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Conserved domains on  [gi|194272180|ref|NP_001123554|]
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plexin-B1 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Plexin_cytopl pfam08337
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
 1562-2097 0e+00

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


:

Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 881.15  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  1562 GIPFLDYKVYAERIFFPGHRESPLHRDLGVP---ESRRPTVEQGLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVA 1638
Cdd:pfam08337    1 GIPFLDYRTYAMRVLFPGVEDHPLLVLLDVPvtnDGRRTNVEQALTQFSQLLNNKLFLLTFIRTLESQRSFSIRDRCNVA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  1639 SLLTVALHGKLEYFTDILRTLLSDLVAQYV-AKNPKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQ 1717
Cdd:pfam08337   81 SLLMVALHGKLEYATEILKTLLRDLIDKSVeSKNPKLLLRRTESVVEKMLTNWMSICLYPFLRECAGEPLFLLYKAIKQQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  1718 VDKGPVDSVTGKAKYTLNDNRLLREDVEYRPLTLNALLAVGpgaGEAQGVPVKVLDCDTISQAKEKMLDQLYKGVPLTQR 1797
Cdd:pfam08337  161 VEKGPVDAITGKARYTLSEDKLLREQIDYKTLTLHVIFEEG---ENSESVPVKVLDCDTITQVKEKILDAIYKNTPYSQR 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  1798 PDPRTLDVEWRSGVAGHLILSDEDVTSEVQGLWRRLNTLQHYKVPDGATVALVPcltkhvlrenqdyvpgertpmledvd 1877
Cdd:pfam08337  238 PSIDEVDLEWRHGRGGRLTLQDEDSTSKVEGGWKKLNTLAHYKVPDGATLALIP-------------------------- 291

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  1878 eggiRPWHLVKPSDEPEPprprrgslRGGERERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILST-SRPVPLAVKYFFD 1956
Cdd:pfam08337  292 ----KYWHLVKPSDEGDQ--------RKKSERRKKAIPEIYLTRLLSTKGTLQKFVDDLFESILSVpNSALPLAVKYLFD 359

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  1957 LLDEQAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINKL 2036
Cdd:pfam08337  360 FLDEQAEKHGITDPEVLHIWKSNSLPLRFWVNIIKNPQFVFDINKSPIVDSCLSVIAQTFMDSCSTSEHRLGKDSPSNKL 439

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 194272180  2037 LYARDIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINK 2097
Cdd:pfam08337  440 LYAKDIPRYKQMVERYYKDISNMPPISDQEMNAFLAEESRKHQNEFNTSAALKELYKYVNK 500
Sema_plexin_B1 cd11275
The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the ...
 28-480 0e+00

The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D-plexin B signaling complex regulates dendritic and axonal complexity. The activation of Plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


:

Pssm-ID: 200536 [Multi-domain]  Cd Length: 461  Bit Score: 855.80  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   28 FTPNGTYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDECPQAQPTNNPNQLLLVSPG- 106
Cdd:cd11275     1 FSPNGTKFLHLSMDPESGTLYLGATNFLFQLTPDLLLENMVQTGPVLDSKDCLPPVSKLECPQAQHTNNHNKLLLVNPVq 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  107 -ALVVCGSVHQGVCEQRRLGQLEQLLLRPERPGDTQYVAANDPAVSTVGLVAQGLAGEPLLFVGRGYTSRGVGGGIPPIT 185
Cdd:cd11275    81 kELIVCGSVHQGICEKRRLGSIDHVLFRPERPGDTQYVAANDPNVTTVGLVAYSKDGVPLLFVGRGYTSRGVGGGIPPIT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  186 TRALWPP-----DPQAAFSYEETAKLAVGRLSEYSHHFVSAFARGASAYFLFLRRDLQAQSRAFRAYVSRVCLRDQHYYS 260
Cdd:cd11275   161 TRNLRAHgddatDSHSIFSYEETAKLAVGRLSEYNHHFIKAFTYGSSVYFLFYRRDLKSQSREYKTYISRICLDDSHYYS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  261 YVELPLACEG--GRYGLIQAAAVATSRE-------VAHGEVLFAAFSSAAPPTVGRppsaaagaSGASALCAFPLDEVDR 331
Cdd:cd11275   241 YVELPLLCQSkaNTYSLLQAAYVTQPGErlaqgqlDTDGEVLFAAFSAWQASSGKL--------SEESALCAYPMDEVDR 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  332 LANRTRDACYTREGRAEDGTEVAYIEYDVNSDCAQLPVDTLDAYPCGSDHTPSPMASRVPLEATPILEWPGIQLTAVAVT 411
Cdd:cd11275   313 LTNWTRDVCYTRDGKAEDGTEVAYIEYDVSSNCVQLPADTLDAYPCGSDHTPSPMASRVPLEATPLLEWTEIRLTAVAVN 392

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194272180  412 MEDGHTIAFLGDSQGQLHRVYLGPGSDGHPYSTQSIQQGSAVSRDLTFDGTFEHLYVMTQSTLLKVPVA 480
Cdd:cd11275   393 VEDGHTIAFLGDSRGRLHKVYLGAGGDAHTYSSQSIQQNSAVSGDLLFDQLQEHLYVMTQSTVLKVPIA 461
TIG_2 pfam18020
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ...
 921-1020 7.31e-34

TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.


:

Pssm-ID: 465619  Cd Length: 94  Bit Score: 126.24  E-value: 7.31e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   921 GSTLMPVHVEREIRLLGRNLHLFQDGPGDNECVMELEGLEVVVEARVECEPppdtqcHVTCQQHQLSYEALQPELRVGLF 1000
Cdd:pfam18020    1 GSILVPVGVEREITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSD------SITCQEHQFSYSGSSGELPATFY 74

                           90       100
                   ....*....|....*....|
gi 194272180  1001 LRRAGRLRVDSAEGLHVVLY 1020
Cdd:pfam18020   75 VTWNGGHRLDNPANLQVVLY 94
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1070-1161 2.57e-33

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238585  Cd Length: 94  Bit Score: 124.35  E-value: 2.57e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1070 PLIHSVEPLTGPVDGGTRVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCITGASGEEVaGATAVEVPGRG 1149
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNPV-FNGPVEVTVGH 79

                          90
                  ....*....|....*
gi 194272180 1150 ---RGVSEHDFAYQD 1161
Cdd:cd01180    80 gsfRTESSEGFSFVD 94
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1252-1376 4.40e-32

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238586  Cd Length: 99  Bit Score: 121.37  E-value: 4.40e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1252 PNITSAGPTKSFLSGGREICVRGQNLDVVQTPRIRVTVVSRmlqpsqglgrrrrvvpetacslgpscssqqFEEPCHVNS 1331
Cdd:cd01181     1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKYGGV------------------------------EKTSCKVRN 50

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 194272180 1332 SQLITCRTPALPGLP---EDPWVRVEFILDNLVF-DFATLNPTPFSYEA 1376
Cdd:cd01181    51 STLMTCPAPSLALLNrspEPGERPVEFGLDGDNVqSLLILNRTSFSYYP 99
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1162-1249 4.36e-27

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238584  Cd Length: 85  Bit Score: 106.54  E-value: 4.36e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1162 PKVHSIFPARGPRAGGTRLTLNGSKLLTGRleDIRVVVGDQPCHLLPeQQSEQLRCETSPRPTPATLPVAVWFGATeRRL 1241
Cdd:cd01179     1 PSITSLSPSYGPQSGGTRLTITGKHLNAGS--SVRVTVGGQPCKILS-VSSSQIVCLTPPSASPGEAPVKVLIDGA-RRL 76


                  ....*...
gi 194272180 1242 QRGQFKYT 1249
Cdd:cd01179    77 APLVFTYT 84
TIG_plexin pfam17960
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ...
 541-627 1.43e-26

TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.


:

Pssm-ID: 465588  Cd Length: 89  Bit Score: 105.04  E-value: 1.43e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   541 PANISREETREVFLSVPDLPPLwpGESYSCHFGEH-QSPALLTGSGVMCPSPDPSEAPVLPRGADYVSVSVELRFGA--V 617
Cdd:pfam17960    2 PDNISRTTATQLTLTVPNLPAL--SEGYSCVFGDLtESPATVHDNGVKCATPPPSQLPPIPTGQDHVTVKLSLRSSEtgV 79

                           90
                   ....*....|
gi 194272180   618 VIAKTSLSFY 627
Cdd:pfam17960   80 DFASTNFTFY 89
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 481-527 1.12e-14

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


:

Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 70.04  E-value: 1.12e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 194272180   481 SCAQHLDCASCLAHRDPYCGWCVLLGRCSRRSECSrGQGPEQWLWSF 527
Cdd:pfam01437    1 RCSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACG-APEGNCEEWEQ 46
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 681-839 3.96e-08

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.18  E-value: 3.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  681 SPDPPARGGPsPSPPTAPKALATPAPDTLPVEPGAPSTATASDISPGASPSLLSPwgpwagsgsiSSPGSTGSPLHEEPS 760
Cdd:PHA03247 2732 SPALPAAPAP-PAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTR----------PAVASLSESRESLPS 2800

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  761 PPSPQNGPGTAVPAPTDFRPSATPEDLLASPLSPSEVAAVPPADPGPEALHP------------TVPLDLPPATVPATTF 828
Cdd:PHA03247 2801 PWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLggsvapggdvrrRPPSRSPAAKPAAPAR 2880

                         170
                  ....*....|.
gi 194272180  829 PGAMGSVKPAL 839
Cdd:PHA03247 2881 PPVRRLARPAV 2891
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
641-677 4.48e-06

domain found in Plexins, Semaphorins and Integrins;


:

Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 45.61  E-value: 4.48e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 194272180    641 CQACVSSRWG-CNWCVWQHLCTHKASCDAGPMVASHQS 677
Cdd:smart00423    8 CSECLLARDPyCAWCSSQGRCTSGERCDSRRQNWLSGG 45
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 1021-1061 2.85e-05

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


:

Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 43.47  E-value: 2.85e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 194272180  1021 DCSvGHGDCSRCQTAmPQYGCVWCEGERpRCVTREACGEAE 1061
Cdd:pfam01437    1 RCS-QYTSCSSCLAA-RDPYCGWCSSEG-RCVRRSACGAPE 38
 
Name Accession Description Interval E-value
Plexin_cytopl pfam08337
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
 1562-2097 0e+00

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 881.15  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  1562 GIPFLDYKVYAERIFFPGHRESPLHRDLGVP---ESRRPTVEQGLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVA 1638
Cdd:pfam08337    1 GIPFLDYRTYAMRVLFPGVEDHPLLVLLDVPvtnDGRRTNVEQALTQFSQLLNNKLFLLTFIRTLESQRSFSIRDRCNVA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  1639 SLLTVALHGKLEYFTDILRTLLSDLVAQYV-AKNPKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQ 1717
Cdd:pfam08337   81 SLLMVALHGKLEYATEILKTLLRDLIDKSVeSKNPKLLLRRTESVVEKMLTNWMSICLYPFLRECAGEPLFLLYKAIKQQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  1718 VDKGPVDSVTGKAKYTLNDNRLLREDVEYRPLTLNALLAVGpgaGEAQGVPVKVLDCDTISQAKEKMLDQLYKGVPLTQR 1797
Cdd:pfam08337  161 VEKGPVDAITGKARYTLSEDKLLREQIDYKTLTLHVIFEEG---ENSESVPVKVLDCDTITQVKEKILDAIYKNTPYSQR 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  1798 PDPRTLDVEWRSGVAGHLILSDEDVTSEVQGLWRRLNTLQHYKVPDGATVALVPcltkhvlrenqdyvpgertpmledvd 1877
Cdd:pfam08337  238 PSIDEVDLEWRHGRGGRLTLQDEDSTSKVEGGWKKLNTLAHYKVPDGATLALIP-------------------------- 291

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  1878 eggiRPWHLVKPSDEPEPprprrgslRGGERERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILST-SRPVPLAVKYFFD 1956
Cdd:pfam08337  292 ----KYWHLVKPSDEGDQ--------RKKSERRKKAIPEIYLTRLLSTKGTLQKFVDDLFESILSVpNSALPLAVKYLFD 359

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  1957 LLDEQAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINKL 2036
Cdd:pfam08337  360 FLDEQAEKHGITDPEVLHIWKSNSLPLRFWVNIIKNPQFVFDINKSPIVDSCLSVIAQTFMDSCSTSEHRLGKDSPSNKL 439

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 194272180  2037 LYARDIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINK 2097
Cdd:pfam08337  440 LYAKDIPRYKQMVERYYKDISNMPPISDQEMNAFLAEESRKHQNEFNTSAALKELYKYVNK 500
Sema_plexin_B1 cd11275
The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the ...
 28-480 0e+00

The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D-plexin B signaling complex regulates dendritic and axonal complexity. The activation of Plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200536 [Multi-domain]  Cd Length: 461  Bit Score: 855.80  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   28 FTPNGTYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDECPQAQPTNNPNQLLLVSPG- 106
Cdd:cd11275     1 FSPNGTKFLHLSMDPESGTLYLGATNFLFQLTPDLLLENMVQTGPVLDSKDCLPPVSKLECPQAQHTNNHNKLLLVNPVq 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  107 -ALVVCGSVHQGVCEQRRLGQLEQLLLRPERPGDTQYVAANDPAVSTVGLVAQGLAGEPLLFVGRGYTSRGVGGGIPPIT 185
Cdd:cd11275    81 kELIVCGSVHQGICEKRRLGSIDHVLFRPERPGDTQYVAANDPNVTTVGLVAYSKDGVPLLFVGRGYTSRGVGGGIPPIT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  186 TRALWPP-----DPQAAFSYEETAKLAVGRLSEYSHHFVSAFARGASAYFLFLRRDLQAQSRAFRAYVSRVCLRDQHYYS 260
Cdd:cd11275   161 TRNLRAHgddatDSHSIFSYEETAKLAVGRLSEYNHHFIKAFTYGSSVYFLFYRRDLKSQSREYKTYISRICLDDSHYYS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  261 YVELPLACEG--GRYGLIQAAAVATSRE-------VAHGEVLFAAFSSAAPPTVGRppsaaagaSGASALCAFPLDEVDR 331
Cdd:cd11275   241 YVELPLLCQSkaNTYSLLQAAYVTQPGErlaqgqlDTDGEVLFAAFSAWQASSGKL--------SEESALCAYPMDEVDR 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  332 LANRTRDACYTREGRAEDGTEVAYIEYDVNSDCAQLPVDTLDAYPCGSDHTPSPMASRVPLEATPILEWPGIQLTAVAVT 411
Cdd:cd11275   313 LTNWTRDVCYTRDGKAEDGTEVAYIEYDVSSNCVQLPADTLDAYPCGSDHTPSPMASRVPLEATPLLEWTEIRLTAVAVN 392

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194272180  412 MEDGHTIAFLGDSQGQLHRVYLGPGSDGHPYSTQSIQQGSAVSRDLTFDGTFEHLYVMTQSTLLKVPVA 480
Cdd:cd11275   393 VEDGHTIAFLGDSRGRLHKVYLGAGGDAHTYSSQSIQQNSAVSGDLLFDQLQEHLYVMTQSTVLKVPIA 461
RasGAP_plexin_B1 cd12793
Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane ...
 1562-2134 0e+00

Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D and plexin-B1 signaling complex regulates dendritic and axonal complexity. The activation of Plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin-B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin-B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin-B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213353 [Multi-domain]  Cd Length: 394  Bit Score: 788.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1562 GIPFLDYKVYAERIFFPGHRESPLHRDLGVPESRRPTVEQGLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVASLL 1641
Cdd:cd12793     1 GIPFLDYRMYAERIFFPGHRESPLRRDLDVPECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLESQRTFSPRDRAYVASLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1642 TVALHGKLEYFTDILRTLLSDLVAQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVDKG 1721
Cdd:cd12793    81 TVALHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFLRDSAGESLYMLFRAIKHQVDKG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1722 PVDSVTGKakytlndnrllredveyrpltlnallavgpgageaqgvpvkvldcdtisqakekmldqlykgvpltqrpdpr 1801
Cdd:cd12793   161 PVDAVTGK------------------------------------------------------------------------ 168

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1802 tldvewrsgvaghlilsdedvtsevqglwrrlntlqhykvpdgatvalvpcltkhvlrenqdyvpgertpmledvdeggi 1881
Cdd:cd12793       --------------------------------------------------------------------------------

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1882 rpwhlvkpsdepepprprrgslrggerERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLLDEQ 1961
Cdd:cd12793   169 ---------------------------ERAKAIPEIYLTRLLSMKGTLQKFVDDLFTVILSTSRPVPLAVKYFFDLLDEQ 221

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1962 AQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINKLLYARD 2041
Cdd:cd12793   222 ALQHGISDPETIHIWKTNSLPLRFWINIIKNPQFIFDVQTSDNVDAVLSVIAQTFMDSCTIADHKLGRDSPINKLLYARD 301

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 2042 IPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINKYYDQIITALEEDGTAQKMQLGYRL 2121
Cdd:cd12793   302 IPRYKQMVERYYADIRQTVSASDQEMNSALAELSRNYSGELNYLVALHELYKYINKYYDQIITALEEDSTAQKMQLGYRL 381

                         570
                  ....*....|...
gi 194272180 2122 QQIAAAVENKVTD 2134
Cdd:cd12793   382 QQIAAAVENKVTD 394
Sema smart00630
semaphorin domain;
35-454 7.83e-82

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 275.40  E-value: 7.83e-82
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180     35 LQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPdecPQAQPTNNPNQLLLV---SPGALVVC 111
Cdd:smart00630    1 LQHLLLDEDNGTLYVGARNRLYQLSLNLILEAELKTGPVLSSPDCEECVSK---GKDPPTDCVNYIRLLldyNEDRLLVC 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180    112 GS-VHQGVCEQRRLGQLeqlllrperpgdtqyvaandpavstvglvaqglagepllFVGRGYTSRGVGGGIPPITTralW 190
Cdd:smart00630   78 GTnAFQPVCRLRNLGEL---------------------------------------YVGTVADFSGSDPAIPRSLS---V 115

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180    191 PPDPQAAFSYEETAKLAVGRLseYSHHFVSAFARGASAYFLFLRR--DLQAQSRAFRAYVSRVCLRD--------QHYYS 260
Cdd:smart00630  116 RRLKGTSGVSLRTVLYDSKWL--NEPNFVYAFESGDFVYFFFRETavEDDNCGKAVHSRVARVCKNDvggprsldKKWTS 193

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180    261 YVELPLACEGG-----RYGLIQAAAVATSREVaHGEVLFAAFSSAAPPTVGrppsaaagasgaSALCAFPLDEVDRLANR 335
Cdd:smart00630  194 FLKARLECSVPgedpfYFNELQAAFLLPPGSE-SDDVLYGVFSTSSNPIPG------------SAVCAFSLSDINAVFNG 260

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180    336 TRDACYTREGRAEDGTEvAYIEYDVNSDCAQLPVDTLDaYPC----GSDHTPSPMASRVPLEATPIL--EWPGIQLTAVA 409
Cdd:smart00630  261 PFKECETSTSQWLPYSR-GKVPYPRPGTCPNKPPSSKD-LPDetlnFIKSHPLMDEVVQPLTGRPLFvkTDSNYLLTSIA 338

                           410       420       430       440       450
                    ....*....|....*....|....*....|....*....|....*....|..
gi 194272180    410 VTMED---GHTIAFLGDSQGQLHRVYLGPGSDGHP---YSTQSIQQ-GSAVS 454
Cdd:smart00630  339 VDRVAtdgNYTVLFLGTSDGRILKVVLSESSSSSEsvvLEEISVFPdGSPIS 390
TIG_2 pfam18020
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ...
 921-1020 7.31e-34

TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.


Pssm-ID: 465619  Cd Length: 94  Bit Score: 126.24  E-value: 7.31e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   921 GSTLMPVHVEREIRLLGRNLHLFQDGPGDNECVMELEGLEVVVEARVECEPppdtqcHVTCQQHQLSYEALQPELRVGLF 1000
Cdd:pfam18020    1 GSILVPVGVEREITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSD------SITCQEHQFSYSGSSGELPATFY 74

                           90       100
                   ....*....|....*....|
gi 194272180  1001 LRRAGRLRVDSAEGLHVVLY 1020
Cdd:pfam18020   75 VTWNGGHRLDNPANLQVVLY 94
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1070-1161 2.57e-33

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 124.35  E-value: 2.57e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1070 PLIHSVEPLTGPVDGGTRVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCITGASGEEVaGATAVEVPGRG 1149
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNPV-FNGPVEVTVGH 79

                          90
                  ....*....|....*
gi 194272180 1150 ---RGVSEHDFAYQD 1161
Cdd:cd01180    80 gsfRTESSEGFSFVD 94
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1252-1376 4.40e-32

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238586  Cd Length: 99  Bit Score: 121.37  E-value: 4.40e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1252 PNITSAGPTKSFLSGGREICVRGQNLDVVQTPRIRVTVVSRmlqpsqglgrrrrvvpetacslgpscssqqFEEPCHVNS 1331
Cdd:cd01181     1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKYGGV------------------------------EKTSCKVRN 50

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 194272180 1332 SQLITCRTPALPGLP---EDPWVRVEFILDNLVF-DFATLNPTPFSYEA 1376
Cdd:cd01181    51 STLMTCPAPSLALLNrspEPGERPVEFGLDGDNVqSLLILNRTSFSYYP 99
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1162-1249 4.36e-27

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 106.54  E-value: 4.36e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1162 PKVHSIFPARGPRAGGTRLTLNGSKLLTGRleDIRVVVGDQPCHLLPeQQSEQLRCETSPRPTPATLPVAVWFGATeRRL 1241
Cdd:cd01179     1 PSITSLSPSYGPQSGGTRLTITGKHLNAGS--SVRVTVGGQPCKILS-VSSSQIVCLTPPSASPGEAPVKVLIDGA-RRL 76


                  ....*...
gi 194272180 1242 QRGQFKYT 1249
Cdd:cd01179    77 APLVFTYT 84
TIG_plexin pfam17960
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ...
 541-627 1.43e-26

TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.


