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hypothetical protein SADUNF_Sadunf09G0108800 [Salix dunnii]
List of domain hits
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Name | Accession | Description | Interval | E-value | ||||||
VWA_26S_proteasome_subunit | cd01452 | 26S proteasome plays a major role in eukaryotic protein breakdown, especially for ... |
631-816 | 1.54e-104 | ||||||
26S proteasome plays a major role in eukaryotic protein breakdown, especially for ubiquitin-tagged proteins. It is an ATP-dependent protease responsible for the bulk of non-lysosomal proteolysis in eukaryotes, often using covalent modification of proteins by ubiquitylation. It consists of a 20S proteolytic core particle (CP) and a 19S regulatory particle (RP). The CP is an ATP independent peptidase consisting of hydrolyzing activities. One or both ends of CP carry the RP that confers both ubiquitin and ATP dependence to the 26S proteosome. The RP's proposed functions include recognition of substrates and translocation of these to CP for proteolysis. The RP can dissociate into a stable lid and base subcomplexes. The base is composed of three non-ATPase subunits (Rpn 1, 2 and 10). A single residue in the vWA domain of Rpn10 has been implicated to be responsible for stabilizing the lid-base association. : Pssm-ID: 238729 Cd Length: 187 Bit Score: 328.17 E-value: 1.54e-104
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PLN03216 | PLN03216 | actin depolymerizing factor; Provisional |
1130-1265 | 6.51e-97 | ||||||
actin depolymerizing factor; Provisional : Pssm-ID: 178755 Cd Length: 141 Bit Score: 305.31 E-value: 6.51e-97
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Choline_transpo | pfam04515 | Plasma-membrane choline transporter; This family represents a high-affinity plasma-membrane ... |
206-529 | 2.23e-72 | ||||||
Plasma-membrane choline transporter; This family represents a high-affinity plasma-membrane choline transporter in C.elegans which is thought to be rate-limiting for ACh synthesis in cholinergic nerve terminals. : Pssm-ID: 461337 Cd Length: 325 Bit Score: 244.41 E-value: 2.23e-72
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PSMD4_RAZUL | cd22297 | RAZUL (Rpn10 AZUL-binding) domain of 26S proteasome non-ATPase regulatory subunit 4 (PSMD4) ... |
968-1015 | 1.42e-15 | ||||||
RAZUL (Rpn10 AZUL-binding) domain of 26S proteasome non-ATPase regulatory subunit 4 (PSMD4) and similar proteins; PSMD4 is also called 26S proteasome regulatory subunit RPN10, 26S proteasome regulatory subunit S5A, antisecretory factor 1, AF, ASF, or multiubiquitin chain-binding protein (MCB1). It acts as a ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. It displays a preferred selectivity for longer polyubiquitin chains. PSMD4 is a component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. The proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The model corresponds to the C-terminal Rpn10 AZUL-binding domain (RAZUL) of PSMD4, which is responsible for binding the AZUL domain of E6AP/UBE3A. AZUL stands for amino-terminal zinc-binding domain of ubiquitin E3a ligase. : Pssm-ID: 412092 Cd Length: 48 Bit Score: 71.83 E-value: 1.42e-15
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Voltage_CLC super family | cl28978 | Voltage gated chloride channel; This family of ion channels contains 10 or 12 transmembrane ... |
120-219 | 4.32e-04 | ||||||
Voltage gated chloride channel; This family of ion channels contains 10 or 12 transmembrane helices. Each protein forms a single pore. It has been shown that some members of this family form homodimers. In terms of primary structure, they are unrelated to known cation channels or other types of anion channels. Three ClC subfamilies are found in animals. ClC-1 is involved in setting and restoring the resting membrane potential of skeletal muscle, while other channels play important parts in solute concentration mechanisms in the kidney. These proteins contain two pfam00571 domains. The actual alignment was detected with superfamily member pfam00654: Pssm-ID: 425802 [Multi-domain] Cd Length: 344 Bit Score: 44.08 E-value: 4.32e-04
