NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|194713878|gb|ACF93099|]
View 

formate hydrogenlyase, subunit F [Salmonella enterica subsp. enterica serovar Schwarzengrund str. CVM19633]

Protein Classification

formate hydrogenlyase complex iron-sulfur subunit( domain architecture ID 11485882)

formate hydrogenlyase complex iron-sulfur subunit is a 4Fe-4S dicluster domain-containing protein that may function as an electron transfer protein for the hydrogenase

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK12387 PRK12387
formate hydrogenlyase complex iron-sulfur subunit; Provisional
 1-180 5.74e-122

formate hydrogenlyase complex iron-sulfur subunit; Provisional


:

Pssm-ID: 183492 [Multi-domain]  Cd Length: 180  Bit Score: 341.24  E-value: 5.74e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194713878   1 MFTFIKKVIKTGTATSSYPLEPIAVDKNFRGKPEHNPQQCIGCAACVNACPSNALTVETDLATNELAWQFNLSRCIFCGR 80
Cdd:PRK12387   1 MFKLIKKVIKTGTATSSYPLEPIAVDKNFRGKPEYNPQQCIGCAACVNACPSNALTVETDLATGELAWEFNLGRCIFCGR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194713878  81 CEEVCPTAAIKLSQEYELAVWKKEDFLQQSRFALCNCRVCNRPFAVQKEIDYAIALLAHNGDSRAENHRESFETCPDCKR 160
Cdd:PRK12387  81 CEEVCPTAAIKLSQEFELAVWKKEDLLQQSEFALCNCRVCGRPFAVQKEIDYAIALLKHNGDSRAENHRESFETCPECKR 160

                        170       180
                 ....*....|....*....|
gi 194713878 161 QKCLVPSDRIELTRHMKEVS 180
Cdd:PRK12387 161 QKCLVPSDRIELTRHMKEAI 180
 
Name Accession Description Interval E-value
PRK12387 PRK12387
formate hydrogenlyase complex iron-sulfur subunit; Provisional
 1-180 5.74e-122

formate hydrogenlyase complex iron-sulfur subunit; Provisional


Pssm-ID: 183492 [Multi-domain]  Cd Length: 180  Bit Score: 341.24  E-value: 5.74e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194713878   1 MFTFIKKVIKTGTATSSYPLEPIAVDKNFRGKPEHNPQQCIGCAACVNACPSNALTVETDLATNELAWQFNLSRCIFCGR 80
Cdd:PRK12387   1 MFKLIKKVIKTGTATSSYPLEPIAVDKNFRGKPEYNPQQCIGCAACVNACPSNALTVETDLATGELAWEFNLGRCIFCGR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194713878  81 CEEVCPTAAIKLSQEYELAVWKKEDFLQQSRFALCNCRVCNRPFAVQKEIDYAIALLAHNGDSRAENHRESFETCPDCKR 160
Cdd:PRK12387  81 CEEVCPTAAIKLSQEFELAVWKKEDLLQQSEFALCNCRVCGRPFAVQKEIDYAIALLKHNGDSRAENHRESFETCPECKR 160

                        170       180
                 ....*....|....*....|
gi 194713878 161 QKCLVPSDRIELTRHMKEVS 180
Cdd:PRK12387 161 QKCLVPSDRIELTRHMKEAI 180
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 33-173 1.24e-21

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 85.14  E-value: 1.24e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194713878  33 PEHNPQQCIGCAACVNACPSNALTVETDLATNELaWQFNLSRCIFCGRCEEVCPTAAIKLSQEY-ELAVWKKEDFLQQSR 111
Cdd:cd10549    1 LKYDPEKCIGCGICVKACPTDAIELGPNGAIARG-PEIDEDKCVFCGACVEVCPTGAIELTPEGkEYVPKEKEAEIDEEK 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 194713878 112 faLCNCRVCNRPFAVQkeidyAIALlahngdSRAENHRESFETCPDCKR--QKClvPSDRIELT 173
Cdd:cd10549   80 --CIGCGLCVKVCPVD-----AITL------EDELEIVIDKEKCIGCGIcaEVC--PVNAIKLV 128
NuoI TIGR01971
NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of ...
 15-106 1.01e-20

NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This model excludes "I" subunits from the closely related F420H2 dehydrogenase and formate hydrogenlyase complexes. [Energy metabolism, Electron transport]


Pssm-ID: 273902 [Multi-domain]  Cd Length: 122  Bit Score: 82.46  E-value: 1.01e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194713878   15 TSSYPLEPIAVDKNFRG-----KPEHNPQQCIGCAACVNACPSNALTVET----DLATNELAWQFNLSRCIFCGRCEEVC 85
Cdd:TIGR01971  15 TVQYPEEKLYLPPRFRGrivltRDPNGEEKCIGCTLCAAVCPADAIRVVPaegeDGKRRLKFYEINFGRCIFCGLCEEAC 94

                          90       100
                  ....*....|....*....|.
gi 194713878   86 PTAAIKLSQEYELAVWKKEDF 106
Cdd:TIGR01971  95 PTDAIVLTPEFELATYTRSDL 115
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 37-105 2.09e-17

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 72.47  E-value: 2.09e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194713878  37 PQQCIGCAACVNACPSNALTVETDlaTNELAWQFNLSRCIFCGRCEEVCPTAAIKLSQeYELAVWKKED 105
Cdd:COG1143    1 EDKCIGCGLCVRVCPVDAITIEDG--EPGKVYVIDPDKCIGCGLCVEVCPTGAISMTP-FELAVEDREE 66
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 40-89 1.60e-10

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 54.07  E-value: 1.60e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 194713878   40 CIGCAACVNACPSNALTV-ETDLATNELAWQFNLSRCIFCGRCEEVCPTAA 89
Cdd:pfam12838   1 CIGCGACVAACPVGAITLdEVGEKKGTKTVVIDPERCVGCGACVAVCPTGA 51
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 40-90 6.26e-05

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 42.15  E-value: 6.26e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 194713878  40 CIGCAACVNACPSNALTVEtdlaTNELAWQfnlSRCIFCGRCEEVCPTAAI 90
Cdd:NF038196 187 CIGCGICAKVCPVNNIEME----DGKPVWG---HNCTHCLACIHRCPKEAI 230
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 73-104 5.40e-03

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 36.38  E-value: 5.40e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 194713878  73 SRCIFCGRCEEVCPTAAIKLSQEYelAVWKKE 104
Cdd:NF038196 185 DKCIGCGICAKVCPVNNIEMEDGK--PVWGHN 214
 
Name Accession Description Interval E-value
PRK12387 PRK12387
formate hydrogenlyase complex iron-sulfur subunit; Provisional
 1-180 5.74e-122

formate hydrogenlyase complex iron-sulfur subunit; Provisional


Pssm-ID: 183492 [Multi-domain]  Cd Length: 180  Bit Score: 341.24  E-value: 5.74e-122
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194713878   1 MFTFIKKVIKTGTATSSYPLEPIAVDKNFRGKPEHNPQQCIGCAACVNACPSNALTVETDLATNELAWQFNLSRCIFCGR 80
Cdd:PRK12387   1 MFKLIKKVIKTGTATSSYPLEPIAVDKNFRGKPEYNPQQCIGCAACVNACPSNALTVETDLATGELAWEFNLGRCIFCGR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194713878  81 CEEVCPTAAIKLSQEYELAVWKKEDFLQQSRFALCNCRVCNRPFAVQKEIDYAIALLAHNGDSRAENHRESFETCPDCKR 160
Cdd:PRK12387  81 CEEVCPTAAIKLSQEFELAVWKKEDLLQQSEFALCNCRVCGRPFAVQKEIDYAIALLKHNGDSRAENHRESFETCPECKR 160

                        170       180
                 ....*....|....*....|
gi 194713878 161 QKCLVPSDRIELTRHMKEVS 180
Cdd:PRK12387 161 QKCLVPSDRIELTRHMKEAI 180
PRK08222 PRK08222
hydrogenase 4 subunit H; Validated
 1-180 2.73e-70

hydrogenase 4 subunit H; Validated


Pssm-ID: 181301 [Multi-domain]  Cd Length: 181  Bit Score: 210.76  E-value: 2.73e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194713878   1 MFTFIKKVIKTGTATSSYPLEPIAVDKNFRGKPEHNPQQCIGCAACVNACPSNALTVETDLATNELAWQFNLSRCIFCGR 80
Cdd:PRK08222   1 MLKLLKTIMRAGTATVKYPFAPLEVSPGFRGKPDLMPSQCIACGACTCACPANALTIQTDDQQNSRTWQLYLGRCIYCGR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194713878  81 CEEVCPTAAIKLSQEYELAVWKKEDFLQQSRFALCNCRVCNRPFAVQKEIDYAIALLAH--NGDSRAENHRESFETCPDC 158
Cdd:PRK08222  81 CEEVCPTRAIQLTNNFELTVTNKADLYTRATFHLQRCSRCERPFAPQKTVALAAELLAQqqNAPQNREMLRAQASVCPEC 160

                        170       180
                 ....*....|....*....|..
gi 194713878 159 KRQKCLVpSDRIELTRHMKEVS 180
Cdd:PRK08222 161 KQRATLI-NDDTDVPLVAKEQL 181
PRK05888 PRK05888
NADH-quinone oxidoreductase subunit NuoI;
3-107 3.05e-22

NADH-quinone oxidoreductase subunit NuoI;


