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Conserved domains on  [gi|1931703409|gb|QPB74035|]
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IC9-Luc90-CD828Z [synthetic construct]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CASc cd00032
Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent ...
 136-398 1.20e-103

Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide backbone adjacent to an aspartate. The resulting two subunits associate to form an (alpha)2(beta)2-tetramer which is the active enzyme. Activation of caspases can be mediated by other caspase homologs.


:

Pssm-ID: 237997  Cd Length: 243  Bit Score: 321.86  E-value: 1.20e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 136 AYILSMEPCGHCLIINNVNFCResGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCV 215
Cdd:cd00032     1 IYKMNSKRRGLALIINNENFDK--GLKDRDGTDVDAENLTKLFESLGYEVEVKNNLTAEEILEELKEFASPDHSDSDSFV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 216 VVILSHGCQashlqfpGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSN 295
Cdd:cd00032    79 CVILSHGEE-------GGIYGTDGDVVPIDEITSLFNGDNCPSLAGKPKLFFIQACRGDELDLGVEVDSGADEPPDVETE 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 296 PEPdatpfqeglrtfdqlDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAV 375
Cdd:cd00032   152 AED---------------DAVQTIPVEADFLVAYSTVPGYVSWRNTKKGSWFIQSLCQVLRKYAHSLDLLDILTKVNRKV 216

                         250       260
                  ....*....|....*....|....*..
gi 1931703409 376 SVK----GIYKQMPGCFNFLRKKLFFK 398
Cdd:cd00032   217 AEKfesvNGKKQMPCFRSTLTKKLYFF 243
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
 571-687 1.79e-64

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


:

Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 212.17  E-value: 1.79e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 571 QLQQPGAELVRPGASVKLSCKASGYSFTTYWMNWVKQRPGQGLEWIGMIHPSDSETRLNQKFKDKATLTVDKSSSTAYMQ 650
Cdd:cd04981     1 QLQESGPGLVKPGQSLKLSCKASGFTFTSYGMGWVRQAPGKGLEWIGLIYPGGGDTYYADSFKGRFTITRDTSKSTAYLQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1931703409 651 LSSPTSEDSAVYYCARSTMIAT-RAMDYWGQGTSVTVS 687
Cdd:cd04981    81 LNSLTSEDTAVYYCARGLGGYGySYFDYWGQGTTVTVS 118
IgV_L_kappa cd04980
Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are ...
 445-549 2.77e-60

Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, kappa type, variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.


:

Pssm-ID: 409369  Cd Length: 106  Bit Score: 200.31  E-value: 2.77e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 445 IVMTQSQKSMSTSVGDRVSITCKASQDVI-TGVAWYQQKPGQSPKLLIYSASYRYTGVPDRFTGSGSGTDFTFTISNVQA 523
Cdd:cd04980     1 IVMTQSPASLSVSPGERVTISCKASQSISsNYLAWYQQKPGQAPKLLIYYASTLHSGVPSRFSGSGSGTDFTLTISSVEP 80

                          90       100
                  ....*....|....*....|....*.
gi 1931703409 524 EDLAVYYCQQHYSTPLTFGAGTKLEL 549
Cdd:cd04980    81 EDAAVYYCQQGYTFPYTFGGGTKLEI 106
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 5-108 5.05e-43

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 151.49  E-value: 5.05e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409   5 VQVETISPGDGRTfPKRGQTCVVHYTGMLEDGKKVDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYA 84
Cdd:COG0545     1 LQYKVLKEGTGAK-PKAGDTVTVHYTGTLLDGTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELA 79

                          90       100
                  ....*....|....*....|....
gi 1931703409  85 YGATGHPGIIPPHATLVFDVELLK 108
Cdd:COG0545    80 YGERGAGGVIPPNSTLVFEVELLD 103
ITAM smart00077
Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on ...
 830-850 1.69e-04

Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery.


:

Pssm-ID: 128390  Cd Length: 21  Bit Score: 39.29  E-value: 1.69e-04
                           10        20
                   ....*....|....*....|.
gi 1931703409  830 NQLYNELNLGRREEYDVLDKR 850
Cdd:smart00077   1 DQLYQPLNKRQRDTYSDLNTR 21
ITAM smart00077
Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on ...
 899-919 7.20e-04

Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery.


:

Pssm-ID: 128390  Cd Length: 21  Bit Score: 37.36  E-value: 7.20e-04
                           10        20
                   ....*....|....*....|.
gi 1931703409  899 DGLYQGLSTATKDTYDALHMQ 919
Cdd:smart00077   1 DQLYQPLNKRQRDTYSDLNTR 21
 
Name Accession Description Interval E-value
CASc cd00032
Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent ...
 136-398 1.20e-103

Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide backbone adjacent to an aspartate. The resulting two subunits associate to form an (alpha)2(beta)2-tetramer which is the active enzyme. Activation of caspases can be mediated by other caspase homologs.


Pssm-ID: 237997  Cd Length: 243  Bit Score: 321.86  E-value: 1.20e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 136 AYILSMEPCGHCLIINNVNFCResGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCV 215
Cdd:cd00032     1 IYKMNSKRRGLALIINNENFDK--GLKDRDGTDVDAENLTKLFESLGYEVEVKNNLTAEEILEELKEFASPDHSDSDSFV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 216 VVILSHGCQashlqfpGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSN 295
Cdd:cd00032    79 CVILSHGEE-------GGIYGTDGDVVPIDEITSLFNGDNCPSLAGKPKLFFIQACRGDELDLGVEVDSGADEPPDVETE 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 296 PEPdatpfqeglrtfdqlDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAV 375
Cdd:cd00032   152 AED---------------DAVQTIPVEADFLVAYSTVPGYVSWRNTKKGSWFIQSLCQVLRKYAHSLDLLDILTKVNRKV 216

                         250       260
                  ....*....|....*....|....*..
gi 1931703409 376 SVK----GIYKQMPGCFNFLRKKLFFK 398
Cdd:cd00032   217 AEKfesvNGKKQMPCFRSTLTKKLYFF 243
CASc smart00115
Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine aspartases that ...
 137-397 7.50e-98

Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine aspartases that mediate programmed cell death (apoptosis). Caspases are synthesised as zymogens and activated by proteolysis of the peptide backbone adjacent to an aspartate. The resulting two subunits associate to form an (alpha)2(beta)2-tetramer which is the active enzyme. Activation of caspases can be mediated by other caspase homologues.