Pssm-ID: 465588  Cd Length: 89  Bit Score: 105.04  E-value: 1.43e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   541 PANISREETREVFLSVPDLPPLwpGESYSCHFGEH-QSPALLTGSGVMCPSPDPSEAPVLPRGADYVSVSVELRFGA--V 617
Cdd:pfam17960    2 PDNISRTTATQLTLTVPNLPAL--SEGYSCVFGDLtESPATVHDNGVKCATPPPSQLPPIPTGQDHVTVKLSLRSSEtgV 79

                           90
                   ....*....|
gi 194272180   618 VIAKTSLSFY 627
Cdd:pfam17960   80 DFASTNFTFY 89
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
 276-460 2.18e-17

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 81.93  E-value: 2.18e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   276 IQAAAVAT-SREVAHGEVLFAAFSSAAPPTVGRppsaaagasgaSALCAFPLDEVDRLANRtRDACYTREGRAEDGTEVA 354
Cdd:pfam01403    1 LQDVFVLKpGAGDALDTVLYGVFTTQWSNSIGG-----------SAVCAFSLSDINAVFEG-PFKEQEKSDSKWLPYTGK 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   355 yIEYDVNSDCAQLPV--DTLDAYPCGSDHTPSPMASRVPLEATPILEWPGIQLTAVAVTM---EDG-HTIAFLGDSQGQL 428
Cdd:pfam01403   69 -VPYPRPGTCINDPLrlDLPDSVLNFVKDHPLMDEAVQPVGGRPLLVRTGVRLTSIAVDRvqaLDGnYTVLFLGTDDGRL 147

                          170       180       190
                   ....*....|....*....|....*....|...
gi 194272180   429 HRVYLGPGSDGHPYSTQSI-QQGSAVSRDLTFD 460
Cdd:pfam01403  148 HKVVLVGSEESHIIEEIQVfPEPQPVLNLLLSS 180
IPT smart00429
ig-like, plexins, transcription factors;
1161-1249 3.31e-16

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 75.53  E-value: 3.31e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   1161 DPKVHSIFPARGPRAGGTRLTLNGSKLLTGRLEDIRVVVGDQPCHLLPEQQSeQLRCETSPRPT-PATLPV-AVWFGATE 1238
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAPCTFSPSSST-AIVCKTPPYHNiPGSVPVrTVGLRNGG 79

                            90
                    ....*....|.
gi 194272180   1239 RRLQRGQFKYT 1249
Cdd:smart00429   80 VPSSPQPFTYV 90
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 481-527 1.12e-14

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 70.04  E-value: 1.12e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 194272180   481 SCAQHLDCASCLAHRDPYCGWCVLLGRCSRRSECSrGQGPEQWLWSF 527
Cdd:pfam01437    1 RCSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACG-APEGNCEEWEQ 46
IPT smart00429
ig-like, plexins, transcription factors;
1070-1159 7.44e-14

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 68.99  E-value: 7.44e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   1070 PLIHSVEPLTGPVDGGTRVTIRGSNLGQhVQDVLGMVTVAGVPCAVDAQEyevSSSLVCITGASGEEVAGATAVEVPGRG 1149
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKS-ISVVFVEVGVGEAPCTFSPSS---STAIVCKTPPYHNIPGSVPVRTVGLRN 77

                            90
                    ....*....|..
gi 194272180   1150 RGV--SEHDFAY 1159
Cdd:smart00429   78 GGVpsSPQPFTY 89
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
482-520 3.55e-12

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 62.56  E-value: 3.55e-12
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 194272180    482 CAQHLDCASCLAHRDPYCGWCVLLGRCSRRSECSRGQGP 520
Cdd:smart00423    2 CSKYTSCSECLLARDPYCAWCSSQGRCTSGERCDSRRQN 40
IPT smart00429
ig-like, plexins, transcription factors;
1251-1374 1.19e-11

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 62.82  E-value: 1.19e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   1251 DPNITSAGPTKSFLSGGREICVRGQNLDVVQTPRIRVTVVsrmlqpsqglgrrrrvvpETACSLGPSCSSQqfeepchvn 1330
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVG------------------EAPCTFSPSSSTA--------- 53

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*
gi 194272180   1331 ssqlITCRTPALPGLPEDPWVR-VEFILDNLVFDfatlnPTPFSY 1374
Cdd:smart00429   54 ----IVCKTPPYHNIPGSVPVRtVGLRNGGVPSS-----PQPFTY 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1070-1159 7.70e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 60.15  E-value: 7.70e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  1070 PLIHSVEPLTGPVDGGTRVTIRGSNLGQHVQDVlgMVTVAGVPCAVDAQEyevSSSLVCITGASGEEVAGATaVEVPGRG 1149
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDL--KVTIGGTPCTVISVS---STTIVCTTPPGTSGLVNVS-VTVGGGG 74

                           90
                   ....*....|
gi 194272180  1150 RGVSEHDFAY 1159
Cdd:pfam01833   75 ISSSPLTFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1162-1248 1.42e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 59.38  E-value: 1.42e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  1162 PKVHSIFPARGPRAGGTRLTLNGSKLLTGRlEDIRVVVGDQPChLLPEQQSEQLRCETSPRpTPATLPVAVWFGATERRL 1241
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDS-SDLKVTIGGTPC-TVISVSSTTIVCTTPPG-TSGLVNVSVTVGGGGISS 77


                   ....*..
gi 194272180  1242 QRGQFKY 1248
Cdd:pfam01833   78 SPLTFTY 84
PHA03247 PHA03247
large tegument protein UL36; Provisional
 681-839 3.96e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.18  E-value: 3.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  681 SPDPPARGGPsPSPPTAPKALATPAPDTLPVEPGAPSTATASDISPGASPSLLSPwgpwagsgsiSSPGSTGSPLHEEPS 760
Cdd:PHA03247 2732 SPALPAAPAP-PAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTR----------PAVASLSESRESLPS 2800

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  761 PPSPQNGPGTAVPAPTDFRPSATPEDLLASPLSPSEVAAVPPADPGPEALHP------------TVPLDLPPATVPATTF 828
Cdd:PHA03247 2801 PWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLggsvapggdvrrRPPSRSPAAKPAAPAR 2880

                         170
                  ....*....|.
gi 194272180  829 PGAMGSVKPAL 839
Cdd:PHA03247 2881 PPVRRLARPAV 2891
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 670-837 4.66e-07

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 55.16  E-value: 4.66e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   670 PMVASHQSPLVSPDPPARGGPSPSPPTAPkalaTPAPDTLPVEPGAPSTATASDISPGASPSLLSPWGPWAGSGSISSPG 749
Cdd:pfam03154  171 PPVLQAQSGAASPPSPPPPGTTQAATAGP----TPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPH 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   750 STGSPLHEEPSPP--SPQ-------NGPGTAVPAPTDFRPSATPEDLLAS-------------PLSPSEVAAV------- 800
Cdd:pfam03154  247 PPLQPMTQPPPPSqvSPQplpqpslHGQMPPMPHSLQTGPSHMQHPVPPQpfpltpqssqsqvPPGPSPAAPGqsqqrih 326

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 194272180   801 -PPADPGPEALHPTVPLDLPPAtvpattfPGAMGSVKP 837
Cdd:pfam03154  327 tPPSQSQLQSQQPPREQPLPPA-------PLSMPHIKP 357
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
641-677 4.48e-06

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 45.61  E-value: 4.48e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 194272180    641 CQACVSSRWG-CNWCVWQHLCTHKASCDAGPMVASHQS 677
Cdd:smart00423    8 CSECLLARDPyCAWCSSQGRCTSGERCDSRRQNWLSGG 45
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 1021-1061 2.85e-05

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 43.47  E-value: 2.85e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 194272180  1021 DCSvGHGDCSRCQTAmPQYGCVWCEGERpRCVTREACGEAE 1061
Cdd:pfam01437    1 RCS-QYTSCSSCLAA-RDPYCGWCSSEG-RCVRRSACGAPE 38
KLF9_13_N-like cd21975
Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like ...
 680-826 5.65e-05

Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF9, KLF13, KLF14, KLF16, and similar proteins.


Pssm-ID: 409240 [Multi-domain]  Cd Length: 163  Bit Score: 45.84  E-value: 5.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  680 VSPDPPARGGPSPSPPTAPKA-LATPAPDTLPVEPGAPSTATASdispGASPSLL--SPWGPWAGSGSISSPGSTGSPLH 756
Cdd:cd21975    21 VRPDPEGAGLAAGLDVRATREvAKGPGPPGPAWKPDGADSPGLV----TAAPHLLaaNVLAPLRGPSVEGSSLESGDADM 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  757 EEPSPPSPQngPGTAvpaptdfrPSATPEDLLASPLSPSEVAAVPPADPGPEALHPTVPLDLPPATVPAT 826
Cdd:cd21975    97 GSDSDVAPA--SGAA--------ASTSPESSSDAASSPSPLSLLHPGEAGLEPERPRPRVRRGVRRRGVT 156
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
1021-1068 6.61e-05

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 42.15  E-value: 6.61e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 194272180   1021 DCSVgHGDCSRCQTAMPQYgCVWCEGERpRCVTREACGE--AEAVATQCP 1068
Cdd:smart00423    1 RCSK-YTSCSECLLARDPY-CAWCSSQG-RCTSGERCDSrrQNWLSGGCP 47
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 641-666 3.64e-03

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 37.30  E-value: 3.64e-03
                           10        20
                   ....*....|....*....|....*..
gi 194272180   641 CQACVSSR-WGCNWCVWQHLCTHKASC 666
Cdd:pfam01437    8 CSSCLAARdPYCGWCSSEGRCVRRSAC 34
half-pint TIGR01645
poly-U binding splicing factor, half-pint family; The proteins represented by this model ...
 696-880 5.23e-03

poly-U binding splicing factor, half-pint family; The proteins represented by this model contain three RNA recognition motifs (rrm: pfam00076) and have been characterized as poly-pyrimidine tract binding proteins associated with RNA splicing factors. In the case of PUF60 (GP|6176532), in complex with p54, and in the presence of U2AF, facilitates association of U2 snRNP with pre-mRNA.


Pssm-ID: 130706 [Multi-domain]  Cd Length: 612  Bit Score: 41.98  E-value: 5.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   696 TAPKALATPA-PDTLPVEPG---APSTA--TASDISPGAS---PSLLSPWGPWAGSGSISSPGSTGSPLHEEPS--PPSP 764
Cdd:TIGR01645  283 TPPDALLQPAtVSAIPAAAAvaaAAATAkiMAAEAVAGAAvlgPRAQSPATPSSSLPTDIGNKAVVSSAKKEAEevPPLP 362

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   765 QNGPGTAVPAPTDFrPSATPEDLLASPLSPSEVAAVPPADPGPEAL-HPTVPLDLppatvpaTTFPGAMGSVKPALDWLT 843
Cdd:TIGR01645  363 QAAPAVVKPGPMEI-PTPVPPPGLAIPSLVAPPGLVAPTEINPSFLaSPRKKMKR-------EKLPVTFGALDDTLAWKE 434

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 194272180   844 REGGELPEADEWTGGDAPAFSTSTLLSGDGDSAELEG 880
Cdd:TIGR01645  435 PSKEDQTSEDGKMLAIMGEAAAALALEPKKKKKEKEG 471
 
Name Accession Description Interval E-value
Plexin_cytopl pfam08337
Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various ...
 1562-2097 0e+00

Plexin cytoplasmic RasGAP domain; This family features the C-terminal regions of various plexins. Plexins are receptors for semaphorins, and plexin signalling is important in path finding and patterning of both neurons and developing blood vessels. The cytoplasmic region, which has been called a SEX domain in some members of this family, is involved in downstream signalling pathways, by interaction with proteins such as Rac1, RhoD, Rnd1 and other plexins. This domain acts as a RasGAP domain.


Pssm-ID: 462434 [Multi-domain]  Cd Length: 500  Bit Score: 881.15  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  1562 GIPFLDYKVYAERIFFPGHRESPLHRDLGVP---ESRRPTVEQGLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVA 1638
Cdd:pfam08337    1 GIPFLDYRTYAMRVLFPGVEDHPLLVLLDVPvtnDGRRTNVEQALTQFSQLLNNKLFLLTFIRTLESQRSFSIRDRCNVA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  1639 SLLTVALHGKLEYFTDILRTLLSDLVAQYV-AKNPKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQ 1717
Cdd:pfam08337   81 SLLMVALHGKLEYATEILKTLLRDLIDKSVeSKNPKLLLRRTESVVEKMLTNWMSICLYPFLRECAGEPLFLLYKAIKQQ 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  1718 VDKGPVDSVTGKAKYTLNDNRLLREDVEYRPLTLNALLAVGpgaGEAQGVPVKVLDCDTISQAKEKMLDQLYKGVPLTQR 1797
Cdd:pfam08337  161 VEKGPVDAITGKARYTLSEDKLLREQIDYKTLTLHVIFEEG---ENSESVPVKVLDCDTITQVKEKILDAIYKNTPYSQR 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  1798 PDPRTLDVEWRSGVAGHLILSDEDVTSEVQGLWRRLNTLQHYKVPDGATVALVPcltkhvlrenqdyvpgertpmledvd 1877
Cdd:pfam08337  238 PSIDEVDLEWRHGRGGRLTLQDEDSTSKVEGGWKKLNTLAHYKVPDGATLALIP-------------------------- 291

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  1878 eggiRPWHLVKPSDEPEPprprrgslRGGERERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILST-SRPVPLAVKYFFD 1956
Cdd:pfam08337  292 ----KYWHLVKPSDEGDQ--------RKKSERRKKAIPEIYLTRLLSTKGTLQKFVDDLFESILSVpNSALPLAVKYLFD 359

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  1957 LLDEQAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINKL 2036
Cdd:pfam08337  360 FLDEQAEKHGITDPEVLHIWKSNSLPLRFWVNIIKNPQFVFDINKSPIVDSCLSVIAQTFMDSCSTSEHRLGKDSPSNKL 439

                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 194272180  2037 LYARDIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINK 2097
Cdd:pfam08337  440 LYAKDIPRYKQMVERYYKDISNMPPISDQEMNAFLAEESRKHQNEFNTSAALKELYKYVNK 500
Sema_plexin_B1 cd11275
The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the ...
 28-480 0e+00

The Sema domain, a protein interacting module, of Plexin B1; Plexin B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D-plexin B signaling complex regulates dendritic and axonal complexity. The activation of Plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200536 [Multi-domain]  Cd Length: 461  Bit Score: 855.80  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   28 FTPNGTYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDECPQAQPTNNPNQLLLVSPG- 106
Cdd:cd11275     1 FSPNGTKFLHLSMDPESGTLYLGATNFLFQLTPDLLLENMVQTGPVLDSKDCLPPVSKLECPQAQHTNNHNKLLLVNPVq 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  107 -ALVVCGSVHQGVCEQRRLGQLEQLLLRPERPGDTQYVAANDPAVSTVGLVAQGLAGEPLLFVGRGYTSRGVGGGIPPIT 185
Cdd:cd11275    81 kELIVCGSVHQGICEKRRLGSIDHVLFRPERPGDTQYVAANDPNVTTVGLVAYSKDGVPLLFVGRGYTSRGVGGGIPPIT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  186 TRALWPP-----DPQAAFSYEETAKLAVGRLSEYSHHFVSAFARGASAYFLFLRRDLQAQSRAFRAYVSRVCLRDQHYYS 260
Cdd:cd11275   161 TRNLRAHgddatDSHSIFSYEETAKLAVGRLSEYNHHFIKAFTYGSSVYFLFYRRDLKSQSREYKTYISRICLDDSHYYS 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  261 YVELPLACEG--GRYGLIQAAAVATSRE-------VAHGEVLFAAFSSAAPPTVGRppsaaagaSGASALCAFPLDEVDR 331
Cdd:cd11275   241 YVELPLLCQSkaNTYSLLQAAYVTQPGErlaqgqlDTDGEVLFAAFSAWQASSGKL--------SEESALCAYPMDEVDR 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  332 LANRTRDACYTREGRAEDGTEVAYIEYDVNSDCAQLPVDTLDAYPCGSDHTPSPMASRVPLEATPILEWPGIQLTAVAVT 411
Cdd:cd11275   313 LTNWTRDVCYTRDGKAEDGTEVAYIEYDVSSNCVQLPADTLDAYPCGSDHTPSPMASRVPLEATPLLEWTEIRLTAVAVN 392

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194272180  412 MEDGHTIAFLGDSQGQLHRVYLGPGSDGHPYSTQSIQQGSAVSRDLTFDGTFEHLYVMTQSTLLKVPVA 480
Cdd:cd11275   393 VEDGHTIAFLGDSRGRLHKVYLGAGGDAHTYSSQSIQQNSAVSGDLLFDQLQEHLYVMTQSTVLKVPIA 461
RasGAP_plexin_B1 cd12793
Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane ...
 1562-2134 0e+00

Ras-GTPase Activating Domain of plexin-B1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B1 serves as the Semaphorin 4D receptor and functions as a regulator of developing neurons and a tumor suppressor protein for melanoma. The Sema4D and plexin-B1 signaling complex regulates dendritic and axonal complexity. The activation of Plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. As a tumor suppressor, plexin-B1 abrogates activation of the oncogenic receptor, c-Met, by its ligand, hepatocyte growth factor (HGF), in melanoma. Furthermore, plexin-B1 suppresses integrin-dependent migration and activation of pp125FAK and inhibits Rho activity. Plexin-B1 is highly expressed in endothelial cells and its activation by Sema4D elicits a potent proangiogenic response. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213353 [Multi-domain]  Cd Length: 394  Bit Score: 788.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1562 GIPFLDYKVYAERIFFPGHRESPLHRDLGVPESRRPTVEQGLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVASLL 1641
Cdd:cd12793     1 GIPFLDYRMYAERIFFPGHRESPLRRDLDVPECRRQTVEQGLVQLSNLLNSKLFLTKFIHTLESQRTFSPRDRAYVASLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1642 TVALHGKLEYFTDILRTLLSDLVAQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVDKG 1721
Cdd:cd12793    81 TVALHGKLEYFTDILKTLLNDLVEQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFLRDSAGESLYMLFRAIKHQVDKG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1722 PVDSVTGKakytlndnrllredveyrpltlnallavgpgageaqgvpvkvldcdtisqakekmldqlykgvpltqrpdpr 1801
Cdd:cd12793   161 PVDAVTGK------------------------------------------------------------------------ 168

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1802 tldvewrsgvaghlilsdedvtsevqglwrrlntlqhykvpdgatvalvpcltkhvlrenqdyvpgertpmledvdeggi 1881
Cdd:cd12793       --------------------------------------------------------------------------------

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1882 rpwhlvkpsdepepprprrgslrggerERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLLDEQ 1961
Cdd:cd12793   169 ---------------------------ERAKAIPEIYLTRLLSMKGTLQKFVDDLFTVILSTSRPVPLAVKYFFDLLDEQ 221

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1962 AQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINKLLYARD 2041
Cdd:cd12793   222 ALQHGISDPETIHIWKTNSLPLRFWINIIKNPQFIFDVQTSDNVDAVLSVIAQTFMDSCTIADHKLGRDSPINKLLYARD 301

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 2042 IPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINKYYDQIITALEEDGTAQKMQLGYRL 2121
Cdd:cd12793   302 IPRYKQMVERYYADIRQTVSASDQEMNSALAELSRNYSGELNYLVALHELYKYINKYYDQIITALEEDSTAQKMQLGYRL 381

                         570
                  ....*....|...
gi 194272180 2122 QQIAAAVENKVTD 2134
Cdd:cd12793   382 QQIAAAVENKVTD 394
RasGAP_plexin_B cd12787
Ras-GTPase Activating Domain of type B plexins; Plexins form a conserved family of ...
 1562-2130 0e+00

Ras-GTPase Activating Domain of type B plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity.There are three members of the Plexin-B subfamily, namely B1, B2 and B3. Plexins-B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin-B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin-B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin-B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin-B signaling. Plexin-B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin-B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213347 [Multi-domain]  Cd Length: 391  Bit Score: 756.00  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1562 GIPFLDYKVYAERIFFPGHRESPLHRD--LGVPESRRPTVEQGLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVAS 1639
Cdd:cd12787     1 GIPFLDYKTYAERVFFPGHKDGPLDVMikLDIPEPRRPTVEQGLYQLSNLLNSKLFLINFIHTLENQREFSARDRVYVAS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1640 LLTVALHGKLEYFTDILRTLLSDLVAQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVD 1719
Cdd:cd12787    81 LLTVALHGKLEYYTDIMRTLLLDLLAQYVVKNPKLMLRRTETVVEKLLTNWMSICLYQFLRDSAGEPLYMLFRAIKHQVD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1720 KGPVDSVTGKakytlndnrllredveyrpltlnallavgpgageaqgvpvkvldcdtisqakekmldqlykgvpltqrpd 1799
Cdd:cd12787   161 KGPVDAVTGK---------------------------------------------------------------------- 170