Pssm-ID: 235637 [Multi-domain]  Cd Length: 164  Bit Score: 87.63  E-value: 3.05e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194713878   3 TFIKKVIktgtaTSSYPLEPIAVDKNFRG-----KPEHNPQQCIGCAACVNACPSNALTVETDLATN---ELAW-QFNLS 73
Cdd:PRK05888  23 YFFKKKV-----TIQYPEEKLPLSPRFRGrhalrRDPNGEERCIACKLCAAICPADAITIEAAEREDgrrRTTRyDINFG 97

                         90       100       110
                 ....*....|....*....|....*....|....
gi 194713878  74 RCIFCGRCEEVCPTAAIKLSQEYELAVWKKEDFL 107
Cdd:PRK05888  98 RCIFCGFCEEACPTDAIVETPDFELATETREELI 131
MtMvhB_like cd10549
Uncharacterized polyferredoxin-like protein; This family contains uncharacterized ...
 33-173 1.24e-21

Uncharacterized polyferredoxin-like protein; This family contains uncharacterized polyferredoxin protein similar to Methanobacterium thermoautotrophicum MvhB. The mvhB is a gene of the methylviologen-reducing hydrogenase operon. It is predicted to contain 12 [4Fe-4S] clusters, and was therefore suggested to be a polyferredoxin. As a subfamily of the beta subunit of the DMSO Reductase (DMSOR) family, it is predicted to function as electron carrier in the reducing reaction.


Pssm-ID: 319871 [Multi-domain]  Cd Length: 128  Bit Score: 85.14  E-value: 1.24e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194713878  33 PEHNPQQCIGCAACVNACPSNALTVETDLATNELaWQFNLSRCIFCGRCEEVCPTAAIKLSQEY-ELAVWKKEDFLQQSR 111
Cdd:cd10549    1 LKYDPEKCIGCGICVKACPTDAIELGPNGAIARG-PEIDEDKCVFCGACVEVCPTGAIELTPEGkEYVPKEKEAEIDEEK 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 194713878 112 faLCNCRVCNRPFAVQkeidyAIALlahngdSRAENHRESFETCPDCKR--QKClvPSDRIELT 173
Cdd:cd10549   80 --CIGCGLCVKVCPVD-----AITL------EDELEIVIDKEKCIGCGIcaEVC--PVNAIKLV 128
NuoI TIGR01971
NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of ...
 15-106 1.01e-20

NADH-quinone oxidoreductase, chain I; This model represents the I subunit (one of 14: A->N) of the NADH-quinone oxidoreductase complex I which generally couples NADH and ubiquinone oxidation/reduction in bacteria and mammalian mitochondria, but may act on NADPH and/or plastoquinone in cyanobacteria and plant chloroplasts. This model excludes "I" subunits from the closely related F420H2 dehydrogenase and formate hydrogenlyase complexes. [Energy metabolism, Electron transport]


Pssm-ID: 273902 [Multi-domain]  Cd Length: 122  Bit Score: 82.46  E-value: 1.01e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194713878   15 TSSYPLEPIAVDKNFRG-----KPEHNPQQCIGCAACVNACPSNALTVET----DLATNELAWQFNLSRCIFCGRCEEVC 85
Cdd:TIGR01971  15 TVQYPEEKLYLPPRFRGrivltRDPNGEEKCIGCTLCAAVCPADAIRVVPaegeDGKRRLKFYEINFGRCIFCGLCEEAC 94

                          90       100
                  ....*....|....*....|.
gi 194713878   86 PTAAIKLSQEYELAVWKKEDF 106
Cdd:TIGR01971  95 PTDAIVLTPEFELATYTRSDL 115
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 37-105 2.09e-17

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 72.47  E-value: 2.09e-17
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194713878  37 PQQCIGCAACVNACPSNALTVETDlaTNELAWQFNLSRCIFCGRCEEVCPTAAIKLSQeYELAVWKKED 105
Cdd:COG1143    1 EDKCIGCGLCVRVCPVDAITIEDG--EPGKVYVIDPDKCIGCGLCVEVCPTGAISMTP-FELAVEDREE 66
PRK08348 PRK08348
NADH-plastoquinone oxidoreductase subunit; Provisional
 1-105 3.78e-17

NADH-plastoquinone oxidoreductase subunit; Provisional


Pssm-ID: 181399 [Multi-domain]  Cd Length: 120  Bit Score: 73.33  E-value: 3.78e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194713878   1 MFTFIKKVIKTGT---ATSSYP-LEPIAVDKNFRGKPEHNPQQCIGCAACVNACPSNALTVETDLATNELaWqfnLSRCI 76
Cdd:PRK08348   1 RLPLLPTVLRNLFkkpATNLFPaTEPVPVPEDFRGKILYDVDKCVGCRMCVTVCPAGVFVYLPEIRKVAL-W---TGRCV 76

                         90       100
                 ....*....|....*....|....*....
gi 194713878  77 FCGRCEEVCPTAAIKLSQEYELAVWKKED 105
Cdd:PRK08348  77 FCGQCVDVCPTGALQMSDDFLLASYDRFD 105
ndhI TIGR00403
NADH-plastoquinone oxidoreductase subunit I protein; [Energy metabolism, Electron transport]
 15-106 8.80e-15

NADH-plastoquinone oxidoreductase subunit I protein; [Energy metabolism, Electron transport]


Pssm-ID: 129498 [Multi-domain]  Cd Length: 183  Bit Score: 68.79  E-value: 8.80e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194713878   15 TSSYPLEPIAVDKNFRGKPEHNPQQCIGCAACVNACPSNALTV----ETDLATNELA-WQFNLSRCIFCGRCEEVCPTAA 89
Cdd:TIGR00403  39 TIQYPYEKLIPSERFRGRIHFEFDKCIACEVCVRVCPINLPVVdwefNKAIKKKQLKnYSIDFGVCIFCGNCVEYCPTNC 118

                          90
                  ....*....|....*..
gi 194713878   90 IKLSQEYELAVWKKEDF 106
Cdd:TIGR00403 119 LSMTEEYELSTYDRHEL 135
ndhI CHL00014
NADH dehydrogenase subunit I
 15-101 3.32e-14

NADH dehydrogenase subunit I


Pssm-ID: 214334 [Multi-domain]  Cd Length: 167  Bit Score: 66.71  E-value: 3.32e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194713878  15 TSSYPLEPIAVDKNFRGKPEHNPQQCIGCAACVNACPSNALTVETDLATN-----ELAWQFNLSRCIFCGRCEEVCPTAA 89
Cdd:CHL00014  36 TIQYPYEKLITSERFRGRIHFEFDKCIACEVCVRVCPIDLPVVDWKLETDirkkrLLNYSIDFGVCIFCGNCVEYCPTNC 115

                         90
                 ....*....|..
gi 194713878  90 IKLSQEYELAVW 101
Cdd:CHL00014 116 LSMTEEYELSTY 127
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
31-103 2.86e-13

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 61.67  E-value: 2.86e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194713878  31 GKPEHNPQQCIGCAACVNACPSNALTVETDlatnelAWQFNLSRCIFCGRCEEVCPTAAIKLSQEYELAVWKK 103
Cdd:COG2768    4 GKPYVDEEKCIGCGACVKVCPVGAISIEDG------KAVIDPEKCIGCGACIEVCPVGAIKIEWEEDEEFQEK 70
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 32-94 1.20e-12

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 60.06  E-value: 1.20e-12
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194713878  32 KPEHNPQQCIGCAACVNACPSNALTVETDLATnelawqFNLSRCIFCGRCEEVCPTAAIKLSQ 94
Cdd:COG2221    9 PPKIDEEKCIGCGLCVAVCPTGAISLDDGKLV------IDEEKCIGCGACIRVCPTGAIKGEK 65
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 30-92 5.40e-11

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 55.50  E-value: 5.40e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194713878  30 RGKPEHNPQQCIGCAACVNACPSNALTVEtdlatNELAWQFNLSRCIFCGRCEEVCPTAAIKL 92
Cdd:COG1149    3 RKIPVIDEEKCIGCGLCVEVCPEGAIKLD-----DGGAPVVDPDLCTGCGACVGVCPTGAITL 60
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 32-97 1.53e-10

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 55.06  E-value: 1.53e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194713878  32 KPEHNPQQCIGCAACVNACPSNALTVEtdlatNELAWQFNLSRCIFCGRCEEVCPTAAIKLSQEYE 97
Cdd:COG1144   24 RPVVDEDKCIGCGLCWIVCPDGAIRVD-----DGKYYGIDYDYCKGCGICAEVCPVKAIEMVPEEK 84
Fer4_7 pfam12838
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 40-89 1.60e-10

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 463724 [Multi-domain]  Cd Length: 51  Bit Score: 54.07  E-value: 1.60e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 194713878   40 CIGCAACVNACPSNALTV-ETDLATNELAWQFNLSRCIFCGRCEEVCPTAA 89
Cdd:pfam12838   1 CIGCGACVAACPVGAITLdEVGEKKGTKTVVIDPERCVGCGACVAVCPTGA 51
PreA COG1146
NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and ...
 36-100 1.91e-10

NAD-dependent dihydropyrimidine dehydrogenase, PreA subunit [Nucleotide transport and metabolism];


