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Conserved domains on  [gi|1930395038|ref|XP_037288624|]
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LOW QUALITY PROTEIN: transcription elongation factor SPT5-like [Rhipicephalus microplus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NGN_Euk cd09888
Eukaryotic N-Utilization Substance G (NusG) N-terminal (NGN) domain, including plant KTF1 (KOW ...
 208-295 6.14e-40

Eukaryotic N-Utilization Substance G (NusG) N-terminal (NGN) domain, including plant KTF1 (KOW domain-containing Transcription Factor 1); The N-Utilization Substance G (NusG) protein and its eukaryotic homolog, Spt5, are involved in transcription elongation and termination. NusG contains an NGN domain at its N-terminus and Kyrpides Ouzounis and Woese (KOW) repeats at its C-terminus. Spt5 forms an Spt4-Spt5 complex that is an essential RNA polymerase II elongation factor. NusG was originally discovered as an N-dependent antitermination enhancing activity in Escherichia coli, and has a variety of functions such as its involvement in RNA polymerase elongation and Rho-termination in bacteria. Orthologs of the NusG gene exist in all bacteria, but their functions and requirements are different. Spt5-like is homologous to the Spt5 proteins present in all eukaryotes, which is unique as it encodes a protein with an additional long carboxy-terminal extension that contains WG/GW motifs. Spt5-like, or KTF1 (KOW domain-containing Transcription Factor 1), is a RNA-directed DNA methylation (RdDM) pathway effector in plants.


:

Pssm-ID: 193577 [Multi-domain]  Cd Length: 86  Bit Score: 142.28  E-value: 6.14e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  208 NLWMVKCRIGEEKSTVLQMMRKFIAYQYSEEPLQIRSVVAPEGVKGYVYIEAYKHTHVKQCIQGIGNLRIGlyQQMMVPI 287
Cdd:cd09888      1 KLWAVKCKPGKEREIVISLMRKFLDLQRTGNPLGIKSVFARDGLKGYIYIEARKEAHVKDAIEGLRGVYLN--TIKLVPI 78


                   ....*...
gi 1930395038  288 KEMTDVLR 295
Cdd:cd09888     79 KEMPDVLS 86
KOW_Spt5_3 cd06083
KOW domain of Spt5, repeat 3; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW ...
 501-551 7.29e-28

KOW domain of Spt5, repeat 3; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW motifs at its C-terminus. Spt5 is involved in transcription elongation and termination. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KOW_Spt5 domains play critical roles in recruitment of multiple other eukaryotic transcription elongation and RNA biogenesis factors and additionally are involved in the binding of the eukaryotic Spt5 proteins to RNA polymerases.


:

Pssm-ID: 240507  Cd Length: 51  Bit Score: 106.46  E-value: 7.29e-28
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1930395038  501 YFKMGDHVKVIAGRFEGDTGLIVRVEDNMVVLFSDLTMHELKVLPRDLQLC 551
Cdd:cd06083      1 HFKVGDHVKVISGRHEGETGLVVKVEDDVVTVFSDLTMRELKVFPRDLQLS 51
KOW_Spt5_5 cd06085
KOW domain of Spt5, repeat 5; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW ...
 729-779 1.08e-26

KOW domain of Spt5, repeat 5; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW motifs at its C-terminus. Spt5 is involved in transcription elongation and termination. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KOW_Spt5 domains play critical roles in recruitment of multiple other eukaryotic transcription elongation and RNA biogenesis factors and additionally are involved in the binding of the eukaryotic Spt5 proteins to RNA polymerases.


:

Pssm-ID: 240509  Cd Length: 52  Bit Score: 103.33  E-value: 1.08e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1930395038  729 DSELIGQTIKITQGPYKGHIGIVKDATETTARVELHTKCQTISVDRSRISV 779
Cdd:cd06085      2 RDPLIGKTVRIRKGPYKGYIGIVKDATGTTARVELHSKNKTITVDRSRLAV 52
CTD smart01104
Spt5 C-terminal nonapeptide repeat binding Spt4; The C-terminal domain of the transcription ...
 803-925 1.55e-24

Spt5 C-terminal nonapeptide repeat binding Spt4; The C-terminal domain of the transcription elongation factor protein Spt5 is necessary for binding to Spt4 to form the functional complex that regulates early transcription elongation by RNA polymerase II. The complex may be involved in pre-mRNA processing through its association with mRNA capping enzymes. This CTD domain carries a regular nonapeptide repeat that can be present in up to 18 copies, as in S. pombe. The repeat has a characteristic TPA motif.


:

Pssm-ID: 215026 [Multi-domain]  Cd Length: 121  Bit Score: 99.52  E-value: 1.55e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038   803 GSQTPMY-QSGSRTPMYGSQTPLYEAGSRT--PHFGGGQTPLHDG--SRTPVHGAWDPTASNTPARtELDDYTLDEGSPS 877
Cdd:smart01104    1 GGRTPAWgASGSKTPAWGSRTPGTAAGGAPtaRGGSGSRTPAWGGagSRTPAWGGAGPTGSRTPAW-GGASAWGNKSSEG 79

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*...
gi 1930395038   878 PSYqPATPGYQAPETPQGPYTPQTPGMYGsdhsySPSPTAYQPSPSPT 925
Cdd:smart01104   80 SAS-SWAAGPGGAYGAPTPGYGGTPSAYG-----PATPGGGAMAGSAS 121
KOW_Spt5_2 cd06082
KOW domain of Spt5, repeat 2; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW ...
 450-500 1.56e-22

KOW domain of Spt5, repeat 2; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW motifs at its C-terminus. Spt5 is involved in transcription elongation and termination. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KOW_Spt5 domains play critical roles in recruitment of multiple other eukaryotic transcription elongation and RNA biogenesis factors and additionally are involved in the binding of the eukaryotic Spt5 proteins to RNA polymerases.


:

Pssm-ID: 240506  Cd Length: 51  Bit Score: 91.41  E-value: 1.56e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1930395038  450 FAPGDNVEVAEGELVHLQGKIISIDGNKITMLPKHEDLTDPLDFQAHELKK 500
Cdd:cd06082      1 FQPGDNVEVIEGELKGLQGKVESVDGDIVTIMPKHEDLKEPLEFPAKELRK 51
KOW_Spt5_4 cd06084
KOW domain of Spt5, repeat 4; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW ...
 627-669 3.75e-21

KOW domain of Spt5, repeat 4; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW motifs at its C-terminus. Spt5 is involved in transcription elongation and termination. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KOW_Spt5 domains play critical roles in recruitment of multiple other eukaryotic transcription elongation and RNA biogenesis factors and additionally are involved in the binding of the eukaryotic Spt5 proteins to RNA polymerases.


:

Pssm-ID: 240508  Cd Length: 43  Bit Score: 87.19  E-value: 3.75e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1930395038  627 RDIVKVIDGPHSGRQGDVKHIFRNFAFLHSRMMLENGGIFVCK 669
Cdd:cd06084      1 GDTVKVVDGPYKGRQGTVLHIYRGTLFLHSREVTENGGIFVVR 43
KOW_Spt5_6 cd06086
KOW domain of Spt5, repeat 6; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW ...
 1025-1083 6.59e-21

KOW domain of Spt5, repeat 6; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW motifs at its C-terminus. Spt5 is involved in transcription elongation and termination. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KOW_Spt5 domains play critical roles in recruitment of multiple other eukaryotic transcription elongation and RNA biogenesis factors and additionally are involved in the binding of the eukaryotic Spt5 proteins to RNA polymerases.


:

Pssm-ID: 240510  Cd Length: 58  Bit Score: 86.80  E-value: 6.59e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1930395038 1025 EHLEPVPPTlRGDKVKVLMGEDREETGELLSIDMREGVVKIFSSGKITMQALRYFCKMH 1083
Cdd:cd06086      1 EHLEPVPPE-KGDRVKVIKGEDRGSTGELISIDGADGIVKMDSDGDIKILPMNFLAKLV 58
KOW_Spt5_1 cd06081
KOW domain of Spt5, repeat 1; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW ...
 306-343 2.81e-17

KOW domain of Spt5, repeat 1; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW motifs at its C-terminus. Spt5 is involved in transcription elongation and termination. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KOW_Spt5 domains play critical roles in recruitment of multiple other eukaryotic transcription elongation and RNA biogenesis factors and additionally are involved in the binding of the eukaryotic Spt5 proteins to RNA polymerases.


:

Pssm-ID: 240505  Cd Length: 38  Bit Score: 75.97  E-value: 2.81e-17
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1930395038  306 KQWVRLKRGIYRDDLAQVDYVDTAQGQVNLKLLPRVDY 343
Cdd:cd06081      1 GSWVRIKRGIYKGDLAQVDEVDENGNRVVVKLIPRIDY 38
DUF3432 super family cl25500
Domain of unknown function (DUF3432); This presumed domain is functionally uncharacterized. ...
 910-959 4.84e-06

Domain of unknown function (DUF3432); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 100 amino acids in length. This domain is found associated with pfam00096. This domain has two conserved sequence motifs: YPSPV and PSP.


The actual alignment was detected with superfamily member pfam11914:

Pssm-ID: 403204 [Multi-domain]  Cd Length: 98  Bit Score: 46.25  E-value: 4.84e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1930395038  910 SYSPSPTAYQPSPSPTGYvttPSPVTFQAGTPSPSTYGgySPTTPGAPSP 959
Cdd:pfam11914   14 SYSSSVTTSYPSPITTSY---PSPVSTSYSSPVPSSYP--SPVHTSFPSP 58
Spt5_N pfam11942
Spt5 transcription elongation factor, acidic N-terminal; This is the very acidic N-terminal ...
 128-202 1.44e-04

Spt5 transcription elongation factor, acidic N-terminal; This is the very acidic N-terminal region of the early transcription elongation factor Spt5. The Spt5-Spt4 complex regulates early transcription elongation by RNA polymerase II and has an imputed role in pre-mRNA processing via its physical association with mRNA capping enzymes. The actual function of this N-terminal domain is not known although it is dispensable for binding to Spt4.


