|
Name |
Accession |
Description |
Interval |
E-value |
| MoeA |
COG0303 |
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; ... |
1-416 |
1.05e-116 |
|
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; Molybdopterin Mo-transferase (molybdopterin biosynthesis) is part of the Pathway/BioSystem: Molybdopterin biosynthesis
Pssm-ID: 440072 [Multi-domain] Cd Length: 401 Bit Score: 346.31 E-value: 1.05e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 1 MRSVEDQLAIVVDAAPVPEPIRVGITDALGLMCAEEVSAANPLPGFPQAAVDGYAVRAVDVGGGvalgsgpekdRPVErs 80
Cdd:COG0303 1 MISVEEALALILAAVRPLGTETVPLAEALGRVLAEDVVAPRDVPPFDNSAMDGYAVRAADLAGA----------NPVT-- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 81 LPVVGEVAAGSQKPLRLQPKQAVRVATGAPLPTLADAVLPLQWSDRGRKRVTPSRPVRTGDFVRKAGDDIQPGDVAVRQG 160
Cdd:COG0303 69 LRVVGEIAAGSPPPGPLGPGEAVRIMTGAPLPEGADAVVMQEDTEREGDRVTIRKPVAPGENIRRAGEDIAAGDVLLPAG 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 161 SVLGPAQIGLLAASGRDKVLVYPRPRVTVMSFGLELVDIERDPGLGQVYDVASYAVAAAAKEAGATVTRAGIINAEPRRL 240
Cdd:COG0303 149 TRLTPADLGLLASLGIAEVPVYRRPRVAILSTGDELVEPGEPLGPGQIYDSNSYMLAALLREAGAEVVDLGIVPDDPEAL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 241 KETIAHQASRSEMLIITGAVGGSGAEPVQNVLRDLG-EIDTTRVAMHPGSVQGFGLVGEerIPVFLLPPNTVSSLVIFEA 319
Cdd:COG0303 229 RAALREALAEADLVITSGGVSVGDYDLVKEALEELGaEVLFHKVAMKPGKPLAFGRLGG--KPVFGLPGNPVSALVTFEL 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 320 LIRPTIRQSLGKAEPTRRTVQARSLGRIESLPGRLGLVRGRLMRDAetGDYLVQSLSGAEgapAHLLAGFAEANALIRIP 399
Cdd:COG0303 307 FVRPALRKLAGLPPPPPPRVRARLAEDLPKKPGRTEFLRVRLERDD--GELVVEPLGGQG---SGLLSSLAEADGLIVLP 381
|
410
....*....|....*..
gi 1939565266 400 RDITEVRPGDLVDVEFL 416
Cdd:COG0303 382 EGVEGVEAGEEVEVLLL 398
|
|
| MoeA |
cd00887 |
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor ... |
4-416 |
2.93e-110 |
|
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.
Pssm-ID: 238452 [Multi-domain] Cd Length: 394 Bit Score: 329.45 E-value: 2.93e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 4 VEDQLAIVVDAAPVPEPIRVGITDALGLMCAEEVSAANPLPGFPQAAVDGYAVRAVDVGGGVAlgsgpekdrpverSLPV 83
Cdd:cd00887 1 VEAARELLLALAPPLGTETVPLLEALGRVLAEDVVAPIDLPPFDNSAMDGYAVRAADTAGASV-------------TLRV 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 84 VGEVAAGSQKPLRLQPKQAVRVATGAPLPTLADAVLPLQWSDRGRKRVTPSRPVRTGDFVRKAGDDIQPGDVAVRQGSVL 163
Cdd:cd00887 68 VGEIPAGEPPDGPLGPGEAVRIMTGAPLPEGADAVVMVEDTEEEGGRVTITKPVKPGQNIRRAGEDIKAGDVLLPAGTRL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 164 GPAQIGLLAASGRDKVLVYPRPRVTVMSFGLELVDIERDPGLGQVYDVASYAVAAAAKEAGATVTRAGIINAEPRRLKET 243
Cdd:cd00887 148 TPADIGLLASLGIAEVPVYRRPRVAIISTGDELVEPGEPLAPGQIYDSNSYMLAALLRELGAEVVDLGIVPDDPEALREA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 244 IAHQASRSEMLIITGAVGGSGAEPVQNVLRDL-GEIDTTRVAMHPGSVQGFGLVGEerIPVFLLPPNTVSSLVIFEALIR 322
Cdd:cd00887 228 LEEALEEADVVITSGGVSVGDYDFVKEVLEELgGEVLFHGVAMKPGKPLAFGRLGG--KPVFGLPGNPVSALVTFELFVR 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 323 PTIRQSLGKAEPTRRTVQARSLGRIESLPGRLGLVRGRLMRDAetGDYLVQSLSGAEgapAHLLAGFAEANALIRIPRDI 402
Cdd:cd00887 306 PALRKLQGAPEPEPPRVKARLAEDLKSKPGRREFLRVRLERDE--GGLVVAPPGGQG---SGLLSSLARADGLIVIPEGV 380
|
410
....*....|....