Pssm-ID: 440761 [Multi-domain]  Cd Length: 67  Bit Score: 54.33  E-value: 1.91e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194713878  36 NPQQCIGCAACVNACPSNALTVETDLATnelAWQFNLSRCIFCGRCEEVCPTAAIKLSQEYELAV 100
Cdd:COG1146    6 DTDKCIGCGACVEVCPVDVLELDEEGKK---ALVINPEECIGCGACELVCPVGAITVEDDEPEEQ 67
NapF COG1145
Ferredoxin [Energy production and conversion];
32-92 8.48e-10

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 55.88  E-value: 8.48e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 194713878  32 KPEHNPQQCIGCAACVNACPSNALTvetdLATNELAWQFNLSRCIFCGRCEEVCPTAAIKL 92
Cdd:COG1145  176 KAVIDAEKCIGCGLCVKVCPTGAIR----LKDGKPQIVVDPDKCIGCGACVKVCPVGAISL 232
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
30-100 8.59e-10

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 54.28  E-value: 8.59e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194713878  30 RGKPEHNPQQCIGC--AACVNACPSNALTVETDlatnelAWQFNLSRCIFCGRCEEVCPTAAIKLSQEYELAV 100
Cdd:COG1142   42 RKAGVSAPVQCRHCedAPCAEVCPVGAITRDDG------AVVVDEEKCIGCGLCVLACPFGAITMVGEKSRAV 108
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 36-95 3.31e-09

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 51.20  E-value: 3.31e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 194713878  36 NPQQCIGCAACVNACPSNALTVETDLAtnelawQFNLSRCIFCGRCEEVCPTAAIKLSQE 95
Cdd:COG4231   20 DEDKCTGCGACVKVCPADAIEEGDGKA------VIDPDLCIGCGSCVQVCPVDAIKLEKR 73
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
22-91 3.91e-09

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 54.65  E-value: 3.91e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194713878  22 PIAVDKNFRGKPEHNPQQCIGCAACVNACPSNALTVETDLATnelawqFNLSRCIFCGRCEEVCPTAAIK 91
Cdd:COG4624   75 GIIIIDKRGPSIIRDKEKCKNCYPCVRACPVKAIKVDDGKAE------IDEEKCISCGQCVAVCPFGAIT 138
RnfC COG4656
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfC subunit [Energy production and ...
 33-104 7.12e-09

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfC subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfC subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 443694 [Multi-domain]  Cd Length: 451  Bit Score: 53.99  E-value: 7.12e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194713878  33 PEHNPQQCIGCAACVNACPSNaltvetdLATNELAW-----------QFNLSRCIFCGRCEEVCPtAAIKLSQEYELAvw 101
Cdd:COG4656  359 PPPEEQPCIRCGRCVDACPMG-------LLPQQLYWyaragdfdkaeEYNLMDCIECGCCSYVCP-SKIPLVQYIRLA-- 428


                 ...
gi 194713878 102 KKE 104
Cdd:COG4656  429 KAE 431
PRK13795 PRK13795
hypothetical protein; Provisional
 40-91 1.13e-08

hypothetical protein; Provisional


Pssm-ID: 237510 [Multi-domain]  Cd Length: 636  Bit Score: 53.46  E-value: 1.13e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 194713878  40 CIGCAACVNACPSNALTVETDLATNELAWqfnlSRCIFCGRCEEVCPTAAIK 91
Cdd:PRK13795 583 CVGCGVCVGACPTGAIRIEEGKRKISVDE----EKCIHCGKCTEVCPVVKYK 630
PRK13984 PRK13984
putative oxidoreductase; Provisional
 29-107 1.41e-08

putative oxidoreductase; Provisional


Pssm-ID: 172486 [Multi-domain]  Cd Length: 604  Bit Score: 53.23  E-value: 1.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194713878  29 FRGKPEHNPQQCIGCAACVNACPSNALT-VET-DLATNE----LAWQFNLSRCIFCGRCEEVCPTAAIKLSQEYELAVWK 102
Cdd:PRK13984  36 YRGFHINDWEKCIGCGTCSKICPTDAITmVEVpDLPQEYgkkpQRPVIDYGRCSFCALCVDICTTGSLKMTREYIHISPD 115


                 ....*
gi 194713878 103 KEDFL 107
Cdd:PRK13984 116 PEDFI 120
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
32-93 1.50e-08

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 52.37  E-value: 1.50e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 194713878  32 KPEHNPQQCIGCAACVNACPsnaltVETDLATNELawqfNLSRCIFCGRCEEVCPTAAIKLS 93
Cdd:COG0348  204 RVRYDRGDCIDCGLCVKVCP-----MGIDIRKGEI----NQSECINCGRCIDACPKDAIRFS 256
rnfC TIGR01945
electron transport complex, RnfABCDGE type, C subunit; The six subunit complex RnfABCDGE in ...
 33-99 2.99e-08

electron transport complex, RnfABCDGE type, C subunit; The six subunit complex RnfABCDGE in Rhodobacter capsulatus encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation. A closely related complex in E. coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containing superoxide sensor SoxR, active as a transcription factor when oxidized. This family of putative NADH oxidoreductase complexes exists in many of the same species as the related NQR, a Na(+)-translocating NADH-quinone reductase, but is distinct. This model describes the C subunit. [Energy metabolism, Electron transport]


Pssm-ID: 273888 [Multi-domain]  Cd Length: 435  Bit Score: 51.96  E-value: 2.99e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194713878   33 PEHNPQQCIGCAACVNACPSNaltvetdLATNELAW-----------QFNLSRCIFCGRCEEVCPtAAIKLSQEYELA 99
Cdd:TIGR01945 358 PESPEKPCIRCGKCVQVCPMN-------LLPQQLNWlaladefdeaeEHNLMDCIECGCCSYVCP-SNIPLVQYIRQA 427
Fer4_10 pfam13237
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 32-86 3.29e-08

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 404174 [Multi-domain]  Cd Length: 56  Bit Score: 48.02  E-value: 3.29e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 194713878   32 KPEHNPQQCIGCAACVNACPSNALTVETDLATNELAWQ-FNLSRCIFCGRCEEVCP 86
Cdd:pfam13237   1 KVVIDPDKCIGCGRCTAACPAGLTRVGAIVERLEGEAVrIGVWKCIGCGACVEACP 56
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
40-90 9.77e-08

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 50.32  E-value: 9.77e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 194713878  40 CIGCAACVNACPSNALTVETDLAtnelawQFNLSRCIFCGRCEEVCPTAAI 90
Cdd:PRK07118 215 CIGCGKCVKACPAGAITMENNLA------VIDQEKCTSCGKCVEKCPTKAI 259
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
33-92 1.13e-07

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 50.63  E-value: 1.13e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 194713878  33 PEHNPQQCIGCAACVNACPSNALTVETDLATnelawQFNLSRCIFCGRCEEVCPTAAIKL 92
Cdd:COG1148  491 AEVDPEKCTGCGRCVEVCPYGAISIDEKGVA-----EVNPALCKGCGTCAAACPSGAISL 545
Fer4_9 pfam13187
4Fe-4S dicluster domain;
39-90 1.63e-07

4Fe-4S dicluster domain;


Pssm-ID: 463801 [Multi-domain]  Cd Length: 50  Bit Score: 46.01  E-value: 1.63e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 194713878   39 QCIGCAACVNACPSNALTVETDLATNELAWQFNlsRCIFCGRCEEVCPTAAI 90
Cdd:pfam13187   1 KCTGCGACVAACPAGAIVPDLVGQTIRGDIAGL--ACIGCGACVDACPRGAI 50
PRK09898 PRK09898
ferredoxin-like protein;
38-92 2.72e-07

ferredoxin-like protein;


Pssm-ID: 182135 [Multi-domain]  Cd Length: 208  Bit Score: 48.68  E-value: 2.72e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 194713878  38 QQCIGCAACVNACPSNALTVETDLATNelawqfnlSRCIFCGRCEEVCPTAAIKL 92
Cdd:PRK09898 154 KRCIGCSACTTACPWMMATVNTESKKS--------SKCVLCGECANACPTGALKI 200
Rama_corrin_act TIGR04270
methylamine methyltransferase corrinoid protein reductive activase; Members of this family ...
 40-94 3.46e-07

methylamine methyltransferase corrinoid protein reductive activase; Members of this family occur as paralogs in species capable of generating methane from mono-, di-, and tri-methylamine. Members include RamA (Reductive Activation of Methyltransfer, Amines) from Methanosarcina barkeri MS (DSM 800). Member proteins have two C-terminal motifs with four Cys each, likely to bind one 4Fe-4S cluster per motif.