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Name | Accession | Description | Interval | E-value | ||||||
VWA_26S_proteasome_subunit | cd01452 | 26S proteasome plays a major role in eukaryotic protein breakdown, especially for ... |
631-816 | 1.54e-104 | ||||||
26S proteasome plays a major role in eukaryotic protein breakdown, especially for ubiquitin-tagged proteins. It is an ATP-dependent protease responsible for the bulk of non-lysosomal proteolysis in eukaryotes, often using covalent modification of proteins by ubiquitylation. It consists of a 20S proteolytic core particle (CP) and a 19S regulatory particle (RP). The CP is an ATP independent peptidase consisting of hydrolyzing activities. One or both ends of CP carry the RP that confers both ubiquitin and ATP dependence to the 26S proteosome. The RP's proposed functions include recognition of substrates and translocation of these to CP for proteolysis. The RP can dissociate into a stable lid and base subcomplexes. The base is composed of three non-ATPase subunits (Rpn 1, 2 and 10). A single residue in the vWA domain of Rpn10 has been implicated to be responsible for stabilizing the lid-base association. Pssm-ID: 238729 Cd Length: 187 Bit Score: 328.17 E-value: 1.54e-104
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PLN03216 | PLN03216 | actin depolymerizing factor; Provisional |
1130-1265 | 6.51e-97 | ||||||
actin depolymerizing factor; Provisional Pssm-ID: 178755 Cd Length: 141 Bit Score: 305.31 E-value: 6.51e-97
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Choline_transpo | pfam04515 | Plasma-membrane choline transporter; This family represents a high-affinity plasma-membrane ... |
206-529 | 2.23e-72 | ||||||
Plasma-membrane choline transporter; This family represents a high-affinity plasma-membrane choline transporter in C.elegans which is thought to be rate-limiting for ACh synthesis in cholinergic nerve terminals. Pssm-ID: 461337 Cd Length: 325 Bit Score: 244.41 E-value: 2.23e-72
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ADF_cofilin_like | cd11286 | Cofilin, Destrin, and related actin depolymerizing factors; Actin depolymerization factor ... |
1132-1264 | 4.22e-56 | ||||||
Cofilin, Destrin, and related actin depolymerizing factors; Actin depolymerization factor/cofilin-like domains (ADF domains) are present in a family of essential eukaryotic actin regulatory proteins. These proteins enhance the turnover rate of actin, and interact with actin monomers (G-actin) as well as actin filaments (F-actin), typically with a preference for ADP-G-actin subunits. The basic function of cofilin is to promote disassembly of aged actin filaments. Vertebrates have three isoforms of cofilin: cofilin-1 (Cfl1, non-muscle cofilin), cofilin-2 (muscle cofilin), and ADF (destrin). When bound to actin monomers, cofilins inhibit their spontaneous exchange of nucleotides. The cooperative binding to (aged) ADP-F-actin induces a local change in the actin filament structure and further promotes aging. Pssm-ID: 200442 Cd Length: 133 Bit Score: 190.46 E-value: 4.22e-56
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ADF | smart00102 | Actin depolymerisation factor/cofilin -like domains; Severs actin filaments and binds to actin ... |
1138-1265 | 1.12e-45 | ||||||
Actin depolymerisation factor/cofilin -like domains; Severs actin filaments and binds to actin monomers. Pssm-ID: 214516 Cd Length: 127 Bit Score: 160.53 E-value: 1.12e-45
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Cofilin_ADF | pfam00241 | Cofilin/tropomyosin-type actin-binding protein; Severs actin filaments and binds to actin ... |
1140-1262 | 2.04e-41 | ||||||
Cofilin/tropomyosin-type actin-binding protein; Severs actin filaments and binds to actin monomers. Pssm-ID: 459727 Cd Length: 123 Bit Score: 148.11 E-value: 2.04e-41
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VWA_2 | pfam13519 | von Willebrand factor type A domain; |
634-741 | 5.33e-29 | ||||||
von Willebrand factor type A domain; Pssm-ID: 463909 [Multi-domain] Cd Length: 103 Bit Score: 112.00 E-value: 5.33e-29
