|
Name |
Accession |
Description |
Interval |
E-value |
| rfc |
PRK00440 |
replication factor C small subunit; Reviewed |
2-308 |
3.07e-122 |
|
replication factor C small subunit; Reviewed
Pssm-ID: 234763 [Multi-domain] Cd Length: 319 Bit Score: 353.41 E-value: 3.07e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 2 VEKYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLYGPPGTGKTSTILACAKQLYKDKEFGSMvLELNASDDRGIDIIR 81
Cdd:PRK00440 8 VEKYRPRTLDEIVGQEEIVERLKSYVKEKNMPHLLFAGPPGTGKTTAALALARELYGEDWRENF-LELNASDERGIDVIR 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 82 GPILSFASTRTIFKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPLTPELM 161
Cdd:PRK00440 87 NKIKEFARTAPVGGAPFKIIFLDEADNLTSDAQQALRRTMEMYSQNTRFILSCNYSSKIIDPIQSRCAVFRFSPLKKEAV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 162 VPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTNMAFGKVTEETVYTCTGHPLKSDIANILDWMLNQDFTTA 241
Cdd:PRK00440 167 AERLRYIAENEGIEITDDALEAIYYVSEGDMRKAINALQAAAATGKEVTEEAVYKITGTARPEEIREMIELALNGDFTEA 246
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194306567 242 YRNITELKTLKGLALHDILTEIHLFVHRVDFPSSVRIHLLTKMADIEYRLSVGTNEKIQLSSLIAAF 308
Cdd:PRK00440 247 REKLRDLMIDYGLSGEDIIKQIHREVWSLDIPEELKVELIDAIGEADFRITEGANERIQLEALLAKL 313
|
|
| PLN03025 |
PLN03025 |
replication factor C subunit; Provisional |
2-313 |
4.49e-84 |
|
replication factor C subunit; Provisional
Pssm-ID: 178596 [Multi-domain] Cd Length: 319 Bit Score: 256.19 E-value: 4.49e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 2 VEKYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLYGPPGTGKTSTILACAKQL----YKDKefgsmVLELNASDDRGI 77
Cdd:PLN03025 4 VEKYRPTKLDDIVGNEDAVSRLQVIARDGNMPNLILSGPPGTGKTTSILALAHELlgpnYKEA-----VLELNASDDRGI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 78 DIIRGPILSFASTRTIFKKG-FKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPL 156
Cdd:PLN03025 79 DVVRNKIKMFAQKKVTLPPGrHKIVILDEADSMTSGAQQALRRTMEIYSNTTRFALACNTSSKIIEPIQSRCAIVRFSRL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 157 TPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTNMAFGKVTEETVYTCTGHPLKSDIANILDWMLNQ 236
Cdd:PLN03025 159 SDQEILGRLMKVVEAEKVPYVPEGLEAIIFTADGDMRQALNNLQATHSGFGFVNQENVFKVCDQPHPLHVKNIVRNCLKG 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194306567 237 DFTTAYRNITELKTLkGLALHDILTEIHLFVHRVDFPSSVRIHLLTKMADIEYRLSVGTNEKIQLSSLIAAFQVTRD 313
Cdd:PLN03025 239 KFDDACDGLKQLYDL-GYSPTDIITTLFRVVKNYDMPEFLKLEYLREIGFAHMRICDGVGSLLQLSGLLAKLCLVRE 314
|
|
| PRK12402 |
PRK12402 |
replication factor C small subunit 2; Reviewed |
3-308 |
1.65e-71 |
|
replication factor C small subunit 2; Reviewed
Pssm-ID: 237090 [Multi-domain] Cd Length: 337 Bit Score: 224.87 E-value: 1.65e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 3 EKYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLYGPPGTGKTSTILACAKQLYKDKeFGSMVLELNAS---------- 72
Cdd:PRK12402 7 EKYRPALLEDILGQDEVVERLSRAVDSPNLPHLLVQGPPGSGKTAAVRALARELYGDP-WENNFTEFNVAdffdqgkkyl 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 73 --DDRGIDIIRGPILSFASTRTIFKK-------------GFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYL 137
Cdd:PRK12402 86 veDPRFAHFLGTDKRIRSSKIDNFKHvlkeyasyrplsaDYKTILLDNAEALREDAQQALRRIMEQYSRTCRFIIATRQP 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 138 SKIIPALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTNMAFGKVTEETVYTC 217
Cdd:PRK12402 166 SKLIPPIRSRCLPLFFRAPTDDELVDVLESIAEAEGVDYDDDGLELIAYYAGGDLRKAILTLQTAALAAGEITMEAAYEA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 218 TGH-PLKSDIANILDWMLNQDFTTAYRNITELKTLKGLALHDILTEIHLFVHRVDFPSSV-RIHllTKMADIEYRLSVGT 295
Cdd:PRK12402 246 LGDvGTDEVIESLLDAAEAGDFTDARKTLDDLLIDEGLSGGEVLEELLRVARSRYRGDNLaRLH--RLAADADARLTDGA 323
|
330
....*....|...
gi 194306567 296 NEKIQLSSLIAAF 308
Cdd:PRK12402 324 NDRIQLEALLAEL 336
|
|
| PRK04132 |
PRK04132 |
replication factor C small subunit; Provisional |
46-308 |
8.13e-65 |
|
replication factor C small subunit; Provisional
Pssm-ID: 235223 [Multi-domain] Cd Length: 846 Bit Score: 218.56 E-value: 8.13e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 46 TSTILACAKQLYKDKeFGSMVLELNASDDRGIDIIRGPILSFASTRTIFKKGFKLVILDEADAMTQDAQNALRRVIEKFT 125
Cdd:PRK04132 580 TTAALALARELFGEN-WRHNFLELNASDERGINVIREKVKEFARTKPIGGASFKIIFLDEADALTQDAQQALRRTMEMFS 658
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 126 ENTRFCLICNYLSKIIPALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTNMA 205
Cdd:PRK04132 659 SNVRFILSCNYSSKIIEPIQSRCAIFRFRPLRDEDIAKRLRYIAENEGLELTEEGLQAILYIAEGDMRRAINILQAAAAL 738
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 206 FGKVTEETVYTCTGHPLKSDIANILDWMLNQDFTTAYRNITELKTLKGLALHDILTEIHLFVHRVDFPSSVRIHLLTKMA 285
Cdd:PRK04132 739 DDKITDENVFLVASRARPEDIREMMLLALKGNFLKAREKLREILLKQGLSGEDVLVQMHREVFNLPIDEPKKVELADKIG 818
|
250 260
....*....|....*....|...
gi 194306567 286 DIEYRLSVGTNEKIQLSSLIAAF 308
Cdd:PRK04132 819 EYNFRLVEGANEMIQLEALLAQF 841
|
|
| HolB |
COG0470 |
DNA polymerase III, delta prime subunit [Replication, recombination and repair]; |
16-309 |
4.55e-58 |
|
DNA polymerase III, delta prime subunit [Replication, recombination and repair];
Pssm-ID: 440238 [Multi-domain] Cd Length: 289 Bit Score: 188.65 E-value: 4.55e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 16 HQDILSTIQKFINEDRLPH-LLLYGPPGTGKTSTILACAKQLYKDKEFGSM-----------------VLELNA---SDD 74
Cdd:COG0470 1 QEEAWEQLLAAAESGRLPHaLLLHGPPGIGKTTLALALARDLLCENPEGGKacgqchsrlmaagnhpdLLELNPeekSDQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 75 RGIDIIRGpILSFASTRTIFKkGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFG 154
Cdd:COG0470 81 IGIDQIRE-LGEFLSLTPLEG-GRKVVIIDEADAMNEAAANALLKTLEEPPKNTPFILIANDPSRLLPTIRSRCQVIRFR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 155 PLTPELMVPRLehvvEEEKVDisEDGMKALVTLSSGDMRRALNILQStnMAFGKVTEETVYTCTGHP---------LKSD 225
Cdd:COG0470 159 PPSEEEALAWL----REEGVD--EDALEAILRLAGGDPRAAINLLQA--LAGRKELLEDLAALLSRDralelldalLKAE 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 226 IANILDWMLNQdfttayrnitelktlkglaLHDILteihlfvhRVDFPSSVRIHLLTKMADIEYRLSVGTNEKIQLSSLI 305
Cdd:COG0470 231 ALELLDWLLKW-------------------LLDNL--------PLEYAGEDLARAYEALSEADRRLGRYANDRLLLEALL 283
|
....
gi 194306567 306 AAFQ 309
Cdd:COG0470 284 AKLG 287
|
|
| 44 |
PHA02544 |
clamp loader, small subunit; Provisional |
2-240 |
2.27e-47 |
|
clamp loader, small subunit; Provisional
Pssm-ID: 222866 [Multi-domain] Cd Length: 316 Bit Score: 161.70 E-value: 2.27e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 2 VEKYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLYGP-PGTGKTSTILA-CAkqlykdkEFGSMVLELNASDDRgIDI 79
Cdd:PHA02544 12 EQKYRPSTIDECILPAADKETFKSIVKKGRIPNMLLHSPsPGTGKTTVAKAlCN-------EVGAEVLFVNGSDCR-IDF 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 80 IRGPILSFASTRTiFKKGFKLVILDEAD-AMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPLTP 158
Cdd:PHA02544 84 VRNRLTRFASTVS-LTGGGKVIIIDEFDrLGLADAQRHLRSFMEAYSKNCSFIITANNKNGIIEPLRSRCRVIDFGVPTK 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 159 E-------LMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQStNMAFGKVTEETVYTCTGhplkSDIANILD 231
Cdd:PHA02544 163 EeqiemmkQMIVRCKGILEAEGVEVDMKVLAALVKKNFPDFRRTINELQR-YASTGKIDAGILSEVTN----SDIDDVVE 237
|
....*....
gi 194306567 232 WMLNQDFTT 240
Cdd:PHA02544 238 ALKAKDFKA 246
|
|
| PRK04195 |
PRK04195 |
replication factor C large subunit; Provisional |
2-231 |
4.67e-41 |
|
replication factor C large subunit; Provisional
Pssm-ID: 235250 [Multi-domain] Cd Length: 482 Bit Score: 148.92 E-value: 4.67e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 2 VEKYRPQTLNDLISHQDILSTIQKFINE--DRLPH--LLLYGPPGTGKTSTILACAKqlykdkEFGSMVLELNASDDRGI 77
Cdd:PRK04195 5 VEKYRPKTLSDVVGNEKAKEQLREWIESwlKGKPKkaLLLYGPPGVGKTSLAHALAN------DYGWEVIELNASDQRTA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 78 DIIRGPILSFASTRTIFKKGFKLVILDEADAM--TQDAQNAlrRVIEKFTENTRFCLIC---NYLSKIIPALQSRCTRFR 152
Cdd:PRK04195 79 DVIERVAGEAATSGSLFGARRKLILLDEVDGIhgNEDRGGA--RAILELIKKAKQPIILtanDPYDPSLRELRNACLMIE 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194306567 153 FGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTNMAFGKVTEETVYTCTGHPLKSDIANILD 231
Cdd:PRK04195 157 FKRLSTRSIVPVLKRICRKEGIECDDEALKEIAERSGGDLRSAINDLQAIAEGYGKLTLEDVKTLGRRDREESIFDALD 235
|
|
| PRK14953 |
PRK14953 |
DNA polymerase III subunits gamma and tau; Provisional |
4-276 |
3.43e-34 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237867 [Multi-domain] Cd Length: 486 Bit Score: 130.33 E-value: 3.43e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 4 KYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLY-GPPGTGKTST--ILA----------------CAKQLYKDK-EFG 63
Cdd:PRK14953 9 KYRPKFFKEVIGQEIVVRILKNAVKLQRVSHAYIFaGPRGTGKTTIarILAkvlnclnpqegepcgkCENCVEIDKgSFP 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 64 SMVlELNASDDRGIDIIRGpiLSFASTRTIFKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPA 143
Cdd:PRK14953 89 DLI-EIDAASNRGIDDIRA--LRDAVSYTPIKGKYKVYIIDEAHMLTKEAFNALLKTLEEPPPRTIFILCTTEYDKIPPT 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 144 LQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL-QSTNMAFGKVTEETVYTCTGHPL 222
Cdd:PRK14953 166 ILSRCQRFIFSKPTKEQIKEYLKRICNEEKIEYEEKALDLLAQASEGGMRDAASLLdQASTYGEGKVTIKVVEEFLGIVS 245
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 223 KSDIANILDWMLNQDFTTAYRNITELKTlKGLALH----DILTEIH--LFVHRVDFPSSV 276
Cdd:PRK14953 246 QESVRKFLNLLLESDVDEAIKFLRTLEE-KGYNLNkfwkQLEEEIRniLLNKSLKNPEEV 304
|
|
| DnaX |
COG2812 |
DNA polymerase III, gamma/tau subunits [Replication, recombination and repair]; |
7-305 |
3.35e-32 |
|
DNA polymerase III, gamma/tau subunits [Replication, recombination and repair];
Pssm-ID: 442061 [Multi-domain] Cd Length: 340 Bit Score: 122.22 E-value: 3.35e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 7 PQTLNDLISHQDILSTIQKFINEDRLPH-LLLYGPPGTGKTST--ILA----CAKQLYKD-----------KEFGSM-VL 67
Cdd:COG2812 6 PQTFDDVVGQEHVVRTLKNALASGRLAHaYLFTGPRGVGKTTLarILAkalnCENGPTGEpcgecescraiAAGSHPdVI 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 68 EL--NASDdRGIDIIRGPI--LSFASTRTifkkGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPA 143
Cdd:COG2812 86 EIdaEASN-IGVDDIRELIekVSYAPVEG----RYKVYIIDEAHMLTTEAFNALLKTLEEPPPHVVFILATTEPQKLLPT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 144 LQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQStNMAFGKV-TEETVYTCTGHPL 222
Cdd:COG2812 161 ILSRCQRFDFRRLPPEEIAEHLAKIAEREGIEIEPEALALIARAADGSMRDALSLLDQ-AIAFGLLdRRELLLDLLEALL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 223 KSDIANILDW------------MLNQDFTTAYRNITELKTLKGLALH---DILTEIHLFVHRVDFPSSVRIhlLTKMADI 287
Cdd:COG2812 240 AGDVAALLALaeelakrgrdlkRFLDDLLSLLRDLLLLKLGPDAELLvneDERERLQELARRLSPERLLRA--IQILLEA 317
|
330
....*....|....*...
gi 194306567 288 EYRLSVGTNEKIQLSSLI 305
Cdd:COG2812 318 RRELERNVNPRLALEMLL 335
|
|
| Rep_fac_C |
pfam08542 |
Replication factor C C-terminal domain; This is the C-terminal domain of RFC (replication ... |
221-307 |
1.35e-30 |
|
Replication factor C C-terminal domain; This is the C-terminal domain of RFC (replication factor-C) protein of the clamp loader complex which binds to the DNA sliding clamp (proliferating cell nuclear antigen, PCNA). The five modules of RFC assemble into a right-handed spiral, which results in only three of the five RFC subunits (RFC-A, RFC-B and RFC-C) making contact with PCNA, leaving a wedge-shaped gap between RFC-E and the PCNA clamp-loader complex. The C-terminal is vital for the correct orientation of RFC-E with respect to RFC-A.