Pssm-ID: 211993 [Multi-domain]  Cd Length: 535  Bit Score: 48.99  E-value: 3.46e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 194713878   40 CIGCAACVNACPSNALTV-ETDLATnelawqFNLSRCI--FCGRCEEVCPTAAIKLSQ 94
Cdd:TIGR04270 481 CIACQKCVKECPGKALSIlESEPPR------IDTDRCLgtACRRCERVCPEKVFDIRN 532
PRK05035 PRK05035
electron transport complex protein RnfC; Provisional
 33-113 7.26e-07

electron transport complex protein RnfC; Provisional


Pssm-ID: 235334 [Multi-domain]  Cd Length: 695  Bit Score: 48.02  E-value: 7.26e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194713878  33 PEHNPQQ-CIGCAACVNACPSnaltvetDLATNELAW-----------QFNLSRCIFCGRCEEVCPtAAIKLSQEYELA- 99
Cdd:PRK05035 364 PPPPPEQpCIRCGACADACPA-------SLLPQQLYWfakaeehdkaqEYNLFDCIECGACAYVCP-SNIPLVQYYRQAk 435

                         90
                 ....*....|....*.
gi 194713878 100 --VWKKEDFLQQSRFA 113
Cdd:PRK05035 436 aeIRAIEQEKKKAEEA 451
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 38-95 9.18e-07

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 46.08  E-value: 9.18e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 194713878  38 QQCIGCAACVNACPSNALTV------ETDLATNElawqfnlsrCIFCGRCEEVCPTAAIKLSQE 95
Cdd:cd10564   13 DLCTRCGDCVEACPEGIIVRgdggfpELDFSRGE---------CTFCGACAEACPEGALDPARE 67
RnfB COG2878
Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and ...
 40-160 2.48e-06

Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit [Energy production and conversion]; Na+-translocating ferredoxin:NAD+ oxidoreductase RNF, RnfB subunit is part of the Pathway/BioSystem: Na+-translocating Fd:NADH oxidoreductase


Pssm-ID: 442125 [Multi-domain]  Cd Length: 254  Bit Score: 46.14  E-value: 2.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194713878  40 CIGCAACVNACPSNALTVETD-LATnelawqFNLSRCIFCGRCEEVCPTAAIKL---SQEYELAVWKKEDFLQQSRFALC 115
Cdd:COG2878  139 CIGCGDCIKACPFDAIVGAAKgMHT------VDEDKCTGCGLCVEACPVDCIEMvpvSPTVVVSSWDKGKAVRKVVGCIG 212

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 194713878 116 NCRVCNRPFAvqkeIDYAIALLAHNGDSRAENHRESFETCPDCKR 160
Cdd:COG2878  213 LCCKKCCPAA----AITVNNLAAIIDYKKCTCCGCCEKCCPTAII 253
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 24-92 2.65e-06

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 44.63  E-value: 2.65e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194713878  24 AVDKNFRGKPEHNPQQCIGCAACVNACPSNALTVETDLATNelawqfnlSRCIFCGRCEEVCPTAAIKL 92
Cdd:cd16372   63 AITRDANGVVMINKKLCVGCLMCVGFCPEGAMFKHEDYPEP--------FKCIACGICVKACPTGALEL 123
PRK12771 PRK12771
putative glutamate synthase (NADPH) small subunit; Provisional
 39-95 2.67e-06

putative glutamate synthase (NADPH) small subunit; Provisional


Pssm-ID: 237198 [Multi-domain]  Cd Length: 564  Bit Score: 46.41  E-value: 2.67e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 194713878  39 QCIGCAACVNACPSNALT-VETdlatnELAWQFNLSRCIFCGRCEEVCPTAAIKLSQE 95
Cdd:PRK12771 511 NCFECDNCYGACPQDAIIkLGP-----GRRYHFDYDKCTGCHICADVCPCGAIEMGPG 563
ACS_1 cd01916
Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and ...
 39-87 3.42e-06

Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA. ACS forms a heterotetramer with carbon monoxide dehydrogenase (CODH) consisting of two ACS and two CODH subunits. CODH reduces carbon dioxide to carbon monoxide and ACS then synthesizes acetyl-CoA from carbon monoxide, CoA, and a methyl group donated by another protein (CoFeSP). ACS has three structural domains, an N-terminal rossman fold domain with a helical region at its N-terminus which interacts with CODH, and two alpha + beta fold domains. A Ni-Fe-S center referred to as the A-cluster is located in the C-terminal domain. A large cavity exists between the three domains which may bind CoA.


Pssm-ID: 238897 [Multi-domain]  Cd Length: 731  Bit Score: 46.25  E-value: 3.42e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 194713878  39 QCIGCAACVNACPsNALTVETdlaTNELAWQFNLS-------RCIFCGRCEEVCPT 87
Cdd:cd01916  366 KCTDCGWCTRACP-NSLRIKE---AMEAAKEGDFSgladlfdQCVGCGRCEQECPK 417
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 37-100 3.78e-06

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 44.30  E-value: 3.78e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194713878  37 PQQCIGC--AACVNACPSNALTVETDLATnelawQFNLSRCIFCGRCEEVCPTAAIKLSQEYELAV 100
Cdd:cd04410   47 PVSCMHCedPPCVKACPTGAIYKDEDGIV-----LIDEDKCIGCGSCVEACPYGAIVFDPEPGKAV 107
PRK06273 PRK06273
ferredoxin; Provisional
 40-86 3.84e-06

ferredoxin; Provisional


Pssm-ID: 235764 [Multi-domain]  Cd Length: 165  Bit Score: 44.70  E-value: 3.84e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 194713878  40 CIGCAACVNACPSNALTVE-------TDLATNELAWQFNLSRCIFCGRCEEVCP 86
Cdd:PRK06273  51 CIGCGGCANVCPTKAIEMIpvepvkiTEGYVKTKIPKIDYEKCVYCLYCHDFCP 104
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 40-91 3.93e-06

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 44.55  E-value: 3.93e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 194713878  40 CIGCAACVNACPSNALTVETDLATNELAWQ----FNLSRCIFCG-RCEEVCPTAAIK 91
Cdd:cd16373   16 CIRCGLCVEACPTGVIQPAGLEDGLEGGRTpyldPREGPCDLCCdACVEVCPTGALR 72
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
 36-111 6.17e-06

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 45.51  E-value: 6.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194713878  36 NPQQCIGCAACVNACPSNALTVETdlaTNELAWQFNLS--RCIFC-GR-----CEEVCPTAAIKLSQEYELAVWKKEDFL 107
Cdd:PRK12769  83 NQQKCIGCKSCVVACPFGTMQIVL---TPVAAGKVKATahKCDLCaGRengpaCVENCPADALQLVTEQALSGMAKSRRL 159


                 ....
gi 194713878 108 QQSR 111
Cdd:PRK12769 160 RTAR 163
GlpC COG0247
Fe-S cluster-containing oxidoreductase, includes glycolate oxidase subunit GlcF [Energy ...
 39-86 7.22e-06

Fe-S cluster-containing oxidoreductase, includes glycolate oxidase subunit GlcF [Energy production and conversion];


Pssm-ID: 440017 [Multi-domain]  Cd Length: 420  Bit Score: 45.07  E-value: 7.22e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194713878  39 QCIGCAACVNACPSNALT------------VETDLATNELAWQFN------LSRCIFCGRCEEVCP 86
Cdd:COG0247   79 ACVGCGFCRAMCPSYKATgdekdsprgrinLLREVLEGELPLDLSeevyevLDLCLTCKACETACP 144
PRK12809 PRK12809
putative oxidoreductase Fe-S binding subunit; Reviewed
 36-92 9.24e-06

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183762 [Multi-domain]  Cd Length: 639  Bit Score: 45.02  E-value: 9.24e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 194713878  36 NPQQCIGC--AACVNACPSNALTVETDlatnelAWQFNLSRCIFCGRCEEVCPTAAIKL 92
Cdd:PRK12809  52 NPVACHHCnnAPCVTACPVNALTFQSD------SVQLDEQKCIGCKRCAIACPFGVVEM 104
porD PRK09625
pyruvate flavodoxin oxidoreductase subunit delta; Reviewed
 32-105 1.38e-05

pyruvate flavodoxin oxidoreductase subunit delta; Reviewed


Pssm-ID: 236596 [Multi-domain]  Cd Length: 133  Bit Score: 42.81  E-value: 1.38e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194713878  32 KPEHNPQQCIGCAACVNACPSNALtvetdLATNELAWQFNLSRCIFCGRCEEVCPTAAIKL-------SQEYELAVW-KK 103
Cdd:PRK09625  53 KPVHNNEICINCFNCWVYCPDAAI-----LSRDKKLKGVDYSHCKGCGVCVEVCPTNPKSLlmfeeqiENETALTQWpKK 127


                 ..
gi 194713878 104 ED 105
Cdd:PRK09625 128 EE 129
HycB COG1142
Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];
31-92 1.42e-05

Fe-S-cluster-containing hydrogenase component 2 [Energy production and conversion];


Pssm-ID: 440757 [Multi-domain]  Cd Length: 138  Bit Score: 42.72  E-value: 1.42e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194713878  31 GKPEHNPQQCIGCAACVNACPSNALTVETDLATNElawqfnLSRCIFCG------RCEEVCPTAAIKL 92
Cdd:COG1142   74 GAVVVDEEKCIGCGLCVLACPFGAITMVGEKSRAV------AVKCDLCGgreggpACVEACPTGALRL 135
napF TIGR00402
ferredoxin-type protein NapF; The gene codes for a ferredoxin-type cytosolic protein, NapF, of ...
 29-90 1.65e-05

ferredoxin-type protein NapF; The gene codes for a ferredoxin-type cytosolic protein, NapF, of the periplasmic nitrate reductase system, as in Escherichia coli. NapF interacts with the catalytic subunit, NapA, and may be an accessory protein for NapA maturation. [Energy metabolism, Electron transport]


Pssm-ID: 273060 [Multi-domain]  Cd Length: 101  Bit Score: 41.86  E-value: 1.65e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 194713878   29 FRGKPEHNPQQCIGCAACVNACPSNALTVEtdlATNELAWQFNLSRCIFCGRCEEVCPTAAI 90
Cdd:TIGR00402  25 WSARESLFSAVCTRCGECASACENNILQLG---QQGQPTVEFDNAECDFCGKCAEACPTNAF 83
SdhB/FrdB COG0479
Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and ...
 39-90 1.69e-05

Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440247 [Multi-domain]  Cd Length: 230  Bit Score: 43.58  E-value: 1.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194713878  39 QCIGCAACVNACPSnaltVETDL------ATNeLAWQFN--------------------LSRCIFCGRCEEVCP-----T 87
Cdd:COG0479  143 ECILCGACVAACPN----VWANPdflgpaALA-QAYRFAldprdeeteerlealedeegVWRCTTCGNCTEVCPkgippT 217


                 ...
gi 194713878  88 AAI 90
Cdd:COG0479  218 KAI 220
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 31-90 2.31e-05

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 42.23  E-value: 2.31e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194713878  31 GKPEHNPQQ--CIGCAACVNACPSNALTvetdlATNELAWQFNLS---RC-----IFCGRCEEVCPTAAI 90
Cdd:cd10564   36 GFPELDFSRgeCTFCGACAEACPEGALD-----PAREAPWPLRAEigdSClalqgVECRSCQDACPTQAI 100
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 23-95 2.51e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 41.79  E-value: 2.51e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194713878  23 IAVDKNFRgKPEHNPQQCIGC--AACVNACPSNALTVetDLATNelAWQFNLSRCIFCGRCEEVCPTAAIKLSQE 95
Cdd:cd10550   33 IRVVRFEP-EGLDVPVVCRQCedAPCVEACPVGAISR--DEETG--AVVVDEDKCIGCGMCVEACPFGAIRVDPE 102
PRK14028 PRK14028
pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional
 32-95 4.61e-05

pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional


Pssm-ID: 172522 [Multi-domain]  Cd Length: 312  Bit Score: 42.68  E-value: 4.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194713878  32 KPEHNPQQCIGCAACVNACPSNALtVEtdlatnelAWQ----------------FNLSRCIFCGRCEEVCPTAAIKLSQE 95
Cdd:PRK14028 241 KPVIDHSKCIMCRKCWLYCPDDAI-IE--------AWReaegprgrkfrmkmidFDYQYCKGCGVCAEVCPTGAIQMVRE 311
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 38-91 4.90e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 41.47  E-value: 4.90e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 194713878  38 QQCIGCAACVNACPSNAltVETDLATNELAWQFNLSRCIFCGRCEEVCPT---AAIK 91
Cdd:cd16373   97 QGGTDCGVCVEACPTEA--IAIVLEDDVLRPVVDEDKCVGCGLCEYVCPVeppKAIV 151
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 43-98 5.10e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 41.47  E-value: 5.10e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194713878  43 CAACVNACPSNALTVETDLATNE---LAwQFNLSRCI------FCGRCEEVCPTAAIKLSQEYEL 98
Cdd:cd16373   59 CDACVEVCPTGALRPLDLEEQKVkmgVA-VIDKDRCLawqggtDCGVCVEACPTEAIAIVLEDDV 122
psaC CHL00065
photosystem I subunit VII
 40-87 5.67e-05

photosystem I subunit VII


Pssm-ID: 177005 [Multi-domain]  Cd Length: 81  Bit Score: 39.74  E-value: 5.67e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 194713878  40 CIGCAACVNACPSNAL-TVETD-LATNELAWQFNLSRCIFCGRCEEVCPT 87
Cdd:CHL00065  11 CIGCTQCVRACPTDVLeMIPWDgCKAKQIASAPRTEDCVGCKRCESACPT 60
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 40-90 6.26e-05

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 42.15  E-value: 6.26e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 194713878  40 CIGCAACVNACPSNALTVEtdlaTNELAWQfnlSRCIFCGRCEEVCPTAAI 90
Cdd:NF038196 187 CIGCGICAKVCPVNNIEME----DGKPVWG---HNCTHCLACIHRCPKEAI 230
DMSOR_beta_like cd10550
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 40-92 7.16e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319872 [Multi-domain]  Cd Length: 130  Bit Score: 40.64  E-value: 7.16e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 194713878  40 CIGCAACVNACPSNALTV--ETDLAtnelawqfnlSRCIFCG---RCEEVCPTAAIKL 92
Cdd:cd10550   82 CIGCGMCVEACPFGAIRVdpETGKA----------IKCDLCGgdpACVKVCPTGALEF 129
PRK00783 PRK00783
DNA-directed RNA polymerase subunit D; Provisional
 40-93 9.02e-05

DNA-directed RNA polymerase subunit D; Provisional


Pssm-ID: 234837 [Multi-domain]  Cd Length: 263  Bit Score: 41.41  E-value: 9.02e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 194713878  40 CIGCAACVNACPSNALTVETDLATNElawqfNLSRCIFCGRCEEVCPTAAIKLS 93
Cdd:PRK00783 171 CDECEKCVEACPRGVLELKEGKLVVT-----DLLNCSLCKLCERACPGKAIRVS 219
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
31-92 9.07e-05

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 41.46  E-value: 9.07e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194713878  31 GKPEHNPQQCIGCAACVNACPSNALTVETDlatNELAWQFNLSR-------------CIFCGRCEEVCPTAAIKL 92
Cdd:PRK07118 161 GLPVVDEDKCTGCGACVKACPRNVIELIPK---SARVFVACNSKdkgkavkkvcevgCIGCGKCVKACPAGAITM 232
DMSOR_beta_like cd16374
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 37-100 9.84e-05

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319896 [Multi-domain]  Cd Length: 139  Bit Score: 40.34  E-value: 9.84e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194713878  37 PQQCIGC--AACVNACPSNALTVETDLATnelawQFNLSRCIFCGRCEEVCPTAAIKLSQEYELAV 100
Cdd:cd16374   40 PVRCRHCedAPCMEVCPTGAIYRDEDGAV-----LVDPDKCIGCGMCAMACPFGVPRFDPSLKVAV 100
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 34-92 1.15e-04

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 40.07  E-value: 1.15e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194713878  34 EHNPQQCIGCAACVNACPSNALTVETDLATNElawqfnlsRCIFCG---------RCEEVCPTAAIKL 92
Cdd:cd04410   76 LIDEDKCIGCGSCVEACPYGAIVFDPEPGKAV--------KCDLCGdrldeglepACVKACPTGALTF 135
FDH_b_like cd10562
uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes ...
 38-86 1.30e-04

uncharacterized subfamily of beta subunit of formate dehydrogenase; This subfamily includes the beta-subunit of formate dehydrogenases that are as yet uncharacterized. Members of the DMSO reductase family include formate dehydrogenase N and O (FDH-N, FDH-O) and tungsten-containing formate dehydrogenase (W-FDH) and other similar proteins. FDH-N, a major component of nitrate respiration of Escherichia coli, is involved in the major anaerobic respiratory pathway in the presence of nitrate, catalyzing the oxidation of formate to carbon dioxide at the expense of nitrate reduction to nitrite. It forms a heterotrimer; the alpha-subunit (FDH-G) is the catalytic site of formate oxidation and membrane-associated, incorporating a selenocysteine (SeCys) residue and a [4Fe/4S] cluster in addition to two bis-MGD cofactors, the beta subunit (FDH-H) contains four [4Fe/4S] clusters which transfer the electrons from the alpha subunit to the gamma-subunit (FDH-I), a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. W-FDH contains a tungsten instead of molybdenum at the catalytic center. This enzyme seems to be exclusively found in organisms such as hyperthermophilic archaea that live in extreme environments. It is a heterodimer of a large and a small subunit; the large subunit harbors the W site and one [4Fe-4S] center and the small subunit, containing three [4Fe-4S] clusters, functions to transfer electrons.


Pssm-ID: 319884 [Multi-domain]  Cd Length: 161  Bit Score: 40.36  E-value: 1.30e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 194713878  38 QQCIGC--AACVNACPSNALTVETDLATNelawqFNLSRCIFCGRCEEVCP 86
Cdd:cd10562   68 RQCMHCtdAACVKVCPTGALYKTENGAVV-----VDEDKCIGCGYCVAACP 113
PRK12809 PRK12809
putative oxidoreductase Fe-S binding subunit; Reviewed
 38-104 1.48e-04

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183762 [Multi-domain]  Cd Length: 639  Bit Score: 41.55  E-value: 1.48e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 194713878  38 QQCIGCAACVNACPSNALTVETDLAtnelawqfnlSRCIFCGR-------CEEVCPTAAIKLSQEYELAVWKKE 104
Cdd:PRK12809  85 QKCIGCKRCAIACPFGVVEMVDTIA----------QKCDLCNQrssgtqaCIEVCPTQALRLMDDKGLQQIKVA 148
porD PRK09624
pyruvate ferredoxin oxidoreductase subunit delta; Reviewed
 32-95 1.62e-04

pyruvate ferredoxin oxidoreductase subunit delta; Reviewed


Pssm-ID: 170017 [Multi-domain]  Cd Length: 105  Bit Score: 39.24  E-value: 1.62e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 194713878  32 KPEHNPQQCIGCAACVNACPSNALTVEtdlatNELAWQFNLSRCIFCGRCEEVCPTAAIKLSQE 95
Cdd:PRK09624  45 MPEFNRDKCVRCYLCYIYCPEPAIYLD-----EEGYPVFDYDYCKGCGICANECPTKAIEMVRE 103
COG1149 COG1149
MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function ...
 23-58 1.75e-04

