NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1926336831|ref|XP_036861200|]
View 

6-phosphogluconolactonase isoform X1 [Manis javanica]

Protein Classification

6-phosphogluconolactonase( domain architecture ID 10796786)

6-phosphogluconolactonase catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate, which is the the second step of the oxidative phase of the pentose phosphate pathway

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 11-248 4.30e-95

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


:

Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 278.87  E-value: 4.30e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831  11 VFSSPQELGASLAQLVAQRAACCLAgARARFALGLSGGSLVSMLARDLPAAAAPAGpaslaRWTVGFCDERLVPFEHAES 90
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALA-ERGQFSLALSGGRSPIALLEALAAQPLDWS-----RIHLFLGDERYVPLDHADS 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831  91 TYGLYRTHLLSRLPIPDSQVITINPQLP-VEEAAEDYAKKLRQAFQGDSIPVFDLLILGVGPDGHTCSLFPNHPLLQERE 169
Cdd:TIGR01198  75 NTGLAREALLDRVAIPASNIHPMPTELSdIEEAAELYEQELAAAFQPIVFPVFDLLLLGMGPDGHTASLFPHTPALQETE 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1926336831 170 KIVAPISDSPKPPPHRVTLTLPVLNAARTVIFVATGESKAAVLKRILEDKEENPLPATLVQPHTGKLCWFLDEAAARLL 248
Cdd:TIGR01198 155 RLVTVLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYPLPAAGVLHSGKTLWLLDYAAARKL 233
 
Name Accession Description Interval E-value
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 11-248 4.30e-95

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 278.87  E-value: 4.30e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831  11 VFSSPQELGASLAQLVAQRAACCLAgARARFALGLSGGSLVSMLARDLPAAAAPAGpaslaRWTVGFCDERLVPFEHAES 90
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALA-ERGQFSLALSGGRSPIALLEALAAQPLDWS-----RIHLFLGDERYVPLDHADS 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831  91 TYGLYRTHLLSRLPIPDSQVITINPQLP-VEEAAEDYAKKLRQAFQGDSIPVFDLLILGVGPDGHTCSLFPNHPLLQERE 169
Cdd:TIGR01198  75 NTGLAREALLDRVAIPASNIHPMPTELSdIEEAAELYEQELAAAFQPIVFPVFDLLLLGMGPDGHTASLFPHTPALQETE 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1926336831 170 KIVAPISDSPKPPPHRVTLTLPVLNAARTVIFVATGESKAAVLKRILEDKEENPLPATLVQPHTGKLCWFLDEAAARLL 248
Cdd:TIGR01198 155 RLVTVLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYPLPAAGVLHSGKTLWLLDYAAARKL 233
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 16-240 2.48e-90

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 265.96  E-value: 2.48e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831  16 QELGASLAQLVAQRAACCLAgARARFALGLSGGSLVSMLARDLPAAAAPAGPaslaRWTVGFCDERLVPFEHAESTYGLY 95
Cdd:cd01400     1 EALAEALADRIAEALAAAIA-KRGRFSLALSGGSTPKPLYELLAAAPALDWS----KVHVFLGDERCVPPDDPDSNYRLA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831  96 RTHLLSRLPIPDSQVITINPQLPVEEAAEDYAKKLRQAFqgDSIPVFDLLILGVGPDGHTCSLFPNHP-LLQEREKIVAP 174
Cdd:cd01400    76 REALLSHVAIPAANIHPIPTELGPEDAAAAYEKELRALF--GGVPPFDLVLLGMGPDGHTASLFPGHPaLLEETDRLVVA 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1926336831 175 ISDSPKPPPHRVTLTLPVLNAARTVIFVATGESKAAVLKRILEDKEENPLPATLVQPHTGKLCWFL 240
Cdd:cd01400   154 VTDSPKPPPERITLTLPVLNNARRVVFLVTGAEKAEALKRALAGPDPEELPAARVLPRPGEVLWFL 219
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
13-238 1.88e-89

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 264.10  E-value: 1.88e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831  13 SSPQELGASLAQLVAQRAACCLAgARARFALGLSGGSLVSMLARDLPAAAAPAGPAslaRWTVGFCDERLVPFEHAESTY 92
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAALA-ERGRFTLALSGGSTPKPLYELLAAAPARLDWS---RVHVFWGDERCVPPDDPDSNY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831  93 GLYRTHLLSRLPIPDSQVITIN-PQLPVEEAAEDYAKKLRQAFQGDSIPVFDLLILGVGPDGHTCSLFPNHPLLQEREKI 171
Cdd:pfam01182  77 GMAREALLSHVPIPASNVHPIPaSAADPEEAAAAYEAELRELLPDLELPVFDLVLLGMGPDGHTASLFPGSPALEETDRL 156

