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Conserved domains on  [gi|1949665175|ref|XP_038177273|]
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GPI mannosyltransferase 3 isoform X2 [Arvicola amphibius]

Protein Classification

glycosyltransferase family protein( domain architecture ID 229536)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PMT_2 super family cl21590
Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are ...
 22-501 4.68e-96

Dolichyl-phosphate-mannose-protein mannosyltransferase; This family contains members that are not captured by pfam02366.


The actual alignment was detected with superfamily member PLN02816:

Pssm-ID: 473917  Cd Length: 546  Bit Score: 301.95  E-value: 4.68e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949665175  22 MKLRKRKST----------LYVNTQEKRSQRGGLLGESTYLVLFTIALRILNCFLVQTSFVPDEYWQSLEVAHHMVFSYG 91
Cdd:PLN02816    1 MDIRKRKNAggdgdggadgASVNVGDEPDSFGGRIGSPRRIFLFCLAFRVVNALLIQTYFNPDEHWQSLEVAHRTIFGYG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949665175  92 YLTWEWTERLRGYTYPLIFASIYKILHLLGKDSVQLLIWIPRLGQALLSAVADVRLYSLMKHVGNQEVARWVFFCQLCSW 171
Cdd:PLN02816   81 YMTWEWKRGIRSYLHPMLFAFLYKLLQVTGLDTPYIMIKAPRLMQSIFSAIGDLYLYKLSDALYGGNVATWSLFCQMANW 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949665175 172 FTWYCCTRTLTNTTETALTAIALFYYPLEGSRSMN---SVKYSLLV-ALACIVRPTALIPWVPLLFSHFHQEQRKRHLTL 247
Cdd:PLN02816  161 FIFFCLNRTFSNCLETVLTIMGLYYWPCIRDSSIDypvNRKWGLVIaALACAIRPTSAVIWLYVGMLELFLTPNKVKFII 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949665175 248 YRFLPVGIITFSLSLIIDRIFFGQNL---------------GTFYGSHPWHWYFSQGFPVVLGTHLPFFIHGCFLAPRRL 312
Cdd:PLN02816  241 LEVIPIGSLVLGFTCLLDRLMYGSWVivplnflkfnflssgGDYYGTHPWHWYFTQGFLVMLFTFTPFSIAGIIKSKNQK 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949665175 313 hiLLLTMLWTLLVYSMLGHKEFRFIYPVLPFCMVFCGYSLAHLKA----------------------WR---KVALSFLL 367
Cdd:PLN02816  321 --LSALILWVLAIYSILGHKEFRFVLPVLPIALIFSGYAFAQMEVsgssssssvtkkkqvprqnhtkWSpklRLSVYFLL 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949665175 368 LSNTLLALYTGLVHQRGTLDVMSHIQQVCPRGpdpASVSVFIMMPCHSTPYYSHVHCPLSMRFLQCPPdlTGKPQYLDEA 447
Cdd:PLN02816  399 ATNIPMALYMSLFHQRGTEDAMNYLSDEAYKG---RVKSILFLMPCHSTPYYSTLHRNIPMQFLDCTP--SAEKGELDES 473

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1949665175 448 DAFYLNPLSWLQQEFRSNASLPTHLVSFSVLEKEIRAFLTSGSYERTAIVFHTH 501
Cdd:PLN02816  474 DQFLVNPLGFASELARNWSEPPSHIVLFASEETKLRDFMIQHSFKEVRRFFHAH 527
 
Name Accession Description Interval E-value
PLN02816 PLN02816
mannosyltransferase
 22-501 4.68e-96