MinD superfamily P-loop ATPase, contains an inserted ferredoxin domain [General function prediction only];


Pssm-ID: 440763 [Multi-domain]  Cd Length: 68  Bit Score: 38.17  E-value: 1.75e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 194713878  23 IAVDKNfrGKPEHNPQQCIGCAACVNACPSNALTVE 58
Cdd:COG1149   28 IKLDDG--GAPVVDPDLCTGCGACVGVCPTGAITLE 61
PRK07118 PRK07118
Fe-S cluster domain-containing protein;
40-92 1.79e-04

Fe-S cluster domain-containing protein;


Pssm-ID: 235941 [Multi-domain]  Cd Length: 280  Bit Score: 40.69  E-value: 1.79e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 194713878  40 CIGCAACVNACPSNALTVETDLAtnelawQFNLSRCIFCGRCEEVCPTAAIKL 92
Cdd:PRK07118 141 CLGLGSCVAACPFDAIHIENGLP------VVDEDKCTGCGACVKACPRNVIEL 187
Fer4_16 pfam13484
4Fe-4S double cluster binding domain;
40-86 1.84e-04

4Fe-4S double cluster binding domain;


Pssm-ID: 463893 [Multi-domain]  Cd Length: 65  Bit Score: 38.24  E-value: 1.84e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194713878   40 CIGCAACVNACPSNAL----------------TVETDLATNELAWQFNLSRCIFCGRCEEVCP 86
Cdd:pfam13484   1 CGSCGKCIDACPTGAIvgpegvldarrcisylTIEKKGLIPDELRCLLGNRCYGCDICQDVCP 63
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 35-91 2.87e-04

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 39.54  E-value: 2.87e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 194713878  35 HNPQQCIGCAACVNACPSNALtvetdlatnelawQFNLSR-----CIFCG---------RCEEVCPTAAIK 91
Cdd:COG0437   87 VDYDKCIGCRYCVAACPYGAP-------------RFNPETgvvekCTFCAdrldegllpACVEACPTGALV 144
HycB_like cd10554
HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a ...
 37-100 3.30e-04

HycB, HydN and similar proteins; This family includes HycB, the FeS subunit of a membrane-associated formate hydrogenlyase system (FHL-1) in Escherichia coli that breaks down formate, produced during anaerobic fermentation, to H2 and CO2. FHL-1 consists of formate dehydrogenase H (FDH-H) and the hydrogenase 3 complex (Hyd-3). HycB is thought to code for the [4Fe-4S] ferredoxin subunit of hydrogenase 3, which functions as an intermediate electron carrier protein between hydrogenase 3 and formate dehydrogenase. HydN codes for the [4Fe-4S] ferredoxin subunit of FDH-H; a hydN in-frame deletion mutation causes only weak reduction in hydrogenase activity, but loss of more than 60% of FDH-H activity. This pathway is only active at low pH and high formate concentrations, and is thought to provide a detoxification/de-acidification system countering the buildup of formate during fermentation.


Pssm-ID: 319876 [Multi-domain]  Cd Length: 149  Bit Score: 39.17  E-value: 3.30e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194713878  37 PQQCIGC--AACVNACPSNALTVETDlatnelAWQFNLSRCIFCGRCEEVCPTAAIKLSQEYELAV 100
Cdd:cd10554   53 PVQCRQCedAPCANVCPVGAISQEDG------VVQVDEERCIGCKLCVLACPFGAIEMAPTTVPGV 112
HybA COG0437
Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and ...
 37-95 3.69e-04

Fe-S-cluster-containing dehydrogenase component (DMSO reductase) [Energy production and conversion];


Pssm-ID: 440206 [Multi-domain]  Cd Length: 184  Bit Score: 39.54  E-value: 3.69e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 194713878  37 PQQCIGC--AACVNACPSNALTVETDLATnelawQFNLSRCIFCGRCEEVCPTAAIKLSQE 95
Cdd:COG0437   57 PVLCNHCddPPCVKVCPTGATYKREDGIV-----LVDYDKCIGCRYCVAACPYGAPRFNPE 112
rnfB TIGR01944
electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in ...
 37-92 3.99e-04

electron transport complex, RnfABCDGE type, B subunit; The six subunit complex RnfABCDGE in Rhodobacter capsulatus encodes an apparent NADH oxidoreductase responsible for electron transport to nitrogenase, necessary for nitrogen fixation. A closely related complex in E. coli, RsxABCDGE (Reducer of SoxR), reduces the 2Fe-2S-containing superoxide sensor SoxR, active as a transcription factor when oxidized. This family of putative NADH oxidoreductase complexes exists in many of the same species as the related NQR, a Na(+)-translocating NADH-quinone reductase, but is distinct. This model describes the B subunit. [Energy metabolism, Electron transport]


Pssm-ID: 273887 [Multi-domain]  Cd Length: 165  Bit Score: 39.01  E-value: 3.99e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 194713878   37 PQQCIGCAACVNACPSNALtvetdLATNELAWQFNLSRCIFCGRCEEVCPTAAIKL 92
Cdd:TIGR01944 112 EDNCIGCTKCIQACPVDAI-----VGAAKAMHTVIADECTGCDLCVEPCPTDCIEM 162
IorA COG4231
TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and ...
 31-62 4.47e-04

TPP-dependent indolepyruvate ferredoxin oxidoreductase, alpha subunit [Energy production and conversion];


Pssm-ID: 443375 [Multi-domain]  Cd Length: 76  Bit Score: 37.33  E-value: 4.47e-04
                         10        20        30
                 ....*....|....*....|....*....|..
gi 194713878  31 GKPEHNPQQCIGCAACVNACPSNALTVETDLA 62
Cdd:COG4231   44 GKAVIDPDLCIGCGSCVQVCPVDAIKLEKRVP 75
PLN00071 PLN00071
photosystem I subunit VII; Provisional
 40-87 4.63e-04

photosystem I subunit VII; Provisional


Pssm-ID: 177700 [Multi-domain]  Cd Length: 81  Bit Score: 37.62  E-value: 4.63e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 194713878  40 CIGCAACVNACPSNAL-TVETD-LATNELAWQFNLSRCIFCGRCEEVCPT 87
Cdd:PLN00071  11 CIGCTQCVRACPTDVLeMIPWDgCKAKQIASAPRTEDCVGCKRCESACPT 60
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 40-95 5.52e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 38.02  E-value: 5.52e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 194713878  40 CIGC--AACVNACPSNALTVETDLATNelawqFNLSRCIFCGRCEEVCPTAAIKLSQE 95
Cdd:cd16370   53 CRACedPPCAEACPTGALEPRKGGGVV-----LDKEKCIGCGNCVKACIVGAIFWDEE 105
HdrA COG1148
Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];
24-58 5.73e-04

Heterodisulfide reductase, subunit A (polyferredoxin) [Energy production and conversion];


Pssm-ID: 440762 [Multi-domain]  Cd Length: 563  Bit Score: 39.46  E-value: 5.73e-04
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 194713878  24 AVDKNFRGKPEHNPQQCIGCAACVNACPSNALTVE 58
Cdd:COG1148  512 AISIDEKGVAEVNPALCKGCGTCAAACPSGAISLK 546
vorD PRK09623
3-methyl-2-oxobutanoate dehydrogenase subunit delta;
13-95 6.70e-04

3-methyl-2-oxobutanoate dehydrogenase subunit delta;


Pssm-ID: 170016 [Multi-domain]  Cd Length: 105  Bit Score: 37.62  E-value: 6.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194713878  13 TATSSYPLEPIAVDK---NFRG-----KPEHNPQQCIGCAACVNACPSNALTVETDlatNELAWQFNLsrCIFCGRCEEV 84
Cdd:PRK09623  18 KSVDEYPEAPISLGTtlsNFTGdwrtfMPVVDESKCVKCYICWKFCPEPAIYIKED---GYVAIDYDY--CKGCGICANE 92

                         90
                 ....*....|.
gi 194713878  85 CPTAAIKLSQE 95
Cdd:PRK09623  93 CPTKAITMVKE 103
DMSOR_beta_like cd16371
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 44-95 7.03e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319893 [Multi-domain]  Cd Length: 140  Bit Score: 37.93  E-value: 7.03e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 194713878  44 AACVNACPSNALTVETDLATnelawQFNLSRCIFCGRCEEVCPTAAIKLSQE 95
Cdd:cd16371   60 PACVKVCPTGAITKREDGIV-----VVDQDKCIGCGYCVWACPYGAPQYNPE 106
Fer4 pfam00037
4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to ...
 69-91 7.29e-04

4Fe-4S binding domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 459642 [Multi-domain]  Cd Length: 24  Bit Score: 35.69  E-value: 7.29e-04
                          10        20
                  ....*....|....*....|...
gi 194713878   69 QFNLSRCIFCGRCEEVCPTAAIK 91
Cdd:pfam00037   2 VIDEEKCIGCGACVEVCPVGAIT 24
NapF COG1145
Ferredoxin [Energy production and conversion];
43-92 9.50e-04

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 38.55  E-value: 9.50e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 194713878  43 CAACVNACPSNALTVETDLATNELAWQFNLSRCIFCGRCEEVCPTAAIKL 92
Cdd:COG1145  152 PVDALAISGGKKIEEELKIAIKKAKAVIDAEKCIGCGLCVKVCPTGAIRL 201
DMSOR_beta_like cd16374
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 36-98 9.70e-04