Pssm-ID: 462513 [Multi-domain] Cd Length: 87 Bit Score: 110.64 E-value: 1.35e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 221 PLKSDIANILDWMLNQDFTTAYRNITELKTLKGLALHDILTEIHLFVHRVDFPSSVRIHLLTKMADIEYRLSVGTNEKIQ 300
Cdd:pfam08542 1 PHPEDIEEILNSCLNGDFDEAYKKVRELLVEKGYSLQDIITQLHRVVKSLDLPEEVKLELLEKLGEIEYRLSEGASEKLQ 80
|
....*..
gi 194306567 301 LSSLIAA 307
Cdd:pfam08542 81 LSALLAA 87
|
|
| PRK13342 |
PRK13342 |
recombination factor protein RarA; Reviewed |
3-220 |
5.92e-30 |
|
recombination factor protein RarA; Reviewed
Pssm-ID: 237355 [Multi-domain] Cd Length: 413 Bit Score: 117.49 E-value: 5.92e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 3 EKYRPQTLNDLISHQDIL---STIQKFINEDRLPHLLLYGPPGTGKTSTILACAKQLykDKEFgsmvLELNASDDrGIDI 79
Cdd:PRK13342 4 ERMRPKTLDEVVGQEHLLgpgKPLRRMIEAGRLSSMILWGPPGTGKTTLARIIAGAT--DAPF----EALSAVTS-GVKD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 80 IRGpILSFASTRTIFKKGFkLVILDEADAMTQDAQNALRRVIEKF--------TENTRFclicnylsKIIPALQSRCTRF 151
Cdd:PRK13342 77 LRE-VIEEARQRRSAGRRT-ILFIDEIHRFNKAQQDALLPHVEDGtitligatTENPSF--------EVNPALLSRAQVF 146
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 194306567 152 RFGPLTPELMVPRLEHVVEEEK---VDISEDGMKALVTLSSGDMRRALNILQSTNMAFGKVTEETVYTCTGH 220
Cdd:PRK13342 147 ELKPLSEEDIEQLLKRALEDKErglVELDDEALDALARLANGDARRALNLLELAALGVDSITLELLEEALQK 218
|
|
| PRK07133 |
PRK07133 |
DNA polymerase III subunits gamma and tau; Validated |
4-249 |
4.48e-27 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 235943 [Multi-domain] Cd Length: 725 Bit Score: 111.45 E-value: 4.48e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 4 KYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLY-GPPGTGKTST--ILACA------KQLYK---------DKEFGsm 65
Cdd:PRK07133 11 KYRPKTFDDIVGQDHIVQTLKNIIKSNKISHAYLFsGPRGTGKTSVakIFANAlncshkTDLLEpcqecienvNNSLD-- 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 66 VLELNASDDRGIDIIRGPILSFASTRTIFKkgFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQ 145
Cdd:PRK07133 89 IIEMDAASNNGVDEIRELIENVKNLPTQSK--YKIYIIDEVHMLSKSAFNALLKTLEEPPKHVIFILATTEVHKIPLTIL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 146 SRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL-QSTNMAFGKVTEETVYTCTGHPLKS 224
Cdd:PRK07133 167 SRVQRFNFRRISEDEIVSRLEFILEKENISYEKNALKLIAKLSSGSLRDALSIAeQVSIFGNNKITLKNVEELFGLVSNE 246
|
250 260
....*....|....*....|....*
gi 194306567 225 DIANILDWMLNQDFTTAYRNITELK 249
Cdd:PRK07133 247 NLINLLNLLYSKDIKEVLNILNQIK 271
|
|
| PRK14950 |
PRK14950 |
DNA polymerase III subunits gamma and tau; Provisional |
4-245 |
1.20e-26 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237864 [Multi-domain] Cd Length: 585 Bit Score: 109.90 E-value: 1.20e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 4 KYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLY-GPPGTGKTST--ILA----CAKQLYKDKEFG--SM--------- 65
Cdd:PRK14950 9 KWRSQTFAELVGQEHVVQTLRNAIAEGRVAHAYLFtGPRGVGKTSTarILAkavnCTTNDPKGRPCGtcEMcraiaegsa 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 66 --VLELNASDDRGIDIIRGPILSFASTRTIFKKgfKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPA 143
Cdd:PRK14950 89 vdVIEMDAASHTSVDDAREIIERVQFRPALARY--KVYIIDEVHMLSTAAFNALLKTLEEPPPHAIFILATTEVHKVPAT 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 144 LQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTnMAF--GKVTEETVYTCTGHP 221
Cdd:PRK14950 167 ILSRCQRFDFHRHSVADMAAHLRKIAAAEGINLEPGALEAIARAATGSMRDAENLLQQL-ATTygGEISLSQVQSLLGIS 245
|
250 260
....*....|....*....|....
gi 194306567 222 LKSDIANILDWMLNQDFTTAYRNI 245
Cdd:PRK14950 246 GDEEVKALAEALLAKDLKAALRTL 269
|
|
| PRK14962 |
PRK14962 |
DNA polymerase III subunits gamma and tau; Provisional |
4-219 |
5.12e-26 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237869 [Multi-domain] Cd Length: 472 Bit Score: 107.16 E-value: 5.12e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 4 KYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLY-GPPGTGKTSTILACAKQLYKDKEFGSM----------------- 65
Cdd:PRK14962 7 KYRPKTFSEVVGQDHVKKLIINALKKNSISHAYIFaGPRGTGKTTVARILAKSLNCENRKGVEpcnecracrsidegtfm 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 66 -VLELNASDDRGIDIIRgPILSFASTRTIFKKgFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPAL 144
Cdd:PRK14962 87 dVIELDAASNRGIDEIR-KIRDAVGYRPMEGK-YKVYIIDEVHMLTKEAFNALLKTLEEPPSHVVFVLATTNLEKVPPTI 164
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194306567 145 QSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL-QSTNMAFGKVTEETVYTCTG 219
Cdd:PRK14962 165 ISRCQVIEFRNISDELIIKRLQEVAEAEGIEIDREALSFIAKRASGGLRDALTMLeQVWKFSEGKITLETVHEALG 240
|
|
| PRK08691 |
PRK08691 |
DNA polymerase III subunits gamma and tau; Validated |
1-317 |
6.34e-25 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236333 [Multi-domain] Cd Length: 709 Bit Score: 105.18 E-value: 6.34e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 1 MVEKYRPQTLNDLISHQDILSTIQKFINEDRLPH-LLLYGPPGTGKTSTILACAKQLYKDK----------------EFG 63
Cdd:PRK08691 6 LARKWRPKTFADLVGQEHVVKALQNALDEGRLHHaYLLTGTRGVGKTTIARILAKSLNCENaqhgepcgvcqsctqiDAG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 64 SMV--LELNASDDRGIDIIRgPILSFASTRTIFKKgFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKII 141
Cdd:PRK08691 86 RYVdlLEIDAASNTGIDNIR-EVLENAQYAPTAGK-YKVYIIDEVHMLSKSAFNAMLKTLEEPPEHVKFILATTDPHKVP 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 142 PALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL-QSTNMAFGKVTEETVYTCTGH 220
Cdd:PRK08691 164 VTVLSRCLQFVLRNMTAQQVADHLAHVLDSEKIAYEPPALQLLGRAAAGSMRDALSLLdQAIALGSGKVAENDVRQMIGA 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 221 PLKSDIANILDWMLNQDFTTAYRNITELKTlKGLALHDILTEIHLFVHRVDFPSSVRIHLLTK--MADIEYRLSVG-TNE 297
Cdd:PRK08691 244 VDKQYLYELLTGIINQDGAALLAKAQEMAA-CAVGFDNALGELAILLQQLALIQAVPSALAHDdpDSDILHRLAQTiSGE 322
|
330 340
....*....|....*....|
gi 194306567 298 KIQLSSLIAAfQVTRDLIVA 317
Cdd:PRK08691 323 QIQLYYQIAV-HGKRDLSLA 341
|
|
| PRK05563 |
PRK05563 |
DNA polymerase III subunits gamma and tau; Validated |
4-248 |
1.33e-22 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 235505 [Multi-domain] Cd Length: 559 Bit Score: 98.02 E-value: 1.33e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 4 KYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLY-GPPGTGKTST--ILA----CAKQlyKDKEF------------GS 64
Cdd:PRK05563 9 KWRPQTFEDVVGQEHITKTLKNAIKQGKISHAYLFsGPRGTGKTSAakIFAkavnCLNP--PDGEPcneceickaitnGS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 65 M--VLELNASDDRGIDIIRgPILS---FASTRTIFKkgfklV-ILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLS 138
Cdd:PRK05563 87 LmdVIEIDAASNNGVDEIR-DIRDkvkYAPSEAKYK-----VyIIDEVHMLSTGAFNALLKTLEEPPAHVIFILATTEPH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 139 KIIPALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL-QSTNMAFGKVTEETVYTC 217
Cdd:PRK05563 161 KIPATILSRCQRFDFKRISVEDIVERLKYILDKEGIEYEDEALRLIARAAEGGMRDALSILdQAISFGDGKVTYEDALEV 240
|
250 260 270
....*....|....*....|....*....|.
gi 194306567 218 TGHPLKSDIANILDWMLNQDFTTAYRNITEL 248
Cdd:PRK05563 241 TGSVSQEALDDLVDAIVEGDVAKALKILEEL 271
|
|
| PRK05896 |
PRK05896 |
DNA polymerase III subunits gamma and tau; Validated |
3-263 |
1.52e-22 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 235638 [Multi-domain] Cd Length: 605 Bit Score: 97.99 E-value: 1.52e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 3 EKYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLY-GPPGTGKTSTILACAKQL----YKD--------------KEFG 63
Cdd:PRK05896 8 RKYRPHNFKQIIGQELIKKILVNAILNNKLTHAYIFsGPRGIGKTSIAKIFAKAInclnPKDgdccnscsvcesinTNQS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 64 SMVLELNASDDRGIDIIRGPILSFASTRTIFKKgfKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPA 143
Cdd:PRK05896 88 VDIVELDAASNNGVDEIRNIIDNINYLPTTFKY--KVYIIDEAHMLSTSAWNALLKTLEEPPKHVVFIFATTEFQKIPLT 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 144 LQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL-QSTNMAFGKVTEETVYTCTGHPL 222
Cdd:PRK05896 166 IISRCQRYNFKKLNNSELQELLKSIAKKEKIKIEDNAIDKIADLADGSLRDGLSILdQLSTFKNSEIDIEDINKTFGLVD 245
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 194306567 223 KSDIANILDWMLNQDFTTAYRNITELKTlKGLALHDILTEI 263
Cdd:PRK05896 246 NNKKINLIELIQKNDIEELRNLINELES-KGINFEAFCRDL 285
|
|
| RarA |
COG2256 |
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, ... |
6-199 |
2.51e-22 |
|
Replication-associated recombination protein RarA (DNA-dependent ATPase) [Replication, recombination and repair];
Pssm-ID: 441857 [Multi-domain] Cd Length: 439 Bit Score: 96.66 E-value: 2.51e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 6 RPQTLNDLISHQDIL---STIQKFINEDRLPHLLLYGPPGTGKTStiLA--CAKQLykDKEFgsmvLELNASDDrGIDII 80
Cdd:COG2256 20 RPRTLDEVVGQEHLLgpgKPLRRAIEAGRLSSMILWGPPGTGKTT--LArlIANAT--DAEF----VALSAVTS-GVKDI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 81 RGpILSFASTRTIFKKGFkLVILDEADAMTQDAQNALRRVIEK----F----TENTRFclicnylsKIIPALQSRCTRFR 152
Cdd:COG2256 91 RE-VIEEARERRAYGRRT-ILFVDEIHRFNKAQQDALLPHVEDgtitLigatTENPSF--------EVNSALLSRCRVFV 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 194306567 153 FGPLTPELMVPRLEHVVEEE-------KVDISEDGMKALVTLSSGDMRRALNIL 199
Cdd:COG2256 161 LKPLSEEDLEQLLERALADDerglggyKLELDDEALEALARLADGDARRALNAL 214
|
|
| AAA |
cd00009 |
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ... |
14-155 |
6.35e-22 |
|
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.
Pssm-ID: 99707 [Multi-domain] Cd Length: 151 Bit Score: 89.90 E-value: 6.35e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 14 ISHQDILSTIQKFINEDRLPHLLLYGPPGTGKTSTILACAKQLykdKEFGSMVLELNASDDRGIDIIRGPILSFASTRTI 93
Cdd:cd00009 1 VGQEEAIEALREALELPPPKNLLLYGPPGTGKTTLARAIANEL---FRPGAPFLYLNASDLLEGLVVAELFGHFLVRLLF 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 194306567 94 FKK---GFKLVILDEADAMTQDAQNALRRVIEKF------TENTRFCLICNY--LSKIIPALQSRC-TRFRFGP 155
Cdd:cd00009 78 ELAekaKPGVLFIDEIDSLSRGAQNALLRVLETLndlridRENVRVIGATNRplLGDLDRALYDRLdIRIVIPL 151
|
|
| PRK14965 |
PRK14965 |
DNA polymerase III subunits gamma and tau; Provisional |
4-219 |
1.57e-21 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237871 [Multi-domain] Cd Length: 576 Bit Score: 94.81 E-value: 1.57e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 4 KYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLY-GPPGTGKTSTILACAKQLykDKEFGSM----------------- 65
Cdd:PRK14965 9 KYRPQTFSDLTGQEHVSRTLQNAIDTGRVAHAFLFtGARGVGKTSTARILAKAL--NCEQGLTaepcnvcppcveitegr 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 66 ---VLELNASDDRGIDIIRGpiLSFASTRTIFKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIP 142
Cdd:PRK14965 87 svdVFEIDGASNTGVDDIRE--LRENVKYLPSRSRYKIFIIDEVHMLSTNAFNALLKTLEEPPPHVKFIFATTEPHKVPI 164
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194306567 143 ALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTNMAFGK-VTEETVYTCTG 219
Cdd:PRK14965 165 TILSRCQRFDFRRIPLQKIVDRLRYIADQEGISISDAALALVARKGDGSMRDSLSTLDQVLAFCGDaVGDDDVAELLG 242
|
|
| holB |
TIGR00678 |
DNA polymerase III, delta' subunit; This model describes the N-terminal half of the delta' ... |
23-167 |
5.42e-21 |
|
DNA polymerase III, delta' subunit; This model describes the N-terminal half of the delta' subunit of DNA polymerase III. Delta' is homologous to the gamma and tau subunits, which form an outgroup for phylogenetic comparison. The gamma/tau branch of the tree is much more tighly conserved than the delta' branch, and some members of that branch score more highly against this model than some proteins classisified as delta'. The noise cutoff is set to detect weakly scoring delta' subunits rather than to exclude gamma/tau subunits. At position 126-127 of the seed alignment, this family lacks the HM motif of gamma/tau; at 132 it has a near-invariant A vs. an invariant F in gamma/tau. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273213 [Multi-domain] Cd Length: 188 Bit Score: 88.45 E-value: 5.42e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 23 IQKFINEDRLPH-LLLYGPPGTGKTSTILACAKQLYKDKEFGS--------------------MVLELNAsDDRGIDIIR 81
Cdd:TIGR00678 4 LKRALEKGRLAHaYLFTGPEGVGKELLALALAKALLCEQRGGGepcgechscrlieagnhpdlHRLEPEG-QSIKVDQVR 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 82 GpILSFASTRTIfKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPLTPELM 161
Cdd:TIGR00678 83 E-LVEFLSRTPQ-ESGRRVVIIEDAERMNEAAANALLKTLEEPPPNTLFILITPSPEKLLPTIRSRCQRLPFPPLSEEAL 160
|
....*.
gi 194306567 162 VPRLEH 167
Cdd:TIGR00678 161 LQWLIR 166
|
|
| PRK14961 |
PRK14961 |
DNA polymerase III subunits gamma and tau; Provisional |
1-270 |
6.11e-21 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 184925 [Multi-domain] Cd Length: 363 Bit Score: 91.80 E-value: 6.11e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 1 MVEKYRPQTLNDLISHQDILSTIQKFINEDRLPHL-LLYGPPGTGKTSTILACAKQLY----------------KDKEFG 63
Cdd:PRK14961 6 LARKWRPQYFRDIIGQKHIVTAISNGLSLGRIHHAwLLSGTRGVGKTTIARLLAKSLNcqngitsnpcrkciicKEIEKG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 64 SM--VLELNASDDRGIDIIRGPILSFASTRTifKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKII 141
Cdd:PRK14961 86 LCldLIEIDAASRTKVEEMREILDNIYYSPS--KSRFKVYLIDEVHMLSRHSFNALLKTLEEPPQHIKFILATTDVEKIP 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 142 PALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL-QSTNMAFGKVTEETVYTCTGH 220
Cdd:PRK14961 164 KTILSRCLQFKLKIISEEKIFNFLKYILIKESIDTDEYALKLIAYHAHGSMRDALNLLeHAINLGKGNINIKNVTDMLGL 243
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 194306567 221 PLKSDIANILDWMLNQDFTTAYRNITELKTLkGLALHDILTEIHLFVHRV 270
Cdd:PRK14961 244 LNEKQSFLLTDALLKKDSKKTMLLLNKISSI-GIEWENILIEMLRFLHHI 292
|
|
| HLD_clamp_RFC |
cd18140 |
helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein ... |
156-218 |
2.03e-20 |
|
helical lid domain of replication factor C subunit; Replication factor C (RFC) is five-protein clamp loader complex that forms a stable ATP-dependent complex with the sliding clamp, PCNA, which binds specifically to primed DNA. RFC subunits belong to the clamp loader clade of the AAA+ superfamily.
Pssm-ID: 350842 [Multi-domain] Cd Length: 63 Bit Score: 82.96 E-value: 2.03e-20
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194306567 156 LTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTNMAFGKVTEETVYTCT 218
Cdd:cd18140 1 LSKEQIVKRLREICKKEGVKIDEEALEAIAEKSEGDMRKAINDLQAAAAGGGVITEEDVYEVA 63
|
|
| PRK14964 |
PRK14964 |
DNA polymerase III subunits gamma and tau; Provisional |
4-241 |
5.74e-20 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237870 [Multi-domain] Cd Length: 491 Bit Score: 89.84 E-value: 5.74e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 4 KYRPQTLNDLIShQDILSTI-QKFINEDRLPH-LLLYGPPGTGKTST------ILACAKQLYKD-----------KEFGS 64
Cdd:PRK14964 6 KYRPSSFKDLVG-QDVLVRIlRNAFTLNKIPQsILLVGASGVGKTTCariislCLNCSNGPTSDpcgtchncisiKNSNH 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 65 M-VLELNASDDRGIDIIRgPILSFASTRTIFKKgFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPA 143
Cdd:PRK14964 85 PdVIEIDAASNTSVDDIK-VILENSCYLPISSK-FKVYIIDEVHMLSNSAFNALLKTLEEPAPHVKFILATTEVKKIPVT 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 144 LQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL-QSTNMAFGKVTEETVYTCTGHPL 222
Cdd:PRK14964 163 IISRCQRFDLQKIPTDKLVEHLVDIAKKENIEHDEESLKLIAENSSGSMRNALFLLeQAAIYSNNKISEKSVRDLLGCVD 242
|
250
....*....|....*....
gi 194306567 223 KSDIANILDWMLNQDFTTA 241
Cdd:PRK14964 243 KHILEDLVEAILLGDAQSA 261
|
|
| PRK14970 |
PRK14970 |
DNA polymerase III subunits gamma and tau; Provisional |
4-230 |
6.91e-20 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 184934 [Multi-domain] Cd Length: 367 Bit Score: 88.78 E-value: 6.91e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 4 KYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLY-GPPGTGKTSTILACAKQL----YKDKE--FGSMVLELNASDDRG 76
Cdd:PRK14970 10 KYRPQTFDDVVGQSHITNTLLNAIENNHLAQALLFcGPRGVGKTTCARILARKInqpgYDDPNedFSFNIFELDAASNNS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 77 IDIIRGPIlsfASTRTIFKKG-FKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGP 155
Cdd:PRK14970 90 VDDIRNLI---DQVRIPPQTGkYKIYIIDEVHMLSSAAFNAFLKTLEEPPAHAIFILATTEKHKIIPTILSRCQIFDFKR 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 156 LTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQ------STNMAFGKVTE-------ETVYTCTGHPL 222
Cdd:PRK14970 167 ITIKDIKEHLAGIAVKEGIKFEDDALHIIAQKADGALRDALSIFDrvvtfcGKNITRQAVTEnlnildyDTYINVTDLIL 246
|
....*...
gi 194306567 223 KSDIANIL 230
Cdd:PRK14970 247 ENKIPELL 254
|
|
| PRK14963 |
PRK14963 |
DNA polymerase III subunits gamma and tau; Provisional |
3-221 |
6.02e-19 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 184927 [Multi-domain] Cd Length: 504 Bit Score: 87.20 E-value: 6.02e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 3 EKYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLY-GPPGTGKTST--ILA----CAKQLykDKEFGSM---------- 65
Cdd:PRK14963 6 QRARPITFDEVVGQEHVKEVLLAALRQGRLGHAYLFsGPRGVGKTTTarLIAmavnCSGED--PKPCGECesclavrrga 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 66 ---VLELNASDDRGIDIIRG--PILSFASTRTifkkGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKI 140
Cdd:PRK14963 84 hpdVLEIDAASNNSVEDVRDlrEKVLLAPLRG----GRKVYILDEAHMMSKSAFNALLKTLEEPPEHVIFILATTEPEKM 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 141 IPALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTNMAFGKVTEETVYTCTGH 220
Cdd:PRK14963 160 PPTILSRTQHFRFRRLTEEEIAGKLRRLLEAEGREAEPEALQLVARLADGAMRDAESLLERLLALGTPVTRKQVEEALGL 239
|
.
gi 194306567 221 P 221
Cdd:PRK14963 240 P 240
|
|
| AAA |
pfam00004 |
ATPase family associated with various cellular activities (AAA); AAA family proteins often ... |
35-156 |
1.28e-18 |
|
ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.
Pssm-ID: 459627 [Multi-domain] Cd Length: 130 Bit Score: 80.33 E-value: 1.28e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 35 LLLYGPPGTGKTSTILACAkqlykdKEFGSMVLELNASDDRGIDIIRGPilsfASTRTIFKKGFKL----VILDEADAM- 109
Cdd:pfam00004 1 LLLYGPPGTGKTTLAKAVA------KELGAPFIEISGSELVSKYVGESE----KRLRELFEAAKKLapcvIFIDEIDALa 70
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 110 ----------TQDAQNALRRVIEKFT---ENTRFCLICNYLSKIIPALQSRCTRFRFGPL 156
Cdd:pfam00004 71 gsrgsggdseSRRVVNQLLTELDGFTssnSKVIVIAATNRPDKLDPALLGRFDRIIEFPL 130
|
|
| PRK13341 |
PRK13341 |
AAA family ATPase; |
3-200 |
4.53e-18 |
|
AAA family ATPase;
Pssm-ID: 237354 [Multi-domain] Cd Length: 725 Bit Score: 84.72 E-value: 4.53e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 3 EKYRPQTLNDLISHQDILST---IQKFINEDRLPHLLLYGPPGTGKTStiLACAKQLYKDKEFGSM------VLELNASD 73
Cdd:PRK13341 20 DRLRPRTLEEFVGQDHILGEgrlLRRAIKADRVGSLILYGPPGVGKTT--LARIIANHTRAHFSSLnavlagVKDLRAEV 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 74 DRGIDiirgpILSFASTRTIfkkgfklVILDEADAMTQDAQNALRRVIEK--------FTENTRFclicnylsKIIPALQ 145
Cdd:PRK13341 98 DRAKE-----RLERHGKRTI-------LFIDEVHRFNKAQQDALLPWVENgtitligaTTENPYF--------EVNKALV 157
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 194306567 146 SRCTRFRFGPLTPELMVPRLEHVVEEE-------KVDISEDGMKALVTLSSGDMRRALNILQ 200
Cdd:PRK13341 158 SRSRLFRLKSLSDEDLHQLLKRALQDKergygdrKVDLEPEAEKHLVDVANGDARSLLNALE 219
|
|
| PRK06305 |
PRK06305 |
DNA polymerase III subunits gamma and tau; Validated |
4-216 |
2.45e-16 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 180523 [Multi-domain] Cd Length: 451 Bit Score: 79.05 E-value: 2.45e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 4 KYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLY-GPPGTGKTSTILACAKQLY-----------------KDKEFGSM 65
Cdd:PRK06305 10 KYRPQTFSEILGQDAVVAVLKNALRFNRAAHAYLFsGIRGTGKTTLARIFAKALNcqnptedqepcnqcascKEISSGTS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 66 --VLELNASDDRGIDIIR--GPILSFASTrtifKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKII 141
Cdd:PRK06305 90 ldVLEIDGASHRGIEDIRqiNETVLFTPS----KSRYKIYIIDEVHMLTKEAFNSLLKTLEEPPQHVKFFLATTEIHKIP 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 142 PALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL-------------QSTNMAFGK 208
Cdd:PRK06305 166 GTILSRCQKMHLKRIPEETIIDKLALIAKQEGIETSREALLPIARAAQGSLRDAESLYdyvvglfpksldpDSVAKALGL 245
|
....*...
gi 194306567 209 VTEETVYT 216
Cdd:PRK06305 246 LSQDSLYT 253
|
|
| PRK14969 |
PRK14969 |
DNA polymerase III subunits gamma and tau; Provisional |
4-237 |
7.80e-16 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237873 [Multi-domain] Cd Length: 527 Bit Score: 77.87 E-value: 7.80e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 4 KYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLY-GPPGTGKT--STILA----------------CAKQLYKDKefGS 64
Cdd:PRK14969 9 KWRPKSFSELVGQEHVVRALTNALEQQRLHHAYLFtGTRGVGKTtlARILAkslncetgvtatpcgvCSACLEIDS--GR 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 65 MV--LELNASDDRGIDIIRgPILS---FASTRTifkkGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSK 139
Cdd:PRK14969 87 FVdlIEVDAASNTQVDAMR-ELLDnaqYAPTRG----RFKVYIIDEVHMLSKSAFNAMLKTLEEPPEHVKFILATTDPQK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 140 IIPALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTnMAFG--KVTEETVYTC 217
Cdd:PRK14969 162 IPVTVLSRCLQFNLKQMPPPLIVSHLQHILEQENIPFDATALQLLARAAAGSMRDALSLLDQA-IAYGggTVNESEVRAM 240
|
250 260
....*....|....*....|
gi 194306567 218 TGHPLKSDIANILDWMLNQD 237
Cdd:PRK14969 241 LGAIDQDYLFALLEALLAQD 260
|
|
| PRK07471 |
PRK07471 |
DNA polymerase III subunit delta'; Validated |
30-199 |
1.76e-15 |
|
DNA polymerase III subunit delta'; Validated
Pssm-ID: 236022 [Multi-domain] Cd Length: 365 Bit Score: 76.22 E-value: 1.76e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 30 DRLPH-LLLYGPPGTGKTST-------ILA-----------------------CAKQLYKDKEFGSMVLELNASDDRG-- 76
Cdd:PRK07471 38 GRLHHaWLIGGPQGIGKATLayrmarfLLAtpppggdgavppptslaidpdhpVARRIAAGAHGGLLTLERSWNEKGKrl 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 77 -----IDIIRGPILSFASTRTIfkKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRF 151
Cdd:PRK07471 118 rtvitVDEVRELISFFGLTAAE--GGWRVVIVDTADEMNANAANALLKVLEEPPARSLFLLVSHAPARLLPTIRSRCRKL 195
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 194306567 152 RFGPLTPELMVPRLehvvEEEKVDISEDGMKALVTLSSGDMRRALNIL 199
Cdd:PRK07471 196 RLRPLAPEDVIDAL----AAAGPDLPDDPRAALAALAEGSVGRALRLA 239
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
4-214 |
3.50e-15 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 76.07 E-value: 3.50e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 4 KYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLY-GPPGTGKT--STILACAKQLYKDKEFGSMV-------------- 66
Cdd:PRK12323 9 KWRPRDFTTLVGQEHVVRALTHALEQQRLHHAYLFtGTRGVGKTtlSRILAKSLNCTGADGEGGITaqpcgqcracteid 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 67 -------LELNASDDRGIDIIrGPILSfastRTIFKKG---FKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNY 136
Cdd:PRK12323 89 agrfvdyIEMDAASNRGVDEM-AQLLD----KAVYAPTagrFKVYMIDEVHMLTNHAFNAMLKTLEEPPEHVKFILATTD 163
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194306567 137 LSKIIPALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL-QSTNMAFGKVTEETV 214
Cdd:PRK12323 164 PQKIPVTVLSRCLQFNLKQMPPGHIVSHLDAILGEEGIAHEVNALRLLAQAAQGSMRDALSLTdQAIAYSAGNVSEEAV 242
|
|
| PRK14952 |
PRK14952 |
DNA polymerase III subunits gamma/tau; |
4-199 |
4.73e-15 |
|
DNA polymerase III subunits gamma/tau;
Pssm-ID: 237866 [Multi-domain] Cd Length: 584 Bit Score: 75.69 E-value: 4.73e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 4 KYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLY-GPPGTGKTST--ILA----CAK--------------QLYKDKEf 62
Cdd:PRK14952 6 KYRPATFAEVVGQEHVTEPLSSALDAGRINHAYLFsGPRGCGKTSSarILArslnCAQgptatpcgvcescvALAPNGP- 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 63 GSM-VLELNASDDRGIDIIRG----PILSFASTRtifkkgFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYL 137
Cdd:PRK14952 85 GSIdVVELDAASHGGVDDTRElrdrAFYAPAQSR------YRIFIVDEAHMVTTAGFNALLKIVEEPPEHLIFIFATTEP 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194306567 138 SKIIPALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDIsEDGMKALVTLS-SGDMRRALNIL 199
Cdd:PRK14952 159 EKVLPTIRSRTHHYPFRLLPPRTMRALIARICEQEGVVV-DDAVYPLVIRAgGGSPRDTLSVL 220
|
|
| PRK08451 |
PRK08451 |
DNA polymerase III subunits gamma and tau; Validated |
4-248 |
5.54e-15 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236267 [Multi-domain] Cd Length: 535 Bit Score: 75.46 E-value: 5.54e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 4 KYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLY-GPPGTGKTSTILACAKQLYKDKEFGSM----------------- 65
Cdd:PRK08451 7 KYRPKHFDELIGQESVSKTLSLALDNNRLAHAYLFsGLRGSGKTSSARIFARALVCEQGPSSTpcdtciqcqsalenrhi 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 66 -VLELNASDDRGIDIIRGPI------LSFAStrtifkkgFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLS 138
Cdd:PRK08451 87 dIIEMDAASNRGIDDIRELIeqtkykPSMAR--------FKIFIIDEVHMLTKEAFNALLKTLEEPPSYVKFILATTDPL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 139 KIIPALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL-QSTNMAFGKVTEETVYTC 217
Cdd:PRK08451 159 KLPATILSRTQHFRFKQIPQNSIISHLKTILEKEGVSYEPEALEILARSGNGSLRDTLTLLdQAIIYCKNAITESKVADM 238
|
250 260 270
....*....|....*....|....*....|.
gi 194306567 218 TGHPLKSDIANILDWMLNQDFTTAYRNITEL 248
Cdd:PRK08451 239 LGLLDPSKLEDFFQAILNQDKEKLFELLKEL 269
|
|
| PRK09112 |
PRK09112 |
DNA polymerase III subunit delta'; Validated |
7-200 |
8.20e-15 |
|
DNA polymerase III subunit delta'; Validated
Pssm-ID: 169667 [Multi-domain] Cd Length: 351 Bit Score: 73.92 E-value: 8.20e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 7 PQTLNDLISHQDILSTIQKFINEDRLPHLLLY-GPPGTGKTS-------TIL-----ACAKQLYKDKEFGSMVLELNAS- 72
Cdd:PRK09112 19 PSENTRLFGHEEAEAFLAQAYREGKLHHALLFeGPEGIGKATlafhlanHILshpdpAEAPETLADPDPASPVWRQIAQg 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 73 ------------DDRG--------IDIIRGpILSFAStRTIFKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCL 132
Cdd:PRK09112 99 ahpnllhitrpfDEKTgkfktaitVDEIRR-VGHFLS-QTSGDGNWRIVIIDPADDMNRNAANAILKTLEEPPARALFIL 176
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194306567 133 ICNYLSKIIPALQSRCTRFRFGPLTPELMVPRLEHVveEEKVDISEDGMKALVTLSSGDMRRALNILQ 200
Cdd:PRK09112 177 ISHSSGRLLPTIRSRCQPISLKPLDDDELKKALSHL--GSSQGSDGEITEALLQRSKGSVRKALLLLN 242
|
|
| PRK05564 |
PRK05564 |
DNA polymerase III subunit delta'; Validated |
12-190 |
9.59e-15 |
|
DNA polymerase III subunit delta'; Validated
Pssm-ID: 180132 [Multi-domain] Cd Length: 313 Bit Score: 73.53 E-value: 9.59e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 12 DLISHQDILSTIQKFINEDRLPHL-LLYGPPGTGKTstILAcakqlykdKEFGSMVLELNaSDDRGIDIIRGPILSFAS- 89
Cdd:PRK05564 5 TIIGHENIKNRIKNSIIKNRFSHAhIIVGEDGIGKS--LLA--------KEIALKILGKS-QQREYVDIIEFKPINKKSi 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 90 ----TRTIF----KKGF----KLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPLT 157
Cdd:PRK05564 74 gvddIRNIIeevnKKPYegdkKVIIIYNSEKMTEQAQNAFLKTIEEPPKGVFIILLCENLEQILDTIKSRCQIYKLNRLS 153
|
170 180 190
....*....|....*....|....*....|...
gi 194306567 158 PELMvprlEHVVEEEKVDISEDGMKALVTLSSG 190
Cdd:PRK05564 154 KEEI----EKFISYKYNDIKEEEKKSAIAFSDG 182
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
4-270 |
1.37e-14 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 74.37 E-value: 1.37e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 4 KYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLY-GPPGTGKT--STILA---------------------CakQLYKD 59
Cdd:PRK14951 9 KYRPRSFSEMVGQEHVVQALTNALTQQRLHHAYLFtGTRGVGKTtvSRILAkslncqgpdgqggitatpcgvC--QACRD 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 60 KEFGSMV--LELNASDDRGIDIIRGpILSFAstrtIFK--KG-FKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLIC 134
Cdd:PRK14951 87 IDSGRFVdyTELDAASNRGVDEVQQ-LLEQA----VYKpvQGrFKVFMIDEVHMLTNTAFNAMLKTLEEPPEYLKFVLAT 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 135 NYLSKIIPALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL-QSTNMAFGKVTEET 213
Cdd:PRK14951 162 TDPQKVPVTVLSRCLQFNLRPMAPETVLEHLTQVLAAENVPAEPQALRLLARAARGSMRDALSLTdQAIAFGSGQLQEAA 241
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 194306567 214 VYTCTGHPLKSDIANILDWMLNQDFTTAYRNITELKTlKGLALHDILTEIHLFVHRV 270
Cdd:PRK14951 242 VRQMLGSVDRSHVFRLIDALAQGDGRTVVETADELRL-NGLSAASTLEEMAAVLQRM 297
|
|
| PRK14971 |
PRK14971 |
DNA polymerase III subunit gamma/tau; |
4-232 |
1.63e-13 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237874 [Multi-domain] Cd Length: 614 Bit Score: 70.96 E-value: 1.63e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 4 KYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLY-GPPGTGKTStilaCAKQLYK---------DKE----------FG 63
Cdd:PRK14971 10 KYRPSTFESVVGQEALTTTLKNAIATNKLAHAYLFcGPRGVGKTT----CARIFAKtincqnltaDGEacnecescvaFN 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 64 ---SM-VLELNASDDRGIDIIRGPILSFASTRTIFKkgFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSK 139
Cdd:PRK14971 86 eqrSYnIHELDAASNNSVDDIRNLIEQVRIPPQIGK--YKIYIIDEVHMLSQAAFNAFLKTLEEPPSYAIFILATTEKHK 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 140 IIPALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL-QSTNMAFGKVTEETVYtct 218
Cdd:PRK14971 164 ILPTILSRCQIFDFNRIQVADIVNHLQYVASKEGITAEPEALNVIAQKADGGMRDALSIFdQVVSFTGGNITYKSVI--- 240
|
250
....*....|....
gi 194306567 219 ghplksDIANILDW 232
Cdd:PRK14971 241 ------ENLNILDY 248
|
|
| PRK06647 |
PRK06647 |
DNA polymerase III subunits gamma and tau; Validated |
4-195 |
6.92e-13 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 235845 [Multi-domain] Cd Length: 563 Bit Score: 69.03 E-value: 6.92e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 4 KYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLY-GPPGTGKTSTILACAKQLY----------------KDKEFGSM- 65
Cdd:PRK06647 9 KRRPRDFNSLEGQDFVVETLKHSIESNKIANAYIFsGPRGVGKTSSARAFARCLNcvngptpmpcgecsscKSIDNDNSl 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 66 -VLELNASDDRGI-DI--IRGPILsF--ASTRtifkkgFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSK 139
Cdd:PRK06647 89 dVIEIDGASNTSVqDVrqIKEEIM-FppASSR------YRVYIIDEVHMLSNSAFNALLKTIEEPPPYIVFIFATTEVHK 161
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 194306567 140 IIPALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRA 195
Cdd:PRK06647 162 LPATIKSRCQHFNFRLLSLEKIYNMLKKVCLEDQIKYEDEALKWIAYKSTGSVRDA 217
|
|
| PRK14959 |
PRK14959 |
DNA polymerase III subunits gamma and tau; Provisional |
1-199 |
7.49e-13 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 184923 [Multi-domain] Cd Length: 624 Bit Score: 68.94 E-value: 7.49e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 1 MVEKYRPQTLNDLISHQDILSTIQKFINEDRL-PHLLLYGPPGTGKTST--ILA----CAK-----------QLYKDKEF 62
Cdd:PRK14959 6 LTARYRPQTFAEVAGQETVKAILSRAAQENRVaPAYLFSGTRGVGKTTIarIFAkalnCETaptgepcntceQCRKVTQG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 63 GSM-VLELNASDDRGIDIIRGpiLSFASTRTIFKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKII 141
Cdd:PRK14959 86 MHVdVVEIDGASNRGIDDAKR--LKEAIGYAPMEGRYKVFIIDEAHMLTREAFNALLKTLEEPPARVTFVLATTEPHKFP 163
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 194306567 142 PALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL 199
Cdd:PRK14959 164 VTIVSRCQHFTFTRLSEAGLEAHLTKVLGREGVDYDPAAVRLIARRAAGSVRDSMSLL 221
|
|
| rad24 |
TIGR00602 |
checkpoint protein rad24; All proteins in this family for which functions are known are ... |
2-200 |
1.04e-12 |
|
checkpoint protein rad24; All proteins in this family for which functions are known are involved in DNA damage tolerance (likely cell cycle checkpoints).This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129690 [Multi-domain] Cd Length: 637 Bit Score: 68.44 E-value: 1.04e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 2 VEKYRPQTLNDLISHQDILSTIQKFINEDRLPH-----LLLYGPPGTGKTSTILACAKQL-YKDKEFGSMVLELNASDDR 75
Cdd:TIGR00602 75 VEKYKPETQHELAVHKKKIEEVETWLKAQVLENapkriLLITGPSGCGKSTTIKILSKELgIQVQEWSNPTLPDFQKNDH 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 76 GIDIIRG-------------PILSFASTRTIFKKG------FKLVILDEADAMTQDAQNALRRVIE-KFTENTRFCLIC- 134
Cdd:TIGR00602 155 KVTLSLEscfsnfqsqievfSEFLLRATNKLQMLGddlmtdKKIILVEDLPNQFYRDTRALHEILRwKYVSIGRCPLVFi 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 135 ---------NYLSKIIPALQS---------RCTRFRFGPLTPELMVPRLEHVVEEEKVDISED---GMKALVTL----SS 189
Cdd:TIGR00602 235 iteslegdnNQRRLLFPAETImnkeileepRVSNISFNPIAPTIMKKFLNRIVTIEAKKNGEKikvPKKTSVELlcqgCS 314
|
250
....*....|.
gi 194306567 190 GDMRRALNILQ 200
Cdd:TIGR00602 315 GDIRSAINSLQ 325
|
|
| PRK05707 |
PRK05707 |
DNA polymerase III subunit delta'; Validated |
24-273 |
1.05e-12 |
|
DNA polymerase III subunit delta'; Validated
Pssm-ID: 180215 [Multi-domain] Cd Length: 328 Bit Score: 67.81 E-value: 1.05e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 24 QKFINEDRLPH-LLLYGPPGTGKTS-------TIL--------ACAK----QLYKDkefGS----MVLE-LNASDDRGID 78
Cdd:PRK05707 13 QQLAGRGRHPHaYLLHGPAGIGKRAlaerlaaALLceapqgggACGSckgcQLLRA---GShpdnFVLEpEEADKTIKVD 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 79 IIRgPILSFAsTRTIFKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPLTP 158
Cdd:PRK05707 90 QVR-ELVSFV-VQTAQLGGRKVVLIEPAEAMNRNAANALLKSLEEPSGDTVLLLISHQPSRLLPTIKSRCQQQACPLPSN 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 159 ELMVPRLEHVVEEEkvdiSEDGMKALVTLSSGDMRRALNiLQSTNMAF---------GKVTE------ETVYTCTGHPLK 223
Cdd:PRK05707 168 EESLQWLQQALPES----DERERIELLTLAGGSPLRALQ-LHEQGVREqrarvldgvKKLLKqqqsasQLAESWLKVPLL 242
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 194306567 224 SDIANILDW---MLNQDFTTAYRnitelktlkGLALHDILTEIHLFVHRVDFP 273
Cdd:PRK05707 243 LLFDWFCDWahdILRYQLTQDEE---------GLGLADMRKVLQYLAQKSPQA 286
|
|
| PRK14960 |
PRK14960 |
DNA polymerase III subunit gamma/tau; |
1-208 |
1.23e-12 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237868 [Multi-domain] Cd Length: 702 Bit Score: 68.54 E-value: 1.23e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 1 MVEKYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLY-GPPGTGKTSTILACAKQLYKDKEFGSMVLELNAS-----DD 74
Cdd:PRK14960 5 LARKYRPRNFNELVGQNHVSRALSSALERGRLHHAYLFtGTRGVGKTTIARILAKCLNCETGVTSTPCEVCATckavnEG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 75 RGIDIIRGPILS---FASTRTIF--------KKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPA 143
Cdd:PRK14960 85 RFIDLIEIDAASrtkVEDTRELLdnvpyaptQGRFKVYLIDEVHMLSTHSFNALLKTLEEPPEHVKFLFATTDPQKLPIT 164
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194306567 144 LQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNiLQSTNMAFGK 208
Cdd:PRK14960 165 VISRCLQFTLRPLAVDEITKHLGAILEKEQIAADQDAIWQIAESAQGSLRDALS-LTDQAIAYGQ 228
|
|
| PRK14956 |
PRK14956 |
DNA polymerase III subunits gamma and tau; Provisional |
4-200 |
1.40e-12 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 184920 [Multi-domain] Cd Length: 484 Bit Score: 68.05 E-value: 1.40e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 4 KYRPQTLNDLIsHQDI-LSTIQKFINEDRLPH-LLLYGPPGTGKTST--ILA----------------CAKQLYKDKEFG 63
Cdd:PRK14956 11 KYRPQFFRDVI-HQDLaIGALQNALKSGKIGHaYIFFGPRGVGKTTIarILAkrlncenpignepcneCTSCLEITKGIS 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 64 SMVLELNASDDRGIDIIRG--PILSFAStrtiFKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKII 141
Cdd:PRK14956 90 SDVLEIDAASNRGIENIRElrDNVKFAP----MGGKYKVYIIDEVHMLTDQSFNALLKTLEEPPAHIVFILATTEFHKIP 165
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 194306567 142 PALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQ 200
Cdd:PRK14956 166 ETILSRCQDFIFKKVPLSVLQDYSEKLCKIENVQYDQEGLFWIAKKGDGSVRDMLSFME 224
|
|
| DNA_pol3_delta2 |
pfam13177 |
DNA polymerase III, delta subunit; DNA polymerase III, delta subunit (EC 2.7.7.7) is required ... |
22-157 |
1.61e-12 |
|
DNA polymerase III, delta subunit; DNA polymerase III, delta subunit (EC 2.7.7.7) is required for, along with delta' subunit, the assembly of the processivity factor beta(2) onto primed DNA in the DNA polymerase III holoenzyme-catalyzed reaction. The delta subunit is also known as HolA.
Pssm-ID: 433013 [Multi-domain] Cd Length: 161 Bit Score: 64.54 E-value: 1.61e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 22 TIQKFINE---DRLPH-LLLYGPPGTGKTSTILACAKQLYKDKEFGSM----------VLELNASDDR---------GID 78
Cdd:pfam13177 5 AIQLLQNSlenGRLSHaYLFSGPEGVGKLELALAFAKALFCEEPGDDLpcgqcrscrrIESGNHPDLViiepegqsiKID 84
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194306567 79 IIRGpILSFASTRTIFKKgFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPLT 157
Cdd:pfam13177 85 QIRE-LQKEFSKSPYEGK-KKVYIIEDAEKMTASAANSLLKFLEEPPGNTVIILLTENPSRLLPTIRSRCQIIRFKPLS 161
|
|
| PRK14955 |
PRK14955 |
DNA polymerase III subunits gamma and tau; Provisional |
4-199 |
6.07e-12 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 184919 [Multi-domain] Cd Length: 397 Bit Score: 65.68 E-value: 6.07e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 4 KYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLY-GPPGTGKTSTILACAK-----QLYKDKEFGSMVLE--------- 68
Cdd:PRK14955 9 KYRPKKFADITAQEHITRTIQNSLRMGRVGHGYIFsGLRGVGKTTAARVFAKavncqRMIDDADYLQEVTEpcgecescr 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 69 ------------LNASDDRGIDIIRgpiLSFASTRTIFKKG-FKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICN 135
Cdd:PRK14955 89 dfdagtslniseFDAASNNSVDDIR---LLRENVRYGPQKGrYRVYIIDEVHMLSIAAFNAFLKTLEEPPPHAIFIFATT 165
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 194306567 136 YLSKIIPALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL 199
Cdd:PRK14955 166 ELHKIPATIASRCQRFNFKRIPLEEIQQQLQGICEAEGISVDADALQLIGRKAQGSMRDAQSIL 229
|
|
| PRK14954 |
PRK14954 |
DNA polymerase III subunits gamma and tau; Provisional |
4-211 |
6.43e-12 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 184918 [Multi-domain] Cd Length: 620 Bit Score: 66.12 E-value: 6.43e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 4 KYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLY-GPPGTGKTSTILACAKQLY------------------------K 58
Cdd:PRK14954 9 KYRPSKFADITAQEHITHTIQNSLRMDRVGHGYIFsGLRGVGKTTAARVFAKAVNcqrmiddpvylqevtepcgecescR 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 59 DKEFG-SM-VLELNASDDRGIDIIRgpiLSFASTRTIFKKG-FKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICN 135
Cdd:PRK14954 89 DFDAGtSLnISEFDAASNNSVDDIR---QLRENVRYGPQKGrYRVYIIDEVHMLSTAAFNAFLKTLEEPPPHAIFIFATT 165
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194306567 136 YLSKIIPALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTnMAFGKVTE 211
Cdd:PRK14954 166 ELHKIPATIASRCQRFNFKRIPLDEIQSQLQMICRAEGIQIDADALQLIARKAQGSMRDAQSILDQV-IAFSVGSE 240
|
|
| PRK14958 |
PRK14958 |
DNA polymerase III subunits gamma and tau; Provisional |
1-231 |
8.65e-12 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 184922 [Multi-domain] Cd Length: 509 Bit Score: 65.52 E-value: 8.65e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 1 MVEKYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLY-GPPGTGKTSTILACAKQLYKDKEFGSmvlelNASDD----R 75
Cdd:PRK14958 6 LARKWRPRCFQEVIGQAPVVRALSNALDQQYLHHAYLFtGTRGVGKTTISRILAKCLNCEKGVSA-----NPCNDcencR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 76 GIDIIRGPIL---------SFASTRTIF--------KKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLS 138
Cdd:PRK14958 81 EIDEGRFPDLfevdaasrtKVEDTRELLdnipyaptKGRFKVYLIDEVHMLSGHSFNALLKTLEEPPSHVKFILATTDHH 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 139 KIIPALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTnMAFGkvteetvytcT 218
Cdd:PRK14958 161 KLPVTVLSRCLQFHLAQLPPLQIAAHCQHLLKEENVEFENAALDLLARAANGSVRDALSLLDQS-IAYG----------N 229
|
250
....*....|...
gi 194306567 219 GHPLKSDIANILD 231
Cdd:PRK14958 230 GKVLIADVKTMLG 242
|
|
| PRK09111 |
PRK09111 |
DNA polymerase III subunits gamma and tau; Validated |
4-214 |
1.01e-11 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236382 [Multi-domain] Cd Length: 598 Bit Score: 65.31 E-value: 1.01e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 4 KYRPQTLNDLISHQDILSTIQKFINEDRLPH-LLLYGPPGTGKTST--ILAcaKQL-YKDKEfGSM-------------- 65
Cdd:PRK09111 17 KYRPQTFDDLIGQEAMVRTLTNAFETGRIAQaFMLTGVRGVGKTTTarILA--RALnYEGPD-GDGgptidlcgvgehcq 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 66 ---------VLELNASDDRGIDIIRGPILSF----ASTRtifkkgFKLVILDEADAMTQDAQNALRRVIE------KF-- 124
Cdd:PRK09111 94 aimegrhvdVLEMDAASHTGVDDIREIIESVryrpVSAR------YKVYIIDEVHMLSTAAFNALLKTLEeppphvKFif 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 125 --TEntrfclicnyLSKI-IPALqSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMkALVTLSS-GDMRRALNIL- 199
Cdd:PRK09111 168 atTE----------IRKVpVTVL-SRCQRFDLRRIEADVLAAHLSRIAAKEGVEVEDEAL-ALIARAAeGSVRDGLSLLd 235
|
250
....*....|....*
gi 194306567 200 QSTNMAFGKVTEETV 214
Cdd:PRK09111 236 QAIAHGAGEVTAEAV 250
|
|
| PRK14948 |
PRK14948 |
DNA polymerase III subunit gamma/tau; |
4-214 |
1.06e-11 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237862 [Multi-domain] Cd Length: 620 Bit Score: 65.37 E-value: 1.06e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 4 KYRPQTLNDLISHQDILSTIQKFINEDRL-PHLLLYGPPGTGKTST--ILA---------------CAK-QLYKDKEFGS 64
Cdd:PRK14948 9 KYRPQRFDELVGQEAIATTLKNALISNRIaPAYLFTGPRGTGKTSSarILAkslnclnsdkptpepCGKcELCRAIAAGN 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 65 M--VLELNASDDRGIDIIRGPI--LSFAST--RtifkkgFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLS 138
Cdd:PRK14948 89 AldVIEIDAASNTGVDNIRELIerAQFAPVqaR------WKVYVIDECHMLSTAAFNALLKTLEEPPPRVVFVLATTDPQ 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194306567 139 KIIPALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTNMAFGKVTEETV 214
Cdd:PRK14948 163 RVLPTIISRCQRFDFRRIPLEAMVQHLSEIAEKESIEIEPEALTLVAQRSQGGLRDAESLLDQLSLLPGPITPEAV 238
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
4-199 |
1.98e-10 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 61.54 E-value: 1.98e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 4 KYRPQTLNDLI--SH-QDILSTIqkfINEDRLPHLLLY-GPPGTGKTST--ILA----CAK--------------QLYKD 59
Cdd:PRK07764 8 RYRPATFAEVIgqEHvTEPLSTA---LDSGRINHAYLFsGPRGCGKTSSarILArslnCVEgptstpcgecdscvALAPG 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 60 KEfGSM-VLELNASDDRGIDIIR--------GPilsfASTRtifkkgFKLVILDEADAMTQDAQNALRRVIE------KF 124
Cdd:PRK07764 85 GP-GSLdVTEIDAASHGGVDDARelreraffAP----AESR------YKIFIIDEAHMVTPQGFNALLKIVEeppehlKF 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 125 ----TENtrfclicnylSKIIPALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDIsEDGMKALVTLS-SGDMRRALNIL 199
Cdd:PRK07764 154 ifatTEP----------DKVIGTIRSRTHHYPFRLVPPEVMRGYLERICAQEGVPV-EPGVLPLVIRAgGGSVRDSLSVL 222
|
|
| AAA |
smart00382 |
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ... |
31-159 |
9.64e-10 |
|
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.