mannosyltransferase


Pssm-ID: 215437  Cd Length: 546  Bit Score: 301.95  E-value: 4.68e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949665175  22 MKLRKRKST----------LYVNTQEKRSQRGGLLGESTYLVLFTIALRILNCFLVQTSFVPDEYWQSLEVAHHMVFSYG 91
Cdd:PLN02816    1 MDIRKRKNAggdgdggadgASVNVGDEPDSFGGRIGSPRRIFLFCLAFRVVNALLIQTYFNPDEHWQSLEVAHRTIFGYG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949665175  92 YLTWEWTERLRGYTYPLIFASIYKILHLLGKDSVQLLIWIPRLGQALLSAVADVRLYSLMKHVGNQEVARWVFFCQLCSW 171
Cdd:PLN02816   81 YMTWEWKRGIRSYLHPMLFAFLYKLLQVTGLDTPYIMIKAPRLMQSIFSAIGDLYLYKLSDALYGGNVATWSLFCQMANW 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949665175 172 FTWYCCTRTLTNTTETALTAIALFYYPLEGSRSMN---SVKYSLLV-ALACIVRPTALIPWVPLLFSHFHQEQRKRHLTL 247
Cdd:PLN02816  161 FIFFCLNRTFSNCLETVLTIMGLYYWPCIRDSSIDypvNRKWGLVIaALACAIRPTSAVIWLYVGMLELFLTPNKVKFII 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949665175 248 YRFLPVGIITFSLSLIIDRIFFGQNL---------------GTFYGSHPWHWYFSQGFPVVLGTHLPFFIHGCFLAPRRL 312
Cdd:PLN02816  241 LEVIPIGSLVLGFTCLLDRLMYGSWVivplnflkfnflssgGDYYGTHPWHWYFTQGFLVMLFTFTPFSIAGIIKSKNQK 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949665175 313 hiLLLTMLWTLLVYSMLGHKEFRFIYPVLPFCMVFCGYSLAHLKA----------------------WR---KVALSFLL 367
Cdd:PLN02816  321 --LSALILWVLAIYSILGHKEFRFVLPVLPIALIFSGYAFAQMEVsgssssssvtkkkqvprqnhtkWSpklRLSVYFLL 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949665175 368 LSNTLLALYTGLVHQRGTLDVMSHIQQVCPRGpdpASVSVFIMMPCHSTPYYSHVHCPLSMRFLQCPPdlTGKPQYLDEA 447
Cdd:PLN02816  399 ATNIPMALYMSLFHQRGTEDAMNYLSDEAYKG---RVKSILFLMPCHSTPYYSTLHRNIPMQFLDCTP--SAEKGELDES 473

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1949665175 448 DAFYLNPLSWLQQEFRSNASLPTHLVSFSVLEKEIRAFLTSGSYERTAIVFHTH 501
Cdd:PLN02816  474 DQFLVNPLGFASELARNWSEPPSHIVLFASEETKLRDFMIQHSFKEVRRFFHAH 527
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
 51-423 1.26e-93

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 291.58  E-value: 1.26e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949665175  51 YLVLFTIALRILNCFLVQTSfVPDEYWQSLEVAHHMVFSYGYLTWEWTER--LRGYTYPLIFASIYKILHLLGKDSVQLL 128
Cdd:pfam03901   1 WIFLLLLALRLLLALLVQTS-DPDEHFQSWEPLHYLIFGYGFLTWEWSPKygIRSYLYPLLFALPYYLLARLFGDSKYLV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949665175 129 IWIPRLGQALLSAVADVRLYSLMKHVGNQEVARWVFFCQLCSWFTWYCCTRTLTNTTETALTAIALFYYPLEGSRSM--- 205
Cdd:pfam03901  80 FYAPRLLLGLFSALCDYYLYRAVCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLLEYGNTSVsny 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949665175 206 -NSVKYSLLVALACIVRPTALIPWVPLLFSHFHQE-QRKRHLTLYRFLPVGIITFSL----SLIIDRIFFGQ-------- 271
Cdd:pfam03901 160 kYLKAVLLIAALAILGRPTSALLWLPLVLYLLLRLrGKRLKLFLFLAISLGLLVALLvlgaVILIDSYFYGRfvftplnf 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949665175 272 -------NLGTFYGSHPWHWYFSQGFPVVLGTHLPFFIHGCFLAPR----RLHILLLTMLWTLLVYSMLGHKEFRFIYPV 340
Cdd:pfam03901 240 lkynvlsNGSSFYGTHPWYFYFSNGLPNILGPFLLAFILGPLVLLLrkvsRLSQLLAPILIWLFIYSLQPHKEERFLYPV 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949665175 341 LPFCMVFCGYSLAHLKAWRKVA------LSFLLLSNTLLALYTGLVHQRGTL----DVMSHIQQVCPRGPDPA--SVSVF 408
Cdd:pfam03901 320 YPLILLSAAIALTRLSRRSWKVrkklslLFLLLFFNVSLARLFGLVHQYGAPlavyDVMSFLNETPRENRNPAgpPVNVC 399

                         410
                  ....*....|....*
gi 1949665175 409 IMMPCHSTPYYSHVH 423
Cdd:pfam03901 400 IGMECYSTPSSFFLH 414
 
Name Accession Description Interval E-value
PLN02816 PLN02816
mannosyltransferase
 22-501 4.68e-96