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1800 prtldvewrsgvaghlilsdedvtsevqglwrrlntlqhykvpdgatvalvpcltkhvlrenqdyvpgertpmledvdeg 1879
Cdd:cd12787       --------------------------------------------------------------------------------

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1880 girpwhlvkpsdepepprprrgslrggereRAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLLD 1959
Cdd:cd12787   171 ------------------------------RAKAIPEIYLTRLLSMKGTLQKFVDDFFQSILSPGRPVPPAVKYFFDLLD 220

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1960 EQAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINKLLYA 2039
Cdd:cd12787   221 EQAEKHGIQDEDTIHIWKTNSLPLRFWVNILKNPQFIFDVHVSDNVDASLSVIAQTFMDACTRTEHKLGRDSPSNKLLYA 300

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 2040 RDIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINKYYDQIITALEEDGTAQKMQLGY 2119
Cdd:cd12787   301 REIPRYKKMVERYYADIRQMVPASDQEMNSHLAELSRNYTDSLNTLVALHELYQYIQKYYDQIINALEEDPAAQKMQLAF 380

                         570
                  ....*....|.
gi 194272180 2120 RLQQIAAAVEN 2130
Cdd:cd12787   381 RLQQIAAAVEN 391
Sema_plexin_B cd11245
The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin ...
 34-480 0e+00

The Sema domain, a protein interacting module, of Plexin B; Plexins, which contain semaphorin domains, function as receptors of semaphorins and may be the ancestors of semaphorins. There are three members of the Plexin B subfamily, namely B1, B2 and B3. Plexins B1, B2 and B3 are receptors for Sema4D, Sema4C and Sema4G, and Sema5A, respectively. The activation of plexin B1 by Sema4D produces an acute collapse of axonal growth cones in hippocampal and retinal neurons over the early stages of neurite outgrowth and promotes branching and complexity. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Plexin B3, the receptor of Sema5A, is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Small GTPases play important roles in plexin B signaling. Plexin B1 activates Rho through Rho-specific guanine nucleotide exchange factors, leading to neurite retraction. Plexin B1 possesses an intrinsic GTPase-activating protein activity for R-Ras and induces growth cone collapse through R-Ras inactivation. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200506 [Multi-domain]  Cd Length: 440  Bit Score: 752.92  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   34 YLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDECPQAQPTNNPNQLLLVSP--GALVVC 111
Cdd:cd11245     1 IINHLAQDPQTGRLYLGAVNGLFQLSPNLQLESRADTGPKKDSPQCLPPITAAECPQAKETDNFNKLLLVNSanGTLVVC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  112 GSVHQGVCEQRRLGQLEQLLLRPERPGDTQYVAANDPAVSTVGLVAQGLAGEPLLFVGRGYTSRGvGGGIPPITTRALWP 191
Cdd:cd11245    81 GSLFQGVCELRNLNSVNKPLYRPETPGDKQYVAANEPSVSTVGLISYFKDGLSLLFVGRGYTSSL-SGGIPPITTRLLQE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  192 PDPQAAFSYEETAKLAVGRLSEYSHHFVSAFARGASAYFLFLRRDLQAQsRAFRAYVSRVCLRDQHYYSYVELPLACE-- 269
Cdd:cd11245   160 HGEMDAFSNEVEAKLVVGSASRYHHDFVYAFADNGYIYFLFSRRPGTAD-STKRTYISRLCENDHHYYSYVELPLNCTvn 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  270 -GGRYGLIQAAAVATSREVAHGEVLFAAFSSAAPPTVGrppsaaagASGASALCAFPLDEVDRLANRTRDACYTREGRAE 348
Cdd:cd11245   239 qENTYNLVQAAYLAKPGKVLNGKVLFGVFSADEASTAA--------PDGRSALCMYPLSSVDARFERTRESCYTGEGLED 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  349 DGTEVAYIEYDVNSDCAQLPVDTLDAYPCGSDHTPSPMASRVPLEATPILEWPgIQLTAVAVTMEDGHTIAFLGDSQGQL 428
Cdd:cd11245   311 DKPETAYIEYNVKSICKTLPDKNVKAYPCGAEHTPSPLASRYPLAAKPILTRN-DMLTAVAVAVENGHTIAFLGDSGGQL 389

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 194272180  429 HRVYLGPGsDGHPYSTQSIQQGSAVSRDLTFDGTFEHLYVMTQSTLLKVPVA 480
Cdd:cd11245   390 HKVYLDPN-HTDFYSTIPGDQDSAVNKDLLFDSTLNHLYVMTGKKISKVPVQ 440
RasGAP_plexin_B3 cd12791
Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane ...
 1562-2134 0e+00

Ras-GTPase Activating Domain of plexin-B3; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin-B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin-B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The protein and mRNA expression of Sema5A and its receptor plexin-B3 increased gradually in non-neoplastic mucosa, primary gastric carcinoma, and lymph node metastasis, and their expression is correlated. The stimulation of plexin-B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213351 [Multi-domain]  Cd Length: 397  Bit Score: 682.34  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1562 GIPFLDYKVYAERIFFPGHRESPLHR--DLGVPESRRPTVEQGLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVAS 1639
Cdd:cd12791     1 GIPFLDYRTYAERVFFPGHGGCPLQPslEGDGEEGRRATVEQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVAS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1640 LLTVALHGKLEYFTDILRTLLSDLVAQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVD 1719
Cdd:cd12791    81 LLSLALHGKLEYLTDIMKTLLGDLAAHYVHKNPKLMLRRTETMVEKLLTNWMSICLYAFLREVAGEPLYMLFRAIKYQVD 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1720 KGPVDSVTGKakytlndnrllredveyrpltlnallavgpgageaqgvpvkvldcdtisqakekmldqlykgvpltqrpd 1799
Cdd:cd12791   161 KGPVDAVTGK---------------------------------------------------------------------- 170

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1800 prtldvewrsgvaghlilsdedvtsevqglwrrlntlqhykvpdgatvalvpcltkhvlrenqdyvpgertpmledvdeg 1879
Cdd:cd12791       --------------------------------------------------------------------------------

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1880 girpwhlvkpsdepepprprrgslrggeRERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLLD 1959
Cdd:cd12791   171 ----------------------------RERAKAIPEIYLTRLLSMKGTLQKFVDDTFQAILSVNRPVPIAVKYLFDFLD 222

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1960 EQAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINKLLYA 2039
Cdd:cd12791   223 ELAEKHGIEDPETLHIWKTNSLLLRFWVNTLKNPQFIFDVRVSDNVDAILAVIAQTFIDSCTISEHKVGRDSPVNKLLYA 302

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 2040 RDIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINKYYDQIITALEEDGTAQKMQLGY 2119
Cdd:cd12791   303 REIPRYKQMVEKYYADIRQSSPASYQEMNSALTELSGNYTSAPHCLVALQELYNHIHRYYDQIISALEEDPVGQKMQLAC 382

                         570
                  ....*....|....*
gi 194272180 2120 RLQQIAAAVENKVTD 2134
Cdd:cd12791   383 RLQQIAALVENKVTD 397
RasGAP_plexin cd12205
Ras-GTPase Activating Domain of plexins; Plexins form a conserved family of transmembrane ...
 1562-2126 0e+00

Ras-GTPase Activating Domain of plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes, including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Other proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213344 [Multi-domain]  Cd Length: 382  Bit Score: 578.02  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1562 GIPFLDYKVYAERIFFPGHRESPLHRDLGVPESRRPTVEQGLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVASLL 1641
Cdd:cd12205     1 GIPFLDFREYIIRVLFPGVNDHPVLLSKFVHGSRRPDLEDALSQFEQLLCNKQFLLTFIRTLESQPKFSSRDKCNVASLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1642 TVALHGKLEYFTDILRTLLSDLVAQYVAK-NPKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVDK 1720
Cdd:cd12205    81 MVALQGKMEYATEILFDLLTDLIEKSVSKkHPKLMLRRTESVVEKLLTNWLSLCLYDYLKETAGEPLFLLYKALKQQIEK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1721 GPVDSVtgkakytlndnrllredveyrpltlnallavgpgageaqgvpvkvldcdtisqakekmldqlykgvpltqrpdp 1800
Cdd:cd12205   161 GPVDAI-------------------------------------------------------------------------- 166

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1801 rtldvewrsgvaghlilsdedvtsevqglwrrlntlqhykvpdgatvalvpcltkhvlrenqdyvpgertpmledvdegg 1880
Cdd:cd12205       --------------------------------------------------------------------------------

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1881 irpwhlvkpsdepepprprrgslrggereraKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTS-RPVPLAVKYFFDLLD 1959
Cdd:cd12205   167 -------------------------------KLIPEIFLTRLLSTKGTLQKFVDDLFESILSVPqRSLPPAIKYLFDFLD 215

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1960 EQAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINKLLYA 2039
Cdd:cd12205   216 EQARKHGISDPDVLHAWKTNSLPLRFWVNIIKNPDFVFDVNKTPTVDSCLSVIAQTFMDACSTSEHKLGKDSPSNKLLFA 295

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 2040 RDIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINKYYDQIITALEEDGTAQKMQLGY 2119
Cdd:cd12205   296 KDIPRYREMVANFYRDISNLPPVSDEEMNSYLAELSESHSGEFNTNVALSELYIYAVKYGDQLLEALEDDREARVQQLAD 375


                  ....*..
gi 194272180 2120 RLQQIAA 2126
Cdd:cd12205   376 KLSQVAR 382
RasGAP_plexin_B2 cd12792
Ras-GTPase Activating Domain of plexin-B2; Plexins form a conserved family of transmembrane ...
 1562-2134 0e+00

Ras-GTPase Activating Domain of plexin-B2; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin-B2 receptor is critically involved in neural tube closure and cerebellar granule cell development. Mice lacking Plexin-B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C and Plexin-B2 signaling modulates ureteric branching. Plexin-B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin-B2 results in renal hypoplasia and occasional double ureters. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213352 [Multi-domain]  Cd Length: 400  Bit Score: 559.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1562 GIPFLDYKVYAERIFF----PGHRESPLHRDLGVPESRRPTVEQGLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYV 1637
Cdd:cd12792     1 RIPFLDYKTYTDRVFFlpskDGANDVMITGKLDIPEARRATVEQALNQFSNLLNSKTFLINFIHTLENQRDFNARAKVYF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1638 ASLLTVALHGKLEYFTDILRTLLSDLVAQYV-AKNPKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKH 1716
Cdd:cd12792    81 ASLLTVALHGKLEYYTDIMRTLLLELMEQYVhSKNPKLMLRRSETVVERMLSNWMSICLYQYLKDTAGEPLYKLFKAIKH 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1717 QVDKGPVDSVTGKakytlndnrllredveyrpltlnallavgpgageaqgvpvkvldcdtisqakekmldqlykgvpltq 1796
Cdd:cd12792   161 QVEKGPVDAVQKK------------------------------------------------------------------- 173

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1797 rpdprtldvewrsgvaghlilsdedvtsevqglwrrlntlqhykvpdgatvalvpcltkhvlrenqdyvpgertpmledv 1876
Cdd:cd12792       --------------------------------------------------------------------------------

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1877 deggirpwhlvkpsdepepprprrgslrggeRERAKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTSRPVPLAVKYFFD 1956
Cdd:cd12792   174 -------------------------------KERTKAITEIYLTRLLSVKGTLQQFVDNFFRSVLCSGAVVPPAVKYFFD 222

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1957 LLDEQAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINKL 2036
Cdd:cd12792   223 FLDEQAEKHDIVDEETIHIWKTNSLPLRFWVNILKNPHFIFDVHVTEVVDASLSVIAQTFMDACTKTEHKLSRDSPSNKL 302

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 2037 LYARDIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINKYYDQIITALEEDGTAQKMQ 2116
Cdd:cd12792   303 LYAKEISTYKKMVDDYYKGIRQMVPVSDQDMNTHLAEISRAHTDKLNTQVALHQLYQYASKYYDEIINSLEEDPAAQSKQ 382

                         570
                  ....*....|....*...
gi 194272180 2117 LGYRLQQIAAAVENKVTD 2134
Cdd:cd12792   383 LTLRLQQIAAALENKVTD 400
Sema_plexin_B3 cd11277
The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of ...
 28-480 7.70e-168

The Sema domain, a protein interacting module, of Plexin B3; Plexin B3 is the receptor of semaphorin 5A. It is a highly potent stimulator of neurite outgrowth of primary murine cerebellar neurons. Plexin B3 has been linked to verbal performance and white matter volume in human brain. Furthermore, Sema5A and plexin B3 have been implicated in the progression of various types of cancer. They play an important role in the invasion and metastasis of gastric carcinoma. The stimulation of plexin B3 by Sema5A binding in human glioma cells results in the inhibition of cell migration and invasion. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200538 [Multi-domain]  Cd Length: 434  Bit Score: 521.29  E-value: 7.70e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   28 FTPNGTYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDECPQAQPTNNPNQLLLVS--P 105
Cdd:cd11277     1 FSAPNATFNHLALDPGSGTLYVGAVNRLYQLSPDLQLLGEAVTGPVLDSPDCLPFRDPADCPQARLTDNANKLLLVSerA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  106 GALVVCGSVHQGVCEQRRLGQLEQLLLRPERPGDTQYVAANDPAVSTVGLVAQgLAGEPLLFVGRGYTSRGvGGGIPPIT 185
Cdd:cd11277    81 GELVACGQVRQGVCEKRRLGNVAQVLYQAEDPGDGQFVAANDPGVATVGLVVE-APGRDLLLVGRGLTGKL-SAGIPPLT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  186 TRALWPPDPqaaFSYEETAKLAVGRLSEYSHHFVSAFARGASAYFLFLRRDLQAQsRAFRAYVSRVCLRDQHYYSYVELP 265
Cdd:cd11277   159 IRQLAGAQA---FSSEGLGKLVVGDFSDYNNSYVGAFAHNGYVYFLFRRRGARAQ-AEYRTYVARVCLGDTNLYSYVEVP 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  266 LACEGGrYGLIQAAAVATsrevaHGEVLFAAFSSAAPPTvgrppsaaAGASGASALCAFPLDEVDRLANRTRDACYTREG 345
Cdd:cd11277   235 LVCQGG-YNLAQAAYLAP-----GQGTLFVVFAAGQGST--------PTPTDQTALCAYPLVELDSAMERARRLCYTAGG 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  346 RAEDGTEVAYIEYDVNSDCAQLPVDTLDAYPCGSDHTPSPMASRVPLEATPILEWpGIQLTAVAVTMEDGHTIAFLGDSQ 425
Cdd:cd11277   301 GGPNGKEEATIEYGVTSRCVNLPKDSPESYPCGDEHTPSPIASRQPLEAEPLLTL-TPPLTAVAALQEDGHTIAFLGDTQ 379

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 194272180  426 GQLHRVYLGpGSDGHPYSTQSI-QQGSAVSRDLTFDGTFEHLYVMTQSTLLKVPVA 480
Cdd:cd11277   380 GQLHKVFLN-GSAGQVYSSQPVgPPGSAVNPDLLLDATGSHLYVLTARQVTKVPVA 434
RasGAP_plexin_A cd12790
Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of ...
 1562-2124 1.17e-159

Ras-GTPase Activating Domain of type A plexins; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. They are divided into four types (A-D) according to sequence similarity. In vertebrates, there are four type A plexins (A1-A4) that serve as the co-receptors for neuropilins to mediate the signaling of class 3 semaphorins except Sema3E, which signals through Plexin-D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 1 and class 6 semaphorins signal through type A plexins, which mediate diverse biological functions including axon guidance, cardiovascular development, and immune function. Guanylyl cyclase Gyc76C and Off-track kinase (OTK), a putative receptor tyrosine kinase, modulate Sema1a and Plexin-A mediated axon repulsion. In their complex with Sema6s, type A plexins serve as signal-transducing subunits. An increasing number of molecules that interact with the intracellular region of Plexin-A have been identified; among them are IgCAMs (in axon guidance events) and Trem2-DAP12 (in immune responses). Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213350 [Multi-domain]  Cd Length: 385  Bit Score: 496.56  E-value: 1.17e-159
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1562 GIPFLDYKVYAERIFFPGHRESPLHRDLGVPESRRPTVEQGLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVASLL 1641
Cdd:cd12790     1 GIPFLDYRTYAMRVLFPGIEDHPVLRELEVERDRQENVEKGLRLFGQLLMNKTFLLTFIRTLESQRSFSMRDRGNVASLI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1642 TVALHGKLEYFTDILRTLLSDLVAQYVAK--NPKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVD 1719
Cdd:cd12790    81 MVVLQSKMEYATDILKQLLADLIEKNLESknHPKLLLRRTESVAEKMLTNWFTFLLYKFLKECAGEPLFMLFCAIKQQME 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1720 KGPVDSVtgkakytlndnrllredveyrpltlnallavgpgageaqgvpvkvldcdtisqakekmldqlykgvpltqrpd 1799
Cdd:cd12790   161 KGPIDAI------------------------------------------------------------------------- 167

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1800 prtldvewrsgvaghlilsdedvtsevqglwrrlntlqhykvpdgatvalvpcltkhvlrenqdyvpgertpmledvdeg 1879
Cdd:cd12790       --------------------------------------------------------------------------------

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1880 girpwhlvkpsdepepprprrgslrggereraKAIPEIYLTRLLSMKGTLQKFVDDLFQVILSTSR---PVPLAVKYFFD 1956
Cdd:cd12790   168 --------------------------------KMVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHrgsALPLAIKYMFD 215

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1957 LLDEQAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINKL 2036
Cdd:cd12790   216 FLDEQADQHGITDPEVVHTWKSNCLPLRFWVNLIKNPQFVFDIHKSSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKL 295

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 2037 LYARDIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINKYYDQIITALEEDGTAQKMQ 2116
Cdd:cd12790   296 LYAKDIPNYKSWVERYYADIAKMPAISDQDMNAYLAEQSRLHLNEFNTLSALNELYSYVTKYKEEILTALEEDEFARKQR 375


                  ....*...
gi 194272180 2117 LGYRLQQI 2124
Cdd:cd12790   376 LAYKLEQV 383
RasGAP_plexin_D1 cd12788
Ras-GTPase Activating Domain of plexin-D1; Plexins form a conserved family of transmembrane ...
 1562-2132 5.67e-143

Ras-GTPase Activating Domain of plexin-D1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-D1 has been identified as the receptor of Sema3E. It binds to Sema3E directly with high affinity. Sema3E is implicated in axonal path finding and inhibition of developmental and postischemic angiogenesis. Plexin-D1 is broadly expressed on tumor vessels and tumor cells in a number of different types of human tumors. The Plexin-D1 and Sema3E interaction inhibits tumor growth but promotes invasiveness and metastasis. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213348 [Multi-domain]  Cd Length: 419  Bit Score: 451.75  E-value: 5.67e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1562 GIPFLDYKVYAERIFFP-----------------------GHRES-PLHRDLGVPESRRPTVEQGLGQLSNLLNSKLFLT 1617
Cdd:cd12788     2 GIPFLEYKHFVTRTFFPkcsslyeeryvlpsqennsqgprQVPEThPLLQEWKIPESCRPNMEEGITLFSTLLNNKHFLV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1618 KFIHTLESQRTFSARDRAYVASLLTVALHGKLEYFTDILRTLLSDLVAQYVAKNPKLMLRRTETVVEKLLTNWMSICLYT 1697
Cdd:cd12788    82 TFVHALEQQKDFAVRDRCNLASLLTIALHGKLEYYTSIMKDLLVDLIDASASKNPKLMLRRTESVVEKMLTNWMSICMYS 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1698 FVRDSVGEPLYMLFRGIKHQVDKGPVDSVTgkakytlndnrllredveyrpltlnallavgpgageaqgvpvkvldcdti 1777
Cdd:cd12788   162 YLRETVGEPFFLLLCAIKQQINKGSIDAIK-------------------------------------------------- 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1778 sqakekmldqlykgvpltqrpdprtldvewrsgvaghlilsdedvtsevqglwrrlntlqhykvpdgatvalvpcltkhv 1857
Cdd:cd12788       --------------------------------------------------------------------------------

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1858 lrenqdyvpgertpmledvdeggirpwhlvkpsdepepprprrgslrggereraKAIPEIYLTRLLSMKGTLQKFVDDLF 1937
Cdd:cd12788   192 ------------------------------------------------------KVLPEIYLTRLLSTKGTLQKFLDDLF 217

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1938 QVILST--SRPvPLAVKYFFDLLDEQAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQT 2015
Cdd:cd12788   218 QAILSIpeDRP-PLAVKYFFDFLEEQAEKRGITDPDTLHIWKTNSLPLRFWVNILKNPQFVFDIDKTDHMDACLSVIAQA 296

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 2016 FMDACTLADHKLGRDSPINKLLYARDIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYI 2095
Cdd:cd12788   297 FIDACSISDLQLGKDSPTNKLLYAKEIPEYRKIVQRYYQQIQEMPPLSEQEMNAHLAEESRKYRNEFNTNVAMAEIYKYA 376

                         570       580       590
                  ....*....|....*....|....*....|....*..
gi 194272180 2096 NKYYDQIITALEEDGTAQKMQLGYRLQQIAAAVENKV 2132
Cdd:cd12788   377 KRYRAQIVSALESNPTARRTQLQHKFEQVIALMEDNI 413
Sema_plexin_like cd11236
The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine ...
 34-480 3.94e-124

