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Conserved domains on  [gi|1919214028|gb|QOR14836|]
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glycosyltransferase family 2 protein [Haemophilus parainfluenzae]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 11421525)

glycosyltransferase family 2 protein catalyzes the transfer of saccharide moieties from a donor to an acceptor to form glycosidic bonds

CAZY:  GT2
EC:  2.4.-.-
Gene Ontology:  GO:0016757
PubMed:  16037492|18518825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-178 1.09e-30

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 114.41  E-value: 1.09e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   1 MFSIIVPSYNRKEEIPALLESLTKQTTYNFDVVIVDDCSK-EPVEVTQSYPFA---VKVIRNETNQGAAESRNIGVRNAD 76
Cdd:COG0463     3 LVSVVIPTYNEEEYLEEALESLLAQTYPDFEIIVVDDGSTdGTAEILRELAAKdprIRVIRLERNRGKGAARNAGLAAAR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028  77 NEWLLFLDDDDRFANDKCQKLADVIAEHPdVNFVYHPAKCEMVNEGFSYVTNPIdpqeISVERILLANKIGGMPMIGVKK 156
Cdd:COG0463    83 GDYIAFLDADDQLDPEKLEELVAALEEGP-ADLVYGSRLIREGESDLRRLGSRL----FNLVRLLTNLPDSTSGFRLFRR 157

                         170       180
                  ....*....|....*....|..
gi 1919214028 157 DLFLKIGGLStalRSLEDYDFL 178
Cdd:COG0463   158 EVLEELGFDE---GFLEDTELL 176
 
Name Accession Description Interval E-value
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-178 1.09e-30

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 114.41  E-value: 1.09e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   1 MFSIIVPSYNRKEEIPALLESLTKQTTYNFDVVIVDDCSK-EPVEVTQSYPFA---VKVIRNETNQGAAESRNIGVRNAD 76
Cdd:COG0463     3 LVSVVIPTYNEEEYLEEALESLLAQTYPDFEIIVVDDGSTdGTAEILRELAAKdprIRVIRLERNRGKGAARNAGLAAAR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028  77 NEWLLFLDDDDRFANDKCQKLADVIAEHPdVNFVYHPAKCEMVNEGFSYVTNPIdpqeISVERILLANKIGGMPMIGVKK 156
Cdd:COG0463    83 GDYIAFLDADDQLDPEKLEELVAALEEGP-ADLVYGSRLIREGESDLRRLGSRL----FNLVRLLTNLPDSTSGFRLFRR 157

                         170       180
                  ....*....|....*....|..
gi 1919214028 157 DLFLKIGGLStalRSLEDYDFL 178
Cdd:COG0463   158 EVLEELGFDE---GFLEDTELL 176
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 4-190 1.87e-29

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 109.52  E-value: 1.87e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   4 IIVPSYNRKEEIPALLESLTKQTTYNFDVVIVDDCSK-EPVEVTQSY---PFAVKVIRNETNQGAAESRNIGVRNADNEW 79
Cdd:cd00761     1 VIIPAYNEEPYLERCLESLLAQTYPNFEVIVVDDGSTdGTLEILEEYakkDPRVIRVINEENQGLAAARNAGLKAARGEY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028  80 LLFLDDDDRFANDKCQKLADVIAEHPDVNFVYhpakcemvnegfsyvtnpidpqeisverillankigGMPMIGVKKDLF 159
Cdd:cd00761    81 ILFLDADDLLLPDWLERLVAELLADPEADAVG------------------------------------GPGNLLFRRELL 124

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1919214028 160 LKIGGLSTALRSLEDYDFLLKLVQDPTFKAY 190
Cdd:cd00761   125 EEIGGFDEALLSGEEDDDFLLRLLRGGKVAF 155
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 3-120 2.71e-29

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 109.41  E-value: 2.71e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   3 SIIVPSYNRKEEIPALLESLTKQTTYNFDVVIVDDCSK-EPVEVTQSY---PFAVKVIRNETNQGAAESRNIGVRNADNE 78
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQTYPNFEIIVVDDGSTdGTVEIAEEYakkDPRVRVIRLPENRGKAGARNAGLRAATGD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1919214028  79 WLLFLDDDDRFANDKCQKLADVIAEHPDVNFVYHPAKCEMVN 120
Cdd:pfam00535  81 YIAFLDADDEVPPDWLEKLVEALEEDGADVVVGSRYVIFGET 122
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 1-107 1.29e-11

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 63.91  E-value: 1.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   1 MFSIIVPSYNRKEEIPALLESLTKQTTYNFDVVIVDDCSK-EPVEVTQSY----PfAVKVIRNEtNQGAAESRNIGVRNA 75
Cdd:PRK10073    7 KLSIIIPLYNAGKDFRAFMESLIAQTWTALEIIIVNDGSTdNSVEIAKHYaenyP-HVRLLHQA-NAGVSVARNTGLAVA 84

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1919214028  76 DNEWLLFLDDDDRFANDKCQKLADV-IAEHPDV 107
Cdd:PRK10073   85 TGKYVAFPDADDVVYPTMYETLMTMaLEDDLDV 117
EPS_HpsE NF038302
hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;
2-86 8.50e-10

hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;


Pssm-ID: 439602 [Multi-domain]  Cd Length: 307  Bit Score: 58.65  E-value: 8.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   2 FSIIVPSYNRKEEIPALLESLTKQTT---YNFDVVIVDDCSK-EPVEVTQSY------PFAVKVIRnETNQGAAESRNIG 71
Cdd:NF038302    3 FTVAIPTYNGANRLPEVLERLRSQIGtesLSWEIIVVDNNSTdNTAQVVQEYqknwpsPYPLRYCF-EPQQGAAFARQRA 81

                          90
                  ....*....|....*
gi 1919214028  72 VRNADNEWLLFLDDD 86
Cdd:NF038302   82 IQEAKGELIGFLDDD 96
 
Name Accession Description Interval E-value
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 1-178 1.09e-30

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 114.41  E-value: 1.09e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   1 MFSIIVPSYNRKEEIPALLESLTKQTTYNFDVVIVDDCSK-EPVEVTQSYPFA---VKVIRNETNQGAAESRNIGVRNAD 76
Cdd:COG0463     3 LVSVVIPTYNEEEYLEEALESLLAQTYPDFEIIVVDDGSTdGTAEILRELAAKdprIRVIRLERNRGKGAARNAGLAAAR 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028  77 NEWLLFLDDDDRFANDKCQKLADVIAEHPdVNFVYHPAKCEMVNEGFSYVTNPIdpqeISVERILLANKIGGMPMIGVKK 156
Cdd:COG0463    83 GDYIAFLDADDQLDPEKLEELVAALEEGP-ADLVYGSRLIREGESDLRRLGSRL----FNLVRLLTNLPDSTSGFRLFRR 157

                         170       180
                  ....*....|....*....|..
gi 1919214028 157 DLFLKIGGLStalRSLEDYDFL 178
Cdd:COG0463   158 EVLEELGFDE---GFLEDTELL 176
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 4-190 1.87e-29

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 109.52  E-value: 1.87e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   4 IIVPSYNRKEEIPALLESLTKQTTYNFDVVIVDDCSK-EPVEVTQSY---PFAVKVIRNETNQGAAESRNIGVRNADNEW 79
Cdd:cd00761     1 VIIPAYNEEPYLERCLESLLAQTYPNFEVIVVDDGSTdGTLEILEEYakkDPRVIRVINEENQGLAAARNAGLKAARGEY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028  80 LLFLDDDDRFANDKCQKLADVIAEHPDVNFVYhpakcemvnegfsyvtnpidpqeisverillankigGMPMIGVKKDLF 159
Cdd:cd00761    81 ILFLDADDLLLPDWLERLVAELLADPEADAVG------------------------------------GPGNLLFRRELL 124

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1919214028 160 LKIGGLSTALRSLEDYDFLLKLVQDPTFKAY 190
Cdd:cd00761   125 EEIGGFDEALLSGEEDDDFLLRLLRGGKVAF 155
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
 3-120 2.71e-29

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 109.41  E-value: 2.71e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   3 SIIVPSYNRKEEIPALLESLTKQTTYNFDVVIVDDCSK-EPVEVTQSY---PFAVKVIRNETNQGAAESRNIGVRNADNE 78
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNQTYPNFEIIVVDDGSTdGTVEIAEEYakkDPRVRVIRLPENRGKAGARNAGLRAATGD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1919214028  79 WLLFLDDDDRFANDKCQKLADVIAEHPDVNFVYHPAKCEMVN 120
Cdd:pfam00535  81 YIAFLDADDEVPPDWLEKLVEALEEDGADVVVGSRYVIFGET 122
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
1-100 3.09e-28

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 107.77  E-value: 3.09e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   1 MFSIIVPSYNRKEEIPALLESLTKQTTYNFDVVIVDDCSKEP-VEVTQSYPFA-VKVIRNETNQGAAESRNIGVRNADNE 78
Cdd:COG1216     4 KVSVVIPTYNRPELLRRCLESLLAQTYPPFEVIVVDNGSTDGtAELLAALAFPrVRVIRNPENLGFAAARNLGLRAAGGD 83

                          90       100
                  ....*....|....*....|..
gi 1919214028  79 WLLFLDDDDRFANDKCQKLADV 100
Cdd:COG1216    84 YLLFLDDDTVVEPDWLERLLAA 105
GT_2_WfgS_like cd06433
WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella ...
 3-202 1.81e-23

WfgS and WfeV are involved in O-antigen biosynthesis; Escherichia coli WfgS and Shigella dysenteriae WfeV are glycosyltransferase 2 family enzymes involved in O-antigen biosynthesis. GT-2 enzymes have GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133055 [Multi-domain]  Cd Length: 202  Bit Score: 94.92  E-value: 1.81e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   3 SIIVPSYNRKEEIPALLESLTKQTTYNFDVVIVDDCSK-EPVEVTQSYPFAVKVIRNETNQGAAESRNIGVRNADNEWLL 81
Cdd:cd06433     1 SIITPTYNQAETLEETIDSVLSQTYPNIEYIVIDGGSTdGTVDIIKKYEDKITYWISEPDKGIYDAMNKGIALATGDIIG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028  82 FLDDDDRFANDKCQKLADVIAEHPDVNFVYhpAKCEMVNEGfSYVTNPIDPQEISVERILlankiGGMPM----IGVKKD 157
Cdd:cd06433    81 FLNSDDTLLPGALLAVVAAFAEHPEVDVVY--GDVLLVDEN-GRVIGRRRPPPFLDKFLL-----YGMPIchqaTFFRRS 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1919214028 158 LFLKIGGLSTALRSLEDYDFLLKLVQDPTFKAYkVAEPLTYCTFH 202
Cdd:cd06433   153 LFEKYGGFDESYRIAADYDLLLRLLLAGKIFKY-LPEVLAAFRLG 196
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 4-110 6.48e-22

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 89.93  E-value: 6.48e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   4 IIVPSYNRKEEIPALLESLTKQTTYNFDVVIVDDCSKEP-VEVTQSYPFAVKVIRNETNQGAAESRNIGVRNADNEWLLF 82
Cdd:cd04186     1 IIIVNYNSLEYLKACLDSLLAQTYPDFEVIVVDNASTDGsVELLRELFPEVRLIRNGENLGFGAGNNQGIREAKGDYVLL 80

