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Conserved domains on  [gi|1938978927|gb|QPK53235|]
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glycosyltransferase family 2 protein [Paenibacillus polymyxa]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 10135509)

glycosyltransferase family 2 protein catalyzes the transfer of saccharide moieties from a donor to an acceptor to form glycosidic bonds

CAZY:  GT2
EC:  2.4.-.-
Gene Ontology:  GO:0016757
PubMed:  9445404|12691742
SCOP:  3000077

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 5-226 1.81e-68

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


:

Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 210.49  E-value: 1.81e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927   5 ILVVNYNTCRLTLDCLQSVYAsKTQYRYEVIVIDNHSSDGSVEAIRAAYPEIMLIANQDNTGFAKANNQGMEVASGRYVL 84
Cdd:cd04186     1 IIIVNYNSLEYLKACLDSLLA-QTYPDFEVIVVDNASTDGSVELLRELFPEVRLIRNGENLGFGAGNNQGIREAKGDYVL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927  85 LLNSDTLVQPDTLDTMIRFMDTHPEMGASGCKVIlpdgsldkackrgfptpsasfyyafgwskrypdnpkynqyqlghls 164
Cdd:cd04186    80 LLNPDTVVEPGALLELLDAAEQDPDVGIVGPKVS---------------------------------------------- 113

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1938978927 165 pddeypvdvlvGAFMLVRRETIDQVGGLDETFFMYGEDIDWCYRIKQAGWGIYYYPHTYIIH 226
Cdd:cd04186   114 -----------GAFLLVRREVFEEVGGFDEDFFLYYEDVDLCLRARLAGYRVLYVPQAVIYH 164
 
Name Accession Description Interval E-value
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 5-226 1.81e-68

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 210.49  E-value: 1.81e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927   5 ILVVNYNTCRLTLDCLQSVYAsKTQYRYEVIVIDNHSSDGSVEAIRAAYPEIMLIANQDNTGFAKANNQGMEVASGRYVL 84
Cdd:cd04186     1 IIIVNYNSLEYLKACLDSLLA-QTYPDFEVIVVDNASTDGSVELLRELFPEVRLIRNGENLGFGAGNNQGIREAKGDYVL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927  85 LLNSDTLVQPDTLDTMIRFMDTHPEMGASGCKVIlpdgsldkackrgfptpsasfyyafgwskrypdnpkynqyqlghls 164
Cdd:cd04186    80 LLNPDTVVEPGALLELLDAAEQDPDVGIVGPKVS---------------------------------------------- 113

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1938978927 165 pddeypvdvlvGAFMLVRRETIDQVGGLDETFFMYGEDIDWCYRIKQAGWGIYYYPHTYIIH 226
Cdd:cd04186   114 -----------GAFLLVRREVFEEVGGFDEDFFLYYEDVDLCLRARLAGYRVLYVPQAVIYH 164
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
1-262 4.17e-64

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 200.60  E-value: 4.17e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927   1 MDVSILVVNYNTCRLTLDCLQSVYASkTQYRYEVIVIDNHSSDGSVEAIRA-AYPEIMLIANQDNTGFAKANNQGMEVAS 79
Cdd:COG1216     3 PKVSVVIPTYNRPELLRRCLESLLAQ-TYPPFEVIVVDNGSTDGTAELLAAlAFPRVRVIRNPENLGFAAARNLGLRAAG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927  80 GRYVLLLNSDTLVQPDTLDTMIRFmdthpemgasgckvilpdgsldkackrgfptpsasfyyafgwskrypdnpkynqyq 159
Cdd:COG1216    82 GDYLLFLDDDTVVEPDWLERLLAA-------------------------------------------------------- 105

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927 160 lghlspddeypvdvlvgAFMLVRRETIDQVGGLDETFFMYGEDIDWCYRIKQAGWGIYYYPHTYIIHIKGGSarRRPLKI 239
Cdd:COG1216   106 -----------------ACLLIRREVFEEVGGFDERFFLYGEDVDLCLRLRKAGYRIVYVPDAVVYHLGGAS--SGPLLR 166

                         250       260
                  ....*....|....*....|...
gi 1938978927 240 IYEFHRAMWVFHRKHYKQQYSWF 262
Cdd:COG1216   167 AYYLGRNRLLFLRKHGPRPLLRL 189
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 4-114 4.56e-20

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 85.14  E-value: 4.56e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927   4 SILVVNYNTCRLTLDCLQSVyASKTQYRYEVIVIDNHSSDGSVEAIRAA---YPEIMLIANQDNTGFAKANNQGMEVASG 80
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESL-LNQTYPNFEIIVVDDGSTDGTVEIAEEYakkDPRVRVIRLPENRGKAGARNAGLRAATG 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1938978927  81 RYVLLLNSDTLVQPDTLDTMIRFMDTHPEMGASG 114
Cdd:pfam00535  80 DYIAFLDADDEVPPDWLEKLVEALEEDGADVVVG 113
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 3-101 1.85e-11

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 63.53  E-value: 1.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927   3 VSILVVNYNTCRLTLDCLQSVYAsKTQYRYEVIVIDNHSSDGSVEAI---RAAYPEIMLIAnQDNTGFAKANNQGMEVAS 79
Cdd:PRK10073    8 LSIIIPLYNAGKDFRAFMESLIA-QTWTALEIIIVNDGSTDNSVEIAkhyAENYPHVRLLH-QANAGVSVARNTGLAVAT 85

                          90       100
                  ....*....|....*....|..
gi 1938978927  80 GRYVLLLNSDTLVQPDTLDTMI 101
Cdd:PRK10073   86 GKYVAFPDADDVVYPTMYETLM 107
EPS_HpsE NF038302
hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;
17-227 9.32e-07

hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;


Pssm-ID: 439602 [Multi-domain]  Cd Length: 307  Bit Score: 49.41  E-value: 9.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927  17 LDCLQSvyASKTQ-YRYEVIVIDNHSSDGSVEAIR---AAYPEIMLI-----ANQdntGFAKANNQGMEVASGRYVLLLN 87
Cdd:NF038302   20 LERLRS--QIGTEsLSWEIIVVDNNSTDNTAQVVQeyqKNWPSPYPLrycfePQQ---GAAFARQRAIQEAKGELIGFLD 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927  88 SDTLVQPDTLDTMIRFMDTHPEMGASGCKvILPDgsldkackrgFPTPSasfyyafgwskryPDN--------------P 153
Cdd:NF038302   95 DDNLPAPNWVAAAYAFGQEHPQAGAYGSQ-IHGD----------FEVEP-------------PENferiapflaitergN 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927 154 KYNQYQLGH--LSPddeypvdvlvGAFMLVRRET-IDQV------GGLDETFFMYGEDIDWCYRIKQAGWGIYYYPHTYI 224
Cdd:NF038302  151 EPLLYEPKKklLPP----------GAGLVVRKQAwLESVperlilTGRVGGSMLTGEDLEALLYIQKAGWEIWYNPAMHI 220


                  ...
gi 1938978927 225 IHI 227
Cdd:NF038302  221 YHK 223
glyco_TIGR04440 TIGR04440
glycosyltransferase domain; This model describes a putative glycotransferase domain, related ...
 2-146 6.12e-03

glycosyltransferase domain; This model describes a putative glycotransferase domain, related to the group 2 family glycosyltransferases of pfam00535.


Pssm-ID: 275233  Cd Length: 215  Bit Score: 37.28  E-value: 6.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927   2 DVSILVVNYNTCRLTLDCLQsvYASKTQYRYEVIVIDnhSSDGSVEAIRAAYPEIMLIAN-------QDNTGFAKANNQG 74
Cdd:TIGR04440   1 KLTIIIPTYNRPEYLKRWLR--YYSDFGCDYRIIIAD--SSDEKFNENNLKVFKNYSNPNitylhypDLGVPFYEKLLDA 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1938978927  75 MEVASGRYVLLLNSDTLVQPDTLDTMIRFMDTHPE-MGASGCKVILPDGSLDKACKRgfptpsaSFYYAFGWS 146
Cdd:TIGR04440  77 LEQVETPYVVICADDDFIIPSGLTECLSFLEANPDySAAQGRYVYFEDRGDRVYGDQ-------PFQYYPDYS 142
 
Name Accession Description Interval E-value
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 5-226 1.81e-68

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 210.49  E-value: 1.81e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927   5 ILVVNYNTCRLTLDCLQSVYAsKTQYRYEVIVIDNHSSDGSVEAIRAAYPEIMLIANQDNTGFAKANNQGMEVASGRYVL 84
Cdd:cd04186     1 IIIVNYNSLEYLKACLDSLLA-QTYPDFEVIVVDNASTDGSVELLRELFPEVRLIRNGENLGFGAGNNQGIREAKGDYVL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927  85 LLNSDTLVQPDTLDTMIRFMDTHPEMGASGCKVIlpdgsldkackrgfptpsasfyyafgwskrypdnpkynqyqlghls 164
Cdd:cd04186    80 LLNPDTVVEPGALLELLDAAEQDPDVGIVGPKVS---------------------------------------------- 113

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1938978927 165 pddeypvdvlvGAFMLVRRETIDQVGGLDETFFMYGEDIDWCYRIKQAGWGIYYYPHTYIIH 226
Cdd:cd04186   114 -----------GAFLLVRREVFEEVGGFDEDFFLYYEDVDLCLRARLAGYRVLYVPQAVIYH 164
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
1-262 4.17e-64

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 200.60  E-value: 4.17e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927   1 MDVSILVVNYNTCRLTLDCLQSVYASkTQYRYEVIVIDNHSSDGSVEAIRA-AYPEIMLIANQDNTGFAKANNQGMEVAS 79
Cdd:COG1216     3 PKVSVVIPTYNRPELLRRCLESLLAQ-TYPPFEVIVVDNGSTDGTAELLAAlAFPRVRVIRNPENLGFAAARNLGLRAAG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927  80 GRYVLLLNSDTLVQPDTLDTMIRFmdthpemgasgckvilpdgsldkackrgfptpsasfyyafgwskrypdnpkynqyq 159
Cdd:COG1216    82 GDYLLFLDDDTVVEPDWLERLLAA-------------------------------------------------------- 105

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927 160 lghlspddeypvdvlvgAFMLVRRETIDQVGGLDETFFMYGEDIDWCYRIKQAGWGIYYYPHTYIIHIKGGSarRRPLKI 239
Cdd:COG1216   106 -----------------ACLLIRREVFEEVGGFDERFFLYGEDVDLCLRLRKAGYRIVYVPDAVVYHLGGAS--SGPLLR 166

                         250       260
                  ....*....|....*....|...
gi 1938978927 240 IYEFHRAMWVFHRKHYKQQYSWF 262
Cdd:COG1216   167 AYYLGRNRLLFLRKHGPRPLLRL 189
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-240 1.86e-28

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 108.64  E-value: 1.86e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927   1 MDVSILVVNYNTCRLTLDCLQSVYASkTQYRYEVIVIDNHSSDGSVEAIR---AAYPEIMLIANQDNTGFAKANNQGMEV 77
Cdd:COG0463     2 PLVSVVIPTYNEEEYLEEALESLLAQ-TYPDFEIIVVDDGSTDGTAEILRelaAKDPRIRVIRLERNRGKGAARNAGLAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927  78 ASGRYVLLLNSDTLVQPDTLDTMIRFMDTHPEMGASGCKVIlpdgsldKACKRGFPTPSASFYYAFGWSKRYPDNPkynq 157
Cdd:COG0463    81 ARGDYIAFLDADDQLDPEKLEELVAALEEGPADLVYGSRLI-------REGESDLRRLGSRLFNLVRLLTNLPDST---- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927 158 yqlghlspddeypvdvlvGAFMLVRRETIDQVgGLDETFFmygEDIDWcYRIKQAGWGIYYYPHTYIIHiKGGSARRRPL 237
Cdd:COG0463   150 ------------------SGFRLFRREVLEEL-GFDEGFL---EDTEL-LRALRHGFRIAEVPVRYRAG-ESKLNLRDLL 205


                  ...
gi 1938978927 238 KII 240
Cdd:COG0463   206 RLL 208
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 1-280 3.26e-25

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 102.13  E-value: 3.26e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927   1 MDVSILVVNYNTCRLTLDCLQSVYASK-TQYRYEVIVIDNHSSDGSVEAIRAA---YPEIMLIANQDNTGFAKANNQGME 76
Cdd:COG1215    29 PRVSVIIPAYNEEAVIEETLRSLLAQDyPKEKLEVIVVDDGSTDETAEIARELaaeYPRVRVIERPENGGKAAALNAGLK 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927  77 VASGRYVLLLNSDTLVQPDTLDTMIRFMDtHPEMGASGCkvilpdgsldkackrgfptpsasfyyafgwskrypdnpkyn 156
Cdd:COG1215   109 AARGDIVVFLDADTVLDPDWLRRLVAAFA-DPGVGASGA----------------------------------------- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927 157 qyqlghlspddeypvdvlvgaFMLVRRETIDQVGGLDEtfFMYGEDIDWCYRIKQAGWGIYYYPHTYIIHikggsarRRP 236
Cdd:COG1215   147 ---------------------NLAFRREALEEVGGFDE--DTLGEDLDLSLRLLRAGYRIVYVPDAVVYE-------EAP 196

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1938978927 237 LKIIYEFHRAM-WVFHRKHYKQQYSWFTNMAVYAGITVKFGMAFL 280
Cdd:COG1215   197 ETLRALFRQRRrWARGGLQLLLKHRPLLRPRRLLLFLLLLLLPLL 241
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 5-218 3.99e-23

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 92.95  E-value: 3.99e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927   5 ILVVNYNTCRLTLDCLQSVYASkTQYRYEVIVIDNHSSDGSVEAIRAA---YPEIMLIANQDNTGFAKANNQGMEVASGR 81
Cdd:cd00761     1 VIIPAYNEEPYLERCLESLLAQ-TYPNFEVIVVDDGSTDGTLEILEEYakkDPRVIRVINEENQGLAAARNAGLKAARGE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927  82 YVLLLNSDTLVQPDTLDTMIRFMDTHPEMGASGCKvilpdgsldkackrgfptpsasfyyafgwskrypdnpkynqyqlg 161
Cdd:cd00761    80 YILFLDADDLLLPDWLERLVAELLADPEADAVGGP--------------------------------------------- 114

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1938978927 162 hlspddeypvdvlvgAFMLVRRETIDQVGGLDETFFMYGEDIDWCYRIKQAGWGIYY 218
Cdd:cd00761   115 ---------------GNLLFRRELLEEIGGFDEALLSGEEDDDFLLRLLRGGKVAFR 156
GT2_RfbF_like cd02526
RfbF is a putative dTDP-rhamnosyl transferase; Shigella flexneri RfbF protein is a putative ...
 6-244 1.57e-22

RfbF is a putative dTDP-rhamnosyl transferase; Shigella flexneri RfbF protein is a putative dTDP-rhamnosyl transferase. dTDP rhamnosyl transferases of Shigella flexneri add rhamnose sugars to N-acetyl-glucosamine in the O-antigen tetrasaccharide repeat. Lipopolysaccharide O antigens are important virulence determinants for many bacteria. The variations of sugar composition, the sequence of the sugars and the linkages in the O antigen provide structural diversity of the O antigen.


Pssm-ID: 133017 [Multi-domain]  Cd Length: 237  Bit Score: 93.50  E-value: 1.57e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927   6 LVVNYN-TCRLTLDCLQSVYASKTqyryEVIVIDNHSsdGSVEAIRAAYPE--IMLIANQDNTGFAKANNQGMEVASGR- 81
Cdd:cd02526     2 VVVTYNpDLSKLKELLAALAEQVD----KVVVVDNSS--GNDIELRLRLNSekIELIHLGENLGIAKALNIGIKAALENg 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927  82 --YVLLLNSDTLVQPDTLDTMIRFmdthpemgasgckvilpDGSLDKACKRGFPTPSasFYYAFGWSKRYPDNPKYNQYQ 159
Cdd:cd02526    76 adYVLLFDQDSVPPPDMVEKLLAY-----------------KILSDKNSNIGAVGPR--IIDRRTGENSPGVRKSGYKLR 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927 160 LGHLSPDDEYPVDVLVGAFMLVRRETIDQVGGLDETFFMYGEDIDWCYRIKQAGWGIYYYPHTYIIHIKGGSARRRPLKI 239
Cdd:cd02526   137 IQKEGEEGLKEVDFLITSGSLISLEALEKVGGFDEDLFIDYVDTEWCLRARSKGYKIYVVPDAVLKHELGDKRVKRLGGV 216


                  ....*
gi 1938978927 240 IYEFH 244
Cdd:cd02526   217 SVPLH 221
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 5-202 3.63e-21

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 88.44  E-value: 3.63e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927   5 ILVVNYN---TCRLTLD-CLQSVYAsktqyRYEVIVIDNHSSDGSVEAIRAAYPE----IMLIANQDNTGFAKANNQGME 76
Cdd:cd06423     1 IIVPAYNeeaVIERTIEsLLALDYP-----KLEVIVVDDGSTDDTLEILEELAALyirrVLVVRDKENGGKAGALNAGLR 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927  77 VASGRYVLLLNSDTLVQPDTLDTMIRFMDTHPEMGASGCKVILPDGSldkackRGFPTPSASFYY--AFGWSKRypdnpk 154
Cdd:cd06423    76 HAKGDIVVVLDADTILEPDALKRLVVPFFADPKVGAVQGRVRVRNGS------ENLLTRLQAIEYlsIFRLGRR------ 143

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1938978927 155 yNQYQLGHLSpddeypvdVLVGAFMLVRRETIDQVGGLDETffMYGED 202
Cdd:cd06423   144 -AQSALGGVL--------VLSGAFGAFRREALREVGGWDED--TLTED 180
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 4-114 4.56e-20

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 85.14  E-value: 4.56e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927   4 SILVVNYNTCRLTLDCLQSVyASKTQYRYEVIVIDNHSSDGSVEAIRAA---YPEIMLIANQDNTGFAKANNQGMEVASG 80
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESL-LNQTYPNFEIIVVDDGSTDGTVEIAEEYakkDPRVRVIRLPENRGKAGARNAGLRAATG 79