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319896 [Multi-domain]  Cd Length: 139  Bit Score: 37.64  E-value: 9.70e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 194713878  36 NPQQCIGCAACVNACPSNALTVETDLatnelawqFNLSRCIFCGR---------CEEVCPTAAIKLSQEYEL 98
Cdd:cd16374   71 DPDKCIGCGMCAMACPFGVPRFDPSL--------KVAVKCDLCIDrrregklpaCVEACPTGALKFGDIEEL 134
PRK10882 PRK10882
hydrogenase 2 operon protein HybA;
35-90 1.45e-03

hydrogenase 2 operon protein HybA;


Pssm-ID: 236786 [Multi-domain]  Cd Length: 328  Bit Score: 38.11  E-value: 1.45e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194713878  35 HNPQQCIGCAACVNACPSNALTVETDLATN-----ELAWQFNLSRCIFCGR--CEEVCPTAAI 90
Cdd:PRK10882 140 YDKDVCTGCRYCMVACPFNVPKYDYNNPFGaihkcELCNQKGVERLDKGGLpgCVEVCPTGAV 202
NuoI COG1143
Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy ...
 25-65 1.63e-03

Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440758 [Multi-domain]  Cd Length: 66  Bit Score: 35.49  E-value: 1.63e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 194713878  25 VDKNFRGKPEHNPQQCIGCAACVNACPSNALTVETDLATNE 65
Cdd:COG1143   22 EDGEPGKVYVIDPDKCIGCGLCVEVCPTGAISMTPFELAVE 62
PsrB cd10551
polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial ...
 35-90 1.64e-03

polysulfide reductase beta (PsrB) subunit; This family includes the beta subunit of bacterial polysulfide reductase (PsrABC), an integral membrane-bound enzyme responsible for quinone-coupled reduction of polysulfides, a process important in extreme environments such as deep-sea vents and hot springs. Polysulfide reductase contains three subunits: a catalytic subunit PsrA, an electron transfer PsrB subunit and the hydrophobic transmembrane PsrC subunit. PsrB belongs to the DMSO reductase superfamily that contains [4Fe-4S] clusters which transfer the electrons from the A subunit to the hydrophobic integral membrane C subunit via the B subunit. In Shewanella oneidensis, which has highly diverse anaerobic respiratory pathways, PsrABC is responsible for H2S generation as well as its regulation via respiration of sulfur species. PsrB transfers electrons from PsrC (serving as quinol oxidase) to the catalytic subunit PsrA for reduction of corresponding electron acceptors. It has been shown that T. thermophilus polysulfide reductase could be a key energy-conserving enzyme of the respiratory chain, using polysulfide as the terminal electron acceptor and pumping protons across the membrane.


Pssm-ID: 319873 [Multi-domain]  Cd Length: 185  Bit Score: 37.51  E-value: 1.64e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194713878  35 HNPQQCIGCAACVNACPSNALTV-ETDLATNELAWQFNL---SRCIFC------GR---CEEVCPTAAI 90
Cdd:cd10551   80 VDYDKCIGCRYCMAACPYGARYFnPEEPHEFGEVPVRPKgvvEKCTFCyhrldeGLlpaCVEACPTGAR 148
DsrA COG2221
Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion ...
 31-58 2.26e-03

Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Inorganic ion transport and metabolism];


Pssm-ID: 441823 [Multi-domain]  Cd Length: 69  Bit Score: 35.03  E-value: 2.26e-03
                         10        20
                 ....*....|....*....|....*...
gi 194713878  31 GKPEHNPQQCIGCAACVNACPSNALTVE 58
Cdd:COG2221   37 GKLVIDEEKCIGCGACIRVCPTGAIKGE 64
DMSOR_beta_like cd16372
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 36-91 2.34e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319894 [Multi-domain]  Cd Length: 125  Bit Score: 36.54  E-value: 2.34e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 194713878  36 NPQQCIGCAACVNACpSNALTVETD-----LATNELAWQFNLSRCIFCGRCEEVCPTAAIK 91
Cdd:cd16372    6 DPEKCIGCLQCEEAC-SKTFFKEEDrekscIRITETEGGYAINVCNQCGECIDVCPTGAIT 65
NapF_like cd10564
NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, ...
 33-58 2.80e-03

NapF, iron-sulfur subunit of periplasmic nitrate reductase; This family contains NapF protein, the iron-sulfur subunit of periplasmic nitrate reductase. The periplasmic nitrate reductase NapABC of Escherichia coli likely functions during anaerobic growth in low-nitrate environments; napF operon expression is activated by cyclic AMP receptor protein (Crp). NapF is a subfamily of the beta subunit of DMSO reductase (DMSOR) family. DMSOR family members have a large, periplasmic molybdenum-containing alpha subunit as well as a small beta FeS subunit, and may also have a small gamma subunit. The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319886 [Multi-domain]  Cd Length: 139  Bit Score: 36.45  E-value: 2.80e-03
                         10        20
                 ....*....|....*....|....*.
gi 194713878  33 PEHNPQQCIGCAACVNACPSNALTVE 58
Cdd:cd10564  112 PELDADACTGCGACVSVCPVGAITLT 137
DMSOR_beta_like cd16370
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 36-92 2.94e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319892 [Multi-domain]  Cd Length: 131  Bit Score: 36.10  E-value: 2.94e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 194713878  36 NPQQCIGCAACVNACPSNALTVETDLATNELawqfnlsrCIFCGRCEEVCPTAAIKL 92
Cdd:cd16370   81 DKEKCIGCGNCVKACIVGAIFWDEETNKPII--------CIHCGYCARYCPHDVLAM 129
PRK09898 PRK09898
ferredoxin-like protein;
37-86 3.25e-03

ferredoxin-like protein;


Pssm-ID: 182135 [Multi-domain]  Cd Length: 208  Bit Score: 36.74  E-value: 3.25e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 194713878  37 PQQCIGCA--ACVNACPSNALTVETDlatnELAWQFNLSRCIFCGRCEEVCP 86
Cdd:PRK09898 120 ADTCRQCKepQCMNVCPIGAITWQQK----EGCITVDHKRCIGCSACTTACP 167
PRK12385 PRK12385
succinate dehydrogenase/fumarate reductase iron-sulfur subunit;
39-102 3.69e-03

succinate dehydrogenase/fumarate reductase iron-sulfur subunit;


Pssm-ID: 183490 [Multi-domain]  Cd Length: 244  Bit Score: 36.99  E-value: 3.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194713878  39 QCIGCAACVNACPSNALTVE-TDLATNELAWQFNL-SR-------------------CIFCGRCEEVC-----PTAAIKL 92
Cdd:PRK12385 148 GCINCGLCYAACPQFGLNPEfIGPAAITLAHRYNLdSRdhgkkermkqlngqngvwsCTFVGYCSEVCpkhvdPAAAIQQ 227

                         90
                 ....*....|....*
gi 194713878  93 -----SQEYELAVWK 102
Cdd:PRK12385 228 gkvesAKDFLIAMLK 242
DMSOR_beta-like cd04410
Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta ...
 40-91 4.48e-03

Beta subunit of the DMSO Reductase (DMSOR) family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319870 [Multi-domain]  Cd Length: 136  Bit Score: 35.83  E-value: 4.48e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 194713878  40 CIGCAACVNACP-SNALTVETD------LATNELAWQFNLSRCIFCG--RCEEVCPTAAIK 91
Cdd:cd04410    8 CIGCGTCEVACKqEHGLRPGPDwsrikvIEGGGLERAFLPVSCMHCEdpPCVKACPTGAIY 68
Fer4_17 pfam13534
4Fe-4S dicluster domain; This family includes proteins containing domains which bind to ...
 40-86 4.49e-03

4Fe-4S dicluster domain; This family includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. The structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 433287 [Multi-domain]  Cd Length: 61  Bit Score: 34.36  E-value: 4.49e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 194713878   40 CIGCAACVNACPSNALT--------VETDLATNELAWQFNL-SRCIFCGRCEEVCP 86
Cdd:pfam13534   2 CIQCGCCVDECPRYLLNgdepkklmRAAYLGDLEELQANKVaNLCSECGLCEYACP 57
NapF COG1145
Ferredoxin [Energy production and conversion];
34-62 4.50e-03

Ferredoxin [Energy production and conversion];


Pssm-ID: 440760 [Multi-domain]  Cd Length: 238  Bit Score: 36.62  E-value: 4.50e-03
                         10        20
                 ....*....|....*....|....*....
gi 194713878  34 EHNPQQCIGCAACVNACPSNALTVETDLA 62
Cdd:COG1145  209 VVDPDKCIGCGACVKVCPVGAISLEPKEI 237
PorD COG1144
Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta ...
 24-58 4.86e-03

Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit [Energy production and conversion]; Pyruvate:ferredoxin oxidoreductase or related 2-oxoacid:ferredoxin oxidoreductase, delta subunit is part of the Pathway/BioSystem: Pyruvate oxidation


Pssm-ID: 440759 [Multi-domain]  Cd Length: 84  Bit Score: 34.64  E-value: 4.86e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 194713878  24 AVDKNFRGKPEHNPQQCIGCAACVNACPSNALTVE 58
Cdd:COG1144   46 AIRVDDGKYYGIDYDYCKGCGICAEVCPVKAIEMV 80
COG2768 COG2768
Uncharacterized Fe-S cluster protein [Function unknown];
30-62 5.20e-03

Uncharacterized Fe-S cluster protein [Function unknown];


Pssm-ID: 442050 [Multi-domain]  Cd Length: 74  Bit Score: 34.32  E-value: 5.20e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 194713878  30 RGKPEHNPQQCIGCAACVNACPSNALTVETDLA 62
Cdd:COG2768   32 DGKAVIDPEKCIGCGACIEVCPVGAIKIEWEED 64
ferrodoxin_EFR1 NF038196
EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight ...
 73-104 5.40e-03

EFR1 family ferrodoxin; Members of the family have a C-terminal ferrodoxin domain, with eight conserved Cys residues in two CxxCxxCxxxCP motifs, each of which binds a 4Fe-4S cluster. The N-terminal region resembles flavodoxin domains, with some members of the family recognized by Pfam models PF12724 (Flavodoxin_5) or PF00258 (Flavodoxin_1).


