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Conserved domains on  [gi|194387700|dbj|BAG61263|]
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unnamed protein product [Homo sapiens]

Protein Classification

bifunctional NTP pyrophosphatase/methyltransferase( domain architecture ID 10833645)

bifunctional nucleoside triphosphate (NTP) pyrophosphatase/methyltransferase, such as human probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein that contains an N-terminal nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP and a C-terminal class I SAM-dependent methyltransferase that may catalyze the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  3.90.950.10|2.20.25.110
EC:  3.6.1.9|2.1.1.-
Gene Ontology:  GO:0047429|GO:0009146|GO:0000166|GO:1904047|GO:0008168
PubMed:  12826405|12504684
SCOP:  4000518|3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Maf cd00555
Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in ...
 15-198 3.10e-70

Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or nucleic acid-binding protein with structural similarity to the hypoxanthine/xanthine NTP pyrophosphatase Ham1 from Methanococcus jannaschii, RNase H from Escherichia coli, and some other nucleotide or RNA-binding proteins.


:

Pssm-ID: 238310  Cd Length: 180  Bit Score: 224.66  E-value: 3.10e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  15 VVLAS----------NAGLRFEVVPSKFKEKLDKASfaTPYGYAMETAKQKALEVANRLyqkdlRAPDVVIGADTIVTVG 84
Cdd:cd00555    1 LILASasprrrelleQLGIPFEVVPSDIDETPIKGE--SPEDYVLRLAEAKAEAVAARL-----PPDALVIGADTVVVLD 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  85 GLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHCsskdhqlDTRVSEFYEETKVKFSELSEELLWEYVHSGEPMDKAG 164
Cdd:cd00555   74 GRILGKPKDREEAREMLKRLSGRTHEVYTGVALIDP-------GGKLVTDVESTKVRFRELSDEEIEAYVASGEPLDKAG 146

                        170       180       190
                 ....*....|....*....|....*....|....
gi 194387700 165 GYGIQALGGMLVESVHGDFLNVVGFPLNHFCKQL 198
Cdd:cd00555  147 AYGIQGLGGALIERIEGDYSNVVGLPLPELLKLL 180
AdoMet_MTases super family cl17173
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 378-589 1.73e-61

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


The actual alignment was detected with superfamily member pfam00891:

Pssm-ID: 473071 [Multi-domain]  Cd Length: 208  Bit Score: 202.64  E-value: 1.73e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  378 FTYLEFAIREGTNQHHRALGKKAedlfQDAYYQSPETRLRFMRAMHGMTKLTACQVATAFNLSRFSSACDVGGCTGALAR 457
Cdd:pfam00891   1 WRYLADAVREGRNQYNKAFGISL----FEAIYRDEEERLLFNRGLQEHWSLIGKDVLTAFDLSGFRSLVDVGGGTGALAQ 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  458 ELAREYPRMQVTVFDLPDIIELA-AHFQPPGPQAVQIHfaAGDFFRDPLPSAELYVLCRILHDWPDDKVHKLLSKVAESC 536
Cdd:pfam00891  77 AIVSLYPGCKGIVFDLPHVVEAApTHFSAGEEPRVTFH--GGDFFKDSLPEADAYILKRVLHDWSDEKCVKLLKRCYKAC 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 194387700  537 KPGAGLLLVETLLDEEKRVAQRALMQSLNMLVQTEGKERSLGEYQCLLELHGF 589
Cdd:pfam00891 155 PAGGKVILVESLLGADPSGPLHTQLYSLNMLAQTEGRERTEAEYSELLTGAGF 207
dimerization2 pfam16864
dimerization domain; This domain, found in methyltransferases, functions as a dimerization ...
 278-361 2.17e-32

dimerization domain; This domain, found in methyltransferases, functions as a dimerization domain.


:

Pssm-ID: 465287  Cd Length: 87  Bit Score: 119.59  E-value: 2.17e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  278 LLELIEGFMLSKGLLTACKLKVFDLLKdEAPQKAADIASKVDASACGMERLLDICAAMGLLEKTEQ----GYSNTETANV 353
Cdd:pfam16864   1 LLDLIDGFRASKVLFTACELGVFDLLA-EGPLSAEEVAARLGASVDGTERLLDACVALGLLEREKTdgkgLYSNTELAST 79


                  ....*...
gi 194387700  354 YLASDGEY 361
Cdd:pfam16864  80 YLVSSSPK 87
 
Name Accession Description Interval E-value
Maf cd00555
Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in ...
 15-198 3.10e-70

Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or nucleic acid-binding protein with structural similarity to the hypoxanthine/xanthine NTP pyrophosphatase Ham1 from Methanococcus jannaschii, RNase H from Escherichia coli, and some other nucleotide or RNA-binding proteins.


Pssm-ID: 238310  Cd Length: 180  Bit Score: 224.66  E-value: 3.10e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  15 VVLAS----------NAGLRFEVVPSKFKEKLDKASfaTPYGYAMETAKQKALEVANRLyqkdlRAPDVVIGADTIVTVG 84
Cdd:cd00555    1 LILASasprrrelleQLGIPFEVVPSDIDETPIKGE--SPEDYVLRLAEAKAEAVAARL-----PPDALVIGADTVVVLD 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  85 GLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHCsskdhqlDTRVSEFYEETKVKFSELSEELLWEYVHSGEPMDKAG 164
Cdd:cd00555   74 GRILGKPKDREEAREMLKRLSGRTHEVYTGVALIDP-------GGKLVTDVESTKVRFRELSDEEIEAYVASGEPLDKAG 146

                        170       180       190
                 ....*....|....*....|....*....|....
gi 194387700 165 GYGIQALGGMLVESVHGDFLNVVGFPLNHFCKQL 198
Cdd:cd00555  147 AYGIQGLGGALIERIEGDYSNVVGLPLPELLKLL 180
Maf pfam02545
Maf-like protein; Maf is a putative inhibitor of septum formation in eukaryotes, bacteria, and ...
 15-201 1.36e-61

Maf-like protein; Maf is a putative inhibitor of septum formation in eukaryotes, bacteria, and archaea.


