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Conserved domains on  [gi|194306569|ref|NP_001123584|]
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replication factor C subunit 5 isoform 3 [Homo sapiens]

Protein Classification

replication factor C small subunit( domain architecture ID 1001945)

replication factor C small subunit is part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
rfc super family cl35099
replication factor C small subunit; Reviewed
 3-244 5.29e-94

replication factor C small subunit; Reviewed


The actual alignment was detected with superfamily member PRK00440:

Pssm-ID: 234763 [Multi-domain]  Cd Length: 319  Bit Score: 279.07  E-value: 5.29e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   3 LELNASDDRGIDIIRGPILSFASTRTIFKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQS 82
Cdd:PRK00440  72 LELNASDERGIDVIRNKIKEFARTAPVGGAPFKIIFLDEADNLTSDAQQALRRTMEMYSQNTRFILSCNYSSKIIDPIQS 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  83 RCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTNMAFGKVTEETVYTCTGHPLKSDI 162
Cdd:PRK00440 152 RCAVFRFSPLKKEAVAERLRYIAENEGIEITDDALEAIYYVSEGDMRKAINALQAAAATGKEVTEEAVYKITGTARPEEI 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569 163 ANILDWMLNQDFTTAYRNITELKTLKGLALHDILTEIHLFVHRVDFPSSVRIHLLTKMADIEYRLSVGTNEKIQLSSLIA 242
Cdd:PRK00440 232 REMIELALNGDFTEAREKLRDLMIDYGLSGEDIIKQIHREVWSLDIPEELKVELIDAIGEADFRITEGANERIQLEALLA 311


                 ..
gi 194306569 243 AF 244
Cdd:PRK00440 312 KL 313
 
Name Accession Description Interval E-value
rfc PRK00440
replication factor C small subunit; Reviewed
 3-244 5.29e-94

replication factor C small subunit; Reviewed


Pssm-ID: 234763 [Multi-domain]  Cd Length: 319  Bit Score: 279.07  E-value: 5.29e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   3 LELNASDDRGIDIIRGPILSFASTRTIFKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQS 82
Cdd:PRK00440  72 LELNASDERGIDVIRNKIKEFARTAPVGGAPFKIIFLDEADNLTSDAQQALRRTMEMYSQNTRFILSCNYSSKIIDPIQS 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  83 RCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTNMAFGKVTEETVYTCTGHPLKSDI 162
Cdd:PRK00440 152 RCAVFRFSPLKKEAVAERLRYIAENEGIEITDDALEAIYYVSEGDMRKAINALQAAAATGKEVTEEAVYKITGTARPEEI 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569 163 ANILDWMLNQDFTTAYRNITELKTLKGLALHDILTEIHLFVHRVDFPSSVRIHLLTKMADIEYRLSVGTNEKIQLSSLIA 242
Cdd:PRK00440 232 REMIELALNGDFTEAREKLRDLMIDYGLSGEDIIKQIHREVWSLDIPEELKVELIDAIGEADFRITEGANERIQLEALLA 311


                 ..
gi 194306569 243 AF 244
Cdd:PRK00440 312 KL 313
HolB COG0470
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
2-245 4.51e-45

DNA polymerase III, delta prime subunit [Replication, recombination and repair];


Pssm-ID: 440238 [Multi-domain]  Cd Length: 289  Bit Score: 152.82  E-value: 4.51e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   2 VLELNA---SDDRGIDIIRGpILSFASTRTIFKkGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIP 78
Cdd:COG0470   69 LLELNPeekSDQIGIDQIRE-LGEFLSLTPLEG-GRKVVIIDEADAMNEAAANALLKTLEEPPKNTPFILIANDPSRLLP 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  79 ALQSRCTRFRFGPLTPELMVPRLehvvEEEKVDisEDGMKALVTLSSGDMRRALNILQStnMAFGKVTEETVYTCTGHP- 157
Cdd:COG0470  147 TIRSRCQVIRFRPPSEEEALAWL----REEGVD--EDALEAILRLAGGDPRAAINLLQA--LAGRKELLEDLAALLSRDr 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569 158 --------LKSDIANILDWMLNQdfttayrnitelktlkglaLHDILteihlfvhRVDFPSSVRIHLLTKMADIEYRLSV 229
Cdd:COG0470  219 alelldalLKAEALELLDWLLKW-------------------LLDNL--------PLEYAGEDLARAYEALSEADRRLGR 271

                        250
                 ....*....|....*.
gi 194306569 230 GTNEKIQLSSLIAAFQ 245
Cdd:COG0470  272 YANDRLLLEALLAKLG 287
Rep_fac_C pfam08542
Replication factor C C-terminal domain; This is the C-terminal domain of RFC (replication ...
 157-243 4.86e-31

Replication factor C C-terminal domain; This is the C-terminal domain of RFC (replication factor-C) protein of the clamp loader complex which binds to the DNA sliding clamp (proliferating cell nuclear antigen, PCNA). The five modules of RFC assemble into a right-handed spiral, which results in only three of the five RFC subunits (RFC-A, RFC-B and RFC-C) making contact with PCNA, leaving a wedge-shaped gap between RFC-E and the PCNA clamp-loader complex. The C-terminal is vital for the correct orientation of RFC-E with respect to RFC-A.


Pssm-ID: 462513 [Multi-domain]  Cd Length: 87  Bit Score: 110.26  E-value: 4.86e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  157 PLKSDIANILDWMLNQDFTTAYRNITELKTLKGLALHDILTEIHLFVHRVDFPSSVRIHLLTKMADIEYRLSVGTNEKIQ 236
Cdd:pfam08542   1 PHPEDIEEILNSCLNGDFDEAYKKVRELLVEKGYSLQDIITQLHRVVKSLDLPEEVKLELLEKLGEIEYRLSEGASEKLQ 80


                  ....*..
gi 194306569  237 LSSLIAA 243
Cdd:pfam08542  81 LSALLAA 87
HLD_clamp_RFC cd18140
helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein ...
 92-154 1.91e-20

helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein clamp loader complex that forms a stable ATP-dependent complex with the sliding clamp, PCNA, which binds specifically to primed DNA. RFC subunits belong to the clamp loader clade of the AAA+ superfamily.


Pssm-ID: 350842 [Multi-domain]  Cd Length: 63  Bit Score: 81.81  E-value: 1.91e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194306569  92 LTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTNMAFGKVTEETVYTCT 154
Cdd:cd18140    1 LSKEQIVKRLREICKKEGVKIDEEALEAIAEKSEGDMRKAINDLQAAAAGGGVITEEDVYEVA 63
holB TIGR00678
DNA polymerase III, delta' subunit; This model describes the N-terminal half of the delta' ...
 12-103 5.51e-14

DNA polymerase III, delta' subunit; This model describes the N-terminal half of the delta' subunit of DNA polymerase III. Delta' is homologous to the gamma and tau subunits, which form an outgroup for phylogenetic comparison. The gamma/tau branch of the tree is much more tighly conserved than the delta' branch, and some members of that branch score more highly against this model than some proteins classisified as delta'. The noise cutoff is set to detect weakly scoring delta' subunits rather than to exclude gamma/tau subunits. At position 126-127 of the seed alignment, this family lacks the HM motif of gamma/tau; at 132 it has a near-invariant A vs. an invariant F in gamma/tau. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273213 [Multi-domain]  Cd Length: 188  Bit Score: 68.04  E-value: 5.51e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   12 GIDIIRGpILSFASTRTIfKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGP 91
Cdd:TIGR00678  77 KVDQVRE-LVEFLSRTPQ-ESGRRVVIIEDAERMNEAAANALLKTLEEPPPNTLFILITPSPEKLLPTIRSRCQRLPFPP 154

                          90
                  ....*....|..
gi 194306569   92 LTPELMVPRLEH 103
Cdd:TIGR00678 155 LSEEALLQWLIR 166
 
Name Accession Description Interval E-value
rfc PRK00440
replication factor C small subunit; Reviewed
 3-244 5.29e-94

replication factor C small subunit; Reviewed


Pssm-ID: 234763 [Multi-domain]  Cd Length: 319  Bit Score: 279.07  E-value: 5.29e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   3 LELNASDDRGIDIIRGPILSFASTRTIFKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQS 82
Cdd:PRK00440  72 LELNASDERGIDVIRNKIKEFARTAPVGGAPFKIIFLDEADNLTSDAQQALRRTMEMYSQNTRFILSCNYSSKIIDPIQS 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  83 RCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTNMAFGKVTEETVYTCTGHPLKSDI 162
Cdd:PRK00440 152 RCAVFRFSPLKKEAVAERLRYIAENEGIEITDDALEAIYYVSEGDMRKAINALQAAAATGKEVTEEAVYKITGTARPEEI 231