Pssm-ID: 214521  Cd Length: 241  Bit Score: 306.47  E-value: 7.50e-98
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409  137 YILSMEPCGHCLIINNVNFCResgLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQ-QDHGALDCCV 215
Cdd:smart00115   1 YKMNSKPRGLALIINNENFHS---LPRRNGTDVDAENLTELFQSLGYEVQVKNNLTAEEMLEELKEFAAmPEHSDSDSFV 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409  216 VVILSHGcqashlqFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGsn 295
Cdd:smart00115  78 CVLLSHG-------EEGGIYGTDGDPLPLDEIFSLFNGDNCPSLAGKPKLFFIQACRGDELDGGVPVEDSVADPESEG-- 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409  296 pepdatpfqeglrtfdQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAV 375
Cdd:smart00115 149 ----------------EDDAIYKIPVEADFLAAYSTTPGYVSWRNPTRGSWFIQSLCQVLKEYARSLDLLDILTEVNRKV 212

                          250       260
                   ....*....|....*....|....*..
gi 1931703409  376 SVKGIY----KQMPGCFNF-LRKKLFF 397
Cdd:smart00115 213 ADKFESvnakKQMPTIESMtLTKKLYF 239
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
 571-687 1.79e-64

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 212.17  E-value: 1.79e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 571 QLQQPGAELVRPGASVKLSCKASGYSFTTYWMNWVKQRPGQGLEWIGMIHPSDSETRLNQKFKDKATLTVDKSSSTAYMQ 650
Cdd:cd04981     1 QLQESGPGLVKPGQSLKLSCKASGFTFTSYGMGWVRQAPGKGLEWIGLIYPGGGDTYYADSFKGRFTITRDTSKSTAYLQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1931703409 651 LSSPTSEDSAVYYCARSTMIAT-RAMDYWGQGTSVTVS 687
Cdd:cd04981    81 LNSLTSEDTAVYYCARGLGGYGySYFDYWGQGTTVTVS 118
Peptidase_C14 pfam00656
Caspase domain;
145-396 5.63e-63

Caspase domain;


Pssm-ID: 425803  Cd Length: 213  Bit Score: 211.80  E-value: 5.63e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 145 GHCLIINNVNFCRESglRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQ-QDHGALDCCVVVIL---S 220
Cdd:pfam00656   2 GLALIIGNNNYPGTK--APLRGCDNDAEALAKTLKSLGFEVRVFEDLTAEEIRRALRDFAArADHSDGDSFVVVLLyysG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 221 HGCQashlQFPGAVYGTDGCPVSVEKIVNIFNGTSC-PSLGGKPKLFFIQACGGEQKDHGfevastspedespgsnpepd 299
Cdd:pfam00656  80 HGEQ----VPGGDIYGTDEYLVPVDALTNLFTGDDClPSLVGKPKLFIIDACRGNLEDGG-------------------- 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 300 atpfqeglrtfdqldaisslPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKG 379
Cdd:pfam00656 136 --------------------VVEADFLVAYSTAPGQVSWRNTGSGSWFIQALCQVLREYGHGLDLLSLLTKVRRRVAEAT 195

                         250
                  ....*....|....*...
gi 1931703409 380 IYKQMPGCF-NFLRKKLF 396
Cdd:pfam00656 196 GKKQMPCLSsSTLTKKFY 213
IgV_L_kappa cd04980
Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are ...
 445-549 2.77e-60

Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, kappa type, variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.


Pssm-ID: 409369  Cd Length: 106  Bit Score: 200.31  E-value: 2.77e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 445 IVMTQSQKSMSTSVGDRVSITCKASQDVI-TGVAWYQQKPGQSPKLLIYSASYRYTGVPDRFTGSGSGTDFTFTISNVQA 523
Cdd:cd04980     1 IVMTQSPASLSVSPGERVTISCKASQSISsNYLAWYQQKPGQAPKLLIYYASTLHSGVPSRFSGSGSGTDFTLTISSVEP 80

                          90       100
                  ....*....|....*....|....*.
gi 1931703409 524 EDLAVYYCQQHYSTPLTFGAGTKLEL 549
Cdd:cd04980    81 EDAAVYYCQQGYTFPYTFGGGTKLEI 106
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 5-108 5.05e-43

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 151.49  E-value: 5.05e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409   5 VQVETISPGDGRTfPKRGQTCVVHYTGMLEDGKKVDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYA 84
Cdd:COG0545     1 LQYKVLKEGTGAK-PKAGDTVTVHYTGTLLDGTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELA 79

                          90       100
                  ....*....|....*....|....
gi 1931703409  85 YGATGHPGIIPPHATLVFDVELLK 108
Cdd:COG0545    80 YGERGAGGVIPPNSTLVFEVELLD 103
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
15-107 6.51e-42

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 148.11  E-value: 6.51e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409  15 GRTFPKRGQTCVVHYTGMLEDGKKVDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGH-PGI 93
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLaGPV 80

                          90
                  ....*....|....
gi 1931703409  94 IPPHATLVFDVELL 107
Cdd:pfam00254  81 IPPNATLVFEVELL 94
IGv smart00406
Immunoglobulin V-Type;
585-666 2.31e-27

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 105.93  E-value: 2.31e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409  585 SVKLSCKASGYSFTTYWMNWVKQRPGQGLEWIGMIhPSDSETRLNQKFKDKATLTVDKSSSTAYMQLSSPTSEDSAVYYC 664
Cdd:smart00406   1 SVTLSCKFSGSTFSSYYVSWVRQPPGKGLEWLGYI-GSNGSSYYQESYKGRFTISKDTSKNDVSLTISNLRVEDTGTYYC 79


                   ..
gi 1931703409  665 AR 666
Cdd:smart00406  80 AV 81
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 6-110 5.50e-24

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 102.53  E-value: 5.50e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409   6 QVEtiSPGDGRTfPKRGQTCVVHYTGMLEDGKKVDSSRDRNKPFKFMLgkQEVIRGWEEGVAQMSVGQRAKLTISPDYAY 85
Cdd:PRK10902  151 KVE--KEGTGEA-PKDSDTVVVNYKGTLIDGKEFDNSYTRGEPLSFRL--DGVIPGWTEGLKNIKKGGKIKLVIPPELAY 225

                          90       100
                  ....*....|....*....|....*
gi 1931703409  86 GATGHPGiIPPHATLVFDVELLKLE 110
Cdd:PRK10902  226 GKAGVPG-IPANSTLVFDVELLDVK 249
IGv smart00406
Immunoglobulin V-Type;
462-533 3.69e-18

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 79.73  E-value: 3.69e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409  462 VSITCKASQD--VITGVAWYQQKPGQSPKLLIY----SASYRYTGVPDRFTGSG--SGTDFTFTISNVQAEDLAVYYCQQ 533
Cdd:smart00406   2 VTLSCKFSGStfSSYYVSWVRQPPGKGLEWLGYigsnGSSYYQESYKGRFTISKdtSKNDVSLTISNLRVEDTGTYYCAV 81
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 449-547 5.15e-17

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 77.50  E-value: 5.15e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 449 QSQKSMSTSVGDRVSITCKAS---QDVITGVAWYQQKPGQSPKLLI--YSASYRYTGVPDRFTGSG--SGTDFTFTISNV 521
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSssmSEASTSVYWYRQPPGKGPTFLIayYSNGSEEGVKKGRFSGRGdpSNGDGSLTIQNL 80

                          90       100
                  ....*....|....*....|....*.
gi 1931703409 522 QAEDLAVYYCQQHYSTPLTFGAGTKL 547
Cdd:pfam07686  81 TLSDSGTYTCAVIPSGEGVFGKGTRL 106
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 573-686 4.54e-10

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 57.85  E-value: 4.54e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 573 QQPGAELVRPGASVKLSCKASGY-SFTTYWMNWVKQRPGQGLEWIGMIHPSDSETrlnQKFKDKATLTVDKSSSTAYMQL 651
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSmSEASTSVYWYRQPPGKGPTFLIAYYSNGSEE---GVKKGRFSGRGDPSNGDGSLTI 77

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1931703409 652 SSPTSEDSAVYYCArstmIATRAMDYWGQGTSVTV 686
Cdd:pfam07686  78 QNLTLSDSGTYTCA----VIPSGEGVFGKGTRLTV 108
ITAM smart00077
Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on ...
 830-850 1.69e-04

Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery.


Pssm-ID: 128390  Cd Length: 21  Bit Score: 39.29  E-value: 1.69e-04
                           10        20
                   ....*....|....*....|.
gi 1931703409  830 NQLYNELNLGRREEYDVLDKR 850
Cdd:smart00077   1 DQLYQPLNKRQRDTYSDLNTR 21
ITAM smart00077
Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on ...
 899-919 7.20e-04

Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery.


Pssm-ID: 128390  Cd Length: 21  Bit Score: 37.36  E-value: 7.20e-04
                           10        20
                   ....*....|....*....|.
gi 1931703409  899 DGLYQGLSTATKDTYDALHMQ 919
Cdd:smart00077   1 DQLYQPLNKRQRDTYSDLNTR 21
ITAM pfam02189
Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex ...
 899-918 2.72e-03

Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex multi-protein cell surface receptor composed of the ligand-sensing TCR heterodimer and three signaling subunits. These signaling subunits contain cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) with a consensus sequence of YxxL/Ix6-12YxxL/I. The two tyrosines are phosphorylated by a Src kinase, Lck or Fyn. Binding of the dually phosphorylated ITAM peptide reorients the two SH2 domains relative to each other, destabilizing inhibitory interactions made by the linker connecting the SH2 and kinase domains.


Pssm-ID: 426646  Cd Length: 20  Bit Score: 35.82  E-value: 2.72e-03
                          10        20
                  ....*....|....*....|
gi 1931703409 899 DGLYQGLSTATKDTYDALHM 918
Cdd:pfam02189   1 DQLYQPLNKRDDDTYSHLGM 20
ITAM pfam02189
Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex ...
 830-849 3.16e-03

Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex multi-protein cell surface receptor composed of the ligand-sensing TCR heterodimer and three signaling subunits. These signaling subunits contain cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) with a consensus sequence of YxxL/Ix6-12YxxL/I. The two tyrosines are phosphorylated by a Src kinase, Lck or Fyn. Binding of the dually phosphorylated ITAM peptide reorients the two SH2 domains relative to each other, destabilizing inhibitory interactions made by the linker connecting the SH2 and kinase domains.


Pssm-ID: 426646  Cd Length: 20  Bit Score: 35.82  E-value: 3.16e-03
                          10        20
                  ....*....|....*....|
gi 1931703409 830 NQLYNELNLGRREEYDVLDK 849
Cdd:pfam02189   1 DQLYQPLNKRDDDTYSHLGM 20
 
Name Accession Description Interval E-value
CASc cd00032
Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent ...
 136-398 1.20e-103

Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide backbone adjacent to an aspartate. The resulting two subunits associate to form an (alpha)2(beta)2-tetramer which is the active enzyme. Activation of caspases can be mediated by other caspase homologs.


Pssm-ID: 237997  Cd Length: 243  Bit Score: 321.86  E-value: 1.20e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 136 AYILSMEPCGHCLIINNVNFCResGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCV 215
Cdd:cd00032     1 IYKMNSKRRGLALIINNENFDK--GLKDRDGTDVDAENLTKLFESLGYEVEVKNNLTAEEILEELKEFASPDHSDSDSFV 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 216 VVILSHGCQashlqfpGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSN 295
Cdd:cd00032    79 CVILSHGEE-------GGIYGTDGDVVPIDEITSLFNGDNCPSLAGKPKLFFIQACRGDELDLGVEVDSGADEPPDVETE 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 296 PEPdatpfqeglrtfdqlDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAV 375
Cdd:cd00032   152 AED---------------DAVQTIPVEADFLVAYSTVPGYVSWRNTKKGSWFIQSLCQVLRKYAHSLDLLDILTKVNRKV 216

                         250       260
                  ....*....|....*....|....*..
gi 1931703409 376 SVK----GIYKQMPGCFNFLRKKLFFK 398
Cdd:cd00032   217 AEKfesvNGKKQMPCFRSTLTKKLYFF 243
CASc smart00115
Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine aspartases that ...
 137-397 7.50e-98

Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine aspartases that mediate programmed cell death (apoptosis). Caspases are synthesised as zymogens and activated by proteolysis of the peptide backbone adjacent to an aspartate. The resulting two subunits associate to form an (alpha)2(beta)2-tetramer which is the active enzyme. Activation of caspases can be mediated by other caspase homologues.


Pssm-ID: 214521  Cd Length: 241  Bit Score: 306.47  E-value: 7.50e-98
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409  137 YILSMEPCGHCLIINNVNFCResgLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQ-QDHGALDCCV 215
Cdd:smart00115   1 YKMNSKPRGLALIINNENFHS---LPRRNGTDVDAENLTELFQSLGYEVQVKNNLTAEEMLEELKEFAAmPEHSDSDSFV 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409  216 VVILSHGcqashlqFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGsn 295
Cdd:smart00115  78 CVLLSHG-------EEGGIYGTDGDPLPLDEIFSLFNGDNCPSLAGKPKLFFIQACRGDELDGGVPVEDSVADPESEG-- 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409  296 pepdatpfqeglrtfdQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAV 375
Cdd:smart00115 149 ----------------EDDAIYKIPVEADFLAAYSTTPGYVSWRNPTRGSWFIQSLCQVLKEYARSLDLLDILTEVNRKV 212

                          250       260
                   ....*....|....*....|....*..
gi 1931703409  376 SVKGIY----KQMPGCFNF-LRKKLFF 397
Cdd:smart00115 213 ADKFESvnakKQMPTIESMtLTKKLYF 239
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
 571-687 1.79e-64

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 212.17  E-value: 1.79e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 571 QLQQPGAELVRPGASVKLSCKASGYSFTTYWMNWVKQRPGQGLEWIGMIHPSDSETRLNQKFKDKATLTVDKSSSTAYMQ 650
Cdd:cd04981     1 QLQESGPGLVKPGQSLKLSCKASGFTFTSYGMGWVRQAPGKGLEWIGLIYPGGGDTYYADSFKGRFTITRDTSKSTAYLQ 80

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1931703409 651 LSSPTSEDSAVYYCARSTMIAT-RAMDYWGQGTSVTVS 687
Cdd:cd04981    81 LNSLTSEDTAVYYCARGLGGYGySYFDYWGQGTTVTVS 118
Peptidase_C14 pfam00656
Caspase domain;
145-396 5.63e-63

Caspase domain;


Pssm-ID: 425803  Cd Length: 213  Bit Score: 211.80  E-value: 5.63e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 145 GHCLIINNVNFCRESglRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQ-QDHGALDCCVVVIL---S 220
Cdd:pfam00656   2 GLALIIGNNNYPGTK--APLRGCDNDAEALAKTLKSLGFEVRVFEDLTAEEIRRALRDFAArADHSDGDSFVVVLLyysG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 221 HGCQashlQFPGAVYGTDGCPVSVEKIVNIFNGTSC-PSLGGKPKLFFIQACGGEQKDHGfevastspedespgsnpepd 299
Cdd:pfam00656  80 HGEQ----VPGGDIYGTDEYLVPVDALTNLFTGDDClPSLVGKPKLFIIDACRGNLEDGG-------------------- 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 300 atpfqeglrtfdqldaisslPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKG 379
Cdd:pfam00656 136 --------------------VVEADFLVAYSTAPGQVSWRNTGSGSWFIQALCQVLREYGHGLDLLSLLTKVRRRVAEAT 195

                         250
                  ....*....|....*...
gi 1931703409 380 IYKQMPGCF-NFLRKKLF 396
Cdd:pfam00656 196 GKKQMPCLSsSTLTKKFY 213
IgV_L_kappa cd04980
Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are ...
 445-549 2.77e-60

Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, kappa type, variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.


Pssm-ID: 409369  Cd Length: 106  Bit Score: 200.31  E-value: 2.77e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 445 IVMTQSQKSMSTSVGDRVSITCKASQDVI-TGVAWYQQKPGQSPKLLIYSASYRYTGVPDRFTGSGSGTDFTFTISNVQA 523
Cdd:cd04980     1 IVMTQSPASLSVSPGERVTISCKASQSISsNYLAWYQQKPGQAPKLLIYYASTLHSGVPSRFSGSGSGTDFTLTISSVEP 80

                          90       100
                  ....*....|....*....|....*.
gi 1931703409 524 EDLAVYYCQQHYSTPLTFGAGTKLEL 549
Cdd:cd04980    81 EDAAVYYCQQGYTFPYTFGGGTKLEI 106
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 5-108 5.05e-43

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 151.49  E-value: 5.05e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409   5 VQVETISPGDGRTfPKRGQTCVVHYTGMLEDGKKVDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYA 84
Cdd:COG0545     1 LQYKVLKEGTGAK-PKAGDTVTVHYTGTLLDGTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELA 79

                          90       100
                  ....*....|....*....|....
gi 1931703409  85 YGATGHPGIIPPHATLVFDVELLK 108
Cdd:COG0545    80 YGERGAGGVIPPNSTLVFEVELLD 103
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
15-107 6.51e-42

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 148.11  E-value: 6.51e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409  15 GRTFPKRGQTCVVHYTGMLEDGKKVDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGH-PGI 93
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLaGPV 80

                          90
                  ....*....|....
gi 1931703409  94 IPPHATLVFDVELL 107
Cdd:pfam00254  81 IPPNATLVFEVELL 94
IgV_L_lambda cd04984
Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of ...
 446-547 2.36e-34

Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, lambda type, variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409373  Cd Length: 105  Bit Score: 126.81  E-value: 2.36e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 446 VMTQSQkSMSTSVGDRVSITCKASQDVITG--VAWYQQKPGQSPKLLIYSASYRYTGVPDRFTGSGSGTDFTFTISNVQA 523
Cdd:cd04984     1 VLTQPS-SLSVSPGETVTITCTGSSGNISGnyVNWYQQKPGSAPRYLIYEDKHRPSGIPDRFSGSKSGNTASLTISGAQT 79

                          90       100
                  ....*....|....*....|....
gi 1931703409 524 EDLAVYYCQQHYSTPLTFGAGTKL 547
Cdd:cd04984    80 EDEADYYCQVWDSNSYVFGGGTKL 103
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 447-548 1.19e-31

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 119.36  E-value: 1.19e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 447 MTQSQKSMSTSVGDRVSITCKASQDVIT-GVAWYQQKPGQSPKLLIYSASYRYT---GVPDRFTGSGSG-TDFTFTISNV 521
Cdd:cd00099     1 VTQSPRSLSVQEGESVTLSCEVSSSFSStYIYWYRQKPGQGPEFLIYLSSSKGKtkgGVPGRFSGSRDGtSSFSLTISNL 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 1931703409 522 QAEDLAVYYCQQHYS---TPLTFGAGTKLE 548
Cdd:cd00099    81 QPEDSGTYYCAVSESggtDKLTFGSGTRLT 110
IGv smart00406
Immunoglobulin V-Type;
585-666 2.31e-27

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 105.93  E-value: 2.31e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409  585 SVKLSCKASGYSFTTYWMNWVKQRPGQGLEWIGMIhPSDSETRLNQKFKDKATLTVDKSSSTAYMQLSSPTSEDSAVYYC 664
Cdd:smart00406   1 SVTLSCKFSGSTFSSYYVSWVRQPPGKGLEWLGYI-GSNGSSYYQESYKGRFTISKDTSKNDVSLTISNLRVEDTGTYYC 79


                   ..
gi 1931703409  665 AR 666
Cdd:smart00406  80 AV 81
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 6-110 5.50e-24

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 102.53  E-value: 5.50e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409   6 QVEtiSPGDGRTfPKRGQTCVVHYTGMLEDGKKVDSSRDRNKPFKFMLgkQEVIRGWEEGVAQMSVGQRAKLTISPDYAY 85
Cdd:PRK10902  151 KVE--KEGTGEA-PKDSDTVVVNYKGTLIDGKEFDNSYTRGEPLSFRL--DGVIPGWTEGLKNIKKGGKIKLVIPPELAY 225

                          90       100
                  ....*....|....*....|....*
gi 1931703409  86 GATGHPGiIPPHATLVFDVELLKLE 110
Cdd:PRK10902  226 GKAGVPG-IPANSTLVFDVELLDVK 249
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 573-686 1.40e-23

