BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4; KCNC2, also called Shaw-like potassium channel or voltage-gated potassium channel Kv3.2, is a delayed rectifier voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. It contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. KCNC4, also called KSHIIIC or voltage-gated potassium channel subunit Kv3.4, is a novel high-voltage-activating, tetraethylammonium (TEA)-sensitive, type-A potassium channel that mediates the voltage-dependent potassium ion permeability of excitable membranes. It plays a pivotal role in oxidative stress-related neural cell damage as an oxidation-sensitive channel. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC2 and KCNC4 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19354541  35 SEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPESDGGGAGSSGSSGGGGggggCEFFFDRHPGVFAYVLNYY 114
Cdd:cd18415   1 NERIILNVGGTRHETYRSTLKTLPGTRLALLASSDPQGDCLTQCSQVGGSDGSPGGG----NEFFFDRHPGVFAYVLNYY 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 19354541 115 RTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEAL 162
Cdd:cd18415  77 RTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEAL 124

Potassium voltage-gated channel; Fast inactivation of voltage-dependant potassium channels occurs by a 'ball-and-chain'-type mechanism. It controls membrane excitability and signal propagation in central neurons. Inactivation is regulated by protein phosphorylation where phosphorylation of serine residues leads to a reduction of the fast inactivation.

                          10        20
                  ....*....|....*....|....*....
gi 19354541     1 MISSVCVSSYRGRKSGNKPPSKTCLKEEM 29
Cdd:pfam11404   1 MISSVCVSSFRGRKSGNKSPSKSCLDEDM 29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4; KCNC2, also called Shaw-like potassium channel or voltage-gated potassium channel Kv3.2, is a delayed rectifier voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. It contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. KCNC4, also called KSHIIIC or voltage-gated potassium channel subunit Kv3.4, is a novel high-voltage-activating, tetraethylammonium (TEA)-sensitive, type-A potassium channel that mediates the voltage-dependent potassium ion permeability of excitable membranes. It plays a pivotal role in oxidative stress-related neural cell damage as an oxidation-sensitive channel. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC2 and KCNC4 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19354541  35 SEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPESDGGGAGSSGSSGGGGggggCEFFFDRHPGVFAYVLNYY 114
Cdd:cd18415   1 NERIILNVGGTRHETYRSTLKTLPGTRLALLASSDPQGDCLTQCSQVGGSDGSPGGG----NEFFFDRHPGVFAYVLNYY 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 19354541 115 RTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEAL 162
Cdd:cd18415  77 RTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEAL 124

BTB/POZ domain; In voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels. In KCTD1 this domain functions as a transcriptional repressor. It also mediates homomultimerization of KCTD1 and interaction of KCTD1 with the transcription factor AP-2-alpha.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19354541    38 IIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGG-RPESDgggagssgssggggggggcEFFFDRHPGVFAYVLNYYRT 116
Cdd:pfam02214   1 VKLNVGGTRFETLKSTLTRFPDTRLGRLLELECDDyDDDTN-------------------EYFFDRSPKHFETILNFYRT 61

                          90       100       110
                  ....*....|....*....|....*....|..
gi 19354541   117 -GKLHCPADVCGPLFEEELTFWGIDETDVEPC 147
Cdd:pfam02214  62 gGKLHRPEEVCLDEFLEEAEFYGLDELALELC 93

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19354541     38 IIINVGGTRHETYRSTLRTLPGTRLAWLAdpdgGGRPESDGGgagssgssggggggggCEFFFDRHPGVFAYVLNYYRTG 117
Cdd:smart00225   2 VTLVVGGKKFHAHKAVLAAHSPYFKALFS----SDFKESDKS----------------EIYLDDVSPEDFRALLNFLYTG 61

