LSPEMLARARAR-LPNV-RFVVADLRDLDPP---EPFDLVVS 69
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 69-142 1.84e-04

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 41.42  E-value: 1.84e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 195342423   69 KTVLDVGCGMGVLSIFAAKAGSKrvLAVDAATISEYA----QQVAQDNEFgRVITVIQGKV-EDIELpngiKKVDIIVC 142
Cdd:pfam05175  33 GKVLDLGCGAGVLGAALAKESPD--AELTMVDINARAlesaRENLAANGL-ENGEVVASDVySGVED----GKFDLIIS 104
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 57-132 1.95e-04

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 42.45  E-value: 1.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195342423  57 REAIQHNEFFKHKTVLDVGCGMGVLSIFAAKAGSK--RVLAVDaatISE----YAQQVAQDNEFGRVITVIQGKVEDIEL 130
Cdd:PRK00216  41 RKTIKWLGVRPGDKVLDLACGTGDLAIALAKAVGKtgEVVGLD---FSEgmlaVGREKLRDLGLSGNVEFVQGDAEALPF 117


                 ..
gi 195342423 131 PN 132
Cdd:PRK00216 118 PD 119
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 58-142 6.54e-04

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 40.92  E-value: 6.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 195342423  58 EAIQHNEFFKHKTVLDVGCGMGVLSIFAAKA-GSKRVLAVDaatISEYAQQVAQDN---EFGRVITVIQGKVEDiELPNG 133
Cdd:PRK09328  99 WALEALLLKEPLRVLDLGTGSGAIALALAKErPDAEVTAVD---ISPEALAVARRNakhGLGARVEFLQGDWFE-PLPGG 174


                 ....*....
gi 195342423 134 ikKVDIIVC 142
Cdd:PRK09328 175 --RFDLIVS 181
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 69-111 6.57e-04

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 40.59  E-value: 6.57e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 195342423  69 KTVLDVGCGMGVLSIFAAKAGSkRVLAVD-AATISEYAQQVAQD 111
Cdd:PRK07580  65 LRILDAGCGVGSLSIPLARRGA-KVVASDiSPQMVEEARERAPE 107
Dcm COG0270
DNA-cytosine methylase [Replication, recombination and repair];
67-141 1.86e-03

DNA-cytosine methylase [Replication, recombination and repair];


Pssm-ID: 440040 [Multi-domain]  Cd Length: 277  Bit Score: 39.41  E-value: 1.86e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 195342423  67 KHKTVLDVGCGMGVLSIFAAKAGSKRVLAVDaatISEYAQQVAQDNeFGRViTVIQGKVEDIELPNGIKKVDIIV 141
Cdd:COG0270    2 KKLTVIDLFAGAGGLSLGFEKAGFEVVFAVE---IDPDACETYRAN-FPEA-KVIEGDIRDIDPEELIPDVDLLI 71
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
70-132 4.79e-03

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 38.34  E-value: 4.79e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 195342423  70 TVLDVGCGMGVLSIFAAKAGsKRVLAVDA-ATISEYAQQVAqdNEFGRViTVIQGKVEDIELPN 132
Cdd:PRK14896  32 PVLEIGPGKGALTDELAKRA-KKVYAIELdPRLAEFLRDDE--IAAGNV-EIIEGDALKVDLPE 91
CMAS pfam02353
Mycolic acid cyclopropane synthetase; This family consist of ...
 70-141 8.23e-03

Mycolic acid cyclopropane synthetase; This family consist of Cyclopropane-fatty-acyl-phospholipid synthase or CFA synthase EC:2.1.1.79 this enzyme catalyze the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid <=> S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid.


Pssm-ID: 396777 [Multi-domain]  Cd Length: 272  Bit Score: 37.69  E-value: 8.23e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 195342423   70 TVLDVGCGMGVLSIFAAKAGSKRVLAVdaaTIS----EYAQQVAQDNEFGRVITVIQGKVEDIElpngiKKVDIIV 141
Cdd:pfam02353  64 TLLDIGCGWGGLMRRAAERYDVNVVGL---TLSknqyKLARKRVAAEGLARKVEVLLQDYRDFD-----EPFDRIV 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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