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569 163 ANILDWMLNQDFTTAYRNITELKTLKGLALHDILTEIHLFVHRVDFPSSVRIHLLTKMADIEYRLSVGTNEKIQLSSLIA 242
Cdd:PRK00440 232 REMIELALNGDFTEAREKLRDLMIDYGLSGEDIIKQIHREVWSLDIPEELKVELIDAIGEADFRITEGANERIQLEALLA 311


                 ..
gi 194306569 243 AF 244
Cdd:PRK00440 312 KL 313
PRK04132 PRK04132
replication factor C small subunit; Provisional
 3-244 7.95e-65

replication factor C small subunit; Provisional


Pssm-ID: 235223 [Multi-domain]  Cd Length: 846  Bit Score: 216.24  E-value: 7.95e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   3 LELNASDDRGIDIIRGPILSFASTRTIFKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQS 82
Cdd:PRK04132 600 LELNASDERGINVIREKVKEFARTKPIGGASFKIIFLDEADALTQDAQQALRRTMEMFSSNVRFILSCNYSSKIIEPIQS 679

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  83 RCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTNMAFGKVTEETVYTCTGHPLKSDI 162
Cdd:PRK04132 680 RCAIFRFRPLRDEDIAKRLRYIAENEGLELTEEGLQAILYIAEGDMRRAINILQAAAALDDKITDENVFLVASRARPEDI 759

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569 163 ANILDWMLNQDFTTAYRNITELKTLKGLALHDILTEIHLFVHRVDFPSSVRIHLLTKMADIEYRLSVGTNEKIQLSSLIA 242
Cdd:PRK04132 760 REMMLLALKGNFLKAREKLREILLKQGLSGEDVLVQMHREVFNLPIDEPKKVELADKIGEYNFRLVEGANEMIQLEALLA 839


                 ..
gi 194306569 243 AF 244
Cdd:PRK04132 840 QF 841
PLN03025 PLN03025
replication factor C subunit; Provisional
 2-249 1.17e-61

replication factor C subunit; Provisional


Pssm-ID: 178596 [Multi-domain]  Cd Length: 319  Bit Score: 196.49  E-value: 1.17e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   2 VLELNASDDRGIDIIRGPILSFASTRTIFKKG-FKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPAL 80
Cdd:PLN03025  67 VLELNASDDRGIDVVRNKIKMFAQKKVTLPPGrHKIVILDEADSMTSGAQQALRRTMEIYSNTTRFALACNTSSKIIEPI 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  81 QSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTNMAFGKVTEETVYTCTGHPLKS 160
Cdd:PLN03025 147 QSRCAIVRFSRLSDQEILGRLMKVVEAEKVPYVPEGLEAIIFTADGDMRQALNNLQATHSGFGFVNQENVFKVCDQPHPL 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569 161 DIANILDWMLNQDFTTAYRNITELKTLkGLALHDILTEIHLFVHRVDFPSSVRIHLLTKMADIEYRLSVGTNEKIQLSSL 240
Cdd:PLN03025 227 HVKNIVRNCLKGKFDDACDGLKQLYDL-GYSPTDIITTLFRVVKNYDMPEFLKLEYLREIGFAHMRICDGVGSLLQLSGL 305


                 ....*....
gi 194306569 241 IAAFQVTRD 249
Cdd:PLN03025 306 LAKLCLVRE 314
PRK12402 PRK12402
replication factor C small subunit 2; Reviewed
 7-244 6.89e-51

replication factor C small subunit 2; Reviewed


Pssm-ID: 237090 [Multi-domain]  Cd Length: 337  Bit Score: 169.40  E-value: 6.89e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   7 ASDDRGIDIIRGPILSFASTRTIFKK-------------GFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYL 73
Cdd:PRK12402  86 VEDPRFAHFLGTDKRIRSSKIDNFKHvlkeyasyrplsaDYKTILLDNAEALREDAQQALRRIMEQYSRTCRFIIATRQP 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  74 SKIIPALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTNMAFGKVTEETVYTC 153
Cdd:PRK12402 166 SKLIPPIRSRCLPLFFRAPTDDELVDVLESIAEAEGVDYDDDGLELIAYYAGGDLRKAILTLQTAALAAGEITMEAAYEA 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569 154 TGH-PLKSDIANILDWMLNQDFTTAYRNITELKTLKGLALHDILTEIHLFVHRVDFPSSV-RIHllTKMADIEYRLSVGT 231
Cdd:PRK12402 246 LGDvGTDEVIESLLDAAEAGDFTDARKTLDDLLIDEGLSGGEVLEELLRVARSRYRGDNLaRLH--RLAADADARLTDGA 323

                        250
                 ....*....|...
gi 194306569 232 NEKIQLSSLIAAF 244
Cdd:PRK12402 324 NDRIQLEALLAEL 336
HolB COG0470
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
2-245 4.51e-45

DNA polymerase III, delta prime subunit [Replication, recombination and repair];


Pssm-ID: 440238 [Multi-domain]  Cd Length: 289  Bit Score: 152.82  E-value: 4.51e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   2 VLELNA---SDDRGIDIIRGpILSFASTRTIFKkGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIP 78
Cdd:COG0470   69 LLELNPeekSDQIGIDQIRE-LGEFLSLTPLEG-GRKVVIIDEADAMNEAAANALLKTLEEPPKNTPFILIANDPSRLLP 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  79 ALQSRCTRFRFGPLTPELMVPRLehvvEEEKVDisEDGMKALVTLSSGDMRRALNILQStnMAFGKVTEETVYTCTGHP- 157
Cdd:COG0470  147 TIRSRCQVIRFRPPSEEEALAWL----REEGVD--EDALEAILRLAGGDPRAAINLLQA--LAGRKELLEDLAALLSRDr 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569 158 --------LKSDIANILDWMLNQdfttayrnitelktlkglaLHDILteihlfvhRVDFPSSVRIHLLTKMADIEYRLSV 229
Cdd:COG0470  219 alelldalLKAEALELLDWLLKW-------------------LLDNL--------PLEYAGEDLARAYEALSEADRRLGR 271

                        250
                 ....*....|....*.
gi 194306569 230 GTNEKIQLSSLIAAFQ 245
Cdd:COG0470  272 YANDRLLLEALLAKLG 287
Rep_fac_C pfam08542
Replication factor C C-terminal domain; This is the C-terminal domain of RFC (replication ...
 157-243 4.86e-31

Replication factor C C-terminal domain; This is the C-terminal domain of RFC (replication factor-C) protein of the clamp loader complex which binds to the DNA sliding clamp (proliferating cell nuclear antigen, PCNA). The five modules of RFC assemble into a right-handed spiral, which results in only three of the five RFC subunits (RFC-A, RFC-B and RFC-C) making contact with PCNA, leaving a wedge-shaped gap between RFC-E and the PCNA clamp-loader complex. The C-terminal is vital for the correct orientation of RFC-E with respect to RFC-A.


Pssm-ID: 462513 [Multi-domain]  Cd Length: 87  Bit Score: 110.26  E-value: 4.86e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  157 PLKSDIANILDWMLNQDFTTAYRNITELKTLKGLALHDILTEIHLFVHRVDFPSSVRIHLLTKMADIEYRLSVGTNEKIQ 236
Cdd:pfam08542   1 PHPEDIEEILNSCLNGDFDEAYKKVRELLVEKGYSLQDIITQLHRVVKSLDLPEEVKLELLEKLGEIEYRLSEGASEKLQ 80


                  ....*..
gi 194306569  237 LSSLIAA 243
Cdd:pfam08542  81 LSALLAA 87
44 PHA02544
clamp loader, small subunit; Provisional
 2-176 5.94e-30

clamp loader, small subunit; Provisional


Pssm-ID: 222866 [Multi-domain]  Cd Length: 316  Bit Score: 113.93  E-value: 5.94e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   2 VLELNASDDRgIDIIRGPILSFASTRTiFKKGFKLVILDEAD-AMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPAL 80
Cdd:PHA02544  71 VLFVNGSDCR-IDFVRNRLTRFASTVS-LTGGGKVIIIDEFDrLGLADAQRHLRSFMEAYSKNCSFIITANNKNGIIEPL 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  81 QSRCTRFRFGPLTPE-------LMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQStNMAFGKVTEETVYTC 153
Cdd:PHA02544 149 RSRCRVIDFGVPTKEeqiemmkQMIVRCKGILEAEGVEVDMKVLAALVKKNFPDFRRTINELQR-YASTGKIDAGILSEV 227

