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Conserved domains on  [gi|1919279743|ref|WP_193353686|]
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peptide chain release factor 2 [Chlamydia trachomatis]

Protein Classification

PCRF domain-containing protein( domain architecture ID 1750053)

peptide chain release factor (PCRF) domain-containing protein similar to Homo sapiens mitochondrial peptide chain release factor 1 (MTRF1), MTRF1-like and 28S mitochondrial ribosomal protein S35 (MRPS35)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PCRF super family cl40670
This domain is found in peptide chain release factors;
8-362 7.70e-168

This domain is found in peptide chain release factors;


The actual alignment was detected with superfamily member TIGR00020:

Pssm-ID: 477417 [Multi-domain]  Cd Length: 364  Bit Score: 472.72  E-value: 7.70e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743   8 RLEVLLEGLALTRRSLfDPEGKENELKELEQQAVQDGFWDDVARAGKISERIARLKQQLSEFNELKNKVSTIQFFLEDEE 87
Cdd:TIGR00020   8 RIEDLTSRLDTVRGSL-DPEKKKARLEELEKEMEDPNFWNDQERAQAVIKERSSLEAVLDTLEELKNSLEDLSELLELAV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743  88 SSKDLEMQKELEKEFVFCEKKITEWETLRLLSGELDRNSCFLSINAGAGGTESCDWVEMVLRMYMRWASSHSWRVEVIDR 167
Cdd:TIGR00020  87 EEDDEETFNELDAELKALEKKLAELELRTMLSGEYDANNAYLTIQAGAGGTEAQDWASMLYRMYLRWAERRGFKVEIIDY 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 168 LDGEVAGIKHITLKLVGEYAYGYAKAESGVHRLVRISPFDSNAKRHTSFASVEVFPEIDDKIEVEIRPGDIRIDTYRSSG 247
Cdd:TIGR00020 167 SEGEEAGIKSVTILIKGPYAYGYLKSEQGVHRLVRISPFDANGRRHTSFASVFVMPEVDDDIDIEIKPEDLRIDTYRASG 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 248 AGGQHVNVTDSAVRITHFPTGIVVSCQNERSQIQNREACMNMLRARIYQKLLQERLEKQNIDRKNKKEISWGSQIRNYVF 327
Cdd:TIGR00020 247 AGGQHVNKTDSAVRITHIPTGIVVQCQNDRSQHKNKDSAMKVLKAKLYELEMEKEQAEKDAKEGEKSEIGWGSQIRSYVL 326

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1919279743 328 QPYTLVKDVRTGYEVGNIQAMMDGElLDAFIKAYL 362
Cdd:TIGR00020 327 HPYSMVKDLRTGYETGNVQAVLDGD-IDQFIEAYL 360
 
Name Accession Description Interval E-value
prfB TIGR00020
peptide chain release factor 2; In many but not all taxa, there is a conserved real ...
 8-362 7.70e-168

peptide chain release factor 2; In many but not all taxa, there is a conserved real translational frameshift at a TGA codon. RF-2 helps terminate translation at TGA codons and can therefore regulate its own production by readthrough when RF-2 is insufficient. There is a Pfam model called "RF-1" for the superfamily of RF-1, RF-2, mitochondrial, RF-H, etc. [Protein synthesis, Translation factors]