Pssm-ID: 460586  Cd Length: 174  Bit Score: 201.86  E-value: 1.36e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700   15 VVLAS----------NAGLRFEVVPSKFKEKLDKASfATPYGYAMETAKQKALevanrlyqkdlrapDVVIGADTIVTvg 84
Cdd:pfam02545   1 LILASasprrrelleQLGIEFEVVPSDIDETPLKED-PAPEEYVLRLARAKAE--------------ALVIGADTVVV-- 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700   85 gLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHCSSKDHQldtrvSEFYEETKVKFSELSEELLWEYVHSGEPMDKAG 164
Cdd:pfam02545  64 -LILGKPKDEEEARAMLKRLSGRTHEVYTGVALINPGGGTGG-----VSFVETTRVTFRPLSDEEIEAYVATGEPLDKAG 137

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 194387700  165 GYGIQALGGMLVESVHGDFLNVVGFPLNHFCKQLVKL 201
Cdd:pfam02545 138 AYGIQGLGAALVERIEGDYSNVVGLPLIELLRLLREL 174
Methyltransf_2 pfam00891
O-methyltransferase domain; This family includes a range of O-methyltransferases. These ...
 378-589 1.73e-61

O-methyltransferase domain; This family includes a range of O-methyltransferases. These enzymes utilize S-adenosyl methionine.


Pssm-ID: 395719 [Multi-domain]  Cd Length: 208  Bit Score: 202.64  E-value: 1.73e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  378 FTYLEFAIREGTNQHHRALGKKAedlfQDAYYQSPETRLRFMRAMHGMTKLTACQVATAFNLSRFSSACDVGGCTGALAR 457
Cdd:pfam00891   1 WRYLADAVREGRNQYNKAFGISL----FEAIYRDEEERLLFNRGLQEHWSLIGKDVLTAFDLSGFRSLVDVGGGTGALAQ 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  458 ELAREYPRMQVTVFDLPDIIELA-AHFQPPGPQAVQIHfaAGDFFRDPLPSAELYVLCRILHDWPDDKVHKLLSKVAESC 536
Cdd:pfam00891  77 AIVSLYPGCKGIVFDLPHVVEAApTHFSAGEEPRVTFH--GGDFFKDSLPEADAYILKRVLHDWSDEKCVKLLKRCYKAC 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 194387700  537 KPGAGLLLVETLLDEEKRVAQRALMQSLNMLVQTEGKERSLGEYQCLLELHGF 589
Cdd:pfam00891 155 PAGGKVILVESLLGADPSGPLHTQLYSLNMLAQTEGRERTEAEYSELLTGAGF 207
Maf COG0424
7-methyl-GTP pyrophosphatase and related NTP pyrophosphatases, Maf/HAM1 superfamily [Secondary ...
 13-191 3.08e-61

7-methyl-GTP pyrophosphatase and related NTP pyrophosphatases, Maf/HAM1 superfamily [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440193  Cd Length: 189  Bit Score: 201.42  E-value: 3.08e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  13 KRVVLAS----------NAGLRFEVVPSKFKEKLDKAsfATPYGYAMETAKQKALEVANRLyqkdlrAPDVVIGADTIVT 82
Cdd:COG0424    1 PKLILASasprrrelleQLGLPFEVVPPDIDETPLPG--ESPEELVLRLARAKAEAVAARL------PDALVLGADTVVV 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  83 VGGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHcsskdhqLDTRVSEFYEETKVKFSELSEELLWEYVHSGEPMDK 162
Cdd:COG0424   73 LDGRILGKPADAEEARAMLRRLSGRTHRVHTGVALID-------PGGRLWTRVVTTRVTFRPLSDAEIEAYLATGEPLDK 145

                        170       180
                 ....*....|....*....|....*....
gi 194387700 163 AGGYGIQALGGMLVESVHGDFLNVVGFPL 191
Cdd:COG0424  146 AGAYGIQGLGAALVERIEGSYSNVVGLPL 174
PRK00648 PRK00648
Maf-like protein; Reviewed
 13-201 1.04e-54

Maf-like protein; Reviewed


Pssm-ID: 234807  Cd Length: 191  Bit Score: 184.34  E-value: 1.04e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  13 KRVVLASNA----------GLRFEVVPSKFKEKlDKASFATPYGYAMETAKQKALEVANRLYQKDLrapdvVIGADTIVT 82
Cdd:PRK00648   3 YKIILASSSprrkeilegfRIPFEVVPSPFVEE-SYPYSLDPEEITLELARLKAEAVRSDLFPDEL-----IITADTIVW 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  83 VGGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHcsskdhqlDTRVSEFYEETKVKFSELSEELLWEYVHSGEPMDK 162
Cdd:PRK00648  77 YDGKVLGKPKDEEEAVEMLRTLSGKTHEVITGVCLLH--------NGKLLSGSETTQVTFRELSDEEIEYYIDTYKPLDK 148

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 194387700 163 AGGYGIQALGGMLVESVHGDFLNVVGFPLNHFCKQLVKL 201
Cdd:PRK00648 149 AGAYGIQEWGGLIVKKIEGSYYNVMGLPIQTLYEELKEL 187
maf TIGR00172
MAF protein; This nonessential gene causes inhibition of septation when overexpressed. A ...
 14-198 1.67e-43

MAF protein; This nonessential gene causes inhibition of septation when overexpressed. A member of the family is found in the Archaeon Pyrococcus horikoshii and another in the round worm Caenorhabditis elegans. [Cellular processes, Cell division]