:

Pssm-ID: 463406  Cd Length: 97  Bit Score: 41.87  E-value: 1.44e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1930395038  128 DGAEDMIDSHRpaeetsskELNSHRRLQMmltSQKEDEIEDYYRRKYADTTAAEggYREADVElsdEIAQQTLLP 202
Cdd:pfam11942   39 EDGRRDDRRHR--------ELDRRRELEE---DEDAEEIAEYLKERYGRSSSDA--YRGDAEE---GVPQRLLLP 97
 
Name Accession Description Interval E-value
NGN_Euk cd09888
Eukaryotic N-Utilization Substance G (NusG) N-terminal (NGN) domain, including plant KTF1 (KOW ...
 208-295 6.14e-40

Eukaryotic N-Utilization Substance G (NusG) N-terminal (NGN) domain, including plant KTF1 (KOW domain-containing Transcription Factor 1); The N-Utilization Substance G (NusG) protein and its eukaryotic homolog, Spt5, are involved in transcription elongation and termination. NusG contains an NGN domain at its N-terminus and Kyrpides Ouzounis and Woese (KOW) repeats at its C-terminus. Spt5 forms an Spt4-Spt5 complex that is an essential RNA polymerase II elongation factor. NusG was originally discovered as an N-dependent antitermination enhancing activity in Escherichia coli, and has a variety of functions such as its involvement in RNA polymerase elongation and Rho-termination in bacteria. Orthologs of the NusG gene exist in all bacteria, but their functions and requirements are different. Spt5-like is homologous to the Spt5 proteins present in all eukaryotes, which is unique as it encodes a protein with an additional long carboxy-terminal extension that contains WG/GW motifs. Spt5-like, or KTF1 (KOW domain-containing Transcription Factor 1), is a RNA-directed DNA methylation (RdDM) pathway effector in plants.


Pssm-ID: 193577 [Multi-domain]  Cd Length: 86  Bit Score: 142.28  E-value: 6.14e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  208 NLWMVKCRIGEEKSTVLQMMRKFIAYQYSEEPLQIRSVVAPEGVKGYVYIEAYKHTHVKQCIQGIGNLRIGlyQQMMVPI 287
Cdd:cd09888      1 KLWAVKCKPGKEREIVISLMRKFLDLQRTGNPLGIKSVFARDGLKGYIYIEARKEAHVKDAIEGLRGVYLN--TIKLVPI 78


                   ....*...
gi 1930395038  288 KEMTDVLR 295
Cdd:cd09888     79 KEMPDVLS 86
Spt5-NGN pfam03439
Early transcription elongation factor of RNA pol II, NGN section; Spt5p and prokaryotic NusG ...
 208-294 2.54e-28

Early transcription elongation factor of RNA pol II, NGN section; Spt5p and prokaryotic NusG are shown to contain a novel 'NGN' domain. The combined NGN and KOW motif regions of Spt5 form the binding domain with Spt4. Spt5 complexes with Spt4 as a 1:1 heterodimer snf this Spt5-Spt4 complex regulates early transcription elongation by RNA polymerase II and has an imputed role in pre-mRNA processing via its physical association with mRNA capping enzymes. The Schizosaccharomyces pombe core Spt5-Spt4 complex is a heterodimer bearing a trypsin-resistant Spt4-binding domain within the Spt5 subunit.


Pssm-ID: 397481  Cd Length: 84  Bit Score: 109.21  E-value: 2.54e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  208 NLWMVKCRIGEEKSTVLQMMRKFIAYQYSEEpLQIRSVVAPEGVKGYVYIEAYKHTHVKQCIQGIGNLRiGLYQQmMVPI 287
Cdd:pfam03439    1 KIWAVKCTPGQEREVALSLMRKILALAKTNN-LGIYSVFAPDGLKGYIYVEADRQAAVKRALEGIPNVR-GLVPG-LVPI 77


                   ....*..
gi 1930395038  288 KEMTDVL 294
Cdd:pfam03439   78 KEMEHLL 84
KOW_Spt5_3 cd06083
KOW domain of Spt5, repeat 3; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW ...
 501-551 7.29e-28

KOW domain of Spt5, repeat 3; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW motifs at its C-terminus. Spt5 is involved in transcription elongation and termination. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KOW_Spt5 domains play critical roles in recruitment of multiple other eukaryotic transcription elongation and RNA biogenesis factors and additionally are involved in the binding of the eukaryotic Spt5 proteins to RNA polymerases.


Pssm-ID: 240507  Cd Length: 51  Bit Score: 106.46  E-value: 7.29e-28
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1930395038  501 YFKMGDHVKVIAGRFEGDTGLIVRVEDNMVVLFSDLTMHELKVLPRDLQLC 551
Cdd:cd06083      1 HFKVGDHVKVISGRHEGETGLVVKVEDDVVTVFSDLTMRELKVFPRDLQLS 51
KOW_Spt5_5 cd06085
KOW domain of Spt5, repeat 5; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW ...
 729-779 1.08e-26

KOW domain of Spt5, repeat 5; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW motifs at its C-terminus. Spt5 is involved in transcription elongation and termination. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KOW_Spt5 domains play critical roles in recruitment of multiple other eukaryotic transcription elongation and RNA biogenesis factors and additionally are involved in the binding of the eukaryotic Spt5 proteins to RNA polymerases.


Pssm-ID: 240509  Cd Length: 52  Bit Score: 103.33  E-value: 1.08e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1930395038  729 DSELIGQTIKITQGPYKGHIGIVKDATETTARVELHTKCQTISVDRSRISV 779
Cdd:cd06085      2 RDPLIGKTVRIRKGPYKGYIGIVKDATGTTARVELHSKNKTITVDRSRLAV 52
CTD smart01104
Spt5 C-terminal nonapeptide repeat binding Spt4; The C-terminal domain of the transcription ...
 803-925 1.55e-24

Spt5 C-terminal nonapeptide repeat binding Spt4; The C-terminal domain of the transcription elongation factor protein Spt5 is necessary for binding to Spt4 to form the functional complex that regulates early transcription elongation by RNA polymerase II. The complex may be involved in pre-mRNA processing through its association with mRNA capping enzymes. This CTD domain carries a regular nonapeptide repeat that can be present in up to 18 copies, as in S. pombe. The repeat has a characteristic TPA motif.


Pssm-ID: 215026 [Multi-domain]  Cd Length: 121  Bit Score: 99.52  E-value: 1.55e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038   803 GSQTPMY-QSGSRTPMYGSQTPLYEAGSRT--PHFGGGQTPLHDG--SRTPVHGAWDPTASNTPARtELDDYTLDEGSPS 877
Cdd:smart01104    1 GGRTPAWgASGSKTPAWGSRTPGTAAGGAPtaRGGSGSRTPAWGGagSRTPAWGGAGPTGSRTPAW-GGASAWGNKSSEG 79

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*...
gi 1930395038   878 PSYqPATPGYQAPETPQGPYTPQTPGMYGsdhsySPSPTAYQPSPSPT 925
Cdd:smart01104   80 SAS-SWAAGPGGAYGAPTPGYGGTPSAYG-----PATPGGGAMAGSAS 121
KOW_Spt5_2 cd06082
KOW domain of Spt5, repeat 2; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW ...
 450-500 1.56e-22

KOW domain of Spt5, repeat 2; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW motifs at its C-terminus. Spt5 is involved in transcription elongation and termination. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KOW_Spt5 domains play critical roles in recruitment of multiple other eukaryotic transcription elongation and RNA biogenesis factors and additionally are involved in the binding of the eukaryotic Spt5 proteins to RNA polymerases.


Pssm-ID: 240506  Cd Length: 51  Bit Score: 91.41  E-value: 1.56e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1930395038  450 FAPGDNVEVAEGELVHLQGKIISIDGNKITMLPKHEDLTDPLDFQAHELKK 500
Cdd:cd06082      1 FQPGDNVEVIEGELKGLQGKVESVDGDIVTIMPKHEDLKEPLEFPAKELRK 51
KOW_Spt5_4 cd06084
KOW domain of Spt5, repeat 4; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW ...
 627-669 3.75e-21

KOW domain of Spt5, repeat 4; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW motifs at its C-terminus. Spt5 is involved in transcription elongation and termination. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KOW_Spt5 domains play critical roles in recruitment of multiple other eukaryotic transcription elongation and RNA biogenesis factors and additionally are involved in the binding of the eukaryotic Spt5 proteins to RNA polymerases.


Pssm-ID: 240508  Cd Length: 43  Bit Score: 87.19  E-value: 3.75e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1930395038  627 RDIVKVIDGPHSGRQGDVKHIFRNFAFLHSRMMLENGGIFVCK 669
Cdd:cd06084      1 GDTVKVVDGPYKGRQGTVLHIYRGTLFLHSREVTENGGIFVVR 43
KOW_Spt5_6 cd06086
KOW domain of Spt5, repeat 6; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW ...
 1025-1083 6.59e-21

KOW domain of Spt5, repeat 6; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW motifs at its C-terminus. Spt5 is involved in transcription elongation and termination. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KOW_Spt5 domains play critical roles in recruitment of multiple other eukaryotic transcription elongation and RNA biogenesis factors and additionally are involved in the binding of the eukaryotic Spt5 proteins to RNA polymerases.


