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Conserved domains on  [gi|194377052|dbj|BAG63087|]
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unnamed protein product [Homo sapiens]

Protein Classification

MAGE domain-containing protein( domain architecture ID 10477727)

MAGE (Melanoma-associated antigen) domain-containing protein similar to Homo sapiens melanoma-associated antigen F1 and non-structural maintenance of chromosomes element 3 homolog

CATH:  1.10.10.1210|1.10.10.1200
SCOP:  4006335

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MAGE pfam01454
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
 74-190 2.97e-20

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


:

Pssm-ID: 426270  Cd Length: 205  Bit Score: 85.02  E-value: 2.97e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377052   74 LVKYLLAKDQTKIPIKRSDMLKDIIKEY-TDVYPEIIERAGYSLEKVFGIQLKEIDKNDHL------------------- 133
Cdd:pfam01454   1 LVRYALACEYQRTPIRREDISKKVLGENrKRLFKKVFEEAQKILRDVFGMELVELPAKEEKkttvtsqqrraaakssrsk 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194377052  134 -YILLSTLEPT--DAGILGTTK---------DSPKLGLLMVLLSIIFMNGNRSSEAVIWEVLRKLGLRP 190
Cdd:pfam01454  81 sYILVSTLPPEyrVPAIIWPSKapsfvldqdEATYTGILTVILSLILLSGGSISEQELLRYLRRLGIDT 149
 
Name Accession Description Interval E-value
MAGE pfam01454
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
 74-190 2.97e-20

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


Pssm-ID: 426270  Cd Length: 205  Bit Score: 85.02  E-value: 2.97e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377052   74 LVKYLLAKDQTKIPIKRSDMLKDIIKEY-TDVYPEIIERAGYSLEKVFGIQLKEIDKNDHL------------------- 133
Cdd:pfam01454   1 LVRYALACEYQRTPIRREDISKKVLGENrKRLFKKVFEEAQKILRDVFGMELVELPAKEEKkttvtsqqrraaakssrsk 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194377052  134 -YILLSTLEPT--DAGILGTTK---------DSPKLGLLMVLLSIIFMNGNRSSEAVIWEVLRKLGLRP 190
Cdd:pfam01454  81 sYILVSTLPPEyrVPAIIWPSKapsfvldqdEATYTGILTVILSLILLSGGSISEQELLRYLRRLGIDT 149
 
Name Accession Description Interval E-value
MAGE pfam01454
MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide ...
 74-190 2.97e-20

MAGE homology domain; The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.


Pssm-ID: 426270  Cd Length: 205  Bit Score: 85.02  E-value: 2.97e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194377052   74 LVKYLLAKDQTKIPIKRSDMLKDIIKEY-TDVYPEIIERAGYSLEKVFGIQLKEIDKNDHL------------------- 133
Cdd:pfam01454   1 LVRYALACEYQRTPIRREDISKKVLGENrKRLFKKVFEEAQKILRDVFGMELVELPAKEEKkttvtsqqrraaakssrsk 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194377052  134 -YILLSTLEPT--DAGILGTTK---------DSPKLGLLMVLLSIIFMNGNRSSEAVIWEVLRKLGLRP 190
Cdd:pfam01454  81 sYILVSTLPPEyrVPAIIWPSKapsfvldqdEATYTGILTVILSLILLSGGSISEQELLRYLRRLGIDT 149
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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