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1938978927  81 RYVLLLNSDTLVQPDTLDTMIRFMDTHPEMGASG 114
Cdd:pfam00535  80 DYIAFLDADDEVPPDWLEKLVEALEEDGADVVVG 113
GT_2_WfgS_like cd06433
WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella ...
 4-222 2.97e-18

WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133055 [Multi-domain]  Cd Length: 202  Bit Score: 81.05  E-value: 2.97e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927   4 SILVVNYNtCRLTL-DCLQSVyASKTQYRYEVIVIDNHSSDGSVEAIRAaYPEIM--LIANQDNtGFAKANNQGMEVASG 80
Cdd:cd06433     1 SIITPTYN-QAETLeETIDSV-LSQTYPNIEYIVIDGGSTDGTVDIIKK-YEDKItyWISEPDK-GIYDAMNKGIALATG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927  81 RYVLLLNSDTLVQPDTLDTMIRFMDTHPEMGASGCKVILPDGSLDKAcKRGFPTPSASFYYAFGWSkrypdnpkynqyqL 160
Cdd:cd06433    77 DIIGFLNSDDTLLPGALLAVVAAFAEHPEVDVVYGDVLLVDENGRVI-GRRRPPPFLDKFLLYGMP-------------I 142

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1938978927 161 GHLSpddeypvdvlvgafMLVRRETIDQVGGLDETFFMYGeDIDWCYRIKQAGWGIYYYPHT 222
Cdd:cd06433   143 CHQA--------------TFFRRSLFEKYGGFDESYRIAA-DYDLLLRLLLAGKIFKYLPEV 189
Glyco_tranf_2_3 pfam13641
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 2-221 9.74e-17

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433372 [Multi-domain]  Cd Length: 230  Bit Score: 77.41  E-value: 9.74e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927   2 DVSILVVNYNTCRLTLDCLQSvyASKTQY-RYEVIVIDNHSSDG---SVEAIRAAYP--EIMLIANQDN---TGFAKANN 72
Cdd:pfam13641   3 DVSVVVPAFNEDSVLGRVLEA--ILAQPYpPVEVVVVVNPSDAEtldVAEEIAARFPdvRLRVIRNARLlgpTGKSRGLN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927  73 QGMEVASGRYVLLLNSDTLVQPDTLDTMIRFMDTHPeMGASGCKVilpdgsldkACKRgfPTPSASFYYAFgwskrypdn 152
Cdd:pfam13641  81 HGFRAVKSDLVVLHDDDSVLHPGTLKKYVQYFDSPK-VGAVGTPV---------FSLN--RSTMLSALGAL--------- 139

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1938978927 153 pKYNQYQLGHLSPDDEYPVDVLVGAFMLVRRETIDQVGGLDEtFFMYGEDIDWCYRIKQAGWGIYYYPH 221
Cdd:pfam13641 140 -EFALRHLRMMSLRLALGVLPLSGAGSAIRREVLKELGLFDP-FFLLGDDKSLGRRLRRHGWRVAYAPD 206
GT_2_like_b cd04185
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 6-226 4.94e-16

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133028 [Multi-domain]  Cd Length: 202  Bit Score: 74.98  E-value: 4.94e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927   6 LVVNYNTCRLTLDCLQSVYASkTQYRYEVIVIDNHSSDGSVEAIRAAYPE--IMLIANQDNTGFAKANNQGMEVASGR-- 81
Cdd:cd04185     2 VVVTYNRLDLLKECLDALLAQ-TRPPDHIIVIDNASTDGTAEWLTSLGDLdnIVYLRLPENLGGAGGFYEGVRRAYELgy 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927  82 -YVLLLNSDTLVQPDTLDTMIRFMDtHPEMGASGCKVILPDGSldkackrgFptpsasfyyafgwskrypdnpkynqyql 160
Cdd:cd04185    81 dWIWLMDDDAIPDPDALEKLLAYAD-KDNPQFLAPLVLDPDGS--------F---------------------------- 123

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1938978927 161 ghlspddeypvdvlVGafMLVRRETIDQVGGLDETFFMYGEDIDWCYRIKQAGwGIYYYPHTYIIH 226
Cdd:cd04185   124 --------------VG--VLISRRVVEKIGLPDKEFFIWGDDTEYTLRASKAG-PGIYVPDAVVVH 172
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 3-220 1.89e-13

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 68.80  E-value: 1.89e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927   3 VSILVVNYNTCRLTLDCLQSVYASKT-QYRYEVIVIDNHSSDGSVE---AIRAAYPEIMLIANQDNTgFAKANNQGMEVA 78
Cdd:cd02525     2 VSIIIPVRNEEKYIEELLESLLNQSYpKDLIEIIVVDGGSTDGTREivqEYAAKDPRIRLIDNPKRI-QSAGLNIGIRNS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927  79 SGRYVLLLNSDTLVQPDTLDTMIRFMDTHPEMGASGCKVILPDGSLDKACKRGFPTPSASFYYAFgwskRYPDNpkynqy 158
Cdd:cd02525    81 RGDIIIRVDAHAVYPKDYILELVEALKRTGADNVGGPMETIGESKFQKAIAVAQSSPLGSGGSAY----RGGAV------ 150

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1938978927 159 qlghlspdDEYPVDVLVGAFMlvRRETIDQVGGLDETfFMYGEDIDWCYRIKQAGWGIYYYP 220
Cdd:cd02525   151 --------KIGYVDTVHHGAY--RREVFEKVGGFDES-LVRNEDAELNYRLRKAGYKIWLSP 201
GT2_RfbC_Mx_like cd04184
Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene ...
 3-196 2.66e-12

Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene encodes a predicted protein of 1,276 amino acids, which is required for O-antigen biosynthesis in Myxococcus xanthus. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133027 [Multi-domain]  Cd Length: 202  Bit Score: 64.53  E-value: 2.66e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927   3 VSILVVNYNTCRLTLD-CLQSVyasKTQY--RYEVIVIDNHSSDGSVEAIRAAYPE----IMLIANQDNTGFAKANNQGM 75
Cdd:cd04184     3 ISIVMPVYNTPEKYLReAIESV---RAQTypNWELCIADDASTDPEVKRVLKKYAAqdprIKVVFREENGGISAATNSAL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927  76 EVASGRYVLLLNSDTLVQPDTLDTMIRFMDTHPEmgasgCKVILPD-GSLDKACKRGFPtpsasfYYAFGWSkryPDNPK 154
Cdd:cd04184    80 ELATGEFVALLDHDDELAPHALYEVVKALNEHPD-----ADLIYSDeDKIDEGGKRSEP------FFKPDWS---PDLLL 145

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1938978927 155 YNQYqLGHLSpddeypvdvlvgafmLVRRETIDQVGGLDETF 196
Cdd:cd04184   146 SQNY-IGHLL---------------VYRRSLVRQVGGFREGF 171
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 3-101 1.85e-11

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 63.53  E-value: 1.85e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927   3 VSILVVNYNTCRLTLDCLQSVYAsKTQYRYEVIVIDNHSSDGSVEAI---RAAYPEIMLIAnQDNTGFAKANNQGMEVAS 79
Cdd:PRK10073    8 LSIIIPLYNAGKDFRAFMESLIA-QTWTALEIIIVNDGSTDNSVEIAkhyAENYPHVRLLH-QANAGVSVARNTGLAVAT 85

                          90       100
                  ....*....|....*....|..
gi 1938978927  80 GRYVLLLNSDTLVQPDTLDTMI 101
Cdd:PRK10073   86 GKYVAFPDADDVVYPTMYETLM 107
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 19-222 9.23e-11

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 60.77  E-value: 9.23e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927  19 CLQSVyaSKTQY---RYEVIVIDNHSSDGSVEAIRAAY----PEIMLIANQD--NTGFAKANNQGMEVASGRYVLLLNSD 89
Cdd:cd04192    15 LLQSL--SALDYpkeKFEVILVDDHSTDGTVQILEFAAakpnFQLKILNNSRvsISGKKNALTTAIKAAKGDWIVTTDAD 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927  90 TLVQPDTLDTMIRFM-DTHPEMGASGCKVILPDGSLDKACKRGFPTPSASFYYAFGWSKRYPDNpkynqyqlghlspdde 168
Cdd:cd04192    93 CVVPSNWLLTFVAFIqKEQIGLVAGPVIYFKGKSLLAKFQRLDWLSLLGLIAGSFGLGKPFMCN---------------- 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1938978927 169 ypvdvlvGAFMLVRRETIDQVGGLDETFFMYGEDIDWCYRIKQAGWG-IYYYPHT 222
Cdd:cd04192   157 -------GANMAYRKEAFFEVGGFEGNDHIASGDDELLLAKVASKYPkVAYLKNP 204
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 30-89 2.48e-09

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 55.66  E-value: 2.48e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1938978927  30 YRYEVIVIDNHSSDGSVEAIR---AAYPEIMLIANQDNTGFAKANNQGMEVASGRYVLLLNSD 89
Cdd:cd04179    27 YDYEIIVVDDGSTDGTAEIARelaARVPRVRVIRLSRNFGKGAAVRAGFKAARGDIVVTMDAD 89
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 3-129 5.69e-09

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 55.67  E-value: 5.69e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927   3 VSILVVNYNTCRLTLDCLQSVYASKtqY---RYEVIVIDNHSSDGSVEAIRA-AYPEIMLIANQDNTGFAKANNQGMEVA 78
Cdd:cd06439    31 VTIIIPAYNEEAVIEAKLENLLALD--YprdRLEIIVVSDGSTDGTAEIAREyADKGVKLLRFPERRGKAAALNRALALA 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1938978927  79 SGRYVLLLNSDTLVQPDTLDTMIR-FMDthPEMGA-SGCKVILPDGSLDKACK 129
Cdd:cd06439   109 TGEIVVFTDANALLDPDALRLLVRhFAD--PSVGAvSGELVIVDGGGSGSGEG 159
DPM1_like_bac cd04187
Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes ...
 20-198 8.17e-09

Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133030 [Multi-domain]  Cd Length: 181  Bit Score: 54.02  E-value: 8.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927  20 LQSVYASKTqYRYEVIVIDNHSSDGSVEAIR---AAYPEIMLIANQDNTGFAKANNQGMEVASGRYVLLLNSDTLVQPDT 96
Cdd:cd04187    19 LKAVLESLG-YDYEIIFVDDGSTDRTLEILRelaARDPRVKVIRLSRNFGQQAALLAGLDHARGDAVITMDADLQDPPEL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927  97 LDTMIRFMDthpemgaSGCKVI--LPDGSLDKACKRgfpTPSASFYYAFGW--SKRYPDNpkynqyqlghlspddeypvd 172
Cdd:cd04187    98 IPEMLAKWE-------EGYDVVygVRKNRKESWLKR---LTSKLFYRLINKlsGVDIPDN-------------------- 147

                         170       180
                  ....*....|....*....|....*..
gi 1938978927 173 vlVGAFMLVRRETIDQVGGLDETF-FM 198
Cdd:cd04187   148 --GGDFRLMDRKVVDALLLLPERHrFL 172
Glyco_trans_2_3 pfam13632
Glycosyl transferase family group 2; Members of this family of prokaryotic proteins include ...
 82-255 1.07e-08

Glycosyl transferase family group 2; Members of this family of prokaryotic proteins include putative glucosyltransferases, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433365 [Multi-domain]  Cd Length: 192  Bit Score: 53.88  E-value: 1.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927  82 YVLLLNSDTLVQPDTLDTMIRFMDThPEMGASGCKVilpdgsldkackrgFPTPSASFYYAFGWSKrypdnpkYNQYQLG 161
Cdd:pfam13632   1 WILLLDADTVLPPDCLLGIANEMAS-PEVAIIQGPI--------------LPMNVGNYLEELAALF-------FADDHGK 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927 162 HLsPDDEYPVDVL--VGAFMLVRRETIDQVGGLDETFfmYGEDIDWCYRIKQAGWGIYYYPHTyIIHIKGGS----ARRR 235
Cdd:pfam13632  59 SI-PVRMALGRVLpfVGSGAFLRRSALQEVGGWDDGS--VSEDFDFGLRLQRAGYRVRFAPYS-AVYEKSPLtfrdFLRQ 134

                         170       180
                  ....*....|....*....|
gi 1938978927 236 PLKIIYEFHRAMWVFHRKHY 255
Cdd:pfam13632 135 RRRWAYGCLLILLIRLLGYL 154
PLN02726 PLN02726
dolichyl-phosphate beta-D-mannosyltransferase
 1-102 1.23e-07

dolichyl-phosphate beta-D-mannosyltransferase


Pssm-ID: 215385 [Multi-domain]  Cd Length: 243  Bit Score: 51.62  E-value: 1.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927   1 MDVSILVVNYNTCR-------LTLDCLQSVYasktqyRYEVIVIDNHSSDGS---VEAIRAAYPE--IMLIANQDNTGFA 68
Cdd:PLN02726    9 MKYSIIVPTYNERLnialivyLIFKALQDVK------DFEIIVVDDGSPDGTqdvVKQLQKVYGEdrILLRPRPGKLGLG 82

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1938978927  69 KANNQGMEVASGRYVLLLNSDTLVQPDTLDTMIR 102
Cdd:PLN02726   83 TAYIHGLKHASGDFVVIMDADLSHHPKYLPSFIK 116
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 33-234 2.74e-07

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 50.26  E-value: 2.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927  33 EVIVIDNHSSDGSVEAIRAAYpeIMLI------ANQDNTGfAKAnnqgmevASGRYVLLLNSDTLVQPDTLDTMIRfmdT 106
Cdd:cd02522    30 EIIVVDGGSTDGTVAIARSAG--VVVIsspkgrARQMNAG-AAA-------ARGDWLLFLHADTRLPPDWDAAIIE---T 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927 107 HPEMGAS-GCkvilpdgsldkaCKRGFPTPSASF-YYAFGWSKRYPdnpkynqyqLGHLspddeypvdvlvgAF----ML 180
Cdd:cd02522    97 LRADGAVaGA------------FRLRFDDPGPRLrLLELGANLRSR---------LFGL-------------PYgdqgLF 142

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1938978927 181 VRRETIDQVGGLDETFFMygEDIDWCYRIKQAGWgiyyyphtyIIHIKGG---SARR 234
Cdd:cd02522   143 IRRELFEELGGFPELPLM--EDVELVRRLRRRGR---------PALLPSPvttSARR 188
EPS_HpsE NF038302
hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;
17-227 9.32e-07

hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;


Pssm-ID: 439602 [Multi-domain]  Cd Length: 307  Bit Score: 49.41  E-value: 9.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927  17 LDCLQSvyASKTQ-YRYEVIVIDNHSSDGSVEAIR---AAYPEIMLI-----ANQdntGFAKANNQGMEVASGRYVLLLN 87
Cdd:NF038302   20 LERLRS--QIGTEsLSWEIIVVDNNSTDNTAQVVQeyqKNWPSPYPLrycfePQQ---GAAFARQRAIQEAKGELIGFLD 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927  88 SDTLVQPDTLDTMIRFMDTHPEMGASGCKvILPDgsldkackrgFPTPSasfyyafgwskryPDN--------------P 153
Cdd:NF038302   95 DDNLPAPNWVAAAYAFGQEHPQAGAYGSQ-IHGD----------FEVEP-------------PENferiapflaitergN 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927 154 KYNQYQLGH--LSPddeypvdvlvGAFMLVRRET-IDQV------GGLDETFFMYGEDIDWCYRIKQAGWGIYYYPHTYI 224
Cdd:NF038302  151 EPLLYEPKKklLPP----------GAGLVVRKQAwLESVperlilTGRVGGSMLTGEDLEALLYIQKAGWEIWYNPAMHI 220


                  ...
gi 1938978927 225 IHI 227
Cdd:NF038302  221 YHK 223
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 3-113 1.00e-06

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 48.82  E-value: 1.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927   3 VSILVVNYNTCRLTLDCLQSVyasKTQYRyEVIVIDNHSSDGSVEAIRAAYPEIMLIANQdntGFAKANNQGMEVASGRY 82
Cdd:cd02511     2 LSVVIITKNEERNIERCLESV---KWAVD-EIIVVDSGSTDRTVEIAKEYGAKVYQRWWD---GFGAQRNFALELATNDW 74

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1938978927  83 VLLLNSDTLVQPDTLDTMIRFMDTHPEMGAS 113
Cdd:cd02511    75 VLSLDADERLTPELADEILALLATDDYDGYY 105
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 14-101 2.04e-06

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 47.56  E-value: 2.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927  14 RL--TLDCLQSVYASKTQYRYEVIVIDNHSSDGS---VEAIRAAYPEIM-LIANQDNTGFAKANNQGMEVASGRYVLLLN 87
Cdd:cd04188    11 RLppTLEEAVEYLEERPSFSYEIIVVDDGSKDGTaevARKLARKNPALIrVLTLPKNRGKGGAVRAGMLAARGDYILFAD 90

                          90
                  ....*....|....
gi 1938978927  88 SDTLVQPDTLDTMI 101
Cdd:cd04188    91 ADLATPFEELEKLE 104
DPM1_like cd06442
DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to ...
 30-89 1.66e-05

DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133062 [Multi-domain]  Cd Length: 224  Bit Score: 45.22  E-value: 1.66e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1938978927  30 YRYEVIVIDNHSSDGS---VEAIRAAYPEIMLIANQDNTGFAKANNQGMEVASGRYVLLLNSD 89
Cdd:cd06442    26 IDYEIIVVDDNSPDGTaeiVRELAKEYPRVRLIVRPGKRGLGSAYIEGFKAARGDVIVVMDAD 88
CESA_NdvC_like cd06435
NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; ...
 32-223 3.20e-05

NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase; NdvC_like proteins in this family are putative bacterial beta-(1,6)-glucosyltransferase. Bradyrhizobium japonicum synthesizes periplasmic cyclic beta-(1,3),beta-(1,6)-D-glucans during growth under hypoosmotic conditions. Two genes (ndvB, ndvC) are involved in the beta-(1, 3), beta-(1,6)-glucan synthesis. The ndvC mutant strain resulted in synthesis of altered cyclic beta-glucans composed almost entirely of beta-(1, 3)-glycosyl linkages. The periplasmic cyclic beta-(1,3),beta-(1,6)-D-glucans function for osmoregulation. The ndvC mutation also affects the ability of the bacteria to establish a successful symbiotic interaction with host plant. Thus, the beta-glucans may function as suppressors of a host defense response.