                        170       180
                 ....*....|....*....|...
gi 194306569 154 TGhplkSDIANILDWMLNQDFTT 176
Cdd:PHA02544 228 TN----SDIDDVVEALKAKDFKA 246
PRK14953 PRK14953
DNA polymerase III subunits gamma and tau; Provisional
 4-212 5.89e-27

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237867 [Multi-domain]  Cd Length: 486  Bit Score: 108.37  E-value: 5.89e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   4 ELNASDDRGIDIIRGpiLSFASTRTIFKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSR 83
Cdd:PRK14953  92 EIDAASNRGIDDIRA--LRDAVSYTPIKGKYKVYIIDEAHMLTKEAFNALLKTLEEPPPRTIFILCTTEYDKIPPTILSR 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  84 CTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL-QSTNMAFGKVTEETVYTCTGHPLKSDI 162
Cdd:PRK14953 170 CQRFIFSKPTKEQIKEYLKRICNEEKIEYEEKALDLLAQASEGGMRDAASLLdQASTYGEGKVTIKVVEEFLGIVSQESV 249

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 194306569 163 ANILDWMLNQDFTTAYRNITELKTlKGLALH----DILTEIH--LFVHRVDFPSSV 212
Cdd:PRK14953 250 RKFLNLLLESDVDEAIKFLRTLEE-KGYNLNkfwkQLEEEIRniLLNKSLKNPEEV 304
DnaX COG2812
DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];
11-241 7.57e-22

DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];


Pssm-ID: 442061 [Multi-domain]  Cd Length: 340  Bit Score: 92.56  E-value: 7.57e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  11 RGIDIIRGPI--LSFASTRTifkkGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFR 88
Cdd:COG2812   94 IGVDDIRELIekVSYAPVEG----RYKVYIIDEAHMLTTEAFNALLKTLEEPPPHVVFILATTEPQKLLPTILSRCQRFD 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  89 FGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQStNMAFGKV-TEETVYTCTGHPLKSDIANILD 167
Cdd:COG2812  170 FRRLPPEEIAEHLAKIAEREGIEIEPEALALIARAADGSMRDALSLLDQ-AIAFGLLdRRELLLDLLEALLAGDVAALLA 248

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569 168 W------------MLNQDFTTAYRNITELKTLKGLALH---DILTEIHLFVHRVDFPSSVRIhlLTKMADIEYRLSVGTN 232
Cdd:COG2812  249 LaeelakrgrdlkRFLDDLLSLLRDLLLLKLGPDAELLvneDERERLQELARRLSPERLLRA--IQILLEARRELERNVN 326


                 ....*....
gi 194306569 233 EKIQLSSLI 241
Cdd:COG2812  327 PRLALEMLL 335
PRK14962 PRK14962
DNA polymerase III subunits gamma and tau; Provisional
 2-155 9.60e-21

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237869 [Multi-domain]  Cd Length: 472  Bit Score: 90.59  E-value: 9.60e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   2 VLELNASDDRGIDIIRgPILSFASTRTIFKKgFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQ 81
Cdd:PRK14962  88 VIELDAASNRGIDEIR-KIRDAVGYRPMEGK-YKVYIIDEVHMLTKEAFNALLKTLEEPPSHVVFVLATTNLEKVPPTII 165

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194306569  82 SRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL-QSTNMAFGKVTEETVYTCTG 155
Cdd:PRK14962 166 SRCQVIEFRNISDELIIKRLQEVAEAEGIEIDREALSFIAKRASGGLRDALTMLeQVWKFSEGKITLETVHEALG 240
PRK04195 PRK04195
replication factor C large subunit; Provisional
 2-167 1.48e-20

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 89.98  E-value: 1.48e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   2 VLELNASDDRGIDIIRGPILSFASTRTIFKKGFKLVILDEADAM--TQDAQNAlrRVIEKFTENTRFCLIC---NYLSKI 76
Cdd:PRK04195  67 VIELNASDQRTADVIERVAGEAATSGSLFGARRKLILLDEVDGIhgNEDRGGA--RAILELIKKAKQPIILtanDPYDPS 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  77 IPALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTNMAFGKVTEETVYTCTGH 156
Cdd:PRK04195 145 LRELRNACLMIEFKRLSTRSIVPVLKRICRKEGIECDDEALKEIAERSGGDLRSAINDLQAIAEGYGKLTLEDVKTLGRR 224

                        170
                 ....*....|.
gi 194306569 157 PLKSDIANILD 167
Cdd:PRK04195 225 DREESIFDALD 235
HLD_clamp_RFC cd18140
helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein ...
 92-154 1.91e-20

helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein clamp loader complex that forms a stable ATP-dependent complex with the sliding clamp, PCNA, which binds specifically to primed DNA. RFC subunits belong to the clamp loader clade of the AAA+ superfamily.


Pssm-ID: 350842 [Multi-domain]  Cd Length: 63  Bit Score: 81.81  E-value: 1.91e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194306569  92 LTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTNMAFGKVTEETVYTCT 154
Cdd:cd18140    1 LSKEQIVKRLREICKKEGVKIDEEALEAIAEKSEGDMRKAINDLQAAAAGGGVITEEDVYEVA 63
PRK07133 PRK07133
DNA polymerase III subunits gamma and tau; Validated
 2-185 5.85e-18

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 235943 [Multi-domain]  Cd Length: 725  Bit Score: 82.94  E-value: 5.85e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   2 VLELNASDDRGIDIIRGPILSFASTRTIFKkgFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQ 81
Cdd:PRK07133  89 IIEMDAASNNGVDEIRELIENVKNLPTQSK--YKIYIIDEVHMLSKSAFNALLKTLEEPPKHVIFILATTEVHKIPLTIL 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  82 SRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL-QSTNMAFGKVTEETVYTCTGHPLKS 160
Cdd:PRK07133 167 SRVQRFNFRRISEDEIVSRLEFILEKENISYEKNALKLIAKLSSGSLRDALSIAeQVSIFGNNKITLKNVEELFGLVSNE 246

                        170       180
                 ....*....|....*....|....*
gi 194306569 161 DIANILDWMLNQDFTTAYRNITELK 185
Cdd:PRK07133 247 NLINLLNLLYSKDIKEVLNILNQIK 271
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 2-253 3.55e-17

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 80.52  E-value: 3.55e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   2 VLELNASDDRGIDIIRgPILSFASTRTIFKKgFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQ 81
Cdd:PRK08691  90 LLEIDAASNTGIDNIR-EVLENAQYAPTAGK-YKVYIIDEVHMLSKSAFNAMLKTLEEPPEHVKFILATTDPHKVPVTVL 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  82 SRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL-QSTNMAFGKVTEETVYTCTGHPLKS 160
Cdd:PRK08691 168 SRCLQFVLRNMTAQQVADHLAHVLDSEKIAYEPPALQLLGRAAAGSMRDALSLLdQAIALGSGKVAENDVRQMIGAVDKQ 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569 161 DIANILDWMLNQDFTTAYRNITELKTlKGLALHDILTEIHLFVHRVDFPSSVRIHLLTK--MADIEYRLSVG-TNEKIQL 237
Cdd:PRK08691 248 YLYELLTGIINQDGAALLAKAQEMAA-CAVGFDNALGELAILLQQLALIQAVPSALAHDdpDSDILHRLAQTiSGEQIQL 326

                        250
                 ....*....|....*.
gi 194306569 238 SSLIAAfQVTRDLIVA 253
Cdd:PRK08691 327 YYQIAV-HGKRDLSLA 341
PRK05896 PRK05896
DNA polymerase III subunits gamma and tau; Validated
 2-199 7.86e-16

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 235638 [Multi-domain]  Cd Length: 605  Bit Score: 76.42  E-value: 7.86e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   2 VLELNASDDRGIDIIRGPILSFASTRTIFKKgfKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQ 81
Cdd:PRK05896  90 IVELDAASNNGVDEIRNIIDNINYLPTTFKY--KVYIIDEAHMLSTSAWNALLKTLEEPPKHVVFIFATTEFQKIPLTII 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  82 SRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL-QSTNMAFGKVTEETVYTCTGHPLKS 160
Cdd:PRK05896 168 SRCQRYNFKKLNNSELQELLKSIAKKEKIKIEDNAIDKIADLADGSLRDGLSILdQLSTFKNSEIDIEDINKTFGLVDNN 247

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 194306569 161 DIANILDWMLNQDFTTAYRNITELKTlKGLALHDILTEI 199
Cdd:PRK05896 248 KKINLIELIQKNDIEELRNLINELES-KGINFEAFCRDL 285
PRK14964 PRK14964
DNA polymerase III subunits gamma and tau; Provisional
 2-177 1.31e-15

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237870 [Multi-domain]  Cd Length: 491  Bit Score: 75.59  E-value: 1.31e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   2 VLELNASDDRGIDIIRgPILSFASTRTIFKKgFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQ 81
Cdd:PRK14964  87 VIEIDAASNTSVDDIK-VILENSCYLPISSK-FKVYIIDEVHMLSNSAFNALLKTLEEPAPHVKFILATTEVKKIPVTII 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  82 SRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL-QSTNMAFGKVTEETVYTCTGHPLKS 160
Cdd:PRK14964 165 SRCQRFDLQKIPTDKLVEHLVDIAKKENIEHDEESLKLIAENSSGSMRNALFLLeQAAIYSNNKISEKSVRDLLGCVDKH 244

                        170
                 ....*....|....*..
gi 194306569 161 DIANILDWMLNQDFTTA 177
Cdd:PRK14964 245 ILEDLVEAILLGDAQSA 261
PRK14961 PRK14961
DNA polymerase III subunits gamma and tau; Provisional
 31-206 1.35e-15

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184925 [Multi-domain]  Cd Length: 363  Bit Score: 75.23  E-value: 1.35e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  31 KKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPLTPELMVPRLEHVVEEEKV 110
Cdd:PRK14961 117 KSRFKVYLIDEVHMLSRHSFNALLKTLEEPPQHIKFILATTDVEKIPKTILSRCLQFKLKIISEEKIFNFLKYILIKESI 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569 111 DISEDGMKALVTLSSGDMRRALNIL-QSTNMAFGKVTEETVYTCTGHPLKSDIANILDWMLNQDFTTAYRNITELKTLkG 189
Cdd:PRK14961 197 DTDEYALKLIAYHAHGSMRDALNLLeHAINLGKGNINIKNVTDMLGLLNEKQSFLLTDALLKKDSKKTMLLLNKISSI-G 275

                        170
                 ....*....|....*..
gi 194306569 190 LALHDILTEIHLFVHRV 206
Cdd:PRK14961 276 IEWENILIEMLRFLHHI 292
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 2-181 1.73e-15

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 75.62  E-value: 1.73e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   2 VLELNASDDRGIDIIRGPILSFASTRTIFKKgfKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQ 81
Cdd:PRK14950  91 VIEMDAASHTSVDDAREIIERVQFRPALARY--KVYIIDEVHMLSTAAFNALLKTLEEPPPHAIFILATTEVHKVPATIL 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  82 SRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTnMAF--GKVTEETVYTCTGHPLK 159
Cdd:PRK14950 169 SRCQRFDFHRHSVADMAAHLRKIAAAEGINLEPGALEAIARAATGSMRDAENLLQQL-ATTygGEISLSQVQSLLGISGD 247

                        170       180
                 ....*....|....*....|..
gi 194306569 160 SDIANILDWMLNQDFTTAYRNI 181
Cdd:PRK14950 248 EEVKALAEALLAKDLKAALRTL 269
PRK14963 PRK14963
DNA polymerase III subunits gamma and tau; Provisional
 2-157 5.25e-15

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184927 [Multi-domain]  Cd Length: 504  Bit Score: 74.11  E-value: 5.25e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   2 VLELNASDDRGIDIIRG--PILSFASTRTifkkGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPA 79
Cdd:PRK14963  87 VLEIDAASNNSVEDVRDlrEKVLLAPLRG----GRKVYILDEAHMMSKSAFNALLKTLEEPPEHVIFILATTEPEKMPPT 162

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194306569  80 LQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTNMAFGKVTEETVYTCTGHP 157
Cdd:PRK14963 163 ILSRTQHFRFRRLTEEEIAGKLRRLLEAEGREAEPEALQLVARLADGAMRDAESLLERLLALGTPVTRKQVEEALGLP 240
PRK07471 PRK07471
DNA polymerase III subunit delta'; Validated
 13-135 1.54e-14

DNA polymerase III subunit delta'; Validated


Pssm-ID: 236022 [Multi-domain]  Cd Length: 365  Bit Score: 71.98  E-value: 1.54e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  13 IDIIRGPILSFASTRTIfkKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPL 92
Cdd:PRK07471 123 VDEVRELISFFGLTAAE--GGWRVVIVDTADEMNANAANALLKVLEEPPARSLFLLVSHAPARLLPTIRSRCRKLRLRPL 200

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 194306569  93 TPELMVPRLehvvEEEKVDISEDGMKALVTLSSGDMRRALNIL 135
Cdd:PRK07471 201 APEDVIDAL----AAAGPDLPDDPRAALAALAEGSVGRALRLA 239
holB TIGR00678
DNA polymerase III, delta' subunit; This model describes the N-terminal half of the delta' ...
 12-103 5.51e-14

DNA polymerase III, delta' subunit; This model describes the N-terminal half of the delta' subunit of DNA polymerase III. Delta' is homologous to the gamma and tau subunits, which form an outgroup for phylogenetic comparison. The gamma/tau branch of the tree is much more tighly conserved than the delta' branch, and some members of that branch score more highly against this model than some proteins classisified as delta'. The noise cutoff is set to detect weakly scoring delta' subunits rather than to exclude gamma/tau subunits. At position 126-127 of the seed alignment, this family lacks the HM motif of gamma/tau; at 132 it has a near-invariant A vs. an invariant F in gamma/tau. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273213 [Multi-domain]  Cd Length: 188  Bit Score: 68.04  E-value: 5.51e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   12 GIDIIRGpILSFASTRTIfKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGP 91
Cdd:TIGR00678  77 KVDQVRE-LVEFLSRTPQ-ESGRRVVIIEDAERMNEAAANALLKTLEEPPPNTLFILITPSPEKLLPTIRSRCQRLPFPP 154

                          90
                  ....*....|..
gi 194306569   92 LTPELMVPRLEH 103
Cdd:TIGR00678 155 LSEEALLQWLIR 166
PRK05563 PRK05563
DNA polymerase III subunits gamma and tau; Validated
 2-184 1.22e-13

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 235505 [Multi-domain]  Cd Length: 559  Bit Score: 69.90  E-value: 1.22e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   2 VLELNASDDRGIDIIRgPILS---FASTRTIFKkgfklV-ILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKII 77
Cdd:PRK05563  90 VIEIDAASNNGVDEIR-DIRDkvkYAPSEAKYK-----VyIIDEVHMLSTGAFNALLKTLEEPPAHVIFILATTEPHKIP 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  78 PALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL-QSTNMAFGKVTEETVYTCTGH 156
Cdd:PRK05563 164 ATILSRCQRFDFKRISVEDIVERLKYILDKEGIEYEDEALRLIARAAEGGMRDALSILdQAISFGDGKVTYEDALEVTGS 243

                        170       180
                 ....*....|....*....|....*...
gi 194306569 157 PLKSDIANILDWMLNQDFTTAYRNITEL 184
Cdd:PRK05563 244 VSQEALDDLVDAIVEGDVAKALKILEEL 271
PRK09112 PRK09112
DNA polymerase III subunit delta'; Validated
 26-136 1.13e-12

DNA polymerase III subunit delta'; Validated


Pssm-ID: 169667 [Multi-domain]  Cd Length: 351  Bit Score: 66.60  E-value: 1.13e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  26 TRTIFKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPLTPELMVPRLEHVv 105
Cdd:PRK09112 134 SQTSGDGNWRIVIIDPADDMNRNAANAILKTLEEPPARALFILISHSSGRLLPTIRSRCQPISLKPLDDDELKKALSHL- 212

                         90       100       110
                 ....*....|....*....|....*....|.
gi 194306569 106 eEEKVDISEDGMKALVTLSSGDMRRALNILQ 136
Cdd:PRK09112 213 -GSSQGSDGEITEALLQRSKGSVRKALLLLN 242
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
3-150 1.59e-12

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 66.82  E-value: 1.59e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   3 LELNASDDRGIDIIrGPILSfastRTIFKKG---FKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPA 79
Cdd:PRK12323  96 IEMDAASNRGVDEM-AQLLD----KAVYAPTagrFKVYMIDEVHMLTNHAFNAMLKTLEEPPEHVKFILATTDPQKIPVT 170