Pssm-ID: 214640 [Multi-domain] Cd Length: 148 Bit Score: 56.23 E-value: 9.64e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 31 RLPHLLLYGPPGTGKTSTILACAKQLYKDKEFgsmVLELNASDDRGIDIIRGPILSFASTRT--------------IFKK 96
Cdd:smart00382 1 PGEVILIVGPPGSGKTTLARALARELGPPGGG---VIYIDGEDILEEVLDQLLLIIVGGKKAsgsgelrlrlalalARKL 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 194306567 97 GFKLVILDEADAMTQDAQNALRRVIEKFT--------ENTRFCLICNYLSKIIPALQSRCTRFRFGPLTPE 159
Cdd:smart00382 78 KPDVLILDEITSLLDAEQEALLLLLEELRlllllkseKNLTVILTTNDEKDLGPALLRRRFDRRIVLLLIL 148
|
|
| PRK06645 |
PRK06645 |
DNA polymerase III subunits gamma and tau; Validated |
4-205 |
1.05e-09 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 180643 [Multi-domain] Cd Length: 507 Bit Score: 59.10 E-value: 1.05e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 4 KYRPQTLNDLISHQDILSTIQKFINEDRLPH-LLLYGPPGTGKTST--ILA----CAKQLYKDKEFGSM----------- 65
Cdd:PRK06645 14 KYRPSNFAELQGQEVLVKVLSYTILNDRLAGgYLLTGIRGVGKTTSarIIAkavnCSALITENTTIKTCeqctncisfnn 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 66 -----VLELNASDDRGIDIIRgPILSFASTRTIFKKgFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKI 140
Cdd:PRK06645 94 hnhpdIIEIDAASKTSVDDIR-RIIESAEYKPLQGK-HKIFIIDEVHMLSKGAFNALLKTLEEPPPHIIFIFATTEVQKI 171
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194306567 141 IPALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL-QSTNMA 205
Cdd:PRK06645 172 PATIISRCQRYDLRRLSFEEIFKLLEYITKQENLKTDIEALRIIAYKSEGSARDAVSILdQAASMS 237
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
4-276 |
1.29e-09 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 59.09 E-value: 1.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 4 KYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLY-GPPGTGKTSTILACAKQLY----------------KDKEFGSMV 66
Cdd:PRK07003 9 KWRPKDFASLVGQEHVVRALTHALDGGRLHHAYLFtGTRGVGKTTLSRIFAKALNcetgvtsqpcgvcracREIDEGRFV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 67 --LELNASDDRGIDIIrGPILSFASTRTIFKKgFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPAL 144
Cdd:PRK07003 89 dyVEMDAASNRGVDEM-AALLERAVYAPVDAR-FKVYMIDEVHMLTNHAFNAMLKTLEEPPPHVKFILATTDPQKIPVTV 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 145 QSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL-QSTNMAFGKVTEETVYTCTGHPLK 223
Cdd:PRK07003 167 LSRCLQFNLKQMPAGHIVSHLERILGEERIAFEPQALRLLARAAQGSMRDALSLTdQAIAYSANEVTETAVSGMLGALDQ 246
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 194306567 224 SDIANILDWMLNQDfTTAYRNITELKTLKGLALHDILTEIHLFVHRVDF----PSSV 276
Cdd:PRK07003 247 TYMVRLLDALAAGD-GPEILAVADEMALRSLSFSTALQDLASLLHRIAWaqfaPASV 302
|
|
| HLD_clamp |
cd18133 |
helical lid domain of clamp loader-like AAA+ proteins; Clamp loader complexes are multisubunit ... |
159-218 |
1.44e-09 |
|
helical lid domain of clamp loader-like AAA+ proteins; Clamp loader complexes are multisubunit complexes that play an important role in DNA replication. They open sliding clamps for assembly and close them around DNA, specifically targeting them to sites where DNA synthesis is initiated and orienting them correctly for replication. The subunits belong to the clamp loader clade of AAA+ superfamily.
Pssm-ID: 350838 [Multi-domain] Cd Length: 65 Bit Score: 53.63 E-value: 1.44e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 194306567 159 ELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNILQSTNMAF--GKVTEETVYTCT 218
Cdd:cd18133 4 EQLKRRLAAIAEQEKLKLDDAALQALAYISEGDLRKALNALQRAAALGddGKISLDRVYQAV 65
|
|
| PRK14957 |
PRK14957 |
DNA polymerase III subunits gamma and tau; Provisional |
1-302 |
2.53e-09 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 184921 [Multi-domain] Cd Length: 546 Bit Score: 58.17 E-value: 2.53e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 1 MVEKYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLY-GPPGTGKTSTILACAKQL-------------------YKDK 60
Cdd:PRK14957 6 LARKYRPQSFAEVAGQQHALNSLVHALETQKVHHAYLFtGTRGVGKTTLGRLLAKCLncktgvtaepcnkcencvaINNN 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 61 EFGSMVlELNASDDRGIDIIRgPILSfaSTRTIFKKG-FKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSK 139
Cdd:PRK14957 86 SFIDLI-EIDAASRTGVEETK-EILD--NIQYMPSQGrYKVYLIDEVHMLSKQSFNALLKTLEEPPEYVKFILATTDYHK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 140 IIPALQSRCTRFRFGPLTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL-QSTNMAFGKVTEETVYTCT 218
Cdd:PRK14957 162 IPVTILSRCIQLHLKHISQADIKDQLKIILAKENINSDEQSLEYIAYHAKGSLRDALSLLdQAISFCGGELKQAQIKQML 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 219 GHPLKSDIANILDWMLNQD---FTTAYRNITeLKTLKGLALHDILTE------IHLFVHRVDFPSSVRIHLLTKMAD--- 286
Cdd:PRK14957 242 GIIDSEEVYSIINAIIDNDpkaILPAIKNLA-LTESSADAVLDRIAEiwfaccIYSFTQSLDAVNDIDVDIINNILAkis 320
|
330 340
....*....|....*....|.
gi 194306567 287 IE-----YRLSVGTNEKIQLS 302
Cdd:PRK14957 321 IEqahflYQLTITAKKDIALA 341
|
|
| PRK04132 |
PRK04132 |
replication factor C small subunit; Provisional |
2-48 |
9.40e-09 |
|
replication factor C small subunit; Provisional
Pssm-ID: 235223 [Multi-domain] Cd Length: 846 Bit Score: 56.39 E-value: 9.40e-09
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 194306567 2 VEKYRPQTLNDLISHQDILSTIQKFINEDRLPHLLLYGPPGTGKTST 48
Cdd:PRK04132 10 VEKYRPQRLDDIVGQEHIVKRLKHYVKTGSMPHLLFAGPPGVGKCLT 56
|
|
| SpoVK |
COG0464 |
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ... |
2-159 |
2.24e-08 |
|
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 440232 [Multi-domain] Cd Length: 397 Bit Score: 54.92 E-value: 2.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 2 VEKYRPQTLNDLISHQDILSTIQKFINE----DRLP---------HLLLYGPPGTGKTSTILACAKQLykdkefGSMVLE 68
Cdd:COG0464 148 LLELREAILDDLGGLEEVKEELRELVALplkrPELReeyglppprGLLLYGPPGTGKTLLARALAGEL------GLPLIE 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 69 LNASDdrgidiIRGPIL--SFASTRTIFKK--GFKLVIL--DEADAM----TQDAQNALRRVIE---KFTENTRF--CLI 133
Cdd:COG0464 222 VDLSD------LVSKYVgeTEKNLREVFDKarGLAPCVLfiDEADALagkrGEVGDGVGRRVVNtllTEMEELRSdvVVI 295
|
170 180
....*....|....*....|....*....
gi 194306567 134 C--NYLSKIIPALQSRCTR-FRFGPLTPE 159
Cdd:COG0464 296 AatNRPDLLDPALLRRFDEiIFFPLPDAE 324
|
|
| PRK06964 |
PRK06964 |
DNA polymerase III subunit delta'; Validated |
30-166 |
5.99e-08 |
|
DNA polymerase III subunit delta'; Validated
Pssm-ID: 235898 [Multi-domain] Cd Length: 342 Bit Score: 53.23 E-value: 5.99e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 30 DRLPH-LLLYGPPGTGKTSTILACAKQL----------------------------YK--------DKEFGSMVLELNAS 72
Cdd:PRK06964 18 ARLPHaLLLHGQAGIGKLDFAQHLAQGLlcetpqpdgepcgtcaacnwfaqgnhpdYRivrpealaAEAPGAADEAKEAD 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 73 DDRG------------IDIIRGpILSFASTRTiFKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKI 140
Cdd:PRK06964 98 ADEGgkktkapskeikIEQVRA-LLDFCGVGT-HRGGARVVVLYPAEALNVAAANALLKTLEEPPPGTVFLLVSARIDRL 175
|
170 180
....*....|....*....|....*.
gi 194306567 141 IPALQSRCTRFRFGPLTPELMVPRLE 166
Cdd:PRK06964 176 LPTILSRCRQFPMTVPAPEAAAAWLA 201
|
|
| PRK07399 |
PRK07399 |
DNA polymerase III subunit delta'; Validated |
77-201 |
1.28e-07 |
|
DNA polymerase III subunit delta'; Validated
Pssm-ID: 236011 [Multi-domain] Cd Length: 314 Bit Score: 52.21 E-value: 1.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 77 IDIIRGpILSFASTRTIFKKGfKLVILDEADAMTQDAQNALRRVIEKfTENTRFCLICNYLSKIIPALQSRCTRFRFGPL 156
Cdd:PRK07399 106 LEQIRE-IKRFLSRPPLEAPR-KVVVIEDAETMNEAAANALLKTLEE-PGNGTLILIAPSPESLLPTIVSRCQIIPFYRL 182
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 194306567 157 TPELMVPRLEHVVEEEKVDISedgMKALVTLSSGDMRRAL---NILQS 201
Cdd:PRK07399 183 SDEQLEQVLKRLGDEEILNIN---FPELLALAQGSPGAAIaniEQLQS 227
|
|
| ruvB |
PRK00080 |
Holliday junction branch migration DNA helicase RuvB; |
6-51 |
2.92e-07 |
|
Holliday junction branch migration DNA helicase RuvB;
Pssm-ID: 234619 [Multi-domain] Cd Length: 328 Bit Score: 51.28 E-value: 2.92e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 194306567 6 RPQTLNDLISHQDILSTIQKFIN-----EDRLPHLLLYGPPGTGKTS--TILA 51
Cdd:PRK00080 20 RPKSLDEFIGQEKVKENLKIFIEaakkrGEALDHVLLYGPPGLGKTTlaNIIA 72
|
|
| PRK06090 |
PRK06090 |
DNA polymerase III subunit delta'; Validated |
97-162 |
3.04e-07 |
|
DNA polymerase III subunit delta'; Validated
Pssm-ID: 180394 [Multi-domain] Cd Length: 319 Bit Score: 50.96 E-value: 3.04e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194306567 97 GFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPLTPELMV 162
Cdd:PRK06090 108 GYRLFVIEPADAMNESASNALLKTLEEPAPNCLFLLVTHNQKRLLPTIVSRCQQWVVTPPSTAQAM 173
|
|
| HLD_clamp_pol_III_gamma_tau |
cd18137 |
helical lid domain of DNA polymerase III subunits gamma and tau; DNA polymerase III subunit ... |
156-219 |
3.36e-07 |
|
helical lid domain of DNA polymerase III subunits gamma and tau; DNA polymerase III subunit gamma/tau is part of the DNA polymerase III holoenzyme. Gamma and tau subunits are isoforms, both containing the helical lid domain. Gamma interacts with the delta subunit to transfer the beta subunit on the DNA while tau serves as a scaffold to help in the dimerization of the core complex. Both are members of the clamp-loader clade of the AAA+ superfamily.
Pssm-ID: 350839 [Multi-domain] Cd Length: 65 Bit Score: 46.73 E-value: 3.36e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194306567 156 LTPELMVPRLEHVVEEEKVDISEDGMKALVTLSSGDMRRALNIL-QSTNMAFGKVTEETVYTCTG 219
Cdd:cd18137 1 ISVEDIVGRLAHILEKEGIEIEDEALELIARAAEGSMRDALSLLdQAIAFGGGRVTLDDVREMLG 65
|
|
| Rad17 |
pfam03215 |
Rad17 P-loop domain; |
2-56 |
4.81e-07 |
|
Rad17 P-loop domain;
Pssm-ID: 367398 [Multi-domain] Cd Length: 186 Bit Score: 49.19 E-value: 4.81e-07
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 2 VEKYRPQTLNDLISHQDILSTIQKFINEDRLPH-----LLLYGPPGTGKTSTILACAKQL 56
Cdd:pfam03215 10 YEKYKPNCLEQLAVHKRKIKDVQEWLDAMFLENakhriLLISGPSGCGKSTVIKELSKEL 69
|
|
| DEXXQc_Helz-like |
cd18038 |
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and ... |
31-58 |
1.03e-06 |
|
DEXXQ/H-box helicase domain of Helz-like helicase; This subfamily contains HELZ, Mov10L1, and similar proteins. Helicase with zinc finger (HELZ) acts as a helicase that plays a role in RNA metabolism during development. Moloney leukemia virus 10-like protein 1 (Mov10L1) binds Piwi-interacting RNA (piRNA) precursors to initiate piRNA processing. All are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350796 [Multi-domain] Cd Length: 229 Bit Score: 48.77 E-value: 1.03e-06
10 20
....*....|....*....|....*...
gi 194306567 31 RLPHLLLYGPPGTGKTSTILACAKQLYK 58
Cdd:cd18038 19 RPPPYIIFGPPGTGKTVTLVEAILQVLR 46
|
|
| RecA-like_protease |
cd19481 |
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of ... |
35-151 |
1.27e-06 |
|
proteases similar to RecA; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.