Pssm-ID: 129276  Cd Length: 183  Bit Score: 153.71  E-value: 1.67e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700   14 RVVLASNAGLRFEVVPSKFKEKLDKASfaTPYGYAMETAKQKALEVANRLyqkdlraPD-VVIGADTIVTVGGLILEKPV 92
Cdd:TIGR00172  14 RKELLEELGISFEQIVSEFDEKSLKTT--SPRELVYRLAKEKAQAVAELL-------ADaLIIGADTVVILDGEIYGKPK 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700   93 DKQDAYRMLSRLSGREHSVFTGVAIVhcsSKDHQLDtrvseFYEETKVKFSELSEELLWEYVHSGEPMDKAGGYGIQALG 172
Cdd:TIGR00172  85 DKEEAAEFLRKLSGQEHEVYTAVALI---DSVHLLT-----FLDVTKVHFRALDPEEIEKYVESGEPLEKAGAFGIEGFG 156

                         170       180
                  ....*....|....*....|....*.
gi 194387700  173 GMLVESVHGDFLNVVGFPLNHFCKQL 198
Cdd:TIGR00172 157 APLIKKIDGDYSNVVGLPLEKLLGAL 182
dimerization2 pfam16864
dimerization domain; This domain, found in methyltransferases, functions as a dimerization ...
 278-361 2.17e-32

dimerization domain; This domain, found in methyltransferases, functions as a dimerization domain.


Pssm-ID: 465287  Cd Length: 87  Bit Score: 119.59  E-value: 2.17e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  278 LLELIEGFMLSKGLLTACKLKVFDLLKdEAPQKAADIASKVDASACGMERLLDICAAMGLLEKTEQ----GYSNTETANV 353
Cdd:pfam16864   1 LLDLIDGFRASKVLFTACELGVFDLLA-EGPLSAEEVAARLGASVDGTERLLDACVALGLLEREKTdgkgLYSNTELAST 79


                  ....*...
gi 194387700  354 YLASDGEY 361
Cdd:pfam16864  80 YLVSSSPK 87
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 430-562 2.15e-06

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 48.76  E-value: 2.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700 430 ACQVATAFNLSRFSSACDVGgC-TGALARELAREYpRMQVTVFDL-PDIIELAAHFQPPGPQAvQIHFAAGDFFRD---P 504
Cdd:COG0500   15 AALLALLERLPKGGRVLDLG-CgTGRNLLALAARF-GGRVIGIDLsPEAIALARARAAKAGLG-NVEFLVADLAELdplP 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 194387700 505 LPSAELYVLCRILHDWPDDKVHKLLSKVAESCKPGAGLLLVETLLDEEKRVAQRALMQ 562
Cdd:COG0500   92 AESFDLVVAFGVLHHLPPEEREALLRELARALKPGGVLLLSASDAAAALSLARLLLLA 149
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 447-549 2.10e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 38.18  E-value: 2.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700 447 DVGGCTGALARELAREYPRmQVTVFDL-PDIIELAAHFQPpGPQAVQIHFAAGDFFRDPLPSAELY--VLCRILHDWPDD 523
Cdd:cd02440    4 DLGCGTGALALALASGPGA-RVTGVDIsPVALELARKAAA-ALLADNVEVLKGDAEELPPEADESFdvIISDPPLHHLVE 81

                         90       100
                 ....*....|....*....|....*.
gi 194387700 524 KVHKLLSKVAESCKPGaGLLLVETLL 549
Cdd:cd02440   82 DLARFLEEARRLLKPG-GVLVLTLVL 106
 
Name Accession Description Interval E-value
Maf cd00555
Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in ...
 15-198 3.10e-70

Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or nucleic acid-binding protein with structural similarity to the hypoxanthine/xanthine NTP pyrophosphatase Ham1 from Methanococcus jannaschii, RNase H from Escherichia coli, and some other nucleotide or RNA-binding proteins.


Pssm-ID: 238310  Cd Length: 180  Bit Score: 224.66  E-value: 3.10e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  15 VVLAS----------NAGLRFEVVPSKFKEKLDKASfaTPYGYAMETAKQKALEVANRLyqkdlRAPDVVIGADTIVTVG 84
Cdd:cd00555    1 LILASasprrrelleQLGIPFEVVPSDIDETPIKGE--SPEDYVLRLAEAKAEAVAARL-----PPDALVIGADTVVVLD 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  85 GLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHCsskdhqlDTRVSEFYEETKVKFSELSEELLWEYVHSGEPMDKAG 164
Cdd:cd00555   74 GRILGKPKDREEAREMLKRLSGRTHEVYTGVALIDP-------GGKLVTDVESTKVRFRELSDEEIEAYVASGEPLDKAG 146

                        170       180       190
                 ....*....|....*....|....*....|....
gi 194387700 165 GYGIQALGGMLVESVHGDFLNVVGFPLNHFCKQL 198
Cdd:cd00555  147 AYGIQGLGGALIERIEGDYSNVVGLPLPELLKLL 180
Maf pfam02545
Maf-like protein; Maf is a putative inhibitor of septum formation in eukaryotes, bacteria, and ...
 15-201 1.36e-61

Maf-like protein; Maf is a putative inhibitor of septum formation in eukaryotes, bacteria, and archaea.


Pssm-ID: 460586  Cd Length: 174  Bit Score: 201.86  E-value: 1.36e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700   15 VVLAS----------NAGLRFEVVPSKFKEKLDKASfATPYGYAMETAKQKALevanrlyqkdlrapDVVIGADTIVTvg 84
Cdd:pfam02545   1 LILASasprrrelleQLGIEFEVVPSDIDETPLKED-PAPEEYVLRLARAKAE--------------ALVIGADTVVV-- 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700   85 gLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHCSSKDHQldtrvSEFYEETKVKFSELSEELLWEYVHSGEPMDKAG 164
Cdd:pfam02545  64 -LILGKPKDEEEARAMLKRLSGRTHEVYTGVALINPGGGTGG-----VSFVETTRVTFRPLSDEEIEAYVATGEPLDKAG 137

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 194387700  165 GYGIQALGGMLVESVHGDFLNVVGFPLNHFCKQLVKL 201
Cdd:pfam02545 138 AYGIQGLGAALVERIEGDYSNVVGLPLIELLRLLREL 174
Methyltransf_2 pfam00891
O-methyltransferase domain; This family includes a range of O-methyltransferases. These ...
 378-589 1.73e-61

O-methyltransferase domain; This family includes a range of O-methyltransferases. These enzymes utilize S-adenosyl methionine.


Pssm-ID: 395719 [Multi-domain]  Cd Length: 208  Bit Score: 202.64  E-value: 1.73e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  378 FTYLEFAIREGTNQHHRALGKKAedlfQDAYYQSPETRLRFMRAMHGMTKLTACQVATAFNLSRFSSACDVGGCTGALAR 457
Cdd:pfam00891   1 WRYLADAVREGRNQYNKAFGISL----FEAIYRDEEERLLFNRGLQEHWSLIGKDVLTAFDLSGFRSLVDVGGGTGALAQ 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  458 ELAREYPRMQVTVFDLPDIIELA-AHFQPPGPQAVQIHfaAGDFFRDPLPSAELYVLCRILHDWPDDKVHKLLSKVAESC 536
Cdd:pfam00891  77 AIVSLYPGCKGIVFDLPHVVEAApTHFSAGEEPRVTFH--GGDFFKDSLPEADAYILKRVLHDWSDEKCVKLLKRCYKAC 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 194387700  537 KPGAGLLLVETLLDEEKRVAQRALMQSLNMLVQTEGKERSLGEYQCLLELHGF 589
Cdd:pfam00891 155 PAGGKVILVESLLGADPSGPLHTQLYSLNMLAQTEGRERTEAEYSELLTGAGF 207
Maf COG0424
7-methyl-GTP pyrophosphatase and related NTP pyrophosphatases, Maf/HAM1 superfamily [Secondary ...
 13-191 3.08e-61

7-methyl-GTP pyrophosphatase and related NTP pyrophosphatases, Maf/HAM1 superfamily [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440193  Cd Length: 189  Bit Score: 201.42  E-value: 3.08e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  13 KRVVLAS----------NAGLRFEVVPSKFKEKLDKAsfATPYGYAMETAKQKALEVANRLyqkdlrAPDVVIGADTIVT 82
Cdd:COG0424    1 PKLILASasprrrelleQLGLPFEVVPPDIDETPLPG--ESPEELVLRLARAKAEAVAARL------PDALVLGADTVVV 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  83 VGGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHcsskdhqLDTRVSEFYEETKVKFSELSEELLWEYVHSGEPMDK 162
Cdd:COG0424   73 LDGRILGKPADAEEARAMLRRLSGRTHRVHTGVALID-------PGGRLWTRVVTTRVTFRPLSDAEIEAYLATGEPLDK 145

                        170       180
                 ....*....|....*....|....*....
gi 194387700 163 AGGYGIQALGGMLVESVHGDFLNVVGFPL 191
Cdd:COG0424  146 AGAYGIQGLGAALVERIEGSYSNVVGLPL 174
PRK00648 PRK00648
Maf-like protein; Reviewed
 13-201 1.04e-54

Maf-like protein; Reviewed


Pssm-ID: 234807  Cd Length: 191  Bit Score: 184.34  E-value: 1.04e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  13 KRVVLASNA----------GLRFEVVPSKFKEKlDKASFATPYGYAMETAKQKALEVANRLYQKDLrapdvVIGADTIVT 82
Cdd:PRK00648   3 YKIILASSSprrkeilegfRIPFEVVPSPFVEE-SYPYSLDPEEITLELARLKAEAVRSDLFPDEL-----IITADTIVW 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  83 VGGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHcsskdhqlDTRVSEFYEETKVKFSELSEELLWEYVHSGEPMDK 162
Cdd:PRK00648  77 YDGKVLGKPKDEEEAVEMLRTLSGKTHEVITGVCLLH--------NGKLLSGSETTQVTFRELSDEEIEYYIDTYKPLDK 148

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 194387700 163 AGGYGIQALGGMLVESVHGDFLNVVGFPLNHFCKQLVKL 201
Cdd:PRK00648 149 AGAYGIQEWGGLIVKKIEGSYYNVMGLPIQTLYEELKEL 187
PRK00078 PRK00078
Maf-like protein; Reviewed
 13-202 6.54e-52

Maf-like protein; Reviewed


Pssm-ID: 234618  Cd Length: 192  Bit Score: 176.84  E-value: 6.54e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  13 KRVVLASNAGLR----------FEVVPSKFKEklDKASFATPYG-YAMETAKQKALEVANRLYQKDlrapDVVIGADTIV 81
Cdd:PRK00078   1 MKIILASASERRqellkriledFQVIVSDFDE--SSVPFKGNIEsYVMNLAEGKARSVSKKLDQES----SIVIGCDTIV 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  82 TVGGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVhcsskDHQLDTRVSEFyEETKVKFSELSEELLWEYVHSGEPMD 161
Cdd:PRK00078  75 AFNGKVLGKPKDEEDAFEMLKALSGNEHEVYSGIAIL-----DTKSNKIIKDF-VCTEVKFSKLTDRQIRKYINTGEPMD 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 194387700 162 KAGGYGIQALGGMLVESVHGDFLNVVGFPLNhfckqlvKLY 202
Cdd:PRK00078 149 KAGAYGIQGKGGVFVEEINGCYYNVVGLPLN-------KLY 182
maf TIGR00172
MAF protein; This nonessential gene causes inhibition of septation when overexpressed. A ...
 14-198 1.67e-43

MAF protein; This nonessential gene causes inhibition of septation when overexpressed. A member of the family is found in the Archaeon Pyrococcus horikoshii and another in the round worm Caenorhabditis elegans. [Cellular processes, Cell division]


Pssm-ID: 129276  Cd Length: 183  Bit Score: 153.71  E-value: 1.67e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700   14 RVVLASNAGLRFEVVPSKFKEKLDKASfaTPYGYAMETAKQKALEVANRLyqkdlraPD-VVIGADTIVTVGGLILEKPV 92
Cdd:TIGR00172  14 RKELLEELGISFEQIVSEFDEKSLKTT--SPRELVYRLAKEKAQAVAELL-------ADaLIIGADTVVILDGEIYGKPK 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700   93 DKQDAYRMLSRLSGREHSVFTGVAIVhcsSKDHQLDtrvseFYEETKVKFSELSEELLWEYVHSGEPMDKAGGYGIQALG 172
Cdd:TIGR00172  85 DKEEAAEFLRKLSGQEHEVYTAVALI---DSVHLLT-----FLDVTKVHFRALDPEEIEKYVESGEPLEKAGAFGIEGFG 156

                         170       180
                  ....*....|....*....|....*.
gi 194387700  173 GMLVESVHGDFLNVVGFPLNHFCKQL 198
Cdd:TIGR00172 157 APLIKKIDGDYSNVVGLPLEKLLGAL 182
PRK14363 PRK14363
Maf-like protein; Provisional
 14-191 2.07e-38

Maf-like protein; Provisional


Pssm-ID: 184647  Cd Length: 204  Bit Score: 140.80  E-value: 2.07e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  14 RVVLASNA----------GLRFEVVPSKFKEKLdkasfatpYGYAMETAKQKALEVANRLYQKDLRAPDVVIGADTIVTV 83
Cdd:PRK14363   2 RIILASSSprrrqlmellGIEFEVEKPDVEEEF--------LESPEETVRELSLRKAEWVFKKRKEEEILVIGSDTVVVL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  84 GGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHCSSKDhqldtrvsEFYEETKVKFSELSEELLWEYVHSGEPMDKA 163
Cdd:PRK14363  74 DGNILGKPESLEEAKGMLKKLSGRWHVVYTGVAFVSSETKD--------VIVSSTKVRFRELPESVIDYYVEKYRPLDKA 145

                        170       180
                 ....*....|....*....|....*...
gi 194387700 164 GGYGIQALGGMLVESVHGDFLNVVGFPL 191
Cdd:PRK14363 146 GAYGIQDFAAVFVEKIEGDFFTVVGFPL 173
PRK14368 PRK14368
Maf-like protein; Provisional
 13-191 5.78e-36

Maf-like protein; Provisional


Pssm-ID: 237693  Cd Length: 193  Bit Score: 133.37  E-value: 5.78e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  13 KRVVLASNAGLRFEVVPSKFKEKLdkASFATPYGYAMETAKQKALEVANRlyqkdlRAPDVVIGADTIVTVGGLILEKPV 92
Cdd:PRK14368  15 RRSELLASAGIEFDVVPADIPEEP--LPGEEPVDHVLRLAREKARAAAAL------AEGRFFIGADTIVVCDGEIMGKPK 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  93 DKQDAYRMLSRLSGREHSVFTGVAIVhcsskDHQLDTRVSEFYEeTKVKFSELSEELLWEYVHSGEPMDKAGGYGIQALG 172
Cdd:PRK14368  87 DEADAVRMLKKLSGVPHEVITGFAVY-----DRERDGCVTKAVR-TKVFFKPLRDEEIRDYIATGCPMDKAGAYAIQGGA 160

                        170
                 ....*....|....*....
gi 194387700 173 GMLVESVHGDFLNVVGFPL 191
Cdd:PRK14368 161 AHMVRKIDGSYTNVVGLPL 179
PRK14361 PRK14361
Maf-like protein; Provisional
 13-191 1.96e-34

Maf-like protein; Provisional


Pssm-ID: 172837  Cd Length: 187  Bit Score: 128.90  E-value: 1.96e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  13 KRVVLASNAGLRFEVVPSKFKEKLDKASfatPYGYAMETAKQKALEVAnRLYqkdlraPD-VVIGADTIVTVGGLILEKP 91
Cdd:PRK14361   9 RRRELLENLGVPFQVVVSGEAEDSTETD---PARLAAELALLKARAVA-RLH------PDaVVIAADTVVALGGVLLAKP 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  92 VDKQDAYRMLSRLSGREHSVFTGVAIVHCSSKDHQLdtrvsefyEETKVKFSELSEELLWEYVHSGEPMDKAGGYGIQAL 171
Cdd:PRK14361  79 ADEAENEAFLRVLSGRTHQVYTGVAVLSRGTEQVGV--------ERTDVTFRALTAAEISFYARSGEGLDKAGGYGIQGV 150

                        170       180
                 ....*....|....*....|
gi 194387700 172 GGMLVESVHGDFLNVVGFPL 191
Cdd:PRK14361 151 GMALVSRVEGDYSNVVGFPL 170
PRK14365 PRK14365
Maf-like protein; Provisional
 13-201 9.38e-33

Maf-like protein; Provisional


Pssm-ID: 237690  Cd Length: 197  Bit Score: 124.55  E-value: 9.38e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  13 KRVVLASNAGLR-----------FEVVPSKFKE----KLDKASFAtpygyaMETAKQKALEVAnrlyqkdLRAPD-VVIG 76
Cdd:PRK14365   2 RRIILASASPRRkellkqligdnFLVYPSSYEEppqpGLDPEELL------LKHSLEKARDVA-------KHFDSgIIIS 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  77 ADTIVTVGGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVhcsskDHQLDTRVSEfYEETKVKFSELSEELLWEYVHS 156
Cdd:PRK14365  69 ADTSVFCNGEVLGKPASPENAEEMLEKLSGRKFLVITGLTVL-----DLDSGKEISE-IESTDVWMTELSREQILAYVRT 142

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 194387700 157 GEPMDKAGGYGIQALGGMLVESVHGDFLNVVGFPLNHFCKQLVKL 201
Cdd:PRK14365 143 GEPLDKAGAFAIQGKGAVLVEKIEGDFFNVVGLPLFRLGKILEKL 187
dimerization2 pfam16864
dimerization domain; This domain, found in methyltransferases, functions as a dimerization ...
 278-361 2.17e-32

dimerization domain; This domain, found in methyltransferases, functions as a dimerization domain.


Pssm-ID: 465287  Cd Length: 87  Bit Score: 119.59  E-value: 2.17e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  278 LLELIEGFMLSKGLLTACKLKVFDLLKdEAPQKAADIASKVDASACGMERLLDICAAMGLLEKTEQ----GYSNTETANV 353
Cdd:pfam16864   1 LLDLIDGFRASKVLFTACELGVFDLLA-EGPLSAEEVAARLGASVDGTERLLDACVALGLLEREKTdgkgLYSNTELAST 79


                  ....*...
gi 194387700  354 YLASDGEY 361
Cdd:pfam16864  80 YLVSSSPK 87
PRK14362 PRK14362
Maf-like protein; Provisional
 14-200 1.12e-31

Maf-like protein; Provisional


Pssm-ID: 172838  Cd Length: 207  Bit Score: 121.89  E-value: 1.12e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  14 RVVLASNA----------GLRFEVV------PSKFKEKLdkasfatPYGYAMETAKQKALEVANRlyqkdlRAPDVVIGA 77
Cdd:PRK14362  13 PVVLASGSprrrefleqmGLPFEVIlpgaaePSPIEGEQ-------PEAYARRAAEAKARAVAAD------HAGRLVIAA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  78 DTIVTVGGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVhcsskdhQLDTRVSEFYEETKVKFSELSEELLWEYVHSG 157
Cdd:PRK14362  80 DTVVALDGMILGKPADRADALSMLRRLAGRTHEVVSACCVV-------LPDGGREVFHAITRVTMWDWPEAALAAYVATG 152

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 194387700 158 EPMDKAGGYGIQALGGMLVESVHGDFLNVVGFPLNHFCKQLVK 200
Cdd:PRK14362 153 EPSDKAGAYGIQGIGAFLVRSIEGSWSNVVGLPVAELTALLLR 195
PRK14367 PRK14367
Maf-like protein; Provisional
 13-207 5.29e-28

Maf-like protein; Provisional


Pssm-ID: 237692  Cd Length: 202  Bit Score: 111.31  E-value: 5.29e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  13 KRVVLASNAGLRFEVVPSKFKEKLDKASfaTPYGYAMETAKQKALEVANRLYQKDLRAPDV-VIGADTIVTVGGLILEKP 91
Cdd:PRK14367  12 RRMEILTQLGYRVVKLPAGIDETVKAGE--TPARYVQRMAEEKNRTALTLFCETNGTMPDFpLITADTCVVSDGIILGKP 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  92 VDKQDAYRMLSRLSGREHSVFTGVAIVHCSSKDHQLDTrvsefyeeTKVKFSELSEELLWEYVHSGEPMDKAGGYGIQAL 171
Cdd:PRK14367  90 RSQAEAIEFLNRLSGKQHTVLTAVCIHYRGKTSSRVQT--------NRVVFKPLSSEEISAYVQSGEPMDKAGAYAVQGI 161

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 194387700 172 GGMLVESVHGDFLNVVGFPLNHFCKQLVKL-YYPPRP 207
Cdd:PRK14367 162 GGIFIQSIEGSFSGIMGLPVYETVSMLQDLgYRSPLS 198
Maf_Ham1 cd00985
Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum ...
 15-143 4.68e-26

Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard nucleotides, such as hypoxanthine/xanthine NTP, but not standard nucleotides.


Pssm-ID: 238485  Cd Length: 131  Bit Score: 103.35  E-value: 4.68e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  15 VVLASN-----------AGLRFEVVPSKFKEKLDKASfatPYGYAMETAKQKALEVANRLyqkdlrAPDVVIGADTIVTV 83
Cdd:cd00985    1 LILASGsprrleelkqiGGIEFEVLPSDIDETGLKGE---PEDTVEELALLKARAVAERL------PDAPVIADDTGLVV 71

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  84 GGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHcsskdhqLDTRVSEFYEETKVKFS 143
Cdd:cd00985   72 DGRPGGKPARFAEALEMLRGLSGRTAEFVTAVALVD-------PDGKIITFEGETEGKIA 124
PRK14364 PRK14364
Maf-like protein; Provisional
 13-200 7.02e-26

Maf-like protein; Provisional


Pssm-ID: 184648  Cd Length: 181  Bit Score: 104.70  E-value: 7.02e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  13 KRVVLASNAGLRFEVVPSKFKEKLDKASfaTPYGYAMETAKQKALEVANRLyqkdlraPD-VVIGADTIVTVGGLILEKP 91
Cdd:PRK14364   7 RRRELLQQLGLNFEIYSPDIDESVHEGE--LVHQYVERLAREKAQAVLNIF-------PDsVIIAADTSLGLDGQIIGKP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  92 VDKQDAYRMLSRLSGREHSVFTGVAIvhcSSKDHQLDTRVsefyeETKVKFSELSEELLWEYVHSGEPMDKAGGYGIQAL 171
Cdd:PRK14364  78 DSKQHAFDIWKQLSGRWHDVFSGICI---ATQQQILSQVV-----QTQVEFASLTTQDMEDYWATGEPVGKAGAYAIQGI 149

                        170       180
                 ....*....|....*....|....*....
gi 194387700 172 GGMLVESVHGDFLNVVGFPLNHFCkQLVK 200
Cdd:PRK14364 150 ASQYIPKIQGSYSNVVGLPLYEFS-QLFK 177
PRK14366 PRK14366
Maf-like protein; Provisional
 26-191 2.41e-23

Maf-like protein; Provisional


Pssm-ID: 237691  Cd Length: 195  Bit Score: 97.95  E-value: 2.41e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  26 EVVPSKFKEKLDKASFatPYGYAMETAKQKALEVANrlyqkdLRAPDVVIGADTIVTVGGLILEKPVDKQDAYRMLSRLS 105
Cdd:PRK14366  29 EIVSPDIDESPLKKEL--PKDYSIRMAKEKAEKVQS------LRPDKFVLGADTVVCCGRRILLKAETEEQAEEYLELLS 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700 106 GREHSVFTGVAIVHCSSKDHqLDTRVsefyeeTKVKFSELSEELLWEYVHSGEPMDKAGGYGIQALGGMLVESVHGDFLN 185
Cdd:PRK14366 101 GRRHRVYTSVCLYTPGGKLH-IRSVV------TVVKFKRLSKQEIKYYIASGEWKGKAGGCNIQGLAGKFVLSINGSYSS 173


                 ....*.
gi 194387700 186 VVGFPL 191
Cdd:PRK14366 174 IIGLPL 179
PRK01441 PRK01441
Maf-like protein; Reviewed
 13-191 3.58e-23

Maf-like protein; Reviewed


Pssm-ID: 167232  Cd Length: 207  Bit Score: 97.86  E-value: 3.58e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  13 KRVVLASNAGLRFE-VVPSKFKEKLDKASFatPYGYAMETAKQKALEVANRLYQKDLRAPDVVIGADTIVTVGGLILEKP 91
Cdd:PRK01441  15 RRVELLNQAGIEPDrLMPADIDETPKRAEH--PRSLARRLSREKAEAALEALQGDDDWRGAYILAADTVVAVGRRILPKA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  92 VDKQDAYRMLSRLSGREHSVFTGVAIVhcsSKDHQLDTRVSEfyeeTKVKFSELSEELLWEYVHSGEPMDKAGGYGIQAL 171
Cdd:PRK01441  93 ELVDEASQCLRLLSGRNHRVYTGVCLV---TPDGKLRQKLVE----TRVRFKRLSREDIEAYLASGEWRGKAGGYAIQGI 165

                        170       180
                 ....*....|....*....|
gi 194387700 172 GGMLVESVHGDFLNVVGFPL 191
Cdd:PRK01441 166 AGSFVVKLVGSYTNVVGLPL 185
PRK04694 PRK04694
Maf-like protein; Reviewed
 38-193 6.87e-22

Maf-like protein; Reviewed


Pssm-ID: 179873  Cd Length: 190  Bit Score: 93.49  E-value: 6.87e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  38 KASFATPYGYAMETAKQKALEVANRLYQKDlrAPDVVIGADTIVTVGGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAI 117
Cdd:PRK04694  33 RAADESPDHYVQRVALEKAHAGLALVQAAD--ADAIVLGSDTEVVLGERVFGKPVDVDDAIAMLRALSGRTHQVLTAVVL 110

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194387700 118 VhCSSKDHQLDTRVSEfyeetkVKFSELSEELLWEYVHSGEPMDKAGGYGIQALGGMLVESVHGDFLNVVGFPLNH 193
Cdd:PRK04694 111 V-CAQRAPAQALVVSE------VTFDLLDDAQIAAYAASGEPMGKAGAYAIQGRAERFIRHLSGSYSGVMGLPLYQ 179
PRK02478 PRK02478
Maf-like protein; Reviewed
 14-191 1.96e-14

Maf-like protein; Reviewed


Pssm-ID: 167380  Cd Length: 199  Bit Score: 72.08  E-value: 1.96e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  14 RVVLASNAGLRFEVVPSKFKEK-----LDKASfATPYGYAMETAKQKALEVANRLyqkdlraPD-VVIGADTIVTVGGLI 87
Cdd:PRK02478  14 RRALLENAGLEFSAAAADIDERaveapLEESG-ATPEDVALVLAEAKAIDVSERF-------PGaLVIGCDQTMSLGDEV 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  88 LEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHcsskdhqldtrvsefyeetkvkfselSEELLWEYV------------- 154
Cdd:PRK02478  86 FHKPKDMEEARRHLQKLSGKTHQLNSAVVLVR--------------------------DGKVLWRHVsiahmtmrdldag 139

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 194387700 155 ----HSGEPMDKA----GGYGIQALGGMLVESVHGDFLNVVGFPL 191
Cdd:PRK02478 140 figrHLARVGEKAlssvGAYQLEGEGIQLFEKIEGDYFTILGLPL 184
PRK04056 PRK04056
septum formation inhibitor Maf;
14-189 3.14e-14

septum formation inhibitor Maf;


Pssm-ID: 179732  Cd Length: 180  Bit Score: 71.15  E-value: 3.14e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  14 RVVLASNAGLRFEVVPSKFKEKLDKASfaTPYGYAMETAKQKaLEVANRLYQKDlrapDVVIGADTIVTVGGLILEKPVD 93
Cdd:PRK04056  11 RANLLKEAGIEFEQKSLDFDEESIKKT--SPKEFVYLAVKGK-LEQFLKKYGNE----CNLLVADSVVSCGNKILRKAKD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  94 KQDAYRMLSRLSGREHSVFTGVAIVhcsSKDHQLDtRVSefyeETKVKFSELSEELLWEYVHSGEPMDKAggygiqalGG 173
Cdd:PRK04056  84 KEEAREMLKLQSGNEISVLTCMILK---SPEKEWL-DLS----VTTYRFKKFDEDDLEKYLESGLWQGKA--------GA 147

                        170
                 ....*....|....*..
gi 194387700 174 MLVESVHGDFL-NVVGF 189
Cdd:PRK04056 148 CMVEGFHKKYIkSVSGN 164
PRK02141 PRK02141
Maf-like protein; Reviewed
 14-205 1.06e-12

Maf-like protein; Reviewed


Pssm-ID: 235009  Cd Length: 207  Bit Score: 67.47  E-value: 1.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  14 RVVLASNAGLR----------FEVVPSKFKEKldKASFATPYGYAMETAKQKALEVANRLyqkdlRAPD--VVIGADTIV 81
Cdd:PRK02141  10 RLILASSSRYRrellerlrlpFDVVSPDIDET--PLAGETPAATALRLAAAKARAVAATI-----DAPPgaLVIGSDQVA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  82 TVGGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHCSSKDHQLDTRVsefyeeTKVKFSELSEELLWEYVHSGEPMD 161
Cdd:PRK02141  83 TFDGLQIGKPGTHERALAQLQAMRGRTVEFHSALCLYDSRTGETQSEDVV------TRVRFRTLTDAELDAYLRAETPYD 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 194387700 162 KAGGYGIQALGGMLVESVHG-DFLNVVGFPLNHFCKQLVKLYYPP 205
Cdd:PRK02141 157 VAGSAKSEGLGIALLDAIDSdDPTALVGLPLIALTRMLRAAGYPL 201
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 447-539 3.03e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 51.41  E-value: 3.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  447 DVGGCTGALARELAREYPRmQVTVFDL-PDIIELA-AHFQPPGPqavQIHFAAGDFFRDPLPSAEL-YVLCR-ILHDWPD 522
Cdd:pfam13649   3 DLGCGTGRLTLALARRGGA-RVTGVDLsPEMLERArERAAEAGL---NVEFVQGDAEDLPFPDGSFdLVVSSgVLHHLPD 78

                          90
                  ....*....|....*..
gi 194387700  523 DKVHKLLSKVAESCKPG 539
Cdd:pfam13649  79 PDLEAALREIARVLKPG 95
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 430-562 2.15e-06

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 48.76  E-value: 2.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700 430 ACQVATAFNLSRFSSACDVGgC-TGALARELAREYpRMQVTVFDL-PDIIELAAHFQPPGPQAvQIHFAAGDFFRD---P 504
Cdd:COG0500   15 AALLALLERLPKGGRVLDLG-CgTGRNLLALAARF-GGRVIGIDLsPEAIALARARAAKAGLG-NVEFLVADLAELdplP 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 194387700 505 LPSAELYVLCRILHDWPDDKVHKLLSKVAESCKPGAGLLLVETLLDEEKRVAQRALMQ 562
Cdd:COG0500   92 AESFDLVVAFGVLHHLPPEEREALLRELARALKPGGVLLLSASDAAAALSLARLLLLA 149
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 432-558 4.61e-06

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 46.53  E-value: 4.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700 432 QVATAFNLSRFSSACDVGGCTGALARELAREYPRmqVTVFDL-PDIIELAAHFQPpgPQAVQIHFAAGDFFRDPLPSAEL 510
Cdd:COG2226   13 ALLAALGLRPGARVLDLGCGTGRLALALAERGAR--VTGVDIsPEMLELARERAA--EAGLNVEFVVGDAEDLPFPDGSF 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 194387700 511 -YVLCR-ILHDWPDdkVHKLLSKVAESCKPGAGLLLVETLLDEEKRVAQR 558
Cdd:COG2226   89 dLVISSfVLHHLPD--PERALAEIARVLKPGGRLVVVDFSPPDLAELEEL 136
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 447-542 6.37e-06

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 45.05  E-value: 6.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  447 DVGGCTGALARELAREYPRMQVTVFDL-PDIIELAAHF--QPPGPQAVQIHFAAGDFFRDPLPSAELYVLCRILHDWPDd 523
Cdd:pfam08242   2 EIGCGTGTLLRALLEALPGLEYTGLDIsPAALEAARERlaALGLLNAVRVELFQLDLGELDPGSFDVVVASNVLHHLAD- 80

                          90
                  ....*....|....*....
gi 194387700  524 kVHKLLSKVAESCKPGAGL 542
Cdd:pfam08242  81 -PRAVLRNIRRLLKPGGVL 98
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 443-547 9.21e-05

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 42.31  E-value: 9.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700 443 SSACDVGGCTGALARELAREypRMQVTVFDL-PDIIELAAHFQPpgpqAVQIHFAAGDFFRDPLP--SAELYVLCRILHD 519
Cdd:COG2227   26 GRVLDVGCGTGRLALALARR--GADVTGVDIsPEALEIARERAA----ELNVDFVQGDLEDLPLEdgSFDLVICSEVLEH 99

                         90       100
                 ....*....|....*....|....*...
gi 194387700 520 WPDdkVHKLLSKVAESCKPGaGLLLVET 547
Cdd:COG2227  100 LPD--PAALLRELARLLKPG-GLLLLST 124
SpeE COG0421
Spermidine synthase (polyamine aminopropyltransferase) [Amino acid transport and metabolism];
448-504 2.53e-04

Spermidine synthase (polyamine aminopropyltransferase) [Amino acid transport and metabolism];


Pssm-ID: 440190 [Multi-domain]  Cd Length: 195  Bit Score: 42.51  E-value: 2.53e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 194387700 448 VGGCTGALARELAREYPRMQVTVFDL-PDIIELA-AHFQPPGPQA----VQIHFA-AGDFFRDP 504
Cdd:COG0421   44 IGGGDGGLARELLKHPPVERVDVVEIdPEVVELArEYFPLLAPAFddprLRVVIGdGRAFLREA 107
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 447-545 1.03e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 38.41  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700  447 DVGGCTGALARELAREYPRmqVTVFDL-PDIIELAAHFQPPgpqaVQIHFAAGDFFRDPLP--SAELYVLCRILHDWPDd 523
Cdd:pfam08241   2 DVGCGTGLLTELLARLGAR--VTGVDIsPEMLELAREKAPR----EGLTFVVGDAEDLPFPdnSFDLVLSSEVLHHVED- 74

                          90       100
                  ....*....|....*....|..
gi 194387700  524 kVHKLLSKVAESCKPGaGLLLV 545
Cdd:pfam08241  75 -PERALREIARVLKPG-GILII 94
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 447-549 2.10e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 38.18  E-value: 2.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194387700 447 DVGGCTGALARELAREYPRmQVTVFDL-PDIIELAAHFQPpGPQAVQIHFAAGDFFRDPLPSAELY--VLCRILHDWPDD 523
Cdd:cd02440    4 DLGCGTGALALALASGPGA-RVTGVDIsPVALELARKAAA-ALLADNVEVLKGDAEELPPEADESFdvIISDPPLHHLVE 81

                         90       100
                 ....*....|....*....|....*.
gi 194387700 524 KVHKLLSKVAESCKPGaGLLLVETLL 549
Cdd:cd02440   82 DLARFLEEARRLLKPG-GVLVLTLVL 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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