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 194306569  80 LQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL-QSTNMAFGKVTEETV 150
Cdd:PRK12323 171 VLSRCLQFNLKQMPPGHIVSHLDAILGEEGIAHEVNALRLLAQAAQGSMRDALSLTdQAIAYSAGNVSEEAV 242
PRK13342 PRK13342
recombination factor protein RarA; Reviewed
 61-156 3.49e-12

recombination factor protein RarA; Reviewed


Pssm-ID: 237355 [Multi-domain]  Cd Length: 413  Bit Score: 65.49  E-value: 3.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  61 TENTRFclicnylsKIIPALQSRCTRFRFGPLTPELMVPRLEHVVEEEK---VDISEDGMKALVTLSSGDMRRALNILQS 137
Cdd:PRK13342 128 TENPSF--------EVNPALLSRAQVFELKPLSEEDIEQLLKRALEDKErglVELDDEALDALARLANGDARRALNLLEL 199

                         90
                 ....*....|....*....
gi 194306569 138 TNMAFGKVTEETVYTCTGH 156
Cdd:PRK13342 200 AALGVDSITLELLEEALQK 218
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 2-155 9.21e-12

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 64.38  E-value: 9.21e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   2 VLELNASDDRGIDIIRGpiLSFASTRTIFKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQ 81
Cdd:PRK14965  90 VFEIDGASNTGVDDIRE--LRENVKYLPSRSRYKIFIIDEVHMLSTNAFNALLKTLEEPPPHVKFIFATTEPHKVPITIL 167

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194306569  82 SRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTNMAFGK-VTEETVYTCTG 155
Cdd:PRK14965 168 SRCQRFDFRRIPLQKIVDRLRYIADQEGISISDAALALVARKGDGSMRDSLSTLDQVLAFCGDaVGDDDVAELLG 242
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 4-206 2.37e-11

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 63.19  E-value: 2.37e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   4 ELNASDDRGIDIIRGpILSFAstrtIFK--KG-FKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPAL 80
Cdd:PRK14951  97 ELDAASNRGVDEVQQ-LLEQA----VYKpvQGrFKVFMIDEVHMLTNTAFNAMLKTLEEPPEYLKFVLATTDPQKVPVTV 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  81 QSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL-QSTNMAFGKVTEETVYTCTGHPLK 159
Cdd:PRK14951 172 LSRCLQFNLRPMAPETVLEHLTQVLAAENVPAEPQALRLLARAARGSMRDALSLTdQAIAFGSGQLQEAAVRQMLGSVDR 251

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 194306569 160 SDIANILDWMLNQDFTTAYRNITELKTlKGLALHDILTEIHLFVHRV 206
Cdd:PRK14951 252 SHVFRLIDALAQGDGRTVVETADELRL-NGLSAASTLEEMAAVLQRM 297
PRK14969 PRK14969
DNA polymerase III subunits gamma and tau; Provisional
 3-173 3.37e-11

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237873 [Multi-domain]  Cd Length: 527  Bit Score: 62.84  E-value: 3.37e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   3 LELNASDDRGIDIIRgPILS---FASTRTifkkGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPA 79
Cdd:PRK14969  91 IEVDAASNTQVDAMR-ELLDnaqYAPTRG----RFKVYIIDEVHMLSKSAFNAMLKTLEEPPEHVKFILATTDPQKIPVT 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  80 LQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTnMAFG--KVTEETVYTCTGHP 157
Cdd:PRK14969 166 VLSRCLQFNLKQMPPPLIVSHLQHILEQENIPFDATALQLLARAAAGSMRDALSLLDQA-IAYGggTVNESEVRAMLGAI 244

                        170
                 ....*....|....*.
gi 194306569 158 LKSDIANILDWMLNQD 173
Cdd:PRK14969 245 DQDYLFALLEALLAQD 260
PRK06305 PRK06305
DNA polymerase III subunits gamma and tau; Validated
 2-152 5.92e-11

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 180523 [Multi-domain]  Cd Length: 451  Bit Score: 61.71  E-value: 5.92e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   2 VLELNASDDRGIDIIR--GPILSFASTrtifKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPA 79
Cdd:PRK06305  92 VLEIDGASHRGIEDIRqiNETVLFTPS----KSRYKIYIIDEVHMLTKEAFNSLLKTLEEPPQHVKFFLATTEIHKIPGT 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  80 LQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL-------------QSTNMAFGKVT 146
Cdd:PRK06305 168 ILSRCQKMHLKRIPEETIIDKLALIAKQEGIETSREALLPIARAAQGSLRDAESLYdyvvglfpksldpDSVAKALGLLS 247


                 ....*.
gi 194306569 147 EETVYT 152
Cdd:PRK06305 248 QDSLYT 253
PRK05564 PRK05564
DNA polymerase III subunit delta'; Validated
 12-126 2.74e-10

DNA polymerase III subunit delta'; Validated


Pssm-ID: 180132 [Multi-domain]  Cd Length: 313  Bit Score: 59.28  E-value: 2.74e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  12 GIDIIRGPIlsfastRTIFKKGF----KLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRF 87
Cdd:PRK05564  74 GVDDIRNII------EEVNKKPYegdkKVIIIYNSEKMTEQAQNAFLKTIEEPPKGVFIILLCENLEQILDTIKSRCQIY 147

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 194306569  88 RFGPLTPELMvprlEHVVEEEKVDISEDGMKALVTLSSG 126
Cdd:PRK05564 148 KLNRLSKEEI----EKFISYKYNDIKEEEKKSAIAFSDG 182
PRK05707 PRK05707
DNA polymerase III subunit delta'; Validated
 13-209 4.99e-10

DNA polymerase III subunit delta'; Validated


Pssm-ID: 180215 [Multi-domain]  Cd Length: 328  Bit Score: 58.95  E-value: 4.99e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  13 IDIIRgPILSFAsTRTIFKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPL 92
Cdd:PRK05707  88 VDQVR-ELVSFV-VQTAQLGGRKVVLIEPAEAMNRNAANALLKSLEEPSGDTVLLLISHQPSRLLPTIKSRCQQQACPLP 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  93 TPELMVPRLEHVVEEEkvdiSEDGMKALVTLSSGDMRRALNiLQSTNMAF---------GKVTE------ETVYTCTGHP 157
Cdd:PRK05707 166 SNEESLQWLQQALPES----DERERIELLTLAGGSPLRALQ-LHEQGVREqrarvldgvKKLLKqqqsasQLAESWLKVP 240

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 194306569 158 LKSDIANILDW---MLNQDFTTAYRnitelktlkGLALHDILTEIHLFVHRVDFP 209
Cdd:PRK05707 241 LLLLFDWFCDWahdILRYQLTQDEE---------GLGLADMRKVLQYLAQKSPQA 286
PRK14952 PRK14952
DNA polymerase III subunits gamma/tau;
2-135 7.61e-10

DNA polymerase III subunits gamma/tau;


Pssm-ID: 237866 [Multi-domain]  Cd Length: 584  Bit Score: 58.74  E-value: 7.61e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   2 VLELNASDDRGIDIIRG----PILSFASTRtifkkgFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKII 77
Cdd:PRK14952  89 VVELDAASHGGVDDTRElrdrAFYAPAQSR------YRIFIVDEAHMVTTAGFNALLKIVEEPPEHLIFIFATTEPEKVL 162

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 194306569  78 PALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDIsEDGMKALVTLS-SGDMRRALNIL 135
Cdd:PRK14952 163 PTIRSRTHHYPFRLLPPRTMRALIARICEQEGVVV-DDAVYPLVIRAgGGSPRDTLSVL 220
HLD_clamp cd18133
helical lid domain of clamp loader-like AAA+ proteins; Clamp loader complexes are multisubunit ...
 95-154 1.18e-09

helical lid domain of clamp loader-like AAA+ proteins; Clamp loader complexes are multisubunit complexes that play an important role in DNA replication. They open sliding clamps for assembly and close them around DNA, specifically targeting them to sites where DNA synthesis is initiated and orienting them correctly for replication. The subunits belong to the clamp loader clade of AAA+ superfamily.


Pssm-ID: 350838 [Multi-domain]  Cd Length: 65  Bit Score: 53.24  E-value: 1.18e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 194306569  95 ELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTNMAF--GKVTEETVYTCT 154
Cdd:cd18133    4 EQLKRRLAAIAEQEKLKLDDAALQALAYISEGDLRKALNALQRAAALGddGKISLDRVYQAV 65
PRK14970 PRK14970
DNA polymerase III subunits gamma and tau; Provisional
 2-166 1.36e-09

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184934 [Multi-domain]  Cd Length: 367  Bit Score: 57.58  E-value: 1.36e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   2 VLELNASDDRGIDIIRGPIlsfASTRTIFKKG-FKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPAL 80
Cdd:PRK14970  79 IFELDAASNNSVDDIRNLI---DQVRIPPQTGkYKIYIIDEVHMLSSAAFNAFLKTLEEPPAHAIFILATTEKHKIIPTI 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  81 QSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQ------STNMAFGKVTE------- 147
Cdd:PRK14970 156 LSRCQIFDFKRITIKDIKEHLAGIAVKEGIKFEDDALHIIAQKADGALRDALSIFDrvvtfcGKNITRQAVTEnlnildy 235

                        170
                 ....*....|....*....
gi 194306569 148 ETVYTCTGHPLKSDIANIL 166
Cdd:PRK14970 236 DTYINVTDLILENKIPELL 254
DNA_pol3_delta2 pfam13177
DNA polymerase III, delta subunit; DNA polymerase III, delta subunit (EC 2.7.7.7) is required ...
 12-93 2.82e-09

DNA polymerase III, delta subunit; DNA polymerase III, delta subunit (EC 2.7.7.7) is required for, along with delta' subunit, the assembly of the processivity factor beta(2) onto primed DNA in the DNA polymerase III holoenzyme-catalyzed reaction. The delta subunit is also known as HolA.


Pssm-ID: 433013 [Multi-domain]  Cd Length: 161  Bit Score: 54.52  E-value: 2.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   12 GIDIIRGpILSFASTRTIFKKgFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGP 91
Cdd:pfam13177  82 KIDQIRE-LQKEFSKSPYEGK-KKVYIIEDAEKMTASAANSLLKFLEEPPGNTVIILLTENPSRLLPTIRSRCQIIRFKP 159


                  ..
gi 194306569   92 LT 93
Cdd:pfam13177 160 LS 161
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 2-91 1.24e-08

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 52.53  E-value: 1.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   2 VLELNASDDRGIDIIRGPILSFASTRTIFKK---GFKLVILDEADAMTQDAQNALRRVIEKF------TENTRFCLICNY 72
Cdd:cd00009   50 FLYLNASDLLEGLVVAELFGHFLVRLLFELAekaKPGVLFIDEIDSLSRGAQNALLRVLETLndlridRENVRVIGATNR 129

                         90       100
                 ....*....|....*....|..
gi 194306569  73 --LSKIIPALQSRC-TRFRFGP 91
Cdd:cd00009  130 plLGDLDRALYDRLdIRIVIPL 151
PRK08451 PRK08451
DNA polymerase III subunits gamma and tau; Validated
 2-184 1.56e-08

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236267 [Multi-domain]  Cd Length: 535  Bit Score: 54.65  E-value: 1.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   2 VLELNASDDRGIDIIRGPIL------SFAStrtifkkgFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSK 75
Cdd:PRK08451  88 IIEMDAASNRGIDDIRELIEqtkykpSMAR--------FKIFIIDEVHMLTKEAFNALLKTLEEPPSYVKFILATTDPLK 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  76 IIPALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL-QSTNMAFGKVTEETVYTCT 154
Cdd:PRK08451 160 LPATILSRTQHFRFKQIPQNSIISHLKTILEKEGVSYEPEALEILARSGNGSLRDTLTLLdQAIIYCKNAITESKVADML 239

                        170       180       190
                 ....*....|....*....|....*....|
gi 194306569 155 GHPLKSDIANILDWMLNQDFTTAYRNITEL 184
Cdd:PRK08451 240 GLLDPSKLEDFFQAILNQDKEKLFELLKEL 269
PRK14958 PRK14958
DNA polymerase III subunits gamma and tau; Provisional
 31-167 1.73e-08

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184922 [Multi-domain]  Cd Length: 509  Bit Score: 54.74  E-value: 1.73e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  31 KKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPLTPELMVPRLEHVVEEEKV 110
Cdd:PRK14958 117 KGRFKVYLIDEVHMLSGHSFNALLKTLEEPPSHVKFILATTDHHKLPVTVLSRCLQFHLAQLPPLQIAAHCQHLLKEENV 196

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 194306569 111 DISEDGMKALVTLSSGDMRRALNILQSTnMAFGkvteetvytcTGHPLKSDIANILD 167
Cdd:PRK14958 197 EFENAALDLLARAANGSVRDALSLLDQS-IAYG----------NGKVLIADVKTMLG 242
PRK07399 PRK07399
DNA polymerase III subunit delta'; Validated
 13-137 5.77e-08

DNA polymerase III subunit delta'; Validated


Pssm-ID: 236011 [Multi-domain]  Cd Length: 314  Bit Score: 52.60  E-value: 5.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  13 IDIIRGpILSFASTRTIFKKGfKLVILDEADAMTQDAQNALRRVIEKfTENTRFCLICNYLSKIIPALQSRCTRFRFGPL 92
Cdd:PRK07399 106 LEQIRE-IKRFLSRPPLEAPR-KVVVIEDAETMNEAAANALLKTLEE-PGNGTLILIAPSPESLLPTIVSRCQIIPFYRL 182

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 194306569  93 TPELMVPRLEHVVEEEKVDISedgMKALVTLSSGDMRRAL---NILQS 137
Cdd:PRK07399 183 SDEQLEQVLKRLGDEEILNIN---FPELLALAQGSPGAAIaniEQLQS 227
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 2-135 6.14e-08

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 53.15  E-value: 6.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   2 VLELNASDDRGIDIIRGpiLSFASTRTIFKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQ 81
Cdd:PRK14959  90 VVEIDGASNRGIDDAKR--LKEAIGYAPMEGRYKVFIIDEAHMLTREAFNALLKTLEEPPARVTFVLATTEPHKFPVTIV 167

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 194306569  82 SRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL 135
Cdd:PRK14959 168 SRCQHFTFTRLSEAGLEAHLTKVLGREGVDYDPAAVRLIARRAAGSVRDSMSLL 221
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
3-212 7.76e-08

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 52.93  E-value: 7.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   3 LELNASDDRGIDIIrGPILSFASTRTIFKKgFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQS 82
Cdd:PRK07003  91 VEMDAASNRGVDEM-AALLERAVYAPVDAR-FKVYMIDEVHMLTNHAFNAMLKTLEEPPPHVKFILATTDPQKIPVTVLS 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  83 RCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL-QSTNMAFGKVTEETVYTCTGHPLKSD 161
Cdd:PRK07003 169 RCLQFNLKQMPAGHIVSHLERILGEERIAFEPQALRLLARAAQGSMRDALSLTdQAIAYSANEVTETAVSGMLGALDQTY 248

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 194306569 162 IANILDWMLNQDfTTAYRNITELKTLKGLALHDILTEIHLFVHRVDF----PSSV 212
Cdd:PRK07003 249 MVRLLDALAAGD-GPEILAVADEMALRSLSFSTALQDLASLLHRIAWaqfaPASV 302
PRK14955 PRK14955
DNA polymerase III subunits gamma and tau; Provisional
 4-135 1.27e-07

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184919 [Multi-domain]  Cd Length: 397  Bit Score: 51.82  E-value: 1.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   4 ELNASDDRGIDIIRgpiLSFASTRTIFKKG-FKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQS 82
Cdd:PRK14955 100 EFDAASNNSVDDIR---LLRENVRYGPQKGrYRVYIIDEVHMLSIAAFNAFLKTLEEPPPHAIFIFATTELHKIPATIAS 176

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 194306569  83 RCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL 135
Cdd:PRK14955 177 RCQRFNFKRIPLEEIQQQLQGICEAEGISVDADALQLIGRKAQGSMRDAQSIL 229
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
4-168 1.50e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 51.70  E-value: 1.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   4 ELNASDDRGIDIIRGPILSFASTRTIFKkgFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSR 83
Cdd:PRK14971  94 ELDAASNNSVDDIRNLIEQVRIPPQIGK--YKIYIIDEVHMLSQAAFNAFLKTLEEPPSYAIFILATTEKHKILPTILSR 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  84 CTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL-QSTNMAFGKVTEETVYtctghplksDI 162
Cdd:PRK14971 172 CQIFDFNRIQVADIVNHLQYVASKEGITAEPEALNVIAQKADGGMRDALSIFdQVVSFTGGNITYKSVI---------EN 242


                 ....*.
gi 194306569 163 ANILDW 168
Cdd:PRK14971 243 LNILDY 248
PRK13341 PRK13341
AAA family ATPase;
61-136 1.69e-07

AAA family ATPase;


Pssm-ID: 237354 [Multi-domain]  Cd Length: 725  Bit Score: 51.59  E-value: 1.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  61 TENTRFclicnylsKIIPALQSRCTRFRFGPLTPELMVPRLEHVVEEE-------KVDISEDGMKALVTLSSGDMRRALN 133
Cdd:PRK13341 145 TENPYF--------EVNKALVSRSRLFRLKSLSDEDLHQLLKRALQDKergygdrKVDLEPEAEKHLVDVANGDARSLLN 216


                 ...
gi 194306569 134 ILQ 136
Cdd:PRK13341 217 ALE 219
PRK06090 PRK06090
DNA polymerase III subunit delta'; Validated
 33-98 1.75e-07

DNA polymerase III subunit delta'; Validated


Pssm-ID: 180394 [Multi-domain]  Cd Length: 319  Bit Score: 50.96  E-value: 1.75e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194306569  33 GFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPLTPELMV 98
Cdd:PRK06090 108 GYRLFVIEPADAMNESASNALLKTLEEPAPNCLFLLVTHNQKRLLPTIVSRCQQWVVTPPSTAQAM 173
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 4-147 2.11e-07

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 51.48  E-value: 2.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   4 ELNASDDRGIDIIRgpiLSFASTRTIFKKG-FKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQS 82
Cdd:PRK14954 100 EFDAASNNSVDDIR---QLRENVRYGPQKGrYRVYIIDEVHMLSTAAFNAFLKTLEEPPPHAIFIFATTELHKIPATIAS 176

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194306569  83 RCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTnMAFGKVTE 147
Cdd:PRK14954 177 RCQRFNFKRIPLDEIQSQLQMICRAEGIQIDADALQLIARKAQGSMRDAQSILDQV-IAFSVGSE 240
PRK06645 PRK06645
DNA polymerase III subunits gamma and tau; Validated
 2-141 3.03e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 180643 [Multi-domain]  Cd Length: 507  Bit Score: 50.63  E-value: 3.03e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   2 VLELNASDDRGIDIIRgPILSFASTRTIFKKgFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQ 81
Cdd:PRK06645  99 IIEIDAASKTSVDDIR-RIIESAEYKPLQGK-HKIFIIDEVHMLSKGAFNALLKTLEEPPPHIIFIFATTEVQKIPATII 176

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 194306569  82 SRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL-QSTNMA 141
Cdd:PRK06645 177 SRCQRYDLRRLSFEEIFKLLEYITKQENLKTDIEALRIIAYKSEGSARDAVSILdQAASMS 237
HLD_clamp_pol_III_gamma_tau cd18137
helical lid domain of DNA polymerase III subunits gamma and tau; DNA polymerase III subunit ...
 92-155 4.09e-07

helical lid domain of DNA polymerase III subunits gamma and tau; DNA polymerase III subunit gamma/tau is part of the DNA polymerase III holoenzyme. Gamma and tau subunits are isoforms, both containing the helical lid domain. Gamma interacts with the delta subunit to transfer the beta subunit on the DNA while tau serves as a scaffold to help in the dimerization of the core complex. Both are members of the clamp-loader clade of the AAA+ superfamily.


Pssm-ID: 350839 [Multi-domain]  Cd Length: 65  Bit Score: 45.96  E-value: 4.09e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194306569  92 LTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL-QSTNMAFGKVTEETVYTCTG 155
Cdd:cd18137    1 ISVEDIVGRLAHILEKEGIEIEDEALELIARAAEGSMRDALSLLdQAIAFGGGRVTLDDVREMLG 65
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 2-92 5.30e-07

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 47.59  E-value: 5.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569    2 VLELNASDDRGIDIIRGPilsfASTRTIFKKGFKL----VILDEADAM-----------TQDAQNALRRVIEKFT---EN 63
Cdd:pfam00004  26 FIEISGSELVSKYVGESE----KRLRELFEAAKKLapcvIFIDEIDALagsrgsggdseSRRVVNQLLTELDGFTssnSK 101

                          90       100
                  ....*....|....*....|....*....
gi 194306569   64 TRFCLICNYLSKIIPALQSRCTRFRFGPL 92
Cdd:pfam00004 102 VIVIAATNRPDKLDPALLGRFDRIIEFPL 130
PRK14960 PRK14960
DNA polymerase III subunit gamma/tau;
34-144 1.01e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237868 [Multi-domain]  Cd Length: 702  Bit Score: 49.28  E-value: 1.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  34 FKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDIS 113
Cdd:PRK14960 119 FKVYLIDEVHMLSTHSFNALLKTLEEPPEHVKFLFATTDPQKLPITVISRCLQFTLRPLAVDEITKHLGAILEKEQIAAD 198

                         90       100       110
                 ....*....|....*....|....*....|.
gi 194306569 114 EDGMKALVTLSSGDMRRALNiLQSTNMAFGK 144
Cdd:PRK14960 199 QDAIWQIAESAQGSLRDALS-LTDQAIAYGQ 228
PRK14957 PRK14957
DNA polymerase III subunits gamma and tau; Provisional
 34-238 1.44e-06

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184921 [Multi-domain]  Cd Length: 546  Bit Score: 48.92  E-value: 1.44e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  34 FKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDIS 113
Cdd:PRK14957 120 YKVYLIDEVHMLSKQSFNALLKTLEEPPEYVKFILATTDYHKIPVTILSRCIQLHLKHISQADIKDQLKIILAKENINSD 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569 114 EDGMKALVTLSSGDMRRALNIL-QSTNMAFGKVTEETVYTCTGHPLKSDIANILDWMLNQD---FTTAYRNITeLKTLKG 189
Cdd:PRK14957 200 EQSLEYIAYHAKGSLRDALSLLdQAISFCGGELKQAQIKQMLGIIDSEEVYSIINAIIDNDpkaILPAIKNLA-LTESSA 278

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194306569 190 LALHDILTE------IHLFVHRVDFPSSVRIHLLTKMAD---IE-----YRLSVGTNEKIQLS 238
Cdd:PRK14957 279 DAVLDRIAEiwfaccIYSFTQSLDAVNDIDVDIINNILAkisIEqahflYQLTITAKKDIALA 341
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 2-135 4.49e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 47.29  E-value: 4.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   2 VLELNASDDRGIDIIR--------GPilsfASTRtifkkgFKLVILDEADAMTQDAQNALRRVIE------KF----TEN 63
Cdd:PRK07764  91 VTEIDAASHGGVDDARelreraffAP----AESR------YKIFIIDEAHMVTPQGFNALLKIVEeppehlKFifatTEP 160

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194306569  64 trfclicnylSKIIPALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDIsEDGMKALVTLS-SGDMRRALNIL 135
Cdd:PRK07764 161 ----------DKVIGTIRSRTHHYPFRLVPPEVMRGYLERICAQEGVPV-EPGVLPLVIRAgGGSVRDSLSVL 222
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 82-150 5.13e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 47.17  E-value: 5.13e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194306569  82 SRCTRFRFGPLTPELMVPRLEHVVEEEKVDiSEDgmKALVTLS---SGDMRRALNIL-QSTNMAFGKVTEETV 150
Cdd:PRK07994 168 SRCLQFHLKALDVEQIRQQLEHILQAEQIP-FEP--RALQLLAraaDGSMRDALSLTdQAIASGNGQVTTDDV 237
PRK07993 PRK07993
DNA polymerase III subunit delta'; Validated
 33-137 7.53e-06

DNA polymerase III subunit delta'; Validated


Pssm-ID: 181190 [Multi-domain]  Cd Length: 334  Bit Score: 46.21  E-value: 7.53e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  33 GFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPLTPELMVPRLEHvveeeKVDI 112
Cdd:PRK07993 108 GAKVVWLPDAALLTDAAANALLKTLEEPPENTWFFLACREPARLLATLRSRCRLHYLAPPPEQYALTWLSR-----EVTM 182