                          90       100
                  ....*....|....*....|....*...
gi 1919214028  83 LDDDDRFANDKCQKLADVIAEHPDVNFV 110
Cdd:cd04186    81 LNPDTVVEPGALLELLDAAEQDPDVGIV 108
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
 2-183 3.49e-20

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 88.26  E-value: 3.49e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   2 FSIIVPSYNRKEEIPALLESLTKQT--TYNFDVVIVDDCSKEP-VEVTQSYPFA---VKVIRNETNQGAAESRNIGVRNA 75
Cdd:COG1215    31 VSVIIPAYNEEAVIEETLRSLLAQDypKEKLEVIVVDDGSTDEtAEIARELAAEyprVRVIERPENGGKAAALNAGLKAA 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028  76 DNEWLLFLDDDDRFANDKCQKLADVIaEHPDVNFVyhpakcemvneGFSYVtnpidpqeisverillankiggmpmigVK 155
Cdd:COG1215   111 RGDIVVFLDADTVLDPDWLRRLVAAF-ADPGVGAS-----------GANLA---------------------------FR 151

                         170       180
                  ....*....|....*....|....*...
gi 1919214028 156 KDLFLKIGGLSTaLRSLEDYDFLLKLVQ 183
Cdd:COG1215   152 REALEEVGGFDE-DTLGEDLDLSLRLLR 178
GT2_RfbC_Mx_like cd04184
Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene ...
 1-182 1.41e-16

Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; The rfbC gene encodes a predicted protein of 1,276 amino acids, which is required for O-antigen biosynthesis in Myxococcus xanthus. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133027 [Multi-domain]  Cd Length: 202  Bit Score: 76.47  E-value: 1.41e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   1 MFSIIVPSYNRKEE-IPALLESLTKQTTYNFDVVIVDDCSKEPVEVTQSYPFA-----VKVIRNETNQGAAESRNIGVRN 74
Cdd:cd04184     2 LISIVMPVYNTPEKyLREAIESVRAQTYPNWELCIADDASTDPEVKRVLKKYAaqdprIKVVFREENGGISAATNSALEL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028  75 ADNEWLLFLDDDDRFANDKCQKLADVIAEHPDVNFVY-HPAKCEMVNEGFSYVTNPidpqEISVERILLANKIGGMPMig 153
Cdd:cd04184    82 ATGEFVALLDHDDELAPHALYEVVKALNEHPDADLIYsDEDKIDEGGKRSEPFFKP----DWSPDLLLSQNYIGHLLV-- 155

                         170       180
                  ....*....|....*....|....*....
gi 1919214028 154 VKKDLFLKIGGLSTALRSLEDYDFLLKLV 182
Cdd:cd04184   156 YRRSLVRQVGGFREGFEGAQDYDLVLRVS 184
CESA_like cd06423
CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily ...
 4-167 5.99e-15

CESA_like is the cellulose synthase superfamily; The cellulose synthase (CESA) superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins. Cellulose synthase catalyzes the polymerization reaction of cellulose, an aggregate of unbranched polymers of beta-1,4-linked glucose residues in plants, most algae, some bacteria and fungi, and even some animals. In bacteria, algae and lower eukaryotes, there is a second unrelated type of cellulose synthase (Type II), which produces acylated cellulose, a derivative of cellulose. Chitin synthase catalyzes the incorporation of GlcNAc from substrate UDP-GlcNAc into chitin, which is a linear homopolymer of beta-(1,4)-linked GlcNAc residues and Glucan Biosynthesis protein catalyzes the elongation of beta-1,2 polyglucose chains of Glucan.


Pssm-ID: 133045 [Multi-domain]  Cd Length: 180  Bit Score: 71.49  E-value: 5.99e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   4 IIVPSYNRKEEIPALLESLTKQTTYNFDVVIVDDCSK-----EPVEVTQSYPFAVKVIRNETNQGAAESRNIGVRNADNE 78
Cdd:cd06423     1 IIVPAYNEEAVIERTIESLLALDYPKLEVIVVDDGSTddtleILEELAALYIRRVLVVRDKENGGKAGALNAGLRHAKGD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028  79 WLLFLDDDDRFANDKCQKLADVIAEHPDVNFVYhpAKCEMVNEGFSYVTNpidpqEISVERILLAN-------KIGGMPM 151
Cdd:cd06423    81 IVVVLDADTILEPDALKRLVVPFFADPKVGAVQ--GRVRVRNGSENLLTR-----LQAIEYLSIFRlgrraqsALGGVLV 153

                         170       180
                  ....*....|....*....|.
gi 1919214028 152 IG-----VKKDLFLKIGGLST 167
Cdd:cd06423   154 LSgafgaFRREALREVGGWDE 174
GT2_Chondriotin_Pol_N cd06420
N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin ...
 4-86 1.21e-13

N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Chondroitin polymerase is a two domain, bi-functional protein. The N-terminal domain functions as a GalNAc transferase. The bacterial chondroitin polymerase catalyzes elongation of the chondroitin chain by alternatively transferring the GlcUA and GalNAc moiety from UDP-GlcUA and UDP-GalNAc to the non-reducing ends of the chondroitin chain. The enzyme consists of N-terminal and C-terminal domains in which the two active sites catalyze the addition of GalNAc and GlcUA, respectively. Chondroitin chains range from 40 to over 100 repeating units of the disaccharide. Sulfated chondroitins are involved in the regulation of various biological functions such as central nervous system development, wound repair, infection, growth factor signaling, and morphogenesis, in addition to its conventional structural roles. In Caenorhabditis elegans, chondroitin is an essential factor for the worm to undergo cytokinesis and cell division. Chondroitin is synthesized as proteoglycans, sulfated and secreted to the cell surface or extracellular matrix.