Pssm-ID: 240510  Cd Length: 58  Bit Score: 86.80  E-value: 6.59e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1930395038 1025 EHLEPVPPTlRGDKVKVLMGEDREETGELLSIDMREGVVKIFSSGKITMQALRYFCKMH 1083
Cdd:cd06086      1 EHLEPVPPE-KGDRVKVIKGEDRGSTGELISIDGADGIVKMDSDGDIKILPMNFLAKLV 58
KOW_Spt5_1 cd06081
KOW domain of Spt5, repeat 1; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW ...
 306-343 2.81e-17

KOW domain of Spt5, repeat 1; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW motifs at its C-terminus. Spt5 is involved in transcription elongation and termination. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KOW_Spt5 domains play critical roles in recruitment of multiple other eukaryotic transcription elongation and RNA biogenesis factors and additionally are involved in the binding of the eukaryotic Spt5 proteins to RNA polymerases.


Pssm-ID: 240505  Cd Length: 38  Bit Score: 75.97  E-value: 2.81e-17
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1930395038  306 KQWVRLKRGIYRDDLAQVDYVDTAQGQVNLKLLPRVDY 343
Cdd:cd06081      1 GSWVRIKRGIYKGDLAQVDEVDENGNRVVVKLIPRIDY 38
CTD pfam12815
Spt5 C-terminal nonapeptide repeat binding Spt4; The C-terminal domain of the transcription ...
 803-862 3.94e-15

Spt5 C-terminal nonapeptide repeat binding Spt4; The C-terminal domain of the transcription elongation factor protein Spt5 is necessary for binding to Spt4 to form the functional complex that regulates early transcription elongation by RNA polymerase II. The complex may be involved in pre-mRNA processing through its association with mRNA capping enzymes. This CTD domain carries a regular nonapeptide repeat that can be present in up to 18 copies, as in S. pombe. The repeat has a characteriztic TPA motif.


Pssm-ID: 372327 [Multi-domain]  Cd Length: 71  Bit Score: 70.94  E-value: 3.94e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  803 GSQTPMYQS--GSRTPMY---GSQTPLY-EAGSRTPHFG-GGQTPLHD--GSRTPVH-GAWDptASNTPA 862
Cdd:pfam12815    1 GSRTPAYNSagGSRTPAWgadGSRTPAYgGAGGRTPAYNqGGKTPAWGgaGSRTPAYyGAWG--GSRTPA 68
nusG PRK08559
transcription antitermination protein NusG; Validated
 205-346 3.48e-11

transcription antitermination protein NusG; Validated


Pssm-ID: 181467 [Multi-domain]  Cd Length: 153  Bit Score: 62.58  E-value: 3.48e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  205 KDPNLWMVKCRIGEEKSTVLQMMRKFiayqySEEPLQIRSVVAPEGVKGYVYIEAYKHTHVKQCIQGIGNLRiGLYQQmM 284
Cdd:PRK08559     4 EMSMIFAVKTTAGQERNVALMLAMRA-----KKENLPIYAILAPPELKGYVLVEAESKGAVEEAIRGIPHVR-GVVPG-E 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1930395038  285 VPIKEMTDVLRVTREQAQLRPKQWVRLKRGIYRDDLAQVDYVDTAQGQVNLKLL----P-----RVDYTRP 346
Cdd:PRK08559    77 ISFEEVEHFLKPKPIVEGIKEGDIVELIAGPFKGEKARVVRVDESKEEVTVELLeaavPipvtvRGDQVRV 147
NGN smart00738
In Spt5p, this domain may confer affinity for Spt4p. It possesses a RNP-like fold; In Spt5p, ...
 208-296 1.29e-10

In Spt5p, this domain may confer affinity for Spt4p. It possesses a RNP-like fold; In Spt5p, this domain may confer affinity for Spt4p.Spt4p


Pssm-ID: 197850 [Multi-domain]  Cd Length: 106  Bit Score: 59.31  E-value: 1.29e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038   208 NLWMVKCRIGEEKSTVLQMMRKFIAYQYseePLQIRSVVAP-EGVK----------------GYVYIEAYKHTHVKQCIQ 270
Cdd:smart00738    1 NWYAVRTTSGQEKRVAENLERKAEALGL---EDKIVSILVPtEEVKeirrgkkkvverklfpGYIFVEADLEDEVWTAIR 77

                            90       100
                    ....*....|....*....|....*....
gi 1930395038   271 GIGNLRI---GLYQQMMVPIKEMTDVLRV 296
Cdd:smart00738   78 GTPGVRGfvgGGGKPTPVPDDEIEKILKP 106
PHA03291 PHA03291
envelope glycoprotein I; Provisional
 847-959 1.84e-06

envelope glycoprotein I; Provisional


Pssm-ID: 223033 [Multi-domain]  Cd Length: 401  Bit Score: 51.49  E-value: 1.84e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  847 TPVHGAWDPTASNTPARTelddytldegSPSPSYQPATPgYQAPETPQGPYTPQTPGmygsdhSYSPSPTAYQPSPSPTG 926
Cdd:PHA03291   180 GSADGSCDPALPLSAPRL----------GPADVFVPATP-RPTPRTTASPETTPTPS------TTTSPPSTTIPAPSTTI 242

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1930395038  927 YVTTPSPVTFQAGTPSPSTYG-GYSPTTPGAPSP 959
Cdd:PHA03291   243 AAPQAGTTPEAEGTPAPPTPGgGEAPPANATPAP 276
DUF3432 pfam11914
Domain of unknown function (DUF3432); This presumed domain is functionally uncharacterized. ...
 910-959 4.84e-06

Domain of unknown function (DUF3432); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 100 amino acids in length. This domain is found associated with pfam00096. This domain has two conserved sequence motifs: YPSPV and PSP.


Pssm-ID: 403204 [Multi-domain]  Cd Length: 98  Bit Score: 46.25  E-value: 4.84e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1930395038  910 SYSPSPTAYQPSPSPTGYvttPSPVTFQAGTPSPSTYGgySPTTPGAPSP 959
Cdd:pfam11914   14 SYSSSVTTSYPSPITTSY---PSPVSTSYSSPVPSSYP--SPVHTSFPSP 58
KOW_elon_Spt5 TIGR00405
transcription elongation factor Spt5; This protein contains a KOW domain, shared by bacterial ...
 212-338 1.65e-05

transcription elongation factor Spt5; This protein contains a KOW domain, shared by bacterial NusG and the uL24 (previously L24p/L26e) family of ribosomal proteins. The most recent papers and crystal structures make this a transcription elongation factor rather than a ribosomal protein.


Pssm-ID: 129499 [Multi-domain]  Cd Length: 145  Bit Score: 46.04  E-value: 1.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  212 VKCRIGEEKStVLQMMrkfiAYQYSEEPLQIRSVVAPEGVKGYVYIEAYKHTHVKQCIQGIGNLRiGLYQQmMVPIKEMT 291
Cdd:TIGR00405    3 VKTSVGQEKN-VARLM----ARKARKSGLEVYSILAPESLKGYILVEAETKIDMRNPIIGVPHVR-GVVEG-EIDFEEIE 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1930395038  292 DVLRVTREQAQLRPKQWVRLKRGIYRDDLAQVDYVDTAQGQVNLKLL 338
Cdd:TIGR00405   76 RFLTPKKIIESIKKGDIVEIISGPFKGERAKVIRVDESKEEVTLELI 122
KOW smart00739
KOW (Kyprides, Ouzounis, Woese) motif; Motif in ribosomal proteins, NusG, Spt5p, KIN17 and T54.
 501-528 4.61e-05

KOW (Kyprides, Ouzounis, Woese) motif; Motif in ribosomal proteins, NusG, Spt5p, KIN17 and T54.


Pssm-ID: 128978  Cd Length: 28  Bit Score: 41.16  E-value: 4.61e-05
                            10        20
                    ....*....|....*....|....*...
gi 1930395038   501 YFKMGDHVKVIAGRFEGDTGLIVRVEDN 528
Cdd:smart00739    1 KFEVGDTVRVIAGPFKGKVGKVLEVDGE 28
Spt5_N pfam11942
Spt5 transcription elongation factor, acidic N-terminal; This is the very acidic N-terminal ...
 128-202 1.44e-04

Spt5 transcription elongation factor, acidic N-terminal; This is the very acidic N-terminal region of the early transcription elongation factor Spt5. The Spt5-Spt4 complex regulates early transcription elongation by RNA polymerase II and has an imputed role in pre-mRNA processing via its physical association with mRNA capping enzymes. The actual function of this N-terminal domain is not known although it is dispensable for binding to Spt4.


Pssm-ID: 463406  Cd Length: 97  Bit Score: 41.87  E-value: 1.44e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1930395038  128 DGAEDMIDSHRpaeetsskELNSHRRLQMmltSQKEDEIEDYYRRKYADTTAAEggYREADVElsdEIAQQTLLP 202
Cdd:pfam11942   39 EDGRRDDRRHR--------ELDRRRELEE---DEDAEEIAEYLKERYGRSSSDA--YRGDAEE---GVPQRLLLP 97
KOW pfam00467
KOW motif; This family has been extended to coincide with ref. The KOW (Kyprides, Ouzounis, ...
 505-530 1.73e-04

KOW motif; This family has been extended to coincide with ref. The KOW (Kyprides, Ouzounis, Woese) motif is found in a variety of ribosomal proteins and NusG.


Pssm-ID: 425698 [Multi-domain]  Cd Length: 32  Bit Score: 39.68  E-value: 1.73e-04
                           10        20
                   ....*....|....*....|....*.
gi 1930395038  505 GDHVKVIAGRFEGDTGLIVRVEDNMV 530
Cdd:pfam00467    2 GDVVRVIAGPFKGKVGKVVEVDDKKN 27
KOW pfam00467
KOW motif; This family has been extended to coincide with ref. The KOW (Kyprides, Ouzounis, ...
 733-764 2.71e-04

KOW motif; This family has been extended to coincide with ref. The KOW (Kyprides, Ouzounis, Woese) motif is found in a variety of ribosomal proteins and NusG.


Pssm-ID: 425698 [Multi-domain]  Cd Length: 32  Bit Score: 39.29  E-value: 2.71e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1930395038  733 IGQTIKITQGPYKGHIGIVKDATETTARVELH 764
Cdd:pfam00467    1 KGDVVRVIAGPFKGKVGKVVEVDDKKNRVLVE 32
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
819-968 4.91e-04

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 43.97  E-value: 4.91e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  819 GSQTPLYEAGSRTPHFGGGQTPLHDGSRTPVHGAWDPTASNTPARTEL----------DDYTLDEGSPSPSYQPATPGYQ 888
Cdd:COG3469     47 GSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATATAAAAAATSTSAtlvatstasgANTGTSTVTTTSTGAGSVTSTT 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  889 APETPQGPYTPQTPGMYGSDHSYSPSPTAYQ----PSPSPTGYVTTPSPVTFQAGTPSPSTYGGYSPTTPGAPSPFNPQT 964
Cdd:COG3469    127 SSTAGSTTTSGASATSSAGSTTTTTTVSGTEtatgGTTTTSTTTTTTSASTTPSATTTATATTASGATTPSATTTATTTG 206


                   ....
gi 1930395038  965 PGAG 968
Cdd:COG3469    207 PPTP 210
KREPA2 cd23959
Kinetoplastid RNA Editing Protein A2 (KREPA2); The KREPA2 (TbMP63) protein is a component of ...
 816-973 1.72e-03

Kinetoplastid RNA Editing Protein A2 (KREPA2); The KREPA2 (TbMP63) protein is a component of the parasitic protozoan's KREPA RNA editing catalytic complex (RECC). Kinetoplastid RNA editing (KRE) proteins occur as pairs or sets of related proteins in multiple complexes. KREPA complex is composed of six components (KREPA1-6), which share a conserved C-terminal region containing an oligonucleotide-binding (OB)-fold-like domain. KREPAs are responsible for the site-specific insertion and deletion of U nucleotides in the kinetoplastid mitochondria pre-messenger RNA. Apart from the conserved C-terminal OB-fold domain, KREPA1, KREPA2, and KREPA3 contain two conserved C2H2 zinc-finger domains. KREPA2 and kinetoplastid RNA editing ligase 1 (KREL1) are specific for ligation post-U-deletion and are paralogous to KREL2 and KREPA1 that are specific for ligation post-U-insertion. KREPA2, is critical for RECC stability and KREL1 integration into the complex.


Pssm-ID: 467780 [Multi-domain]  Cd Length: 424  Bit Score: 42.16  E-value: 1.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  816 PMYGSQTPlyeAGSRTPhfgggqtplhDGSRTPVHGAWDPTASNTPARTELDDYTLDEGSPSPSYQPATPG--------- 886
Cdd:cd23959     56 PLYGAVSP---EGENPF----------DGPGLVTASTVSDCYVGNANFYEVDMSDAFAMAPDESLGPFRAArvpnpfsas 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  887 -----------YQAPETPQGPYTPQTP----GMYGSDHSYSPSPTAY---QPSPSPTGYVTTPspvtFQAGTPSPSTYgg 948
Cdd:cd23959    123 sstqrethktaQVAPPKAEPQTAPVTPfgqlPMFGQHPPPAKPLPAAaaaQQSSASPGEVASP----FASGTVSASPF-- 196

                          170       180
                   ....*....|....*....|....*
gi 1930395038  949 ySPTTPGAPSPFNPQTPGAGMEQLS 973
Cdd:cd23959    197 -ATATDTAPSSGAPDGFPAEASAPS 220
KOW pfam00467
KOW motif; This family has been extended to coincide with ref. The KOW (Kyprides, Ouzounis, ...
 628-655 4.84e-03

KOW motif; This family has been extended to coincide with ref. The KOW (Kyprides, Ouzounis, Woese) motif is found in a variety of ribosomal proteins and NusG.


Pssm-ID: 425698 [Multi-domain]  Cd Length: 32  Bit Score: 35.44  E-value: 4.84e-03
                           10        20
                   ....*....|....*....|....*...
gi 1930395038  628 DIVKVIDGPHSGRQGDVKHIFRNFAFLH 655
Cdd:pfam00467    3 DVVRVIAGPFKGKVGKVVEVDDKKNRVL 30
KOW smart00739
KOW (Kyprides, Ouzounis, Woese) motif; Motif in ribosomal proteins, NusG, Spt5p, KIN17 and T54.
 624-650 8.73e-03

KOW (Kyprides, Ouzounis, Woese) motif; Motif in ribosomal proteins, NusG, Spt5p, KIN17 and T54.


Pssm-ID: 128978  Cd Length: 28  Bit Score: 34.61  E-value: 8.73e-03
                            10        20
                    ....*....|....*....|....*..
gi 1930395038   624 IQVRDIVKVIDGPHSGRQGDVKHIFRN 650
Cdd:smart00739    2 FEVGDTVRVIAGPFKGKVGKVLEVDGE 28
 
Name Accession Description Interval E-value
NGN_Euk cd09888
Eukaryotic N-Utilization Substance G (NusG) N-terminal (NGN) domain, including plant KTF1 (KOW ...
 208-295 6.14e-40

Eukaryotic N-Utilization Substance G (NusG) N-terminal (NGN) domain, including plant KTF1 (KOW domain-containing Transcription Factor 1); The N-Utilization Substance G (NusG) protein and its eukaryotic homolog, Spt5, are involved in transcription elongation and termination. NusG contains an NGN domain at its N-terminus and Kyrpides Ouzounis and Woese (KOW) repeats at its C-terminus. Spt5 forms an Spt4-Spt5 complex that is an essential RNA polymerase II elongation factor. NusG was originally discovered as an N-dependent antitermination enhancing activity in Escherichia coli, and has a variety of functions such as its involvement in RNA polymerase elongation and Rho-termination in bacteria. Orthologs of the NusG gene exist in all bacteria, but their functions and requirements are different. Spt5-like is homologous to the Spt5 proteins present in all eukaryotes, which is unique as it encodes a protein with an additional long carboxy-terminal extension that contains WG/GW motifs. Spt5-like, or KTF1 (KOW domain-containing Transcription Factor 1), is a RNA-directed DNA methylation (RdDM) pathway effector in plants.


Pssm-ID: 193577 [Multi-domain]  Cd Length: 86  Bit Score: 142.28  E-value: 6.14e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  208 NLWMVKCRIGEEKSTVLQMMRKFIAYQYSEEPLQIRSVVAPEGVKGYVYIEAYKHTHVKQCIQGIGNLRIGlyQQMMVPI 287
Cdd:cd09888      1 KLWAVKCKPGKEREIVISLMRKFLDLQRTGNPLGIKSVFARDGLKGYIYIEARKEAHVKDAIEGLRGVYLN--TIKLVPI 78


                   ....*...
gi 1930395038  288 KEMTDVLR 295
Cdd:cd09888     79 KEMPDVLS 86
Spt5-NGN pfam03439
Early transcription elongation factor of RNA pol II, NGN section; Spt5p and prokaryotic NusG ...
 208-294 2.54e-28

Early transcription elongation factor of RNA pol II, NGN section; Spt5p and prokaryotic NusG are shown to contain a novel 'NGN' domain. The combined NGN and KOW motif regions of Spt5 form the binding domain with Spt4. Spt5 complexes with Spt4 as a 1:1 heterodimer snf this Spt5-Spt4 complex regulates early transcription elongation by RNA polymerase II and has an imputed role in pre-mRNA processing via its physical association with mRNA capping enzymes. The Schizosaccharomyces pombe core Spt5-Spt4 complex is a heterodimer bearing a trypsin-resistant Spt4-binding domain within the Spt5 subunit.


Pssm-ID: 397481  Cd Length: 84  Bit Score: 109.21  E-value: 2.54e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  208 NLWMVKCRIGEEKSTVLQMMRKFIAYQYSEEpLQIRSVVAPEGVKGYVYIEAYKHTHVKQCIQGIGNLRiGLYQQmMVPI 287
Cdd:pfam03439    1 KIWAVKCTPGQEREVALSLMRKILALAKTNN-LGIYSVFAPDGLKGYIYVEADRQAAVKRALEGIPNVR-GLVPG-LVPI 77


                   ....*..
gi 1930395038  288 KEMTDVL 294
Cdd:pfam03439   78 KEMEHLL 84
KOW_Spt5_3 cd06083
KOW domain of Spt5, repeat 3; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW ...
 501-551 7.29e-28

KOW domain of Spt5, repeat 3; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW motifs at its C-terminus. Spt5 is involved in transcription elongation and termination. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KOW_Spt5 domains play critical roles in recruitment of multiple other eukaryotic transcription elongation and RNA biogenesis factors and additionally are involved in the binding of the eukaryotic Spt5 proteins to RNA polymerases.


Pssm-ID: 240507  Cd Length: 51  Bit Score: 106.46  E-value: 7.29e-28
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1930395038  501 YFKMGDHVKVIAGRFEGDTGLIVRVEDNMVVLFSDLTMHELKVLPRDLQLC 551
Cdd:cd06083      1 HFKVGDHVKVISGRHEGETGLVVKVEDDVVTVFSDLTMRELKVFPRDLQLS 51
KOW_Spt5_5 cd06085
KOW domain of Spt5, repeat 5; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW ...
 729-779 1.08e-26

KOW domain of Spt5, repeat 5; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW motifs at its C-terminus. Spt5 is involved in transcription elongation and termination. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KOW_Spt5 domains play critical roles in recruitment of multiple other eukaryotic transcription elongation and RNA biogenesis factors and additionally are involved in the binding of the eukaryotic Spt5 proteins to RNA polymerases.


Pssm-ID: 240509  Cd Length: 52  Bit Score: 103.33  E-value: 1.08e-26
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1930395038  729 DSELIGQTIKITQGPYKGHIGIVKDATETTARVELHTKCQTISVDRSRISV 779
Cdd:cd06085      2 RDPLIGKTVRIRKGPYKGYIGIVKDATGTTARVELHSKNKTITVDRSRLAV 52
CTD smart01104
Spt5 C-terminal nonapeptide repeat binding Spt4; The C-terminal domain of the transcription ...
 803-925 1.55e-24

Spt5 C-terminal nonapeptide repeat binding Spt4; The C-terminal domain of the transcription elongation factor protein Spt5 is necessary for binding to Spt4 to form the functional complex that regulates early transcription elongation by RNA polymerase II. The complex may be involved in pre-mRNA processing through its association with mRNA capping enzymes. This CTD domain carries a regular nonapeptide repeat that can be present in up to 18 copies, as in S. pombe. The repeat has a characteristic TPA motif.


Pssm-ID: 215026 [Multi-domain]  Cd Length: 121  Bit Score: 99.52  E-value: 1.55e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038   803 GSQTPMY-QSGSRTPMYGSQTPLYEAGSRT--PHFGGGQTPLHDG--SRTPVHGAWDPTASNTPARtELDDYTLDEGSPS 877
Cdd:smart01104    1 GGRTPAWgASGSKTPAWGSRTPGTAAGGAPtaRGGSGSRTPAWGGagSRTPAWGGAGPTGSRTPAW-GGASAWGNKSSEG 79

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*...
gi 1930395038   878 PSYqPATPGYQAPETPQGPYTPQTPGMYGsdhsySPSPTAYQPSPSPT 925
Cdd:smart01104   80 SAS-SWAAGPGGAYGAPTPGYGGTPSAYG-----PATPGGGAMAGSAS 121
KOW_Spt5_2 cd06082
KOW domain of Spt5, repeat 2; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW ...
 450-500 1.56e-22

KOW domain of Spt5, repeat 2; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW motifs at its C-terminus. Spt5 is involved in transcription elongation and termination. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KOW_Spt5 domains play critical roles in recruitment of multiple other eukaryotic transcription elongation and RNA biogenesis factors and additionally are involved in the binding of the eukaryotic Spt5 proteins to RNA polymerases.


Pssm-ID: 240506  Cd Length: 51  Bit Score: 91.41  E-value: 1.56e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1930395038  450 FAPGDNVEVAEGELVHLQGKIISIDGNKITMLPKHEDLTDPLDFQAHELKK 500
Cdd:cd06082      1 FQPGDNVEVIEGELKGLQGKVESVDGDIVTIMPKHEDLKEPLEFPAKELRK 51
KOW_Spt5_4 cd06084
KOW domain of Spt5, repeat 4; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW ...
 627-669 3.75e-21

KOW domain of Spt5, repeat 4; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW motifs at its C-terminus. Spt5 is involved in transcription elongation and termination. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KOW_Spt5 domains play critical roles in recruitment of multiple other eukaryotic transcription elongation and RNA biogenesis factors and additionally are involved in the binding of the eukaryotic Spt5 proteins to RNA polymerases.


Pssm-ID: 240508  Cd Length: 43  Bit Score: 87.19  E-value: 3.75e-21
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1930395038  627 RDIVKVIDGPHSGRQGDVKHIFRNFAFLHSRMMLENGGIFVCK 669
Cdd:cd06084      1 GDTVKVVDGPYKGRQGTVLHIYRGTLFLHSREVTENGGIFVVR 43
KOW_Spt5_6 cd06086
KOW domain of Spt5, repeat 6; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW ...
 1025-1083 6.59e-21

KOW domain of Spt5, repeat 6; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW motifs at its C-terminus. Spt5 is involved in transcription elongation and termination. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KOW_Spt5 domains play critical roles in recruitment of multiple other eukaryotic transcription elongation and RNA biogenesis factors and additionally are involved in the binding of the eukaryotic Spt5 proteins to RNA polymerases.


Pssm-ID: 240510  Cd Length: 58  Bit Score: 86.80  E-value: 6.59e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1930395038 1025 EHLEPVPPTlRGDKVKVLMGEDREETGELLSIDMREGVVKIFSSGKITMQALRYFCKMH 1083
Cdd:cd06086      1 EHLEPVPPE-KGDRVKVIKGEDRGSTGELISIDGADGIVKMDSDGDIKILPMNFLAKLV 58
KOW_Spt5_1 cd06081
KOW domain of Spt5, repeat 1; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW ...
 306-343 2.81e-17

KOW domain of Spt5, repeat 1; Spt5, an eukaryotic ortholog of NusG, contains multiple KOW motifs at its C-terminus. Spt5 is involved in transcription elongation and termination. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KOW_Spt5 domains play critical roles in recruitment of multiple other eukaryotic transcription elongation and RNA biogenesis factors and additionally are involved in the binding of the eukaryotic Spt5 proteins to RNA polymerases.


Pssm-ID: 240505  Cd Length: 38  Bit Score: 75.97  E-value: 2.81e-17
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1930395038  306 KQWVRLKRGIYRDDLAQVDYVDTAQGQVNLKLLPRVDY 343
Cdd:cd06081      1 GSWVRIKRGIYKGDLAQVDEVDENGNRVVVKLIPRIDY 38
CTD pfam12815
Spt5 C-terminal nonapeptide repeat binding Spt4; The C-terminal domain of the transcription ...
 803-862 3.94e-15

Spt5 C-terminal nonapeptide repeat binding Spt4; The C-terminal domain of the transcription elongation factor protein Spt5 is necessary for binding to Spt4 to form the functional complex that regulates early transcription elongation by RNA polymerase II. The complex may be involved in pre-mRNA processing through its association with mRNA capping enzymes. This CTD domain carries a regular nonapeptide repeat that can be present in up to 18 copies, as in S. pombe. The repeat has a characteriztic TPA motif.


Pssm-ID: 372327 [Multi-domain]  Cd Length: 71  Bit Score: 70.94  E-value: 3.94e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  803 GSQTPMYQS--GSRTPMY---GSQTPLY-EAGSRTPHFG-GGQTPLHD--GSRTPVH-GAWDptASNTPA 862
Cdd:pfam12815    1 GSRTPAYNSagGSRTPAWgadGSRTPAYgGAGGRTPAYNqGGKTPAWGgaGSRTPAYyGAWG--GSRTPA 68
CTD pfam12815
Spt5 C-terminal nonapeptide repeat binding Spt4; The C-terminal domain of the transcription ...
 812-882 1.28e-12

Spt5 C-terminal nonapeptide repeat binding Spt4; The C-terminal domain of the transcription elongation factor protein Spt5 is necessary for binding to Spt4 to form the functional complex that regulates early transcription elongation by RNA polymerase II. The complex may be involved in pre-mRNA processing through its association with mRNA capping enzymes. This CTD domain carries a regular nonapeptide repeat that can be present in up to 18 copies, as in S. pombe. The repeat has a characteriztic TPA motif.


Pssm-ID: 372327 [Multi-domain]  Cd Length: 71  Bit Score: 64.00  E-value: 1.28e-12
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1930395038  812 GSRTPMY----GSQTPLYEA-GSRTPHFG--GGQTPL-HDGSRTPvhgAWDPTASNTPARtelddYTLDEGSPSPSYQP 882
Cdd:pfam12815    1 GSRTPAYnsagGSRTPAWGAdGSRTPAYGgaGGRTPAyNQGGKTP---AWGGAGSRTPAY-----YGAWGGSRTPAYGG 71
nusG PRK08559
transcription antitermination protein NusG; Validated
 205-346 3.48e-11

transcription antitermination protein NusG; Validated


Pssm-ID: 181467 [Multi-domain]  Cd Length: 153  Bit Score: 62.58  E-value: 3.48e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  205 KDPNLWMVKCRIGEEKSTVLQMMRKFiayqySEEPLQIRSVVAPEGVKGYVYIEAYKHTHVKQCIQGIGNLRiGLYQQmM 284
Cdd:PRK08559     4 EMSMIFAVKTTAGQERNVALMLAMRA-----KKENLPIYAILAPPELKGYVLVEAESKGAVEEAIRGIPHVR-GVVPG-E 76

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1930395038  285 VPIKEMTDVLRVTREQAQLRPKQWVRLKRGIYRDDLAQVDYVDTAQGQVNLKLL----P-----RVDYTRP 346
Cdd:PRK08559    77 ISFEEVEHFLKPKPIVEGIKEGDIVELIAGPFKGEKARVVRVDESKEEVTVELLeaavPipvtvRGDQVRV 147
CTD smart01104
Spt5 C-terminal nonapeptide repeat binding Spt4; The C-terminal domain of the transcription ...
 796-908 7.21e-11

Spt5 C-terminal nonapeptide repeat binding Spt4; The C-terminal domain of the transcription elongation factor protein Spt5 is necessary for binding to Spt4 to form the functional complex that regulates early transcription elongation by RNA polymerase II. The complex may be involved in pre-mRNA processing through its association with mRNA capping enzymes. This CTD domain carries a regular nonapeptide repeat that can be present in up to 18 copies, as in S. pombe. The repeat has a characteristic TPA motif.


Pssm-ID: 215026 [Multi-domain]  Cd Length: 121  Bit Score: 60.61  E-value: 7.21e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038   796 RTPMYG-SGSQTPMY---------------------------QSGSRTPMYGSQTPlyeAGSRTPHFGGGQTPlhdgsrt 847
Cdd:smart01104    3 RTPAWGaSGSKTPAWgsrtpgtaaggaptarggsgsrtpawgGAGSRTPAWGGAGP---TGSRTPAWGGASAW------- 72

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1930395038   848 pvHGAWDPTASNTPARTelddytldegsPSPSYQPATPGYQAPETPQGPYTPQTPGMYGSD 908
Cdd:smart01104   73 --GNKSSEGSASSWAAG-----------PGGAYGAPTPGYGGTPSAYGPATPGGGAMAGSA 120
NGN smart00738
In Spt5p, this domain may confer affinity for Spt4p. It possesses a RNP-like fold; In Spt5p, ...
 208-296 1.29e-10

In Spt5p, this domain may confer affinity for Spt4p. It possesses a RNP-like fold; In Spt5p, this domain may confer affinity for Spt4p.Spt4p


Pssm-ID: 197850 [Multi-domain]  Cd Length: 106  Bit Score: 59.31  E-value: 1.29e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038   208 NLWMVKCRIGEEKSTVLQMMRKFIAYQYseePLQIRSVVAP-EGVK----------------GYVYIEAYKHTHVKQCIQ 270
Cdd:smart00738    1 NWYAVRTTSGQEKRVAENLERKAEALGL---EDKIVSILVPtEEVKeirrgkkkvverklfpGYIFVEADLEDEVWTAIR 77

                            90       100
                    ....*....|....*....|....*....
gi 1930395038   271 GIGNLRI---GLYQQMMVPIKEMTDVLRV 296
Cdd:smart00738   78 GTPGVRGfvgGGGKPTPVPDDEIEKILKP 106
NGN_Arch cd09887
Archaeal N-Utilization Substance G (NusG) N-terminal (NGN) domain; The N-Utilization Substance ...
 209-290 2.63e-08

Archaeal N-Utilization Substance G (NusG) N-terminal (NGN) domain; The N-Utilization Substance G (NusG) protein and its eukaryotic homolog, Spt5, are involved in transcription elongation and termination. Transcription in archaea has a eukaryotic-type transcription apparatus, but contains bacterial-type transcription factors. NusG is one of the few archaeal transcription factors that has orthologs in both bacteria and eukaryotes. Archaeal NusG is similar to bacterial NusG, composed of an NGN domain and a Kyrpides Ouzounis and Woese (KOW) repeat. The eukaryotic ortholog, Spt5, is a large protein composed of an acidic N-terminus, an NGN domain, and multiple KOW motifs at its C-terminus. NusG was originally discovered as a N-dependent antitermination enhancing activity in Escherichia coli and has a variety of functions, such as being involved in RNA polymerase elongation and Rho-termination in bacteria. Archaeal NusG forms a complex with DNA-directed RNA polymerase subunit E (rpoE) that is similar to the Spt5-Spt4 complex in eukaryotes.


Pssm-ID: 193576  Cd Length: 82  Bit Score: 52.16  E-value: 2.63e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  209 LWMVKCRIGEEKsTVLQMMRKFIAyqysEEPLQIRSVVAPEGVKGYVYIEAYKHTHVKQCIQGIGNLRIGLyqQMMVPIK 288
Cdd:cd09887      2 IYAVKTTAGQER-NVADLLAMRAE----KENLDVYSILVPEELKGYVFVEAEDPDRVEELIRGIPHVRGVV--PGEISLE 74


                   ..
gi 1930395038  289 EM 290
Cdd:cd09887     75 EI 76
CTD pfam12815
Spt5 C-terminal nonapeptide repeat binding Spt4; The C-terminal domain of the transcription ...
 794-836 4.47e-08

Spt5 C-terminal nonapeptide repeat binding Spt4; The C-terminal domain of the transcription elongation factor protein Spt5 is necessary for binding to Spt4 to form the functional complex that regulates early transcription elongation by RNA polymerase II. The complex may be involved in pre-mRNA processing through its association with mRNA capping enzymes. This CTD domain carries a regular nonapeptide repeat that can be present in up to 18 copies, as in S. pombe. The repeat has a characteriztic TPA motif.


Pssm-ID: 372327 [Multi-domain]  Cd Length: 71  Bit Score: 50.91  E-value: 4.47e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1930395038  794 YNRTPMYG-SGSQTPMYQSGSRTPMY---GSQTPLYEA---GSRTPHFGG 836
Cdd:pfam12815   22 GSRTPAYGgAGGRTPAYNQGGKTPAWggaGSRTPAYYGawgGSRTPAYGG 71
KOW cd00380
KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); KOW domain is known ...
 505-549 9.22e-07

KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. The KOW motif contains an invariants glycine residue and comprises alternating blocks of hydrophilic and hydrophobic residues.


Pssm-ID: 240504  Cd Length: 49  Bit Score: 46.44  E-value: 9.22e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1930395038  505 GDHVKVIAGRFEGDTGLIVRVED----NMVVLFSDLTMHELKVLPRDLQ 549
Cdd:cd00380      1 GDVVRVLRGPYKGREGVVVDIDPrfgiVTVKGATGSKGAELKVRFDDVD 49
PHA03291 PHA03291
envelope glycoprotein I; Provisional
 847-959 1.84e-06

envelope glycoprotein I; Provisional


Pssm-ID: 223033 [Multi-domain]  Cd Length: 401  Bit Score: 51.49  E-value: 1.84e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  847 TPVHGAWDPTASNTPARTelddytldegSPSPSYQPATPgYQAPETPQGPYTPQTPGmygsdhSYSPSPTAYQPSPSPTG 926
Cdd:PHA03291   180 GSADGSCDPALPLSAPRL----------GPADVFVPATP-RPTPRTTASPETTPTPS------TTTSPPSTTIPAPSTTI 242

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1930395038  927 YVTTPSPVTFQAGTPSPSTYG-GYSPTTPGAPSP 959
Cdd:PHA03291   243 AAPQAGTTPEAEGTPAPPTPGgGEAPPANATPAP 276
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 855-959 2.58e-06

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 51.84  E-value: 2.58e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  855 PTASNTPARTELDDYTLDEGSPSPS-----YQPATPG---------YQAPE--TPQGPYTPQTPgmygsdHSYSPSPTAY 918
Cdd:pfam05109  455 PTNLTAPASTGPTVSTADVTSPTPAgttsgASPVTPSpsprdngteSKAPDmtSPTSAVTTPTP------NATSPTPAVT 528

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1930395038  919 QPSP----------SPTGYVTTPSP----VTFQAGTPSPS----TYGGYSPT------TPGAPSP 959
Cdd:pfam05109  529 TPTPnatsptlgktSPTSAVTTPTPnatsPTPAVTTPTPNatipTLGKTSPTsavttpTPNATSP 593
DUF3432 pfam11914
Domain of unknown function (DUF3432); This presumed domain is functionally uncharacterized. ...
 910-959 4.84e-06

Domain of unknown function (DUF3432); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is about 100 amino acids in length. This domain is found associated with pfam00096. This domain has two conserved sequence motifs: YPSPV and PSP.


Pssm-ID: 403204 [Multi-domain]  Cd Length: 98  Bit Score: 46.25  E-value: 4.84e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1930395038  910 SYSPSPTAYQPSPSPTGYvttPSPVTFQAGTPSPSTYGgySPTTPGAPSP 959
Cdd:pfam11914   14 SYSSSVTTSYPSPITTSY---PSPVSTSYSSPVPSSYP--SPVHTSFPSP 58
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 874-972 8.46e-06

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 50.01  E-value: 8.46e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  874 GSPSP----SYQPATP--GYQAPETPQGPYtPQTPGmygSDHSYSPSPtayQPSPSPtGYVTTPSPVTFQaGTPSPSTYG 947
Cdd:pfam09606  374 SSPSPvpgqQVRQVTPnqFMRQSPQPSVPS-PQGPG---SQPPQSHPG---GMIPSP-ALIPSPSPQMSQ-QPAQQRTIG 444

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1930395038  948 GYSP----TTPG---APSPFNPQTPGAGMEQL 972
Cdd:pfam09606  445 QDSPggslNTPGqsaVNSPLNPQEEQLYREKY 476
KOW_elon_Spt5 TIGR00405
transcription elongation factor Spt5; This protein contains a KOW domain, shared by bacterial ...
 212-338 1.65e-05

transcription elongation factor Spt5; This protein contains a KOW domain, shared by bacterial NusG and the uL24 (previously L24p/L26e) family of ribosomal proteins. The most recent papers and crystal structures make this a transcription elongation factor rather than a ribosomal protein.


Pssm-ID: 129499 [Multi-domain]  Cd Length: 145  Bit Score: 46.04  E-value: 1.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  212 VKCRIGEEKStVLQMMrkfiAYQYSEEPLQIRSVVAPEGVKGYVYIEAYKHTHVKQCIQGIGNLRiGLYQQmMVPIKEMT 291
Cdd:TIGR00405    3 VKTSVGQEKN-VARLM----ARKARKSGLEVYSILAPESLKGYILVEAETKIDMRNPIIGVPHVR-GVVEG-EIDFEEIE 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1930395038  292 DVLRVTREQAQLRPKQWVRLKRGIYRDDLAQVDYVDTAQGQVNLKLL 338
Cdd:TIGR00405   76 RFLTPKKIIESIKKGDIVEIISGPFKGERAKVIRVDESKEEVTLELI 122
NGN cd08000
N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; The N-Utilization ...
 208-294 3.35e-05

N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; The N-Utilization Substance G (NusG) and its eukaryotic homolog Spt5 are involved in transcription elongation and termination. NusG contains an NGN domain at its N-terminus and Kyrpides Ouzounis and Woese (KOW) repeats at its C-terminus in bacteria and archaea. The eukaryotic ortholog, Spt5, is a large protein composed of an acidic N-terminus, an NGN domain, and multiple KOW motifs at its C-terminus. Spt5 forms a Spt4-Spt5 complex that is an essential RNA Polymerase II elongation factor. NusG was originally discovered as an N-dependent antitermination enhancing activity in Escherichia coli and has a variety of functions, such as being involved in RNA polymerase elongation and Rho-termination in bacteria. Orthologs of the NusG gene exist in all bacteria, but its functions and requirements are different. The diverse activities suggest that, after diverging from a common ancestor, NusG proteins became specialized in different bacteria.


Pssm-ID: 193574 [Multi-domain]  Cd Length: 99  Bit Score: 43.85  E-value: 3.35e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  208 NLWMVKCRIGEEKSTVLQMMRKFIA---------YQYSEEPLQIRSVVAPEGVKGYVYIEAYKHTHVKQCIQGIGNLR-- 276
Cdd:cd08000      1 NWYVLFVKTGREEKVEKLLEKRFEAndieafvpkKEVPERKRGKIEEVIKPLFPGYVFVETDLSPELYELIREVPGVIgi 80

                           90
                   ....*....|....*....
gi 1930395038  277 -IGLYQQMMVPIKEMTDVL 294
Cdd:cd08000     81 lGNGEEPSPVSDEEIEMIL 99
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 839-959 3.75e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 47.99  E-value: 3.75e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  839 TPLHDGSRTPVHGAWDPT-ASNTPartelddyTLDEGSPSPSYQPATPGYQAPE----TPQGPYTPQTPgmygsdHSYSP 913
Cdd:pfam05109  493 SPRDNGTESKAPDMTSPTsAVTTP--------TPNATSPTPAVTTPTPNATSPTlgktSPTSAVTTPTP------NATSP 558

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1930395038  914 SPTAYQPSP----------SPTGYVTTPSP--VTFQAGTPSPS------TYGGYSpTTPGAPSP 959
Cdd:pfam05109  559 TPAVTTPTPnatiptlgktSPTSAVTTPTPnaTSPTVGETSPQanttnhTLGGTS-STPVVTSP 621
KOW smart00739
KOW (Kyprides, Ouzounis, Woese) motif; Motif in ribosomal proteins, NusG, Spt5p, KIN17 and T54.
 501-528 4.61e-05

KOW (Kyprides, Ouzounis, Woese) motif; Motif in ribosomal proteins, NusG, Spt5p, KIN17 and T54.


Pssm-ID: 128978  Cd Length: 28  Bit Score: 41.16  E-value: 4.61e-05
                            10        20
                    ....*....|....*....|....*...
gi 1930395038   501 YFKMGDHVKVIAGRFEGDTGLIVRVEDN 528
Cdd:smart00739    1 KFEVGDTVRVIAGPFKGKVGKVLEVDGE 28
dnaA PRK14086
chromosomal replication initiator protein DnaA;
854-980 6.61e-05

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 47.13  E-value: 6.61e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  854 DPTASNTPARTELDDYTLDEGSPSPSYQPaTPGYQAPE-TPQGPYTPQTPGMYGSdhsySPSPTAYQPSPSPTGYVTTPS 932
Cdd:PRK14086    89 DPSAGEPAPPPPHARRTSEPELPRPGRRP-YEGYGGPRaDDRPPGLPRQDQLPTA----RPAYPAYQQRPEPGAWPRAAD 163

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1930395038  933 PVTFQ---AGTPSPSTYGgySPTTPGAPSPFNPQTPGAGMEQLSVEWQSVD 980
Cdd:PRK14086   164 DYGWQqqrLGFPPRAPYA--SPASYAPEQERDREPYDAGRPEYDQRRRDYD 212
PHA03247 PHA03247
large tegument protein UL36; Provisional
 878-978 8.94e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 8.94e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  878 PSYQPATPgyQAPETPQGPYTPQTPGMYGSDHSYSPSPTAYQPSPSPTGYVTTPSPVTfqAGTPsPSTYGGYSPTTPGAP 957
Cdd:PHA03247  2701 PPPPPPTP--EPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPAR--PARP-PTTAGPPAPAPPAAP 2775

                           90       100
                   ....*....|....*....|..
gi 1930395038  958 -SPFNPQTPGAGMEQLSVEWQS 978
Cdd:PHA03247  2776 aAGPPRRLTRPAVASLSESRES 2797
Spt5_N pfam11942
Spt5 transcription elongation factor, acidic N-terminal; This is the very acidic N-terminal ...
 128-202 1.44e-04

Spt5 transcription elongation factor, acidic N-terminal; This is the very acidic N-terminal region of the early transcription elongation factor Spt5. The Spt5-Spt4 complex regulates early transcription elongation by RNA polymerase II and has an imputed role in pre-mRNA processing via its physical association with mRNA capping enzymes. The actual function of this N-terminal domain is not known although it is dispensable for binding to Spt4.


Pssm-ID: 463406  Cd Length: 97  Bit Score: 41.87  E-value: 1.44e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1930395038  128 DGAEDMIDSHRpaeetsskELNSHRRLQMmltSQKEDEIEDYYRRKYADTTAAEggYREADVElsdEIAQQTLLP 202
Cdd:pfam11942   39 EDGRRDDRRHR--------ELDRRRELEE---DEDAEEIAEYLKERYGRSSSDA--YRGDAEE---GVPQRLLLP 97
KOW pfam00467
KOW motif; This family has been extended to coincide with ref. The KOW (Kyprides, Ouzounis, ...
 505-530 1.73e-04

KOW motif; This family has been extended to coincide with ref. The KOW (Kyprides, Ouzounis, Woese) motif is found in a variety of ribosomal proteins and NusG.


Pssm-ID: 425698 [Multi-domain]  Cd Length: 32  Bit Score: 39.68  E-value: 1.73e-04
                           10        20
                   ....*....|....*....|....*.
gi 1930395038  505 GDHVKVIAGRFEGDTGLIVRVEDNMV 530
Cdd:pfam00467    2 GDVVRVIAGPFKGKVGKVVEVDDKKN 27
PHA03247 PHA03247
large tegument protein UL36; Provisional
 832-968 2.34e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 2.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  832 PHFGGGQTPLHDGsrTPVHGAWDPTASNTPARTELDDYTLDEGSPSPSYQPATP-GYQAPETPQGPYTPQTPGMYGSDHS 910
Cdd:PHA03247  2712 PHALVSATPLPPG--PAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTaGPPAPAPPAAPAAGPPRRLTRPAVA 2789

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1930395038  911 YSPSPTAYQPSPSPTGYVTTPSPVTFQAGTPSPSTYGGYSPTT-------PGAPSPFNPQTPGAG 968
Cdd:PHA03247  2790 SLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTsaqptapPPPPGPPPPSLPLGG 2854
KOW pfam00467
KOW motif; This family has been extended to coincide with ref. The KOW (Kyprides, Ouzounis, ...
 733-764 2.71e-04

KOW motif; This family has been extended to coincide with ref. The KOW (Kyprides, Ouzounis, Woese) motif is found in a variety of ribosomal proteins and NusG.


Pssm-ID: 425698 [Multi-domain]  Cd Length: 32  Bit Score: 39.29  E-value: 2.71e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1930395038  733 IGQTIKITQGPYKGHIGIVKDATETTARVELH 764
Cdd:pfam00467    1 KGDVVRVIAGPFKGKVGKVVEVDDKKNRVLVE 32
PHA03378 PHA03378
EBNA-3B; Provisional
 793-971 4.66e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 44.29  E-value: 4.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  793 TYNRTPMYGSGSQTPM-YQSGSRTPMYGSQTPLYEAGSRTPHfgggQTPLHDGSRTPVHGAWDPTASNTPARTELDDYTL 871
Cdd:PHA03378   611 TQSHIPETSAPRQWPMpLRPIPMRPLRMQPITFNVLVFPTPH----QPPQVEITPYKPTWTQIGHIPYQPSPTGANTMLP 686

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  872 DEGSPSPSYQPA-TPGYQAPetPQGPYTPQTP--GMYGSDHSYSPSPTAYQPSPSPTGYVTTPSPVTFQAGTPSPSTYGG 948
Cdd:PHA03378   687 IQWAPGTMQPPPrAPTPMRP--PAAPPGRAQRpaAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRA 764

                          170       180
                   ....*....|....*....|....*
gi 1930395038  949 YSPT-TPGAPSPF-NPQTPGAGMEQ 971
Cdd:PHA03378   765 RPPAaAPGAPTPQpPPQAPPAPQQR 789
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
819-968 4.91e-04

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 43.97  E-value: 4.91e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  819 GSQTPLYEAGSRTPHFGGGQTPLHDGSRTPVHGAWDPTASNTPARTEL----------DDYTLDEGSPSPSYQPATPGYQ 888
Cdd:COG3469     47 GSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATATAAAAAATSTSAtlvatstasgANTGTSTVTTTSTGAGSVTSTT 126

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  889 APETPQGPYTPQTPGMYGSDHSYSPSPTAYQ----PSPSPTGYVTTPSPVTFQAGTPSPSTYGGYSPTTPGAPSPFNPQT 964
Cdd:COG3469    127 SSTAGSTTTSGASATSSAGSTTTTTTVSGTEtatgGTTTTSTTTTTTSASTTPSATTTATATTASGATTPSATTTATTTG 206


                   ....
gi 1930395038  965 PGAG 968
Cdd:COG3469    207 PPTP 210
RCR pfam12273
Chitin synthesis regulation, resistance to Congo red; RCR proteins are ER membrane proteins ...
 871-957 4.98e-04

Chitin synthesis regulation, resistance to Congo red; RCR proteins are ER membrane proteins that regulate chitin deposition in fungal cell walls. Although chitin, a linear polymer of beta-1,4-linked N-acetylglucosamine, constitutes only 2% of the cell wall it plays a vital role in the overall protection of the cell wall against stress, noxious chemicals and osmotic pressure changes. Congo red is a cell wall-disrupting benzidine-type dye extensively used in many cell wall mutant studies that specifically targets chitin in yeast cells and inhibits growth. RCR proteins render the yeasts resistant to Congo red by diminishing the content of chitin in the cell wall. RCR proteins are probably regulating chitin synthase III interact directly with ubiquitin ligase Rsp5, and the VPEY motif is necessary for this, via interaction with the WW domains of Rsp5.


Pssm-ID: 432443 [Multi-domain]  Cd Length: 113  Bit Score: 40.86  E-value: 4.98e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  871 LDEGSPSPSYQPATPGYQAPETPQGPYTPQTpGMYGSDHSYSPSPTAYQPsPSPTGYVTTpspvtfqagtpSPSTYGGYS 950
Cdd:pfam12273   40 MGGGPPPPSYGQSQQDPQPTGTYVPTYTPND-GYYDQQGNFHNAGSGLQP-PQQAYQPPT-----------SSEGDPDYA 106


                   ....*..
gi 1930395038  951 PtTPGAP 957
Cdd:pfam12273  107 P-PAGPP 112
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 829-979 5.30e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 44.21  E-value: 5.30e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  829 SRTPHFGGGQTPlhDGSRTPVHGAwDPTASNTPARTElddytlDEGSPSPSYQPATPGYQAPETPQGPytPQTPGMYGSD 908
Cdd:PRK07764   383 RRLGVAGGAGAP--AAAAPSAAAA-APAAAPAPAAAA------PAAAAAPAPAAAPQPAPAPAPAPAP--PSPAGNAPAG 451

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1930395038  909 HSYSPSPTAyQPSPSPTGyVTTPSPVTFQAGTPSPSTyGGYSPTTPGAPSPFNPQTPGAGMEQLSVEWQSV 979
Cdd:PRK07764   452 GAPSPPPAA-APSAQPAP-APAAAPEPTAAPAPAPPA-APAPAAAPAAPAAPAAPAGADDAATLRERWPEI 519
PHA03247 PHA03247
large tegument protein UL36; Provisional
 806-967 6.82e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 6.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  806 TPMYQSGSRTPMYGSQTPLYEAGSRTPHFGGGQTPLhdGSRTPVHGAWDPTASNTPARTELDDYTLDEGSPSPSYQPATP 885
Cdd:PHA03247  2722 PPGPAAARQASPALPAAPAPPAVPAGPATPGGPARP--ARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLP 2799

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  886 GYQAPETPQGPYTPQTPGMYGSDH--SYSPSPTAYQPSPSPTGYVTTPSPVTFQAGTPSPSTYGGYSPTTPGAPSPFNPQ 963
Cdd:PHA03247  2800 SPWDPADPPAAVLAPAAALPPAASpaGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPA 2879


                   ....
gi 1930395038  964 TPGA 967
Cdd:PHA03247  2880 RPPV 2883
PHA03247 PHA03247
large tegument protein UL36; Provisional
 840-967 9.23e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 9.23e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  840 PLHDGSRTPvhgawDPTASNTPARTELDDYTLDEGSPSPSYQPATPGYQAPETPQGPYTPQTPGmyGSDHSYSPSPTAYQ 919
Cdd:PHA03247  2694 SLTSLADPP-----PPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPG--GPARPARPPTTAGP 2766

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1930395038  920 PSPS-PTGYVTTPSPVTfqagtpSPSTYGGYSPTTPGAPSPFNPQTPGA 967
Cdd:PHA03247  2767 PAPApPAAPAAGPPRRL------TRPAVASLSESRESLPSPWDPADPPA 2809
KOW cd00380
KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); KOW domain is known ...
 628-665 1.03e-03

KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. The KOW motif contains an invariants glycine residue and comprises alternating blocks of hydrophilic and hydrophobic residues.


Pssm-ID: 240504  Cd Length: 49  Bit Score: 37.97  E-value: 1.03e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1930395038  628 DIVKVIDGPHSGRQGDVKHIFRNFAFLHsrMMLENGGI 665
Cdd:cd00380      2 DVVRVLRGPYKGREGVVVDIDPRFGIVT--VKGATGSK 37
KREPA2 cd23959
Kinetoplastid RNA Editing Protein A2 (KREPA2); The KREPA2 (TbMP63) protein is a component of ...
 816-973 1.72e-03

Kinetoplastid RNA Editing Protein A2 (KREPA2); The KREPA2 (TbMP63) protein is a component of the parasitic protozoan's KREPA RNA editing catalytic complex (RECC). Kinetoplastid RNA editing (KRE) proteins occur as pairs or sets of related proteins in multiple complexes. KREPA complex is composed of six components (KREPA1-6), which share a conserved C-terminal region containing an oligonucleotide-binding (OB)-fold-like domain. KREPAs are responsible for the site-specific insertion and deletion of U nucleotides in the kinetoplastid mitochondria pre-messenger RNA. Apart from the conserved C-terminal OB-fold domain, KREPA1, KREPA2, and KREPA3 contain two conserved C2H2 zinc-finger domains. KREPA2 and kinetoplastid RNA editing ligase 1 (KREL1) are specific for ligation post-U-deletion and are paralogous to KREL2 and KREPA1 that are specific for ligation post-U-insertion. KREPA2, is critical for RECC stability and KREL1 integration into the complex.


Pssm-ID: 467780 [Multi-domain]  Cd Length: 424  Bit Score: 42.16  E-value: 1.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  816 PMYGSQTPlyeAGSRTPhfgggqtplhDGSRTPVHGAWDPTASNTPARTELDDYTLDEGSPSPSYQPATPG--------- 886
Cdd:cd23959     56 PLYGAVSP---EGENPF----------DGPGLVTASTVSDCYVGNANFYEVDMSDAFAMAPDESLGPFRAArvpnpfsas 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  887 -----------YQAPETPQGPYTPQTP----GMYGSDHSYSPSPTAY---QPSPSPTGYVTTPspvtFQAGTPSPSTYgg 948
Cdd:cd23959    123 sstqrethktaQVAPPKAEPQTAPVTPfgqlPMFGQHPPPAKPLPAAaaaQQSSASPGEVASP----FASGTVSASPF-- 196

                          170       180
                   ....*....|....*....|....*
gi 1930395038  949 ySPTTPGAPSPFNPQTPGAGMEQLS 973
Cdd:cd23959    197 -ATATDTAPSSGAPDGFPAEASAPS 220
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 876-987 2.12e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 42.10  E-value: 2.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1930395038  876 PSPSYQPATPGYQAPETPQG---PYTPQTPGMYGSDHSYSPSPTAYQPSPSPTGYVTTPSPVTFQAGTPSPSTyGGYSPT 952
Cdd:PRK14950   362 PVPAPQPAKPTAAAPSPVRPtpaPSTRPKAAAAANIPPKEPVRETATPPPVPPRPVAPPVPHTPESAPKLTRA-AIPVDE 440

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1930395038  953 TPGAPSPFNPQT-------PGAGMEQLSVEWQSVDLEVRIKD 987
Cdd:PRK14950   441 KPKYTPPAPPKEeekaliaDGDVLEQLEAIWKQILRDVPPRS 482
KOW pfam00467
KOW motif; This family has been extended to coincide with ref. The KOW (Kyprides, Ouzounis, ...
 628-655 4.84e-03

KOW motif; This family has been extended to coincide with ref. The KOW (Kyprides, Ouzounis, Woese) motif is found in a variety of ribosomal proteins and NusG.


Pssm-ID: 425698 [Multi-domain]  Cd Length: 32  Bit Score: 35.44  E-value: 4.84e-03
                           10        20
                   ....*....|....*....|....*...
gi 1930395038  628 DIVKVIDGPHSGRQGDVKHIFRNFAFLH 655
Cdd:pfam00467    3 DVVRVIAGPFKGKVGKVVEVDDKKNRVL 30
KOW smart00739
KOW (Kyprides, Ouzounis, Woese) motif; Motif in ribosomal proteins, NusG, Spt5p, KIN17 and T54.
 624-650 8.73e-03

KOW (Kyprides, Ouzounis, Woese) motif; Motif in ribosomal proteins, NusG, Spt5p, KIN17 and T54.


Pssm-ID: 128978  Cd Length: 28  Bit Score: 34.61  E-value: 8.73e-03
                            10        20
                    ....*....|....*....|....*..
gi 1930395038   624 IQVRDIVKVIDGPHSGRQGDVKHIFRN 650
Cdd:smart00739    2 FEVGDTVRVIAGPFKGKVGKVLEVDGE 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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