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 96.25  E-value: 1.40e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 573 QQPGAELVRPGASVKLSCKASGySFTTYWMNWVKQRPGQGLEWIgmIHPSDSETRLNQKFKDKATLTVDKSSStAYMQLS 652
Cdd:cd00099     3 QSPRSLSVQEGESVTLSCEVSS-SFSSTYIYWYRQKPGQGPEFL--IYLSSSKGKTKGGVPGRFSGSRDGTSS-FSLTIS 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1931703409 653 SPTSEDSAVYYCARSTMIATRaMDYWGQGTSVTV 686
Cdd:cd00099    79 NLQPEDSGTYYCAVSESGGTD-KLTFGSGTRLTV 111
PRK11570 PRK11570
peptidyl-prolyl cis-trans isomerase; Provisional
 4-109 1.31e-19

peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 183207 [Multi-domain]  Cd Length: 206  Bit Score: 87.93  E-value: 1.31e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409   4 GVQVETISPGDGrTFPKRGQTCVVHYTGMLEDGKKVDSSRDRNKPFKFMLGKqeVIRGWEEGVAQMSVGQRAKLTISPDY 83
Cdd:PRK11570  103 GLQFRVLTQGEG-AIPARTDRVRVHYTGKLIDGTVFDSSVARGEPAEFPVNG--VIPGWIEALTLMPVGSKWELTIPHEL 179

                          90       100
                  ....*....|....*....|....*.
gi 1931703409  84 AYGATGHPGIIPPHATLVFDVELLKL 109
Cdd:PRK11570  180 AYGERGAGASIPPFSTLVFEVELLEI 205
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 448-547 3.86e-19

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 83.47  E-value: 3.86e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 448 TQSQKSMSTSVGDRVSITCKASQDVITGVAWYQQKPGQSPKLLIYSASYRYTGVPDRFTGS--GSGTDFTFTISNVQAED 525
Cdd:cd04983     2 TQSPQSLSVQEGENVTLNCNYSTSTFYYLFWYRQYPGQGPQFLIYISSDSGNKKKGRFSATldKSRKSSSLHISAAQLSD 81

                          90       100
                  ....*....|....*....|....*
gi 1931703409 526 LAVYYC---QQHYSTPLTFGAGTKL 547
Cdd:cd04983    82 SAVYFCalsESGGTGKLTFGKGTRL 106
IGv smart00406
Immunoglobulin V-Type;
462-533 3.69e-18

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 79.73  E-value: 3.69e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409  462 VSITCKASQD--VITGVAWYQQKPGQSPKLLIY----SASYRYTGVPDRFTGSG--SGTDFTFTISNVQAEDLAVYYCQQ 533
Cdd:smart00406   2 VTLSCKFSGStfSSYYVSWVRQPPGKGLEWLGYigsnGSSYYQESYKGRFTISKdtSKNDVSLTISNLRVEDTGTYYCAV 81
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
 448-547 1.38e-17

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 79.25  E-value: 1.38e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 448 TQSQKSMSTSVGDRVSITCKASQDViTGVAWYQQKPGQSPKLLIYSAS---YRYTGVP-DRFTGSG-SGTDFTFTISNVQ 522
Cdd:cd05899     2 TQSPRYLIKRRGQSVTLRCSQKSGH-DNMYWYRQDPGKGLQLLFYSYGgglNEEGDLPgDRFSASRpSLTRSSLTIKSAE 80

                          90       100
                  ....*....|....*....|....*...
gi 1931703409 523 AEDLAVYYC---QQHYSTPLTFGAGTKL 547
Cdd:cd05899    81 PEDSAVYLCassLGGGADEAYFGPGTRL 108
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 449-547 5.15e-17

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 77.50  E-value: 5.15e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 449 QSQKSMSTSVGDRVSITCKAS---QDVITGVAWYQQKPGQSPKLLI--YSASYRYTGVPDRFTGSG--SGTDFTFTISNV 521
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSssmSEASTSVYWYRQPPGKGPTFLIayYSNGSEEGVKKGRFSGRGdpSNGDGSLTIQNL 80

                          90       100
                  ....*....|....*....|....*.
gi 1931703409 522 QAEDLAVYYCQQHYSTPLTFGAGTKL 547
Cdd:pfam07686  81 TLSDSGTYTCAVIPSGEGVFGKGTRL 106
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 451-548 1.49e-15

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 72.54  E-value: 1.49e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409  451 QKSMSTSVGDRVSITCKASQDVITGVAWYQQKPgqspKLLIYsasyrytgvPDRFTGSGSGTDFTFTISNVQAEDLAVYY 530
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEVTWYKQGG----KLLAE---------SGRFSVSRSGSTSTLTISNVTPEDSGTYT 67

                           90
                   ....*....|....*...
gi 1931703409  531 CQQHYSTPLTFGaGTKLE 548
Cdd:smart00410  68 CAATNSSGSASS-GTTLT 84
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 447-547 3.41e-15

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 72.40  E-value: 3.41e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 447 MTQSQKSMSTSVGDRVSITCKASQDVI--TGVAWYQQKPGQSPKLLIYSASyrytGVPDRFTGSGSGTDF---------- 514
Cdd:cd04982     1 LEQPQLSITREESKSVTISCKVSGIDFstTYIHWYRQKPGQALERLLYVSS----TSAVRKDSGKTKNKFearkdvgkst 76

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1931703409 515 -TFTISNVQAEDLAVYYC-----QQHYSTPLtFGAGTKL 547
Cdd:cd04982    77 sTLTITNLEKEDSATYYCaywesGSGYYIKV-FGSGTKL 114
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 573-686 5.72e-14

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 68.84  E-value: 5.72e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 573 QQPGAELVRPGASVKLSCkasgySFTTYWMN---WVKQRPGQGLEWIgmIHPSDSETRlnqKFKDKATLTVDKSSSTAYM 649
Cdd:cd04983     3 QSPQSLSVQEGENVTLNC-----NYSTSTFYylfWYRQYPGQGPQFL--IYISSDSGN---KKKGRFSATLDKSRKSSSL 72

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1931703409 650 QLSSPTSEDSAVYYCARSTMIATRAMdYWGQGTSVTV 686
Cdd:cd04983    73 HISAAQLSDSAVYFCALSESGGTGKL-TFGKGTRLTV 108
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
 573-686 2.65e-13

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 66.92  E-value: 2.65e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 573 QQPGAELVRPGASVKLSC-KASGYsfttYWMNWVKQRPGQGLEWIGmihpsdseTRLNQKFKDKATLTVDK------SSS 645
Cdd:cd05899     3 QSPRYLIKRRGQSVTLRCsQKSGH----DNMYWYRQDPGKGLQLLF--------YSYGGGLNEEGDLPGDRfsasrpSLT 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1931703409 646 TAYMQLSSPTSEDSAVYYCARStmiATRAMD--YWGQGTSVTV 686
Cdd:cd05899    71 RSSLTIKSAEPEDSAVYLCASS---LGGGADeaYFGPGTRLTV 110
SlpA COG1047
Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein ...
 20-106 1.78e-12

Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440668 [Multi-domain]  Cd Length: 138  Bit Score: 65.51  E-value: 1.78e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409  20 KRGQTCVVHYTGMLEDGKKVDSSRDRnKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGatghpgiiPPHAT 99
Cdd:COG1047     2 EKGDVVTLHYTLKLEDGEVFDSTFEG-EPLEFLHGAGQLIPGLEEALEGMEVGDKKTVTLPPEEAYG--------ERDPE 72


                  ....*..
gi 1931703409 100 LVFDVEL 106
Cdd:COG1047    73 LVQTVPR 79
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 575-686 7.45e-12

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 62.14  E-value: 7.45e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409  575 PGAELVRPGASVKLSCKASGYSftTYWMNWVKQrpgqGLEWIGmihpsdsetrlnqkfkDKATLTVDKSSSTAYMQLSSP 654
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSP--PPEVTWYKQ----GGKLLA----------------ESGRFSVSRSGSTSTLTISNV 58

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1931703409  655 TSEDSAVYYCARStmiaTRAMDYWGqGTSVTV 686
Cdd:smart00410  59 TPEDSGTYTCAAT----NSSGSASS-GTTLTV 85
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 572-666 8.87e-12

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 62.77  E-value: 8.87e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 572 LQQPGAELVRP-GASVKLSCKASGYSFTTYWMNWVKQRPGQGLEWIGMIHPSDSETRLNQKFKDKATLTVDKSSSTAYMQ 650
Cdd:cd04982     1 LEQPQLSITREeSKSVTISCKVSGIDFSTTYIHWYRQKPGQALERLLYVSSTSAVRKDSGKTKNKFEARKDVGKSTSTLT 80

                          90
                  ....*....|....*.
gi 1931703409 651 LSSPTSEDSAVYYCAR 666
Cdd:cd04982    81 ITNLEKEDSATYYCAY 96
IgV_L_lambda cd04984
Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of ...
 572-686 1.33e-11

Immunoglobulin (Ig) lambda light chain variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, lambda type, variable (V) domain. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409373  Cd Length: 105  Bit Score: 62.09  E-value: 1.33e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 572 LQQPGAELVRPGASVKLSCKASGYSFTTYWMNWVKQRPGQGLEW-IGMIH--PSDSETRLNQKfkdkatltvdKSSSTAY 648
Cdd:cd04984     2 LTQPSSLSVSPGETVTITCTGSSGNISGNYVNWYQQKPGSAPRYlIYEDKhrPSGIPDRFSGS----------KSGNTAS 71

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1931703409 649 MQLSSPTSEDSAVYYCARStmiatRAMDY-WGQGTSVTV 686
Cdd:cd04984    72 LTISGAQTEDEADYYCQVW-----DSNSYvFGGGTKLTV 105
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 573-686 4.54e-10

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 57.85  E-value: 4.54e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 573 QQPGAELVRPGASVKLSCKASGY-SFTTYWMNWVKQRPGQGLEWIGMIHPSDSETrlnQKFKDKATLTVDKSSSTAYMQL 651
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSmSEASTSVYWYRQPPGKGPTFLIAYYSNGSEE---GVKKGRFSGRGDPSNGDGSLTI 77

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1931703409 652 SSPTSEDSAVYYCArstmIATRAMDYWGQGTSVTV 686
Cdd:pfam07686  78 QNLTLSDSGTYTCA----VIPSGEGVFGKGTRLTV 108
IgV_TCR_delta cd07706
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here ...
 448-547 1.98e-09

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the delta chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409503  Cd Length: 112  Bit Score: 55.99  E-value: 1.98e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 448 TQSQKSMSTSVGDRVSITCK-ASQDVITGVAWYQQKPGQSPKLLIYSASYRYTGVPDRFTGSGSGTD--FTFTISNVQAE 524
Cdd:cd07706     3 TQAQPDVSVQVGEEVTLNCRyETSWTNYYLFWYKQLPSGEMTFLIRQDSSEQNAKSGRYSVNFQKAQksISLTISALQLE 82

                          90       100
                  ....*....|....*....|....*.
gi 1931703409 525 DLAVYYCQQHYSTP---LTFGAGTKL 547
Cdd:cd07706    83 DSAKYFCALSLPYDtdkLIFGKGTRL 108
IgV_TCR_gammadelta cd20988
Gammadelta T-cell antigen receptor, variable (V) domain; The members here are composed of the ...
 580-686 1.07e-07

Gammadelta T-cell antigen receptor, variable (V) domain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409580  Cd Length: 114  Bit Score: 51.02  E-value: 1.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 580 VRPGASVKLSCKASGYSFTTYWMNWVKQRPGQGLEWI----GMIHPSdsetrlnqkFKDKATLTVDKSSSTAYMQLSSPT 655
Cdd:cd20988    10 VSVGKPVTLKCSMKGEAISNYYINWYRKTQGNTMTFIyregGIYGPG---------FKDNFRGDIDSSNNLAVLKILEAS 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1931703409 656 SEDSAVYYCARSTMIATRAMD--YWGQGTSVTV 686
Cdd:cd20988    81 ERDEGSYYCASDTPGGGREYDplIFGKGTYLTV 113
IgV_H_TCR_mu cd16095
T-cell receptor Mu, Heavy chain, variable (V) domain; The members here are composed of the ...
 569-686 1.29e-07

T-cell receptor Mu, Heavy chain, variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain of the T-cell receptor Mu. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409514  Cd Length: 115  Bit Score: 51.02  E-value: 1.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 569 QVQLQQPGAELVRPGASVKLSCKASGYSFTTYWMNWVKQRPGQGLEWIGMIHPSDSETRlnqkfKDKATLTVDKSSSTAY 648
Cdd:cd16095     1 ETQLEESGGGSHPAGKTLSLKCQTSGFQFNTSQLSWYLWVPGHAPLWLTSLDHISTKVS-----EDRITSSREDTNSQIF 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1931703409 649 MQLSSPTSEDSAVYYCARsTMIATRAMD--YWGQGTSVTV 686
Cdd:cd16095    76 LQIKGLGLRDSGQYHCAR-RVGYGDDTDklIFGPGTDVIV 114
IgV_CD8_beta cd07700
Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The ...
 572-686 1.32e-07

Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The members here are composed of the immunoglobulin (Ig)-like domain in Cluster of Differentiation (CD) 8 beta. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409497  Cd Length: 116  Bit Score: 50.91  E-value: 1.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 572 LQQPGAELVRPGASVKLSCKASGYSFTT--YWMNWvKQRPG--QGLEWIGMIHPSDSETRLNQKFKDKATLTVDKSSSTA 647
Cdd:cd07700     2 LQTPGSLLVQTNQTVKMSCEAKTSPKNTriYWLRQ-RQAPSkdSHFEFLASWDPSKGIVYGEGVDQEKLIILSDSDSSRY 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1931703409 648 YMQLSSPTSEDSAVYYCArstMIATRAMDYwGQGTSVTV 686
Cdd:cd07700    81 ILSLMSVKPEDSGTYFCM---TVGSPELIF-GTGTKLSV 115
IgV_H cd04981
Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the ...
 459-535 1.59e-07

Immunoglobulin (Ig) heavy chain (H), variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains.


Pssm-ID: 409370 [Multi-domain]  Cd Length: 118  Bit Score: 50.77  E-value: 1.59e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 459 GDRVSITCKASQDVIT--GVAWYQQKPGQSPKLL--IY---SASYRYTGVPDRFTGS--GSGTDFTFTISNVQAEDLAVY 529
Cdd:cd04981    13 GQSLKLSCKASGFTFTsyGMGWVRQAPGKGLEWIglIYpggGDTYYADSFKGRFTITrdTSKSTAYLQLNSLTSEDTAVY 92


                  ....*.
gi 1931703409 530 YCQQHY 535
Cdd:cd04981    93 YCARGL 98
IgV_CD8_alpha cd05720
Immunoglobulin (Ig)-like variable (V) domain of Cluster of Differentiation (CD) 8 alpha chain; ...
 450-531 2.63e-07

Immunoglobulin (Ig)-like variable (V) domain of Cluster of Differentiation (CD) 8 alpha chain; The members here are composed of the immunoglobulin (Ig)-like variable domain of the Cluster of Differentiation (CD) 8 alpha. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. The Ig domain of CD8 alpha binds to antibodies. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409385  Cd Length: 110  Bit Score: 49.79  E-value: 2.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 450 SQKSMSTSVGDRVSITCKASQDVITGVAWYQQKPGQSPKL--LIYSASYRYTGVPD-----RFTGSGSGTDFTFTISNVQ 522
Cdd:cd05720     4 SPRKRDAQLGQKVELVCEVLNSVPQGCSWLFQPRGSAPQPtfLLYLSSSNKTKWAEgldskRFSGSRSGSSYVLTLKDFR 83


                  ....*....
gi 1931703409 523 AEDLAVYYC 531
Cdd:cd05720    84 KEDEGYYFC 92
IgV_L_kappa cd04980
Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are ...
 573-664 7.51e-07

Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, kappa type, variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.


Pssm-ID: 409369  Cd Length: 106  Bit Score: 48.54  E-value: 7.51e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 573 QQPGAELVRPGASVKLSCKASGySFTTYWMNWVKQRPGQglewigmihpsdSETRLNQKFKDKATLTVDKSSSTAY---- 648
Cdd:cd04980     5 QSPASLSVSPGERVTISCKASQ-SISSNYLAWYQQKPGQ------------APKLLIYYASTLHSGVPSRFSGSGSgtdf 71

                          90
                  ....*....|....*..
gi 1931703409 649 -MQLSSPTSEDSAVYYC 664
Cdd:cd04980    72 tLTISSVEPEDAAVYYC 88
PRK15095 PRK15095
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 27-86 1.58e-06

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 237908 [Multi-domain]  Cd Length: 156  Bit Score: 48.94  E-value: 1.58e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409  27 VHYTGMLEDGKKVDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYG 86
Cdd:PRK15095   13 VHFTLKLDDGSTAESTRNNGKPALFRLGDGSLSEGLEQQLLGLKVGDKKTFSLEPEAAFG 72
IgV_SIRP cd16097
Immunoglobulin (Ig)-like variable (V) domain of the Signal-Regulatory Protein (SIRP); The ...
 447-550 2.94e-06

Immunoglobulin (Ig)-like variable (V) domain of the Signal-Regulatory Protein (SIRP); The members here are composed of the immunoglobulin (Ig)-like domain of the Signal-Regulatory Protein (SIRP). The SIRPs belong to the "paired receptors" class of membrane proteins that comprise several genes coding for proteins with similar extracellular regions, but very different transmembrane/cytoplasmic regions with different (activating or inhibitory) signaling potentials. They are commonly on NK cells, but are also on many myeloid cells. Their extracellular region contains three immunoglobulin superfamily domains, a single V-set, and two C1-set IgSF domains. Their cytoplasmic tails that contain either ITIMs or transmembrane regions have positively charged residues that allow an association with adaptor proteins, such as DAP12/KARAP, containing ITAMs. There are 3 distinct SIRP members: alpha, beta, and gamma. SIRP alpha (also known as CD172a or SRC homology 2 domain-containing protein tyrosine phosphatase substrate 1/Shps-1) is a membrane receptor that interacts with a ligand CD47 expressed on many cells and gives an inhibitory signal through immunoreceptor tyrosine-based inhibition motifs in the cytoplasmic region that interact with phosphatases SHP-1 and SHP-2. SIRP beta has a short cytoplasmic region and associates with a transmembrane adapter protein DAP12 containing immunoreceptor tyrosine-based activation motifs to give an activating signal. SIRP gamma contains a very short cytoplasmic region lacking obvious signaling motifs, but also binds CD47 with much less affinity. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409516  Cd Length: 111  Bit Score: 46.78  E-value: 2.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 447 MTQSQKSMSTSVGDRVSITCKASQDVITG-VAWYQqkpGQSP-KLLIYSASY----RYTGVPDrfTGSGSGTDFTFTISN 520
Cdd:cd16097     2 VIQPEKSVSVAAGESATLHCTVTSLIPVGpIQWFR---GAGPgRELIYNQKEghfpRVTTVSD--LTKRNNMDFSIRISN 76

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1931703409 521 VQAEDLAVYYCQQH-----YSTPLTFGAGTKLELK 550
Cdd:cd16097    77 ITPADAGTYYCVKFrkgspDDVEFKSGAGTELSVR 111
IgV_TCR_delta cd07706
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here ...
 583-686 3.40e-06

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the delta chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409503  Cd Length: 112  Bit Score: 46.74  E-value: 3.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 583 GASVKLSCKASgYSFTTYWMNWVKQRPGQglEWIGMIHPSDSETrlNQKfKDKATLTVDKSSSTAYMQLSSPTSEDSAVY 662
Cdd:cd07706    14 GEEVTLNCRYE-TSWTNYYLFWYKQLPSG--EMTFLIRQDSSEQ--NAK-SGRYSVNFQKAQKSISLTISALQLEDSAKY 87

                          90       100
                  ....*....|....*....|....
gi 1931703409 663 YCARSTMIATRAMDYwGQGTSVTV 686
Cdd:cd07706    88 FCALSLPYDTDKLIF-GKGTRLTV 110
IgV_CD8_beta cd07700
Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The ...
 449-547 5.40e-05