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1926336831 172 VAPISDSPKPPPHRVTLTLPVLNAARTVIFVATGESKAAVLKRILEDkEENPLPATLVQPHTGKLCW 238
Cdd:pfam01182 157 VVAVTDSPKPPPERITLTLPVLNAARRVWFLVTGAGKADALRRALAG-DPDPLPAALVRPGAGETVW 222
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 7-248 3.46e-68

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 211.64  E-value: 3.46e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831   7 CLISVFSSPQELGASLAQLVAQRAACCLAgARARFALGLSGGSLVSMLARDLPAAAAPAGPASlaRWTVGFCDERLVPFE 86
Cdd:PLN02360   11 GEIRVHENLDELSTDLAEYIAELSEASVK-ERGVFAIALSGGSLISFMGKLCEAPYNKTVDWA--KWYIFWADERVVAKN 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831  87 HAESTYGLYRTHLLSRLPIPDSQVITINPQLPVEEAAEDYAKKLRQAFQGDSI--------PVFDLLILGVGPDGHTCSL 158
Cdd:PLN02360   88 HADSNYKLAKDGLLSKVPVVPSHVYSINDTVTAEEAATDYEFAIRQLVKTRTIgvsdisdcPKFDLILLGMGSDGHVASL 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831 159 FPNHPLLQEREKIVAPISDSPKPPPHRVTLTLPVLNAARTVIFVATGESKAAVLKRILEDKEENP----LPATLVQPHTG 234
Cdd:PLN02360  168 FPNHPALEEKDDWVTFITDSPKPPPERITFTLPVINSASNVAVVATGESKANAVHLAIDDVTEGPdapsLPARMVQPTKG 247

                         250
                  ....*....|....
gi 1926336831 235 KLCWFLDEAAARLL 248
Cdd:PLN02360  248 KLVWFLDKPAASKL 261
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 9-249 8.26e-66

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 204.62  E-value: 8.26e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831   9 ISVFSSPQELGASLAQLVAQRAACCLAgARARFALGLSGGS--------LVSMLARDLPAAAapagpaslaRWTVGFCDE 80
Cdd:COG0363     4 VIIFPDAEELAAAAAERAAERIAEAIA-EKGRAVLGLAGGStplglyeeLARLHKEGGLDWS---------RVHVFNLDE 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831  81 RL-VPFEHAESTYGLYRTHLLSRLPIPDSQVITINPQLP-VEEAAEDYAKKLRQAfqgdsiPVFDLLILGVGPDGHTCSL 158
Cdd:COG0363    74 YVgLPPDHPQSNRRFMREALLDHVDIPPENIHIPDGEAEdPEAAAARYEALIAEA------GGIDLQLLGIGEDGHIAFN 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831 159 FPNHPLLQEREKIVAP-----------ISDSPKPPPHRVTLTLPVLNAARTVIFVATGESKAAVLKRILEDKEENPLPAT 227
Cdd:COG0363   148 FPGSPFLSETDRVVTLdestrqanarfFGSIPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPAS 227

                         250       260
                  ....*....|....*....|..
gi 1926336831 228 LVQPHtGKLCWFLDEAAARLLT 249
Cdd:COG0363   228 ILQGH-PNVTWFLDEAAASLLT 248
 
Name Accession Description Interval E-value
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 11-248 4.30e-95

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 278.87  E-value: 4.30e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831  11 VFSSPQELGASLAQLVAQRAACCLAgARARFALGLSGGSLVSMLARDLPAAAAPAGpaslaRWTVGFCDERLVPFEHAES 90
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALA-ERGQFSLALSGGRSPIALLEALAAQPLDWS-----RIHLFLGDERYVPLDHADS 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831  91 TYGLYRTHLLSRLPIPDSQVITINPQLP-VEEAAEDYAKKLRQAFQGDSIPVFDLLILGVGPDGHTCSLFPNHPLLQERE 169
Cdd:TIGR01198  75 NTGLAREALLDRVAIPASNIHPMPTELSdIEEAAELYEQELAAAFQPIVFPVFDLLLLGMGPDGHTASLFPHTPALQETE 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1926336831 170 KIVAPISDSPKPPPHRVTLTLPVLNAARTVIFVATGESKAAVLKRILEDKEENPLPATLVQPHTGKLCWFLDEAAARLL 248
Cdd:TIGR01198 155 RLVTVLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYPLPAAGVLHSGKTLWLLDYAAARKL 233
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 16-240 2.48e-90