gi 1939565266 403 TEVRPGDLVDVEFL 416
Cdd:cd00887 381 EGLEAGEEVEVLLL 394
|
|
| PRK14498 |
PRK14498 |
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing ... |
1-416 |
1.46e-62 |
|
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional
Pssm-ID: 237732 [Multi-domain] Cd Length: 633 Bit Score: 212.77 E-value: 1.46e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 1 MRSVEDQLAIVVDA--APVPEPIRVGITDALGLMCAEEVSAANPLPGFPQAAVDGYAVRAVDVgggvalgSGPEKDRPVE 78
Cdd:PRK14498 9 LVSLEEAREILESLlsELPLGTEEVPLEEALGRVLAEDVYAPIDVPPFDRSAMDGYAVRAADT-------FGASEANPVR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 79 rsLPVVGEVAAGSQKPLRLQPKQAVRVATGAPLPTLADAVLPLQWSDR-GRKRVTPSRPVRTGDFVRKAGDDIQPGDVAV 157
Cdd:PRK14498 82 --LKLGGEVHAGEAPDVEVEPGEAVEIATGAPIPRGADAVVMVEDTEEvDDDTVEIYRPVAPGENVRPAGEDIVAGELIL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 158 RQGSVLGPAQIGLLAASGRDKVLVYPRPRVTVMSFGLELVDIERDPGLGQVYDVASYAVAAAAKEAGATVTRAGIINAEP 237
Cdd:PRK14498 160 PKGTRLTPRDIGALAAGGVAEVPVYKKPRVGIISTGDELVEPGEPLKPGKIYDVNSYTLAAAVEEAGGEPVRYGIVPDDE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 238 RRLKETIAHQASRSEMLIITGavGGS-GAEPV-QNVLRDLGEIDTTRVAMHPGSVQGFGLVGEEriPVFLLPPNTVSSLV 315
Cdd:PRK14498 240 EELEAALRKALKECDLVLLSG--GTSaGAGDVtYRVIEELGEVLVHGVAIKPGKPTILGVIGGK--PVVGLPGYPVSALT 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 316 IFEALIRPTIRQSLGKAEPTRRTVQARSLGRIESLPGRLGLVRGRLMRDAETgdYLVQSLSGAEGApahlLAGFAEANAL 395
Cdd:PRK14498 316 IFEEFVAPLLRKLAGLPPPERATVKARLARRVRSELGREEFVPVSLGRVGDG--YVAYPLSRGSGA----ITSLVRADGF 389
|
410 420
....*....|....*....|.
gi 1939565266 396 IRIPRDITEVRPGDLVDVEFL 416
Cdd:PRK14498 390 IEIPANTEGLEAGEEVEVELF 410
|
|
| MoeA_N |
pfam03453 |
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of ... |
16-175 |
2.33e-35 |
|
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of these contains the conserved DGXA motif. This region is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this region is uncertain.
Pssm-ID: 460923 [Multi-domain] Cd Length: 147 Bit Score: 127.30 E-value: 2.33e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 16 PVPEPIRVGITDALGLMCAEEVSAANPLPGFPQAAVDGYAVRAVDvgggvalGSGPEKDRPVerslpvvgevAAGSQKPL 95
Cdd:pfam03453 4 GTEETVPLEALDALGRVLAEDVVAPRDVPPFDRSAMDGYAVRAAD-------GFGASEVNPI----------AAGEPPGP 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 96 RLQPKQAVRVATGAPLPTLADAVLPLQW-SDRGRKRVTPSRPVRTGDFVRKAGDDIQPGDVAVRQGSVLGPAQIGLLAAS 174
Cdd:pfam03453 67 LLPGGEAVRIMTGAPLPEGADAVVMVEDtEEGGGRTVEIRAPVAPGENVRRAGEDIKAGEVVLPAGTRLTPAEIGLLASL 146
|
.
gi 1939565266 175 G 175
Cdd:pfam03453 147 G 147
|
|
| molyb_syn |
TIGR00177 |
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein ... |
185-323 |
3.79e-15 |
|
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein cnx1, and rat protein gephyrin each have one domain like MoeA and one like MoaB and Mog. These domains are, however, distantly related to each other, as captured by this model. Gephyrin is unusual in that it seems to be a tubulin-binding neuroprotein involved in the clustering of both blycine receptors and GABA receptors, rather than a protein of molybdenum cofactor biosynthesis.
Pssm-ID: 272944 [Multi-domain] Cd Length: 148 Bit Score: 72.35 E-value: 3.79e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 185 PRVTVMSFGLELVDIERDPGLGQVYDVASYAVAAAAKEAGATVTRAGIINAEPRRLKETIAHQASRSEMLIITGAVGGSG 264
Cdd:TIGR00177 1 PRVAVISVGDELVEGGQPLEPGQIYDSNGPLLAALLQEAGFNVVRLGIVPDDPEEIREILRKAVDEADVVLTTGGTGVGP 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 265 AEPVQNVLRDLGEI-----------DTTRVAMHPGSVQGFGLVGeeRIPVFLLPPNTVSSLVIFEALIRP 323
Cdd:TIGR00177 81 RDVTPEALEELGEKeipgfgefrmlSSLPVLSRPGKPATAGVRG--GTLIFNLPGNPVSALVTFEVLILP 148
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MoeA |
COG0303 |
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; ... |
1-416 |
1.05e-116 |
|
Molybdopterin Mo-transferase (molybdopterin biosynthesis) [Coenzyme transport and metabolism]; Molybdopterin Mo-transferase (molybdopterin biosynthesis) is part of the Pathway/BioSystem: Molybdopterin biosynthesis
Pssm-ID: 440072 [Multi-domain] Cd Length: 401 Bit Score: 346.31 E-value: 1.05e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 1 MRSVEDQLAIVVDAAPVPEPIRVGITDALGLMCAEEVSAANPLPGFPQAAVDGYAVRAVDVGGGvalgsgpekdRPVErs 80
Cdd:COG0303 1 MISVEEALALILAAVRPLGTETVPLAEALGRVLAEDVVAPRDVPPFDNSAMDGYAVRAADLAGA----------NPVT-- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 81 LPVVGEVAAGSQKPLRLQPKQAVRVATGAPLPTLADAVLPLQWSDRGRKRVTPSRPVRTGDFVRKAGDDIQPGDVAVRQG 160
Cdd:COG0303 69 LRVVGEIAAGSPPPGPLGPGEAVRIMTGAPLPEGADAVVMQEDTEREGDRVTIRKPVAPGENIRRAGEDIAAGDVLLPAG 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 161 SVLGPAQIGLLAASGRDKVLVYPRPRVTVMSFGLELVDIERDPGLGQVYDVASYAVAAAAKEAGATVTRAGIINAEPRRL 240
Cdd:COG0303 149 TRLTPADLGLLASLGIAEVPVYRRPRVAILSTGDELVEPGEPLGPGQIYDSNSYMLAALLREAGAEVVDLGIVPDDPEAL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 241 KETIAHQASRSEMLIITGAVGGSGAEPVQNVLRDLG-EIDTTRVAMHPGSVQGFGLVGEerIPVFLLPPNTVSSLVIFEA 319
Cdd:COG0303 229 RAALREALAEADLVITSGGVSVGDYDLVKEALEELGaEVLFHKVAMKPGKPLAFGRLGG--KPVFGLPGNPVSALVTFEL 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 320 LIRPTIRQSLGKAEPTRRTVQARSLGRIESLPGRLGLVRGRLMRDAetGDYLVQSLSGAEgapAHLLAGFAEANALIRIP 399
Cdd:COG0303 307 FVRPALRKLAGLPPPPPPRVRARLAEDLPKKPGRTEFLRVRLERDD--GELVVEPLGGQG---SGLLSSLAEADGLIVLP 381
|
410
....*....|....*..
gi 1939565266 400 RDITEVRPGDLVDVEFL 416
Cdd:COG0303 382 EGVEGVEAGEEVEVLLL 398
|
|
| MoeA |
cd00887 |
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor ... |
4-416 |
2.93e-110 |
|
MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and eukaryotes. MoCF contains a tricyclic pyranopterin, termed molybdopterin (MPT). MoeA, together with MoaB, is responsible for the metal incorporation into MPT, the third step in MoCF biosynthesis. The plant homolog Cnx1 is a MoeA-MogA fusion protein. The mammalian homolog gephyrin is a MogA-MoeA fusion protein, that plays a critical role in postsynaptic anchoring of inhibitory glycine receptors and major GABAa receptor subtypes.
