endolytic transglycosylase MltG functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, ...
48-229
3.47e-03
LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, are LPXTG-anchored large surface proteins that contribute to virulence. Several closely related paralogs may be found in a single strain.
The actual alignment was detected with superfamily member NF033875:
Pssm-ID: 411439 [Multi-domain] Cd Length: 1306 Bit Score: 40.85 E-value: 3.47e-03
YceG-like family; This family of proteins is found in bacteria. Proteins in this family are ...
329-648
1.14e-101
YceG-like family; This family of proteins is found in bacteria. Proteins in this family are typically between 332 and 389 amino acids in length. This family was previously incorrectly annotated and names as aminodeoxychorismate lyase. The structure of Swiss:P28306 was solved by X-ray crystallography.
Pssm-ID: 460622 Cd Length: 273 Bit Score: 310.99 E-value: 1.14e-101
proteins similar to Escherichia coli YceG/mltG may function as endolytic murein ...
368-647
1.30e-93
proteins similar to Escherichia coli YceG/mltG may function as endolytic murein transglycosylases; The gene product of Escherichia coli yceG/mltG has been erroneously annotated as an aminodeoxychorismate lyase. Its overexpression has been reported to cause abnormal biofilm architecture, and it has been reported to be part of a putative five-gene operon. More recently it has been proposed to function as a terminase for peptidoglycan polymerization. The family also includes Streptomyces caeruleus NovB, an uncharacterized member of the novobiocin biosynthetic gene cluster.
Pssm-ID: 381750 Cd Length: 246 Bit Score: 289.13 E-value: 1.30e-93
conserved hypothetical protein, YceG family; This uncharacterized protein family, found in ...
321-658
3.59e-56
conserved hypothetical protein, YceG family; This uncharacterized protein family, found in three of four microbial genomes, virtually always once per genome, includes YceG from Escherichia coli. This protein is encoded next to PabC, 4-amino-4-deoxychorismate lyase, in E. coli and numerous other proteobacteria, but that proximity is not conserved in other lineages. Numerous members of this family have been misannotated as aminodeoxychorismate lyase, apparently because of promiximty to PabC. [Hypothetical proteins, Conserved]
Pssm-ID: 272983 Cd Length: 342 Bit Score: 194.29 E-value: 3.59e-56
LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, ...
48-229
3.47e-03
LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, are LPXTG-anchored large surface proteins that contribute to virulence. Several closely related paralogs may be found in a single strain.
Pssm-ID: 411439 [Multi-domain] Cd Length: 1306 Bit Score: 40.85 E-value: 3.47e-03
YceG-like family; This family of proteins is found in bacteria. Proteins in this family are ...
329-648
1.14e-101
YceG-like family; This family of proteins is found in bacteria. Proteins in this family are typically between 332 and 389 amino acids in length. This family was previously incorrectly annotated and names as aminodeoxychorismate lyase. The structure of Swiss:P28306 was solved by X-ray crystallography.
Pssm-ID: 460622 Cd Length: 273 Bit Score: 310.99 E-value: 1.14e-101
proteins similar to Escherichia coli YceG/mltG may function as endolytic murein ...
368-647
1.30e-93
proteins similar to Escherichia coli YceG/mltG may function as endolytic murein transglycosylases; The gene product of Escherichia coli yceG/mltG has been erroneously annotated as an aminodeoxychorismate lyase. Its overexpression has been reported to cause abnormal biofilm architecture, and it has been reported to be part of a putative five-gene operon. More recently it has been proposed to function as a terminase for peptidoglycan polymerization. The family also includes Streptomyces caeruleus NovB, an uncharacterized member of the novobiocin biosynthetic gene cluster.
Pssm-ID: 381750 Cd Length: 246 Bit Score: 289.13 E-value: 1.30e-93
conserved hypothetical protein, YceG family; This uncharacterized protein family, found in ...
321-658
3.59e-56
conserved hypothetical protein, YceG family; This uncharacterized protein family, found in three of four microbial genomes, virtually always once per genome, includes YceG from Escherichia coli. This protein is encoded next to PabC, 4-amino-4-deoxychorismate lyase, in E. coli and numerous other proteobacteria, but that proximity is not conserved in other lineages. Numerous members of this family have been misannotated as aminodeoxychorismate lyase, apparently because of promiximty to PabC. [Hypothetical proteins, Conserved]
Pssm-ID: 272983 Cd Length: 342 Bit Score: 194.29 E-value: 3.59e-56
LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, ...
48-229
3.47e-03
LPXTG-anchored aggregation substance; Aggregation substances, as described in Enterococcus, are LPXTG-anchored large surface proteins that contribute to virulence. Several closely related paralogs may be found in a single strain.
Pssm-ID: 411439 [Multi-domain] Cd Length: 1306 Bit Score: 40.85 E-value: 3.47e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
or click on the triangles, if present, that represent functional sites (conserved features)
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
(labeled illustration) Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance.
(labeled illustration) Four types of hits can be shown, as available,
for each region on the query sequence:
specific hits meet or exceed a domain-specific e-value threshold
(illustrated example)
and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits
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Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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