The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine kinases; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestor of semaphorins. Ligand binding activates signal transduction pathways controlling axon guidance in the nervous system and other developmental processes including cell migration and morphogenesis, immune function, and tumor progression. Plexins are divided into four types (A-D) according to sequence similarity. In vertebrates, type A Plexins serve as the co-receptors for neuropilins to mediate the signalling of class 3 semaphorins except Sema3E, which signals through Plexin D1. Plexins serve as direct receptors for several other members of the semaphorin family: class 6 semaphorins signal through type A plexins and class 4 semaphorins through type B. Plexin C1 serves as the receptor of Sema7A and plays regulation roles in both immune and nervous systems. This family also includes the Met and RON receptor tyrosine kinases. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200497 [Multi-domain]  Cd Length: 401  Bit Score: 397.47  E-value: 3.94e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   34 YLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDECPQAQPTNNPNQLLLVSPGA--LVVC 111
Cdd:cd11236     1 PFNHLAVDNSTGRVYVGAVNRLYQLDSSLLLEAEVSTGPVLDSPLCLPPGCCSCDHPRSPTDNYNKILLIDYSSgrLITC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  112 GSVHQGVCEQRRLGQLEQLLLRperpgDTQYVAANDPAVSTVGLVAQG-LAGEPLLFVGRGYTSRGVGGGIPPITTRALW 190
Cdd:cd11236    81 GSLYQGVCQLRNLSNISVVVER-----SSTPVAANDPNASTVGFVGPGpYNNENVLYVGATYTNNGYRDYRPAVSSRSLP 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  191 PPDPQAAFSYEETAKLAVGRLS--EYSHHFVSAFARGASAYFLFLRRDLQAQSRAFRAYVSRVCLRDQHYYSYVELPLAC 268
Cdd:cd11236   156 PDDDFNAGSLTGGSAISIDDEYrdRYSIKYVYGFSSGGFSYFVTVQRKSVDDESPYISRLVRVCQSDSNYYSYTEVPLQC 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  269 EGG---RYGLIQAAAVATSREV--------AHGEVLFAAFSSAAPPTVGRPpsaaagasGASALCAFPLDEVDRLANRTr 337
Cdd:cd11236   236 TGGdgtNYNLLQAAYVGKAGSDlarslgisTDDDVLFGVFSKSKGPSAEPS--------SKSALCVFSMKDIEAAFNDN- 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  338 dacytregraedgtevayieydvnsdcaqlpvdtldaypcgsdhtpSPMASRVPLEATPILewPGIQLTAVAVTMEDGHT 417
Cdd:cd11236   307 ----------------------------------------------CPLGGGVPITTSAVL--SDSLLTSVAVTTTRNHT 338

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194272180  418 IAFLGDSQGQLHRVYLGPGSDGHPYSTQSIQQGSAVSRDLTFDGTFEHLYVMTQSTLLKVPVA 480
Cdd:cd11236   339 VAFLGTSDGQLKKVVLESSSSATQYETLLVDSGSPILPDMVFDPDGEHLYVMTPKKVTKVPVE 401
RasGAP_plexin_C1 cd12789
Ras-GTPase Activating Domain of plexin-C1; Plexins form a conserved family of transmembrane ...
 1563-2131 2.84e-115

Ras-GTPase Activating Domain of plexin-C1; Plexins form a conserved family of transmembrane receptors for semaphorins and may be the ancestors of semaphorins. Plexins are divided into four types (A-D) according to sequence similarity. Plexin-C1 has been identified as the receptor of semaphorin 7A, which plays regulatory roles in both the immune and nervous systems. Unlike other semaphorins which act as repulsive guidance cues, Sema7A enhances central and peripheral axon growth and is required for proper axon tract formation during embryonic development. Plexin-C1 is a potential tumor suppressor for melanoma progression. The expression of Plexin-C1 is diminished or absent in human melanoma cell lines. Cofilin, an actin-binding protein involved in cell migration, is a downstream target of Sema7A and Plexin-C1 signaling. Melanoma invasion and metastasis may be promoted through the loss of Plexin-C1 inhibitory signaling on cofilin activation. Plexins contain a C-terminal RasGAP domain, which functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Plexins display GAP activity towards the Ras homolog Rap. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP show no sequence homology at their amino acid level. RasGTPases function as molecular switches in a large number of of signaling pathways. When bound to GTP they are in the on state and when bound to GDP they are in the off state. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213349 [Multi-domain]  Cd Length: 393  Bit Score: 371.89  E-value: 2.84e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1563 IPFLDYKVYAERIFFPGHRESPLHRDLGVPESRRPT-VEQGLGQLSNLLNSKLFLTKFIHTLESQRTFSARDRAYVASLL 1641
Cdd:cd12789     4 VPFLDYKHFALRTFFPESGGFTHIFTRDDPHDRDQTdKDESLTALDKLICNKSFLVTLIHTLEKQKNFSVKDRCLFASFL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1642 TVALHGKLEYFTDILRTLLSDLVAQYVAKNPKLMLRRTETVVEKLLTNWMSICLYTFVRDSVGEPLYMLFRGIKHQVDKG 1721
Cdd:cd12789    84 TIALQTKLVYLTEILEVLTKDLMDQSSNAQPKLLLRRTESVVEKLLTNWMSVCLSGFLRETVGEPFYLLVTTLNQKINKG 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1722 PVDSVTGKAKytlndnrllredveyrpltlnallavgpgageaqgvpvkvldcdtisqakekmldqlykgvpltqrpdpr 1801
Cdd:cd12789   164 PVDVIKFKVK---------------------------------------------------------------------- 173

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1802 tldvewrsgvaghlilsdedvtsevqglwrrlntlqhykvpdgatvalvpcltkhvlrenqdyvpgertpmledvdeggi 1881
Cdd:cd12789       --------------------------------------------------------------------------------

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1882 rpwhlvkpsdepepprprrgslrggererakaipEIYLTRLLSMKGTLQKFVDDLFQVI--LSTSRPvPLAVKYFFDLLD 1959
Cdd:cd12789   174 ----------------------------------EMYLTKLLSTKVAIHSVVEKLFRSIwsLPNNKA-PVAIKYFFDFLD 218

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1960 EQAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQFVFDVQTSDNMDAVLLVIAQTFMDACTLADHKLGRDSPINKLLYA 2039
Cdd:cd12789   219 AQAENKKITDPDVLHIWKTNSLPLRFWVNILKNPQFVFDIKKTPHLDGCLSVIAQAFMDSFSLSEQHLGKEAPTNKLLYA 298

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 2040 RDIPRYKRMVERYYADIRQTVPASDQEMNSVLAELSWNYSGDLGARVALHELYKYINKYYDQIITALE-EDGTAQKMQlg 2118
Cdd:cd12789   299 KDIPQYKEEVKSYYKAIRDLPPLSSSELEEFLTQESKKHENEFNEEVALMEIYKYIVKYFDEILNKLErERGLEEVQK-- 376

                         570
                  ....*....|...
gi 194272180 2119 yRLQQIAAAVENK 2131
Cdd:cd12789   377 -QLLHVKALFDEK 388
Sema_plexin_B2 cd11276
The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor ...
 33-479 1.89e-106

The Sema domain, a protein interacting module, of Plexin B2; Plexin B2 serves as the receptor of Sema4C and Sema4G. By signaling the effect of Sema4C and Sema4G, the plexin B2 receptor plays important roles in neural tube closure and cerebellar granule cell development. Mice lacking Plexin B2 demonstrated defects in closure of the neural tube and disorganization of the embryonic brain. In developing kidney, Sema4C-Plexin B2 signaling modulates ureteric branching. Plexin B2 is expressed both in the pretubular aggregates and the ureteric epithelium in the developing kidney. Deletion of Plexin B2 results in renal hypoplasia and occasional double ureters. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200537 [Multi-domain]  Cd Length: 449  Bit Score: 348.69  E-value: 1.89e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   33 TYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDECPQAQPTNNPNQLLLVSP--GALVV 110
Cdd:cd11276     6 TELNHLVVDPQTGRVYLGAVNALYQLDADLQLESRVETGPKKDNKKCTPPIEENQCTEAKMTDNYNKLLLLDSanKTLVV 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  111 CGSVHQGVCEQRRLGQLEQLLLRPERPGDTQYVAANDPAVSTVGLVAQ-GLAGEPLLFVGRGYTSRGVGggiPPITTRAL 189
Cdd:cd11276    86 CGSLFKGICSLRNLSNISEVIYYSDTSGEKSFVASNDEGVSTVGLISSlKPGNDRVFFVGKGNGSNDNG---KIISTRLL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  190 WPPDPQAAF-SYEETAKLAVGRLSEYSHHFVSAFARGASAYFLFLRRDlqAQSRAFRAYVSRVCLRDQHYYSYVELPLAC 268
Cdd:cd11276   163 QNYDDREVFeNYIDAATVKSAYVSRYTQQFRYAFEDNNYVYFLFNQQL--GHPDKNRTLIARLCENDHHYYSYTEMDLNC 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  269 --EGGRYGLIQAAAVATSREV---------AHGEVLFAAFSSAAPPTVGrppsaaagasgaSALCAFPLDEVDRLANRTR 337
Cdd:cd11276   241 rdGANAYNKCQAAYVSTPGKElaqnygnsiLSDKVLFAVFSRDEKDSGE------------SALCMFPLKSINAKMEANR 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  338 DACYTREgraEDGTEVAYIEY--DVNSDCAQLPVDTLDAYPCGSDHTPSPMASRVPL-EATPILEWPGIQLTAVAVTMED 414
Cdd:cd11276   309 EACYTGT---IDDRDVFYKPFhsQKDIICGSHQQKNSKSFPCGSEHLPYPLGSRDELaLTAPVLQRGGLNLTAVTVAVEN 385

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194272180  415 GHTIAFLGDSQGQLHRVYLGPGSDghPYSTQSIQQGSAVSRDLTFDGTFEHLYVMTQSTLLKVPV 479
Cdd:cd11276   386 GHTVAFLGTSDGRILKVHLSPDPE--EYNSILIEKNKPVNKDLVLDKTLEHLYIMTEDKVFRLPV 448
Sema smart00630
semaphorin domain;
35-454 7.83e-82

semaphorin domain;


Pssm-ID: 214747 [Multi-domain]  Cd Length: 390  Bit Score: 275.40  E-value: 7.83e-82
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180     35 LQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPdecPQAQPTNNPNQLLLV---SPGALVVC 111
Cdd:smart00630    1 LQHLLLDEDNGTLYVGARNRLYQLSLNLILEAELKTGPVLSSPDCEECVSK---GKDPPTDCVNYIRLLldyNEDRLLVC 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180    112 GS-VHQGVCEQRRLGQLeqlllrperpgdtqyvaandpavstvglvaqglagepllFVGRGYTSRGVGGGIPPITTralW 190
Cdd:smart00630   78 GTnAFQPVCRLRNLGEL---------------------------------------YVGTVADFSGSDPAIPRSLS---V 115

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180    191 PPDPQAAFSYEETAKLAVGRLseYSHHFVSAFARGASAYFLFLRR--DLQAQSRAFRAYVSRVCLRD--------QHYYS 260
Cdd:smart00630  116 RRLKGTSGVSLRTVLYDSKWL--NEPNFVYAFESGDFVYFFFRETavEDDNCGKAVHSRVARVCKNDvggprsldKKWTS 193

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180    261 YVELPLACEGG-----RYGLIQAAAVATSREVaHGEVLFAAFSSAAPPTVGrppsaaagasgaSALCAFPLDEVDRLANR 335
Cdd:smart00630  194 FLKARLECSVPgedpfYFNELQAAFLLPPGSE-SDDVLYGVFSTSSNPIPG------------SAVCAFSLSDINAVFNG 260

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180    336 TRDACYTREGRAEDGTEvAYIEYDVNSDCAQLPVDTLDaYPC----GSDHTPSPMASRVPLEATPIL--EWPGIQLTAVA 409
Cdd:smart00630  261 PFKECETSTSQWLPYSR-GKVPYPRPGTCPNKPPSSKD-LPDetlnFIKSHPLMDEVVQPLTGRPLFvkTDSNYLLTSIA 338

                           410       420       430       440       450
                    ....*....|....*....|....*....|....*....|....*....|..
gi 194272180    410 VTMED---GHTIAFLGDSQGQLHRVYLGPGSDGHP---YSTQSIQQ-GSAVS 454
Cdd:smart00630  339 VDRVAtdgNYTVLFLGTSDGRILKVVLSESSSSSEsvvLEEISVFPdGSPIS 390
Sema_plexin_A2 cd11272
The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor ...
 35-520 1.71e-64

The Sema domain, a protein interacting module, of Plexin A2; Plexin A2 serves as a receptor for class 6 semaphorins. Interactions between Plexin A2, A4 and semaphorins 6A and 6B control the lamina-restricted projection of hippocampal mossy fibers. Sema6B also repels the growth of mossy fibers in a Plexin A4 dependent manner. Plexin A2 does not suppress Sema6B function. In addition, studies have shown that Plexin A2 may be related to anxiety and other psychiatric disorders. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200533 [Multi-domain]  Cd Length: 515  Bit Score: 229.43  E-value: 1.71e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   35 LQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDECPQAQP-TNNPNQLLLV--SPGALVVC 111
Cdd:cd11272    13 FNHLTVHQSTGAVYVGAINRVYKLSGNLTILVAHKTGPEEDNKSCYPPLIVQPCSEVLTlTNNVNKLLIIdySENRLLAC 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  112 GSVHQGVCEQRRLGQLeQLLLRPERPGDtQYVAANDPAVSTVGLVAQGLAGEPLLFVGRGytsrgVGGG---IPPITTRA 188
Cdd:cd11272    93 GSLYQGVCKLLRLDDL-FILVEPSHKKE-HYLSSVNKTGTMYGVIVRSEGEDGKLFIGTA-----VDGKqdyFPTLSSRK 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  189 LwPPDPQ--AAFSYE-------ETAKLAVGRLSEYSH---HFVSAFARGASAYFLFLRRDL-------QAQSRAFRAYVS 249
Cdd:cd11272   166 L-PRDPEssAMLDYElhsdfvsSLIKIPSDTLALVSHfdiFYIYGFASGNFVYFLTVQPETpegvsinSAGDLFYTSRIV 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  250 RVCLRDQHYYSYVELPLAC--EGGRYGLIQAAAVATSREV--------AHGEVLFAAFSSAAPpTVGRPPSAAAgasgas 319
Cdd:cd11272   245 RLCKDDPKFHSYVSLPFGCvrGGVEYRLLQAAYLSKPGEVlarslnitAQEDVLFAIFSKGQK-QYHHPPDDSA------ 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  320 aLCAFPLDEVDRLANRTRDACYTREGRAEdgtevayIEYDVNSD--CAQLPVDTLDAYpCGSDhTPSPMASRVPLEATPI 397
Cdd:cd11272   318 -LCAFPIRAINAQIKERLQSCYQGEGNLE-------LNWLLGKDvqCTKAPVPIDDNF-CGLD-INQPLGGSTPVEGVTL 387

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  398 LEWPGIQLTAVAVTMEDGHTIAFLGDSQGQLHRVYL-GPGSDGHPYSTQSI-QQGSAVSRDLTFDGTFEHLYVMTQSTLL 475
Cdd:cd11272   388 YTSSRDRLTSVASYVYNGYSVVFVGTKSGKLKKIRAdGPPHGGVQYEMVSVfKDGSPILRDMAFSIDHKYLYVMSERQVS 467

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 194272180  476 KVPVASCAQHLDCASCLAHRDPYCGWCVLLGRCSRRSECSRGQGP 520
Cdd:cd11272   468 RVPVESCEQYTTCGECLSSGDPHCGWCALHNMCSRRDKCQRAWEP 512
Plexin_RBD pfam20170
Plexin cytoplasmic RhoGTPase-binding domain; This entry represents the RhoGTPase-binding ...
 1734-1849 3.24e-55

Plexin cytoplasmic RhoGTPase-binding domain; This entry represents the RhoGTPase-binding domain found in the cytoplasmic domain of plexins.


Pssm-ID: 466321  Cd Length: 113  Bit Score: 187.79  E-value: 3.24e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  1734 LNDNRLLREDVEYRPLTLNALLAVGpgaGEAQGVPVKVLDCDTISQAKEKMLDQLYKGVPLTQRPDPRTLDVEWRSGVAG 1813
Cdd:pfam20170    1 LSEDKLLREQIDYKTLTLNVIFEEG---EVSESVPVKVLDCDTISQVKEKILDAVYKNTPYSQRPSIDDVDLEWRHGRGG 77

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 194272180  1814 HLILSDEDVTSEVQGLWRRLNTLQHYKVPDGATVAL 1849
Cdd:pfam20170   78 RLILQDEDSTSKVEGGWKKLNTLAHYKVPDGATLAL 113
Sema_plexin_A cd11244
The Sema domain, a protein interacting module, of Plexin A; Plexins serve as receptors of ...
 25-479 7.42e-52

The Sema domain, a protein interacting module, of Plexin A; Plexins serve as receptors of semaphorins and may be the ancestor of semaphorins. Members of the Plexin A subfamily are receptors for Sema1s, Sema3s, and Sema6s, and they mediate diverse biological functions including axon guidance, cardiovascular development, and immune function. Guanylyl cyclase Gyc76C and Off-track kinase (OTK), a putative receptor tyrosine kinase, modulate Sema1a-Plexin A mediated axon repulsion. Sema3s do not interact directly with plexin A receptors, but instead bind Neuropilin-1 or Neuropilin-2 toactivate neuropilin-plexin A holoreceptor complexes. In contrast to Sema3s, Sema6s do not require neuropilins for plexin A binding. In the complex, plexin As serve as signal-transducing subunits. An increasing number of molecules that interact with the intracellular region of Plexin A have been identified; among them are IgCAMs (in axon guidance events) and Trem2-DAP12 (in immune responses). The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200505 [Multi-domain]  Cd Length: 470  Bit Score: 191.19  E-value: 7.42e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   25 PTAFTPNGTYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDECPQA-QPTNNPNQLLLV 103
Cdd:cd11244     3 TFRGEPRDWSFNHLTVHRRTGEVYVGAINRVYKLSSNLTVLVTHETGPVEDNPKCYPPPIVQTCNEPlTTTNNVNKLLLI 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  104 --SPGALVVCGSVHQGVCEQRRLGQLEQLLLRPERpgDTQYVAANDPAVSTVGLVAQGLAGEPLLFVGRGYTsrGVGGGI 181
Cdd:cd11244    83 dySENRLIACGSLYQGVCKLLRLEDLFKLGEPHHK--KEHYLSGVNESGTMFGVIVSYSNGDDKLFIGTAVD--GKSEYF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  182 PPITTRALwPPDPQAA--FSYE-------ETAKLAVGRLSEYSH---HFVSAFARGASAYFLFLRRDLQ------AQSRA 243
Cdd:cd11244   159 PTLSSRKL-TADEESDgmFAYVyhdefvsSQIKIPSDTLSIIPDfdiYYVYGFSSGNFVYFLTLQPETQltpgdsTGEQF 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  244 FRAYVSRVCLRDQHYYSYVELPLACE--GGRYGLIQAAAVATSREV--------AHGEVLFAAFSSAAPPTVgRPPsaaa 313
Cdd:cd11244   238 YTSKIVRLCKDDTKFYSYVEFPIGCTrdGVEYRLLQAAYLSKPGKAlaqalgisEDEDVLFTIFSKGQKNRM-KPP---- 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  314 gasGASALCAFPLDEV-DRLANRTRdACYTREGRAEdgtevayIEYDVNSD--CAQLPVDTLDAYpCGSDHTpSPMASRV 390
Cdd:cd11244   313 ---DESALCLFTLKQInLRIKERLQ-SCYRGEGKLS-------LPWLLNKDlpCINAPLQIDDNF-CGLDMN-QPLGGSD 379

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  391 PLEATPILEWPGIQLTAVAVTMEDGHTIAFLGDSQGQLHRVYL-GPGSDGHPYSTQSIQQGSAVSRDLTFDGTFEHLYVM 469
Cdd:cd11244   380 MVEGIPLFTDDRDRMTSVAAYVYKGHSVVFVGTKSGKLKKIRVdGPPHNALQYETVQVVEGSPILRDMAFSPDHQYLYIM 459

                         490
                  ....*....|
gi 194272180  470 TQSTLLKVPV 479
Cdd:cd11244   460 SERQVTRVPV 469
Sema_plexin_A1 cd11271
The Sema domain, a protein interacting module, of Plexin A1; Plexin A1 is found in both the ...
 22-479 4.15e-50

The Sema domain, a protein interacting module, of Plexin A1; Plexin A1 is found in both the nervous and immune systems. Its external Sema domain is also shared by semaphorin proteins. In the nervous system, Plexin A1 mediates Sema3A axon guidance function by interacting with the Sema3A coreceptor neuropilin, resulting in actin depolarization and cell repulsion. In the immune system, Plexin A1 mediates Sema6D signaling by binding to the Sema6D-Trem2-DAP12 complex on immune cells and osteoclasts to promote Rac activation and DAP12 phosphorylation. In gene profiling experiments, Plexin A1 was identified as a CIITA (class II transactivator) regulated gene in primary dendritic cells (DCs). The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200532 [Multi-domain]  Cd Length: 474  Bit Score: 185.94  E-value: 4.15e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   22 PLPPTAFTPNGTYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDECPQA-QPTNNPNQL 100
Cdd:cd11271     1 QPPFRTFTASDWSLTHLVVHNKTGEVYVGAVNRIYKLSNNLTLLRTHVTGPVEDNEKCYPPPSVQSCPHGlGTTNNVNKL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  101 LLV--SPGALVVCGSVHQGVCEQRRLGQLEQLLLRPERpgDTQYVAANDPAVSTVGLVAQGLAGEPLLFVGRGYTsrGVG 178
Cdd:cd11271    81 LLVdyAANRLIACGSASQGICQFLRLDDLFKLGEPHHR--KEHYLSSVNESGTMSGVIIEVGNGQNKLFVGTPID--GKS 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  179 GGIPPITTRALWPPDPQA---AFSYEE---TAKLAV-----GRLSEYSHHFVSAFARGASAYFLFLRRDLQAQS------ 241
Cdd:cd11271   157 EYFPTLSSRKLMANEENAemfGFVYQDefvSSQLKIpsdtlSKFPTFDIYYVYSFSSEQFVYYLTLQLDTQLTSpdstge 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  242 RAFRAYVSRVCLRDQHYYSYVELPLACE--GGRYGLIQAA-------AVATSREVAHGE-VLFAAFSSAAPPTVgRPPsa 311
Cdd:cd11271   237 QFFTSKIVRLCVDDPKFYSYVEFPIGCEqdGVEYRLIQDAylskpgkALAKQLGISEREdILFTVFSQGQKNRV-KPP-- 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  312 aagasGASALCAFPLDEV-DRLANRTRdACYTREGRAEdgtevayIEYDVNSD--CAQLPVDTLDAYpCGSDHTpSPMAS 388
Cdd:cd11271   314 -----KESVLCLFTLKKIkDKIKERIQ-SCYRGEGKLS-------LPWLLNKElgCINSPLQIDDNF-CGQDFN-QPLGG 378

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  389 RVPLEATPILEWPGIQLTAVAVTMEDGHTIAFLGDSQGQLHRVYLG-PGSDGHP---YSTQSIQQGSAVSRDLTFDGTFE 464
Cdd:cd11271   379 TVTIEGTPLFVDKEDGMTSVAAYDYRGRTVVFAGTRSGRIKKILVDlSAPSSRPalqYENVVAHEGSPILRDLVLSPDRQ 458

                         490
                  ....*....|....*
gi 194272180  465 HLYVMTQSTLLKVPV 479
Cdd:cd11271   459 YIYAMTEKQVTRVPV 473
Sema_plexin_A3 cd11273
The Sema domain, a protein interacting module, of Plexin A3; Plexin-A3 forms a receptor ...
 24-479 4.63e-49

The Sema domain, a protein interacting module, of Plexin A3; Plexin-A3 forms a receptor complex with neuropilin-2 and transduces signals for class 3 semaphorins in the nervous system. Both plexins A3 and A4 are essential for normal sympathetic neuron development. They function cooperatively to regulate the migration of sympathetic neurons, and differentially to guide sympathetic axons. Both plexins A3 and A4 are not required for guiding neural crest precursors prior to reaching the sympathetic anlagen. Plexin A3 is a major driving force for intraspinal motor growth cone guidance. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200534 [Multi-domain]  Cd Length: 469  Bit Score: 182.83  E-value: 4.63e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   24 PPTAFTPNGTYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDECPQA-QPTNNPNQLLL 102
Cdd:cd11273     2 PFRAFVVTDTTLTHLAVHRVTGEVFVGAVNRVYKLSANLTELRAHVTGPVEDNARCYPPPSVRVCAHRlAPVDNVNKLLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  103 VSPGA--LVVCGSVHQGVCEQRRLGQLEQLLLRPERpgDTQYVAANDPAVSTVGLVAQGLAGEPLLFVGRGytsrgVGGG 180
Cdd:cd11273    82 VDYAGnrLVACGSIWQGVCQFLRLEDLFKLGEPHHR--KEHYLSGAQEPDSMAGVIVEQGKGPSKLFVGTA-----IDGK 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  181 ---IPPITTRALWPPDPQA-AFS--YEE-----TAKLAVGRLSEYSH---HFVSAFARGASAYFLFLRRDLQ------AQ 240
Cdd:cd11273   155 seyFPTLSSRKLISDEDSAdMFSlvYQDefvssQIKIPSDTLSLYPAfdiYYVYGFVSASFVYFLTLQLDTQqtlldtAG 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  241 SRAFRAYVSRVCLRDQHYYSYVELPLAC--EGGRYGLIQAA-------AVATSREVAHGE-VLFAAFSS-----AAPPtv 305
Cdd:cd11273   235 EKFFTSKIVRMCANDTEFYSYVEFPLGCskDGVEYRLVQAAhlakpglLLAQALGVPEDEdVLFTIFSQgqknrASPP-- 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  306 grppsaaagasGASALCAFPLDEVDRLANRTRDACYTREGRAEdgtevayIEYDVNSD--CAQLPVDTLDAYpCGSDHTp 383
Cdd:cd11273   313 -----------RETILCLFTLSNINAHIRERIQSCYRGEGTLS-------LPWLLNKElpCINTPMQINGNF-CGLVLN- 372

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  384 SPMASRVPLEATPILEWPGIQLTAVAVTMEDGHTIAFLGDSQGQLHRVYLGPGSDGHPYSTQSIQQGSAVSRDLTFDGTF 463
Cdd:cd11273   373 QPLGGLHVIEGLPLLADSTDGMASVAAYTYRQHSVVFIGTRSGSLKKVRVDGFQDAHLYETVPVVDGSPILRDMVFSPDH 452

                         490
                  ....*....|....*.
gi 194272180  464 EHLYVMTQSTLLKVPV 479
Cdd:cd11273   453 RYIYLLSEKQVSQLPV 468
Sema_plexin_A4 cd11274
The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor ...
 30-482 5.54e-45

The Sema domain, a protein interacting module, of Plexin A4; Plexin A4 forms a receptor complex with neuropilins (NRPs) and transduces signals for class 3 semaphorins in the nervous system. It regulates facial nerve development by functioning as a receptor for Sema3A/NRP1. Both plexins A3 and A4 are essential for normal sympathetic development. They function both cooperatively, to regulate the migration of sympathetic neurons, and differentially, to guide sympathetic axons. Plexin A4 is also expressed in lymphoid tissues and functions in the immune system. It negatively regulates T lymphocyte responses. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200535 [Multi-domain]  Cd Length: 473  Bit Score: 170.90  E-value: 5.54e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   30 PNGTYlQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPVMPDEC-PQAQPTNNPNQLLLVS--PG 106
Cdd:cd11274     9 TEWTF-NHLVVDERTGHIYLGAVNRIYKLSSDLKVLVTHQTGPDEDNPKCYPPRIVQTCnEPLTLTNNINKMLLIDykEN 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  107 ALVVCGSVHQGVCEQRRLGQLEQlLLRPERPGDtQYVAANDPAVSTVGLVAQGLAGEPLLFVGRGYTsrGVGGGIPPITT 186
Cdd:cd11274    88 RLIACGSLYQGICKLLRLDDLFK-LGEPFHKKE-HYLSGVNESGSVFGVIVSYSNLDDKLFIATAVD--GKPEYFPTISS 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  187 RALWP-PDPQAAFSY----EETAKL------AVGRLSEYSHHFVSAFARGASAYFLFLRRDL------QAQSRAFRAYVS 249
Cdd:cd11274   164 RKLTKnSEADGMFAYvfhdEFVASMikipsdTFTIIPDFDIYYIYGFSSGNFVYFLTLQPEMisppgsTTKEQVYTSKLV 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  250 RVCLRDQHYYSYVELPLACE--GGRYGLIQAAAVATS-----REVAHG---EVLFAAFSSAApptvgrppSAAAGASGAS 319
Cdd:cd11274   244 RLCKEDTAFNSYVEVPIGCEknGVEYRLLQAAYLSKAgailaRSLGVGpddDILFTVFSKGQ--------KRKMKSLDES 315

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  320 ALCAFPLDEV-DRLANRTRdACYtregRAEDGTEVAYIEY-DVNSDCAQLPVDtlDAYpCGSDHTpSPMASRVPLEATPI 397
Cdd:cd11274   316 ALCIFVLKEInDRIKDRLQ-SCY----RGEGTLDLAWLKVkDIPCSSALLTID--DNF-CGLDMN-APLGVSEMVRGLPV 386

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  398 LEWPGIQLTAVAVTMEDGHTIAFLGDSQGQLHRVYL-GPGSDGHPYSTQSIQQGSAVSRDLTFDGTFEHLYVMTQSTLLK 476
Cdd:cd11274   387 FTEDRDRMTSVIAYVYKNHSLAFVGTKSGKLKKIRVdGTTKNALQYETVQVVDTGPILRDMAFSKDHEQLYIMSEKQLTR 466


                  ....*.
gi 194272180  477 VPVASC 482
Cdd:cd11274   467 VPVESC 472
Sema_plexin_D1 cd11247
The Sema domain, a protein interacting module, of Plexin D1; Plexins are known as semaphorin ...
 39-480 1.57e-43

The Sema domain, a protein interacting module, of Plexin D1; Plexins are known as semaphorin receptors and Plexin D1 has been identified as the receptor of Sema3E. It binds to Sema3E directly with high affinity. Sema3E is implicated in axonal path finding and inhibition of developmental and post-ischemic angiogenesis. Plexin D1 is broadly expressed on tumor vessels and tumor cells in a number of different types of human tumors. Plexin D1-Sema3E interaction inhibits tumor growth but promotes invasiveness and metastasis. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a ligand-recognition and -binding module.


Pssm-ID: 200508 [Multi-domain]  Cd Length: 483  Bit Score: 166.95  E-value: 1.57e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   39 ARDPTSGTLYLGATNFLFQLSPG-LQLEATVSTGPVLDSRDCLPPVMPDE-CPQAQP-TNNPNQLLLVSP--GALVVCGS 113
Cdd:cd11247    15 ALDGGRGRLYLAAVNRLYQLSGLvLALEAEAAVGPVLDSPLCHAPQLPQAtCEHPRTlTDNYNKILQPDPeqGVLVVCGS 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  114 VHQGVCEQRRLGQLEQLLLRPERPGDTQY-----VAANDPAVSTVGLVA--QGLAGEPLLFVGRGYTSRGVGG------- 179
Cdd:cd11247    95 IYQGLCQLRRLYNISAVAVRFPVDGDTVFpsmlnVAANHPNASTVGLVLwpRGGGGGLRLLVGATYTGYGSGFfprnrsl 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  180 ------GIPPITTRAL-------------WPPDPQAAFSYEETAKlAVGRLSeyshhFVSAFARGASAYFLFLRRDLQA- 239
Cdd:cd11247   175 edhrfeNTPEIAIRALntrgdlaklftfdINPSDDNIFKIKQGAK-ARHKLS-----FVRAFLQHFLQPYAYLAMNGEAn 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  240 ----QSRAfRAYVSRVCLRDQH----------YYSYVELPLACEGGrYGLIQAAAVATSREvahgEVLFAAFSSAAPptv 305
Cdd:cd11247   249 aagkESQP-PSLLARICLPGRAppppgeakklTESYIQLGLRCEGA-YTRLVSVFPARVEE----EQLFAVFERAGG--- 319

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  306 grppsaaagasGASALCAFPLDEVDRLANRTRDACYtrEGRAEDgtEVAYIEYDVNSDCA--------QLPVDTLDaypC 377
Cdd:cd11247   320 -----------APAALCAFRFAEVEEPIRAARTACF--VSPAAG--VVTVLDSVVQGTGPacerklniQLQPEQLD---C 381

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  378 GSDHTPSPMASRVPLEATPILEWPGiqLTAVAVTMEDGHTIAFLGDSQGQLHRVYLGPGSDGHPYSTQSIQQGSAVSRDL 457
Cdd:cd11247   382 GAAHLQHPLAILQPLKATPVFRAPG--LTSVAVASVNNYTVVFLGTVSGRLLKINLDESMQVVSRRSVTVAYGEPVHHVM 459

                         490       500
                  ....*....|....*....|....
gi 194272180  458 TFDGTFE-HLYVMTQSTLLKVPVA 480
Cdd:cd11247   460 QFDPSDStYLYLMTSHQMTRVKVA 483
TIG_2 pfam18020
TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG ...
 921-1020 7.31e-34

TIG domain found in plexin; This entry represents a TIG domain found in plexin proteins. TIG domains have an Ig-like fold.


Pssm-ID: 465619  Cd Length: 94  Bit Score: 126.24  E-value: 7.31e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   921 GSTLMPVHVEREIRLLGRNLHLFQDGPGDNECVMELEGLEVVVEARVECEPppdtqcHVTCQQHQLSYEALQPELRVGLF 1000
Cdd:pfam18020    1 GSILVPVGVEREITLKARNLPLFQSGQLGYECVFEIEGATHVVPASRESSD------SITCQEHQFSYSGSSGELPATFY 74

                           90       100
                   ....*....|....*....|
gi 194272180  1001 LRRAGRLRVDSAEGLHVVLY 1020
Cdd:pfam18020   75 VTWNGGHRLDNPANLQVVLY 94
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1070-1161 2.57e-33

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 124.35  E-value: 2.57e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1070 PLIHSVEPLTGPVDGGTRVTIRGSNLGQHVQDVLGMVTVAGVPCAVDAQEYEVSSSLVCITGASGEEVaGATAVEVPGRG 1149
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRHGVRVGGVPCNPEPPEYSSSEKIVCTTGPAGNPV-FNGPVEVTVGH 79

                          90
                  ....*....|....*
gi 194272180 1150 ---RGVSEHDFAYQD 1161
Cdd:cd01180    80 gsfRTESSEGFSFVD 94
IPT_plexin_repeat3 cd01181
Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1252-1376 4.40e-32

Third repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238586  Cd Length: 99  Bit Score: 121.37  E-value: 4.40e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1252 PNITSAGPTKSFLSGGREICVRGQNLDVVQTPRIRVTVVSRmlqpsqglgrrrrvvpetacslgpscssqqFEEPCHVNS 1331
Cdd:cd01181     1 PTITRIEPEWSFLSGGTPITVTGTNLNTVQEPRIRVKYGGV------------------------------EKTSCKVRN 50

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 194272180 1332 SQLITCRTPALPGLP---EDPWVRVEFILDNLVF-DFATLNPTPFSYEA 1376
Cdd:cd01181    51 STLMTCPAPSLALLNrspEPGERPVEFGLDGDNVqSLLILNRTSFSYYP 99
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1162-1249 4.36e-27

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 106.54  E-value: 4.36e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1162 PKVHSIFPARGPRAGGTRLTLNGSKLLTGRleDIRVVVGDQPCHLLPeQQSEQLRCETSPRPTPATLPVAVWFGATeRRL 1241
Cdd:cd01179     1 PSITSLSPSYGPQSGGTRLTITGKHLNAGS--SVRVTVGGQPCKILS-VSSSQIVCLTPPSASPGEAPVKVLIDGA-RRL 76


                  ....*...
gi 194272180 1242 QRGQFKYT 1249
Cdd:cd01179    77 APLVFTYT 84
TIG_plexin pfam17960
TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and ...
 541-627 1.43e-26

TIG domain; This entry represents an TIG or IPT domain (Ig domain shared by Plexins and Transcription factors) found in plexins.


Pssm-ID: 465588  Cd Length: 89  Bit Score: 105.04  E-value: 1.43e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   541 PANISREETREVFLSVPDLPPLwpGESYSCHFGEH-QSPALLTGSGVMCPSPDPSEAPVLPRGADYVSVSVELRFGA--V 617
Cdd:pfam17960    2 PDNISRTTATQLTLTVPNLPAL--SEGYSCVFGDLtESPATVHDNGVKCATPPPSQLPPIPTGQDHVTVKLSLRSSEtgV 79

                           90
                   ....*....|
gi 194272180   618 VIAKTSLSFY 627
Cdd:pfam17960   80 DFASTNFTFY 89
Sema_MET_like cd11248
The Sema domain, a protein interacting module, of MET and RON receptor tyrosine kinases; This ...
 32-479 1.27e-23

The Sema domain, a protein interacting module, of MET and RON receptor tyrosine kinases; This family includes MET and RON receptor tyrosine kinases. MET is encoded by the c-met protooncogene. MET is the receptor for hepatocyte growth factor/scatter factor (HGF/SF). HGF/SF and MET regulates multiple cellular events and are essential for the development of several tissues and organs, including the placenta, liver, and several groups of skeletal muscles. RON receptor tyrosine kinase is a Macrophage-stimulating protein (MSP) receptor. Upon binding of MSP, RON is activated via autophosphorylation within its kinase catalytic domain, resulting in a variety of effects including proliferation, tubular morphogenesis, angiogenesis, cellular motility and invasiveness. By interacting with downstream signaling molecules, it regulates macrophage migration, phagocytosis, and nitric oxide production. MET and RON receptors have been implicated in cancer development and migration. They are composed of alpha-beta heterodimers. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The Sema domain is necessary for receptor dimerization and activation.


Pssm-ID: 200509 [Multi-domain]  Cd Length: 467  Bit Score: 106.74  E-value: 1.27e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   32 GTYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLdSRDCLPPvmPDECPQAQP---TNNPNQLLLVSPG-- 106
Cdd:cd11248     7 DTPIQNIVLNEGSTEVYVAAQNVIYALNPDLQKVWEYKTGPVG-SPDCQTC--QDCSSGADPgvpKDTDNMVLVLETYyd 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  107 -ALVVCGSVHQGVCEQRRL------GQLEQLLLRPER---PGDTQYVAAndPAVSTVGLVAQGLAgePLLFVGRGYTSRg 176
Cdd:cd11248    84 dYLYSCGSTQNGVCYRHVLedgadiQSEVHCLFSKKNnspSYCPDCVAS--PLGTKVTNVESGRT--IYFFVANSVNSS- 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  177 VGGGIPPITTRALWPPDPQAAFsYEETAKLAV--GRLSEYSHHFVSAFARGASAYFLFLRRD-LQAQSRAFRAYVSRVCL 253
Cdd:cd11248   159 LAGSFPPHSISVRRLKEDGFGF-LSDQSYLDVlpSLRDSYPIKYVYSFHSGPFVYFLTVQREsLTKPSSAFHTRLVRLCS 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  254 RDQHYYSYVELPLAC-------EGGR-----YGLIQAAAVATS-REVA-------HGEVLFAAFSSAAPPTVGRPPSAAa 313
Cdd:cd11248   238 SDSEIWRYREMPLECiftpkrrRRSTeedvvYNVLQAAHVSKVgADLAdelgaseGDDILFGVFARSKPDSGEPMPNSA- 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  314 gasgasaLCAFPLDEVDRLANRTRDACYTRegraedGTEVAYieydvNSDCAQLPVDTL--DAYPCGS--DHTPSPMAS- 388
Cdd:cd11248   317 -------LCAFPIKYVNDAIEKGVEKCCTS------GLEHFS-----GSLCHFQPCPTCpgESSSCEAtcKEYRTEVTKp 378

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  389 --RVPL---EATPILewpgiqLTAVAVTMEDGHTIAFLGDSQGQLHRVYLGPgSDGHPYSTQSIqQGSAVSRDLTFDGTF 463
Cdd:cd11248   379 yqRVDLfngQMSNVL------LTSILVTTIGNHTVAHLGTSDGRVLQVVLSR-SGPIPHVNFSL-DSQPVSREVAVLSSN 450

                         490
                  ....*....|....*.
gi 194272180  464 EHLYVMTQSTLLKVPV 479
Cdd:cd11248   451 GSLLFVTGDKITKVPL 466
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1162-1249 8.60e-19

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 82.89  E-value: 8.60e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1162 PKVHSIFPARGPRAGGTRLTLNGSKLLTGRlEDIRVVVGDQPCHLLPeQQSEQLRCETSPRPTPATLPVAVWFG---ATE 1238
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGS-PRVRVTVGGVPCKVLN-VSSTEIVCRTPAAATPGEGPVEVTVDganVSA 78

                          90
                  ....*....|.
gi 194272180 1239 RRLQRGQFKYT 1249
Cdd:cd00603    79 RVLSNTTFTYV 89
Sema pfam01403
Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and ...
 276-460 2.18e-17

Sema domain; The Sema domain occurs in semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor and Swiss:P51805


Pssm-ID: 460197 [Multi-domain]  Cd Length: 180  Bit Score: 81.93  E-value: 2.18e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   276 IQAAAVAT-SREVAHGEVLFAAFSSAAPPTVGRppsaaagasgaSALCAFPLDEVDRLANRtRDACYTREGRAEDGTEVA 354
Cdd:pfam01403    1 LQDVFVLKpGAGDALDTVLYGVFTTQWSNSIGG-----------SAVCAFSLSDINAVFEG-PFKEQEKSDSKWLPYTGK 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   355 yIEYDVNSDCAQLPV--DTLDAYPCGSDHTPSPMASRVPLEATPILEWPGIQLTAVAVTM---EDG-HTIAFLGDSQGQL 428
Cdd:pfam01403   69 -VPYPRPGTCINDPLrlDLPDSVLNFVKDHPLMDEAVQPVGGRPLLVRTGVRLTSIAVDRvqaLDGnYTVLFLGTDDGRL 147

                          170       180       190
                   ....*....|....*....|....*....|...
gi 194272180   429 HRVYLGPGSDGHPYSTQSI-QQGSAVSRDLTFD 460
Cdd:pfam01403  148 HKVVLVGSEESHIIEEIQVfPEPQPVLNLLLSS 180
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1070-1161 1.32e-16

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 76.72  E-value: 1.32e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1070 PLIHSVEPLTGPVDGGTRVTIRGSNLGQHVQDVlgMVTVAGVPCAVdaqEYEVSSSLVCITGASGEEVAGATAVEVPGRG 1149
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRV--RVTVGGVPCKV---LNVSSTEIVCRTPAAATPGEGPVEVTVDGAN 75

                          90
                  ....*....|....*
gi 194272180 1150 ---RGVSEHDFAYQD 1161
Cdd:cd00603    76 vsaRVLSNTTFTYVE 90
IPT smart00429
ig-like, plexins, transcription factors;
1161-1249 3.31e-16

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 75.53  E-value: 3.31e-16
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   1161 DPKVHSIFPARGPRAGGTRLTLNGSKLLTGRLEDIRVVVGDQPCHLLPEQQSeQLRCETSPRPT-PATLPV-AVWFGATE 1238
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGEAPCTFSPSSST-AIVCKTPPYHNiPGSVPVrTVGLRNGG 79

                            90
                    ....*....|.
gi 194272180   1239 RRLQRGQFKYT 1249
Cdd:smart00429   80 VPSSPQPFTYV 90
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 481-527 1.12e-14

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 70.04  E-value: 1.12e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 194272180   481 SCAQHLDCASCLAHRDPYCGWCVLLGRCSRRSECSrGQGPEQWLWSF 527
Cdd:pfam01437    1 RCSQYTSCSSCLAARDPYCGWCSSEGRCVRRSACG-APEGNCEEWEQ 46
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1162-1249 3.26e-14

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 69.80  E-value: 3.26e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1162 PKVHSIFPARGPRAGGTRLTLNGSKLLTGRleDIRVVV-GDQPCHLLPeQQSEQLRCETSPRPTPATLPVAVWF--GATE 1238
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGS--NLRVTFgGGVPCSVLS-VSSTAIVCTTPPYANPGPGPVEVTVdrGNGG 77

                          90
                  ....*....|.
gi 194272180 1239 RRLQRGQFKYT 1249
Cdd:cd00102    78 ITSSPLTFTYV 88
IPT smart00429
ig-like, plexins, transcription factors;
1070-1159 7.44e-14

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 68.99  E-value: 7.44e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   1070 PLIHSVEPLTGPVDGGTRVTIRGSNLGQhVQDVLGMVTVAGVPCAVDAQEyevSSSLVCITGASGEEVAGATAVEVPGRG 1149
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKS-ISVVFVEVGVGEAPCTFSPSS---STAIVCKTPPYHNIPGSVPVRTVGLRN 77

                            90
                    ....*....|..
gi 194272180   1150 RGV--SEHDFAY 1159
Cdd:smart00429   78 GGVpsSPQPFTY 89
RasGAP cd04519
Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is ...
 1916-2058 2.13e-13

Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin, among others. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP exhibit no similarity at their amino acid sequence level. RasGTPases function as molecular switches in a large number of signaling pathways. They are in the on state when bound to GTP, and in the off state when bound to GDP. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213328  Cd Length: 256  Bit Score: 72.52  E-value: 2.13e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1916 EIYLTRLLSMKGTLQKFVDDLFQVILSTSRPVPLAVKYFFDLLDEQAQQHGISDQDTIHIWKTNSLPLRFWINIIKNPQ- 1994
Cdd:cd04519   115 LPVGEDLEENLENLLELVNKLVDRILSSLDRLPPELRYVFKILREFLAERFPEEPDEAYQAVSGFLFLRFICPAIVSPEl 194

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194272180 1995 -FVFDVQTSDNMDAVLLVIAQTFMDACTLADH--KLGRDSPINkllyaRDIPRYKRMVERYYADIRQ 2058
Cdd:cd04519   195 fGLVPDEPSEQARRNLTLISKVLQSLANGVEFgdKEPFMKPLN-----DFIKSNKPKLKQFLDELSS 256
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1070-1161 6.75e-13

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 66.33  E-value: 6.75e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1070 PLIHSVEPLTGPVDGGTRVTIRGSNLGQHVQdvlGMVTV-AGVPCAVdaqEYEVSSSLVCITGASGEEVAGATAVEV--P 1146
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGSN---LRVTFgGGVPCSV---LSVSSTAIVCTTPPYANPGPGPVEVTVdrG 74

                          90
                  ....*....|....*
gi 194272180 1147 GRGRGVSEHDFAYQD 1161
Cdd:cd00102    75 NGGITSSPLTFTYVP 89
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1252-1375 6.97e-13

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 66.32  E-value: 6.97e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1252 PNITSAGPTKSFLSGGREICVRGQNLDVVQtPRIRVTVVSRmlqpsqglgrrrrvvpetacslgpscssqqfeePCHVN- 1330
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGS-PRVRVTVGGV---------------------------------PCKVLn 46

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 194272180 1331 -SSQLITCRTPALPGLPEDPwvrVEFILDNLVFDFATLNPTPFSYE 1375
Cdd:cd00603    47 vSSTEIVCRTPAAATPGEGP---VEVTVDGANVSARVLSNTTFTYV 89
Sema_MET cd11278
The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor ...
 45-338 2.56e-12

The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR); MET is encoded by the c-met protooncogene. MET is a receptor tyrosine kinase that binds its ligand, hepatocyte growth factor/scatter factor (HGF/SF). HGF/SF and MET are essential for the development of several tissues and organs, including the placenta, liver, and several groups of skeletal muscles. It also plays a major role in the abnormal migration of cancer cells as a result of overexpression or MET mutations. MET is composed of an alpha-beta heterodimer. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The cytoplasmic C-terminal region acts as a docking site for multiple protein substrates, including Grb2, Gab1, STAT3, Shc, SHIP-1 and Src. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. The Sema domain of Met is necessary for receptor dimerization and activation.


Pssm-ID: 200539 [Multi-domain]  Cd Length: 492  Bit Score: 71.82  E-value: 2.56e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   45 GTLYLGATNFLFQLSPGLQLEATVSTGPVLDSRDCLPPvmpDEC-PQAQPTN-----NPNQLLLVSP---GALVVCGSVH 115
Cdd:cd11278    36 HHIYVGAVNKIYVLNEDLQKVSEYKTGPVLEHPDCFPC---QDCsDKANLSNgvwkdNVNMALFVETyydDQLISCGSVN 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  116 QGVCeQRRLgqleqllLRPERPGDTQ------YVA--------ANDPAVSTVGlvAQGLAGEPLLFVGRGYTSRGVGGGI 181
Cdd:cd11278   113 RGTC-QRHV-------FPHDHPADIQsevhciYSPqieeepdqCPDCVVSTLG--SKVLVTVKDRFVNFFVGNTINSSYF 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  182 PP-----ITTRALwpPDPQAAFSYEeTAKLAVGRLSE----YSHHFVSAFARGASAYFLFLRRDlQAQSRAFRAYVSRVC 252
Cdd:cd11278   183 PDhplhsISVRRL--KETQDGFEFL-TDQSYIDVLPEfrdsYPIKYVHAFESNNFVYFLTVQRE-SLDSQTFHTRIIRFC 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  253 LRDQHYYSYVELPLAC-----------EGGRYGLIQAAAV-----ATSREVAHG---EVLFAAFSSAAPPTvgrppsaaA 313
Cdd:cd11278   259 SIDSELRSYMEMPLECiftekrrkrstKKEVFNILQAAYVskpgaQLAREMGASlndDILFGVFAQSKPDS--------A 330

                         330       340
                  ....*....|....*....|....*
gi 194272180  314 GASGASALCAFPLDEVDRLANRTRD 338
Cdd:cd11278   331 EPMNRSAVCAVSIKTINEFFNKIVD 355
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
482-520 3.55e-12

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 62.56  E-value: 3.55e-12
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 194272180    482 CAQHLDCASCLAHRDPYCGWCVLLGRCSRRSECSRGQGP 520
Cdd:smart00423    2 CSKYTSCSECLLARDPYCAWCSSQGRCTSGERCDSRRQN 40
IPT smart00429
ig-like, plexins, transcription factors;
1251-1374 1.19e-11

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 62.82  E-value: 1.19e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   1251 DPNITSAGPTKSFLSGGREICVRGQNLDVVQTPRIRVTVVsrmlqpsqglgrrrrvvpETACSLGPSCSSQqfeepchvn 1330
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVG------------------EAPCTFSPSSSTA--------- 53

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*
gi 194272180   1331 ssqlITCRTPALPGLPEDPWVR-VEFILDNLVFDfatlnPTPFSY 1374
Cdd:smart00429   54 ----IVCKTPPYHNIPGSVPVRtVGLRNGGVPSS-----PQPFTY 89
Sema_RON cd11279
The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase; RON receptor ...
 32-479 1.34e-11

The Sema domain, a protein interacting module, of RON Receptor Tyrosine Kinase; RON receptor tyrosine kinase is a Macrophage-stimulating protein (MSP) receptor. Upon binding of MSP, RON is activated via autophosphorylation within its kinase catalytic domain, resulting in a wide range of effects, including proliferation, tubular morphogenesis, angiogenesis, cellular motility and invasiveness. By interacting with downstream signaling molecules, it regulates macrophage migration, phagocytosis, and nitric oxide production. RON has been implicated in cancers of the breast, colon, pancreas and ovaries because both splice variants and receptor overexpression have been identified in these tumors. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as ligand recognition and binding model. RON is composed of an alpha-beta heterodimer. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a Sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic tyrosine kinase domain. The Sema domain of RON may be necessary for receptor dimerization and activation.


Pssm-ID: 200540 [Multi-domain]  Cd Length: 493  Bit Score: 69.42  E-value: 1.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   32 GTYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVlDSRDClppVMPDECPQAQPTNNP----NQLLLVSPG- 106
Cdd:cd11279    26 GSPIQNIVSYEDASAVFVATRNHLHVLNPELKLLQNLVTGPT-GSPGC---QICALCPPGPPGPSPedtdNKVLVLDPEe 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  107 -ALVVCGSVHQGVCeqrRLGQLEQLLlRPERPGDTQ--YVAANDPAVSTVGLVAQGLaGEPLLFVGRGYTS--------- 174
Cdd:cd11279   102 pWLYSCGSSLHGRC---FLHELESRG-SAVHIASTAclFSANANKPSDCPDCVASPL-GTRVTVVEQSHTSyfyvastln 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  175 RGVGGGIPP--ITTRALWPPDPQAAFSYEETAKLAVGRLSeYSHHFVSAFARGASAYFLFLRRDlQAQSRAFRAYVSRVC 252
Cdd:cd11279   177 SSVAASYSPrsVSIRRLKSDQDGFAPGFHSLTVLPKYLDS-YPIHYVHSFTSGDFVYFLTVQPE-SPDSSAYHTRLVRLS 254

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  253 LRDQHYYSYVELPLAC--------------EGGRYGLIQAAAVAT-----SRE--VAHGE-VLFAAFSSAAPPTVGRPPS 310
Cdd:cd11279   255 AKEPELRDYRELVLDCrfepkrrrrrrpaeREVPYNVLQAAHAAPvgsklAVElgISEGQeVLFGVFAESQPGSPVPQKN 334

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  311 AAagasgasaLCAFPLDEVDRLANRTRDACYtrEGRAEDGTEVAYIEYDVNSDCAQLPVDTLDAYPCGSDHTP---SPMA 387
Cdd:cd11279   335 SA--------VCAFPISLLNEAIDEGMEKCC--SSSNSDRLFRGLDFFQPQSYCPHPPNLSAAVSNTSCWNFPtlvSTSS 404

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  388 SRVPLEATPIlewPGIQLTAVAVTMEDGHTIAFLGDSQGQLHRVYLGPGSDGHPY-STQSIQQGSAVSRDLTFDGtfEHL 466
Cdd:cd11279   405 FRVDLFNGHL---SGVLLTSIYVTVLDNVTVAHLGTSDGRILQVVLQRSLNYLLYvSNFSLGDGQPVQRDVSRLG--DSL 479

                         490
                  ....*....|...
gi 194272180  467 YVMTQSTLLKVPV 479
Cdd:cd11279   480 LFASGNQVFKVNI 492
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1162-1232 3.04e-11

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 61.56  E-value: 3.04e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194272180 1162 PKVHSIFPARGPRAGGTRLTLNGSKLltG-RLEDIR--VVVGDQPCHLLPE--QQSEQLRCETSPRPTPA-TLPVAV 1232
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSNL--GlRKNDVRhgVRVGGVPCNPEPPeySSSEKIVCTTGPAGNPVfNGPVEV 75
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1070-1159 7.70e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 60.15  E-value: 7.70e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  1070 PLIHSVEPLTGPVDGGTRVTIRGSNLGQHVQDVlgMVTVAGVPCAVDAQEyevSSSLVCITGASGEEVAGATaVEVPGRG 1149
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDL--KVTIGGTPCTVISVS---STTIVCTTPPGTSGLVNVS-VTVGGGG 74

                           90
                   ....*....|
gi 194272180  1150 RGVSEHDFAY 1159
Cdd:pfam01833   75 ISSSPLTFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1162-1248 1.42e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 59.38  E-value: 1.42e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  1162 PKVHSIFPARGPRAGGTRLTLNGSKLLTGRlEDIRVVVGDQPChLLPEQQSEQLRCETSPRpTPATLPVAVWFGATERRL 1241
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDS-SDLKVTIGGTPC-TVISVSSTTIVCTTPPG-TSGLVNVSVTVGGGGISS 77


                   ....*..
gi 194272180  1242 QRGQFKY 1248
Cdd:pfam01833   78 SPLTFTY 84
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1252-1374 1.93e-09

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 56.32  E-value: 1.93e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1252 PNITSAGPTKSFLSGGREICVRGQNLDVVQTPRIRVTVvsrmlqpsqglgrrrrvvpETACSLGPSCSSQqfeepchvns 1331
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFGG-------------------GVPCSVLSVSSTA---------- 51

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 194272180 1332 sqlITCRTPALPGLPEdpwVRVEFILDNLVfDFATLNPTPFSY 1374
Cdd:cd00102    52 ---IVCTTPPYANPGP---GPVEVTVDRGN-GGITSSPLTFTY 87
PHA03247 PHA03247
large tegument protein UL36; Provisional
 681-839 3.96e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.18  E-value: 3.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  681 SPDPPARGGPsPSPPTAPKALATPAPDTLPVEPGAPSTATASDISPGASPSLLSPwgpwagsgsiSSPGSTGSPLHEEPS 760
Cdd:PHA03247 2732 SPALPAAPAP-PAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTR----------PAVASLSESRESLPS 2800

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  761 PPSPQNGPGTAVPAPTDFRPSATPEDLLASPLSPSEVAAVPPADPGPEALHP------------TVPLDLPPATVPATTF 828
Cdd:PHA03247 2801 PWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLggsvapggdvrrRPPSRSPAAKPAAPAR 2880

                         170
                  ....*....|.
gi 194272180  829 PGAMGSVKPAL 839
Cdd:PHA03247 2881 PPVRRLARPAV 2891
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 661-880 7.93e-08

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 57.69  E-value: 7.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  661 THKASCDAGPMVASHQ---SPLVSPDPPARGGPSPSPPTAPKALATPAPDTLPVEPGAPSTATASD-ISPGASPSLLSPW 736
Cdd:PRK07764  581 DWQVEAVVGPAPGAAGgegPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGvAAPEHHPKHVAVP 660

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  737 GPWAGSGSISSPGSTGSPLHEEPSPPS-PQNGPGTAVPAPTDFRPSATP-----EDLLASPLSPSEVAAVPPAD-----P 805
Cdd:PRK07764  661 DASDGGDGWPAKAGGAAPAAPPPAPAPaAPAAPAGAAPAQPAPAPAATPpagqaDDPAAQPPQAAQGASAPSPAaddpvP 740

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194272180  806 GPEALHPTVPLDLPPATVPATTFPGAMGSVKPALDWLTREGGELPEADEWTGGDAPAFSTSTLLSGDGDSAELEG 880
Cdd:PRK07764  741 LPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDRRDAEEVAMELLEEELGA 815
PHA03247 PHA03247
large tegument protein UL36; Provisional
 663-853 8.57e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 58.03  E-value: 8.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  663 KASCDAGPMVAShqSPLVSPDPPARGGPSPS------PPTAPKALATPAPDTLPVEPGAPSTATASDISPGASPSLLSPW 736
Cdd:PHA03247 2666 RARRLGRAAQAS--SPPQRPRRRAARPTVGSltsladPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPA 2743

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  737 GPWAGSGSISSPGSTGSPLHEEPSPPSPQNGPGTAVPAPTDFRPSATPEDLLASPLSPSEVAAVPPADPGPEALHPTVPL 816
Cdd:PHA03247 2744 VPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAS 2823

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 194272180  817 DLPPATVPATTFPGAMGSVK-PALDWLTREGGELPEAD 853
Cdd:PHA03247 2824 PAGPLPPPTSAQPTAPPPPPgPPPPSLPLGGSVAPGGD 2861
PHA03247 PHA03247
large tegument protein UL36; Provisional
 656-884 1.25e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.64  E-value: 1.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  656 WQHLCTHKASCDAGpmvashqsplvspDPPARGGPSPSPPTAPKALATPAPDTLPVEPGAPSTATASDISP-GASPSL-L 733
Cdd:PHA03247 2536 WIRGLEELASDDAG-------------DPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPqSARPRApV 2602

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  734 SPWGPWAGSGSISSPGSTGSPLHEEPSPPSP---QNGPGTAVPAPTDFRPSATPEDLLASP------LSPSEVAAVPPAD 804
Cdd:PHA03247 2603 DDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPaanEPDPHPPPTVPPPERPRDDPAPGRVSRprrarrLGRAAQASSPPQR 2682

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  805 PGPEALHPTV---------------PLDLPPATVPAT---TFPGAMGSVKPALDwLTREGGELPEADEWTGGDAPAFSTS 866
Cdd:PHA03247 2683 PRRRAARPTVgsltsladpppppptPEPAPHALVSATplpPGPAAARQASPALP-AAPAPPAVPAGPATPGGPARPARPP 2761

                         250
                  ....*....|....*...
gi 194272180  867 TlLSGDGDSAELEGPPAP 884
Cdd:PHA03247 2762 T-TAGPPAPAPPAAPAAG 2778
PHA03378 PHA03378
EBNA-3B; Provisional
 652-838 1.33e-07

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 57.00  E-value: 1.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  652 NWCVWQHLCTHKASCDAGPMVASHQSPLVSPDPPARGGPSPSPPTAPKALATPAPDTLPVEP--GAPSTATASDISPGAS 729
Cdd:PHA03378  665 TWTQIGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPpaAAPGRARPPAAAPGRA 744

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  730 PsllSPWGPWAGSGSISSPGSTGSPLHEEPSPPSPQNGPgTAVPAPTDfRPSATPEDLLASPLSPSEVAAVPPADPGPEA 809
Cdd:PHA03378  745 R---PPAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPP-QAPPAPQQ-RPRGAPTPQPPPQAGPTSMQLMPRAAPGQQG 819

                         170       180       190
                  ....*....|....*....|....*....|...
gi 194272180  810 LHPTVPLDLPPATV----PATTFPGAMGSVKPA 838
Cdd:PHA03378  820 PTKQILRQLLTGGVkrgrPSLKKPAALERQAAA 852
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
681-883 1.65e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 56.42  E-value: 1.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  681 SPDPPARGGP--SPSPPTAPKALATPAPDTLPVEPGAPSTATASDISPGASPSLLSPwGPWAGSGSISSPGSTGSPLHEE 758
Cdd:PRK12323  372 AGPATAAAAPvaQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSP-APEALAAARQASARGPGGAPAP 450

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  759 PSPPSPqngpgtaVPAPTDFRPSATPEDLLASPLSPSEVAAvPPADPGPEALHPTVPLDLPPATVPATTFPGAMGSVKPA 838
Cdd:PRK12323  451 APAPAA-------APAAAARPAAAGPRPVAAAAAAAPARAA-PAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWV 522

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 194272180  839 LDWLTREGGELPEADEWTGGDAPAFSTSTLLSGDGDSAELEGPPA 883
Cdd:PRK12323  523 AESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPR 567
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 661-912 2.09e-07

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 56.72  E-value: 2.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  661 THKASCDAGPMVASHQSPLVSPDPPARGGPSPSPPT---APKALATPAPDTLPVEPGAPSTATASDISPGASPSLLSPWG 737
Cdd:PHA03307   54 TVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTwslSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPD 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  738 PWAgsgsisspgstgsPLHEEPSPPSPQNGPGTAVPAPTDFRPSATPEDLLASPLSPSEVAAVPPADPGPEALHPTVPLD 817
Cdd:PHA03307  134 LSE-------------MLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPSTPPA 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  818 LPPATVPATTFPGAMGSVKPAldwltreggELPEADEWTGGDAPAFSTSTLLSGDGDSAELEGPPAPLILPSSLDYQYDT 897
Cdd:PHA03307  201 AASPRPPRRSSPISASASSPA---------PAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWE 271

                         250
                  ....*....|....*
gi 194272180  898 PGLWELEEATLGASS 912
Cdd:PHA03307  272 ASGWNGPSSRPGPAS 286
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 670-837 4.66e-07

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 55.16  E-value: 4.66e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   670 PMVASHQSPLVSPDPPARGGPSPSPPTAPkalaTPAPDTLPVEPGAPSTATASDISPGASPSLLSPWGPWAGSGSISSPG 749
Cdd:pfam03154  171 PPVLQAQSGAASPPSPPPPGTTQAATAGP----TPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPH 246

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   750 STGSPLHEEPSPP--SPQ-------NGPGTAVPAPTDFRPSATPEDLLAS-------------PLSPSEVAAV------- 800
Cdd:pfam03154  247 PPLQPMTQPPPPSqvSPQplpqpslHGQMPPMPHSLQTGPSHMQHPVPPQpfpltpqssqsqvPPGPSPAAPGqsqqrih 326

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 194272180   801 -PPADPGPEALHPTVPLDLPPAtvpattfPGAMGSVKP 837
Cdd:pfam03154  327 tPPSQSQLQSQQPPREQPLPPA-------PLSMPHIKP 357
PHA03247 PHA03247
large tegument protein UL36; Provisional
 667-820 5.52e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 55.33  E-value: 5.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  667 DAGPM-VASHQSPLVSPDP-PARGGPSPSPPTAPKALATPAPDTLPVEPGAPSTATASDISPGASPSLLSPWGPWAGSGS 744
Cdd:PHA03247 2751 PGGPArPARPPTTAGPPAPaPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPP 2830

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194272180  745 ISSPGSTGSPLHEEPSPPSpqNGPGTAVPAPTDFRPSATPEDLLASPLSPSEvaavPPAD--PGPEALHPTVPLDLPP 820
Cdd:PHA03247 2831 PTSAQPTAPPPPPGPPPPS--LPLGGSVAPGGDVRRRPPSRSPAAKPAAPAR----PPVRrlARPAVSRSTESFALPP 2902
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
667-852 6.52e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 54.50  E-value: 6.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  667 DAGPmvASHQSPLVSPDPPARGGPSPspptapkalATPAPDTLPVEPGAPSTATASDISPGASPSLLSPwGPWAGSGSIS 746
Cdd:PRK12323  371 GAGP--ATAAAAPVAQPAPAAAAPAA---------AAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSP-APEALAAARQ 438

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  747 SPGSTGSPLHEEPSPPSPQNGPGTAVPAPtdfrPSATPEDLLASPLSPSEVAAVP-PADPGP---EALHPTVPLDLPPAT 822
Cdd:PRK12323  439 ASARGPGGAPAPAPAPAAAPAAAARPAAA----GPRPVAAAAAAAPARAAPAAAPaPADDDPppwEELPPEFASPAPAQP 514

                         170       180       190
                  ....*....|....*....|....*....|
gi 194272180  823 VPATTFPGAMGSVKPALDWLTREGGELPEA 852
Cdd:PRK12323  515 DAAPAGWVAESIPDPATADPDDAFETLAPA 544
PRK08691 PRK08691
DNA polymerase III subunits gamma and tau; Validated
 664-934 7.40e-07

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236333 [Multi-domain]  Cd Length: 709  Bit Score: 54.33  E-value: 7.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  664 ASCDAGPMVASHQSPLVSPDPPARGGPSPSPPTAPKALATPAPDTLPVEPGAPSTA-TASDISPGASPSLlspwGPWAGS 742
Cdd:PRK08691  364 ASCDANAVIENTELQSPSAQTAEKETAAKKPQPRPEAETAQTPVQTASAAAMPSEGkTAGPVSNQENNDV----PPWEDA 439

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  743 GSISspgstgsplhEEPSPPSP------QNGPGTAVPAPTDFRPSATPEDLLASPLS--PSEVAAVppADPGPEALHPTV 814
Cdd:PRK08691  440 PDEA----------QTAAGTAQtsaksiQTASEAETPPENQVSKNKAADNETDAPLSevPSENPIQ--ATPNDEAVETET 507

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  815 PLDLPPAtvpattfPGAMGSVKPALDWLTREGGELPEADeWTGGdAPAFSTSTLLSGDGDSAELEGPPAPlILPSSLDYQ 894
Cdd:PRK08691  508 FAHEAPA-------EPFYGYGFPDNDCPPEDGAEIPPPD-WEHA-APADTAGGGADEEAEAGGIGGNNTP-SAPPPEFST 577

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 194272180  895 YDTPGLWELEEATLGASSCPCVESV-----QGSTLMPVHVEREIR 934
Cdd:PRK08691  578 ENWAAIVRHFARKLGAAQMPAQHSAwteyhPDTGLMVLAMTAEAR 622
PHA03247 PHA03247
large tegument protein UL36; Provisional
 670-844 1.19e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 1.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  670 PMVASHQSPLvSPDPPARGGPSPSPPTAPKALATPAPDTLPVEPGAPSTATASDISPGASPSLLSPWGPwAGSGSISSPG 749
Cdd:PHA03247 2712 PHALVSATPL-PPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGP-PRRLTRPAVA 2789

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  750 STGSPLHEEPSPPSPQNGPGTAVPAPTDFRPSATPedllASPLSPsevaavppadpgPEALHPTVPldlPPATVPATTFP 829
Cdd:PHA03247 2790 SLSESRESLPSPWDPADPPAAVLAPAAALPPAASP----AGPLPP------------PTSAQPTAP---PPPPGPPPPSL 2850

                         170
                  ....*....|....*
gi 194272180  830 GAMGSVKPALDWLTR 844
Cdd:PHA03247 2851 PLGGSVAPGGDVRRR 2865
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
664-830 1.41e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 53.73  E-value: 1.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  664 ASCDAGPMVASHQSPLVSPDPPARGGPSPSPPTAPKALATPAPDTLPVEPGAPSTATASDISPGASPSLLSPWGPWAGSG 743
Cdd:PRK12323  398 APAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAA 477

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  744 SISSPGS---------TGSPLHEEPSPPSPQNGPGTAVPAPTDFRPSATPEDLLASPLSPSEVAAV-PPADPGPEALHPT 813
Cdd:PRK12323  478 AAPARAApaaapapadDDPPPWEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPaPAAAPAPRAAAAT 557

                         170
                  ....*....|....*..
gi 194272180  814 VPldLPPATVPATTFPG 830
Cdd:PRK12323  558 EP--VVAPRPPRASASG 572
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
641-677 4.48e-06

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 45.61  E-value: 4.48e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 194272180    641 CQACVSSRWG-CNWCVWQHLCTHKASCDAGPMVASHQS 677
Cdd:smart00423    8 CSECLLARDPyCAWCSSQGRCTSGERCDSRRQNWLSGG 45
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
664-862 4.78e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 51.77  E-value: 4.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  664 ASCDAGPMVASHQSPLVSPDPPARGGPSPSPPTAPKALATPAPDTLPVEPGAPSTATASdiSPGASPSLLSPWGPWAGSG 743
Cdd:PRK07003  392 GASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVP--AKANARASADSRCDERDAQ 469

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  744 SISSPGSTGSPLHEEPSPPSPQNGPGTAVPAPTDFRPSATPEDLLASPLsPSEVAavPPADPGPEALHPTvpldlPPATV 823
Cdd:PRK07003  470 PPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASR-EDAPA--AAAPPAPEARPPT-----PAAAA 541

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 194272180  824 PATTFPGAMGsvkpALDWLtREGGELPEADEWTGGDAPA 862
Cdd:PRK07003  542 PAARAGGAAA----ALDVL-RNAGMRVSSDRGARAAAAA 575
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 675-824 6.45e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 51.69  E-value: 6.45e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   675 HQSPLVSPDPPARGGPSPSPP--TAPKALATPA-------------------PDTLPVEP-GAPSTATASDISPGASPSL 732
Cdd:pfam03154  238 HPQRLPSPHPPLQPMTQPPPPsqVSPQPLPQPSlhgqmppmphslqtgpshmQHPVPPQPfPLTPQSSQSQVPPGPSPAA 317

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   733 LSPWGPWAGSGSISSPGSTGSPLHEEPSPPSPQNGPGTAVPAPTDFRPSATPEdllaSPLSPSEVAAVPPAD-----PGP 807
Cdd:pfam03154  318 PGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQ----SHKHPPHLSGPSPFQmnsnlPPP 393

                          170
                   ....*....|....*....
gi 194272180   808 EALHP--TVPLDLPPATVP 824
Cdd:pfam03154  394 PALKPlsSLSTHHPPSAHP 412
Sema_5B cd11264
The Sema domain, a protein interacting module, of semaphorin 5B (Sema5B); Sema5B is expressed ...
 37-255 6.82e-06

The Sema domain, a protein interacting module, of semaphorin 5B (Sema5B); Sema5B is expressed in regions of the basal telencephalon in rat. Sema5B is an inhibitory cue for corticofugal axons and acts as a source of repulsion for the appropriate guidance of cortical axons away from structures such as the ventricular zone as they navigate toward and within subcortical regions. In addition to its role as a guidance cue, Sema5B regulates the development and maintenance of synapse size and number in hippocampal neurons. In addition, the sema domain of Sema5B can be cleaved of the whole protein and exerts its function in regulation of synapse morphology. Sema5B belongs to the class 5 semaphorin family of proteins, which are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200525 [Multi-domain]  Cd Length: 437  Bit Score: 50.75  E-value: 6.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   37 HLARDPTSGTLYLGATNFLFQLS-PGLQLEATVSTGPVLDS-RDCLPP-VMPDECpqaqptNNPNQLLLVSPGALVVCGS 113
Cdd:cd11264    11 QLALDLNRNQLIVGARNYLFRLSlHNVSLIQATEWGSDEDTrRSCQSKgKTEEEC------QNYVRVLIVYGKKVFTCGT 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  114 -VHQGVCEQRRLGQLEQLLLRPERPGDTQYvaanDPA-VSTVGLVAQG--LAGEPLLFVGRGYTSRGVGGGIPPITT--- 186
Cdd:cd11264    85 nAFSPVCTSRQVGNLSKVIERINGVARCPY----DPRhNSTAVITSRGelYAATVIDFSGRDPAIYRSLGSVPPLRTaqy 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 194272180  187 RALWPPDPqaafsyeetaklavgrlseyshHFVSAFARGASAYFlFLRRDLQAQS--RAFRAYVSRVCLRD 255
Cdd:cd11264   161 NSKWLNEP----------------------NFIAAYDIGLFTYF-FFRENAVEHDcgKTVYSRVARVCKND 208
PHA03247 PHA03247
large tegument protein UL36; Provisional
 668-884 8.04e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.48  E-value: 8.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  668 AGPMVASHQSPLVSPDPPARGGPSPSPPTAPKALATPAPDTL-----PVEPGAPSTA---TASDISPGASPSLLSPWGPW 739
Cdd:PHA03247 2777 AGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALppaasPAGPLPPPTSaqpTAPPPPPGPPPPSLPLGGSV 2856

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  740 AGSGSISSPGSTGSPLheePSPPSPQNGPGTAVPAPTdfrPSATPEDLLASPLSPSEvaavPPADPGPEALHPTVPLDLP 819
Cdd:PHA03247 2857 APGGDVRRRPPSRSPA---AKPAAPARPPVRRLARPA---VSRSTESFALPPDQPER----PPQPQAPPPPQPQPQPPPP 2926

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194272180  820 PATVPATTFPGAMGS-VKPALDWLTREGGELPEADEWTGGDAPA--FSTSTLLSGDGDSAELEGPPAP 884
Cdd:PHA03247 2927 PQPQPPPPPPPRPQPpLAPTTDPAGAGEPSGAVPQPWLGALVPGrvAVPRFRVPQPAPSREAPASSTP 2994
PHA03247 PHA03247
large tegument protein UL36; Provisional
 673-889 1.61e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 1.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  673 ASHQSPLVSPDPPARGGPSPSPPTAPKALATPAPDTLPVEPGA----PSTAT--------ASDISpGASPSLLSPWGPwa 740
Cdd:PHA03247 2484 AEARFPFAAGAAPDPGGGGPPDPDAPPAPSRLAPAILPDEPVGepvhPRMLTwirgleelASDDA-GDPPPPLPPAAP-- 2560

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  741 gsgsisspgstgsPLHEEPSPPSPQNGPGTAVPAPT--DFRPSATPEDllASPLSPSEVAAVPPADPGPEALHPTVPLDL 818
Cdd:PHA03247 2561 -------------PAAPDRSVPPPRPAPRPSEPAVTsrARRPDAPPQS--ARPRAPVDDRGDPRGPAPPSPLPPDTHAPD 2625

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 194272180  819 PPATVPAttfpgAMGSVKPALDWLTREGGELPEADEWTGGDAPAFSTSTLLSGDGDSAELEGPPAPLILPS 889
Cdd:PHA03247 2626 PPPPSPS-----PAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPT 2691
PHA03247 PHA03247
large tegument protein UL36; Provisional
 673-891 1.91e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 1.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  673 ASHQSPLVSPDPPARGGPSPSPPTAPkALATPAPDTLPVEPGA--PSTATASDISPGAS--------PSLLSPWGPWAGS 742
Cdd:PHA03247 2620 DTHAPDPPPPSPSPAANEPDPHPPPT-VPPPERPRDDPAPGRVsrPRRARRLGRAAQASsppqrprrRAARPTVGSLTSL 2698

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  743 GSISSPGSTGSP-----LHEEPSPPSPQNGPGTAVPAPTDFRPSATPEDlLASPLSPSEVAAvPPADPGPEAlhPTVPLD 817
Cdd:PHA03247 2699 ADPPPPPPTPEPaphalVSATPLPPGPAAARQASPALPAAPAPPAVPAG-PATPGGPARPAR-PPTTAGPPA--PAPPAA 2774

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194272180  818 lPPATVPATTFPGAMGSVKPALDWLTREGGELPEADEWTGGDA---PAFSTSTLLSGDGDSAELEGPPAPLILPSSL 891
Cdd:PHA03247 2775 -PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAalpPAASPAGPLPPPTSAQPTAPPPPPGPPPPSL 2850
Sema_5 cd11241
The Sema domain, a protein interacting module, of semaphorin 5 (Sema5); Class 5 semaphorins ...
 32-255 1.95e-05

The Sema domain, a protein interacting module, of semaphorin 5 (Sema5); Class 5 semaphorins are transmembrane glycoproteins characterized by unique thrombospondin specific repeats in the extracellular region of the protein. There are three subfamilies in class 5 semaphorins, namely 5A, 5B and 5C. Sema5A and Sema5B function as guidance cues for optic and corticofugal nerve development, respectively. Sema5A-induced cell migration requires Met signaling. Sema5C is an early development gene and may play a role in odor-guided behavior. Sema5A is also implicated in cancer. In a screening model for metastasis, the Drosophila Sema5A ortholog, Dsema-5C, has been found to be required in tumorigenicity and metastasis. Sema5A is highly expressed in human pancreatic cancer cells and is associated with tumor growth, invasion and metastasis. Semaphorins are regulatory molecules involved in the development of the nervous system and in axonal guidance. They also play important roles in other biological processes, such as angiogenesis, immune regulation, respiration systems and cancer. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200502 [Multi-domain]  Cd Length: 438  Bit Score: 49.47  E-value: 1.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   32 GTYLQHLArDPTSGTLYLGATNFLFQLSpgLQ----LEATVSTGPVLDSRDC-LPPVMPDECpqaqptNNPNQLLLVSPG 106
Cdd:cd11241     7 SDFSRLVL-DPTHDQLIVGARNYLFRLR--LQslslLQAVPWNSDEDTKRQCqSKGKSVEEC------QNYVRVLLVVGK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  107 ALVVCGS-VHQGVCEQRRLGQLEQLLLRPERPGDTQYvaanDPAV-STVGLVAQG--LAGEPLLFVGRGYTSRGVGGGIP 182
Cdd:cd11241    78 NLFTCGTyAFSPVCTIRKLSNLTQILDTISGVARCPY----SPAHnSTALISASGelYAGTVYDFSGRDPAIYRSLGGKP 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194272180  183 PITTR---ALWPPDPQaafsyeetaklavgrlseyshhFVSAFARGASAYFLFLRRDLQAQSRAFRAY--VSRVCLRD 255
Cdd:cd11241   154 PLRTAqynSKWLNEPN----------------------FVGSYEIGNHTYFFFRENAVEHQDCGKTVYsrIARVCKND 209
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
681-838 1.97e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 49.85  E-value: 1.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  681 SPDPPARGGPSPSPPTAPKALATPAPDTLPV-----EPGAPSTATASDISPGASPSLLSPWGPWAGSGSISSPGSTGSPL 755
Cdd:PRK07003  372 VPARVAGAVPAPGARAAAAVGASAVPAVTAVtgaagAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPA 451

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  756 HEE-PSPPSPQNGPGTAVPaPTDFRPSATPEDlLASPLSPSEVAavPPADPGPEALHPTVPLDLPPATVPATTFPGAMGS 834
Cdd:PRK07003  452 KANaRASADSRCDERDAQP-PADSGSASAPAS-DAPPDAAFEPA--PRAAAPSAATPAAVPDARAPAAASREDAPAAAAP 527


                  ....
gi 194272180  835 VKPA 838
Cdd:PRK07003  528 PAPE 531
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 1021-1061 2.85e-05

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 43.47  E-value: 2.85e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 194272180  1021 DCSvGHGDCSRCQTAmPQYGCVWCEGERpRCVTREACGEAE 1061
Cdd:pfam01437    1 RCS-QYTSCSSCLAA-RDPYCGWCSSEG-RCVRRSACGAPE 38
PHA03247 PHA03247
large tegument protein UL36; Provisional
 676-895 2.86e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.55  E-value: 2.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  676 QSPLVSPDPPARGGPSPSPPTAPKALATPAPDTLPVEPGAPSTATASdiSPGASPSLLSPWgpwagsgsissPGSTGSPL 755
Cdd:PHA03247 2905 PERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAG--AGEPSGAVPQPW-----------LGALVPGR 2971

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  756 HEEPSPPSPQNGPGTAVPAPtdfrPSATPEDLLASPLS--PSEVAAVPPADPGPEALHPT--VPLDLPPATVPATTFPGA 831
Cdd:PHA03247 2972 VAVPRFRVPQPAPSREAPAS----STPPLTGHSLSRVSswASSLALHEETDPPPVSLKQTlwPPDDTEDSDADSLFDSDS 3047

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 194272180  832 MGSVKPALDwltreggelPEADEWTGGDAPAFSTSTLLSGDGDSAELEGPPAPLILPSSLDYQY 895
Cdd:PHA03247 3048 ERSDLEALD---------PLPPEPHDPFAHEPDPATPEAGARESPSSQFGPPPLSANAALSRRY 3102
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 684-830 5.22e-05

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 48.38  E-value: 5.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  684 PPArgGPSPSPPTAPKALATP-----APDTLPVEPGAPSTATASDISPGASPSLLS-PWGPWAGsgsisspgstgsplHE 757
Cdd:PLN03209  382 PPT--SPIPTPPSSSPASSKSvdavaKPAEPDVVPSPGSASNVPEVEPAQVEAKKTrPLSPYAR--------------YE 445

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 194272180  758 EPSPP-SPQNGPGTAVPAPTDFRPSATPEDLLASPLSPSEVAAVPPADPGPEALHPtVPLDLPPATVPATTFPG 830
Cdd:PLN03209  446 DLKPPtSPSPTAPTGVSPSVSSTSSVPAVPDTAPATAATDAAAPPPANMRPLSPYA-VYDDLKPPTSPSPAAPV 518
KLF9_13_N-like cd21975
Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like ...
 680-826 5.65e-05

Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF9, KLF13, KLF14, KLF16, and similar proteins.


Pssm-ID: 409240 [Multi-domain]  Cd Length: 163  Bit Score: 45.84  E-value: 5.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  680 VSPDPPARGGPSPSPPTAPKA-LATPAPDTLPVEPGAPSTATASdispGASPSLL--SPWGPWAGSGSISSPGSTGSPLH 756
Cdd:cd21975    21 VRPDPEGAGLAAGLDVRATREvAKGPGPPGPAWKPDGADSPGLV----TAAPHLLaaNVLAPLRGPSVEGSSLESGDADM 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  757 EEPSPPSPQngPGTAvpaptdfrPSATPEDLLASPLSPSEVAAVPPADPGPEALHPTVPLDLPPATVPAT 826
Cdd:cd21975    97 GSDSDVAPA--SGAA--------ASTSPESSSDAASSPSPLSLLHPGEAGLEPERPRPRVRRGVRRRGVT 156
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 682-807 5.77e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 48.44  E-value: 5.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  682 PDPPARGGPSPSPPTAPKALATPAPDTLPVEPGAPSTATASDISPGASPSllspwgpwagsGSISSPGSTGSPLHEEPSP 761
Cdd:PRK07764  393 APAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPP-----------SPAGNAPAGGAPSPPPAAA 461

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 194272180  762 PSPQNGPGTAVPAPTDFRPSATPEDLLASPLSPsEVAAVPPADPGP 807
Cdd:PRK07764  462 PSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAP-AAPAAPAAPAGA 506
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 666-884 6.03e-05

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 48.00  E-value: 6.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  666 CDAGPMVASHQSPLVSPDPPARGGPSPS-PPTAPKALATPAP-DTLPVEPGAPSTAtaSDISP----GASPSLLSPWGPW 739
Cdd:PLN03209  300 CKVVEVIAETTAPLTPMEELLAKIPSQRvPPKESDAADGPKPvPTKPVTPEAPSPP--IEEEPpqpkAVVPRPLSPYTAY 377

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  740 AGSgsisspgstgsplhEEPSPPSPqNGPGTAVPAPTDFRPSATPE--DLLASPLSPSEVAAVPPADPGPEALHPTVPL- 816
Cdd:PLN03209  378 EDL--------------KPPTSPIP-TPPSSSPASSKSVDAVAKPAepDVVPSPGSASNVPEVEPAQVEAKKTRPLSPYa 442

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 194272180  817 ---DLPPATVPATTFPGAMGSVKPALDWLTREGGELPeADEWTGGDAPAFSTSTLLSGDGDSAELEGPPAP 884
Cdd:PLN03209  443 ryeDLKPPTSPSPTAPTGVSPSVSSTSSVPAVPDTAP-ATAATDAAAPPPANMRPLSPYAVYDDLKPPTSP 512
PSI smart00423
domain found in Plexins, Semaphorins and Integrins;
1021-1068 6.61e-05

domain found in Plexins, Semaphorins and Integrins;


Pssm-ID: 214655 [Multi-domain]  Cd Length: 47  Bit Score: 42.15  E-value: 6.61e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 194272180   1021 DCSVgHGDCSRCQTAMPQYgCVWCEGERpRCVTREACGE--AEAVATQCP 1068
Cdd:smart00423    1 RCSK-YTSCSECLLARDPY-CAWCSSQG-RCTSGERCDSrrQNWLSGGCP 47
RasGAP cd04519
Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is ...
 1614-1724 1.16e-04

Ras GTPase Activating Domain; RasGAP functions as an enhancer of the hydrolysis of GTP that is bound to Ras-GTPases. Proteins having a RasGAP domain include p120GAP, IQGAP, Rab5-activating protein 6, and Neurofibromin, among others. Although the Rho (Ras homolog) GTPases are most closely related to members of the Ras family, RhoGAP and RasGAP exhibit no similarity at their amino acid sequence level. RasGTPases function as molecular switches in a large number of signaling pathways. They are in the on state when bound to GTP, and in the off state when bound to GDP. The RasGAP domain speeds up the hydrolysis of GTP in Ras-like proteins acting as a negative regulator.


Pssm-ID: 213328  Cd Length: 256  Bit Score: 45.95  E-value: 1.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1614 LFLTKFIHTLESQ--RTFSARDRAYVASLLTVALHGKlEYFTDILRTLLSDLVAQyvAKNPKLMLRRTeTVVEKLLTNWM 1691
Cdd:cd04519     8 LLLTESPLALLRElsQVLPVKDKEEVATALLRIFESR-GLALEFLRYLVRSEVKN--TKNPNTLFRGN-SLATKLLDQYM 83

                          90       100       110
                  ....*....|....*....|....*....|...
gi 194272180 1692 SICLYTFVRDSVGEPLYMLFRGIKHQVDKGPVD 1724
Cdd:cd04519    84 KLVGQEYLKETLSPLIREILESKESCEIDTKLP 116
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 681-825 1.36e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 47.02  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  681 SPDPPARGGPSPSPPTAPKALATPAPdtlpVEPGAPSTATASdisPGASPSllSPWGPWAGSGSISSPGSTGSPLHEEPS 760
Cdd:PRK14951  380 TPARPEAAAPAAAPVAQAAAAPAPAA----APAAAASAPAAP---PAAAPP--APVAAPAAAAPAAAPAAAPAAVALAPA 450

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194272180  761 PPSPQNGPGTAVPAPTDFRPsatpedllasplSPSEVAAVPPADPGPEALHPTVPLDLPPATVPA 825
Cdd:PRK14951  451 PPAQAAPETVAIPVRVAPEP------------AVASAAPAPAAAPAAARLTPTEEGDVWHATVQQ 503
Sema_6 cd11242
The Sema domain, a protein interacting module, of class 6 semaphorins (Sema6); Class 6 ...
 217-443 1.62e-04

The Sema domain, a protein interacting module, of class 6 semaphorins (Sema6); Class 6 semaphorins (Sema6s) are membrane associated semaphorins. There are 6 subfamilies named 6A to 6D. Sema6s bind to plexin As in a neuropilin independent fashion. Sema6-plexin A signaling plays important roles in lamina-specific axon projections. Interactions between plexin A2, plexin A4, and Sema6A control lamina-restricted projection of hippocampal mossy fibers. Interactions between Sema6C, Sema6D and plexin A1 shape the stereotypic trajectories of sensory axons in the spinal cord. In addition to axon targeting, Sema6D-plexin A1 interactions influence a wide range of other biological processes. During cardiac development, Sema6D attracts or repels endothelial cells in the cardiac tube depending on the expression patterns of specific coreceptors in addition to plexin A1. Furthermore, Sema6D binds a receptor complex comprising of plexin A1, Trem2 (triggering receptor expressed on myeloid cells 2), and DAP12 on dendritic cells and osteoclasts to mediate T-cell-DC interactions and to control bone development, respectively. The Sema domain is located at the N-terminus and contains four disulfide bonds formed by eight conserved cysteine residues. It serves as a receptor-recognition and -binding module.


Pssm-ID: 200503 [Multi-domain]  Cd Length: 465  Bit Score: 46.74  E-value: 1.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  217 HFVSAFARGASAYFLFlrRDLQAQ----SRAFRAYVSRVCLRD---------QHYYSYVELPLACE--GGR---YGLIQa 278
Cdd:cd11242   174 HFVHAVEYGDYVYFFF--REIAVEyntlGKVVFSRVARVCKNDmggsprvleKQWTSFLKARLNCSvpGDShfyFDVLQ- 250

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  279 aAVATSREVAHGEVLFAAFSSAAPPTVGrppsaaagasgaSALCAFPLDEVDRLAN------RTRDACYT---------- 342
Cdd:cd11242   251 -AVTDVIRINGRPVVLGVFTTQYNSIPG------------SAVCAFDMDDIEKVFEgrfkeqKSPDSAWTpvpedrvpkp 317

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  343 REGR-AEDGTEVAYieydvnSDCAQLPVDTLD---AYPCgsdhtpspMASRVPleatPILEWPGI-------QLTAVAVT 411
Cdd:cd11242   318 RPGCcAGSGSAEKY------KTSNDFPDDTLNfikTHPL--------MDEAVP----SIINRPWFtrtmvryRLTQIAVD 379

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 194272180  412 MEDG----HTIAFLGDSQGQLHRVYLGPGSDGHPYS 443
Cdd:cd11242   380 NAAGpyqnYTVVFLGSEAGTVLKFLARIGPSGSNGS 415
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 668-781 1.89e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 46.63  E-value: 1.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  668 AGPMVASHQSPLVSPDPPARGGPSPSPPtaPKALATPAPDTLPVEPGAPSTATASDISPGASPSLLSPWGPWAGSGSISS 747
Cdd:PRK14951  379 KTPARPEAAAPAAAPVAQAAAAPAPAAA--PAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQAA 456

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 194272180  748 PGSTGSPLHEEPSPPSPQNGPG-TAVPAPTDFRPS 781
Cdd:PRK14951  457 PETVAIPVRVAPEPAVASAAPApAAAPAAARLTPT 491
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 661-882 2.69e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 46.06  E-value: 2.69e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   661 THKASCDAGPmvashQSPLVSPDPPARGGPSPSPPTA-PKALATPAPDTLPVEPGaPSTATASDISP-------GASPSL 732
Cdd:pfam05109  416 THKVIFSKAP-----ESTTTSPTLNTTGFAAPNTTTGlPSSTHVPTNLTAPASTG-PTVSTADVTSPtpagttsGASPVT 489

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   733 LSPwGPwAGSGSISSPGSTGSPLHEEPSPPSPQNGPGTAVPAPTdfrPSATPEDLlaSPLSPSEVAAVPpaDPGPEALHP 812
Cdd:pfam05109  490 PSP-SP-RDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTPT---PNATSPTL--GKTSPTSAVTTP--TPNATSPTP 560

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 194272180   813 TVPLDLPPATVPattfpgAMGSVKPALDWLTreggELPEADEWTGGDAP--AFSTSTLLSGDGDSAELEGPP 882
Cdd:pfam05109  561 AVTTPTPNATIP------TLGKTSPTSAVTT----PTPNATSPTVGETSpqANTTNHTLGGTSSTPVVTSPP 622
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
678-879 4.63e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 45.61  E-value: 4.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  678 PLVSPDPPARGGPSPSPP---TAPKALATPAPDTLPVEPGAPSTATASDispGASPSLLSPwgpwAGSGSISSPGSTGSP 754
Cdd:PRK07003  360 PAVTGGGAPGGGVPARVAgavPAPGARAAAAVGASAVPAVTAVTGAAGA---ALAPKAAAA----AAATRAEAPPAAPAP 432

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  755 LHEEPSPPSPQNGPGTA-VPAPTDFRPSATPEDLLASPLSPSEVAAVPPAD-PGPEALHPTVPLDLPPATVPATTFPGAM 832
Cdd:PRK07003  433 PATADRGDDAADGDAPVpAKANARASADSRCDERDAQPPADSGSASAPASDaPPDAAFEPAPRAAAPSAATPAAVPDARA 512

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 194272180  833 GSVKPALDWLTREGGELPEAdewtGGDAPAFSTSTLLSGdGDSAELE 879
Cdd:PRK07003  513 PAAASREDAPAAAAPPAPEA----RPPTPAAAAPAARAG-GAAAALD 554
Gag_spuma pfam03276
Spumavirus gag protein;
670-839 7.28e-04

Spumavirus gag protein;


Pssm-ID: 460872 [Multi-domain]  Cd Length: 614  Bit Score: 44.74  E-value: 7.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   670 PMVASHQSPLVSPDPPARGGPSPSPPTA---PKALATPAPDTLPVEPGAPSTATASDISPGASPSLLSPWGPWAGSGSIS 746
Cdd:pfam03276  187 PPGASFSGLPSLPAIGGIHLPAIPGIHArapPGNIARSLGDDIMPSLGDAGMPQPRFAFHPGNPFAEAEGHPFAEAEGER 266

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   747 SPGSTGSPLHEEPSPPSPqngpgtavPAPtdfRPSATPEDLLASPLSPSEVAAVPPADP--GPEALHPTVPLDLPPAT-V 823
Cdd:pfam03276  267 PRDIPRAPRIDAPSAPAI--------PAI---QPIAPPMIPPIGAPIPIPHGASIPGEHirNPREEPIRLGREAPAIDgR 335

                          170
                   ....*....|....*.
gi 194272180   824 PATTFPGAMGSVKPAL 839
Cdd:pfam03276  336 FAPAIDDLFCRIINAL 351
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 678-898 9.59e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 44.30  E-value: 9.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  678 PLVSPDPPARGGP-SPSPPTAPKALATPAPDTLPVEPGAPSTATASDI--SPGASPSLLSPWGPWAGSGSISSPGSTGSP 754
Cdd:PTZ00449  573 PTLSKKPEFPKDPkHPKDPEEPKKPKRPRSAQRPTRPKSPKLPELLDIpkSPKRPESPKSPKRPPPPQRPSSPERPEGPK 652

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  755 LHEEPSPP-SPQngpgtaVPAPTDFR----------PSATPEDLLASPLSPSEVAAVPPADPGPEALHPTVPLDLPPA-- 821
Cdd:PTZ00449  653 IIKSPKPPkSPK------PPFDPKFKekfyddyldaAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKlp 726

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  822 TVPATTF--PGAMGSVKPAldwlTREGGELPEAD----EWTGGDAPAFSTSTLLSGDGD-SAELEGPPAPLILPSSLDYQ 894
Cdd:PTZ00449  727 RDEEFPFepIGDPDAEQPD----DIEFFTPPEEErtffHETPADTPLPDILAEEFKEEDiHAETGEPDEAMKRPDSPSEH 802


                  ....
gi 194272180  895 YDTP 898
Cdd:PTZ00449  803 EDKP 806
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 674-815 1.21e-03

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 43.31  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  674 SHQSPLvSPDP----PARGGPSPSPPTAPKALATPAPdtlpvepgapstatasdiSPGASPSLLSPWGPWAGSGSISSPG 749
Cdd:PHA02682   77 SGQSPL-APSPacaaPAPACPACAPAAPAPAVTCPAP------------------APACPPATAPTCPPPAVCPAPARPA 137

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194272180  750 STGSPLHEE--PSPPSPQNGPGTAVpAPTDFRPSATPEDLLASPLSPSEVAavPPADPgpeALHPTVP 815
Cdd:PHA02682  138 PACPPSTRQcpPAPPLPTPKPAPAA-KPIFLHNQLPPPDYPAASCPTIETA--PAASP---VLEPRIP 199
KREPA2 cd23959
Kinetoplastid RNA Editing Protein A2 (KREPA2); The KREPA2 (TbMP63) protein is a component of ...
 685-838 1.70e-03

Kinetoplastid RNA Editing Protein A2 (KREPA2); The KREPA2 (TbMP63) protein is a component of the parasitic protozoan's KREPA RNA editing catalytic complex (RECC). Kinetoplastid RNA editing (KRE) proteins occur as pairs or sets of related proteins in multiple complexes. KREPA complex is composed of six components (KREPA1-6), which share a conserved C-terminal region containing an oligonucleotide-binding (OB)-fold-like domain. KREPAs are responsible for the site-specific insertion and deletion of U nucleotides in the kinetoplastid mitochondria pre-messenger RNA. Apart from the conserved C-terminal OB-fold domain, KREPA1, KREPA2, and KREPA3 contain two conserved C2H2 zinc-finger domains. KREPA2 and kinetoplastid RNA editing ligase 1 (KREL1) are specific for ligation post-U-deletion and are paralogous to KREL2 and KREPA1 that are specific for ligation post-U-insertion. KREPA2, is critical for RECC stability and KREL1 integration into the complex.


Pssm-ID: 467780 [Multi-domain]  Cd Length: 424  Bit Score: 43.32  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  685 PARGGPSPSPPTAPKALATPAPDTLPVEP------GAPSTATASDISPGASPsllspwgpwagsgsisspgstgsplheE 758
Cdd:cd23959   109 PFRAARVPNPFSASSSTQRETHKTAQVAPpkaepqTAPVTPFGQLPMFGQHP---------------------------P 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  759 PSPPSPQNGPGTAVPAPTDFrpsatpedlLASPLSPSEVAAVPPADPGPEALHPTVPLDLPP-ATVPATTFPGAMGSVKP 837
Cdd:cd23959   162 PAKPLPAAAAAQQSSASPGE---------VASPFASGTVSASPFATATDTAPSSGAPDGFPAeASAPSPFAAPASAASFP 232


                  .
gi 194272180  838 A 838
Cdd:cd23959   233 A 233
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1252-1374 1.81e-03

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 39.13  E-value: 1.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180 1252 PNITSAGPTKSFLSGGREICVRGQNLDVvqtprirvtvvsrmlqpsqglGRRRRVvpetacSLGpscssqqfEEPCH--- 1328
Cdd:cd01179     1 PSITSLSPSYGPQSGGTRLTITGKHLNA---------------------GSSVRV------TVG--------GQPCKils 45

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 194272180 1329 VNSSQlITCRTPALPGLPEdpwVRVEfildnLVFDFA-TLNPTPFSY 1374
Cdd:cd01179    46 VSSSQ-IVCLTPPSASPGE---APVK-----VLIDGArRLAPLVFTY 83
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 759-862 3.23e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 42.49  E-value: 3.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  759 PSPPSPQNGPGTAVPAPTdfRPSATPedllASPLSPSEVAAVPPADPGPEALHPTV--------PLDLPPATVPATTFPG 830
Cdd:PRK14950  362 PVPAPQPAKPTAAAPSPV--RPTPAP----STRPKAAAAANIPPKEPVRETATPPPvpprpvapPVPHTPESAPKLTRAA 435

                          90       100       110
                  ....*....|....*....|....*....|..
gi 194272180  831 AMGSVKPALDwltregGELPEADEWTGGDAPA 862
Cdd:PRK14950  436 IPVDEKPKYT------PPAPPKEEEKALIADG 461
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 681-823 3.25e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 3.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  681 SPDPPARGGPSPSPPTAPKAlATPAPDTLPVEPGAPSTATASDISPGASPSllspwgpwagsgsisspgSTGSPLHEEPS 760
Cdd:PRK07764  393 APAAAAPSAAAAAPAAAPAP-AAAAPAAAAAPAPAAAPQPAPAPAPAPAPP------------------SPAGNAPAGGA 453

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 194272180  761 PPSPQNGPGTAVPAPTdfrPSATPEDLLASPLSPSEVAAvPPADPGPEALHPTVPLDLPPATV 823
Cdd:PRK07764  454 PSPPPAAAPSAQPAPA---PAAAPEPTAAPAPAPPAAPA-PAAAPAAPAAPAAPAGADDAATL 512
PSI pfam01437
Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The ...
 641-666 3.64e-03

Plexin repeat; A cysteine rich repeat found in several different extracellular receptors. The function of the repeat is unknown. Three copies of the repeat are found Plexin. Two copies of the repeat are found in mahogany protein. A related C. elegans protein contains four copies of the repeat. The Met receptor contains a single copy of the repeat. The Pfam alignment shows 6 conserved cysteine residues that may form three conserved disulphide bridges, whereas some members show 8 conserved cysteines. The pattern of conservation suggests that cysteines 5 and 7 (that are not absolutely conserved) form a disulphide bridge (Personal observation. A Bateman).


Pssm-ID: 396154 [Multi-domain]  Cd Length: 52  Bit Score: 37.30  E-value: 3.64e-03
                           10        20
                   ....*....|....*....|....*..
gi 194272180   641 CQACVSSR-WGCNWCVWQHLCTHKASC 666
Cdd:pfam01437    8 CSSCLAARdPYCGWCSSEGRCVRRSAC 34
half-pint TIGR01645
poly-U binding splicing factor, half-pint family; The proteins represented by this model ...
 696-880 5.23e-03

poly-U binding splicing factor, half-pint family; The proteins represented by this model contain three RNA recognition motifs (rrm: pfam00076) and have been characterized as poly-pyrimidine tract binding proteins associated with RNA splicing factors. In the case of PUF60 (GP|6176532), in complex with p54, and in the presence of U2AF, facilitates association of U2 snRNP with pre-mRNA.


Pssm-ID: 130706 [Multi-domain]  Cd Length: 612  Bit Score: 41.98  E-value: 5.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   696 TAPKALATPA-PDTLPVEPG---APSTA--TASDISPGAS---PSLLSPWGPWAGSGSISSPGSTGSPLHEEPS--PPSP 764
Cdd:TIGR01645  283 TPPDALLQPAtVSAIPAAAAvaaAAATAkiMAAEAVAGAAvlgPRAQSPATPSSSLPTDIGNKAVVSSAKKEAEevPPLP 362

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180   765 QNGPGTAVPAPTDFrPSATPEDLLASPLSPSEVAAVPPADPGPEAL-HPTVPLDLppatvpaTTFPGAMGSVKPALDWLT 843
Cdd:TIGR01645  363 QAAPAVVKPGPMEI-PTPVPPPGLAIPSLVAPPGLVAPTEINPSFLaSPRKKMKR-------EKLPVTFGALDDTLAWKE 434

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 194272180   844 REGGELPEADEWTGGDAPAFSTSTLLSGDGDSAELEG 880
Cdd:TIGR01645  435 PSKEDQTSEDGKMLAIMGEAAAALALEPKKKKKEKEG 471
PTZ00436 PTZ00436
60S ribosomal protein L19-like protein; Provisional
 657-829 5.66e-03

60S ribosomal protein L19-like protein; Provisional


Pssm-ID: 185616 [Multi-domain]  Cd Length: 357  Bit Score: 41.47  E-value: 5.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  657 QHLCTHKASCDAGPMVASHQSPLVSPDPPARGGPSPSPPTAPKALATPAPDTLPVEPGAPSTATASDISPGASPSllspw 736
Cdd:PTZ00436  201 QKAAAKKAAAPSGKKSAKAAAPAKAAAAPAKAAAPPAKAAAAPAKAAAAPAKAAAPPAKAAAPPAKAAAPPAKAA----- 275

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  737 gpwagsgsisspgstGSPLHEEPSPPSPQNGPGTAVPAPTdfRPSATPEDLLASPlspSEVAAVPPADPGPEALHPTVPL 816
Cdd:PTZ00436  276 ---------------APPAKAAAPPAKAAAPPAKAAAAPA--KAAAAPAKAAAAP---AKAAAPPAKAAAPPAKAATPPA 335

                         170
                  ....*....|...
gi 194272180  817 DLPPATVPATTFP 829
Cdd:PTZ00436  336 KAAAPPAKAAAAP 348
PHA03247 PHA03247
large tegument protein UL36; Provisional
 684-839 5.70e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 5.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  684 PPARGGPSPSPPTAPKALATPAPDTLPvEPgAPSTATASDISPGASPSLLSPWGPWAGSGSISSPGSTGSPLHEEPSPPS 763
Cdd:PHA03247 2861 DVRRRPPSRSPAAKPAAPARPPVRRLA-RP-AVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPR 2938

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 194272180  764 PQNgpgtavPAPTDFRPSATPEDLLASPlSPSEVAAVPPADPGPEALhptVPLDLPPATVPATTFPGAMGSVKPAL 839
Cdd:PHA03247 2939 PQP------PLAPTTDPAGAGEPSGAVP-QPWLGALVPGRVAVPRFR---VPQPAPSREAPASSTPPLTGHSLSRV 3004
PHA03201 PHA03201
uracil DNA glycosylase; Provisional
 759-841 8.39e-03

uracil DNA glycosylase; Provisional


Pssm-ID: 165468  Cd Length: 318  Bit Score: 40.65  E-value: 8.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194272180  759 PSPPSPQNGPGTAVPAPTDFRPSATPEDLLASPLSPSEVAAVPPADP--GPEALHPTVPLDLPPATVPATTFPGAMGSVK 836
Cdd:PHA03201    9 PSPPRRPSPPRPTPPRSPDASPEETPPSPPGPGAEPPPGRAAGPAAPrrRPRGCPAGVTFSSSAPPRPPLGLDDAPAATP 88


                  ....*
gi 194272180  837 PALDW 841
Cdd:PHA03201   89 PPLDW 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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