mannosyltransferase


Pssm-ID: 215437  Cd Length: 546  Bit Score: 301.95  E-value: 4.68e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949665175  22 MKLRKRKST----------LYVNTQEKRSQRGGLLGESTYLVLFTIALRILNCFLVQTSFVPDEYWQSLEVAHHMVFSYG 91
Cdd:PLN02816    1 MDIRKRKNAggdgdggadgASVNVGDEPDSFGGRIGSPRRIFLFCLAFRVVNALLIQTYFNPDEHWQSLEVAHRTIFGYG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949665175  92 YLTWEWTERLRGYTYPLIFASIYKILHLLGKDSVQLLIWIPRLGQALLSAVADVRLYSLMKHVGNQEVARWVFFCQLCSW 171
Cdd:PLN02816   81 YMTWEWKRGIRSYLHPMLFAFLYKLLQVTGLDTPYIMIKAPRLMQSIFSAIGDLYLYKLSDALYGGNVATWSLFCQMANW 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949665175 172 FTWYCCTRTLTNTTETALTAIALFYYPLEGSRSMN---SVKYSLLV-ALACIVRPTALIPWVPLLFSHFHQEQRKRHLTL 247
Cdd:PLN02816  161 FIFFCLNRTFSNCLETVLTIMGLYYWPCIRDSSIDypvNRKWGLVIaALACAIRPTSAVIWLYVGMLELFLTPNKVKFII 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949665175 248 YRFLPVGIITFSLSLIIDRIFFGQNL---------------GTFYGSHPWHWYFSQGFPVVLGTHLPFFIHGCFLAPRRL 312
Cdd:PLN02816  241 LEVIPIGSLVLGFTCLLDRLMYGSWVivplnflkfnflssgGDYYGTHPWHWYFTQGFLVMLFTFTPFSIAGIIKSKNQK 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949665175 313 hiLLLTMLWTLLVYSMLGHKEFRFIYPVLPFCMVFCGYSLAHLKA----------------------WR---KVALSFLL 367
Cdd:PLN02816  321 --LSALILWVLAIYSILGHKEFRFVLPVLPIALIFSGYAFAQMEVsgssssssvtkkkqvprqnhtkWSpklRLSVYFLL 398

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949665175 368 LSNTLLALYTGLVHQRGTLDVMSHIQQVCPRGpdpASVSVFIMMPCHSTPYYSHVHCPLSMRFLQCPPdlTGKPQYLDEA 447
Cdd:PLN02816  399 ATNIPMALYMSLFHQRGTEDAMNYLSDEAYKG---RVKSILFLMPCHSTPYYSTLHRNIPMQFLDCTP--SAEKGELDES 473

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1949665175 448 DAFYLNPLSWLQQEFRSNASLPTHLVSFSVLEKEIRAFLTSGSYERTAIVFHTH 501
Cdd:PLN02816  474 DQFLVNPLGFASELARNWSEPPSHIVLFASEETKLRDFMIQHSFKEVRRFFHAH 527
Glyco_transf_22 pfam03901
Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. ...
 51-423 1.26e-93

Alg9-like mannosyltransferase family; Members of this family are mannosyltransferase enzymes. At least some members are localized in endoplasmic reticulum and involved in GPI anchor biosynthesis.


Pssm-ID: 281842  Cd Length: 414  Bit Score: 291.58  E-value: 1.26e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949665175  51 YLVLFTIALRILNCFLVQTSfVPDEYWQSLEVAHHMVFSYGYLTWEWTER--LRGYTYPLIFASIYKILHLLGKDSVQLL 128
Cdd:pfam03901   1 WIFLLLLALRLLLALLVQTS-DPDEHFQSWEPLHYLIFGYGFLTWEWSPKygIRSYLYPLLFALPYYLLARLFGDSKYLV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949665175 129 IWIPRLGQALLSAVADVRLYSLMKHVGNQEVARWVFFCQLCSWFTWYCCTRTLTNTTETALTAIALFYYPLEGSRSM--- 205
Cdd:pfam03901  80 FYAPRLLLGLFSALCDYYLYRAVCRKYGLEIARWALLLSLTSWGMFFASTRTLPNSFEMILTSIALYYLLEYGNTSVsny 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949665175 206 -NSVKYSLLVALACIVRPTALIPWVPLLFSHFHQE-QRKRHLTLYRFLPVGIITFSL----SLIIDRIFFGQ-------- 271
Cdd:pfam03901 160 kYLKAVLLIAALAILGRPTSALLWLPLVLYLLLRLrGKRLKLFLFLAISLGLLVALLvlgaVILIDSYFYGRfvftplnf 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949665175 272 -------NLGTFYGSHPWHWYFSQGFPVVLGTHLPFFIHGCFLAPR----RLHILLLTMLWTLLVYSMLGHKEFRFIYPV 340
Cdd:pfam03901 240 lkynvlsNGSSFYGTHPWYFYFSNGLPNILGPFLLAFILGPLVLLLrkvsRLSQLLAPILIWLFIYSLQPHKEERFLYPV 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1949665175 341 LPFCMVFCGYSLAHLKAWRKVA------LSFLLLSNTLLALYTGLVHQRGTL----DVMSHIQQVCPRGPDPA--SVSVF 408
Cdd:pfam03901 320 YPLILLSAAIALTRLSRRSWKVrkklslLFLLLFFNVSLARLFGLVHQYGAPlavyDVMSFLNETPRENRNPAgpPVNVC 399

                         410
                  ....*....|....*
gi 1949665175 409 IMMPCHSTPYYSHVH 423
Cdd:pfam03901 400 IGMECYSTPSSFFLH 414
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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