Pssm-ID: 410889 [Multi-domain] Cd Length: 158 Bit Score: 47.66 E-value: 1.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 35 LLLYGPPGTGKTSTILACAKQLykDKEFgsmvleLNASDDRGIDIIRGPilSFASTRTIF----KKGFKLVILDEADAM- 109
Cdd:cd19481 29 ILLYGPPGTGKTLLAKALAGEL--GLPL------IVVKLSSLLSKYVGE--SEKNLRKIFerarRLAPCILFIDEIDAIg 98
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 194306567 110 -----------TQDAQNALRRVIEKFTENTRFCLIC--NYLSKIIPALQsRCTRF 151
Cdd:cd19481 99 rkrdssgesgeLRRVLNQLLTELDGVNSRSKVLVIAatNRPDLLDPALL-RPGRF 152
|
|
| RuvB_N |
pfam05496 |
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the ... |
6-51 |
1.88e-06 |
|
Holliday junction DNA helicase RuvB P-loop domain; The RuvB protein makes up part of the RuvABC revolvasome which catalyzes the resolution of Holliday junctions that arise during genetic recombination and DNA repair. Branch migration is catalyzed by the RuvB protein that is targeted to the Holliday junction by the structure specific RuvA protein. This family contains the N-terminal region of the protein.
Pssm-ID: 398900 [Multi-domain] Cd Length: 159 Bit Score: 47.11 E-value: 1.88e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 194306567 6 RPQTLNDLISHQDILSTIQKFIN-----EDRLPHLLLYGPPGTGKT--STILA 51
Cdd:pfam05496 2 RPRTLDEYIGQEKVKENLKIFIEaakqrGEALDHVLLYGPPGLGKTtlANIIA 54
|
|
| RuvB |
COG2255 |
Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, ... |
6-51 |
2.17e-06 |
|
Holliday junction resolvasome RuvABC, ATP-dependent DNA helicase subunit RuvB [Replication, recombination and repair];
Pssm-ID: 441856 [Multi-domain] Cd Length: 337 Bit Score: 48.54 E-value: 2.17e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 194306567 6 RPQTLNDLISHQDILSTIQKFIN-----EDRLPHLLLYGPPGTGKT--STILA 51
Cdd:COG2255 23 RPKRLDEYIGQEKVKENLKIFIEaakkrGEALDHVLLYGPPGLGKTtlAHIIA 75
|
|
| ruvB |
TIGR00635 |
Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions ... |
8-199 |
3.16e-06 |
|
Holliday junction DNA helicase, RuvB subunit; All proteins in this family for which functions are known are 5'-3' DNA helicases that, as part of a complex with RuvA homologs serve as a 5'-3' Holliday junction helicase. RuvA specifically binds Holliday junctions as a sandwich of two tetramers and maintains the configuration of the junction. It forms a complex with two hexameric rings of RuvB, the subunit that contains helicase activity. The complex drives ATP-dependent branch migration of the Holliday junction recombination intermediate. The endonuclease RuvC resolves junctions. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 129721 [Multi-domain] Cd Length: 305 Bit Score: 48.07 E-value: 3.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 8 QTLNDLISHQDILSTIQKFI-----NEDRLPHLLLYGPPGTGKTS--TILACakqlykdkefgsmvlELNASddrgIDII 80
Cdd:TIGR00635 1 KLLAEFIGQEKVKEQLQLFIeaakmRQEALDHLLLYGPPGLGKTTlaHIIAN---------------EMGVN----LKIT 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 81 RGPIL----SFASTRTIFKKGFKLVIlDEADAMTQDAQNALRRVIEKFT----------------ENTRFCLI--CNYLS 138
Cdd:TIGR00635 62 SGPALekpgDLAAILTNLEEGDVLFI-DEIHRLSPAVEELLYPAMEDFRldivigkgpsarsvrlDLPPFTLVgaTTRAG 140
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194306567 139 KIIPALQSrctrfRFGpltpelMVPRLEHVVEEE------------KVDISEDGMKALVTLSSGDMRRALNIL 199
Cdd:TIGR00635 141 MLTSPLRD-----RFG------IILRLEFYTVEElaeivsrsagllNVEIEPEAALEIARRSRGTPRIANRLL 202
|
|
| COG1223 |
COG1223 |
Predicted ATPase, AAA+ superfamily [General function prediction only]; |
10-196 |
5.00e-06 |
|
Predicted ATPase, AAA+ superfamily [General function prediction only];
Pssm-ID: 440836 [Multi-domain] Cd Length: 246 Bit Score: 46.80 E-value: 5.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 10 LNDLISHQDILSTIQKFINE----DRL--------PHLLLYGPPGTGKTSTILACAKQLykdkefGSMVLELNASddrgi 77
Cdd:COG1223 1 LDDVVGQEEAKKKLKLIIKElrrrENLrkfglwppRKILFYGPPGTGKTMLAEALAGEL------KLPLLTVRLD----- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 78 diirGPILSF-----ASTRTIFK--KGFKLVI-LDEADAMTQD--AQNA---LRRVIEKF-----TENTRFCLIC--NYL 137
Cdd:COG1223 70 ----SLIGSYlgetaRNLRKLFDfaRRAPCVIfFDEFDAIAKDrgDQNDvgeVKRVVNALlqeldGLPSGSVVIAatNHP 145
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194306567 138 SKIIPALQSRC-TRFRFGPLTPELMVPRLEHVVEEEKVDISEDGM---KALVTLSSGDMRRAL 196
Cdd:COG1223 146 ELLDSALWRRFdEVIEFPLPDKEERKEILELNLKKFPLPFELDLKklaKKLEGLSGADIEKVL 208
|
|
| AAA_24 |
pfam13479 |
AAA domain; This AAA domain is found in a wide variety of presumed phage proteins. |
35-130 |
6.97e-06 |
|
AAA domain; This AAA domain is found in a wide variety of presumed phage proteins.
Pssm-ID: 433243 Cd Length: 199 Bit Score: 46.17 E-value: 6.97e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 35 LLLYGPPGTGKTSTILACAKQLYKDKEFGSMVLElnasDDRGIDI-IRGPILSF----ASTRTIFKKGFKLVILDEADAM 109
Cdd:pfam13479 5 ILIYGPSGIGKTTFAKTLPKPLFLDTEKGSKALD----GDRFPDIvIRDSWQDFldaiDELTAAELADYKTIVIDTVDWL 80
|
90 100
....*....|....*....|.
gi 194306567 110 TQDAQNALRRVIEKFTENTRF 130
Cdd:pfam13479 81 ERLCLAYICKQNGKGSSIEDG 101
|
|
| PRK07994 |
PRK07994 |
DNA polymerase III subunits gamma and tau; Validated |
146-214 |
7.82e-06 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236138 [Multi-domain] Cd Length: 647 Bit Score: 47.17 E-value: 7.82e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194306567 146 SRCTRFRFGPLTPELMVPRLEHVVEEEKVDiSEDgmKALVTLS---SGDMRRALNIL-QSTNMAFGKVTEETV 214
Cdd:PRK07994 168 SRCLQFHLKALDVEQIRQQLEHILQAEQIP-FEP--RALQLLAraaDGSMRDALSLTdQAIASGNGQVTTDDV 237
|
|
| CDC6 |
COG1474 |
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair]; |
17-199 |
1.11e-05 |
|
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
Pssm-ID: 441083 [Multi-domain] Cd Length: 389 Bit Score: 46.38 E-value: 1.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 17 QDILSTIQKFINEDRLPHLLLYGPPGTGKTSTILACAKQLYKD-KEFGSMV--LELNASDDR---GI------DIIRGPI 84
Cdd:COG1474 36 EELASALRPALRGERPSNVLIYGPTGTGKTAVAKYVLEELEEEaEERGVDVrvVYVNCRQAStryRVlsrileELGSGED 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 85 LSF--ASTRTIFKKGFK---------LVILDEADAMTQDAQN----ALRRVIEKFtENTRFCLIC-----NYLSKIIPAL 144
Cdd:COG1474 116 IPStgLSTDELFDRLYEalderdgvlVVVLDEIDYLVDDEGDdllyQLLRANEEL-EGARVGVIGisndlEFLENLDPRV 194
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194306567 145 QSR--CTRFRFGPLT-PEL---MVPRLEH-----VVEEEKVD-ISedgmkALVTLSSGDMRRALNIL 199
Cdd:COG1474 195 KSSlgEEEIVFPPYDaDELrdiLEDRAELafydgVLSDEVIPlIA-----ALAAQEHGDARKAIDLL 256
|
|
| PRK07993 |
PRK07993 |
DNA polymerase III subunit delta'; Validated |
97-201 |
1.24e-05 |
|
DNA polymerase III subunit delta'; Validated
Pssm-ID: 181190 [Multi-domain] Cd Length: 334 Bit Score: 46.21 E-value: 1.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 97 GFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRFGPLTPELMVPRLEHvveeeKVDI 176
Cdd:PRK07993 108 GAKVVWLPDAALLTDAAANALLKTLEEPPENTWFFLACREPARLLATLRSRCRLHYLAPPPEQYALTWLSR-----EVTM 182
|
90 100
....*....|....*....|....*
gi 194306567 177 SEDGMKALVTLSSGDMRRALNILQS 201
Cdd:PRK07993 183 SQDALLAALRLSAGAPGAALALLQP 207
|
|
| AAA_assoc_2 |
pfam16193 |
AAA C-terminal domain; AAA_assoc_2 is found at the C-terminus of a relatively small set of AAA ... |
170-214 |
1.46e-05 |
|
AAA C-terminal domain; AAA_assoc_2 is found at the C-terminus of a relatively small set of AAA domains in proteins ranging from archaeal to fungi, plants and mammals.
Pssm-ID: 465057 Cd Length: 81 Bit Score: 42.46 E-value: 1.46e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 194306567 170 EEEKVDISEDGMKALVTLSSGDMRRALNIL----QSTNMAFGK--VTEETV 214
Cdd:pfam16193 1 GGLKIELDDEALEALAELADGDARRALNALelavLSTPPDDGGihITLEIL 51
|
|
| PRK08699 |
PRK08699 |
DNA polymerase III subunit delta'; Validated |
30-151 |
1.68e-05 |
|
DNA polymerase III subunit delta'; Validated
Pssm-ID: 181538 [Multi-domain] Cd Length: 325 Bit Score: 46.02 E-value: 1.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 30 DRLPH-LLLYGPPGTGKTSTILACAKQLYKDKE---------------FGS-------MVLELNASDDRG-------IDI 79
Cdd:PRK08699 18 ERRPNaWLFAGKKGIGKTAFARFAAQALLCETPapghkpcgecmschlFGQgshpdfyEITPLSDEPENGrkllqikIDA 97
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 194306567 80 IRgPILSFASTrTIFKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRF 151
Cdd:PRK08699 98 VR-EIIDNVYL-TSVRGGLRVILIHPAESMNLQAANSLLKVLEEPPPQVVFLLVSHAADKVLPTIKSRCRKM 167
|
|
| HLD_clamp_RarA |
cd18139 |
helical lid domain of recombination factor protein RarA; Recombination factor RarA ... |
156-200 |
1.65e-04 |
|
helical lid domain of recombination factor protein RarA; Recombination factor RarA (Replication associated recombination gene/protein A, also known as MgsA (Maintenance of genome stability A) or Mgs1 in yeast and WRNIP1 in mammals) is a member of the clamp-loader clade of the AAA+ superfamily. It functions as a tetramer. RarA co-localize with the replication fork throughout the cell cycle and may play a role in the rescue of stalled replication forks.
Pssm-ID: 350841 [Multi-domain] Cd Length: 75 Bit Score: 39.54 E-value: 1.65e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 194306567 156 LTPELMVPRLEHVVEEE------KVDISEDGMKALVTLSSGDMRRALNILQ 200
Cdd:cd18139 1 LSEEDLEKLLKRALEDKerggdrKVTIDDEALELLAEAADGDARSALNLLE 51
|
|
| RecA-like_BCS1 |
cd19510 |
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of ... |
19-56 |
4.53e-04 |
|
Mitochondrial chaperone BCS1; Mitochondrial chaperone BCS1 is necessary for the assembly of mitochondrial respiratory chain complex III and plays an important role in the maintenance of mitochondrial tubular networks, respiratory chain assembly and formation of the LETM1 complex. RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.
Pssm-ID: 410918 [Multi-domain] Cd Length: 153 Bit Score: 40.03 E-value: 4.53e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 194306567 19 ILSTIQKFIN-----EDRLPH----LLLYGPPGTGKTSTILACAKQL 56
Cdd:cd19510 1 IIDDLKDFIKnedwyNDRGIPyrrgYLLYGPPGTGKSSFIAALAGEL 47
|
|
| COG2842 |
COG2842 |
Bacteriophage DNA transposition protein, AAA+ family ATPase [Mobilome: prophages, transposons]; ... |
36-214 |
5.08e-04 |
|
Bacteriophage DNA transposition protein, AAA+ family ATPase [Mobilome: prophages, transposons];
Pssm-ID: 442090 [Multi-domain] Cd Length: 254 Bit Score: 41.09 E-value: 5.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 36 LLYGPPGTGKTSTILACAKQ-----------LYKDKEF-GSMVLELNASDDRG--IDIIRGPILSFASTRTifkkgfkLV 101
Cdd:COG2842 54 VVYGESGVGKTTAAREYANRnpnviyvtaspSWTSKELlEELAEELGIPAPPGtiADLRDRILERLAGTGR-------LL 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 102 ILDEADAMTQDAQNALRRVIEKftENTRFCLICN--YLSKI--IPALQSRCT-RFRFGPLTPE---LMVPRLEHVVEEEK 173
Cdd:COG2842 127 IIDEADHLKPKALEELRDIHDE--TGVGVVLIGMerLPAKLkrYEQLYSRIGfWVEFKPLSLEdvrALAEAWGELTDPDL 204
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 194306567 174 VdisedgmKALVTLSSGDMRRALNIL-----QSTNMAFGKVTEETV 214
Cdd:COG2842 205 L-------ELLHRITRGNLRRLDRTLrlaarAAKRNGLTKITLDHV 243
|
|
| T7SS_EccA |
TIGR03922 |
type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the ... |
34-200 |
5.43e-04 |
|
type VII secretion AAA-ATPase EccA; This model represents the AAA family ATPase, EccA, of the actinobacterial flavor of type VII secretion systems. Species such as Mycobacterium tuberculosis have several instances of this system per genome, designated EccA1, EccA2, etc. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 188437 [Multi-domain] Cd Length: 557 Bit Score: 41.37 E-value: 5.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 34 HLLLYGPPGTGKTSTILACAKQLYkdkefgsmvlelnasddrGIDIIRGPIL---------------SFASTRTIFKKGF 98
Cdd:TIGR03922 314 HMLFAGPPGTGKTTIARVVAKIYC------------------GLGVLRKPLVrevsradligqyigeSEAKTNEIIDSAL 375
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 99 KLVI-LDEADAMTQ-----------DAQNALRRVIEkfTENTRFCLICNYLSKII-------PALQSRCTR-FRFGPLTP 158
Cdd:TIGR03922 376 GGVLfLDEAYTLVEtgygqkdpfglEAIDTLLARME--NDRDRLVVIGAGYRKDLdkflevnEGLRSRFTRvIEFPSYSP 453
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 194306567 159 ELMVpRLEHVVEEEKVDISEDG-----MKALVTLS-------SGDMRRALNILQ 200
Cdd:TIGR03922 454 DELV-EIARRMATERDSVLDDAaadalLEAATTLAqdttpdaNGDLRRGLDIAG 506
|
|
| RecA-like_NSF-SEC18_r1-like |
cd19504 |
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; ... |
35-109 |
1.21e-03 |
|
first of two ATPase domains of NSF and SEC18, and similar ATPase domains; N-ethylmaleimide-sensitive factor (NSF) and Saccharomyces cerevisiae Vesicular-fusion protein Sec18, key factors for eukaryotic trafficking, are ATPases and SNARE disassembly chaperones. NSF/Sec18 activate or prime SNAREs, the terminal catalysts of membrane fusion. Sec18/NSF associates with SNARE complexes through binding Sec17/alpha-SNAP. Sec18 has an N-terminal cap domain and two nucleotide-binding domains (D1 and D2) which form the two rings of the hexameric complex. The hydrolysis of ATP by D1 generates most of the energy necessary to disassemble inactive SNARE bundles, while the D2 ring binds ATP to stabilize the homohexamer. This subfamily includes the first (D1) ATPase domain of NSF/Sec18, and belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.
Pssm-ID: 410912 [Multi-domain] Cd Length: 177 Bit Score: 39.01 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 35 LLLYGPPGTGKTstilACAKQLykdkefGSMvleLNASDDRgidIIRGP-IL------SFASTRTIFK------------ 95
Cdd:cd19504 38 ILLYGPPGTGKT----LMARQI------GKM---LNAREPK---IVNGPeILnkyvgeSEANIRKLFAdaeeeqrrlgan 101
|
90
....*....|....
gi 194306567 96 KGFKLVILDEADAM 109
Cdd:cd19504 102 SGLHIIIFDEIDAI 115
|
|
| PRK06871 |
PRK06871 |
DNA polymerase III subunit delta'; Validated |
74-148 |
2.28e-03 |
|
DNA polymerase III subunit delta'; Validated
Pssm-ID: 180738 [Multi-domain] Cd Length: 325 Bit Score: 39.33 E-value: 2.28e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194306567 74 DRGIDIIR---GPILSFAStrtifKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRC 148
Cdd:PRK06871 86 DIGVDQVReinEKVSQHAQ-----QGGNKVVYIQGAERLTEAAANALLKTLEEPRPNTYFLLQADLSAALLPTIYSRC 158
|
|
| AAA_11 |
pfam13086 |
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA ... |
23-58 |
2.48e-03 |
|
AAA domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.
Pssm-ID: 404072 [Multi-domain] Cd Length: 248 Bit Score: 38.86 E-value: 2.48e-03
10 20 30
....*....|....*....|....*....|....*.
gi 194306567 23 IQKFINEDRLphLLLYGPPGTGKTSTILACAKQLYK 58
Cdd:pfam13086 6 IRSALSSSHF--TLIQGPPGTGKTTTIVELIRQLLS 39
|
|
| RecA-like_CDC48_NLV2_r1-like |
cd19503 |
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and ... |
35-110 |
3.58e-03 |
|
first of two ATPase domains of CDC48 and NLV2, and similar ATPase domains; CDC48 in yeast and p97 or VCP metazoans is an ATP-dependent molecular chaperone which plays an essential role in many cellular processes, by segregating polyubiquitinated proteins from complexes or membranes. Cdc48/p97 consists of an N-terminal domain and two ATPase domains; this subfamily represents the first of the two ATPase domains. This subfamily also includes the first of the two ATPase domains of NVL (nuclear VCP-like protein) 2, an isoform of NVL mainly present in the nucleolus, which is involved in ribosome biogenesis, in telomerase assembly and the regulation of telomerase activity, and in pre-rRNA processing. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.
Pssm-ID: 410911 [Multi-domain] Cd Length: 165 Bit Score: 37.66 E-value: 3.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 35 LLLYGPPGTGKTSTILACAKQLykdkefGSMVLELNasddrGIDIIRG-PILSFASTRTIFKKGFK----LVILDEADAM 109
Cdd:cd19503 37 VLLHGPPGTGKTLLARAVANEA------GANFLSIS-----GPSIVSKyLGESEKNLREIFEEARShapsIIFIDEIDAL 105
|
.
gi 194306567 110 T 110
Cdd:cd19503 106 A 106
|
|
| PRK07132 |
PRK07132 |
DNA polymerase III subunit delta'; Validated |
99-153 |
3.74e-03 |
|
DNA polymerase III subunit delta'; Validated
Pssm-ID: 180855 [Multi-domain] Cd Length: 299 Bit Score: 38.55 E-value: 3.74e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 194306567 99 KLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRCTRFRF 153
Cdd:PRK07132 92 KILIIKNIEKTSNSLLNALLKTIEEPPKDTYFLLTTKNINKVLPTIVSRCQVFNV 146
|
|
| AAA_16 |
pfam13191 |
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ... |
27-60 |
4.34e-03 |
|
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.
Pssm-ID: 433025 [Multi-domain] Cd Length: 167 Bit Score: 37.48 E-value: 4.34e-03
10 20 30
....*....|....*....|....*....|....
gi 194306567 27 INEDRLPHLLLYGPPGTGKTSTILACAKQLYKDK 60
Cdd:pfam13191 19 VRSGRPPSVLLTGEAGTGKTTLLRELLRALERDG 52
|
|
| RecA-like_Pch2-like |
cd19508 |
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as ... |
13-71 |
4.42e-03 |
|
ATPase domain of Pachytene checkpoint 2 (Pch2) and similar ATPase domains; Pch2 (known as Thyroid hormone receptor interactor 13 (TRIP13) and 16E1BP) is a key regulator of specific chromosomal events, like the control of G2/prophase processes such as DNA break formation and recombination, checkpoint signaling, and chromosome synapsis. This subfamily belongs to the RecA-like NTPase family which includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. The RecA-like NTPase family also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion
Pssm-ID: 410916 [Multi-domain] Cd Length: 199 Bit Score: 37.81 E-value: 4.42e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 194306567 13 LISHQDILSTIqkfINEDRLphLLLYGPPGTGKTSTILACAKQL---YKDKEFGSMVLELNA 71
Cdd:cd19508 38 LFSDKNVNTNL---ITWNRL--VLLHGPPGTGKTSLCKALAQKLsirLSSRYRYGQLIEINS 94
|
|
| NACHT |
COG5635 |
Predicted NTPase, NACHT family domain [Signal transduction mechanisms]; |
3-159 |
4.61e-03 |
|
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
Pssm-ID: 444362 [Multi-domain] Cd Length: 935 Bit Score: 38.63 E-value: 4.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 3 EKYRPQTLNDLISHQDILSTIqkfinEDRLPHLLLYGPPGTGKTSTILACAKQLYKDKEFGS----MVLELN--ASDDRG 76
Cdd:COG5635 156 DLYVPLNLLERIESLKRLELL-----EAKKKRLLILGEPGSGKTTLLRYLALELAERYLDAEdpipILIELRdlAEEASL 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 77 IDIIRGPILSFAST-----RTIFKKGFKLVILD-----EADAMTQDAQNALRRVIEKFtENTRFCLICNYLSKIIPALQs 146
Cdd:COG5635 231 EDLLAEALEKRGGEpedalERLLRNGRLLLLLDgldevPDEADRDEVLNQLRRFLERY-PKARVIITSRPEGYDSSELE- 308
|
170
....*....|...
gi 194306567 147 RCTRFRFGPLTPE 159
Cdd:COG5635 309 GFEVLELAPLSDE 321
|
|
| PRK06581 |
PRK06581 |
DNA polymerase III subunit delta'; Validated |
72-148 |
5.55e-03 |
|
DNA polymerase III subunit delta'; Validated
Pssm-ID: 235833 [Multi-domain] Cd Length: 263 Bit Score: 37.90 E-value: 5.55e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194306567 72 SDDRGIDIIRGPILSFASTRTIFKKGFKLVILDEADAMTQDAQNALRRVIEKFTENTRFCLICNYLSKIIPALQSRC 148
Cdd:PRK06581 64 SNAKNISIEQIRKLQDFLSKTSAISGYKVAIIYSAELMNLNAANSCLKILEDAPKNSYIFLITSRAASIISTIRSRC 140
|
|
| DEXXQc_Upf1-like |
cd17934 |
DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, ... |
35-56 |
6.12e-03 |
|
DEXXQ-box helicase domain of Upf1-like helicase; The Upf1-like helicase family includes UPF1, HELZ, Mov10L1, Aquarius, IGHMBP2 (SMUBP2), coronavirus Nsp13, and similar proteins. They belong to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438708 [Multi-domain] Cd Length: 121 Bit Score: 36.06 E-value: 6.12e-03
|
| DEXXQc_SETX |
cd18042 |
DEXXQ-box helicase domain of SETX; The RNA/DNA helicase senataxin (SETX) plays a role in ... |
36-51 |
6.73e-03 |
|
DEXXQ-box helicase domain of SETX; The RNA/DNA helicase senataxin (SETX) plays a role in transcription, neurogenesis, and antiviral response. SEXT is an R-loop-associated protein that is thought to function as an RNA/DNA helicase. R-loops consist of RNA/DNA hybrids, formed during transcription when nascent RNA hybridizes to the DNA template strand, displacing the non-template DNA strand. Mutations in SETX are linked to two neurodegenerative disorders: ataxia with oculomotor apraxia type 2 (AOA2) and amyotrophic lateral sclerosis type 4 (ALS4). S. cerevisiae homolog splicing endonuclease 1 (Sen1) is an exclusively nuclear protein, important for nucleolar organization. S. cerevisiae Sen1 and its ortholog, the Schizosaccharomyces pombe Sen1, share conserved domains and belong to the family I class of helicases. Both proteins translocate 5' to 3' and unwind both DNA and RNA duplexes and also RNA/DNA hybrids in vitro. SETX is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438712 [Multi-domain] Cd Length: 218 Bit Score: 37.19 E-value: 6.73e-03
|
| AAA_5 |
pfam07728 |
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ... |
34-122 |
6.80e-03 |
|
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.
Pssm-ID: 400191 [Multi-domain] Cd Length: 135 Bit Score: 36.12 E-value: 6.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194306567 34 HLLLYGPPGTGKTSTILACAKQLYKDKEFgsMVL---ELNASDDRGIDIIRGPILSF--ASTRTIFKKGfKLVILDEADA 108
Cdd:pfam07728 1 GVLLVGPPGTGKTELAERLAAALSNRPVF--YVQltrDTTEEDLFGRRNIDPGGASWvdGPLVRAAREG-EIAVLDEINR 77
|
90
....*....|....
gi 194306567 109 MTQDAQNALRRVIE 122
Cdd:pfam07728 78 ANPDVLNSLLSLLD 91
|
|
| RPT1 |
COG1222 |
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein ... |
35-56 |
7.20e-03 |
|
ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440835 [Multi-domain] Cd Length: 326 Bit Score: 37.68 E-value: 7.20e-03
|
| AAA_7 |
pfam12775 |
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 ... |
34-71 |
9.98e-03 |
|
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the third nucleotide binding sites in the dynein motor. However, AAA3 has lost the catalytic residues necessary for ATP hydrolysis (the Walker B glutamate, the arginine finger, sensor-I and sensor-II motifs).
Pssm-ID: 463698 [Multi-domain] Cd Length: 179 Bit Score: 36.22 E-value: 9.98e-03
10 20 30
....*....|....*....|....*....|....*...
gi 194306567 34 HLLLYGPPGTGKTSTILACAKQLYKDKeFGSMVLELNA 71
Cdd:pfam12775 33 PVLLVGPTGTGKTVIIQNLLRKLDKEK-YLPLFINFSA 69
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