Pssm-ID: 238452 [Multi-domain] Cd Length: 394 Bit Score: 329.45 E-value: 2.93e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 4 VEDQLAIVVDAAPVPEPIRVGITDALGLMCAEEVSAANPLPGFPQAAVDGYAVRAVDVGGGVAlgsgpekdrpverSLPV 83
Cdd:cd00887 1 VEAARELLLALAPPLGTETVPLLEALGRVLAEDVVAPIDLPPFDNSAMDGYAVRAADTAGASV-------------TLRV 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 84 VGEVAAGSQKPLRLQPKQAVRVATGAPLPTLADAVLPLQWSDRGRKRVTPSRPVRTGDFVRKAGDDIQPGDVAVRQGSVL 163
Cdd:cd00887 68 VGEIPAGEPPDGPLGPGEAVRIMTGAPLPEGADAVVMVEDTEEEGGRVTITKPVKPGQNIRRAGEDIKAGDVLLPAGTRL 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 164 GPAQIGLLAASGRDKVLVYPRPRVTVMSFGLELVDIERDPGLGQVYDVASYAVAAAAKEAGATVTRAGIINAEPRRLKET 243
Cdd:cd00887 148 TPADIGLLASLGIAEVPVYRRPRVAIISTGDELVEPGEPLAPGQIYDSNSYMLAALLRELGAEVVDLGIVPDDPEALREA 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 244 IAHQASRSEMLIITGAVGGSGAEPVQNVLRDL-GEIDTTRVAMHPGSVQGFGLVGEerIPVFLLPPNTVSSLVIFEALIR 322
Cdd:cd00887 228 LEEALEEADVVITSGGVSVGDYDFVKEVLEELgGEVLFHGVAMKPGKPLAFGRLGG--KPVFGLPGNPVSALVTFELFVR 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 323 PTIRQSLGKAEPTRRTVQARSLGRIESLPGRLGLVRGRLMRDAetGDYLVQSLSGAEgapAHLLAGFAEANALIRIPRDI 402
Cdd:cd00887 306 PALRKLQGAPEPEPPRVKARLAEDLKSKPGRREFLRVRLERDE--GGLVVAPPGGQG---SGLLSSLARADGLIVIPEGV 380
|
410
....*....|....
gi 1939565266 403 TEVRPGDLVDVEFL 416
Cdd:cd00887 381 EGLEAGEEVEVLLL 394
|
|
| PRK14498 |
PRK14498 |
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing ... |
1-416 |
1.46e-62 |
|
putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional
Pssm-ID: 237732 [Multi-domain] Cd Length: 633 Bit Score: 212.77 E-value: 1.46e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 1 MRSVEDQLAIVVDA--APVPEPIRVGITDALGLMCAEEVSAANPLPGFPQAAVDGYAVRAVDVgggvalgSGPEKDRPVE 78
Cdd:PRK14498 9 LVSLEEAREILESLlsELPLGTEEVPLEEALGRVLAEDVYAPIDVPPFDRSAMDGYAVRAADT-------FGASEANPVR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 79 rsLPVVGEVAAGSQKPLRLQPKQAVRVATGAPLPTLADAVLPLQWSDR-GRKRVTPSRPVRTGDFVRKAGDDIQPGDVAV 157
Cdd:PRK14498 82 --LKLGGEVHAGEAPDVEVEPGEAVEIATGAPIPRGADAVVMVEDTEEvDDDTVEIYRPVAPGENVRPAGEDIVAGELIL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 158 RQGSVLGPAQIGLLAASGRDKVLVYPRPRVTVMSFGLELVDIERDPGLGQVYDVASYAVAAAAKEAGATVTRAGIINAEP 237
Cdd:PRK14498 160 PKGTRLTPRDIGALAAGGVAEVPVYKKPRVGIISTGDELVEPGEPLKPGKIYDVNSYTLAAAVEEAGGEPVRYGIVPDDE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 238 RRLKETIAHQASRSEMLIITGavGGS-GAEPV-QNVLRDLGEIDTTRVAMHPGSVQGFGLVGEEriPVFLLPPNTVSSLV 315
Cdd:PRK14498 240 EELEAALRKALKECDLVLLSG--GTSaGAGDVtYRVIEELGEVLVHGVAIKPGKPTILGVIGGK--PVVGLPGYPVSALT 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 316 IFEALIRPTIRQSLGKAEPTRRTVQARSLGRIESLPGRLGLVRGRLMRDAETgdYLVQSLSGAEGApahlLAGFAEANAL 395
Cdd:PRK14498 316 IFEEFVAPLLRKLAGLPPPERATVKARLARRVRSELGREEFVPVSLGRVGDG--YVAYPLSRGSGA----ITSLVRADGF 389
|
410 420
....*....|....*....|.