Pssm-ID: 133042 [Multi-domain]  Cd Length: 182  Bit Score: 67.60  E-value: 1.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   4 IIVPSYNRKEEIPALLESLTKQTTYNFDVVIVDDCSKE-PVEVTQSY----PFAVKVIRNEtNQG--AAESRNIGVRNAD 76
Cdd:cd06420     1 LIITTYNRPEALELVLKSVLNQSILPFEVIIADDGSTEeTKELIEEFksqfPIPIKHVWQE-DEGfrKAKIRNKAIAAAK 79

                          90
                  ....*....|
gi 1919214028  77 NEWLLFLDDD 86
Cdd:cd06420    80 GDYLIFIDGD 89
PRK10073 PRK10073
putative glycosyl transferase; Provisional
 1-107 1.29e-11

putative glycosyl transferase; Provisional


Pssm-ID: 182223 [Multi-domain]  Cd Length: 328  Bit Score: 63.91  E-value: 1.29e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   1 MFSIIVPSYNRKEEIPALLESLTKQTTYNFDVVIVDDCSK-EPVEVTQSY----PfAVKVIRNEtNQGAAESRNIGVRNA 75
Cdd:PRK10073    7 KLSIIIPLYNAGKDFRAFMESLIAQTWTALEIIIVNDGSTdNSVEIAKHYaenyP-HVRLLHQA-NAGVSVARNTGLAVA 84

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1919214028  76 DNEWLLFLDDDDRFANDKCQKLADV-IAEHPDV 107
Cdd:PRK10073   85 TGKYVAFPDADDVVYPTMYETLMTMaLEDDLDV 117
GT_2_like_d cd04196
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 3-152 1.88e-11

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133039 [Multi-domain]  Cd Length: 214  Bit Score: 62.26  E-value: 1.88e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   3 SIIVPSYNRKEEIPALLESLTKQTTYNFDVVIVDDCSK-EPVEV----TQSYPFAVKVIRNETNQGAAESRNIGVRNADN 77
Cdd:cd04196     1 AVLMATYNGEKYLREQLDSILAQTYKNDELIISDDGSTdGTVEIikeyIDKDPFIIILIRNGKNLGVARNFESLLQAADG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028  78 EWLLFLDDDDRFANDKCQKLADVIAEHPDVNFVYHpaKCEMVNEGFS------YVTNPIDPQeISVERILLANKIGGMPM 151
Cdd:cd04196    81 DYVFFCDQDDIWLPDKLERLLKAFLKDDKPLLVYS--DLELVDENGNpigesfFEYQKIKPG-TSFNNLLFQNVVTGCTM 157


                  .
gi 1919214028 152 I 152
Cdd:cd04196   158 A 158
Succinoglycan_BP_ExoA cd02525
ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA ...
 3-183 2.01e-11

ExoA is involved in the biosynthesis of succinoglycan; Succinoglycan Biosynthesis Protein ExoA catalyzes the formation of a beta-1,3 linkage of the second sugar (glucose) of the succinoglycan with the galactose on the lipid carrie. Succinoglycan is an acidic exopolysaccharide that is important for invasion of the nodules. Succinoglycan is a high-molecular-weight polymer composed of repeating octasaccharide units. These units are synthesized on membrane-bound isoprenoid lipid carriers, beginning with galactose followed by seven glucose molecules, and modified by the addition of acetate, succinate, and pyruvate. ExoA is a membrane protein with a transmembrance domain at c-terminus.


Pssm-ID: 133016 [Multi-domain]  Cd Length: 249  Bit Score: 62.63  E-value: 2.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   3 SIIVPSYNRKEEIPALLESLTKQTTY--NFDVVIVDDCSK-EPVEVTQSYP---FAVKVIRNET-NQGAAesRNIGVRNA 75
Cdd:cd02525     3 SIIIPVRNEEKYIEELLESLLNQSYPkdLIEIIVVDGGSTdGTREIVQEYAakdPRIRLIDNPKrIQSAG--LNIGIRNS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028  76 DNEWLLFLDDDDRFANDKCQKLADVIAEhPDVnfvyhpakcemVNEGFSYVTNPIDPQEISVERIL-------------L 142
Cdd:cd02525    81 RGDIIIRVDAHAVYPKDYILELVEALKR-TGA-----------DNVGGPMETIGESKFQKAIAVAQssplgsggsayrgG 148

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1919214028 143 ANKIGGM---PMIGVKKDLFLKIGGLSTALRSLEDYDFLLKLVQ 183
Cdd:cd02525   149 AVKIGYVdtvHHGAYRREVFEKVGGFDESLVRNEDAELNYRLRK 192
PRK10018 PRK10018
colanic acid biosynthesis glycosyltransferase WcaA;
1-182 6.49e-11

colanic acid biosynthesis glycosyltransferase WcaA;


Pssm-ID: 182197 [Multi-domain]  Cd Length: 279  Bit Score: 61.55  E-value: 6.49e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   1 MFSIIVPSYNRKEEIPALLESLTKQTTYNFDVVIVDDCSKEpVEVTQSYPFA-----VKVIRNETNQGAAESRNIGVRNA 75
Cdd:PRK10018    6 LISIYMPTWNRQQLAIRAIKSVLRQDYSNWEMIIVDDCSTS-WEQLQQYVTAlndprITYIHNDINSGACAVRNQAIMLA 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028  76 DNEWLLFLDDDDRFANDkcqKLADVIAEHPDVN---FVYhpaKCEMVNEGFSY---VTNPIDPQEISVERILLANKIGGM 149
Cdd:PRK10018   85 QGEYITGIDDDDEWTPN---RLSVFLAHKQQLVthaFLY---ANDYVCQGEVYsqpASLPLYPKSPYSRRLFYKRNIIGN 158

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1919214028 150 PMIG----VKKDLFlkigglSTALRSLEDYDFLLKLV 182
Cdd:PRK10018  159 QVFTwawrFKECLF------DTELKAAQDYDIFLRMV 189
DPG_synthase cd04188
DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate ...
 4-86 6.31e-10

DPG_synthase is involved in protein N-linked glycosylation; UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate.


Pssm-ID: 133031 [Multi-domain]  Cd Length: 211  Bit Score: 57.96  E-value: 6.31e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   4 IIVPSYNRKEEIPALLES----LTKQTTYNFDVVIVDDCSK-EPVEV----TQSYPFAVKVIRNETNQGAAESRNIGVRN 74
Cdd:cd04188     1 VVIPAYNEEKRLPPTLEEaveyLEERPSFSYEIIVVDDGSKdGTAEVarklARKNPALIRVLTLPKNRGKGGAVRAGMLA 80

                          90
                  ....*....|..
gi 1919214028  75 ADNEWLLFLDDD 86
Cdd:cd04188    81 ARGDYILFADAD 92
GT2_AmsE_like cd04195
GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a ...
 3-198 8.00e-10

GT2_AmsE_like is involved in exopolysaccharide amylovora biosynthesis; AmsE is a glycosyltransferase involved in exopolysaccharide amylovora biosynthesis in Erwinia amylovora. Amylovara is one of the three exopolysaccharide produced by E. amylovora. Amylovara-deficient mutants are non-pathogenic. It is a subfamily of Glycosyltransferase Family GT2, which includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.


Pssm-ID: 133038 [Multi-domain]  Cd Length: 201  Bit Score: 57.32  E-value: 8.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   3 SIIVPSYNRkeEIPALL----ESLTKQTTYNFDVVIVDDC----SKEPV--EVTQSYPFavKVIRNETNQGAAESRNIGV 72
Cdd:cd04195     1 SVLMSVYIK--EKPEFLrealESILKQTLPPDEVVLVKDGpvtqSLNEVleEFKRKLPL--KVVPLEKNRGLGKALNEGL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028  73 RNADNEWLLFLDDDDRFANDKCQKLADVIAEHPDVNFVYHPAkcemvnEGFSYVTNPIdpqeISVERILLANKIGGM--- 149
Cdd:cd04195    77 KHCTYDWVARMDTDDISLPDRFEKQLDFIEKNPEIDIVGGGV------LEFDSDGNDI----GKRRLPTSHDDILKFarr 146

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1919214028 150 ------PMIGVKKDLFLKIGGLSTALRsLEDYDFLLKLVQDpTFKAYKVAEPLTY 198
Cdd:cd04195   147 rspfnhPTVMFRKSKVLAVGGYQDLPL-VEDYALWARMLAN-GARFANLPEILVK 199
EPS_HpsE NF038302
hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;
2-86 8.50e-10

hormogonium polysaccharide biosynthesis glycosyltransferase HpsE;


Pssm-ID: 439602 [Multi-domain]  Cd Length: 307  Bit Score: 58.65  E-value: 8.50e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   2 FSIIVPSYNRKEEIPALLESLTKQTT---YNFDVVIVDDCSK-EPVEVTQSY------PFAVKVIRnETNQGAAESRNIG 71
Cdd:NF038302    3 FTVAIPTYNGANRLPEVLERLRSQIGtesLSWEIIVVDNNSTdNTAQVVQEYqknwpsPYPLRYCF-EPQQGAAFARQRA 81

                          90
                  ....*....|....*
gi 1919214028  72 VRNADNEWLLFLDDD 86
Cdd:NF038302   82 IQEAKGELIGFLDDD 96
GT_2_like_a cd02522
GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; ...
 3-83 1.18e-09

GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Glycosyltransferase family 2 (GT-2) subfamily of unknown function. GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133013 [Multi-domain]  Cd Length: 221  Bit Score: 57.20  E-value: 1.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   3 SIIVPSYNRKEEIPALLESLTKQTTYNFDVVIVDDCSKEP-VEVTQSypFAVKVIRneTNQGAAESRNIGVRNADNEWLL 81
Cdd:cd02522     2 SIIIPTLNEAENLPRLLASLRRLNPLPLEIIVVDGGSTDGtVAIARS--AGVVVIS--SPKGRARQMNAGAAAARGDWLL 77


                  ..
gi 1919214028  82 FL 83
Cdd:cd02522    78 FL 79
DPM_DPG-synthase_like cd04179
DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the ...
 4-86 1.70e-09

DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. The UDP-glucose:dolichyl-phosphate glucosyltransferase (DPG_synthase) is a transmembrane-bound enzyme of the endoplasmic reticulum involved in protein N-linked glycosylation. This enzyme catalyzes the transfer of glucose from UDP-glucose to dolichyl phosphate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133022 [Multi-domain]  Cd Length: 185  Bit Score: 56.04  E-value: 1.70e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   4 IIVPSYNRKEEIPALLESLTK--QTTYNFDVVIVDDCSKEP-VEVTQSYP---FAVKVIRNETNQGAAESRNIGVRNADN 77
Cdd:cd04179     1 VVIPAYNEEENIPELVERLLAvlEEGYDYEIIVVDDGSTDGtAEIARELAarvPRVRVIRLSRNFGKGAAVRAGFKAARG 80


                  ....*....
gi 1919214028  78 EWLLFLDDD 86
Cdd:cd04179    81 DIVVTMDAD 89
GT_2_like_b cd04185
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 5-97 4.07e-08

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133028 [Multi-domain]  Cd Length: 202  Bit Score: 52.25  E-value: 4.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   5 IVPSYNRKEEIPALLESLTKQTTYNFDVVIVDDCS----KEPVEvTQSYPFAVKVIRNETNQGAAESRNIGVRNA---DN 77
Cdd:cd04185     2 VVVTYNRLDLLKECLDALLAQTRPPDHIIVIDNAStdgtAEWLT-SLGDLDNIVYLRLPENLGGAGGFYEGVRRAyelGY 80

                          90       100
                  ....*....|....*....|
gi 1919214028  78 EWLLFLDDDDRFANDKCQKL 97
Cdd:cd04185    81 DWIWLMDDDAIPDPDALEKL 100
pp-GalNAc-T cd02510
pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; UDP-GalNAc: polypeptide ...
 3-84 7.40e-08

pp-GalNAc-T initiates the formation of mucin-type O-linked glycans; UDP-GalNAc: polypeptide alpha-N-acetylgalactosaminyltransferases (pp-GalNAc-T) initiate the formation of mucin-type, O-linked glycans by catalyzing the transfer of alpha-N-acetylgalactosamine (GalNAc) from UDP-GalNAc to hydroxyl groups of Ser or Thr residues of core proteins to form the Tn antigen (GalNAc-a-1-O-Ser/Thr). These enzymes are type II membrane proteins with a GT-A type catalytic domain and a lectin domain located on the lumen side of the Golgi apparatus. In human, there are 15 isozymes of pp-GalNAc-Ts, representing the largest of all glycosyltransferase families. Each isozyme has unique but partially redundant substrate specificity for glycosylation sites on acceptor proteins.


Pssm-ID: 133004 [Multi-domain]  Cd Length: 299  Bit Score: 52.59  E-value: 7.40e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   3 SIIVPSYNrkEEIPALLESLTkqTTYNF-------DVVIVDDCSKEPV------EVTQSYPFAVKVIRNETNQGAAESRN 69
Cdd:cd02510     1 SVIIIFHN--EALSTLLRTVH--SVINRtppellkEIILVDDFSDKPElkllleEYYKKYLPKVKVLRLKKREGLIRARI 76

                          90
                  ....*....|....*
gi 1919214028  70 IGVRNADNEWLLFLD 84
Cdd:cd02510    77 AGARAATGDVLVFLD 91
DPM1_like_bac cd04187
Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes ...
 4-86 2.60e-07

Bacterial DPM1_like enzymes are related to eukaryotic DPM1; A family of bacterial enzymes related to eukaryotic DPM1; Although the mechanism of eukaryotic enzyme is well studied, the mechanism of the bacterial enzymes is not well understood. The eukaryotic DPM1 is the catalytic subunit of eukaryotic Dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. The enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133030 [Multi-domain]  Cd Length: 181  Bit Score: 49.78  E-value: 2.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   4 IIVPSYNRKEEIPALLESLTK---QTTYNFDVVIVDDCSKEP-----VEVTQSYPFaVKVIRNetnqgaaeSRNIG---- 71
Cdd:cd04187     1 IVVPVYNEEENLPELYERLKAvleSLGYDYEIIFVDDGSTDRtleilRELAARDPR-VKVIRL--------SRNFGqqaa 71

                          90
                  ....*....|....*....
gi 1919214028  72 ----VRNADNEWLLFLDDD 86
Cdd:cd04187    72 llagLDHARGDAVITMDAD 90
PTZ00260 PTZ00260
dolichyl-phosphate beta-glucosyltransferase; Provisional
 2-103 3.32e-07

dolichyl-phosphate beta-glucosyltransferase; Provisional


Pssm-ID: 240336 [Multi-domain]  Cd Length: 333  Bit Score: 50.92  E-value: 3.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   2 FSIIVPSYNRKEEIPALLES--------LTKQTTYNFDVVIVDDCSKE-PVEVTQSY-------PFAVKVIRNETNQGAA 65
Cdd:PTZ00260   72 LSIVIPAYNEEDRLPKMLKEtikylesrSRKDPKFKYEIIIVNDGSKDkTLKVAKDFwrqninpNIDIRLLSLLRNKGKG 151

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1919214028  66 ESRNIGVRNADNEWLLFLDDDDRFANDKCQKLADVIAE 103
Cdd:PTZ00260  152 GAVRIGMLASRGKYILMVDADGATDIDDFDKLEDIMLK 189
GT_2_like_e cd04192
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
 4-190 9.55e-07

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133035 [Multi-domain]  Cd Length: 229  Bit Score: 48.82  E-value: 9.55e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   4 IIVPSYNRKEEIPALLESLTKQT--TYNFDVVIVDDCS----KEPVEVTQSYP-FAVKVIRN--ETNQGAAESRNIGVRN 74
Cdd:cd04192     1 VVIAARNEAENLPRLLQSLSALDypKEKFEVILVDDHStdgtVQILEFAAAKPnFQLKILNNsrVSISGKKNALTTAIKA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028  75 ADNEWLLFLDDDdrfandkCQKLADVIAEhpdvnFVYHPAKcemvnEGFSYVTNPIDPQE-----ISVERILLANKIG-- 147
Cdd:cd04192    81 AKGDWIVTTDAD-------CVVPSNWLLT-----FVAFIQK-----EQIGLVAGPVIYFKgksllAKFQRLDWLSLLGli 143

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1919214028 148 ------GMPMIGV------KKDLFLKIGGLST--ALRSlEDYDFLLKLVQDPTFKAY 190
Cdd:cd04192   144 agsfglGKPFMCNganmayRKEAFFEVGGFEGndHIAS-GDDELLLAKVASKYPKVA 199
Glyco_tranf_2_3 pfam13641
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 1-204 2.14e-06

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 433372 [Multi-domain]  Cd Length: 230  Bit Score: 47.75  E-value: 2.14e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   1 MFSIIVPSYNRKEEIPALLESLTKQTTYNFDVVIVDDCSKEPV-----EVTQSYPFA-VKVIRNE---TNQGAAESRNIG 71
Cdd:pfam13641   3 DVSVVVPAFNEDSVLGRVLEAILAQPYPPVEVVVVVNPSDAETldvaeEIAARFPDVrLRVIRNArllGPTGKSRGLNHG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028  72 VRNADNEWLLFLDDDDRFANDKCQKLADvIAEHPDVNFVYHPAKCEMvnegFSYVTNPIDPQEISV---ERILLANKIGG 148
Cdd:pfam13641  83 FRAVKSDLVVLHDDDSVLHPGTLKKYVQ-YFDSPKVGAVGTPVFSLN----RSTMLSALGALEFALrhlRMMSLRLALGV 157

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028 149 MPMIG----VKKDLFLKIGGLSTALRSLEDYDFLLKLVQDpTFKAYKVAEPLTYCTFHTK 204
Cdd:pfam13641 158 LPLSGagsaIRREVLKELGLFDPFFLLGDDKSLGRRLRRH-GWRVAYAPDAAVRTVFPTY 216
Beta4Glucosyltransferase cd02511
UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of ...
 1-111 7.67e-06

UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; UDP-glucose: lipooligosaccharide (LOS) beta-1-4-glucosyltransferase catalyzes the addition of the first residue, glucose, of the lacto-N-neotetrase structure to HepI of the LOS inner core. LOS is the major constituent of the outer leaflet of the outer membrane of gram-positive bacteria. It consists of a short oligosaccharide chain of variable composition (alpha chain) attached to a branched inner core which is lined in turn to lipid A. Beta 1,4 glucosyltransferase is required to attach the alpha chain to the inner core.


Pssm-ID: 133005 [Multi-domain]  Cd Length: 229  Bit Score: 46.13  E-value: 7.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   1 MFSIIVPSYNRKEEIPALLESLtkqttYNF--DVVIVDDCSK-EPVEVTQSYPfaVKVIRNEtNQGAAESRNIGVRNADN 77
Cdd:cd02511     1 TLSVVIITKNEERNIERCLESV-----KWAvdEIIVVDSGSTdRTVEIAKEYG--AKVYQRW-WDGFGAQRNFALELATN 72

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1919214028  78 EWLLFLDDDDRFANDKCQKLADVIAEHPDVNFVY 111
Cdd:cd02511    73 DWVLSLDADERLTPELADEILALLATDDYDGYYV 106
GT2_RfbF_like cd02526
RfbF is a putative dTDP-rhamnosyl transferase; Shigella flexneri RfbF protein is a putative ...
 3-108 1.61e-05

RfbF is a putative dTDP-rhamnosyl transferase; Shigella flexneri RfbF protein is a putative dTDP-rhamnosyl transferase. dTDP rhamnosyl transferases of Shigella flexneri add rhamnose sugars to N-acetyl-glucosamine in the O-antigen tetrasaccharide repeat. Lipopolysaccharide O antigens are important virulence determinants for many bacteria. The variations of sugar composition, the sequence of the sugars and the linkages in the O antigen provide structural diversity of the O antigen.


Pssm-ID: 133017 [Multi-domain]  Cd Length: 237  Bit Score: 44.97  E-value: 1.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   3 SIIVpSYN-RKEEIPALLESLTKQTTYnfdVVIVDDCSKEPVEVTQSYPFA-VKVIRNETNQGAAESRNIGVRNA-DN-- 77
Cdd:cd02526     1 AVVV-TYNpDLSKLKELLAALAEQVDK---VVVVDNSSGNDIELRLRLNSEkIELIHLGENLGIAKALNIGIKAAlENga 76

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1919214028  78 EWLLFLDDDDRFANDKCQKL-ADVIAEHPDVN 108
Cdd:cd02526    77 DYVLLFDQDSVPPPDMVEKLlAYKILSDKNSN 108
Glyco_tranf_2_2 pfam10111
Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include ...
 3-196 2.12e-05

Glycosyltransferase like family 2; Members of this family of prokaryotic proteins include putative glucosyltransferase, which are involved in bacterial capsule biosynthesis.


Pssm-ID: 313356 [Multi-domain]  Cd Length: 276  Bit Score: 44.96  E-value: 2.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   3 SIIVPSYNrKEEIPALLESLTKQTTY---NFDVVIVDDCSKEP-VEVTQSYPFAVKVI----RNETNQGAAESRNIGVRN 74
Cdd:pfam10111   1 SVVIPVYN-GEKTHWIQERILNQTFQydpEFELIIINDGSTDKtLEEVSSIKDHNLQVyypnAPDTTYSLAASRNRGTSH 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028  75 ADNEWLLFLDDDDRFANDKCQKLADV-----IAEHPDVNFV-----YHPAKCEMVNEGfSYVTNPIDpqeisVERILLAN 144
Cdd:pfam10111  80 AIGEYISFIDGDCLWSPDKFEKQLKIatslaLQENIQAAVVlpvtdLNDESSNFLRRG-GDLTASGD-----VLRDLLVF 153

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1919214028 145 KIGGMPMIG-------VKKDLFLKIGGLSTALR--SLEDYDFLLKLVqdptfKAYKVAEPL 196
Cdd:pfam10111 154 YSPLAIFFApnssnalINRQAFIEVGGFDESFRghGAEDFDIFLRLA-----ARYPFVAVM 209
CESA_like_1 cd06439
CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of ...
 2-98 4.28e-05

CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; This is a subfamily of cellulose synthase (CESA) superfamily. CESA superfamily includes a wide variety of glycosyltransferase family 2 enzymes that share the common characteristic of catalyzing the elongation of polysaccharide chains. The members of the superfamily include cellulose synthase catalytic subunit, chitin synthase, glucan biosynthesis protein and other families of CESA-like proteins.


Pssm-ID: 133061 [Multi-domain]  Cd Length: 251  Bit Score: 44.11  E-value: 4.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   2 FSIIVPSYNRKEEIPALLESLTkQTTY---NFDVVIVDDCSKE-PVEVTQSYP-FAVKVIRNETNQGAAESRNIGVRNAD 76
Cdd:cd06439    31 VTIIIPAYNEEAVIEAKLENLL-ALDYprdRLEIIVVSDGSTDgTAEIAREYAdKGVKLLRFPERRGKAAALNRALALAT 109

                          90       100
                  ....*....|....*....|..
gi 1919214028  77 NEWLLFLDDDDRFANDKCQKLA 98
Cdd:cd06439   110 GEIVVFTDANALLDPDALRLLV 131
DPM1_like cd06442
DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to ...
 4-40 5.30e-05

DPM1_like represents putative enzymes similar to eukaryotic DPM1; Proteins similar to eukaryotic DPM1, including enzymes from bacteria and archaea; DPM1 is the catalytic subunit of eukaryotic dolichol-phosphate mannose (DPM) synthase. DPM synthase is required for synthesis of the glycosylphosphatidylinositol (GPI) anchor, N-glycan precursor, protein O-mannose, and C-mannose. In higher eukaryotes,the enzyme has three subunits, DPM1, DPM2 and DPM3. DPM is synthesized from dolichol phosphate and GDP-Man on the cytosolic surface of the ER membrane by DPM synthase and then is flipped onto the luminal side and used as a donor substrate. In lower eukaryotes, such as Saccharomyces cerevisiae and Trypanosoma brucei, DPM synthase consists of a single component (Dpm1p and TbDpm1, respectively) that possesses one predicted transmembrane region near the C terminus for anchoring to the ER membrane. In contrast, the Dpm1 homologues of higher eukaryotes, namely fission yeast, fungi, and animals, have no transmembrane region, suggesting the existence of adapter molecules for membrane anchoring. This family also includes bacteria and archaea DPM1_like enzymes. However, the enzyme structure and mechanism of function are not well understood. This protein family belongs to Glycosyltransferase 2 superfamily.


Pssm-ID: 133062 [Multi-domain]  Cd Length: 224  Bit Score: 43.29  E-value: 5.30e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1919214028   4 IIVPSYNRKEEIPALLESLTKQTT-YNFDVVIVDDCSK 40
Cdd:cd06442     1 IIIPTYNERENIPELIERLDAALKgIDYEIIVVDDNSP 38
PLN02726 PLN02726
dolichyl-phosphate beta-D-mannosyltransferase
 2-39 4.71e-04

dolichyl-phosphate beta-D-mannosyltransferase


Pssm-ID: 215385 [Multi-domain]  Cd Length: 243  Bit Score: 40.84  E-value: 4.71e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1919214028   2 FSIIVPSYNRKEEIPALLESLTK--QTTYNFDVVIVDDCS 39
Cdd:PLN02726   11 YSIIVPTYNERLNIALIVYLIFKalQDVKDFEIIVVDDGS 50
GT2_HAS cd06434
Hyaluronan synthases catalyze polymerization of hyaluronan; Hyaluronan synthases (HASs) are ...
 3-86 2.35e-03

Hyaluronan synthases catalyze polymerization of hyaluronan; Hyaluronan synthases (HASs) are bi-functional glycosyltransferases that catalyze polymerization of hyaluronan. HASs transfer both GlcUA and GlcNAc in beta-(1,3) and beta-(1,4) linkages, respectively to the hyaluronan chain using UDP-GlcNAc and UDP-GlcUA as substrates. HA is made as a free glycan, not attached to a protein or lipid. HASs do not need a primer for HA synthesis; they initiate HA biosynthesis de novo with only UDP-GlcNAc, UDP-GlcUA, and Mg2+. Hyaluronan (HA) is a linear heteropolysaccharide composed of (1-3)-linked beta-D-GlcUA-beta-D-GlcNAc disaccharide repeats. It can be found in vertebrates and a few microbes and is typically on the cell surface or in the extracellular space, but is also found inside mammalian cells. Hyaluronan has several physiochemical and biological functions such as space filling, lubrication, and providing a hydrated matrix through which cells can migrate.


Pssm-ID: 133056 [Multi-domain]  Cd Length: 235  Bit Score: 38.77  E-value: 2.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1919214028   3 SIIVPSYNRKEEI-PALLESLTKQTTYNFDVVIvDDCSKEPVE-VTQSYPFAVKVIRNETNQGAAESRNIGVRNADNEWL 80
Cdd:cd06434     3 TVIIPVYDEDPDVfRECLRSILRQKPLEIIVVT-DGDDEPYLSiLSQTVKYGGIFVITVPHPGKRRALAEGIRHVTTDIV 81


                  ....*.
gi 1919214028  81 LFLDDD 86
Cdd:cd06434    82 VLLDSD 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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