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Conserved domains on  [gi|1935028422|ref|XP_027675125|]
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elongation of very long chain fatty acids protein 4 isoform X1 [Chelonia mydas]

Protein Classification

elongation of very long chain fatty acids protein( domain architecture ID 10471715)

elongation of very long chain fatty acids protein catalyzes the first and rate-limiting reaction of the four steps that constitute the long-chain fatty acids elongation cycle

EC:  2.3.1.199
Gene Ontology:  GO:0009922|GO:0042761

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ELO pfam01151
GNS1/SUR4 family; Members of this family are involved in long chain fatty acid elongation ...
36-272 5.15e-71

GNS1/SUR4 family; Members of this family are involved in long chain fatty acid elongation systems that produce the 26-carbon precursors for ceramide and sphingolipid synthesis. Predicted to be integral membrane proteins, in eukaryotes they are probably located on the endoplasmic reticulum. Yeast ELO3 affects plasma membrane H+-ATPase activity, and may act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1.


:

Pssm-ID: 460083  Cd Length: 242  Bit Score: 218.64  E-value: 5.15e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935028422  36 LLVYSPLPVTLLFTLYLVFVALGPRLMRKREPLRLKGLLTAYNLTLVALSIYMFYEFLVTSVLANYSYLCQPVDYTQSKL 115
Cdd:pfam01151   1 PLLSSPDPVILIIVLYLLFVFLGPKLMRNRKPFDLRRLLIVYNLFLSLFSLYGFYGMLPALLGWLYGFFWSLCQPSESPF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935028422 116 GMRMARV-CWWFFFSKVIELLDTVFFILRKKpeQVTFLHVYHHGTMLFNWWAGVKYVPGGQAFFIGMLNSFVHIFMYLYY 194
Cdd:pfam01151  81 AQGLVGFwYYLFYLSKILELLDTVFLVLRKK--QLSFLHVYHHSTMLLYSWLGYKYGTGGVGWFFILLNSFVHVIMYFYY 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935028422 195 GLASLGpqmQRYL--WWKRYLTILQLCQFVAIAVHSSYNLFT------ECPFPDGFNIAVFLYILSLIVLFLNFYYWTYT 266
Cdd:pfam01151 159 FLAALG---NKKLprWWKKYITQLQILQFVIGLAHTVYALYQyylgpyGCDGPRFAARLGLVMYLSYLFLFSNFYIKSYL 235

                  ....*.
gi 1935028422 267 RGKWEK 272
Cdd:pfam01151 236 KPKKKK 241
 
Name Accession Description Interval E-value
ELO pfam01151
GNS1/SUR4 family; Members of this family are involved in long chain fatty acid elongation ...
36-272 5.15e-71

GNS1/SUR4 family; Members of this family are involved in long chain fatty acid elongation systems that produce the 26-carbon precursors for ceramide and sphingolipid synthesis. Predicted to be integral membrane proteins, in eukaryotes they are probably located on the endoplasmic reticulum. Yeast ELO3 affects plasma membrane H+-ATPase activity, and may act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1.


Pssm-ID: 460083  Cd Length: 242  Bit Score: 218.64  E-value: 5.15e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935028422  36 LLVYSPLPVTLLFTLYLVFVALGPRLMRKREPLRLKGLLTAYNLTLVALSIYMFYEFLVTSVLANYSYLCQPVDYTQSKL 115
Cdd:pfam01151   1 PLLSSPDPVILIIVLYLLFVFLGPKLMRNRKPFDLRRLLIVYNLFLSLFSLYGFYGMLPALLGWLYGFFWSLCQPSESPF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935028422 116 GMRMARV-CWWFFFSKVIELLDTVFFILRKKpeQVTFLHVYHHGTMLFNWWAGVKYVPGGQAFFIGMLNSFVHIFMYLYY 194
Cdd:pfam01151  81 AQGLVGFwYYLFYLSKILELLDTVFLVLRKK--QLSFLHVYHHSTMLLYSWLGYKYGTGGVGWFFILLNSFVHVIMYFYY 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935028422 195 GLASLGpqmQRYL--WWKRYLTILQLCQFVAIAVHSSYNLFT------ECPFPDGFNIAVFLYILSLIVLFLNFYYWTYT 266
Cdd:pfam01151 159 FLAALG---NKKLprWWKKYITQLQILQFVIGLAHTVYALYQyylgpyGCDGPRFAARLGLVMYLSYLFLFSNFYIKSYL 235