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 19354541    118 KLHCPADvCGPLFEEELTFWGIDEtDVEPCCWMTYRQH 155
Cdd:smart00225  62 KLDLPEE-NVEELLELADYLQIPG-LVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4; KCNC2, also called Shaw-like potassium channel or voltage-gated potassium channel Kv3.2, is a delayed rectifier voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. It contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system. KCNC4, also called KSHIIIC or voltage-gated potassium channel subunit Kv3.4, is a novel high-voltage-activating, tetraethylammonium (TEA)-sensitive, type-A potassium channel that mediates the voltage-dependent potassium ion permeability of excitable membranes. It plays a pivotal role in oxidative stress-related neural cell damage as an oxidation-sensitive channel. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNC2 and KCNC4 are alpha subunit that form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19354541  35 SEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPESDGGGAGSSGSSGGGGggggCEFFFDRHPGVFAYVLNYY 114
Cdd:cd18415   1 NERIILNVGGTRHETYRSTLKTLPGTRLALLASSDPQGDCLTQCSQVGGSDGSPGGG----NEFFFDRHPGVFAYVLNYY 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 19354541 115 RTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEAL 162
Cdd:cd18415  77 RTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEAL 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNC/Kv3 subfamily of Shaw-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv3, also known as subfamily C, contains four alpha subunit members, Kv3.1 (KCNC1), Kv3.2 (KCNC2), Kv3.3 (KCNC3), and Kv3.4 (KCNC4), which are orthologs of the Shaw gene in Drosophila. Unlike other Kv subfamilies, Kv3 channels typically open only at positive potentials and both, activation and deactivation, in response to changes in voltage are very rapid. They are uniquely associated with the ability of certain neurons to fire action potentials and to release neurotransmitter at high rates of up to 1,000 Hz. Kv3/KCNC subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19354541  38 IIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGrPESDGGGagssgssggggggggCEFFFDRHPGVFAYVLNYYRTG 117
Cdd:cd18379   1 IVINVGGVRHETYKSTLRNLPDTRLAWLTETEASA-FDYDPVT---------------GEFFFDRHPGVFAQILNYYRTG 64

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 19354541 118 KLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEAL 162
Cdd:cd18379  65 KLHCPADVCGPLFEEELAFWGIDETQIEPCCWMTYRQHRDAQETL 109

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19354541   229 ARVVAFASLFFILVSITTFCLETHeafnidrnvteihrvgnitsvrFRREVETEPILTYIEGVCVMWFTLEFLVRIVCCP 308
Cdd:pfam00520   1 SRYFELFILLLILLNTIFLALETY----------------------FQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAG 58

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19354541   309 DTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSkaardvLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLL 388
Cdd:pfam00520  59 FKKRYFRSPWNILDFVVVLPSLISLVLSSVGS------LSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNL 132

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19354541   389 IIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGM-------LVGALCA 461
Cdd:pfam00520 133 LLLLLLFLFIFAIIGYQLFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKgefwayiYFVSFII 212

                         250       260
                  ....*....|....*....|....*.
gi 19354541   462 LAGVLTIAMPVPVIVNNFGMYYSLAM 487
Cdd:pfam00520 213 LGGFLLLNLFIAVIIDNFQELTERTE 238

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in voltage-gated potassium (Kv) channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. This family includes several groups of alpha subunits such as KCNA/Kv1 family of Shaker-type Kv channels, KCNB/Kv2 family of Shab-type Kv channels, KCNC/Kv3 family of Shaw-type Kv channels, KCND/Kv4 family of Shal-type Kv channels, KCNF/Kv5 subfamily of Kv channels, KCNG/Kv6 subfamily of Kv channels, KCNV/Kv8 subfamily of Kv channels, and KCNS/Kv9 subfamily of Kv channels. Kv alpha subunits form functional homo- or hetero-tetrameric channels (typically with other alpha subunits from the same subfamily) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. KCNQ/Kv7 channels are not included in this family, since they do not contain a BTB/POZ domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19354541  38 IIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPESDgggagssgssggggggggcEFFFDRHPGVFAYVLNYYRTG 117
Cdd:cd18317   1 VVLNVGGTRFELSRSTLLRFPDTRLGKLAKESHAYDESTN-------------------EYFFDRNPEVFEAILDYYRTG 61

                        90       100
                ....*....|....*....|.
gi 19354541 118 KLHCPADVCGPLFEEELTFWG 138
Cdd:cd18317  62 ELHLPSNVCPASFKEELEFWG 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCND/Kv4 subfamily of Shal-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv4, also known as subfamily D, contains three alpha subunit members, Kv4.1 (KCND1), Kv4.2 (KCND2), and Kv4.3 (KCND3), which are orthologs of the Shal gene in Drosophila. They are A-type potassium channels that mediate the native, fast inactivating (A-type) K+ current (IA) described both in the nervous system (A currents) and the heart (transient outward current). Kv4/KCND subfamily alpha subunits form functional homo- or hetero-tetrameric channels through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. They are modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19354541  37 KIIINVGGTRHETYRSTLRTLPGTRLA-----WLADPDGGgrpesdgggagssgssggggggggcEFFFDRHPGVFAYVL 111
Cdd:cd18380   1 RIVINVSGRRFETWKNTLEKYPDTLLGstekeFFYDDDTK-------------------------EYFFDRDPEIFRHIL 55

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 19354541 112 NYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHR 156
Cdd:cd18380  56 NFYRTGKLHYPRHECISAYDDELAFFGILPEIIGDCCYEDYRDRK 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 2 (KCNB2); KCNB2, also called voltage-gated potassium channel subunit Kv2.2, mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNB2 contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNB2 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19354541  35 SEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDgggrpesdggGAGSSGSSGGGGGGGGCEFFFDRHPGVFAYVLNYY 114
Cdd:cd18412  16 SRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCN----------THESLLEVCDDYNLNENEYFFDRHPGAFTSILNFY 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 19354541 115 RTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHR 156
Cdd:cd18412  86 RTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKK 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily B member 1 (KCNB1); KCNB1, also called delayed rectifier potassium channel 1 (DRK1) or voltage-gated potassium channel subunit Kv2.1, mediates transmembrane potassium transport in excitable membranes, primarily in the brain, but also in the pancreas and cardiovascular system. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNB1 is involved in the regulation of the action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells and endocrine cells and plays a role in homeostatic attenuation of electrical excitability throughout the brain. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNB1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19354541  35 SEKIIINVGGTRHETYRSTLRTLPGTRLAWLadpdgggrpeSDGGGAGSSGSSGGGGGGGGCEFFFDRHPGVFAYVLNYY 114
Cdd:cd18411   9 SRRVKLNVGGLAHEVLWRTLDRLPRTRLGKL----------RDCNTHESLMEICDDYNLEENEYFFDRHPGAFTSILNFY 78

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 19354541 115 RTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTY 152
Cdd:cd18411  79 RTGKLHMMEEMCALSFSQELDYWGIDEIYLESCCQARY 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 3 (KCND3); KCND3, also called voltage-gated potassium channel subunit Kv4.3, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. Mutations in KCND3 cause spinocerebellar ataxia. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND3 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19354541  36 EKIIINVGGTRHETYRSTLRTLPGTRLawladpdggGRPESDGGGAGSSGssggggggggcEFFFDRHPGVFAYVLNYYR 115
Cdd:cd18419  35 ELIVLNVSGRRFQTWRTTLERYPDTLL---------GSTEKEFFFNEDTK-----------EYFFDRDPEVFRCVLNFYR 94

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 19354541 116 TGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHR 156
Cdd:cd18419  95 TGKLHYPRYECISAYDEELAFYGILPEIIGDCCYEEYKDRK 135

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily D member 1 (KCND1); KCND1, also called voltage-gated potassium channel subunit Kv4.1, is a pore-forming subunit of voltage-gated rapidly inactivating A-type potassium channels. It may contribute to I (To) current in heart and I (Sa) current in neurons. Its properties are modulated by interactions with other alpha subunits and with regulatory subunits. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCND1 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv4/KCND alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif. It is modulated by cytoplasmic KChIPs/KCNIPs (Kv-channel interacting proteins), which are small calcium binding proteins with EF-hand-like domains.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19354541  13 RKSGNKPPSKTclkeemaKGEASEKIIINVGGTRHETYRSTLRTLPGTRLawladpdggGRPESDGGGAGSSGssggggg 92
Cdd:cd18417  19 KKPMPKPPSDK-------KRRNDEILVVNVSGRRFQTWKNTLDRYPDTLL---------GSSEKEFFYNEDTQ------- 75

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19354541  93 gggcEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHR 156
Cdd:cd18417  76 ----EYFFDRDPEMFRHILNFYRTGRLHYPRHECIQAFDEELSFYGIIPEIIGDCCLEEYRDRK 135

