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Conserved domains on  [gi|194390088|dbj|BAG60560|]
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unnamed protein product [Homo sapiens]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
24-176 1.37e-66

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 204.50  E-value: 1.37e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194390088   24 HPNLLLLPPSFWENNCKFLYVARNAKDCMVSYYHFQRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGWWEMKDRHQ 103
Cdd:pfam00685  78 HLPLHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGN 157

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194390088  104 ILFLFYEDIKRDPKHEIRKVMQFMGKKVDETVLDKIVQETSFEKMKENPMTNRSTvsksiLDQSISSFMRKGV 176
Cdd:pfam00685 158 ILFLRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSK-----LPKEVSPFFRKGL 225
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
24-176 1.37e-66

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 204.50  E-value: 1.37e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194390088   24 HPNLLLLPPSFWENNCKFLYVARNAKDCMVSYYHFQRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGWWEMKDRHQ 103
Cdd:pfam00685  78 HLPLHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGN 157

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194390088  104 ILFLFYEDIKRDPKHEIRKVMQFMGKKVDETVLDKIVQETSFEKMKENPMTNRSTvsksiLDQSISSFMRKGV 176
Cdd:pfam00685 158 ILFLRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSK-----LPKEVSPFFRKGL 225
PLN02164 PLN02164
sulfotransferase
 29-149 1.13e-16

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 76.50  E-value: 1.13e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194390088  29 LLPPSFWENNCKFLYVARNAKDCMVSYYHF-QRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGWWE--MKDRHQIL 105
Cdd:PLN02164 156 LLPDSVVKSGCKMVYIWRDPKDTFISMWTFlHKERSQQGPLNSLEESFDMFCRGLSVYGPYLDHVLGYWKayQENPDRIL 235

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 194390088 106 FLFYEDIKRDPKHEIRKVMQFMG-----KKVDETVLDKIVQETSFEKMK 149
Cdd:PLN02164 236 FLKYETMRADPLPYVKRLAEFMGygftaEEEEKGVVEKVVKLCSFETLK 284
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
24-176 1.37e-66

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 204.50  E-value: 1.37e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194390088   24 HPNLLLLPPSFWENNCKFLYVARNAKDCMVSYYHFQRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGWWEMKDRHQ 103
Cdd:pfam00685  78 HLPLHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGN 157

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194390088  104 ILFLFYEDIKRDPKHEIRKVMQFMGKKVDETVLDKIVQETSFEKMKENPMTNRSTvsksiLDQSISSFMRKGV 176
Cdd:pfam00685 158 ILFLRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSK-----LPKEVSPFFRKGL 225
PLN02164 PLN02164
sulfotransferase
 29-149 1.13e-16

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 76.50  E-value: 1.13e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194390088  29 LLPPSFWENNCKFLYVARNAKDCMVSYYHF-QRMNHMLPDPGTWEEYFETFINGKVVWGSWFDHVKGWWE--MKDRHQIL 105
Cdd:PLN02164 156 LLPDSVVKSGCKMVYIWRDPKDTFISMWTFlHKERSQQGPLNSLEESFDMFCRGLSVYGPYLDHVLGYWKayQENPDRIL 235

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 194390088 106 FLFYEDIKRDPKHEIRKVMQFMG-----KKVDETVLDKIVQETSFEKMK 149
Cdd:PLN02164 236 FLKYETMRADPLPYVKRLAEFMGygftaEEEEKGVVEKVVKLCSFETLK 284
Sulfotransfer_3 pfam13469
Sulfotransferase family;
40-128 2.53e-04

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 39.97  E-value: 2.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194390088   40 KFLYVARNAKDCMVSyyhfQRMNHMLPDPGTWEEYFETFINGKVVWgsWFDHVKGWWEMKDRH---QILFLFYEDIKRDP 116
Cdd:pfam13469  83 KFIHLHRDPVDTVIS----SYCSLFGFTLSSYSTAFLRDIGLALAR--WSRAYERLMAARARVppgRFLDVRYEDLVADP 156

                          90
                  ....*....|..
gi 194390088  117 KHEIRKVMQFMG 128
Cdd:pfam13469 157 EGTLRRILEFLG 168
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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