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 265.96  E-value: 2.48e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831  16 QELGASLAQLVAQRAACCLAgARARFALGLSGGSLVSMLARDLPAAAAPAGPaslaRWTVGFCDERLVPFEHAESTYGLY 95
Cdd:cd01400     1 EALAEALADRIAEALAAAIA-KRGRFSLALSGGSTPKPLYELLAAAPALDWS----KVHVFLGDERCVPPDDPDSNYRLA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831  96 RTHLLSRLPIPDSQVITINPQLPVEEAAEDYAKKLRQAFqgDSIPVFDLLILGVGPDGHTCSLFPNHP-LLQEREKIVAP 174
Cdd:cd01400    76 REALLSHVAIPAANIHPIPTELGPEDAAAAYEKELRALF--GGVPPFDLVLLGMGPDGHTASLFPGHPaLLEETDRLVVA 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1926336831 175 ISDSPKPPPHRVTLTLPVLNAARTVIFVATGESKAAVLKRILEDKEENPLPATLVQPHTGKLCWFL 240
Cdd:cd01400   154 VTDSPKPPPERITLTLPVLNNARRVVFLVTGAEKAEALKRALAGPDPEELPAARVLPRPGEVLWFL 219
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
13-238 1.88e-89

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 264.10  E-value: 1.88e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831  13 SSPQELGASLAQLVAQRAACCLAgARARFALGLSGGSLVSMLARDLPAAAAPAGPAslaRWTVGFCDERLVPFEHAESTY 92
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAALA-ERGRFTLALSGGSTPKPLYELLAAAPARLDWS---RVHVFWGDERCVPPDDPDSNY 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831  93 GLYRTHLLSRLPIPDSQVITIN-PQLPVEEAAEDYAKKLRQAFQGDSIPVFDLLILGVGPDGHTCSLFPNHPLLQEREKI 171
Cdd:pfam01182  77 GMAREALLSHVPIPASNVHPIPaSAADPEEAAAAYEAELRELLPDLELPVFDLVLLGMGPDGHTASLFPGSPALEETDRL 156

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1926336831 172 VAPISDSPKPPPHRVTLTLPVLNAARTVIFVATGESKAAVLKRILEDkEENPLPATLVQPHTGKLCW 238
Cdd:pfam01182 157 VVAVTDSPKPPPERITLTLPVLNAARRVWFLVTGAGKADALRRALAG-DPDPLPAALVRPGAGETVW 222
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 7-248 3.46e-68

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 211.64  E-value: 3.46e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831   7 CLISVFSSPQELGASLAQLVAQRAACCLAgARARFALGLSGGSLVSMLARDLPAAAAPAGPASlaRWTVGFCDERLVPFE 86
Cdd:PLN02360   11 GEIRVHENLDELSTDLAEYIAELSEASVK-ERGVFAIALSGGSLISFMGKLCEAPYNKTVDWA--KWYIFWADERVVAKN 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831  87 HAESTYGLYRTHLLSRLPIPDSQVITINPQLPVEEAAEDYAKKLRQAFQGDSI--------PVFDLLILGVGPDGHTCSL 158
Cdd:PLN02360   88 HADSNYKLAKDGLLSKVPVVPSHVYSINDTVTAEEAATDYEFAIRQLVKTRTIgvsdisdcPKFDLILLGMGSDGHVASL 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831 159 FPNHPLLQEREKIVAPISDSPKPPPHRVTLTLPVLNAARTVIFVATGESKAAVLKRILEDKEENP----LPATLVQPHTG 234
Cdd:PLN02360  168 FPNHPALEEKDDWVTFITDSPKPPPERITFTLPVINSASNVAVVATGESKANAVHLAIDDVTEGPdapsLPARMVQPTKG 247

                         250
                  ....*....|....
gi 1926336831 235 KLCWFLDEAAARLL 248
Cdd:PLN02360  248 KLVWFLDKPAASKL 261
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 9-249 8.26e-66