Pssm-ID: 468407 [Multi-domain]  Cd Length: 243  Bit Score: 36.38  E-value: 5.40e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 194713878  73 SRCIFCGRCEEVCPTAAIKLSQEYelAVWKKE 104
Cdd:NF038196 185 DKCIGCGICAKVCPVNNIEMEDGK--PVWGHN 214
Fer4_8 pfam13183
4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to ...
 39-86 5.55e-03

4Fe-4S dicluster domain; Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.


Pssm-ID: 433017 [Multi-domain]  Cd Length: 64  Bit Score: 34.21  E-value: 5.55e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 194713878   39 QCIGCAACVNACPSNALTVETD-------LATNELAWQFN------LSRCIFCGRCEEVCP 86
Cdd:pfam13183   1 RCIRCGACLAACPVYLVTGGRFpgdprggAAALLGRLEALeglaegLWLCTLCGACTEVCP 61
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
40-61 5.97e-03

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 36.54  E-value: 5.97e-03
                         10        20
                 ....*....|....*....|..
gi 194713878  40 CIGCAACVNACPSNALTVETDL 61
Cdd:COG4624  122 CISCGQCVAVCPFGAITEKSDI 143
FDH-O_like cd10560
beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes ...
 36-91 7.10e-03

beta subunit of formate dehydrogenase O (FDH-O) and similar proteins; This subfamily includes beta subunit of formate dehydrogenase family O (FDH-O), which is highly homologous to formate dehydrogenase N (FDH-N), a member of the DMSO reductase family. In E. coli three formate dehydrogenases are synthesized that are capable of oxidizing formate; Fdh-H, couples formate disproportionation to hydrogen and CO2, and is part of the cytoplasmically oriented formate hydrogenlyase complex, while FDH-N and FDH-O indicate their respective induction after growth with nitrate and oxygen. Little is known about FDH-O, although it shows formate oxidase activity during aerobic growth and is also synthesized during nitrate respiration, similar to FDH-N.


Pssm-ID: 319882 [Multi-domain]  Cd Length: 225  Bit Score: 35.82  E-value: 7.10e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194713878  36 NPQQCIGCAACVNACPSNalTVETDLATNeLAWqfnlsRCIFC---------GRCEEVCPTAAIK 91
Cdd:cd10560  106 QPDICNGCGYCVAACPFG--VIDRNEETG-RAH-----KCTLCydrlkdglePACAKACPTGSIQ 162
NapH COG0348
Polyferredoxin NapH [Energy production and conversion];
40-59 7.54e-03

Polyferredoxin NapH [Energy production and conversion];


Pssm-ID: 440117 [Multi-domain]  Cd Length: 263  Bit Score: 35.81  E-value: 7.54e-03
                         10        20
                 ....*....|....*....|
gi 194713878  40 CIGCAACVNACPSNALTVET 59
Cdd:COG0348  238 CINCGRCIDACPKDAIRFSS 257
CooF_like cd10563
CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the ...
 34-92 7.65e-03

CooF, iron-sulfur subunit of carbon monoxide dehydrogenase; This family includes CooF, the iron-sulfur subunit of carbon monoxide dehydrogenase (CODH), found in anaerobic bacteria and archaea. Carbon monoxide dehydrogenase is a key enzyme for carbon monoxide (CO) metabolism, where CooF is the proposed mediator of electron transfer between CODH and the CO-induced hydrogenase, catalyzing the reaction that uses CO as a single carbon and energy source, and producing only H2 and CO2. The ion-sulfur subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons in the protein complex during reaction.


Pssm-ID: 319885 [Multi-domain]  Cd Length: 140  Bit Score: 34.92  E-value: 7.65e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194713878  34 EHNPQQCIGCAACVNACPSNALT--VETDLAtnelawqfnlSRCIFCG-----RCEEVCPTAAIKL 92
Cdd:cd10563   84 IHDEEKCVGCWMCVMVCPYGAIRpdKERKVA----------LKCDLCPdretpACVEACPTGALVL 139
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 72-93 7.74e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 35.31  E-value: 7.74e-03
                         10        20
                 ....*....|....*....|..
gi 194713878  72 LSRCIFCGRCEEVCPTAAIKLS 93
Cdd:cd16373   13 LALCIRCGLCVEACPTGVIQPA 34
PRK10194 PRK10194
ferredoxin-type protein NapF;
32-62 8.40e-03

ferredoxin-type protein NapF;


Pssm-ID: 182296 [Multi-domain]  Cd Length: 163  Bit Score: 35.38  E-value: 8.40e-03
                         10        20        30
                 ....*....|....*....|....*....|.
gi 194713878  32 KPEHNPQQCIGCAACVNACPSNALTVETDLA 62
Cdd:PRK10194 132 QPQLNSQLCNGCGACAASCPVSAITAEYLHA 162
HybA_like cd10561
the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 ...
 35-91 8.88e-03

the FeS subunit of hydrogenase 2; This subfamily includes the beta-subunit of hydrogenase 2 (Hyd-2), an enzyme that catalyzes the reversible oxidation of H2 to protons and electrons. Hyd-2 is membrane-associated and forms an unusual heterotetrameric [NiFe]-hydrogenase in that it lacks the typical cytochrome b membrane anchor subunit that transfers electrons to the quinone pool. The electron transfer subunit of Hyd-2 (HybA) which is predicted to contain four iron-sulfur clusters, is essential for electron transfer from Hyd-2 to menaquinone/demethylmenaquinone (MQ/DMQ) to couple hydrogen oxidation to fumarate reduction.


Pssm-ID: 319883 [Multi-domain]  Cd Length: 196  Bit Score: 35.27  E-value: 8.88e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194713878  35 HNPQQCIGCAACVNACPSNALTVETDLATNElawqfnLSRCIFC------GR---CEEVCPTAAIK 91
Cdd:cd10561   96 YDEDKCIGCRYCMVACPFNIPKYEWDSANPK------IRKCTMCydrlkeGKqpaCVEACPTGALL 155
QueG COG1600
Epoxyqueuosine reductase QueG (queuosine biosynthesis) [Translation, ribosomal structure and ...
 34-86 9.31e-03

Epoxyqueuosine reductase QueG (queuosine biosynthesis) [Translation, ribosomal structure and biogenesis]; Epoxyqueuosine reductase QueG (queuosine biosynthesis) is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441208 [Multi-domain]  Cd Length: 345  Bit Score: 35.95  E-value: 9.31e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194713878  34 EHNPQQCIGCAACVNACPSNALTVEtdlatnelaWQFNLSRCI-----------------------F-CGRCEEVCP 86
Cdd:COG1600  180 EPVEDHCGSCTRCLDACPTGAIVAP---------YVLDARRCIsyltielkgpipeelrpkmgnriYgCDDCQDVCP 247
Fer4_6 pfam12837
4Fe-4S binding domain; This superfamily includes proteins containing domains which bind to ...
 32-55 9.42e-03

4Fe-4S binding domain; This superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.


Pssm-ID: 432822 [Multi-domain]  Cd Length: 24  Bit Score: 32.59  E-value: 9.42e-03
                          10        20
                  ....*....|....*....|....
gi 194713878   32 KPEHNPQQCIGCAACVNACPSNAL 55
Cdd:pfam12837   1 VVEVDPDKCIGCGRCVVVCPYGAI 24
DMSOR_beta_like cd16373
uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the ...
 19-52 9.66e-03

uncharacterized subfamily of DMSO Reductase beta subunit family; This family consists of the small beta iron-sulfur (FeS) subunit of the DMSO Reductase (DMSOR) family. Members of this family also contain a large, periplasmic molybdenum-containing alpha subunit and may have a small gamma subunit as well. Examples of heterodimeric members with alpha and beta subunits include arsenite oxidase, and tungsten-containing formate dehydrogenase (FDH-T) while heterotrimeric members containing alpha, beta, and gamma subunits include formate dehydrogenase-N (FDH-N), and nitrate reductase (NarGHI). The beta subunit contains four Fe4/S4 and/or Fe3/S4 clusters which transfer the electrons from the alpha subunit to a hydrophobic integral membrane protein, presumably a cytochrome containing two b-type heme groups. The reducing equivalents are then transferred to menaquinone, which finally reduces the electron-accepting enzyme system.


Pssm-ID: 319895 [Multi-domain]  Cd Length: 154  Bit Score: 34.92  E-value: 9.66e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 194713878  19 PLEPIAVDKNFR-GKPEHNPQQCIGCAACVNACPS 52
Cdd:cd16373  110 PTEAIAIVLEDDvLRPVVDEDKCVGCGLCEYVCPV 144
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH