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Conserved domains on  [gi|194474068|ref|NP_001124024|]
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lymphocyte antigen 6D precursor [Rattus norvegicus]

Protein Classification

Ly-6/uPAR domain-containing protein; Ly-6/uPAR domain-containing protein; acrosomal protein SP-10; acrosomal protein SP-10( domain architecture ID 10639047)

LU (Ly-6 antigen/uPA receptor-like) domain-containing protein similar to GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2); LU (Ly-6 antigen/uPA receptor-like) domain-containing protein similar to GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2); acrosomal protein SP-10 (ACRV1) is a testis-specific, intra-acrosomal protein that is associated with the membranes and matrix of the acrosomal vesicle; acrosomal protein SP-10 (ACRV1) is a testis-specific, intra-acrosomal protein that is associated with the membranes and matrix of the acrosomal vesicle

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_Ly6D cd23542
extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D ...
 16-96 1.03e-23

extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D (also called E48 antigen) is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion. It may act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Ly-6D contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467072  Cd Length: 79  Bit Score: 87.09  E-value: 1.03e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194474068  16 SPAQAFRCHVCISSDNCRNIQTCPPDFFYCRTITKVEPlKGNLVKKECAETCTISHSQQGHvSSGAEVTLCCDSDLCNDS 95
Cdd:cd23542    1 GPANALQCHVCNSSSNCTNPVNCEGSERYCKTTTVVQP-SGNLVKKGCAETCPPSTSRQQV-GSGISSVTCCQGDLCNSK 78


                 .
gi 194474068  96 L 96
Cdd:cd23542   79 L 79
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6D cd23542
extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D ...
 16-96 1.03e-23

extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D (also called E48 antigen) is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion. It may act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Ly-6D contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467072  Cd Length: 79  Bit Score: 87.09  E-value: 1.03e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194474068  16 SPAQAFRCHVCISSDNCRNIQTCPPDFFYCRTITKVEPlKGNLVKKECAETCTISHSQQGHvSSGAEVTLCCDSDLCNDS 95
Cdd:cd23542    1 GPANALQCHVCNSSSNCTNPVNCEGSERYCKTTTVVQP-SGNLVKKGCAETCPPSTSRQQV-GSGISSVTCCQGDLCNSK 78


                 .
gi 194474068  96 L 96
Cdd:cd23542   79 L 79
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 21-99 9.50e-09

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 49.07  E-value: 9.50e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194474068    21 FRCHVCISS--DNCRNIQTCPPDFFYCRTITKVEPLK--GNLVKKECA--ETCTISHSQQGHVSSGAEVTLCCDSDLCND 94
Cdd:smart00134   1 LQCYSCTGNpdSSCSSEEECRSPDDVCLTVVAEVISDsrGSVVYKGCAtsPICPGSHGYEINLTIAFLKVSCCQTDLCNA 80


                   ....*
gi 194474068    95 SLHNI 99
Cdd:smart00134  81 AGPGA 85
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 23-93 2.50e-07

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 44.84  E-value: 2.50e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194474068   23 CHVCI--SSDNCRNIQTCPPDFFYCRTITKVEP---LKGNLVKKECA-ETCTISHSQQGHVSSGAEVTLCCDSDLCN 93
Cdd:pfam00021   1 CYSCLgvSNEDCLSEVTCPLSDGQCVTTTLELPegnLRGTVVSKGCArSSCPRLLSDFINGGIISVSESCCQSDLCN 77
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6D cd23542
extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D ...
 16-96 1.03e-23

extracellular domain (ECD) found in lymphocyte antigen 6D (Ly-6D) and similar proteins; Ly-6D (also called E48 antigen) is a GPI-anchored molecule apparently involved in keratinocyte cell-cell adhesion. It may act as a specification marker at earliest stage specification of lymphocytes between B- and T-cell development. Ly-6D contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467072  Cd Length: 79  Bit Score: 87.09  E-value: 1.03e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194474068  16 SPAQAFRCHVCISSDNCRNIQTCPPDFFYCRTITKVEPlKGNLVKKECAETCTISHSQQGHvSSGAEVTLCCDSDLCNDS 95
Cdd:cd23542    1 GPANALQCHVCNSSSNCTNPVNCEGSERYCKTTTVVQP-SGNLVKKGCAETCPPSTSRQQV-GSGISSVTCCQGDLCNSK 78


                 .
gi 194474068  96 L 96
Cdd:cd23542   79 L 79
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 21-99 9.50e-09

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 49.07  E-value: 9.50e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194474068    21 FRCHVCISS--DNCRNIQTCPPDFFYCRTITKVEPLK--GNLVKKECA--ETCTISHSQQGHVSSGAEVTLCCDSDLCND 94
Cdd:smart00134   1 LQCYSCTGNpdSSCSSEEECRSPDDVCLTVVAEVISDsrGSVVYKGCAtsPICPGSHGYEINLTIAFLKVSCCQTDLCNA 80


                   ....*
gi 194474068    95 SLHNI 99
Cdd:smart00134  81 AGPGA 85
TFP_LU_ECD_Ly6M cd23552
extracellular domain (ECD) found in Mus musculus Ly-6 family protein Ly-6M and similar ...
 16-96 5.43e-08

extracellular domain (ECD) found in Mus musculus Ly-6 family protein Ly-6M and similar proteins; Ly-6M is a novel member of the Ly-6 family of hematopoietic proteins. It contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467082  Cd Length: 80  Bit Score: 46.78  E-value: 5.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194474068  16 SPAQAFRCHVCISSDNCRNIQTCPPDFFYCRTITKVEPLKGNLVKKECAETCTISHSqqghvSSGAEVTLCCDSDLCNDS 95
Cdd:cd23552    2 SSAQALKCHECKGIEDCYNPTSCNNQSRYCLTTWYTPPGEKTTVTKSCAYTCPDAPE-----SLANSKASCCNTDLCNSA 76


                 .
gi 194474068  96 L 96
Cdd:cd23552   77 V 77
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 23-93 2.50e-07

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 44.84  E-value: 2.50e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194474068   23 CHVCI--SSDNCRNIQTCPPDFFYCRTITKVEP---LKGNLVKKECA-ETCTISHSQQGHVSSGAEVTLCCDSDLCN 93
Cdd:pfam00021   1 CYSCLgvSNEDCLSEVTCPLSDGQCVTTTLELPegnLRGTVVSKGCArSSCPRLLSDFINGGIISVSESCCQSDLCN 77
TFP cd00117
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 22-93 1.79e-05

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


Pssm-ID: 467060  Cd Length: 81  Bit Score: 40.16  E-value: 1.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194474068  22 RCHVCISSDNCR------NIQTCPPDFFYCRTITKVEPLKGNLVKKECA--ETCTISHSQQGHVSSGAEVTLCCDSDLCN 93
Cdd:cd00117    2 KCYQCNSSNDPNccnsspTLVTCSSPETFCRKIVGKVGGGETLVIRGCAteCECGCTECCSGTGTSGTTCTSCCDTDLCN 81
TFP_LU_ECD_GPIHBP1 cd23575
extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density ...
 20-93 2.36e-05

extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPI-HBP1) and similar proteins; GPI-HBP1 (also called GPI-anchored HDL-binding protein 1, or high density lipoprotein-binding protein 1) is an endothelial cell transporter for lipoprotein lipase. It mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries and anchors LPL on the surface of endothelial cells in the lumen of blood capillaries. GPI-HBP1 protects LPL against loss of activity, and against ANGPTL4-mediated unfolding. Thereby, it plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis. GPI-HBP1 binds chylomicrons and phospholipid particles that contain APOA5. It also binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL. GPI-HBP1 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467105  Cd Length: 83  Bit Score: 40.01  E-value: 2.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194474068  20 AFRCHVCI---SSDNCRNIQTCPPDFFYCRTI---TKVEPLKGNLVKKECAETCTIShsqqGHVSSGAEVTL-CCDSDLC 92
Cdd:cd23575    2 SLKCYTCVsahSNSDCLTETNCSSSDTYCKTLvasASGGSGSLTTITKWCASSCTPS----TRTVEGTKVTVsCCQTDLC 77


                 .
gi 194474068  93 N 93
Cdd:cd23575   78 N 78
TFP_snake_toxin cd00206
Snake toxin domain; The snake toxin domain is present in short and long neurotoxins, ...
 23-93 2.29e-04

Snake toxin domain; The snake toxin domain is present in short and long neurotoxins, cytotoxins and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. This domain contains 60-75 amino acids that are fixed by 4-5 disulfide bridges and is nearly all beta sheets; it exists as either a monomer or a dimer. The snake toxin domain exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold), which also includes extracellular domain (ECD) found in Ly-6 antigen/uPA receptor-like (LU) superfamily.


Pssm-ID: 467061  Cd Length: 64  Bit Score: 36.94  E-value: 2.29e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 194474068  23 CHVCISSdNCRNIQTCPPDFFYCRTITKVEPLKGNLVKKECAETCTIshsqqghVSSGAEVTlCCDSDLCN 93
Cdd:cd00206    3 CYNCPSS-TCPTTKTCPPGENLCYKKWWRDGPRGKRIERGCAATCPK-------PKPGEKVK-CCSTDKCN 64
TFP_LU_ECD_Ly6E cd23543
extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E ...
 21-93 2.79e-04

extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E (also called retinoic acid-induced gene E protein (RIG-E), or stem cell antigen 2 (SCA-2), or thymic shared antigen 1 (TSA-1)) is a GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. It restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. It plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). It may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. Ly-6E contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467073  Cd Length: 78  Bit Score: 36.95  E-value: 2.79e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194474068  21 FRCHVCISSDNCRNIQTCPPDFFYCRTITKVEPLKGN---LVKKECAETCTISHSQQGHVSSGaevTLCCDSDLCN 93
Cdd:cd23543    6 YTCENQSSNWNCLKPTKCSDNDKYCVTTVASGGTGSSsgvRITKKCSPKCPETNVNIGIASVS---TSCCQSSLCN 78
TFP_LU_ECD_uPAR_rpt1 cd23556
first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor ...
 22-93 2.04e-03

first extracellular domain (ECD) found in urokinase plasminogen activator surface receptor (uPAR) and similar proteins; uPAR (also called U-PAR, or monocyte activation antigen Mo3, or CD87) acts as a receptor for urokinase plasminogen activator. It plays a role in localizing and promoting plasmin formation. It mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form. uPAR contains three extracellular domains (ECDs) that belong to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold). This model corresponds to the first ECD.


Pssm-ID: 467086  Cd Length: 79  Bit Score: 34.74  E-value: 2.04e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194474068  22 RCHVCISSDNCRNIQTCPPDFFYCRTI---TKVEPLKGNLVKKECAET----CTISHSQQGHVSSGAEVtlCCDSDLCN 93
Cdd:cd23556    2 RCYSCKSNGDCRVEEVCALGQDLCRTTvmtLWEEGEELELVVKGCDVSgktnASSSYRTGLNINSLQET--VCSSDLCN 78
TFP_LU_ECD_PSCA cd23573
extracellular domain (ECD) found in prostate stem cell antigen (PSCA) and similar proteins; ...
 19-93 3.54e-03

extracellular domain (ECD) found in prostate stem cell antigen (PSCA) and similar proteins; PSCA may be involved in the regulation of cell proliferation. It has a cell-proliferation inhibition activity in vitro. PSCA may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro it inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs. PSCA contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467103  Cd Length: 78  Bit Score: 33.96  E-value: 3.54e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194474068  19 QAFRCHVCISSDNCRNIQTCPPDFFYCRTITKVEPLKGNLVKKECAETCTISHsQQGHVssGAEVTLCCDSDLCN 93
Cdd:cd23573    4 QCYTCKAQLSNSNCQTETPCRENAKACKTDVIRAVGLLKVISKECSSSCTEDY-QDYFV--GKRNITCCSTDLCN 75
TFP_LU_ECD_LYNX1 cd23585
extracellular domain (ECD) found in Ly-6/neurotoxin-like protein 1 (LYNX1) and similar protein; ...
 20-93 3.78e-03

extracellular domain (ECD) found in Ly-6/neurotoxin-like protein 1 (LYNX1) and similar protein; LYNX1 (also called testicular tissue protein Li 112) is an endogenous prototoxin that acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs). It prevents plasticity in the primary visual cortex late in life. LYNX1 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467115  Cd Length: 74  Bit Score: 33.82  E-value: 3.78e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194474068  20 AFRCHVCI-SSDNCRNIQTCPPDFFYCRTITKVEPLKGNLVKKECAETC--TISHSQQGHVSSgaevTLCCDSDLCN 93
Cdd:cd23585    1 ALDCHVCAyNGDNCFNPMRCPAMVAYCMTTRTYYTPTRMKVSKSCVPRCfeTVYDGYSKHAST----TSCCQYDLCN 73
Toxin_TOLIP pfam00087
Snake toxin and toxin-like protein; This family predominantly includes venomous neurotoxins ...
 22-93 7.85e-03

Snake toxin and toxin-like protein; This family predominantly includes venomous neurotoxins and cytotoxins from snakes, but also structurally similar (non-snake) toxin-like proteins (TOLIPs) such as Lymphocyte antigen 6D and Ly6/PLAUR domain-containing protein. Snake toxins are short proteins with a compact, disulphide-rich structure. TOLIPs have similar structural features (abundance of spaced cysteine residues, a high frequency of charge residues, a signal peptide for secretion and a compact structure) but, are not associated with a venom gland or poisonous function. They are endogenous animal proteins that are not restricted to poisonous animals.


Pssm-ID: 395040  Cd Length: 70  Bit Score: 32.97  E-value: 7.85e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 194474068   22 RCHVCISSDNCRNIQTCPPDFFYCRTITKVEPLKGNLVKKECAETCTISHSQQGHVSSGAEvtlCCDSDLCN 93
Cdd:pfam00087   2 RCHNCAAAGNCVQPETCQDNTRYCLTLWNSPPGHRTHVIKGCAYTCPVTQESLNISRASDC---CCETDLCN 70
TFP_LU_ECD_GML cd23555
extracellular domain (ECD) found in glycosyl-phosphatidylinositol-anchored molecule-like ...
 21-93 8.21e-03

extracellular domain (ECD) found in glycosyl-phosphatidylinositol-anchored molecule-like protein (GML) and similar proteins; GML may play a role in the apoptotic pathway or cell-cycle regulation induced by p53/TP53 after DNA damage. It contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467085  Cd Length: 87  Bit Score: 33.12  E-value: 8.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194474068  21 FRCHVCISSD--NCRNIQTCPPDFFYCRTITKVEPLKGNLVKKECAETCT-ISHSQQ----GHVSSGAEV---TLCCDSD 90
Cdd:cd23555    1 LRCHSCAVINtfNCPAHRTCPYDIRRCMTVAIRVNSRELLVYKNCTKNCTfVYAEEQppeaPRKIPKTNSfyfVMCCSSM 80


                 ...
gi 194474068  91 LCN 93
Cdd:cd23555   81 FCN 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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