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PSMD4_RAZUL | cd22297 | RAZUL (Rpn10 AZUL-binding) domain of 26S proteasome non-ATPase regulatory subunit 4 (PSMD4) ... |
968-1015 | 1.42e-15 | ||||||
RAZUL (Rpn10 AZUL-binding) domain of 26S proteasome non-ATPase regulatory subunit 4 (PSMD4) and similar proteins; PSMD4 is also called 26S proteasome regulatory subunit RPN10, 26S proteasome regulatory subunit S5A, antisecretory factor 1, AF, ASF, or multiubiquitin chain-binding protein (MCB1). It acts as a ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. It displays a preferred selectivity for longer polyubiquitin chains. PSMD4 is a component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. The proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The model corresponds to the C-terminal Rpn10 AZUL-binding domain (RAZUL) of PSMD4, which is responsible for binding the AZUL domain of E6AP/UBE3A. AZUL stands for amino-terminal zinc-binding domain of ubiquitin E3a ligase. Pssm-ID: 412092 Cd Length: 48 Bit Score: 71.83 E-value: 1.42e-15
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VWA | smart00327 | von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins ... |
635-802 | 5.29e-15 | ||||||
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods. Pssm-ID: 214621 [Multi-domain] Cd Length: 175 Bit Score: 74.41 E-value: 5.29e-15
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ChlD | COG1240 | vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and ... |
635-776 | 6.04e-07 | ||||||
vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and metabolism]; Pssm-ID: 440853 [Multi-domain] Cd Length: 262 Bit Score: 52.25 E-value: 6.04e-07
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Voltage_CLC | pfam00654 | Voltage gated chloride channel; This family of ion channels contains 10 or 12 transmembrane ... |
120-219 | 4.32e-04 | ||||||
Voltage gated chloride channel; This family of ion channels contains 10 or 12 transmembrane helices. Each protein forms a single pore. It has been shown that some members of this family form homodimers. In terms of primary structure, they are unrelated to known cation channels or other types of anion channels. Three ClC subfamilies are found in animals. ClC-1 is involved in setting and restoring the resting membrane potential of skeletal muscle, while other channels play important parts in solute concentration mechanisms in the kidney. These proteins contain two pfam00571 domains. Pssm-ID: 425802 [Multi-domain] Cd Length: 344 Bit Score: 44.08 E-value: 4.32e-04
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7tmA_EDG-like | cd14972 | endothelial differentiation gene family, member of the class A family of seven-transmembrane G ... |
118-269 | 6.07e-03 | ||||||
endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system. Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 39.97 E-value: 6.07e-03
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Name | Accession | Description | Interval | E-value | ||||||
VWA_26S_proteasome_subunit | cd01452 | 26S proteasome plays a major role in eukaryotic protein breakdown, especially for ... |
631-816 | 1.54e-104 | ||||||
26S proteasome plays a major role in eukaryotic protein breakdown, especially for ubiquitin-tagged proteins. It is an ATP-dependent protease responsible for the bulk of non-lysosomal proteolysis in eukaryotes, often using covalent modification of proteins by ubiquitylation. It consists of a 20S proteolytic core particle (CP) and a 19S regulatory particle (RP). The CP is an ATP independent peptidase consisting of hydrolyzing activities. One or both ends of CP carry the RP that confers both ubiquitin and ATP dependence to the 26S proteosome. The RP's proposed functions include recognition of substrates and translocation of these to CP for proteolysis. The RP can dissociate into a stable lid and base subcomplexes. The base is composed of three non-ATPase subunits (Rpn 1, 2 and 10). A single residue in the vWA domain of Rpn10 has been implicated to be responsible for stabilizing the lid-base association. Pssm-ID: 238729 Cd Length: 187 Bit Score: 328.17 E-value: 1.54e-104
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PLN03216 | PLN03216 | actin depolymerizing factor; Provisional |
1130-1265 | 6.51e-97 | ||||||
actin depolymerizing factor; Provisional Pssm-ID: 178755 Cd Length: 141 Bit Score: 305.31 E-value: 6.51e-97
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Choline_transpo | pfam04515 | Plasma-membrane choline transporter; This family represents a high-affinity plasma-membrane ... |
206-529 | 2.23e-72 | ||||||
Plasma-membrane choline transporter; This family represents a high-affinity plasma-membrane choline transporter in C.elegans which is thought to be rate-limiting for ACh synthesis in cholinergic nerve terminals. Pssm-ID: 461337 Cd Length: 325 Bit Score: 244.41 E-value: 2.23e-72
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ADF_cofilin_like | cd11286 | Cofilin, Destrin, and related actin depolymerizing factors; Actin depolymerization factor ... |
1132-1264 | 4.22e-56 | ||||||
Cofilin, Destrin, and related actin depolymerizing factors; Actin depolymerization factor/cofilin-like domains (ADF domains) are present in a family of essential eukaryotic actin regulatory proteins. These proteins enhance the turnover rate of actin, and interact with actin monomers (G-actin) as well as actin filaments (F-actin), typically with a preference for ADP-G-actin subunits. The basic function of cofilin is to promote disassembly of aged actin filaments. Vertebrates have three isoforms of cofilin: cofilin-1 (Cfl1, non-muscle cofilin), cofilin-2 (muscle cofilin), and ADF (destrin). When bound to actin monomers, cofilins inhibit their spontaneous exchange of nucleotides. The cooperative binding to (aged) ADP-F-actin induces a local change in the actin filament structure and further promotes aging. Pssm-ID: 200442 Cd Length: 133 Bit Score: 190.46 E-value: 4.22e-56
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ADF | smart00102 | Actin depolymerisation factor/cofilin -like domains; Severs actin filaments and binds to actin ... |
1138-1265 | 1.12e-45 | ||||||
Actin depolymerisation factor/cofilin -like domains; Severs actin filaments and binds to actin monomers. Pssm-ID: 214516 Cd Length: 127 Bit Score: 160.53 E-value: 1.12e-45
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Cofilin_ADF | pfam00241 | Cofilin/tropomyosin-type actin-binding protein; Severs actin filaments and binds to actin ... |
1140-1262 | 2.04e-41 | ||||||
Cofilin/tropomyosin-type actin-binding protein; Severs actin filaments and binds to actin monomers. Pssm-ID: 459727 Cd Length: 123 Bit Score: 148.11 E-value: 2.04e-41
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VWA_2 | pfam13519 | von Willebrand factor type A domain; |
634-741 | 5.33e-29 | ||||||
von Willebrand factor type A domain; Pssm-ID: 463909 [Multi-domain] Cd Length: 103 Bit Score: 112.00 E-value: 5.33e-29
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ADF_gelsolin | cd00013 | Actin depolymerization factor/cofilin- and gelsolin-like domains; Actin depolymerization ... |
1154-1251 | 1.57e-19 | ||||||
Actin depolymerization factor/cofilin- and gelsolin-like domains; Actin depolymerization factor/cofilin-like domains are present in a family of essential eukaryotic actin regulatory proteins; these proteins enhance the turnover rate of actin and interact with actin monomers as well as actin filaments. Pssm-ID: 200435 Cd Length: 97 Bit Score: 84.82 E-value: 1.57e-19
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PSMD4_RAZUL | cd22297 | RAZUL (Rpn10 AZUL-binding) domain of 26S proteasome non-ATPase regulatory subunit 4 (PSMD4) ... |
968-1015 | 1.42e-15 | ||||||
RAZUL (Rpn10 AZUL-binding) domain of 26S proteasome non-ATPase regulatory subunit 4 (PSMD4) and similar proteins; PSMD4 is also called 26S proteasome regulatory subunit RPN10, 26S proteasome regulatory subunit S5A, antisecretory factor 1, AF, ASF, or multiubiquitin chain-binding protein (MCB1). It acts as a ubiquitin receptor subunit through ubiquitin-interacting motifs and selects ubiquitin-conjugates for destruction. It displays a preferred selectivity for longer polyubiquitin chains. PSMD4 is a component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. The proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The model corresponds to the C-terminal Rpn10 AZUL-binding domain (RAZUL) of PSMD4, which is responsible for binding the AZUL domain of E6AP/UBE3A. AZUL stands for amino-terminal zinc-binding domain of ubiquitin E3a ligase. Pssm-ID: 412092 Cd Length: 48 Bit Score: 71.83 E-value: 1.42e-15
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VWA | smart00327 | von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins ... |
635-802 | 5.29e-15 | ||||||
von Willebrand factor (vWF) type A domain; VWA domains in extracellular eukaryotic proteins mediate adhesion via metal ion-dependent adhesion sites (MIDAS). Intracellular VWA domains and homologues in prokaryotes have recently been identified. The proposed VWA domains in integrin beta subunits have recently been substantiated using sequence-based methods. Pssm-ID: 214621 [Multi-domain] Cd Length: 175 Bit Score: 74.41 E-value: 5.29e-15
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PTZ00152 | PTZ00152 | cofilin/actin-depolymerizing factor 1-like protein; Provisional |
1132-1243 | 1.81e-14 | ||||||
cofilin/actin-depolymerizing factor 1-like protein; Provisional Pssm-ID: 173441 Cd Length: 122 Bit Score: 71.14 E-value: 1.81e-14
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ADF_Twf-C_like | cd11284 | C-terminal ADF domain of twinfilin and related proteins; Actin depolymerization factor ... |
1136-1262 | 4.23e-11 | ||||||
C-terminal ADF domain of twinfilin and related proteins; Actin depolymerization factor/cofilin-like domains (ADF domains) are present in a family of essential eukaryotic actin regulatory proteins. Twinfilin contains two ADF domains, and inhibits the assembly of actin filaments by strongly interacting with monomeric ADP-actin (ADP-G-actin) in a 1:1 stochiometry (with it's C-terminal ADF domain, Twf-C) and inhibiting the actin monomer's nucleotide exchange. Mammalian twinfilin may also cap the barbed ends of F-actin filaments and prevent further assembly (or disassembly), in a process which requires both ADF domains. The N-terminal ADF domain (Twf-N) binds G-actin with a lower affinity than Twf-C; Twf-C can also bind F-actin. During capping, Twf-N may interact with the terminal actin subunit, and Twf-C may bind between two adjacent subunits at the side of the filament. Pssm-ID: 200440 Cd Length: 132 Bit Score: 61.86 E-value: 4.23e-11
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ADF_GMF-beta_like | cd11283 | ADF-homology domain of glia maturation factor beta and related proteins; Actin ... |
1136-1241 | 2.69e-10 | ||||||
ADF-homology domain of glia maturation factor beta and related proteins; Actin depolymerization factor/cofilin-like domains (ADF domains) are present in a family of essential eukaryotic actin regulatory proteins. Most of these proteins enhance the turnover rate of actin and interact with actin monomers as well as actin filaments. The glia maturation factor (GMF), however, does not bind actin but interacts with the Arp2/3 complex (which contains actin-related proteins, amongst others) and suppresses Arp2/3 activity, inducing the dissociation of branched daughter filaments from their mother filaments. This family includes both mammalian GMF isoforms, GMF-beta and GMF-gamma. GMF-beta regulates cellular growth, fission, differentiation and apoptosis. GMF-gamma is important in myeloid cell development and is an important regulator for cell migration and polarity in neutrophils. Pssm-ID: 200439 [Multi-domain] Cd Length: 122 Bit Score: 59.17 E-value: 2.69e-10
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ADF_Twf-N_like | cd11285 | N-terminal ADF domain of twinfilin and related proteins; Actin depolymerization factor ... |
1132-1255 | 2.98e-07 | ||||||
N-terminal ADF domain of twinfilin and related proteins; Actin depolymerization factor/cofilin-like domains (ADF domains) are present in a family of essential eukaryotic actin regulatory proteins. Twinfilin contains two ADF domains, and inhibits the assembly of actin filaments by strongly interacting with monomeric ADP-actin (ADP-G-actin) in a 1:1 stochiometry (with it's C-terminal ADF domain, Twf-C) and inhibiting the actin monomer's nucleotide exchange. Mammalian twinfilin may also cap the barbed ends of F-actin filaments and prevent further assembly (or disassembly), in a process which requires both ADF domains. The N-terminal ADF domain (Twf-N) binds G-actin with a lower affinity than Twf-C; Twf-C can also bind F-actin. During capping, Twf-N may interact with the terminal actin subunit, and Twf-C may bind between two adjacent subunits at the side of the filament. Pssm-ID: 200441 Cd Length: 139 Bit Score: 51.09 E-value: 2.98e-07
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ChlD | COG1240 | vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and ... |
635-776 | 6.04e-07 | ||||||
vWFA (von Willebrand factor type A) domain of Mg and Co chelatases [Coenzyme transport and metabolism]; Pssm-ID: 440853 [Multi-domain] Cd Length: 262 Bit Score: 52.25 E-value: 6.04e-07
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vWFA | cd00198 | Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ... |
635-786 | 1.60e-06 | ||||||
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Pssm-ID: 238119 [Multi-domain] Cd Length: 161 Bit Score: 49.49 E-value: 1.60e-06
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vWA_transcription_factor_IIH_type | cd01453 | Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five ... |
635-765 | 1.12e-05 | ||||||
Transcription factors IIH type: TFIIH is a multiprotein complex that is one of the five general transcription factors that binds RNA polymerase II holoenzyme. Orthologues of these genes are found in all completed eukaryotic genomes and all these proteins contain a VWA domain. The p44 subunit of TFIIH functions as a DNA helicase in RNA polymerase II transcription initiation and DNA repair, and its transcriptional activity is dependent on its C-terminal Zn-binding domains. The function of the vWA domain is unclear, but may be involved in complex assembly. The MIDAS motif is not conserved in this sub-group. Pssm-ID: 238730 Cd Length: 183 Bit Score: 47.33 E-value: 1.12e-05
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vWA_subgroup | cd01465 | VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood ... |
672-793 | 2.36e-05 | ||||||
VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains. Not much is known about the function of the VWA domain in these proteins. The members do have a conserved MIDAS motif. The biochemical function however is not known. Pssm-ID: 238742 [Multi-domain] Cd Length: 170 Bit Score: 46.11 E-value: 2.36e-05
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Voltage_CLC | pfam00654 | Voltage gated chloride channel; This family of ion channels contains 10 or 12 transmembrane ... |
120-219 | 4.32e-04 | ||||||
Voltage gated chloride channel; This family of ion channels contains 10 or 12 transmembrane helices. Each protein forms a single pore. It has been shown that some members of this family form homodimers. In terms of primary structure, they are unrelated to known cation channels or other types of anion channels. Three ClC subfamilies are found in animals. ClC-1 is involved in setting and restoring the resting membrane potential of skeletal muscle, while other channels play important parts in solute concentration mechanisms in the kidney. These proteins contain two pfam00571 domains. Pssm-ID: 425802 [Multi-domain] Cd Length: 344 Bit Score: 44.08 E-value: 4.32e-04
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7tmA_EDG-like | cd14972 | endothelial differentiation gene family, member of the class A family of seven-transmembrane G ... |
118-269 | 6.07e-03 | ||||||
endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system. Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 39.97 E-value: 6.07e-03
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Blast search parameters | ||||
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