gi 1939565266 396 IRIPRDITEVRPGDLVDVEFL 416
Cdd:PRK14498 390 IEIPANTEGLEAGEEVEVELF 410
|
|
| PRK14491 |
PRK14491 |
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; ... |
3-419 |
9.01e-48 |
|
putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; Provisional
Pssm-ID: 237729 [Multi-domain] Cd Length: 597 Bit Score: 172.11 E-value: 9.01e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 3 SVEDQLAIVVDA-APVPEPIRVGITDALGLMCAEEVSAANPLPGFPQAAVDGYAVRavdvgggvalGSGPEKDrpverSL 81
Cdd:PRK14491 200 SVSQGLDKILSLvTPVTETEDVALDELDGRVLAQDVISPVNVPQHTNSAMDGYAFR----------SDDLEPE-----SY 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 82 PVVGEVAAGSQKPLRLQPKQAVRVATGAPLPTLADAVLPLQWSDRGRKRVTPSRPVRTGDFVRKAGDDIQPGDVAVRQGS 161
Cdd:PRK14491 265 TLVGEVLAGHQYDGTLQAGEAVRIMTGAPVPAGADTVVMRELATQDGDKVSFDGGIKAGQNVRLAGEDLAQGQVALAAGT 344
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 162 VLGPAQIGLLAASGRDKVLVYPRPRVTVMSFGLELvdieRDPGLGQ----VYDVASYAVAAAAKEAGATVTRAGIINAEP 237
Cdd:PRK14491 345 RLSAPEQGLLASLGFAEVPVFRRPKVAVFSTGDEV----QAPGETLkpncIYDSNRFTIKAMAKKLGCEVIDLGIIEDSE 420
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 238 RRLKETIAHQASRSEMLIITGAVGGSGAEPVQNVLRDLGEIDTTRVAMHPGSVQGFGLVGEEriPVFLLPPNTVSSLVIF 317
Cdd:PRK14491 421 AALEATLEQAAAQADVVISSGGVSVGDADYIKTALAKLGQIDFWRINMRPGRPLAFGQIGDS--PFFGLPGNPVAVMVSF 498
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 318 EALIRPTIRQSLGKAEPTRRTVQARSLGRIESLPGRLGLVRGrLMRDAETGDYLVQSlSGAEGapAHLLAGFAEANALIR 397
Cdd:PRK14491 499 LQFVEPALRKLAGEQNWQPLLFPAIADETLRSRQGRTEFSRG-IYHLGADGRLHVRT-TGKQG--SGILSSMSEANCLIE 574
|
410 420
....*....|....*....|..
gi 1939565266 398 IPRDITEVRPGDLVDVEFLQQR 419
Cdd:PRK14491 575 IGPAAETVNAGETVTIQPLAGL 596
|
|
| PLN02699 |
PLN02699 |
Bifunctional molybdopterin adenylyltransferase/molybdopterin molybdenumtransferase |
1-353 |
5.40e-44 |
|
Bifunctional molybdopterin adenylyltransferase/molybdopterin molybdenumtransferase
Pssm-ID: 215376 [Multi-domain] Cd Length: 659 Bit Score: 162.67 E-value: 5.40e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 1 MRSVEDQLAIVVDAAPVPEPIRVGITDALGLMCAEEVSAANPLPGFPQAAVDGYAVRAVDvgggvalgsGPEKdrpvers 80
Cdd:PLN02699 7 MISVEEALSIVLSVAARLSPVIVPLHEALGKVLAEDIRAPDPLPPYPASVKDGYAVVASD---------GPGE------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 81 LPVVGEVAAGSQ-KPLRLQPKQAVRVATGAPLPTLADAVLPLQWSDR------GRKRVTPSRPVRTGDFVRKAGDDIQPG 153