                  ....*.
gi 1935028422 267 RGKWEK 272
Cdd:pfam01151 236 KPKKKK 241
PTZ00251 PTZ00251
fatty acid elongase; Provisional
51-230 1.41e-07

fatty acid elongase; Provisional


Pssm-ID: 140278  Cd Length: 272  Bit Score: 51.39  E-value: 1.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935028422  51 YLVFVALGPRLM----RKREPLRL-KGLLTAYNLTLVALSIYMFYEF--LVTSVLANYSY---LC--QPVDYTQSKLGMR 118
Cdd:PTZ00251   35 YLTFVFKGPQLVdaifHGNPPVPLiKKCWALWNIGLSVFSMYGVYRVvpPLLNNLRKYGLhdtLCtfREDEFYTGKVGVA 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935028422 119 MArvcwWFFFSKVIELLDTVFFILRKKpeQVTFLHVYHHGTM-LFNWWAgvkYVPGGQAFFI-GMLNSFVHIFMYLYYGL 196
Cdd:PTZ00251  115 MG----LFSISKVPEFGDTFFLIMGGK--KLPFLSWFHHVTIfLYAWMS---YQQGSSIWICaAAMNYFVHSIMYFYFAL 185
                         170       180       190
                  ....*....|....*....|....*....|....
gi 1935028422 197 ASLGPQmQRYLWWKRYLTILQLCQFVAIAVHSSY 230
Cdd:PTZ00251  186 SEAGFK-KLVKPFAMYITLLQITQMVGGLFVSGY 218
 
Name Accession Description Interval E-value
ELO pfam01151
GNS1/SUR4 family; Members of this family are involved in long chain fatty acid elongation ...
36-272 5.15e-71

GNS1/SUR4 family; Members of this family are involved in long chain fatty acid elongation systems that produce the 26-carbon precursors for ceramide and sphingolipid synthesis. Predicted to be integral membrane proteins, in eukaryotes they are probably located on the endoplasmic reticulum. Yeast ELO3 affects plasma membrane H+-ATPase activity, and may act on a glucose-signaling pathway that controls the expression of several genes that are transcriptionally regulated by glucose such as PMA1.


Pssm-ID: 460083  Cd Length: 242  Bit Score: 218.64  E-value: 5.15e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935028422  36 LLVYSPLPVTLLFTLYLVFVALGPRLMRKREPLRLKGLLTAYNLTLVALSIYMFYEFLVTSVLANYSYLCQPVDYTQSKL 115
Cdd:pfam01151   1 PLLSSPDPVILIIVLYLLFVFLGPKLMRNRKPFDLRRLLIVYNLFLSLFSLYGFYGMLPALLGWLYGFFWSLCQPSESPF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935028422 116 GMRMARV-CWWFFFSKVIELLDTVFFILRKKpeQVTFLHVYHHGTMLFNWWAGVKYVPGGQAFFIGMLNSFVHIFMYLYY 194
Cdd:pfam01151  81 AQGLVGFwYYLFYLSKILELLDTVFLVLRKK--QLSFLHVYHHSTMLLYSWLGYKYGTGGVGWFFILLNSFVHVIMYFYY 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935028422 195 GLASLGpqmQRYL--WWKRYLTILQLCQFVAIAVHSSYNLFT------ECPFPDGFNIAVFLYILSLIVLFLNFYYWTYT 266
Cdd:pfam01151 159 FLAALG---NKKLprWWKKYITQLQILQFVIGLAHTVYALYQyylgpyGCDGPRFAARLGLVMYLSYLFLFSNFYIKSYL 235

                  ....*.
gi 1935028422 267 RGKWEK 272
Cdd:pfam01151 236 KPKKKK 241
PTZ00251 PTZ00251
fatty acid elongase; Provisional
51-230 1.41e-07

fatty acid elongase; Provisional


Pssm-ID: 140278  Cd Length: 272  Bit Score: 51.39  E-value: 1.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935028422  51 YLVFVALGPRLM----RKREPLRL-KGLLTAYNLTLVALSIYMFYEF--LVTSVLANYSY---LC--QPVDYTQSKLGMR 118
Cdd:PTZ00251   35 YLTFVFKGPQLVdaifHGNPPVPLiKKCWALWNIGLSVFSMYGVYRVvpPLLNNLRKYGLhdtLCtfREDEFYTGKVGVA 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1935028422 119 MArvcwWFFFSKVIELLDTVFFILRKKpeQVTFLHVYHHGTM-LFNWWAgvkYVPGGQAFFI-GMLNSFVHIFMYLYYGL 196
Cdd:PTZ00251  115 MG----LFSISKVPEFGDTFFLIMGGK--KLPFLSWFHHVTIfLYAWMS---YQQGSSIWICaAAMNYFVHSIMYFYFAL 185
                         170       180       190
                  ....*....|....*....|....*....|....
gi 1935028422 197 ASLGPQmQRYLWWKRYLTILQLCQFVAIAVHSSY 230
Cdd:PTZ00251  186 SEAGFK-KLVKPFAMYITLLQITQMVGGLFVSGY 218
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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