Pssm-ID: 133057 [Multi-domain]  Cd Length: 236  Bit Score: 44.31  E-value: 3.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927  32 YEVIVIDNHSSDGS----VEAIRAAYPEIMLIANQDN-TGF-AKANNQGMEVASG--RYVLLLNSDTLVQPDTLDTMIRF 103
Cdd:cd06435    29 FEVIVIDNNTKDEAlwkpVEAHCAQLGERFRFFHVEPlPGAkAGALNYALERTAPdaEIIAVIDADYQVEPDWLKRLVPI 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927 104 MDtHPEMGAsgckVILPDGSLDKAckrgfptpSASFYYAFGWSKRYPDN---PKYNqyqlghlspddEYPVDVLVGAFML 180
Cdd:cd06435   109 FD-DPRVGF----VQAPQDYRDGE--------ESLFKRMCYAEYKGFFDigmVSRN-----------ERNAIIQHGTMCL 164

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1938978927 181 VRRETIDQVGGLDETFFMygEDIDWCYRIKQAGWGIYYYPHTY 223
Cdd:cd06435   165 IRRSALDDVGGWDEWCIT--EDSELGLRMHEAGYIGVYVAQSY 205
Glucosylceramide_synthase cd02520
Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid ...
 31-111 5.16e-05

Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; UDP-glucose:N-acylsphingosine D-glucosyltransferase (glucosylceramide synthase or ceramide glucosyltransferase) catalyzes the first glycosylation step of glycosphingolipid synthesis. Its product, glucosylceramide, serves as the core of more than 300 glycosphingolipids (GSL). GSLs are a group of membrane components that have the lipid portion embedded in the outer plasma membrane leaflet and the sugar chains extended to the outer environment. Several lines of evidence suggest the importance of GSLs in various cellular processes such as differentiation, adhesion, proliferation, and cell-cell recognition. In pathogenic fungus Cryptococcus neoformans, glucosylceramide serves as an antigen that elicits an antibody response in patients and it is essential for fungal growth in host extracellular environment.


Pssm-ID: 133012 [Multi-domain]  Cd Length: 196  Bit Score: 43.35  E-value: 5.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927  31 RYEVIVIDNHSSDGSVEAIR---AAYPEIM---LIANQDNTGFAKANN--QGMEVASGRYVLLLNSDTLVQPDTLDTMIR 102
Cdd:cd02520    30 KYEILFCVQDEDDPAIPVVRkliAKYPNVDarlLIGGEKVGINPKVNNliKGYEEARYDILVISDSDISVPPDYLRRMVA 109


                  ....*....
gi 1938978927 103 FMDThPEMG 111
Cdd:cd02520   110 PLMD-PGVG 117
GT2_HAS cd06434
Hyaluronan synthases catalyze polymerization of hyaluronan; Hyaluronan synthases (HASs) are ...
 2-121 1.59e-04

Hyaluronan synthases catalyze polymerization of hyaluronan; Hyaluronan synthases (HASs) are bi-functional glycosyltransferases that catalyze polymerization of hyaluronan. HASs transfer both GlcUA and GlcNAc in beta-(1,3) and beta-(1,4) linkages, respectively to the hyaluronan chain using UDP-GlcNAc and UDP-GlcUA as substrates. HA is made as a free glycan, not attached to a protein or lipid. HASs do not need a primer for HA synthesis; they initiate HA biosynthesis de novo with only UDP-GlcNAc, UDP-GlcUA, and Mg2+. Hyaluronan (HA) is a linear heteropolysaccharide composed of (1-3)-linked beta-D-GlcUA-beta-D-GlcNAc disaccharide repeats. It can be found in vertebrates and a few microbes and is typically on the cell surface or in the extracellular space, but is also found inside mammalian cells. Hyaluronan has several physiochemical and biological functions such as space filling, lubrication, and providing a hydrated matrix through which cells can migrate.


Pssm-ID: 133056 [Multi-domain]  Cd Length: 235  Bit Score: 42.24  E-value: 1.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927   2 DVSILVVNYNTCRLTL-DCLQSVYASKtqyRYEVIVIDNHSSDGSVEAIRAA--YPEIMLIAnQDNTGFAKANNQGMEVA 78
Cdd:cd06434     1 DVTVIIPVYDEDPDVFrECLRSILRQK---PLEIIVVTDGDDEPYLSILSQTvkYGGIFVIT-VPHPGKRRALAEGIRHV 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1938978927  79 SGRYVLLLNSDTLVQPDTLDTMIR-FMDthPEMGA-SGCKVILPD 121
Cdd:cd06434    77 TTDIVVLLDSDTVWPPNALPEMLKpFED--PKVGGvGTNQRILRP 119
beta3GnTL1_like cd06913
Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of ...
 5-123 6.43e-04

Beta 1, 3-N-acetylglucosaminyltransferase is essential for the formation of poly-N-acetyllactosamine ; This family includes human Beta3GnTL1 and related eukaryotic proteins. Human Beta3GnTL1 is a putative beta-1,3-N-acetylglucosaminyltransferase. Beta3GnTL1 is expressed at various levels in most of tissues examined. Beta 1, 3-N-acetylglucosaminyltransferase has been found to be essential for the formation of poly-N-acetyllactosamine. Poly-N-acetyllactosamine is a unique carbohydrate composed of N-acetyllactosamine repeats. It is often an important part of cell-type-specific oligosaccharide structures and some functional oligosaccharides. It has been shown that the structure and biosynthesis of poly-N-acetyllactosamine display a dramatic change during development and oncogenesis. Several members of beta-1, 3-N-acetylglucosaminyltransferase have been identified.


Pssm-ID: 133063 [Multi-domain]  Cd Length: 219  Bit Score: 40.13  E-value: 6.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927   5 ILVVNYNTCRLTLDCLQSVYASKTQYRYEVIVIDNHSSDGSVEAI-------RAAYPEIMLIANQDNT----GFAKanNQ 73
Cdd:cd06913     1 IILPVHNGEQWLDECLESVLQQDFEGTLELSVFNDASTDKSAEIIekwrkklEDSGVIVLVGSHNSPSpkgvGYAK--NQ 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1938978927  74 GMEVASGRYVLLLNSDTLVQPDTLDTMIRFMDTHPEmGASGCKVI-LPDGS 123
Cdd:cd06913    79 AIAQSSGRYLCFLDSDDVMMPQRIRLQYEAALQHPN-SIIGCQVRrIPEDS 128
GT2_Chondriotin_Pol_N cd06420
N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin ...
 19-95 1.95e-03

N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin polymerase is a two domain, bi-functional protein. The N-terminal domain functions as a GalNAc transferase. The bacterial chondroitin polymerase catalyzes elongation of the chondroitin chain by alternatively transferring the GlcUA and GalNAc moiety from UDP-GlcUA and UDP-GalNAc to the non-reducing ends of the chondroitin chain. The enzyme consists of N-terminal and C-terminal domains in which the two active sites catalyze the addition of GalNAc and GlcUA, respectively. Chondroitin chains range from 40 to over 100 repeating units of the disaccharide. Sulfated chondroitins are involved in the regulation of various biological functions such as central nervous system development, wound repair, infection, growth factor signaling, and morphogenesis, in addition to its conventional structural roles. In Caenorhabditis elegans, chondroitin is an essential factor for the worm to undergo cytokinesis and cell division. Chondroitin is synthesized as proteoglycans, sulfated and secreted to the cell surface or extracellular matrix.


Pssm-ID: 133042 [Multi-domain]  Cd Length: 182  Bit Score: 38.33  E-value: 1.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927  19 CLQSVyASKTQYRYEVIVIDnhssDGSVEAIRA---AYPEIMLIA----NQDNTGF--AKANNQGMEVASGRYVLLLNSD 89
Cdd:cd06420    15 VLKSV-LNQSILPFEVIIAD----DGSTEETKElieEFKSQFPIPikhvWQEDEGFrkAKIRNKAIAAAKGDYLIFIDGD 89


                  ....*.
gi 1938978927  90 TLVQPD 95
Cdd:cd06420    90 CIPHPD 95
PTZ00260 PTZ00260
dolichyl-phosphate beta-glucosyltransferase; Provisional
 1-104 4.17e-03

dolichyl-phosphate beta-glucosyltransferase; Provisional


Pssm-ID: 240336 [Multi-domain]  Cd Length: 333  Bit Score: 38.21  E-value: 4.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927   1 MDVSILVVNYN-------TCRLTLDCLQSVYASKTQYRYEVIVIDNHSSDGSVE-----AIRAAYPEI--MLIANQDNTG 66
Cdd:PTZ00260   70 VDLSIVIPAYNeedrlpkMLKETIKYLESRSRKDPKFKYEIIIVNDGSKDKTLKvakdfWRQNINPNIdiRLLSLLRNKG 149

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1938978927  67 FAKANNQGMEVASGRYVLLLNSDTLVQPDTLDTMIRFM 104
Cdd:PTZ00260  150 KGGAVRIGMLASRGKYILMVDADGATDIDDFDKLEDIM 187
GT2_AmsE_like cd04195
GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a ...
 19-114 4.92e-03

GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a glycosyltransferase involved in exopolysaccharide amylovora biosynthesis in Erwinia amylovora. Amylovara is one of the three exopolysaccharide produced by E. amylovora. Amylovara-deficient mutants are non-pathogenic. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133038 [Multi-domain]  Cd Length: 201  Bit Score: 37.29  E-value: 4.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927  19 CLQSVYASKTQYRYEVIVID---NHSSDGSVEAIRAAYPeIMLIANQDNTGFAKANNQGMEVASGRYVLLLNSDTLVQPD 95
Cdd:cd04195    18 ALESILKQTLPPDEVVLVKDgpvTQSLNEVLEEFKRKLP-LKVVPLEKNRGLGKALNEGLKHCTYDWVARMDTDDISLPD 96

                          90
                  ....*....|....*....
gi 1938978927  96 TLDTMIRFMDTHPEMGASG 114
Cdd:cd04195    97 RFEKQLDFIEKNPEIDIVG 115
glyco_TIGR04440 TIGR04440
glycosyltransferase domain; This model describes a putative glycotransferase domain, related ...
 2-146 6.12e-03

glycosyltransferase domain; This model describes a putative glycotransferase domain, related to the group 2 family glycosyltransferases of pfam00535.


Pssm-ID: 275233  Cd Length: 215  Bit Score: 37.28  E-value: 6.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927   2 DVSILVVNYNTCRLTLDCLQsvYASKTQYRYEVIVIDnhSSDGSVEAIRAAYPEIMLIAN-------QDNTGFAKANNQG 74
Cdd:TIGR04440   1 KLTIIIPTYNRPEYLKRWLR--YYSDFGCDYRIIIAD--SSDEKFNENNLKVFKNYSNPNitylhypDLGVPFYEKLLDA 76

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1938978927  75 MEVASGRYVLLLNSDTLVQPDTLDTMIRFMDTHPE-MGASGCKVILPDGSLDKACKRgfptpsaSFYYAFGWS 146
Cdd:TIGR04440  77 LEQVETPYVVICADDDFIIPSGLTECLSFLEANPDySAAQGRYVYFEDRGDRVYGDQ-------PFQYYPDYS 142
GT_2_like_d cd04196
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 33-124 8.54e-03

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133039 [Multi-domain]  Cd Length: 214  Bit Score: 36.84  E-value: 8.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1938978927  33 EVIVIDNHSSDGSVEAIR---AAYPEIMLIANQD-NTGFAKANNQGMEVASGRYVLLLNSDTLVQPDTLDTMIR--FMDT 106
Cdd:cd04196    29 ELIISDDGSTDGTVEIIKeyiDKDPFIIILIRNGkNLGVARNFESLLQAADGDYVFFCDQDDIWLPDKLERLLKafLKDD 108

                          90
                  ....*....|....*...
gi 1938978927 107 HPEMGASGCKVILPDGSL 124
Cdd:cd04196   109 KPLLVYSDLELVDENGNP 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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