Cdd:PLN02699 71 YPVITESRAGNDgLGVTLTPGTVAYVTTGGPIPDGADAVVQVEDTEVvedpldGSKRVRILSQASKGQDIRPVGCDIEKD 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 154 DVAVRQGSVLGPAQIGLLAASGRDKVLVYPRPRVTVMSFGLELVD-IERDPGLGQVYDVASYAVAAAAKEAGATVTRAGI 232
Cdd:PLN02699 151 AKVLKAGERLGASEIGLLATVGVTMVKVYPRPTVAILSTGDELVEpTTGTLGRGQIRDSNRAMLLAAAIQQQCKVVDLGI 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 233 INAEPRRLKETIAHQASRS-EMLIITGAVGGSGAEPVQNVLRDLGEIDTTRVAMHPGSVQGFGLV-------GEERIPVF 304
Cdd:PLN02699 231 ARDDEEELERILDEAISSGvDILLTSGGVSMGDRDFVKPLLEKRGTVYFSKVLMKPGKPLTFAEIdaksapsNSKKMLAF 310
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1939565266 305 LLPPNTVSSLVIFEALIRPTIRQSLGKAEPTRRTVQARSLGRIESLPGR 353
Cdd:PLN02699 311 GLPGNPVSCLVCFNLFVVPAIRYLAGWSNPHLLRVQARLREPIKLDPVR 359
|
|
| PRK10680 |
PRK10680 |
molybdopterin biosynthesis protein MoeA; Provisional |
3-415 |
4.32e-43 |
|
molybdopterin biosynthesis protein MoeA; Provisional
Pssm-ID: 182643 [Multi-domain] Cd Length: 411 Bit Score: 155.64 E-value: 4.32e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 3 SVEDQLAIVVDAA-PVPEPIRVGITDALGLMCAEEVSAANPLPGFPQAAVDGYAVRAVDVGGGVALgsgpekdrpversl 81
Cdd:PRK10680 9 SLETALTEMLSRVtPLTATETLPLVQCFGRITASDIVSPLDVPGFDNSAMDGYAVRLADLASGQPL-------------- 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 82 PVVGEVAAGSQKPLRLQPKQAVRVATGAPLPTLADAVLPLQWSDRGRKRVTPSRPVRTGDFVRKAGDDIQPGDVAVRQGS 161
Cdd:PRK10680 75 PVAGKAFAGQPFHGEWPAGTCIRIMTGAPVPEGCEAVVMQEQTEQTDDGVRFTAEVRSGQNIRRRGEDISQGAVVFPAGT 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 162 VLGPAQIGLLAASGRDKVLVYPRPRVTVMSFGLELVDIERDPGLGQVYDVASYAVAAAAKEAGATVTRAGIINAEPRRLK 241
Cdd:PRK10680 155 RLTTAELPVLASLGIAEVPVVRKVRVALFSTGDELQLPGQPLGDGQIYDTNRLAVHLMLEQLGCEVINLGIIRDDPHALR 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 242 ETIAHQASRSEMLIITGAVGGSGAEPVQNVLRDLGEIDTTRVAMHPGSVQGFG------LVGeeripvflLPPNTVSSLV 315
Cdd:PRK10680 235 AAFIEADSQADVVISSGGVSVGEADYTKTILEELGEIAFWKLAIKPGKPFAFGklsnswFCG--------LPGNPVSAAL 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 316 IFEALIRPTIRQSLGK---AEPTRRTVQARSlgRIESLPGRLGLVRGRLMRDAEtGDYLVQSlSGAEGapAHLLAGFAEA 392
Cdd:PRK10680 307 TFYQLVQPLLAKLSGNtasGLPPRQRVRTAS--RLKKTPGRLDFQRGILQRNAD-GELEVTT-TGHQG--SHIFSSFSLG 380
|
410 420
....*....|....*....|...