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 204.62  E-value: 8.26e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831   9 ISVFSSPQELGASLAQLVAQRAACCLAgARARFALGLSGGS--------LVSMLARDLPAAAapagpaslaRWTVGFCDE 80
Cdd:COG0363     4 VIIFPDAEELAAAAAERAAERIAEAIA-EKGRAVLGLAGGStplglyeeLARLHKEGGLDWS---------RVHVFNLDE 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831  81 RL-VPFEHAESTYGLYRTHLLSRLPIPDSQVITINPQLP-VEEAAEDYAKKLRQAfqgdsiPVFDLLILGVGPDGHTCSL 158
Cdd:COG0363    74 YVgLPPDHPQSNRRFMREALLDHVDIPPENIHIPDGEAEdPEAAAARYEALIAEA------GGIDLQLLGIGEDGHIAFN 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831 159 FPNHPLLQEREKIVAP-----------ISDSPKPPPHRVTLTLPVLNAARTVIFVATGESKAAVLKRILEDKEENPLPAT 227
Cdd:COG0363   148 FPGSPFLSETDRVVTLdestrqanarfFGSIPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPAS 227

                         250       260
                  ....*....|....*....|..
gi 1926336831 228 LVQPHtGKLCWFLDEAAARLLT 249
Cdd:COG0363   228 ILQGH-PNVTWFLDEAAASLLT 248
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 86-248 7.33e-21

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 87.93  E-value: 7.33e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831  86 EHAESTYGLYRTHLLSRLPIPDSQVITINPQLP-VEEAAEDYAKKLRQAfqgDSIpvfDLLILGVGPDGHTCslF--PNH 162
Cdd:cd01399    66 DHPQSYHYFMRENLFDHIDIKPENIHIPDGNAAdLEAECRRYEALIAEA---GGI---DLQLLGIGENGHIG--FnePGS 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831 163 PL--------LQEREKIV-APISDSPKPPPHR-VTLTLPVLNAARTVIFVATGESKAAVLKRILEDKEENPLPATLVQPH 232
Cdd:cd01399   138 SLdsrtrvvtLDESTRQAnARFFDGDEDVPTQaITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLH 217

                         170
                  ....*....|....*.
gi 1926336831 233 TgKLCWFLDEAAARLL 248
Cdd:cd01399   218 P-NVTVILDEAAASEL 232
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 9-250 8.49e-16

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 74.48  E-value: 8.49e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831   9 ISVFSSPQELGASLAQLVAQRAACCLAGARARFALGLSGGS--------LVSMLARDLPAaaapagpaslarWT--VGF- 77
Cdd:PRK00443    3 LIILKTAEEVGKWAARHIANRINAFLPTKERPFVLGLATGSspletykaLIELHKAGKVD------------FSrvTTFn 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831  78 CDERL-VPFEHAESTYGLYRTHLLSRLPIPDSQVITINPQLP-VEEAAEDYAKKLRQAFqgdsiPVfDLLILGVGPDGH- 154
Cdd:PRK00443   71 LDEYVgLPADHPESYRYFMRENFFDHVDIPPENINLLNGNAPdPEAECRRYEEKIKSAG-----GI-DLQILGIGENGHi 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831 155 -----TCSLfpNHP----LLQEREKIV------APISDSPKpppHRVTLTLPVLNAARTVIFVATGESKAAVLKRILEDK 219
Cdd:PRK00443  145 afnepGSSF--ASRtrikTLTEDTRIAnsrffdGDIEQVPK---YALTVGVGTILDAKEIMLLAPGHNKAEAVKAAVEGP 219

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1926336831 220 EENPLPATLVQPHTgKLCWFLDEAAARLLTV 250
Cdd:PRK00443  220 VNHMWPASILQLHP-KATLVLDEAAASELKV 249
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
 84-250 2.96e-12

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 64.78  E-value: 2.96e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831  84 PFEHAESTYGLYRTHLLSRLPIPDSQVITINPQLP-VEEAAEDYAKKLRqafqgdSIPVFDLLILGVGPDGHTCSLFPNH 162
Cdd:PTZ00285   78 PRDHPQSYHYFMKENFFDHVDIKEENRHILNGTAPdLEEECRRYEEKIR------AVGGIDLFLAGIGTDGHIAFNEPGS 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831 163 PLLQE-------REKIVAPI----SDSPKPPPHRVTLTLPVLNAARTVIFVATGESKAAVLKRILEDKEENPLPATLVQP 231
Cdd:PTZ00285  152 SLDSRtrvkslnQETIDANArffgNDISKVPTMALTVGIRTIMEAREVLLLATGASKAIAVARCVEGGVTHMCPASALQM 231

                         170
                  ....*....|....*....
gi 1926336831 232 HTgKLCWFLDEAAARLLTV 250
Cdd:PTZ00285  232 HP-AAVLCLDEDATLELKV 249
PRK12358 PRK12358
glucosamine-6-phosphate deaminase;
79-248 1.06e-11

glucosamine-6-phosphate deaminase;


