WASH complex subunit 4 family protein is a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization
WASH complex subunit 7; This family is the central, conserved region of proteins that form ...
591-934
4.99e-154
WASH complex subunit 7; This family is the central, conserved region of proteins that form subunit 7 of the WASH complex. In species such as Drosophila this protein is the only component of the 'complex'. This complex is a nucleation promoting factor necessary for the activation of Arp2/3 that nucleates and organizes actin filaments by associating with a pre-existing filament to induce the assembly of a branching filament. WASH thus effectively nucleates actin on endosomes.
:
Pssm-ID: 434177 Cd Length: 346 Bit Score: 462.84 E-value: 4.99e-154
WASH complex subunit 4, N-terminal; This entry is the conserved N-terminal region of proteins ...
18-584
1.46e-91
WASH complex subunit 4, N-terminal; This entry is the conserved N-terminal region of proteins that form subunit 4 of the WASH complex, also known as subunit 7 or KIAA1033/SWIP. In species such as Drosophila this protein is the only component of the 'complex'. This complex is present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. This domain comprises the WAHD1 and the TBR (tubulin-binding region) domains.
The actual alignment was detected with superfamily member pfam14745:
Pssm-ID: 434178 Cd Length: 566 Bit Score: 305.01 E-value: 1.46e-91
WASH complex subunit 7, C-terminal; This family is the conserved C-terminal region of proteins ...
951-1132
2.73e-69
WASH complex subunit 7, C-terminal; This family is the conserved C-terminal region of proteins that form subunit 7 of the WASH complex. In species such as Drosophila this protein is the only component of the 'complex'. This complex is a nucleation promoting factor necessary for the activation of Arp2/3 that nucleates and organizes actin filaments by associating with a pre-existing filament to induce the assembly of a branching filament. WASH thus effectively nucleates actin on endosomes. The C-terminus is predicted to include a transmembrane region.
:
Pssm-ID: 464293 Cd Length: 175 Bit Score: 229.44 E-value: 2.73e-69
WASH complex subunit 7; This family is the central, conserved region of proteins that form ...
591-934
4.99e-154
WASH complex subunit 7; This family is the central, conserved region of proteins that form subunit 7 of the WASH complex. In species such as Drosophila this protein is the only component of the 'complex'. This complex is a nucleation promoting factor necessary for the activation of Arp2/3 that nucleates and organizes actin filaments by associating with a pre-existing filament to induce the assembly of a branching filament. WASH thus effectively nucleates actin on endosomes.
Pssm-ID: 434177 Cd Length: 346 Bit Score: 462.84 E-value: 4.99e-154
WASH complex subunit 4, N-terminal; This entry is the conserved N-terminal region of proteins ...
18-584
1.46e-91
WASH complex subunit 4, N-terminal; This entry is the conserved N-terminal region of proteins that form subunit 4 of the WASH complex, also known as subunit 7 or KIAA1033/SWIP. In species such as Drosophila this protein is the only component of the 'complex'. This complex is present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. This domain comprises the WAHD1 and the TBR (tubulin-binding region) domains.
Pssm-ID: 434178 Cd Length: 566 Bit Score: 305.01 E-value: 1.46e-91
WASH complex subunit 7, C-terminal; This family is the conserved C-terminal region of proteins ...
951-1132
2.73e-69
WASH complex subunit 7, C-terminal; This family is the conserved C-terminal region of proteins that form subunit 7 of the WASH complex. In species such as Drosophila this protein is the only component of the 'complex'. This complex is a nucleation promoting factor necessary for the activation of Arp2/3 that nucleates and organizes actin filaments by associating with a pre-existing filament to induce the assembly of a branching filament. WASH thus effectively nucleates actin on endosomes. The C-terminus is predicted to include a transmembrane region.
Pssm-ID: 464293 Cd Length: 175 Bit Score: 229.44 E-value: 2.73e-69
WASH complex subunit 7; This family is the central, conserved region of proteins that form ...
591-934
4.99e-154
WASH complex subunit 7; This family is the central, conserved region of proteins that form subunit 7 of the WASH complex. In species such as Drosophila this protein is the only component of the 'complex'. This complex is a nucleation promoting factor necessary for the activation of Arp2/3 that nucleates and organizes actin filaments by associating with a pre-existing filament to induce the assembly of a branching filament. WASH thus effectively nucleates actin on endosomes.
Pssm-ID: 434177 Cd Length: 346 Bit Score: 462.84 E-value: 4.99e-154
WASH complex subunit 4, N-terminal; This entry is the conserved N-terminal region of proteins ...
18-584
1.46e-91
WASH complex subunit 4, N-terminal; This entry is the conserved N-terminal region of proteins that form subunit 4 of the WASH complex, also known as subunit 7 or KIAA1033/SWIP. In species such as Drosophila this protein is the only component of the 'complex'. This complex is present at the surface of endosomes that recruits and activates the Arp2/3 complex to induce actin polymerization. This domain comprises the WAHD1 and the TBR (tubulin-binding region) domains.
Pssm-ID: 434178 Cd Length: 566 Bit Score: 305.01 E-value: 1.46e-91
WASH complex subunit 7, C-terminal; This family is the conserved C-terminal region of proteins ...
951-1132
2.73e-69
WASH complex subunit 7, C-terminal; This family is the conserved C-terminal region of proteins that form subunit 7 of the WASH complex. In species such as Drosophila this protein is the only component of the 'complex'. This complex is a nucleation promoting factor necessary for the activation of Arp2/3 that nucleates and organizes actin filaments by associating with a pre-existing filament to induce the assembly of a branching filament. WASH thus effectively nucleates actin on endosomes. The C-terminus is predicted to include a transmembrane region.
Pssm-ID: 464293 Cd Length: 175 Bit Score: 229.44 E-value: 2.73e-69
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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