gi 1939565266 393 NALIRIPRDITEVRPGDLVDVEF 415
Cdd:PRK10680 381 NCFIVLERERGNVEVGEWVEVEP 403
|
|
| PRK14497 |
PRK14497 |
putative molybdopterin biosynthesis protein MoeA/unknown domain fusion protein; Provisional |
3-349 |
2.20e-40 |
|
putative molybdopterin biosynthesis protein MoeA/unknown domain fusion protein; Provisional
Pssm-ID: 172968 [Multi-domain] Cd Length: 546 Bit Score: 151.11 E-value: 2.20e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 3 SVEDQLAIVVDA-APVPEPIRVGITDALGLMCAEEVSAANPLPGFPQAAVDGYAVRAVDVGGgvalgsgpekdrpverSL 81
Cdd:PRK14497 12 SIDEAIKVFLSSlNFKPKIVKVEVKDSFGYVSAEDLMSPIDYPPFSRSTVDGYALKSSCTPG----------------EF 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 82 PVVGEVAAGSQKPLRLQPKQAVRVATGAPLPTLADAVLPLQWSDRGR-KRVTPSRPVRTGDFVRKAGDDIQPGDVAVRQG 160
Cdd:PRK14497 76 KVIDKIGIGEFKEIHIKECEAVEVDTGSMIPMGADAVIKVENTKVINgNFIKIDKKINFGQNIGWIGSDIPKGSIILRKG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 161 SVLGPAQIGLLAASGRDKVLVYPRPRVTVMSFGLELVDIERDPGLGQVYDVASYAVAAAAKEAGATVTRAGIINAEPRRL 240
Cdd:PRK14497 156 EVISHEKIGLLASLGISSVKVYEKPKIYLIATGDELVEPGNSLSPGKIYESNLHYLYSKLKSEGYKIVGLSLLSDDKESI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 241 KETIAHQASRSEMLIITGAVGGSGAEPVQNVLRDLGEIDTTRVAMHPGSVQGFGLVGEEriPVFLLPPNTVSSLVIFEAL 320
Cdd:PRK14497 236 KNEIKRAISVADVLILTGGTSAGEKDFVHQAIRELGNIIVHGLKIKPGKPTILGIVDGK--PVIGLPGNIVSTMVVLNMV 313
|
330 340 350
....*....|....*....|....*....|.
gi 1939565266 321 IRPTIRQ--SLGKAEPTRRTVQARSLGRIES 349
Cdd:PRK14497 314 ILEYLKSlyPSRKEILGLGKIKARLALRVKA 344
|
|
| MoeA_N |
pfam03453 |
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of ... |
16-175 |
2.33e-35 |
|
MoeA N-terminal region (domain I and II); This family contains two structural domains. One of these contains the conserved DGXA motif. This region is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this region is uncertain.
Pssm-ID: 460923 [Multi-domain] Cd Length: 147 Bit Score: 127.30 E-value: 2.33e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 16 PVPEPIRVGITDALGLMCAEEVSAANPLPGFPQAAVDGYAVRAVDvgggvalGSGPEKDRPVerslpvvgevAAGSQKPL 95
Cdd:pfam03453 4 GTEETVPLEALDALGRVLAEDVVAPRDVPPFDRSAMDGYAVRAAD-------GFGASEVNPI----------AAGEPPGP 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 96 RLQPKQAVRVATGAPLPTLADAVLPLQW-SDRGRKRVTPSRPVRTGDFVRKAGDDIQPGDVAVRQGSVLGPAQIGLLAAS 174
Cdd:pfam03453 67 LLPGGEAVRIMTGAPLPEGADAVVMVEDtEEGGGRTVEIRAPVAPGENVRRAGEDIKAGEVVLPAGTRLTPAEIGLLASL 146
|
.
gi 1939565266 175 G 175
Cdd:pfam03453 147 G 147
|
|
| PRK14690 |
PRK14690 |
molybdopterin biosynthesis protein MoeA; Provisional |
15-411 |
4.53e-29 |
|
molybdopterin biosynthesis protein MoeA; Provisional
Pssm-ID: 237789 [Multi-domain] Cd Length: 419 Bit Score: 117.33 E-value: 4.53e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 15 APVPEPIRVGITDALGLMCAEEVSAANPLPGFPQAAVDGYAVravdvGGGVALGSgpekdrpveRSLPVV-GEVAAGSQK 93
Cdd:PRK14690 37 GPVTDIKELDLSDALGHVLAHDAVALRSNPPQANSAVDGYGF-----AGAAPEGA---------QVLPLIeGRAAAGVPF 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 94 PLRLQPKQAVRVATGAPLPTLADAVLPLQWSDRGRKRVTPSRPVRTGDFVRKAGDDIQPGDVAVRQGSVLGPAQIGLLAA 173
Cdd:PRK14690 103 SGRVPEGMALRILTGAALPEGVDTVVLEEDVAGDGHRIAFHGPLKMGANTRKAGEDVIAGDVALPAGRRLTPADLALLSA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 174 SGRDKVLVYPRPRVTVMSFGLELVDIERDPGLGQVYDVASYAVAAAAKEAGATVTRAGIINAEPRRLKETIAHQASRSEM 253