Pssm-ID: 183470  Cd Length: 239  Bit Score: 62.85  E-value: 1.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831  79 DErlVPFEHAES---TYGLYRTHLLSRLPIPDSQVITINpqlpveeaAEDYAKKLRQAFQGDSIpvfDLLILGVGPDGHT 155
Cdd:PRK12358   66 DE--IPFRGKEGegvTITNLRNLFFTPAGIKEENIHKLT--------IDNYREHDQKLARDGGL---DLVVLGLGADGHF 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831 156 CSLFPNH----------PLLQEREKIVAPI---SDSPKPPPHRVTLTLPVLNAARTVIFVATGESKAAVLKRILEDKEEN 222
Cdd:PRK12358  133 CGNLPGTthfhdetvevPIQGEMVDIVAHGelgGDFSLVPDSYVTMGPKSIMAAKNLLLIVNGKGKAQILKKVLQGPVTE 212

                         170       180
                  ....*....|....*....|....*.
gi 1926336831 223 PLPATLVQPHTgKLCWFLDEAAARLL 248
Cdd:PRK12358  213 DVPASILQLHP-NLTVILDEAAAAEL 237
PRK02122 PRK02122
glucosamine-6-phosphate deaminase-like protein; Validated
 86-249 4.88e-10

glucosamine-6-phosphate deaminase-like protein; Validated


Pssm-ID: 235005 [Multi-domain]  Cd Length: 652  Bit Score: 59.27  E-value: 4.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831  86 EHAESTYGLYRTHLLSRLPIPDSQVITINPQLPVEEAAE---DYAKKLRQAfqGDsipvFDLLILGVGPDGHtcsLFPNH 162
Cdd:PRK02122  106 DSLQSYHRFMKENLFDHVDIPPENIHIPDGTIPKEEIDEycrDYEEKIEAA--GG----IDFQLLGIGRTGH---IGFNE 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831 163 P--LLQEREKIVA--PIS---------DSPKPPPHRVTLTLPVLNAARTVIFVATGESKAAVLKRILEDKEENPLPATLV 229
Cdd:PRK02122  177 PgsGRNSRTRLVTldHITrrdaasdffGEENVPRKAITMGVGTILKARRIVLLAWGEHKAPIIKRAVEGEISDEVPASYL 256

                         170       180
                  ....*....|....*....|
gi 1926336831 230 QPHTgKLCWFLDEAAARLLT 249
Cdd:PRK02122  257 QEHP-NATFVLDLAAASELT 275
PRK09762 PRK09762
galactosamine-6-phosphate isomerase; Provisional
 83-237 9.09e-08

galactosamine-6-phosphate isomerase; Provisional


Pssm-ID: 182064  Cd Length: 232  Bit Score: 51.37  E-value: 9.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831  83 VPFEHAESTYGLYRTHLLSRLPIPDSQVITINPQlpveeaAEDYAKKLRQAFQGDSIPVFDLLILGVGPDGH------TC 156
Cdd:PRK09762   72 LPLTMPGTCETFLQQHIVQPLGLREDQLISFRSE------EINETECERVTNLIARKGGLDLCVLGLGKNGHlglnepGE 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831 157 SLFPNHPL--LQEREKIVAPISDSPKPPPHRVTLTLPVLNAARTVIFVATGESKAAVLKRILEDKEENPLPATLVQPHTG 234
Cdd:PRK09762  146 SLQPACHIsqLDARTQQHEMLKTAGRPVTRGITLGLKDILNAREVLLLVTGEGKQDATERFLTAKVSTAIPASFLWLHSN 225


                  ...
gi 1926336831 235 KLC 237
Cdd:PRK09762  226 FIC 228
SugarP_isomerase cd00458
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
 75-173 8.35e-06

SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.


Pssm-ID: 238258  Cd Length: 169  Bit Score: 45.04  E-value: 8.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1926336831  75 VGF-CDERLVPFEHAESTYGLYRTHLLSRLPIPDSQVITINPQLPVEEAAEDYAKKLRqafqgDSIPVFDLLILGVGPDG 153
Cdd:cd00458    52 VGFpTDERYVPLDSDQSNFRQAKLLAFEHDIIPASNVHYVDTSLPIEKACEKYEREIL-----DQVDAIDLAVDGAGYRA 126

                          90       100
                  ....*....|....*....|
gi 1926336831 154 HTCSLfpnhpLLQEREKIVA 173
Cdd:cd00458   127 GTVIV-----LVDGRKKVDY 141
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH