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Conserved domains on  [gi|19171078|emb|CAD26468|]
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GENERAL TRANSCRIPTION FACTOR [Encephalitozoon cuniculi GB-M1]

Protein Classification

bromodomain-containing protein( domain architecture ID 11473733)

bromodomain-containing protein similar to Saccharomyces cerevisiae histone acetyltransferase GCN5, chromatin structure-remodeling complex subunit RSC4 and transcriptional activator SPT7

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 1-370 1.52e-75

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


:

Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 238.17  E-value: 1.52e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078   1 MEGEETNSGNILAEHQLKYcSQILTRLKRNSNAPPFlEPVDPVKLGIPDYPEKIKHPMDLSTIRKKLDSKEYegPEGFDG 80
Cdd:COG5076   1 LEFDEVSYSQLGRPSVLKE-EFGNELLRLVDNDSSP-FPNAPEEEGSKNLFQKQLKRMPKEYITSIVDDREP--GSMANV 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078  81 DMRLMFSNCYTYNPPGTVVHEMGKGLEAVYTDLMAGMPQEIPKKRKKTEMPAvgrPKQVKRNVKGSDGMKAEDYEFCSET 160
Cdd:COG5076  77 NDDLENVGGITYSPFEKNRPESLRFDEIVFLAIESVTPESGLGSLLMAHLKT---SVKKRKTPKIEDELLYADNKAIAKF 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078 161 LSDLVKPKHKAYNWPFLEPVDGDLVPGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKFNAPGTEVYVC 240
Cdd:COG5076 154 KKQLFLRDGRFLSSIFLGLPSKREYPDYYEIIKSPMDLLTIQKKLKNGRYKSFEEFVSDLNLMFDNCKLYNGPDSSVYVD 233

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078 241 GQEFEKAVKMHMQKVSPHDIKSRITELKRKVmsYSREIRMLESKlMEQTGEMPTSRAYSLNERVSIGNAILNMSKEQTES 320
Cdd:COG5076 234 AKELEKYFLKLIEEIPEEMLELSIKPGREER--EERESVLITNS-QAHVGAWPFLRPVSDEEVPDYYKDIRDPMDLSTKE 310

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|
gi 19171078 321 VaKIVLKNGAGEfVENDEIEVDMRTIPDHVVEEIDMYIKSINVGEDVRDE 370
Cdd:COG5076 311 L-KLRNNYYRPE-ETFVRDAKLFFDNCVMYNGEVTDYYKNANVLEDFVIK 358
 
Name Accession Description Interval E-value
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 1-370 1.52e-75

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 238.17  E-value: 1.52e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078   1 MEGEETNSGNILAEHQLKYcSQILTRLKRNSNAPPFlEPVDPVKLGIPDYPEKIKHPMDLSTIRKKLDSKEYegPEGFDG 80
Cdd:COG5076   1 LEFDEVSYSQLGRPSVLKE-EFGNELLRLVDNDSSP-FPNAPEEEGSKNLFQKQLKRMPKEYITSIVDDREP--GSMANV 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078  81 DMRLMFSNCYTYNPPGTVVHEMGKGLEAVYTDLMAGMPQEIPKKRKKTEMPAvgrPKQVKRNVKGSDGMKAEDYEFCSET 160
Cdd:COG5076  77 NDDLENVGGITYSPFEKNRPESLRFDEIVFLAIESVTPESGLGSLLMAHLKT---SVKKRKTPKIEDELLYADNKAIAKF 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078 161 LSDLVKPKHKAYNWPFLEPVDGDLVPGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKFNAPGTEVYVC 240
Cdd:COG5076 154 KKQLFLRDGRFLSSIFLGLPSKREYPDYYEIIKSPMDLLTIQKKLKNGRYKSFEEFVSDLNLMFDNCKLYNGPDSSVYVD 233

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078 241 GQEFEKAVKMHMQKVSPHDIKSRITELKRKVmsYSREIRMLESKlMEQTGEMPTSRAYSLNERVSIGNAILNMSKEQTES 320
Cdd:COG5076 234 AKELEKYFLKLIEEIPEEMLELSIKPGREER--EERESVLITNS-QAHVGAWPFLRPVSDEEVPDYYKDIRDPMDLSTKE 310

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|
gi 19171078 321 VaKIVLKNGAGEfVENDEIEVDMRTIPDHVVEEIDMYIKSINVGEDVRDE 370
Cdd:COG5076 311 L-KLRNNYYRPE-ETFVRDAKLFFDNCVMYNGEVTDYYKNANVLEDFVIK 358
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 16-114 2.03e-52

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 169.38  E-value: 2.03e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078  16 QLKYCSQILTRLKRN---SNAPPFLEPVDPVKLGIPDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNCYTY 92
Cdd:cd05498   1 QLKFCSGILKELFSKkhkAYAWPFYKPVDPEALGLHDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKY 80

                        90       100
                ....*....|....*....|..
gi 19171078  93 NPPGTVVHEMGKGLEAVYTDLM 114
Cdd:cd05498  81 NPPDHPVHAMARKLQDVFEDRW 102
BROMO smart00297
bromo domain;
152-255 4.30e-29

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 108.52  E-value: 4.30e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078    152 EDYEFCSETLSDLVKPKH-KAYNWPFLEPVDGDLVPGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKF 230
Cdd:smart00297   3 KLQKKLQELLKAVLDKLDsHPLSWPFLKPVSRKEAPDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNARTY 82

                           90       100
                   ....*....|....*....|....*
gi 19171078    231 NAPGTEVYVCGQEFEKAVKMHMQKV 255
Cdd:smart00297  83 NGPDSEVYKDAKKLEKFFEKKLREL 107
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 20-104 2.21e-27

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 103.16  E-value: 2.21e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078    20 CSQILTRLKRNSNAPPFLEPVDPVKLgiPDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNCYTYNPPGTVV 99
Cdd:pfam00439   1 CLEILDKLMEHPIAAPFLEPVDPDEY--PDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVI 78


                  ....*
gi 19171078   100 HEMGK 104
Cdd:pfam00439  79 YKAAE 83
 
Name Accession Description Interval E-value
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 1-370 1.52e-75

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 238.17  E-value: 1.52e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078   1 MEGEETNSGNILAEHQLKYcSQILTRLKRNSNAPPFlEPVDPVKLGIPDYPEKIKHPMDLSTIRKKLDSKEYegPEGFDG 80
Cdd:COG5076   1 LEFDEVSYSQLGRPSVLKE-EFGNELLRLVDNDSSP-FPNAPEEEGSKNLFQKQLKRMPKEYITSIVDDREP--GSMANV 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078  81 DMRLMFSNCYTYNPPGTVVHEMGKGLEAVYTDLMAGMPQEIPKKRKKTEMPAvgrPKQVKRNVKGSDGMKAEDYEFCSET 160
Cdd:COG5076  77 NDDLENVGGITYSPFEKNRPESLRFDEIVFLAIESVTPESGLGSLLMAHLKT---SVKKRKTPKIEDELLYADNKAIAKF 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078 161 LSDLVKPKHKAYNWPFLEPVDGDLVPGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKFNAPGTEVYVC 240
Cdd:COG5076 154 KKQLFLRDGRFLSSIFLGLPSKREYPDYYEIIKSPMDLLTIQKKLKNGRYKSFEEFVSDLNLMFDNCKLYNGPDSSVYVD 233

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078 241 GQEFEKAVKMHMQKVSPHDIKSRITELKRKVmsYSREIRMLESKlMEQTGEMPTSRAYSLNERVSIGNAILNMSKEQTES 320
Cdd:COG5076 234 AKELEKYFLKLIEEIPEEMLELSIKPGREER--EERESVLITNS-QAHVGAWPFLRPVSDEEVPDYYKDIRDPMDLSTKE 310

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|
gi 19171078 321 VaKIVLKNGAGEfVENDEIEVDMRTIPDHVVEEIDMYIKSINVGEDVRDE 370
Cdd:COG5076 311 L-KLRNNYYRPE-ETFVRDAKLFFDNCVMYNGEVTDYYKNANVLEDFVIK 358
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 16-114 2.03e-52

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 169.38  E-value: 2.03e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078  16 QLKYCSQILTRLKRN---SNAPPFLEPVDPVKLGIPDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNCYTY 92
Cdd:cd05498   1 QLKFCSGILKELFSKkhkAYAWPFYKPVDPEALGLHDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKY 80

                        90       100
                ....*....|....*....|..
gi 19171078  93 NPPGTVVHEMGKGLEAVYTDLM 114
Cdd:cd05498  81 NPPDHPVHAMARKLQDVFEDRW 102
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
 153-252 1.96e-49

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99931  Cd Length: 102  Bit Score: 161.68  E-value: 1.96e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078 153 DYEFCSETLSDLVKPKHKAYNWPFLEPVD--GDLVPGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKF 230
Cdd:cd05499   1 ELKFCEEVLKELMKPKHSAYNWPFLDPVDpvALNIPNYFSIIKKPMDLGTISKKLQNGQYQSAKEFERDVRLIFKNCYTF 80

                        90       100
                ....*....|....*....|..
gi 19171078 231 NAPGTEVYVCGQEFEKAVKMHM 252
Cdd:cd05499  81 NPEGTDVYMMGHQLEEVFNDKW 102
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 15-110 1.18e-36

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 128.20  E-value: 1.18e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078  15 HQLKYCSQILTRLKRNSNAPPFLEPVDPVKLGIPDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNCYTYNP 94
Cdd:cd05500   4 HQHKFLLSSIRSLKRLKDARPFLVPVDPVKLNIPHYPTIIKKPMDLGTIERKLKSNVYTSVEEFTADFNLMVDNCLTFNG 83

                        90
                ....*....|....*.
gi 19171078  95 PGTVVHEMGKGLEAVY 110
Cdd:cd05500  84 PEHPVSQMGKRLQAAF 99
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
 17-114 3.92e-35

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99931  Cd Length: 102  Bit Score: 124.32  E-value: 3.92e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078  17 LKYCSQILTRL--KRNSN-APPFLEPVDPVKLGIPDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNCYTYN 93
Cdd:cd05499   2 LKFCEEVLKELmkPKHSAyNWPFLDPVDPVALNIPNYFSIIKKPMDLGTISKKLQNGQYQSAKEFERDVRLIFKNCYTFN 81

                        90       100
                ....*....|....*....|.
gi 19171078  94 PPGTVVHEMGKGLEAVYTDLM 114
Cdd:cd05499  82 PEGTDVYMMGHQLEEVFNDKW 102
Bromo_plant1 cd05506
Bromodomain, uncharacterized subfamily specific to plants. Might function as a global ...
 17-106 5.41e-35

Bromodomain, uncharacterized subfamily specific to plants. Might function as a global transcription factor. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99938  Cd Length: 99  Bit Score: 123.98  E-value: 5.41e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078  17 LKYCSQILTRLKRNSNAPPFLEPVDPVKLGIPDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNCYTYNPPG 96
Cdd:cd05506   2 MKQCGTLLRKLMKHKWGWVFNAPVDVVALGLPDYFDIIKKPMDLGTVKKKLEKGEYSSPEEFAADVRLTFANAMRYNPPG 81

                        90
                ....*....|
gi 19171078  97 TVVHEMGKGL 106
Cdd:cd05506  82 NDVHTMAKEL 91
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 152-255 5.71e-35

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 123.82  E-value: 5.71e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078 152 EDYEFCSETLSDLvkpKHKAYNWPFLEPVDGDLVPGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKFN 231
Cdd:cd05509   1 PLYTQLKKVLDSL---KNHKSAWPFLEPVDKEEAPDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYN 77

                        90       100
                ....*....|....*....|....
gi 19171078 232 APGTEVYVCGQEFEKAVKMHMQKV 255
Cdd:cd05509  78 GPDTEYYKCANKLEKFFWKKLKEL 101
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 18-114 6.16e-32

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 115.93  E-value: 6.16e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078  18 KYCSQILTRLKRNSN--APPFLEPVDPvkLGIPDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNCYTYNPP 95
Cdd:cd04369   3 KKLRSLLDALKKLKRdlSEPFLEPVDP--KEAPDYYEVIKNPMDLSTIKKKLKNGEYKSLEEFEADVRLIFSNAKTYNGP 80

                        90
                ....*....|....*....
gi 19171078  96 GTVVHEMGKGLEAVYTDLM 114
Cdd:cd04369  81 GSPIYKDAKKLEKLFEKLL 99
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 156-252 2.87e-31

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 114.30  E-value: 2.87e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078 156 FCSETLSDLVKPKHKAYNWPFLEPVDGDL--VPGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKFNAP 233
Cdd:cd05498   4 FCSGILKELFSKKHKAYAWPFYKPVDPEAlgLHDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKYNPP 83

                        90
                ....*....|....*....
gi 19171078 234 GTEVYVCGQEFEKAVKMHM 252
Cdd:cd05498  84 DHPVHAMARKLQDVFEDRW 102
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 23-117 2.26e-29

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 109.18  E-value: 2.26e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078  23 ILTRLKRNSNAPPFLEPVDpvKLGIPDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNCYTYNPPGTVVHEM 102
Cdd:cd05509   9 VLDSLKNHKSAWPFLEPVD--KEEAPDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYNGPDTEYYKC 86

                        90
                ....*....|....*
gi 19171078 103 GKGLEAVYTDLMAGM 117
Cdd:cd05509  87 ANKLEKFFWKKLKEL 101
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 153-252 2.91e-29

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 108.61  E-value: 2.91e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078 153 DYEFCSETLSDLVKPKHKaYNWPFLEPVDGDLVPGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKFNA 232
Cdd:cd04369   1 LKKKLRSLLDALKKLKRD-LSEPFLEPVDPKEAPDYYEVIKNPMDLSTIKKKLKNGEYKSLEEFEADVRLIFSNAKTYNG 79

                        90       100
                ....*....|....*....|
gi 19171078 233 PGTEVYVCGQEFEKAVKMHM 252
Cdd:cd04369  80 PGSPIYKDAKKLEKLFEKLL 99
BROMO smart00297
bromo domain;
152-255 4.30e-29

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 108.52  E-value: 4.30e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078    152 EDYEFCSETLSDLVKPKH-KAYNWPFLEPVDGDLVPGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKF 230
Cdd:smart00297   3 KLQKKLQELLKAVLDKLDsHPLSWPFLKPVSRKEAPDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNARTY 82

                           90       100
                   ....*....|....*....|....*
gi 19171078    231 NAPGTEVYVCGQEFEKAVKMHMQKV 255
Cdd:smart00297  83 NGPDSEVYKDAKKLEKFFEKKLREL 107
BROMO smart00297
bromo domain;
14-115 9.50e-29

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 107.75  E-value: 9.50e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078     14 EHQLKYCSQIL----TRLKRNSNAPPFLEPVDPVKlgIPDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNC 89
Cdd:smart00297   2 PKLQKKLQELLkavlDKLDSHPLSWPFLKPVSRKE--APDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNA 79

                           90       100
                   ....*....|....*....|....*.
gi 19171078     90 YTYNPPGTVVHEMGKGLEAVYTDLMA 115
Cdd:smart00297  80 RTYNGPDSEVYKDAKKLEKFFEKKLR 105
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 20-104 2.21e-27

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 103.16  E-value: 2.21e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078    20 CSQILTRLKRNSNAPPFLEPVDPVKLgiPDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNCYTYNPPGTVV 99
Cdd:pfam00439   1 CLEILDKLMEHPIAAPFLEPVDPDEY--PDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSVI 78


                  ....*
gi 19171078   100 HEMGK 104
Cdd:pfam00439  79 YKAAE 83
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 16-117 3.35e-27

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99929  Cd Length: 107  Bit Score: 103.66  E-value: 3.35e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078  16 QLKYCSQ-ILTRLKRNSNAPPFLEPVDPVKLGIPDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNCYTYNP 94
Cdd:cd05497   5 QLQYLLKvVLKALWKHKFAWPFQQPVDAVKLNLPDYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTNCYIYNK 84

                        90       100
                ....*....|....*....|...
gi 19171078  95 PGTVVHEMGKGLEAVYTDLMAGM 117
Cdd:cd05497  85 PGDDVVLMAQTLEKLFLQKLAQM 107
Bromo_tif1_like cd05502
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of ...
 17-115 7.92e-26

Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or corepressors to modulate transcription. Vertebrate Tif1-gamma, also labeled E3 ubiquitin-protein ligase TRIM33, plays a role in the control of hematopoiesis. Its homologue in Xenopus laevis, Ectodermin, has been shown to function in germ-layer specification and control of cell growth during embryogenesis. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99934 [Multi-domain]  Cd Length: 109  Bit Score: 100.06  E-value: 7.92e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078  17 LKYCSQILTRLKRNSNAPPFLEPVDPvklGIPDYPEKIKHPMDLSTIRKKLDSKE---YEGPEGFDGDMRLMFSNCYTYN 93
Cdd:cd05502   6 QRKCERLLLELYCHELSLPFHEPVSP---SVPNYYKIIKTPMDLSLIRKKLQPKSpqhYSSPEEFVADVRLMFKNCYKFN 82

                        90       100
                ....*....|....*....|..
gi 19171078  94 PPGTVVHEMGKGLEAVYTDLMA 115
Cdd:cd05502  83 EEDSEVAQAGKELELFFEEQLK 104
Bromo_BAZ2A_B_like cd05503
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B ...
 153-246 2.31e-25

Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting protein 5) and hWALp3. The proteins may play roles in transcriptional regulation. Human Tip5 is part of a complex termed NoRC (nucleolar remodeling complex), which induces nucleosome sliding and may play a role in the regulation of the rDNA locus. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99935  Cd Length: 97  Bit Score: 98.22  E-value: 2.31e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078 153 DYEFCSETLSDLVKpkhKAYNWPFLEPVDGDLVPGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKFNA 232
Cdd:cd05503   1 DLALCETILDEMEA---HEDAWPFLEPVNTKLVPGYRKIIKKPMDFSTIREKLESGQYKTLEEFAEDVRLVFDNCETFNE 77

                        90
                ....*....|....
gi 19171078 233 PGTEVYVCGQEFEK 246
Cdd:cd05503  78 DDSEVGRAGHNMRK 91
Bromo_cbp_like cd05495
Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase ...
 27-114 4.71e-24

Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to phosphorylated CREB protein and augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99927  Cd Length: 108  Bit Score: 95.20  E-value: 4.71e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078  27 LKRNSNAPPFLEPVDPVKLGIPDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNCYTYNPPGTVVHEMGKGL 106
Cdd:cd05495  16 YKQDPESLPFRQPVDPKLLGIPDYFDIVKNPMDLSTIRRKLDTGQYQDPWQYVDDVWLMFDNAWLYNRKTSRVYKYCTKL 95


                ....*...
gi 19171078 107 EAVYTDLM 114
Cdd:cd05495  96 AEVFEQEI 103
Bromo_TFIID cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, ...
 158-235 2.37e-22

Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99943 [Multi-domain]  Cd Length: 112  Bit Score: 90.79  E-value: 2.37e-22
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19171078 158 SETLSDLV-KPKHKAYNWPFLEPVDGDLVPGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKFNAPGT 235
Cdd:cd05511   2 SFILDEIVnELKNLPDSWPFHTPVNKKKVPDYYKIIKRPMDLQTIRKKISKHKYQSREEFLEDIELIVDNSVLYNGPDS 80
Bromo_BAZ2A_B_like cd05503
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B ...
 17-108 4.31e-22

Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting protein 5) and hWALp3. The proteins may play roles in transcriptional regulation. Human Tip5 is part of a complex termed NoRC (nucleolar remodeling complex), which induces nucleosome sliding and may play a role in the regulation of the rDNA locus. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99935  Cd Length: 97  Bit Score: 89.36  E-value: 4.31e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078  17 LKYCSQILTRLKRNSNAPPFLEPVDPvKLgIPDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNCYTYN--- 93
Cdd:cd05503   2 LALCETILDEMEAHEDAWPFLEPVNT-KL-VPGYRKIIKKPMDFSTIREKLESGQYKTLEEFAEDVRLVFDNCETFNedd 79

                        90
                ....*....|....*.
gi 19171078  94 -PPGTVVHEMGKGLEA 108
Cdd:cd05503  80 sEVGRAGHNMRKFFEK 95
Bromo_Acf1_like cd05504
Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was ...
 15-108 1.25e-21

Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) and regulates ISWI-induced nucleosome remodeling. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99936  Cd Length: 115  Bit Score: 88.99  E-value: 1.25e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078  15 HQLKYCSQILTRLKRNSNAPPFLEPVDpvKLGIPDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNCYTYNP 94
Cdd:cd05504  12 LNLSALEQLLVEIVKHKDSWPFLRPVS--KIEVPDYYDIIKKPMDLGTIKEKLNMGEYKLAEEFLSDIQLVFSNCFLYNP 89

                        90
                ....*....|....
gi 19171078  95 PGTVVHEMGKGLEA 108
Cdd:cd05504  90 EHTSVYKAGTRLQR 103
Bromo_plant1 cd05506
Bromodomain, uncharacterized subfamily specific to plants. Might function as a global ...
 168-246 2.38e-21

Bromodomain, uncharacterized subfamily specific to plants. Might function as a global transcription factor. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99938  Cd Length: 99  Bit Score: 87.39  E-value: 2.38e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078 168 KHKaYNWPFLEPVDGDL--VPGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKFNAPGTEVYVCGQE-- 243
Cdd:cd05506  14 KHK-WGWVFNAPVDVVAlgLPDYFDIIKKPMDLGTVKKKLEKGEYSSPEEFAADVRLTFANAMRYNPPGNDVHTMAKEll 92


                ....*
gi 19171078 244 --FEK 246
Cdd:cd05506  93 kiFET 97
Bromo_Acf1_like cd05504
Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was ...
 157-257 2.58e-21

Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) and regulates ISWI-induced nucleosome remodeling. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99936  Cd Length: 115  Bit Score: 87.84  E-value: 2.58e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078 157 CSETLSDLVKpkHKAyNWPFLEPVDGDLVPGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKFNAPGTE 236
Cdd:cd05504  17 LEQLLVEIVK--HKD-SWPFLRPVSKIEVPDYYDIIKKPMDLGTIKEKLNMGEYKLAEEFLSDIQLVFSNCFLYNPEHTS 93

                        90       100
                ....*....|....*....|.
gi 19171078 237 VYVCGQEFEKAVKMHMQKVSP 257
Cdd:cd05504  94 VYKAGTRLQRFFIKRCRKLGL 114
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 157-243 6.11e-21

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 85.83  E-value: 6.11e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078   157 CSETLSDLVKpkHKAYNWpFLEPVDGDLVPGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKFNAPGTE 236
Cdd:pfam00439   1 CLEILDKLME--HPIAAP-FLEPVDPDEYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSV 77


                  ....*..
gi 19171078   237 VYVCGQE 243
Cdd:pfam00439  78 IYKAAEK 84
Bromo_WSTF_like cd05505
Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The ...
 153-247 3.12e-19

Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two chromatin remodeling complexes, WINAC and WICH. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99937  Cd Length: 97  Bit Score: 81.81  E-value: 3.12e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078 153 DYEFCSETLSDLVKPKHkayNWPFLEPVDGDLVPGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKFNA 232
Cdd:cd05505   1 ELQKCEEILSKILKYRF---SWPFREPVTADEAEDYKKVITNPMDLQTMQTKCSCGSYSSVQEFLDDMKLVFSNAEKYYE 77

                        90
                ....*....|....*
gi 19171078 233 PGTEVYVCGQEFEKA 247
Cdd:cd05505  78 NGSYVLSCMRKTEQC 92
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 149-252 1.61e-18

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 80.05  E-value: 1.61e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078 149 MKAEDYEFCSETLSDLvKPKHKAYnwPFLEPVDGDL--VPGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVEN 226
Cdd:cd05500   1 MTKHQHKFLLSSIRSL-KRLKDAR--PFLVPVDPVKlnIPHYPTIIKKPMDLGTIERKLKSNVYTSVEEFTADFNLMVDN 77

                        90       100
                ....*....|....*....|....*.
gi 19171078 227 CKKFNAPGTEVYVCGQEFEKAVKMHM 252
Cdd:cd05500  78 CLTFNGPEHPVSQMGKRLQAAFEKHL 103
Bromo_brd1_like cd05512
Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein ...
 176-253 3.38e-18

Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99944  Cd Length: 98  Bit Score: 78.98  E-value: 3.38e-18
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19171078 176 FLEPVDGDLVPGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKFNAPGTEVYvcgqefEKAVKMHMQ 253
Cdd:cd05512  22 FSEPVDLSEVPDYLDHIKQPMDFSTMRKKLESQRYRTLEDFEADFNLIINNCLAYNAKDTIFY------RAAVRLRDQ 93
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 168-257 4.47e-17

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99929  Cd Length: 107  Bit Score: 75.92  E-value: 4.47e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078 168 KHKaYNWPFLEPVDGDL--VPGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKFNAPGTEVYVCGQEFE 245
Cdd:cd05497  19 KHK-FAWPFQQPVDAVKlnLPDYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTNCYIYNKPGDDVVLMAQTLE 97

                        90
                ....*....|..
gi 19171078 246 KAVkmhMQKVSP 257
Cdd:cd05497  98 KLF---LQKLAQ 106
Bromo_SPT7_like cd05510
Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the ...
 152-256 4.79e-17

Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, and SLIK. SAGA is involved in the RNA polymerase II-dependent transcriptional regulation of about 10% of all yeast genes. The SPT7 bromodomain has been shown to weakly interact with acetylated histone H3, but not H4. The human representative of this subfamily is cat eye syndrome critical region protein 2 (CECR2). Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99942 [Multi-domain]  Cd Length: 112  Bit Score: 76.33  E-value: 4.79e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078 152 EDYEFCSETLSDLvkPKHKAYNWPFLEPVDGDLVPGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKFN 231
Cdd:cd05510   7 EFYESLDKVLNEL--KTYTEHSTPFLTKVSKREAPDYYDIIKKPMDLGTMLKKLKNLQYKSKAEFVDDLNLIWKNCLLYN 84

                        90       100
                ....*....|....*....|....*.
gi 19171078 232 APGTEVYV-CGQEFEKAVKMHMQKVS 256
Cdd:cd05510  85 SDPSHPLRrHANFMKKKAEHLLKLIP 110
Bromo_tif1_like cd05502
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of ...
 175-257 6.31e-17

Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or corepressors to modulate transcription. Vertebrate Tif1-gamma, also labeled E3 ubiquitin-protein ligase TRIM33, plays a role in the control of hematopoiesis. Its homologue in Xenopus laevis, Ectodermin, has been shown to function in germ-layer specification and control of cell growth during embryogenesis. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99934 [Multi-domain]  Cd Length: 109  Bit Score: 75.79  E-value: 6.31e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078 175 PFLEPVdGDLVPGYYSVIKEPMDLQTMRSKLEQRR---YQSVEEFGRDLELIVENCKKFNAPGTEVYVCGQEFEKAVKMH 251
Cdd:cd05502  24 PFHEPV-SPSVPNYYKIIKTPMDLSLIRKKLQPKSpqhYSSPEEFVADVRLMFKNCYKFNEEDSEVAQAGKELELFFEEQ 102


                ....*.
gi 19171078 252 MQKVSP 257
Cdd:cd05502 103 LKEILP 108
Bromo_WDR9_II cd05496
Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 18-94 9.00e-17

Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99928  Cd Length: 119  Bit Score: 75.57  E-value: 9.00e-17
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19171078  18 KYCSQILTRLKRNSNAPPFLEPVDPVKLgiPDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNCYTYNP 94
Cdd:cd05496   8 KQCKELVNLMWDCEDSEPFRQPVDLLKY--PDYRDIIDTPMDLGTVKETLFGGNYDDPMEFAKDVRLIFSNSKSYTP 82
Bromo_brd7_like cd05513
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown ...
 176-238 9.36e-17

Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99945  Cd Length: 98  Bit Score: 74.75  E-value: 9.36e-17
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19171078 176 FLEPVDGDLVPGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKFNAPGTEVY 238
Cdd:cd05513  22 FAFPVTDFIAPGYSSIIKHPMDFSTMKEKIKNNDYQSIEEFKDDFKLMCENAMKYNKPDTIYY 84
Bromo_TFIID cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, ...
 21-120 9.86e-17

Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99943 [Multi-domain]  Cd Length: 112  Bit Score: 75.38  E-value: 9.86e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078  21 SQILTRLKRNSNAPPFLEPVDPVKlgIPDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNCYTYNPPGTVVH 100
Cdd:cd05511   6 DEIVNELKNLPDSWPFHTPVNKKK--VPDYYKIIKRPMDLQTIRKKISKHKYQSREEFLEDIELIVDNSVLYNGPDSVYT 83

                        90       100
                ....*....|....*....|
gi 19171078 101 EMGKGLEAVYTDLMAGMPQE 120
Cdd:cd05511  84 KKAKEMLELAEELLAEREEK 103
Bromo_SPT7_like cd05510
Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the ...
 9-118 1.44e-16

Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, and SLIK. SAGA is involved in the RNA polymerase II-dependent transcriptional regulation of about 10% of all yeast genes. The SPT7 bromodomain has been shown to weakly interact with acetylated histone H3, but not H4. The human representative of this subfamily is cat eye syndrome critical region protein 2 (CECR2). Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99942 [Multi-domain]  Cd Length: 112  Bit Score: 74.79  E-value: 1.44e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078   9 GNILAEHQLKYCSQILTRLKRNS-NAPPFLEPVDPVKlgIPDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFS 87
Cdd:cd05510   1 ERIGQEEFYESLDKVLNELKTYTeHSTPFLTKVSKRE--APDYYDIIKKPMDLGTMLKKLKNLQYKSKAEFVDDLNLIWK 78

                        90       100       110
                ....*....|....*....|....*....|..
gi 19171078  88 NCYTYNP-PGTVVHEMGKGLEAVYTDLMAGMP 118
Cdd:cd05510  79 NCLLYNSdPSHPLRRHANFMKKKAEHLLKLIP 110
Bromo_brd1_like cd05512
Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein ...
 36-103 7.40e-15

Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99944  Cd Length: 98  Bit Score: 69.74  E-value: 7.40e-15
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19171078  36 FLEPVDPVKlgIPDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNCYTYNPPGTVVHEMG 103
Cdd:cd05512  22 FSEPVDLSE--VPDYLDHIKQPMDFSTMRKKLESQRYRTLEDFEADFNLIINNCLAYNAKDTIFYRAA 87
Bromo_AAA cd05528
Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long ...
 175-231 1.47e-14

Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this alignment is an uncharacterized protein predicted from analysis of cDNA clones from human fetal liver


Pssm-ID: 99957  Cd Length: 112  Bit Score: 69.31  E-value: 1.47e-14
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 19171078 175 PFLEPVDGDLVPGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKFN 231
Cdd:cd05528  23 AFTKPVDEEEVPDYYEIIKQPMDLQTILQKLDTHQYLTAKDFLKDIDLIVTNALEYN 79
Bromo_Rsc1_2_II cd05522
Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 186-246 1.51e-14

Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99953 [Multi-domain]  Cd Length: 104  Bit Score: 68.81  E-value: 1.51e-14
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19171078 186 PGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKFNAPGTEVYVCGQEFEK 246
Cdd:cd05522  38 PEYYQEISNPISLDDIKKKVKRRKYKSFDQFLNDLNLMFENAKLYNENDSQEYKDAVLLEK 98
Bromo_polybromo_III cd05520
Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which ...
 29-101 2.14e-14

Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99951  Cd Length: 103  Bit Score: 68.52  E-value: 2.14e-14
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19171078  29 RNSNAPPFLEPVD--PVKLGIPDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNCYTYNPPGTVVHE 101
Cdd:cd05520  16 RNNQGQLLAEPFLklPSKRKYPDYYQEIKNPISLQQIRTKLKNGEYETLEELEADLNLMFENAKRYNVPNSRIYK 90
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 24-114 3.83e-14

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99958  Cd Length: 128  Bit Score: 68.52  E-value: 3.83e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078  24 LTRLKRNSNAPPFLEPVDpVKLGIPDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNCYTYNPPGTVVHEMG 103
Cdd:cd05529  36 LLLSLQLEIAEYFEYPVD-LRAWYPDYWNRVPVPMDLETIRSRLENRYYRSLEALRHDVRLILSNAETFNEPNSEIAKKA 114

                        90
                ....*....|.
gi 19171078 104 KGLEAVYTDLM 114
Cdd:cd05529 115 KRLSDWLLRIL 125
Bromo_AAA cd05528
Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long ...
 16-94 1.70e-13

Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this alignment is an uncharacterized protein predicted from analysis of cDNA clones from human fetal liver


Pssm-ID: 99957  Cd Length: 112  Bit Score: 66.23  E-value: 1.70e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078  16 QLKYC-SQILTRLKRNSNAPPFLEPVDPVKlgIPDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNCYTYNP 94
Cdd:cd05528   3 ELRLFlRDVLKRLASDKRFNAFTKPVDEEE--VPDYYEIIKQPMDLQTILQKLDTHQYLTAKDFLKDIDLIVTNALEYNP 80
Bromo_polybromo_V cd05515
Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which ...
 186-238 1.91e-13

Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99946  Cd Length: 105  Bit Score: 65.79  E-value: 1.91e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 19171078 186 PGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKFNAPGTEVY 238
Cdd:cd05515  37 PDYYDVIKKPIDMEKIRSKIEGNQYQSLDDMVSDFVLMFDNACKYNEPDSQIY 89
Bromo_polybromo_III cd05520
Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which ...
 175-254 1.40e-12

Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99951  Cd Length: 103  Bit Score: 63.51  E-value: 1.40e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078 175 PFLEPVDGDLVPGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKFNAPGTEVYVCgqefekAVKM--HM 252
Cdd:cd05520  26 PFLKLPSKRKYPDYYQEIKNPISLQQIRTKLKNGEYETLEELEADLNLMFENAKRYNVPNSRIYKD------AEKLqkLM 99


                ..
gi 19171078 253 QK 254
Cdd:cd05520 100 QA 101
Bromo_WSTF_like cd05505
Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The ...
 16-99 2.36e-12

Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two chromatin remodeling complexes, WINAC and WICH. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99937  Cd Length: 97  Bit Score: 62.55  E-value: 2.36e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078  16 QLKYCSQILTRLKRNSNAPPFLEPvdPVKLGIPDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNCYTYNPP 95
Cdd:cd05505   1 ELQKCEEILSKILKYRFSWPFREP--VTADEAEDYKKVITNPMDLQTMQTKCSCGSYSSVQEFLDDMKLVFSNAEKYYEN 78


                ....
gi 19171078  96 GTVV 99
Cdd:cd05505  79 GSYV 82
Bromo_polybromo_IV cd05518
Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which ...
 40-112 9.86e-12

Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99949 [Multi-domain]  Cd Length: 103  Bit Score: 60.92  E-value: 9.86e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19171078  40 VDPVKLGIPDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNCYTYNPPGTVVHEMGKGLEAVYTD 112
Cdd:cd05518  29 EKPSKKDYPDYYKIILEPIDLKTIEHNIRNDKYATEEELMDDFKLMFRNARHYNEEGSQVYEDANILEKVLKE 101
Bromo_polybromo_II cd05517
Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which ...
 183-238 1.54e-11

Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99948  Cd Length: 103  Bit Score: 60.53  E-value: 1.54e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 19171078 183 DLVPGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKFNAPGTEVY 238
Cdd:cd05517  34 VLYPDYYAVIKEPIDLKTIAQRIQSGYYKSIEDMEKDLDLMVKNAKTFNEPGSQVY 89
Bromo_SNF2 cd05519
Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in ...
 176-249 1.82e-11

Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in transcriptional activation, it is the catalytic component of the SWI/SNF ATP-dependent chromatin remodeling complex. The protein is essential for the regulation of gene expression (both positive and negative) of a large number of genes. The SWI/SNF complex changes chromatin structure by altering DNA-histone contacts within the nucleosome, which results in a re-positioning of the nucleosome and facilitates or represses the binding of gene-specific transcription factors. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99950  Cd Length: 103  Bit Score: 60.05  E-value: 1.82e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19171078 176 FLEPVDGDLVPGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKFNAPGTEVYVCGQEFEKAVK 249
Cdd:cd05519  27 FLEKPSKKLYPDYYVIIKRPIALDQIKRRIEGRAYKSLEEFLEDFHLMFANARTYNQEGSIVYEDAVEMEKAFK 100
Bromo_SNF2L2 cd05516
Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI ...
 175-255 2.04e-11

Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone receptors to boost transcriptional activation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99947  Cd Length: 107  Bit Score: 60.13  E-value: 2.04e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078 175 PFLE-PVDGDLvPGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKFNAPGTEVYVCGQEFEKAVKMHMQ 253
Cdd:cd05516  27 VFIQlPSRKEL-PEYYELIRKPVDFKKIKERIRNHKYRSLEDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFKSARQ 105


                ..
gi 19171078 254 KV 255
Cdd:cd05516 106 KI 107
Bromo_brd7_like cd05513
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown ...
 48-106 2.13e-11

Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99945  Cd Length: 98  Bit Score: 59.73  E-value: 2.13e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 19171078  48 PDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNCYTYNPPGTVVHEMGKGL 106
Cdd:cd05513  32 PGYSSIIKHPMDFSTMKEKIKNNDYQSIEEFKDDFKLMCENAMKYNKPDTIYYKAAKKL 90
Bromo_brd8_like cd05507
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with ...
 23-121 2.64e-11

Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be a nuclear receptor coactivator. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99939  Cd Length: 104  Bit Score: 59.69  E-value: 2.64e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078  23 ILTRLKRNSNAPPFLEPVDpvKLGIPDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNCYTYNPPGTVVHEM 102
Cdd:cd05507  11 VYRTLASHRYASVFLKPVT--EDIAPGYHSVVYRPMDLSTIKKNIENGTIRSTAEFQRDVLLMFQNAIMYNSSDHDVYLM 88

                        90
                ....*....|....*....
gi 19171078 103 GKgleAVYTDLMAGMPQEI 121
Cdd:cd05507  89 AV---EMQREVMSQIQQLL 104
Bromo_cbp_like cd05495
Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase ...
 175-238 4.07e-11

Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to phosphorylated CREB protein and augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99927  Cd Length: 108  Bit Score: 59.38  E-value: 4.07e-11
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19171078 175 PFLEPVDGDL--VPGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKFNAPGTEVY 238
Cdd:cd05495  24 PFRQPVDPKLlgIPDYFDIVKNPMDLSTIRRKLDTGQYQDPWQYVDDVWLMFDNAWLYNRKTSRVY 89
Bromo_brd8_like cd05507
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with ...
 169-253 6.74e-11

Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be a nuclear receptor coactivator. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99939  Cd Length: 104  Bit Score: 58.53  E-value: 6.74e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078 169 HKaYNWPFLEPVDGDLVPGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKFNAPGTEVYVCGQEFEKAV 248
Cdd:cd05507  18 HR-YASVFLKPVTEDIAPGYHSVVYRPMDLSTIKKNIENGTIRSTAEFQRDVLLMFQNAIMYNSSDHDVYLMAVEMQREV 96


                ....*
gi 19171078 249 KMHMQ 253
Cdd:cd05507  97 MSQIQ 101
Bromo_polybromo_V cd05515
Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which ...
 42-100 1.40e-10

Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99946  Cd Length: 105  Bit Score: 57.70  E-value: 1.40e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 19171078  42 PVKLGIPDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNCYTYNPPGTVVH 100
Cdd:cd05515  31 PSKSEYPDYYDVIKKPIDMEKIRSKIEGNQYQSLDDMVSDFVLMFDNACKYNEPDSQIY 89
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 164-237 2.41e-10

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99958  Cd Length: 128  Bit Score: 57.73  E-value: 2.41e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19171078 164 LVKPKHKAYNWPFLEPVD-GDLVPGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKFNAPGTEV 237
Cdd:cd05529  36 LLLSLQLEIAEYFEYPVDlRAWYPDYWNRVPVPMDLETIRSRLENRYYRSLEALRHDVRLILSNAETFNEPNSEI 110
Bromo_SNF2 cd05519
Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in ...
 36-112 2.96e-10

Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in transcriptional activation, it is the catalytic component of the SWI/SNF ATP-dependent chromatin remodeling complex. The protein is essential for the regulation of gene expression (both positive and negative) of a large number of genes. The SWI/SNF complex changes chromatin structure by altering DNA-histone contacts within the nucleosome, which results in a re-positioning of the nucleosome and facilitates or represses the binding of gene-specific transcription factors. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99950  Cd Length: 103  Bit Score: 56.96  E-value: 2.96e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19171078  36 FLEPvdPVKLGIPDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNCYTYNPPGTVVHEMGKGLEAVYTD 112
Cdd:cd05519  27 FLEK--PSKKLYPDYYVIIKRPIALDQIKRRIEGRAYKSLEEFLEDFHLMFANARTYNQEGSIVYEDAVEMEKAFKK 101
Bromo_polybromo_IV cd05518
Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which ...
 164-249 4.03e-10

Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99949 [Multi-domain]  Cd Length: 103  Bit Score: 56.30  E-value: 4.03e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078 164 LVKPKHKAYnwpflepvdgdlvPGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKFNAPGTEVYVCGQE 243
Cdd:cd05518  28 MEKPSKKDY-------------PDYYKIILEPIDLKTIEHNIRNDKYATEEELMDDFKLMFRNARHYNEEGSQVYEDANI 94


                ....*.
gi 19171078 244 FEKAVK 249
Cdd:cd05518  95 LEKVLK 100
Bromo_WDR9_II cd05496
Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 175-231 6.67e-10

Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99928  Cd Length: 119  Bit Score: 56.31  E-value: 6.67e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 19171078 175 PFLEPVDGDLVPGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKFN 231
Cdd:cd05496  25 PFRQPVDLLKYPDYRDIIDTPMDLGTVKETLFGGNYDDPMEFAKDVRLIFSNSKSYT 81
Bromo_ASH1 cd05525
Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the ...
 42-93 1.04e-09

Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in histones H3 and H4. Mammalian ASH1 has been shown to methylate histone H3. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99955 [Multi-domain]  Cd Length: 106  Bit Score: 55.47  E-value: 1.04e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 19171078  42 PVKLGIPDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNCYTYN 93
Cdd:cd05525  33 PSKKKNPDYYERITDPVDLSTIEKQILTGYYKTPEAFDSDMLKVFRNAEKYY 84
Bromo_SNF2L2 cd05516
Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI ...
 33-114 6.95e-09

Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone receptors to boost transcriptional activation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99947  Cd Length: 107  Bit Score: 53.20  E-value: 6.95e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078  33 APPFLEPvdPVKLGIPDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNCYTYNPPGTVVHEMGKGLEAVYTD 112
Cdd:cd05516  25 AEVFIQL--PSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLEDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFKS 102


                ..
gi 19171078 113 LM 114
Cdd:cd05516 103 AR 104
Bromodomain_1 cd05494
Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated ...
 17-65 1.63e-08

Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99926 [Multi-domain]  Cd Length: 114  Bit Score: 52.06  E-value: 1.63e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 19171078  17 LKYCSQILTRLKRNSNAPPFLEPVDPVKLGIPDYPEKIKHPMDLSTIRK 65
Cdd:cd05494   5 LERVLRELKRHRRNEDAWPFLEPVNPPRRGAPDYRDVIKRPMSFGTKVN 53
Bromo_polybromo_I cd05524
Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which ...
 186-238 2.39e-08

Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99954 [Multi-domain]  Cd Length: 113  Bit Score: 51.57  E-value: 2.39e-08
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 19171078 186 PGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKFNAPGTEVY 238
Cdd:cd05524  39 PEYYEVVSNPIDLLKIQQKLKTEEYDDVDDLTADFELLINNAKAYYKPDSPEH 91
Bromo_SP100C_like cd05501
Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major ...
 188-251 5.65e-08

Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin level. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99933  Cd Length: 102  Bit Score: 50.12  E-value: 5.65e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19171078 188 YYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKFNAPGTEVYV---CGQEFEKAVKMH 251
Cdd:cd05501  33 YCQGIKEPMWLNKVKERLNERVYHTVEGFVRDMRLIFHNHKLFYKDDDFGQVgitLEKKFEKNFKEV 99
Bromo_Rsc1_2_II cd05522
Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 48-113 8.19e-08

Bromodomain, repeat II in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99953 [Multi-domain]  Cd Length: 104  Bit Score: 49.93  E-value: 8.19e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19171078  48 PDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNCYTYNPPGTVVHEMGKGLEAVYTDL 113
Cdd:cd05522  38 PEYYQEISNPISLDDIKKKVKRRKYKSFDQFLNDLNLMFENAKLYNENDSQEYKDAVLLEKEARLL 103
Bromo_SP100C_like cd05501
Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major ...
 47-93 3.05e-07

Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin level. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99933  Cd Length: 102  Bit Score: 48.19  E-value: 3.05e-07
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 19171078  47 IPDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNCYTYN 93
Cdd:cd05501  30 IRDYCQGIKEPMWLNKVKERLNERVYHTVEGFVRDMRLIFHNHKLFY 76
Bromo_polybromo_I cd05524
Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which ...
 48-100 3.23e-07

Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99954 [Multi-domain]  Cd Length: 113  Bit Score: 48.48  E-value: 3.23e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 19171078  48 PDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNCYTYNPPGTVVH 100
Cdd:cd05524  39 PEYYEVVSNPIDLLKIQQKLKTEEYDDVDDLTADFELLINNAKAYYKPDSPEH 91
Bromo_Rsc1_2_I cd05521
Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 186-249 4.03e-07

Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99952  Cd Length: 106  Bit Score: 48.09  E-value: 4.03e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19171078 186 PGYYSVIKEPMDLQTMRSKLeqRRYQSVEEFGRDLELIVENCKKFNAPGTEVYVCGQEFEKAVK 249
Cdd:cd05521  38 PDYYKIIKNPLSLNTVKKRL--PHYTNAQEFVNDLAQIPWNARLYNTKGSVIYKYALILEKYIN 99
Bromo_polybromo_II cd05517
Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which ...
 42-111 5.44e-07

Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99948  Cd Length: 103  Bit Score: 47.43  E-value: 5.44e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078  42 PVKLGIPDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNCYTYNPPGTVVHEMGKGLEAVYT 111
Cdd:cd05517  31 PSKVLYPDYYAVIKEPIDLKTIAQRIQSGYYKSIEDMEKDLDLMVKNAKTFNEPGSQVYKDANAIKKIFT 100
Bromo_RACK7 cd05508
Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) ...
 24-106 6.04e-07

Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular proliferation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99940  Cd Length: 99  Bit Score: 47.38  E-value: 6.04e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19171078  24 LTRLKRNSNAPpFLEPVDPVKLgiPDYPEKIKHPMDLSTIRKKLDSKEYEGPEGFDGDMRLMFSNCYTYNPPGTVVHEMG 103
Cdd:cd05508  12 LERMKQPGAEP-FLKPVDLEQF--PDYAQYVFKPMDLSTLEKNVRKKAYGSTDAFLADAKWILHNAIIYNGGDHKLTQAA 88


                ...
gi 19171078 104 KGL 106
Cdd:cd05508  89 KAI 91
Bromo_RACK7 cd05508
Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) ...
 175-243 6.92e-07

Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular proliferation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99940  Cd Length: 99  Bit Score: 46.99  E-value: 6.92e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19171078 175 PFLEPVDGDLVPGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKFNAPGTE--------VYVCGQE 243
Cdd:cd05508  22 PFLKPVDLEQFPDYAQYVFKPMDLSTLEKNVRKKAYGSTDAFLADAKWILHNAIIYNGGDHKltqaakaiVKICEQE 98
BET pfam17035
Bromodomain extra-terminal - transcription regulation; The BET, or bromodomain extra-terminal ...
 298-360 2.53e-06

Bromodomain extra-terminal - transcription regulation; The BET, or bromodomain extra-terminal domain, is found on bromodomain proteins that play key roles in development, cancer progression and virus-host pathogenesis. It interacts with NSD3, JMJD6, CHD4, GLTSCR1, and ATAD5 all of which are shown to impart a pTEFb-independent transcriptional activation function on the bromodomain proteins.


Pssm-ID: 435704  Cd Length: 64  Bit Score: 44.41  E-value: 2.53e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19171078   298 YSLNERVSIGNAILNMSKEQTESVAKIVLKNGAGEFVENDEIEVDMRTIPDHVVEEIDMYIKS 360
Cdd:pfam17035   2 MTYEEKRELSERINKLPGEKLGRVIEIIKERNPELQSDDDEIELDIDALDDDTLRKLYNFVKK 64
Bromodomain_1 cd05494
Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated ...
 153-207 5.15e-06

Bromodomain; uncharacterized subfamily. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99926 [Multi-domain]  Cd Length: 114  Bit Score: 45.13  E-value: 5.15e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 19171078 153 DYEFCSETLSDLVKPKHKAYNWPFLEPVDGDL--VPGYYSVIKEPMDLQTMRSKLEQ 207
Cdd:cd05494   1 DYEALERVLRELKRHRRNEDAWPFLEPVNPPRrgAPDYRDVIKRPMSFGTKVNNIVE 57
Bromo_Rsc1_2_I cd05521
Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 42-100 1.16e-04

Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99952  Cd Length: 106  Bit Score: 40.77  E-value: 1.16e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 19171078  42 PVKLGIPDYPEKIKHPMDLSTIRKKLdsKEYEGPEGFDGDMRLMFSNCYTYNPPGTVVH 100
Cdd:cd05521  32 PLRKDYPDYYKIIKNPLSLNTVKKRL--PHYTNAQEFVNDLAQIPWNARLYNTKGSVIY 88
Bromo_ASH1 cd05525
Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the ...
 185-231 1.60e-03

Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in histones H3 and H4. Mammalian ASH1 has been shown to methylate histone H3. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99955 [Multi-domain]  Cd Length: 106  Bit Score: 37.75  E-value: 1.60e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 19171078 185 VPGYYSVIKEPMDLQTMRSKLEQRRYQSVEEFGRDLELIVENCKKFN 231
Cdd:cd05525  38 NPDYYERITDPVDLSTIEKQILTGYYKTPEAFDSDMLKVFRNAEKYY 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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