                         90       100
                 ....*....|....*....|....*
gi 194306569 113 SEDGMKALVTLSSGDMRRALNILQS 137
Cdd:PRK07993 183 SQDALLAALRLSAGAPGAALALLQP 207
PRK14956 PRK14956
DNA polymerase III subunits gamma and tau; Provisional
 2-136 1.06e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184920 [Multi-domain]  Cd Length: 484  Bit Score: 46.09  E-value: 1.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   2 VLELNASDDRGIDIIRG--PILSFAStrtiFKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPA 79
Cdd:PRK14956  92 VLEIDAASNRGIENIRElrDNVKFAP----MGGKYKVYIIDEVHMLTDQSFNALLKTLEEPPAHIVFILATTEFHKIPET 167

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 194306569  80 LQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQ 136
Cdd:PRK14956 168 ILSRCQDFIFKKVPLSVLQDYSEKLCKIENVQYDQEGLFWIAKKGDGSVRDMLSFME 224
PRK06964 PRK06964
DNA polymerase III subunit delta'; Validated
 13-102 1.35e-05

DNA polymerase III subunit delta'; Validated


Pssm-ID: 235898 [Multi-domain]  Cd Length: 342  Bit Score: 45.52  E-value: 1.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  13 IDIIRGpILSFASTRTiFKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPL 92
Cdd:PRK06964 114 IEQVRA-LLDFCGVGT-HRGGARVVVLYPAEALNVAAANALLKTLEEPPPGTVFLLVSARIDRLLPTILSRCRQFPMTVP 191

                         90
                 ....*....|
gi 194306569  93 TPELMVPRLE 102
Cdd:PRK06964 192 APEAAAAWLA 201
AAA_assoc_2 pfam16193
AAA C-terminal domain; AAA_assoc_2 is found at the C-terminus of a relatively small set of AAA ...
 106-150 1.56e-05

AAA C-terminal domain; AAA_assoc_2 is found at the C-terminus of a relatively small set of AAA domains in proteins ranging from archaeal to fungi, plants and mammals.


Pssm-ID: 465057  Cd Length: 81  Bit Score: 42.07  E-value: 1.56e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 194306569  106 EEEKVDISEDGMKALVTLSSGDMRRALNIL----QSTNMAFGK--VTEETV 150
Cdd:pfam16193   1 GGLKIELDDEALEALAELADGDARRALNALelavLSTPPDDGGihITLEIL 51
PRK09111 PRK09111
DNA polymerase III subunits gamma and tau; Validated
 2-150 1.85e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236382 [Multi-domain]  Cd Length: 598  Bit Score: 45.28  E-value: 1.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   2 VLELNASDDRGIDIIRGPILSF----ASTRtifkkgFKLVILDEADAMTQDAQNALRRVIE------KF----TEntrfc 67
Cdd:PRK09111 103 VLEMDAASHTGVDDIREIIESVryrpVSAR------YKVYIIDEVHMLSTAAFNALLKTLEeppphvKFifatTE----- 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  68 licnyLSKI-IPALqSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL-QSTNMAFGKV 145
Cdd:PRK09111 172 -----IRKVpVTVL-SRCQRFDLRRIEADVLAAHLSRIAAKEGVEVEDEALALIARAAEGSVRDGLSLLdQAIAHGAGEV 245


                 ....*
gi 194306569 146 TEETV 150
Cdd:PRK09111 246 TAEAV 250
PRK08699 PRK08699
DNA polymerase III subunit delta'; Validated
 13-87 3.70e-05

DNA polymerase III subunit delta'; Validated


Pssm-ID: 181538 [Multi-domain]  Cd Length: 325  Bit Score: 44.09  E-value: 3.70e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194306569  13 IDIIRgPILSFASTrTIFKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRF 87
Cdd:PRK08699  95 IDAVR-EIIDNVYL-TSVRGGLRVILIHPAESMNLQAANSLLKVLEEPPPQVVFLLVSHAADKVLPTIKSRCRKM 167
PRK06647 PRK06647
DNA polymerase III subunits gamma and tau; Validated
 34-131 8.27e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 235845 [Multi-domain]  Cd Length: 563  Bit Score: 43.22  E-value: 8.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  34 FKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDIS 113
Cdd:PRK06647 120 YRVYIIDEVHMLSNSAFNALLKTIEEPPPYIVFIFATTEVHKLPATIKSRCQHFNFRLLSLEKIYNMLKKVCLEDQIKYE 199

                         90
                 ....*....|....*...
gi 194306569 114 EDGMKALVTLSSGDMRRA 131
Cdd:PRK06647 200 DEALKWIAYKSTGSVRDA 217
HLD_clamp_RarA cd18139
helical lid domain of recombination factor protein RarA; Recombination factor RarA ...
 92-136 2.42e-04

helical lid domain of recombination factor protein RarA; Recombination factor RarA (Replication associated recombination gene/protein A, also known as MgsA (Maintenance of genome stability A) or Mgs1 in yeast and WRNIP1 in mammals) is a member of the clamp-loader clade of the AAA+ superfamily. It functions as a tetramer. RarA co-localize with the replication fork throughout the cell cycle and may play a role in the rescue of stalled replication forks.


Pssm-ID: 350841 [Multi-domain]  Cd Length: 75  Bit Score: 38.77  E-value: 2.42e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 194306569  92 LTPELMVPRLEHVVEEE------KVDISEDGMKALVTLSSGDMRRALNILQ 136
Cdd:cd18139    1 LSEEDLEKLLKRALEDKerggdrKVTIDDEALELLAEAADGDARSALNLLE 51
PRK14948 PRK14948
DNA polymerase III subunit gamma/tau;
2-150 2.99e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237862 [Multi-domain]  Cd Length: 620  Bit Score: 41.87  E-value: 2.99e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569   2 VLELNASDDRGIDIIRGPI--LSFAST--RtifkkgFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKII 77
Cdd:PRK14948  92 VIEIDAASNTGVDNIRELIerAQFAPVqaR------WKVYVIDECHMLSTAAFNALLKTLEEPPPRVVFVLATTDPQRVL 165

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194306569  78 PALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTNMAFGKVTEETV 150
Cdd:PRK14948 166 PTIISRCQRFDFRRIPLEAMVQHLSEIAEKESIEIEPEALTLVAQRSQGGLRDAESLLDQLSLLPGPITPEAV 238
PRK06871 PRK06871
DNA polymerase III subunit delta'; Validated
 10-84 1.33e-03

DNA polymerase III subunit delta'; Validated


Pssm-ID: 180738 [Multi-domain]  Cd Length: 325  Bit Score: 39.33  E-value: 1.33e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194306569  10 DRGIDIIR---GPILSFAStrtifKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRC 84
Cdd:PRK06871  86 DIGVDQVReinEKVSQHAQ-----QGGNKVVYIQGAERLTEAAANALLKTLEEPRPNTYFLLQADLSAALLPTIYSRC 158
PRK07132 PRK07132
DNA polymerase III subunit delta'; Validated
 35-89 2.19e-03

DNA polymerase III subunit delta'; Validated


Pssm-ID: 180855 [Multi-domain]  Cd Length: 299  Bit Score: 38.55  E-value: 2.19e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 194306569  35 KLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRF 89
Cdd:PRK07132  92 KILIIKNIEKTSNSLLNALLKTIEEPPKDTYFLLTTKNINKVLPTIVSRCQVFNV 146
PRK06581 PRK06581
DNA polymerase III subunit delta'; Validated
 8-84 4.27e-03

DNA polymerase III subunit delta'; Validated


Pssm-ID: 235833 [Multi-domain]  Cd Length: 263  Bit Score: 37.52  E-value: 4.27e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194306569   8 SDDRGIDIIRGPILSFASTRTIFKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRC 84
Cdd:PRK06581  64 SNAKNISIEQIRKLQDFLSKTSAISGYKVAIIYSAELMNLNAANSCLKILEDAPKNSYIFLITSRAASIISTIRSRC 140
PRK14949 PRK14949
DNA polymerase III subunits gamma and tau; Provisional
 34-143 4.94e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237863 [Multi-domain]  Cd Length: 944  Bit Score: 38.17  E-value: 4.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306569  34 FKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDIS 113
Cdd:PRK14949 120 FKVYLIDEVHMLSRSSFNALLKTLEEPPEHVKFLLATTDPQKLPVTVLSRCLQFNLKSLTQDEIGTQLNHILTQEQLPFE 199

                         90       100       110
                 ....*....|....*....|....*....|
gi 194306569 114 EDGMKALVTLSSGDMRRALNiLQSTNMAFG 143
Cdd:PRK14949 200 AEALTLLAKAANGSMRDALS-LTDQAIAFG 228
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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