Cdd:PRK14690 183 VGLTRVSVRRPLRVAVLSTGDELVEPGALAEVGQIYDANRPMLLALARRWGHAPVDLGRVGDDRAALAARLDRAAAEADV 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 254 LIITGAVGGSGAEPVQNVLRDLGEIDTTRVAMHPGSVQGFGLvgEERIPVFLLPPNTVSSLVIFEALIRPTIRQSLGK-- 331
Cdd:PRK14690 263 ILTSGGASAGDEDHVSALLREAGAMQSWRIALKPGRPLALGL--WQGVPVFGLPGNPVAALVCTLVFARPAMSLLAGEgw 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 332 AEPTRRTVQA-----RSLGRIESLPGRLGLVRGRLMRDAETGDylVQSLSGAEGapahllagfaeanaLIRIPRDITEVR 406
Cdd:PRK14690 341 SEPQGFTVPAafekrKKPGRREYLRARLRQGHAEVFRSEGSGR--ISGLSWAEG--------------LVELGDGARRIA 404
|
....*
gi 1939565266 407 PGDLV 411
Cdd:PRK14690 405 PGDPV 409
|
|
| molyb_syn |
TIGR00177 |
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein ... |
185-323 |
3.79e-15 |
|
molybdenum cofactor synthesis domain; The Drosophila protein cinnamon, the Arabidopsis protein cnx1, and rat protein gephyrin each have one domain like MoeA and one like MoaB and Mog. These domains are, however, distantly related to each other, as captured by this model. Gephyrin is unusual in that it seems to be a tubulin-binding neuroprotein involved in the clustering of both blycine receptors and GABA receptors, rather than a protein of molybdenum cofactor biosynthesis.
Pssm-ID: 272944 [Multi-domain] Cd Length: 148 Bit Score: 72.35 E-value: 3.79e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 185 PRVTVMSFGLELVDIERDPGLGQVYDVASYAVAAAAKEAGATVTRAGIINAEPRRLKETIAHQASRSEMLIITGAVGGSG 264
Cdd:TIGR00177 1 PRVAVISVGDELVEGGQPLEPGQIYDSNGPLLAALLQEAGFNVVRLGIVPDDPEEIREILRKAVDEADVVLTTGGTGVGP 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 265 AEPVQNVLRDLGEI-----------DTTRVAMHPGSVQGFGLVGeeRIPVFLLPPNTVSSLVIFEALIRP 323
Cdd:TIGR00177 81 RDVTPEALEELGEKeipgfgefrmlSSLPVLSRPGKPATAGVRG--GTLIFNLPGNPVSALVTFEVLILP 148
|
|
| MoeA_C |
pfam03454 |
MoeA C-terminal region (domain IV); This domain is found in proteins involved in biosynthesis ... |
340-416 |
1.41e-08 |
|
MoeA C-terminal region (domain IV); This domain is found in proteins involved in biosynthesis of molybdopterin cofactor however the exact molecular function of this domain is uncertain. The structure of this domain is known and forms an incomplete beta barrel.
Pssm-ID: 460924 [Multi-domain] Cd Length: 72 Bit Score: 51.07 E-value: 1.41e-08
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1939565266 340 QARSLGRIESLPGRLGLVRGRLMRDAetGDYLVQSLSGAEgapAHLLAGFAEANALIRIPRDITEVRPGDLVDVEFL 416
Cdd:pfam03454 1 KARLARDLKSDPGRREFVRVRLHEED--GRYYAEPIGKQG---SGMLSSLAEANGLIVVPEGTEGLEAGEEVEVILL 72
|
|
| MoCF_biosynth |
pfam00994 |
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in ... |
205-327 |
1.29e-06 |
|
Probable molybdopterin binding domain; This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerization.
Pssm-ID: 425979 [Multi-domain] Cd Length: 143 Bit Score: 47.63 E-value: 1.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1939565266 205 LGQVYDVASYAVAAAAKEAGATVTRAGIINAEPRRLKETIAHQASRSEMLIITGAVGGSGAEPVQNVLRDLGEIDTT--- 281
Cdd:pfam00994 11 PGQIRDTNGPLLAALLREAGAEVIRYGIVPDDPEAIKEALRAAAEEADVVITTGGTGPGPDDVTPEALAELGGRELPgfe 90
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1939565266 282 ----RVAMHPGSVQGFG---LVGEERIPVFLLPPNTVSSLVIFEALIRPTIRQ 327
Cdd:pfam00994 91 elfrGVSLKPGKPVGTApgaILSRAGKTVFGLPGSPVAAKVMFELLLLPLLRH 143
|
|
| |