Immunoglobulin (Ig) variable (V) domain of Cluster of Differentiation (CD) 8 beta chain; The members here are composed of the immunoglobulin (Ig)-like domain in Cluster of Differentiation (CD) 8 beta. The CD8 glycoprotein plays an essential role in the control of T-cell selection, maturation, and the T-cell receptor (TCR)-mediated response to peptide antigen. CD8 is comprised of alpha and beta subunits and is expressed as either an alpha/alpha or alpha/beta dimer. Both dimeric isoforms can serve as a coreceptor for T cell activation and differentiation, however they have distinct physiological roles, different cellular distributions, unique binding partners, etc. Each CD8 subunit is comprised of an extracellular domain containing a V-type Ig-like domain, a single pass transmembrane portion, and a short intracellular domain. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409497  Cd Length: 116  Bit Score: 43.59  E-value: 5.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 449 QSQKSMSTSVGDRVSITCKA-SQDVITGVAWYQQKPGQSP----KLLIYSASYR---Y-TGV-PDRFT--GSGSGTDFTF 516
Cdd:cd07700     3 QTPGSLLVQTNQTVKMSCEAkTSPKNTRIYWLRQRQAPSKdshfEFLASWDPSKgivYgEGVdQEKLIilSDSDSSRYIL 82

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1931703409 517 TISNVQAEDLAVYYCQQHYSTPLTFGAGTKL 547
Cdd:cd07700    83 SLMSVKPEDSGTYFCMTVGSPELIFGTGTKL 113
IgV_CD79b_beta cd16096
Immunoglobulin variable domain (IgV) Cluster of Differentiation (CD) 79B; The members here are ...
 476-547 1.03e-04

Immunoglobulin variable domain (IgV) Cluster of Differentiation (CD) 79B; The members here are composed of the immunoglobulin variable domain (IgV) of the Cluster of Differentiation (CD) 79B (also known as CD79b molecule, immunoglobulin-associated beta (Ig-beta), and B29). The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. Members of the IgV family are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409515  Cd Length: 96  Bit Score: 42.25  E-value: 1.03e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1931703409 476 VAWYQQKPGQSPKLLIYSASyrytgvpdRFTGSGSGTDFTFTISNVQAEDLAVYYCQQ---HYSTPLTFGAGTKL 547
Cdd:cd16096    28 MTWFRKKGNQRPQELFPEDG--------RISQTQNGSVYTLTIQNIQYEDNGIYFCQQkcnSTEPDVTDGCGTEL 94
ITAM smart00077
Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on ...
 830-850 1.69e-04

Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery.


Pssm-ID: 128390  Cd Length: 21  Bit Score: 39.29  E-value: 1.69e-04
                           10        20
                   ....*....|....*....|.
gi 1931703409  830 NQLYNELNLGRREEYDVLDKR 850
Cdd:smart00077   1 DQLYQPLNKRQRDTYSDLNTR 21
I-set pfam07679
Immunoglobulin I-set domain;
446-532 3.20e-04

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 40.32  E-value: 3.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 446 VMTQSQKSMSTSVGDRVSITCKasqdvITG-----VAWYqqKPGQSpklLIYSASYRYTGVPDRFTgsgsgtdftFTISN 520
Cdd:pfam07679   2 KFTQKPKDVEVQEGESARFTCT-----VTGtpdpeVSWF--KDGQP---LRSSDRFKVTYEGGTYT---------LTISN 62

                          90
                  ....*....|..
gi 1931703409 521 VQAEDLAVYYCQ 532
Cdd:pfam07679  63 VQPDDSGKYTCV 74
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 446-532 3.24e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 40.24  E-value: 3.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 446 VMTQSQKSMSTSVGDRVSITCKASQDVITGVAWYqqKPGQspklLIYSASYRYTGVpdrftgsgSGTDFTFTISNVQAED 525
Cdd:pfam13927   3 VITVSPSSVTVREGETVTLTCEATGSPPPTITWY--KNGE----PISSGSTRSRSL--------SGSNSTLTISNVTRSD 68


                  ....*..
gi 1931703409 526 LAVYYCQ 532
Cdd:pfam13927  69 AGTYTCV 75
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 574-664 4.06e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 39.86  E-value: 4.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1931703409 574 QPGAELVRPGASVKLSCKASGYSFTTYWmnWvkqrpgqglewigmihpsdseTRLNQKFKDKATLTVDKSSSTAYMQLSS 653
Cdd:pfam13927   7 SPSSVTVREGETVTLTCEATGSPPPTIT--W---------------------YKNGEPISSGSTRSRSLSGSNSTLTISN 63

                          90
                  ....*....|.
gi 1931703409 654 PTSEDSAVYYC 664
Cdd:pfam13927  64 VTRSDAGTYTC 74
ITAM smart00077
Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on ...
 899-919 7.20e-04

Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery.


Pssm-ID: 128390  Cd Length: 21  Bit Score: 37.36  E-value: 7.20e-04
                           10        20
                   ....*....|....*....|.
gi 1931703409  899 DGLYQGLSTATKDTYDALHMQ 919
Cdd:smart00077   1 DQLYQPLNKRQRDTYSDLNTR 21
ITAM pfam02189
Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex ...
 899-918 2.72e-03

Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex multi-protein cell surface receptor composed of the ligand-sensing TCR heterodimer and three signaling subunits. These signaling subunits contain cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) with a consensus sequence of YxxL/Ix6-12YxxL/I. The two tyrosines are phosphorylated by a Src kinase, Lck or Fyn. Binding of the dually phosphorylated ITAM peptide reorients the two SH2 domains relative to each other, destabilizing inhibitory interactions made by the linker connecting the SH2 and kinase domains.


Pssm-ID: 426646  Cd Length: 20  Bit Score: 35.82  E-value: 2.72e-03
                          10        20
                  ....*....|....*....|
gi 1931703409 899 DGLYQGLSTATKDTYDALHM 918
Cdd:pfam02189   1 DQLYQPLNKRDDDTYSHLGM 20
ITAM pfam02189
Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex ...
 830-849 3.16e-03

Immunoreceptor tyrosine-based activation motif; T cell receptor (TCR) is a complex multi-protein cell surface receptor composed of the ligand-sensing TCR heterodimer and three signaling subunits. These signaling subunits contain cytoplasmic immunoreceptor tyrosine-based activation motifs (ITAMs) with a consensus sequence of YxxL/Ix6-12YxxL/I. The two tyrosines are phosphorylated by a Src kinase, Lck or Fyn. Binding of the dually phosphorylated ITAM peptide reorients the two SH2 domains relative to each other, destabilizing inhibitory interactions made by the linker connecting the SH2 and kinase domains.


Pssm-ID: 426646  Cd Length: 20  Bit Score: 35.82  E-value: 3.16e-03
                          10        20
                  ....*....|....*....|
gi 1931703409 830 NQLYNELNLGRREEYDVLDK 849
Cdd:pfam02189   1 DQLYQPLNKRDDDTYSHLGM 20
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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