Conserved domains on
[gi|1917925132]
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Chain A, Pre-mRNA-processing-splicing factor 8
Protein Classification
PRP8 family protein( domain architecture ID 1000292)
PRP8 family protein similar to Arabidopsis thaliana pre-mRNA-processing-splicing factor 8B that functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||||||||||||||||||||||
| PRP8 super family | cl34928 | U5 snRNP spliceosome subunit [RNA processing and modification]; |
1-1755 | 0e+00 | ||||||||||||||||||||||||
U5 snRNP spliceosome subunit [RNA processing and modification]; The actual alignment was detected with superfamily member COG5178: Pssm-ID: 227505 [Multi-domain] Cd Length: 2365 Bit Score: 2808.39 E-value: 0e+00
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| Name | Accession | Description | Interval | E-value | ||||||||||||||||||||||||
| PRP8 | COG5178 | U5 snRNP spliceosome subunit [RNA processing and modification]; |
1-1755 | 0e+00 | ||||||||||||||||||||||||
U5 snRNP spliceosome subunit [RNA processing and modification]; Pssm-ID: 227505 [Multi-domain] Cd Length: 2365 Bit Score: 2808.39 E-value: 0e+00
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| PROCN | pfam08083 | PROCN (NUC071) domain; The PROCN domain is the central domain in pre-mRNA splicing factors of ... |
395-796 | 0e+00 | ||||||||||||||||||||||||
PROCN (NUC071) domain; The PROCN domain is the central domain in pre-mRNA splicing factors of PRO8 family. Pssm-ID: 400431 Cd Length: 402 Bit Score: 866.32 E-value: 0e+00
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| Name | Accession | Description | Interval | E-value | ||||||||||||||||||||||||
| PRP8 | COG5178 | U5 snRNP spliceosome subunit [RNA processing and modification]; |
1-1755 | 0e+00 | ||||||||||||||||||||||||
U5 snRNP spliceosome subunit [RNA processing and modification]; Pssm-ID: 227505 [Multi-domain] Cd Length: 2365 Bit Score: 2808.39 E-value: 0e+00
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| PROCN | pfam08083 | PROCN (NUC071) domain; The PROCN domain is the central domain in pre-mRNA splicing factors of ... |
395-796 | 0e+00 | ||||||||||||||||||||||||
PROCN (NUC071) domain; The PROCN domain is the central domain in pre-mRNA splicing factors of PRO8 family. Pssm-ID: 400431 Cd Length: 402 Bit Score: 866.32 E-value: 0e+00
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| PRO8NT | pfam08082 | PRO8NT (NUC069), PrP8 N-terminal domain; The PRO8NT domain is found at the N-terminus of ... |
58-209 | 6.45e-115 | ||||||||||||||||||||||||
PRO8NT (NUC069), PrP8 N-terminal domain; The PRO8NT domain is found at the N-terminus of pre-mRNA splicing factors of PRO8 family. The NLS or nuclear localization signal for these spliceosome proteins begins at the start and runs for 60 residues. N-terminal to this domain is a highly variable proline-rich region. Pssm-ID: 462361 [Multi-domain] Cd Length: 152 Bit Score: 359.30 E-value: 6.45e-115
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| U6-snRNA_bdg | pfam10596 | U6-snRNA interacting domain of PrP8; This domain incorporates the interacting site for the ... |
1442-1600 | 2.65e-108 | ||||||||||||||||||||||||
U6-snRNA interacting domain of PrP8; This domain incorporates the interacting site for the U6-snRNA as part of the U4/U6.U5 tri-snRNPs complex of the spliceosome, and is the prime candidate for the role of cofactor for the spliceosome's RNA core. The essential spliceosomal protein Prp8 interacts with U5 and U6 snRNAs and with specific pre-mRNA sequences that participate in catalysis. This close association with crucial RNA sequences, together with extensive genetic evidence, suggests that Prp8 could directly affect the function of the catalytic core, perhaps acting as a splicing cofactor. Pssm-ID: 431383 Cd Length: 159 Bit Score: 341.00 E-value: 2.65e-108
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| U5_2-snRNA_bdg | pfam10597 | U5-snRNA binding site 2 of PrP8; The essential spliceosomal protein Prp8 interacts with U5 and ... |
1210-1343 | 1.02e-89 | ||||||||||||||||||||||||
U5-snRNA binding site 2 of PrP8; The essential spliceosomal protein Prp8 interacts with U5 and U6 snRNAs and with specific pre-mRNA sequences that participate in catalysis. This close association with crucial RNA sequences, together with extensive genetic evidence, suggests that Prp8 could directly affect the function of the catalytic core, perhaps acting as a splicing cofactor. Pssm-ID: 402297 Cd Length: 134 Bit Score: 286.97 E-value: 1.02e-89
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| RRM_4 | pfam10598 | RNA recognition motif of the spliceosomal PrP8; The large RNA-protein complex of the ... |
986-1077 | 6.44e-53 | ||||||||||||||||||||||||
RNA recognition motif of the spliceosomal PrP8; The large RNA-protein complex of the spliceosome catalyzes pre-mRNA splicing. One of the most conserved core proteins is PrP8 which occupies a central position in the catalytic core of the spliceosome, and has been implicated in several crucial molecular rearrangements that occur there, and has recently come under the spotlight for its role in the inherited human disease, Retinitis Pigmentosa. The RNA-recognition motif of PrP8 is highly conserved and provides a possible RNA binding centre for the 5-prime SS, BP, or 3-prime SS of pre-mRNA which are known to contact with Prp8. The most conserved regions of an RRM are defined as the RNP1 and RNP2 sequences. Recognition of RNA targets can also be modulated by a number of other factors, most notably the two loops beta1-alpha1, beta2-beta3 and the amino acid residues C-terminal to the RNP2 domain. Pssm-ID: 463163 Cd Length: 92 Bit Score: 180.13 E-value: 6.44e-53
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