Pssm-ID: 272858 [Multi-domain]  Cd Length: 364  Bit Score: 472.72  E-value: 7.70e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743   8 RLEVLLEGLALTRRSLfDPEGKENELKELEQQAVQDGFWDDVARAGKISERIARLKQQLSEFNELKNKVSTIQFFLEDEE 87
Cdd:TIGR00020   8 RIEDLTSRLDTVRGSL-DPEKKKARLEELEKEMEDPNFWNDQERAQAVIKERSSLEAVLDTLEELKNSLEDLSELLELAV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743  88 SSKDLEMQKELEKEFVFCEKKITEWETLRLLSGELDRNSCFLSINAGAGGTESCDWVEMVLRMYMRWASSHSWRVEVIDR 167
Cdd:TIGR00020  87 EEDDEETFNELDAELKALEKKLAELELRTMLSGEYDANNAYLTIQAGAGGTEAQDWASMLYRMYLRWAERRGFKVEIIDY 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 168 LDGEVAGIKHITLKLVGEYAYGYAKAESGVHRLVRISPFDSNAKRHTSFASVEVFPEIDDKIEVEIRPGDIRIDTYRSSG 247
Cdd:TIGR00020 167 SEGEEAGIKSVTILIKGPYAYGYLKSEQGVHRLVRISPFDANGRRHTSFASVFVMPEVDDDIDIEIKPEDLRIDTYRASG 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 248 AGGQHVNVTDSAVRITHFPTGIVVSCQNERSQIQNREACMNMLRARIYQKLLQERLEKQNIDRKNKKEISWGSQIRNYVF 327
Cdd:TIGR00020 247 AGGQHVNKTDSAVRITHIPTGIVVQCQNDRSQHKNKDSAMKVLKAKLYELEMEKEQAEKDAKEGEKSEIGWGSQIRSYVL 326

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1919279743 328 QPYTLVKDVRTGYEVGNIQAMMDGElLDAFIKAYL 362
Cdd:TIGR00020 327 HPYSMVKDLRTGYETGNVQAVLDGD-IDQFIEAYL 360
PRK05589 PRK05589
peptide chain release factor 2; Provisional
 42-362 4.18e-135

peptide chain release factor 2; Provisional


Pssm-ID: 235520 [Multi-domain]  Cd Length: 325  Bit Score: 388.39  E-value: 4.18e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743  42 QDGFWDDVARAGKISERIARLKQQLSEFNELKNKVSTIQFFLEDEESSKDlEMQKELEKEFVFCEKKITEWETLRLLSGE 121
Cdd:PRK05589    3 EPNFWNDIKEAQEITSEEKYLKDKLDKYNHLRNRIEDIEVLCEMMSEEDD-EMKKEIISEVKNIKEEIDRFKIETLLSGE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 122 LDRNSCFLSINAGAGGTESCDWVEMVLRMYMRWASSHSWRVEVIDRLDGEVAGIKHITLKLVGEYAYGYAKAESGVHRLV 201
Cdd:PRK05589   82 YDRNNAILTLHSGVGGTDAQDWTEMLLRMYTRWAEKKGYKVEIIDLLEGDEAGIKSVTLKITGEFAYGYLKAEKGIHRLV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 202 RISPFDSNAKRHTSFASVEVFPEIDDKIEVEIRPGDIRIDTYRSSGAGGQHVNVTDSAVRITHFPTGIVVSCQNERSQIQ 281
Cdd:PRK05589  162 RISPFNANGKRQTSFASVEVLPELTDDQDIEIRSEDLKIDTYRAGGAGGQHVNKTESAVRITHIPTGIVVQCQNERSQHS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 282 NREACMNMLRARIYQklLQERLEKQNID--RKNKKEISWGSQIRNYVFQPYTLVKDVRTGYEVGNIQAMMDGElLDAFIK 359
Cdd:PRK05589  242 NKETAMKMLKSKLVE--LKERAHKEKIEdlTGELKDMGWGSQIRSYVFHPYNLVKDHRTGVETSNVDSVMDGD-IDNFIT 318


                  ...
gi 1919279743 360 AYL 362
Cdd:PRK05589  319 QYL 321
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 27-360 2.40e-91

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 278.04  E-value: 2.40e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743  27 EGKENELKELEQQAVQDGFWDDVARAGKISERIARLKQQLSEFNELKNKVSTIQFFLEDEESSKDLEMQKELEKEFVFCE 106
Cdd:COG0216     7 EALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEESDPEMREMAKEELEELE 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 107 KKITEWET-LRLL---SGELDRNSCFLSINAGAGGTESCDWVEMVLRMYMRWASSHSWRVEVIDRLDGEVAGIKHITLKL 182
Cdd:COG0216    87 ARLEELEEeLKILllpKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYKEVIFRI 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 183 VGEYAYGYAKAESGVHRLVRISPFDSNAKRHTSFASVEVFPEIDDkIEVEIRPGDIRIDTYRSSGAGGQHVNVTDSAVRI 262
Cdd:COG0216   167 SGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEE-VDVEINPKDLRIDTFRSSGAGGQHVNTTDSAVRI 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 263 THFPTGIVVSCQNERSQIQNREACMNMLRARIYQKLLQERLEKQNIDRKNKkeISWG--SQ-IRNYVFqPYTLVKDVRTG 339
Cdd:COG0216   246 THLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQ--VGSGdrSErIRTYNF-PQGRVTDHRIN 322

                         330       340
                  ....*....|....*....|.
gi 1919279743 340 YEVGNIQAMMDGElLDAFIKA 360
Cdd:COG0216   323 LTLYKLDEVMEGD-LDELIDA 342
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 29-219 4.27e-73

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 225.34  E-value: 4.27e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743  29 KENELKELEQQAVQDGFWDDVARAGKISERIARLKQQLSEFNELKNKVSTIQfflEDEESSKDLEMQKELEKEFVFCEKK 108
Cdd:pfam03462   1 LEERYEELEALLSDPDVWDDQKRAQKLSKEYSELEPIVEAYREYKQALEDLE---EAKELLEDPELAELAEEELEELEKR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 109 ITEWET--LRLLS--GELDRNSCFLSINAGAGGTESCDWVEMVLRMYMRWASSHSWRVEVIDRLDGEVAGIKHITLKLVG 184
Cdd:pfam03462  78 LEELEEelKLLLLpkDPNDDKNAILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEATFEISG 157

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1919279743 185 EYAYGYAKAESGVHRLVRISPFDSNAKRHTSFASV 219
Cdd:pfam03462 158 EGAYGRLKFESGVHRVQRVPPTESQGRIHTSFATV 192
PCRF smart00937
This domain is found in peptide chain release factors;
83-194 6.24e-41

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 139.91  E-value: 6.24e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743   83 LEDEESSKDLEMQKELEKEFV-FCEKKITEWETLRLLSG-ELDRNSCFLSINAGAGGTESCDWVEMVLRMYMRWASSHSW 160
Cdd:smart00937   3 LEEEEDDEMRELAEEELEELEaELEEELEELLKLLLLPKdPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAERKGW 82

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1919279743  161 RVEVIDRLDGEVAGIKHITLKLVGEYAYGYAKAE 194
Cdd:smart00937  83 KVEVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
 
Name Accession Description Interval E-value
prfB TIGR00020
peptide chain release factor 2; In many but not all taxa, there is a conserved real ...
 8-362 7.70e-168

peptide chain release factor 2; In many but not all taxa, there is a conserved real translational frameshift at a TGA codon. RF-2 helps terminate translation at TGA codons and can therefore regulate its own production by readthrough when RF-2 is insufficient. There is a Pfam model called "RF-1" for the superfamily of RF-1, RF-2, mitochondrial, RF-H, etc. [Protein synthesis, Translation factors]


Pssm-ID: 272858 [Multi-domain]  Cd Length: 364  Bit Score: 472.72  E-value: 7.70e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743   8 RLEVLLEGLALTRRSLfDPEGKENELKELEQQAVQDGFWDDVARAGKISERIARLKQQLSEFNELKNKVSTIQFFLEDEE 87
Cdd:TIGR00020   8 RIEDLTSRLDTVRGSL-DPEKKKARLEELEKEMEDPNFWNDQERAQAVIKERSSLEAVLDTLEELKNSLEDLSELLELAV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743  88 SSKDLEMQKELEKEFVFCEKKITEWETLRLLSGELDRNSCFLSINAGAGGTESCDWVEMVLRMYMRWASSHSWRVEVIDR 167
Cdd:TIGR00020  87 EEDDEETFNELDAELKALEKKLAELELRTMLSGEYDANNAYLTIQAGAGGTEAQDWASMLYRMYLRWAERRGFKVEIIDY 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 168 LDGEVAGIKHITLKLVGEYAYGYAKAESGVHRLVRISPFDSNAKRHTSFASVEVFPEIDDKIEVEIRPGDIRIDTYRSSG 247
Cdd:TIGR00020 167 SEGEEAGIKSVTILIKGPYAYGYLKSEQGVHRLVRISPFDANGRRHTSFASVFVMPEVDDDIDIEIKPEDLRIDTYRASG 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 248 AGGQHVNVTDSAVRITHFPTGIVVSCQNERSQIQNREACMNMLRARIYQKLLQERLEKQNIDRKNKKEISWGSQIRNYVF 327
Cdd:TIGR00020 247 AGGQHVNKTDSAVRITHIPTGIVVQCQNDRSQHKNKDSAMKVLKAKLYELEMEKEQAEKDAKEGEKSEIGWGSQIRSYVL 326

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1919279743 328 QPYTLVKDVRTGYEVGNIQAMMDGElLDAFIKAYL 362
Cdd:TIGR00020 327 HPYSMVKDLRTGYETGNVQAVLDGD-IDQFIEAYL 360
PRK05589 PRK05589
peptide chain release factor 2; Provisional
 42-362 4.18e-135

peptide chain release factor 2; Provisional


Pssm-ID: 235520 [Multi-domain]  Cd Length: 325  Bit Score: 388.39  E-value: 4.18e-135
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743  42 QDGFWDDVARAGKISERIARLKQQLSEFNELKNKVSTIQFFLEDEESSKDlEMQKELEKEFVFCEKKITEWETLRLLSGE 121
Cdd:PRK05589    3 EPNFWNDIKEAQEITSEEKYLKDKLDKYNHLRNRIEDIEVLCEMMSEEDD-EMKKEIISEVKNIKEEIDRFKIETLLSGE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 122 LDRNSCFLSINAGAGGTESCDWVEMVLRMYMRWASSHSWRVEVIDRLDGEVAGIKHITLKLVGEYAYGYAKAESGVHRLV 201
Cdd:PRK05589   82 YDRNNAILTLHSGVGGTDAQDWTEMLLRMYTRWAEKKGYKVEIIDLLEGDEAGIKSVTLKITGEFAYGYLKAEKGIHRLV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 202 RISPFDSNAKRHTSFASVEVFPEIDDKIEVEIRPGDIRIDTYRSSGAGGQHVNVTDSAVRITHFPTGIVVSCQNERSQIQ 281
Cdd:PRK05589  162 RISPFNANGKRQTSFASVEVLPELTDDQDIEIRSEDLKIDTYRAGGAGGQHVNKTESAVRITHIPTGIVVQCQNERSQHS 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 282 NREACMNMLRARIYQklLQERLEKQNID--RKNKKEISWGSQIRNYVFQPYTLVKDVRTGYEVGNIQAMMDGElLDAFIK 359
Cdd:PRK05589  242 NKETAMKMLKSKLVE--LKERAHKEKIEdlTGELKDMGWGSQIRSYVFHPYNLVKDHRTGVETSNVDSVMDGD-IDNFIT 318


                  ...
gi 1919279743 360 AYL 362
Cdd:PRK05589  319 QYL 321
PRK07342 PRK07342
peptide chain release factor 2; Provisional
 38-362 1.75e-124

peptide chain release factor 2; Provisional


Pssm-ID: 235997 [Multi-domain]  Cd Length: 339  Bit Score: 361.89  E-value: 1.75e-124
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743  38 QQAVQDGFWDDVARAGKISERIARLKQQLSEFNELKNKVSTIQFFLEDEESSKDLEMQKELEKEFVFCEKKITEWETLRL 117
Cdd:PRK07342    1 NKAEDPSLWNDAQEAQKLMRERQQLDDSINGINHLEQTLNDNIELIAMGEEEGDKSIVEDAEKTIRDLKDEIDRRQIDAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 118 LSGELDRNSCFLSINAGAGGTESCDWVEMVLRMYMRWASSHSWRVEVIDRLDGEVAGIKHITLKLVGEYAYGYAKAESGV 197
Cdd:PRK07342   81 LSGEADANDTYLEVHAGAGGTESQDWASMLLRMYTRWAERQGRKVEVLEVHDGEEAGIKSATILVKGHNAYGWLKTESGV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 198 HRLVRISPFDSNAKRHTSFASVEVFPEIDDKIEVEIRPGDIRIDTYRSSGAGGQHVNVTDSAVRITHFPTGIVVSCQNER 277
Cdd:PRK07342  161 HRLVRISPYDSNARRHTSFASIWVYPVIDDNIEVDVNESDVRIDTYRSSGAGGQHVNTTDSAVRITHIPTGIVVQCQQER 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 278 SQIQNREACMNMLRARIYQKLLQERLEKQNIDRKNKKEISWGSQIRNYVFQPYTLVKDVRTGYEVGNIQAMMDGElLDAF 357
Cdd:PRK07342  241 SQHKNRAKAWSMLRARLYEEELKKREEATNAAAASKTDIGWGHQIRSYVLQPYQLVKDLRTGVESTNPQDVLDGD-LNEF 319


                  ....*
gi 1919279743 358 IKAYL 362
Cdd:PRK07342  320 MEAAL 324
PRK06746 PRK06746
peptide chain release factor 2; Provisional
 44-362 9.74e-116

peptide chain release factor 2; Provisional


Pssm-ID: 75726 [Multi-domain]  Cd Length: 326  Bit Score: 339.40  E-value: 9.74e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743  44 GFWDDVARAGKISERIARLKQQLSEFNELKNKVSTIQFFLEDEESSKDLEMQKELEKEFVFCEKKITEWETLRLLSGELD 123
Cdd:PRK06746    5 GFWDDQQGAQAVINEANALKDMVGKFRQLDETFENLEITHELLKEEYDEDLHEELESEVKGLIQEMNEYELQLLLSDPYD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 124 RNSCFLSINAGAGGTESCDWVEMVLRMYMRWASSHSWRVEVIDRLDGEVAGIKHITLKLVGEYAYGYAKAESGVHRLVRI 203
Cdd:PRK06746   85 KNNAILELHPGAGGTESQDWGSMLLRMYTRWAEKRGFKVETVDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRI 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 204 SPFDSNAKRHTSFASVEVFPEIDDKIEVEIRPGDIRIDTYRSSGAGGQHVNVTDSAVRITHFPTGIVVSCQNERSQIQNR 283
Cdd:PRK06746  165 SPFDSSGRRHTSFVSCEVVPEFNDEVEIEVRTEDLKIDTYRASGAGGQHVNTTDSAVRITHTPTNTVVTCQSERSQIKNR 244

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1919279743 284 EACMNMLRARIYQKLLQERLEKQNIDRKNKKEISWGSQIRNYVFQPYTLVKDVRTGYEVGNIQAMMDGElLDAFIKAYL 362
Cdd:PRK06746  245 EHAMKMLKAKLYQKKLEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSLVKDHRTNTEVGNVQAVMDGE-IDPFIDAYL 322
PRK08787 PRK08787
peptide chain release factor 2; Provisional
 82-362 1.21e-112

peptide chain release factor 2; Provisional


Pssm-ID: 136970 [Multi-domain]  Cd Length: 313  Bit Score: 330.85  E-value: 1.21e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743  82 FLEDEESSKDLEMQKELEKEFVFCEKKITEWETLRLLSGELDRNSCFLSINAGAGGTESCDWVEMVLRMYMRWASSHSWR 161
Cdd:PRK08787   22 LLDLAESEQDEDTALAVIADLDKYQAHVEKLEFQRMFSGQMDGANAFVDIQAGAGGTEAQDWAEILLRMYLRWAESRGWK 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 162 VEVIDRLDGEVAGIKHITLKLVGEYAYGYAKAESGVHRLVRISPFDSNAKRHTSFASVEVFPEIDDKIEVEIRPGDIRID 241
Cdd:PRK08787  102 TELMEVSGGEVAGIKSATVRIEGEYAYGWLKTEIGVHRLVRKSPFDSDNRRHTSFTSVFVSPEVDDNIEIDINPADLRTD 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 242 TYRSSGAGGQHVNVTDSAVRITHFPTGIVVSCQNERSQIQNREACMNMLRARIYQKLLQERLEKQNIDRKNKKEISWGSQ 321
Cdd:PRK08787  182 VYRSSGAGGQHVNKTESAVRITHIPTNTVVACQTGRSQHQNRDNAMKMLAAKLYELEVQKRNAEKDALEATKSDIGWGSQ 261

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1919279743 322 IRNYVFQPyTLVKDVRTGYEVGNIQAMMDGElLDAFIKAYL 362
Cdd:PRK08787  262 IRNYVLDQ-SRIKDLRTGIERSDTQKVLDGD-LDEFVEASL 300
prfA PRK00591
peptide chain release factor 1; Validated
 30-360 1.82e-95

peptide chain release factor 1; Validated


Pssm-ID: 234801 [Multi-domain]  Cd Length: 359  Bit Score: 288.52  E-value: 1.82e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743  30 ENELKELEQQAVQDGFWDDVARAGKISERIARLKQQLSEFNELKNKVSTIQfflEDEE---SSKDLEMQKELEKEFVFCE 106
Cdd:PRK00591   12 EERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKQAQEDLE---EAKEmleEESDPEMREMAKEELKELE 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 107 KKITEWET-LRLL---SGELDRNSCFLSINAGAGGTESCDWVEMVLRMYMRWASSHSWRVEVIDRLDGEVAGIKHITLKL 182
Cdd:PRK00591   89 ERLEELEEeLKILllpKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERQGWKVEILSASEGELGGYKEVIAEI 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 183 VGEYAYGYAKAESGVHRLVRISPFDSNAKRHTSFASVEVFPEIDDkIEVEIRPGDIRIDTYRSSGAGGQHVNVTDSAVRI 262
Cdd:PRK00591  169 SGDGVYSKLKFESGVHRVQRVPATESQGRIHTSAATVAVLPEAEE-VEVEINPKDLRIDTFRSSGAGGQHVNTTDSAVRI 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 263 THFPTGIVVSCQNERSQIQNREACMNMLRARIYQKLLQERLEKQNIDRKNKKeiswGS-----QIRNYVFqPYTLVKDVR 337
Cdd:PRK00591  248 THLPTGIVVECQDERSQHKNKAKAMKVLRARLYDAERQKAQAEEAATRKSQV----GSgdrseRIRTYNF-PQGRVTDHR 322

                         330       340
                  ....*....|....*....|...
gi 1919279743 338 TGYEVGNIQAMMDGElLDAFIKA 360
Cdd:PRK00591  323 INLTLYKLDEVMEGD-LDELIDA 344
PrfA COG0216
Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein ...
 27-360 2.40e-91

Protein chain release factor RF1 [Translation, ribosomal structure and biogenesis]; Protein chain release factor RF1 is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 439986 [Multi-domain]  Cd Length: 356  Bit Score: 278.04  E-value: 2.40e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743  27 EGKENELKELEQQAVQDGFWDDVARAGKISERIARLKQQLSEFNELKNKVSTIQFFLEDEESSKDLEMQKELEKEFVFCE 106
Cdd:COG0216     7 EALEERYEELEALLSDPEVISDQKRFRKLSKEYAELEPIVEAYREYKKLLEDIEEAKELLEEESDPEMREMAKEELEELE 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 107 KKITEWET-LRLL---SGELDRNSCFLSINAGAGGTESCDWVEMVLRMYMRWASSHSWRVEVIDRLDGEVAGIKHITLKL 182
Cdd:COG0216    87 ARLEELEEeLKILllpKDPNDDKNVILEIRAGTGGDEAALFAGDLFRMYSRYAERKGWKVEILSASEGELGGYKEVIFRI 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 183 VGEYAYGYAKAESGVHRLVRISPFDSNAKRHTSFASVEVFPEIDDkIEVEIRPGDIRIDTYRSSGAGGQHVNVTDSAVRI 262
Cdd:COG0216   167 SGEGVYSRLKFESGVHRVQRVPETESQGRIHTSAATVAVLPEAEE-VDVEINPKDLRIDTFRSSGAGGQHVNTTDSAVRI 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 263 THFPTGIVVSCQNERSQIQNREACMNMLRARIYQKLLQERLEKQNIDRKNKkeISWG--SQ-IRNYVFqPYTLVKDVRTG 339
Cdd:COG0216   246 THLPTGIVVECQDERSQHKNKAKAMKVLRARLYEAEQQKQQAEIAAERKSQ--VGSGdrSErIRTYNF-PQGRVTDHRIN 322

                         330       340
                  ....*....|....*....|.
gi 1919279743 340 YEVGNIQAMMDGElLDAFIKA 360
Cdd:COG0216   323 LTLYKLDEVMEGD-LDELIDA 342
PCRF pfam03462
PCRF domain; This domain is found in peptide chain release factors.
 29-219 4.27e-73

PCRF domain; This domain is found in peptide chain release factors.


Pssm-ID: 460929 [Multi-domain]  Cd Length: 192  Bit Score: 225.34  E-value: 4.27e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743  29 KENELKELEQQAVQDGFWDDVARAGKISERIARLKQQLSEFNELKNKVSTIQfflEDEESSKDLEMQKELEKEFVFCEKK 108
Cdd:pfam03462   1 LEERYEELEALLSDPDVWDDQKRAQKLSKEYSELEPIVEAYREYKQALEDLE---EAKELLEDPELAELAEEELEELEKR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 109 ITEWET--LRLLS--GELDRNSCFLSINAGAGGTESCDWVEMVLRMYMRWASSHSWRVEVIDRLDGEVAGIKHITLKLVG 184
Cdd:pfam03462  78 LEELEEelKLLLLpkDPNDDKNAILEIRAGAGGDEAALFAGDLFRMYTRYAERKGWKVEVLDYSETEAGGIKEATFEISG 157

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1919279743 185 EYAYGYAKAESGVHRLVRISPFDSNAKRHTSFASV 219
Cdd:pfam03462 158 EGAYGRLKFESGVHRVQRVPPTESQGRIHTSFATV 192
RF-1 pfam00472
RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and ...
 227-337 6.76e-63

RF-1 domain; This domain is found in peptide chain release factors such as RF-1 and RF-2, and a number of smaller proteins of unknown function. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.


Pssm-ID: 459823 [Multi-domain]  Cd Length: 111  Bit Score: 196.49  E-value: 6.76e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 227 DKIEVEIRPGDIRIDTYRSSGAGGQHVNVTDSAVRITHFPTGIVVSCQNERSQIQNREACMNMLRARIYQKLLQERLEKQ 306
Cdd:pfam00472   1 DEIEIEIDPKDLRIDTFRSSGAGGQHVNKTDSAVRLTHIPTGIVVKCQDERSQHQNREKALKRLRARLYELEEEKEEEKK 80

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1919279743 307 NIDRKNKKEISWGSQIRNYVFQPYTLVKDVR 337
Cdd:pfam00472  81 RRIKSQVGSGDRSEQIRTYNFKPQSRVKDHR 111
PrfB COG1186
Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein ...
 230-352 1.93e-45

Protein chain release factor PrfB [Translation, ribosomal structure and biogenesis]; Protein chain release factor PrfB is part of the Pathway/BioSystem: Translation factors


Pssm-ID: 440799 [Multi-domain]  Cd Length: 140  Bit Score: 152.59  E-value: 1.93e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 230 EVEIRPGDIRIDTYRSSGAGGQHVNVTDSAVRITHF------------PTGIVVSCQNERSQIQNREACMNMLRARIYQK 297
Cdd:COG1186    20 EIEIPESDLRIDTYRASGAGGQNVNKVSSAVRLTHDiassslpdsrltPGGIVVKAQEERSQHQNREDALKRLKALLYEA 99

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1919279743 298 LLQERLEK-QNIDRKNKKEISWGSQIRNyvfqpytLVKDVRtgyevGNIQammDGE 352
Cdd:COG1186   100 ELEPKERRaTKPTRGSKKRRLWGKQIRS-------MVKDLR-----GNVD---DGD 140
PCRF smart00937
This domain is found in peptide chain release factors;
83-194 6.24e-41

This domain is found in peptide chain release factors;


Pssm-ID: 214923 [Multi-domain]  Cd Length: 116  Bit Score: 139.91  E-value: 6.24e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743   83 LEDEESSKDLEMQKELEKEFV-FCEKKITEWETLRLLSG-ELDRNSCFLSINAGAGGTESCDWVEMVLRMYMRWASSHSW 160
Cdd:smart00937   3 LEEEEDDEMRELAEEELEELEaELEEELEELLKLLLLPKdPNDDKNAILEIRAGAGGDEAALFAGDLLRMYLRYAERKGW 82

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1919279743  161 RVEVIDRLDGEVAGIKHITLKLVGEYAYGYAKAE 194
Cdd:smart00937  83 KVEVLDESEGELGGIKEATLKISGEGAYGKLKFE 116
release_prfH TIGR03072
putative peptide chain release factor H; Members of this protein family are bacterial proteins ...
 128-310 6.61e-37

putative peptide chain release factor H; Members of this protein family are bacterial proteins homologous to peptide chain release factors 1 (RF-1, product of the prfA gene), and 2 (RF-2, product of the prfB gene). The member from Escherichia coli K-12, designated prfH, appears to be a pseudogene. This class I release factor is always found as the downstream gene of a two-gene operon. [Protein synthesis, Translation factors]


Pssm-ID: 213768  Cd Length: 200  Bit Score: 132.20  E-value: 6.61e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 128 FLSINAGAGGTESCDWVEMVLRMYMRWASSHSWRVEVIDRLDGEVAG-IKHITLKLVGEYAYGYAKAESGVHRLVRISPF 206
Cdd:TIGR03072   2 LLQLSSAQGPAECCLAVAKALERLTREAAARGVRVEVLEQEPGEVPGtLRSALVSLDGEAAAALADRWEGTLLWICPSPY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 207 DSNAKRHTSFASVEVFPEiddkiEVEIRPGDIRIDTYRSSGAGGQHVNVTDSAVRITHFPTGIVVSCQNERSQIQNReac 286
Cdd:TIGR03072  82 RPHHRRKNWFIGVQRFSA-----SEEATEDEIRFETLRSSGPGGQHVNKTESAVRATHLASGISVKVQSERSQHANK--- 153

                         170       180
                  ....*....|....*....|....
gi 1919279743 287 mnmlraRIYQKLLQERLEKQNIDR 310
Cdd:TIGR03072 154 ------RLATLLLAVRLADLQQEQ 171
PRK09256 PRK09256
aminoacyl-tRNA hydrolase;
231-323 1.54e-09

aminoacyl-tRNA hydrolase;


Pssm-ID: 181730 [Multi-domain]  Cd Length: 138  Bit Score: 55.54  E-value: 1.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919279743 231 VEIRPGDIRIDTYRSSGAGGQHVNVTDSAV-------------------------RIThfPTG-IVVSCQNERSQIQNRE 284
Cdd:PRK09256    8 LVIPENELEWRFIRASGPGGQNVNKVSTAVelrfdiaasslpefykerllalaghRIT--KDGvIVIKAQEFRSQERNRE 85

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1919279743 285 ACmnmlRARIyQKLLQERLEKQNIDRKNKkeISWGSQIR 323
Cdd:PRK09256   86 DA----LERL-VALIREALKPPKKRRATK--PTRGSKER 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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