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNS/Kv9 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv9, also known as subfamily S, includes KCNS1 (Kv9.1), KCNS2 (Kv9.2) and KCNS3 (Kv9.3). They are regulatory alpha subunits that cannot form functional homo-tetrameric channels. Both KCNS1 and KCNS2 are delayed-rectifier K(+) channel alpha subunits that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1) and KCNB2 (also known as Kv2.2), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2. KCNS3 is a delayed-rectifier K(+) channel alpha subunit linked to tissue oxygenation responses. It can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19354541  38 IIINVGGTRHETYRSTLRTLPGTRLAWL--ADPDGGGRPESDGGGAGSSgssggggggggcEFFFDRHPGVFAYVLNYYR 115
Cdd:cd18384   1 IRINVGGFRRRLSASALLRFPGTRLGRLlaCHSEEAILELCDDYDVAAR------------EFYFDRNPGFFLYVLHFYR 68

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 19354541 116 TGKLHCPADVCGPLFEEELTFWGIDETDVEPCCwmTYRQH 155
Cdd:cd18384  69 TGKLHVMDELCVFSFSQEIEYWGINEFFLDSCC--SYRYH 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNG/Kv6 subfamily of potassium voltage-gated channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv6, also known as subfamily G, includes KCNG1 (Kv6.1), KCNG2 (Kv6.2 or KCNF2), KCNG3 (Kv6.3) and KCNG4 (Kv6.4), which are regulatory alpha subunits and do not form functional channels on their own. KCNG1 can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. KCNG2, also called cardiac potassium channel subunit, can form functional heterodimeric channels with KCNB1, and further modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. KCNG3, also called voltage-gated potassium channel subunit Kv10.1, is an electrically silent modulatory subunit that can form functional heterotetrameric channels with KCNB1, and further promotes a reduction in the rate of activation and inactivation of the delayed rectifier voltage-gated potassium channel KCNB1. KCNG4 is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1, and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19354541  38 IIINVGGTRHETYRSTLRTLPGTRLAWLAdpdgGGRPESDGGGAGSSGSSGGGgggggcEFFFDRHPGVFAYVLNYYRTG 117
Cdd:cd18382   1 VIINVGGARYSLPWSTLDRFPLTRLSRLK----ACRSEDDILRVCDDYDVERN------EFFFDRSPEAFGVILLFLRAG 70

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 19354541 118 KLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQ 154
Cdd:cd18382  71 KLRLLREMCALSFQEELAYWGIEEAHLERCCKRRLLR 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily S member 3 (KCNS3); KCNS3, also called delayed-rectifier K(+) channel alpha subunit 3 or voltage-gated potassium channel subunit Kv9.3, is an alpha subunit of voltage-gated potassium channel linked to tissue oxygenation responses. It can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNS3 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19354541  36 EKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDgggrpesdggGAGSSGSSGGGGGGGGCEFFFDRHPGVFAYVLNYYR 115
Cdd:cd18428   1 ELINLNVGGFKQSVDQSTLLRFPHTRLGKLLNCH----------SEEAILELCDDYSVADKEYYFDRNPSLFRYVLNFYY 70

                        90       100       110
                ....*....|....*....|....*....|...
gi 19354541 116 TGKLHCPADVCGPLFEEELTFWGIDETDVEPCC 148
Cdd:cd18428  71 TGKLHVMEELCVFSFCQEIEYWGINELFIDSCC 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G members, KCNG1 and KCNG2; KCNG1, also called voltage-gated potassium channel subunit Kv6.1 or kH2, functions as a regulatory alpha-subunit of voltage-gated potassium channel that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. KCNG2, also called cardiac potassium channel subunit or voltage-gated potassium channel subunit Kv6.2, is a new gamma-subunit of voltage-gated potassium channels that can form functional heterodimeric channels with KCNB1, and further modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG1 and KCNG2 are regulatory alpha subunits and do not form homomultimers. They form heteromultimers (with other alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19354541  38 IIINVGGTRHETYRSTLRTLPGTRLAWLadpdgggrpesDGGGAGSSGSSGGGGGGGGC-EFFFDRHPGVFAYVLNYYRT 116
Cdd:cd18421   6 VIINVGGIKYRIPWTTLEEFPLTRLGQL-----------KSCNNFDEIMDICDDYDVTCnEFFFDRNPCAFRTILTFLRA 74

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 19354541 117 GKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQ 154
Cdd:cd18421  75 GKLRLLREMCALSFQEELLYWGIEEENLEWCCRRRLLQ 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins; The potassium channel tetramerization domain (KCTD) family proteins contain the BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. Some others show Cullin-independent functions including binding and regulation of GABA (gamma-aminobutyric acid) receptors (KCTD8, KCTD12 and KCTD16) and inhibition of AP-2 function (KCTD15). KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19354541  38 IIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPESDGggagssgssggggggggcEFFFDRHPGVFAYVLNYYRTG 117
Cdd:cd18316   1 VKLNVGGTLFTTSRSTLLKDPDSLLAALFSGRWPLPRDEDG------------------SIFIDRDPELFRHILNFLRTG 62

                ....*..
gi 19354541 118 KLHCPAD 124
Cdd:cd18316  63 KLPLPSD 69

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily G member 4 (KCNG4); KCNG4, also called voltage-gated potassium channel subunit Kv6.4, is a silent voltage-gated potassium (KvS) channel subunit that can form functional heterotetrameric channels with KCNB1 (also known as Kv2.1), and further modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNG4 is a regulatory alpha subunit that cannot form a functional homo-tetrameric channel. It forms hetero-tetrameric channels (with other functional alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19354541  36 EKIIINVGGTRHETYRSTLRTLPGTRLAWLA---------------DPDGGgrpesdgggagssgssggggggggcEFFF 100
Cdd:cd18423   2 REIIINVGGIKYLMPWSTLDEFPLTRLGKLKfcssyeeivqicddyDEDTN-------------------------EFFF 56

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 19354541 101 DRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCC 148
Cdd:cd18423  57 DRNPCAFRMIVSFLAAGKLRLLREMCALSFQEELTYWGIEEANLERCC 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 7 (KCNA7); KCNA7, also called voltage-gated potassium channel subunit Kv1.7, mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA7 plays an important role in the repolarization of cell membranes. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA7 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19354541  36 EKIIINVGGTRHETYRSTLRTLPGTrlaWLADPDGGGRPESDGGGagssgssggggggggcEFFFDRHPGVFAYVLNYYR 115
Cdd:cd18408   6 ERVVLNVAGLRFETRARTLGRFPDT---LLGDPARRGRFYDDRRR----------------EYFFDRHRPSFDAVLYYYQ 66

                        90       100
                ....*....|....*....|....*..
gi 19354541 116 T-GKLHCPADVCGPLFEEELTFWGIDE 141
Cdd:cd18408  67 SgGRLRRPAHVPLDVFLEEVAFYGLGA 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNA/Kv1 subfamily of Shaker-type voltage-dependent potassium channels; Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. The potassium voltage-gated channel subfamily Kv1, also known as subfamily A, contains eight alpha subunit members, Kv1.1 (KCNA1), Kv1.2 (KCNA2), Kv1.3 (KCNA3), Kv1.4 (KCNA4), Kv1.5 (KCNA5), Kv1.6 (KCNA6), Kv1.7 (KCNA7), and Kv1.8 (KCNA10), which are orthologs of the Shaker gene in Drosophila. They are delayed rectifiers except for Kv1.4 (KCNA4), which is an A-type potassium channel. Delayed rectifiers are slow opening and closing voltage-gated potassium channels. Because of their delayed activation kinetics, they play an important role in controlling action potential duration. A-type channels are fast/rapidly inactivating potassium channels. Kv1/KCNA subfamily alpha subunits form functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19354541  36 EKIIINVGGTRHETYRSTLRTLPGTrlaWLADPDGGGR---PESDgggagssgssggggggggcEFFFDRHPGVFAYVLN 112
Cdd:cd18377   1 ERVVINVSGLRFETQLKTLAQFPNT---LLGDPNKRMRffdPLRN-------------------EYFFDRNRPSFDAILY 58

                        90       100
                ....*....|....*....|....*.
gi 19354541 113 YYRT-GKLHCPADVCGPLFEEELTFW 137
Cdd:cd18377  59 YYQSgGRLRRPVNVPLDIFLEEIRFY 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel regulatory protein (KCNRG); KCNRG, also called potassium channel regulator or protein CLLD4, is an endoplasmic reticulum (ER)-associated tumor suppressor that regulates Kv1 family potassium channel proteins by retaining a fraction of the channels in endomembranes. It contains a BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19354541  36 EKIIINVGGTRHETYRSTLRTLPGTRLAWLADpdgGGRPEsdgggagssgssgggGGGGGCEFFFDRHPGVFAYVLNYYR 115
Cdd:cd18375   1 ELVTLNVGGKKFTTRPSTLRRFPDSRLARMLD---GKDQD---------------FKVVNGQFFVDRDGSLFSYILDYLR 62

                ....*....
gi 19354541 116 TGKLHCPAD 124
Cdd:cd18375  63 TGQLTLPTE 71

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A members 2 (KCNA2) and 3 (KCNA3); KCNA2 is also called NGK1, voltage-gated K(+) channel HuKIV, voltage-gated potassium channel HBK5, or voltage-gated potassium channel subunit Kv1.2. KCNA3 is also called HGK5, HLK3, HPCN3, voltage-gated K(+) channel HuKIII, or voltage-gated potassium channel subunit Kv1.3. KCNA2 and KCNA3 mediate transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. KCNA2 primarily functions in the brain and the central nervous system, but also in the cardiovascular system. It prevents aberrant action potential firing and regulates neuronal output. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA2 and KCNA3 are alpha subunits that form functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through their BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19354541  36 EKIIINVGGTRHETYRSTLRTLPGTrlaWLADPDGGGR---PESDgggagssgssggggggggcEFFFDRHPGVFAYVLN 112
Cdd:cd18403   1 ERVVINISGLRFETQLKTLAQFPET---LLGDPKKRMRyfdPLRN-------------------EYFFDRNRPSFDAILY 58

                        90       100       110
                ....*....|....*....|....*....|....
gi 19354541 113 YYRT-GKLHCPADVCGPLFEEELTFWGIDETDVE 145
Cdd:cd18403  59 YYQSgGRLRRPVNVPLDIFSEEIRFYELGEEAME 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 4 (KCNA4); KCNA4 is also called HPCN2, or voltage-gated K(+) channel HuKII, voltage-gated potassium channel HBK4, voltage-gated potassium channel HK1, or voltage-gated potassium channel subunit Kv1.4. It mediates transmembrane potassium transport in excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a tetrameric potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Voltage-gated potassium (Kv) channels are composed of alpha subunits, which form the actual conductance pore, and cytoplasmic beta subunits, which are auxiliary proteins that associate with alpha subunits to modulate the activity of the Kv channel. KCNA4 is an alpha subunit that forms functional homo- or hetero-tetrameric channels (with other Kv1/KCNA alpha subunits) through its BTB/POZ domain, also known as tetramerization (T1) domain, which is a versatile protein-protein interaction motif.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19354541  36 EKIIINVGGTRHETYRSTLRTLPGTrlaWLADPDGGGR---PESDgggagssgssggggggggcEFFFDRHPGVFAYVLN 112
Cdd:cd18405   1 ERVVINVSGLRFETQLKTLAQFPET---LLGDPEKRMRyfdPLRN-------------------EYFFDRNRPSFDAILY 58

                        90       100       110
                ....*....|....*....|....*....|
gi 19354541 113 YYRT-GKLHCPADVCGPLFEEELTFWGIDE 141
Cdd:cd18405  59 YYQSgGRLKRPVNVPFDIFSEEVKFYELGE 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3) and SH3KBP1-binding protein 1 (SHKBP1); The group of KCTD proteins includes KCTD3 and SHKBP1. KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. SHKBP1, also called SETA-binding protein 1, interacts with cathepsin B and participates in tumor necrosis factor (TNF)-induced apoptosis in ovarian cancer cells. It can promote epidermal growth factor receptor (EGFR) signaling by interrupting c-Cbl-CIN85 complex and inhibiting EGFR degradation. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19354541  35 SEKIIINVGGTRHETYRSTLRTLPGT--------RLAWLADPDGGgrpesdgggagssgssggggggggceFFFDRHPGV 106
Cdd:cd18363   1 GDIINLNVGGKRFSTSRQTLTWIPDSfftsllsgRISSLKDETGA--------------------------IFIDRDPKL 54

                        90       100       110
                ....*....|....*....|....*....|....
gi 19354541 107 FAYVLNYYRTGKLH-CPADVCGPLFEEEltFWGI 139
Cdd:cd18363  55 FSIILNYLRTKEIDlRNVDISSLRHEAE--FYGI 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 14 (KCTD14); KCTD14 is a BTB/POZ domain-containing protein with unknown biological function. KCTD proteins play crucial roles in a variety of fundamental biological processes, such as protein ubiquitination and degradation, suppression of proliferation or transcription, cytoskeleton regulation, tetramerization and gating of ion channels and others. Some KCTD proteins are involved in protein ubiquitination as part of the CRL (Cullin RING Ligase) E3 ligases. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19354541  35 SEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPESDGggagssgssggggggggcEFFFDRHPGVFAYVLNYY 114
Cdd:cd18371   1 SQVVSLNVGGHIYTTTLSTLRKFPGSKLAELFNGQPKLRTDSEG------------------RYFIDRDGTYFRYILEYL 62

                        90       100       110
                ....*....|....*....|....*....|..
gi 19354541 115 RTGKLhcPADVCGPLFEEELTFwgidetDVEP 146
Cdd:cd18371  63 RTNQV--PTQHIQEVYKEALFY------DIEP 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 3 (KCTD3); KCTD3, also called renal carcinoma antigen NY-REN-45, is a BTB/POZ domain-containing protein that is an accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3), upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19354541  36 EKIIINVGGTRHETYRSTLRTLPGT--------RLAWLADPDGGgrpesdgggagssgssggggggggceFFFDRHPGVF 107
Cdd:cd18392   2 EIIQLNVGGTRFSTSRQTLMWIPDSffssllsgRISSLKDETGA--------------------------IFIDRDPTAF 55

                        90       100       110
                ....*....|....*....|....*....|..
gi 19354541 108 AYVLNYYRTGKLHcPADVCGPLFEEELTFWGI 139
Cdd:cd18392  56 VPILNFLRTKELD-LRGVNINVLRHEAEFYGI 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing proteins, KCTD1 and KCTD15; This subfamily of KCTD proteins includes KCTD1 and KCTD15. KCTD1 is a nuclear BTB/POZ domain-containing protein that acts as a transcriptional repressor and mediates protein-protein interactions through a BTB domain. It represses the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C. It also functions as a novel inhibitor of the Wnt signaling pathway. Mutations in KCTD1 cause scalp-ear-nipple (SEN) syndrome. KCTD15 is a BTB/POZ domain-containing protein that plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interaction with its activation domain. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains form pentamers.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19354541  40 INVGGTrheTYRSTLRTL---PGTRLAWLADpdgGGRPesdgggagssgssgGGGGGGGCEFFFDRHPGVFAYVLNYYRT 116
Cdd:cd18361   3 IDVGGH---IYTSSLETLtkyPESRLGKLFN---GSIP--------------IVLDSLKQHYFIDRDGKMFRHILNFLRT 62

                        90       100
                ....*....|....*....|....*.
gi 19354541 117 GKLHCPADVCG-PLFEEELTFWGIDE 141
Cdd:cd18361  63 SKLLLPDDFTEfDLLYEEARYYELQP 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium channel tetramerization domain-containing protein 5 (KCTD5); KCTD5 is a BTB/POZ domain-containing protein that functions as a substrate adaptor for cullin3 based ubiquitin E3 ligases. It is a negative regulator of the AKT pathway, a key signaling cascade frequently deregulated in cancer. KCTD5 does not impact the operation of Kv4.2, Kv3.4, Kv2.1, or Kv1.2 channels. The BTB/POZ domain, also known as tetramerization (T1) domain, is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. KCTD family BTB domains can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. KCTD5 forms pentamers mediated by its BTB domain.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19354541  32 GEASEKIIINVGGTRHETYRSTLRTLPGTRLAWL--ADPDgggrPESDGGGAGSsgssggggggggceFFFDRHPGVFAY 109
Cdd:cd18390   1 GGVSKWVRLNVGGTYFLTTRQTLCRDPKSFLYRLcqADPD----LDSDKDETGA--------------YLIDRDPTYFGP 62

                        90       100       110
                ....*....|....*....|....*....|
gi 19354541 110 VLNYYRTGKLHCPADVCGPLFEEELTFWGI 139
Cdd:cd18390  63 VLNYLRHGKLVINKDLAEEGVLEEAEFYNI 92