|
Name |
Accession |
Description |
Interval |
E-value |
| cas_Csn1 |
TIGR01865 |
CRISPR subtype II/NMENI RNA-guided endonuclease Cas9/Csn1; CRISPR loci appear to be mobile ... |
4-1050 |
0e+00 |
|
CRISPR subtype II/NMENI RNA-guided endonuclease Cas9/Csn1; CRISPR loci appear to be mobile elements with a wide host range. This model represents a protein found only in CRISPR-containing species, near other CRISPR-associated proteins (cas), as part of the NMENI subtype of CRISPR/Cas locus. The species range so far for this protein is animal pathogens and commensals only.
:
Pssm-ID: 273840 Cd Length: 805 Bit Score: 908.73 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 4 KYSIGLAIGTNSVGWAVITDEYKVPSKKFKVLGNtdrhsiKKNLIGALLFDSGETAE-ATRLKRTARRRYTRRKNRICYL 82
Cdd:TIGR01865 1 EYILGLDIGIASVGWAIVEDDYKVPAAKRLIDGG------VRNFTGAELPKTGETAAlDRRLARGARRRIRRRKHRLLRL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 83 QEIFSNEMAKVDDSFFHRLEESFLVEEDKKHerhpifgnivdevayhekypTIYHLRKKLVDSTDKADLrlIYLALAHMI 162
Cdd:TIGR01865 75 QELFSREGSLTDFDFFSRLENSFLVEEDKRN--------------------TIYHLRKAALENKLKPDE--LYLALLHII 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 163 KFRGHFLIEgdlnpdnsdvdklfiqlvqtynqlfeenpinasgvdakailsarlsksrrlenliaqlpgekknglfgnli 242
Cdd:TIGR01865 133 KHRGHFLIE----------------------------------------------------------------------- 141
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 243 alslgltpnfksnfdlaedaklqlskdtyDDDLDnllaqigdqyadlflaaknlsdaillsdilrVNTEITKAPLSASMI 322
Cdd:TIGR01865 142 -----------------------------GNDFD-------------------------------TANKETGALLSAVMI 161
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 323 KRYDEHHQDLTLLKALVRQQLPEKYKEIFFDqskngyagyidggasqeefykfikpilekmdgteellvklnreDLLRKQ 402
Cdd:TIGR01865 162 NRYLEHEADLRTLKELILKKFPKKYKEIFSE-------------------------------------------TFLRNQ 198
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 403 RTFDNGSIPHQIHLGELHAILRRQEDFYPFlkdnrekiEKILTFRIPYYVGPLARGNSRFAwmtrkseetitpwnfeeVV 482
Cdd:TIGR01865 199 RGFYNGSIPRQLLLEELEAIFRKQREYYPF--------IKLLTFRIPYYIGPLAEGKSEFA-----------------FV 253
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 483 DKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVTEGMRKPAFLSGEQKKAIVDLLFKTNRKVTVK 562
Cdd:TIGR01865 254 DKPASAENFIEKMTGKCTYLPEEKRAPKHSLLAEKFTVLNELNNVRIIILEQGETKILSKEEKQELLDLLFKKKKLTYKK 333
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 563 QLKEDYFKKIECFDSVEISGVEDR---FNASLGTYHDLLKIIKDKDFLDNEENEDILEDIVLTLTLFEDREMIEERLKTY 639
Cdd:TIGR01865 334 LRKLLGLSEDAIFKGLRYEGLDNAekaFNISLKTYHKLRKALGDKDLLDNPKNPKDLDEIVKILTLYKDREMIKKRLELY 413
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 640 AHLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQSGKTILDFLKSDGFANRNFMQLIHDDSLTFKEDIQKAqvsgqgds 719
Cdd:TIGR01865 414 KDVLNEEQVKKLVRLHFTGWGRLSLKALRGIRPLMEQGKRYDEAILELGGNRNFMQNINDSQLLPKINITKA-------- 485
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 720 lhehiANLAGSPAIKKGILQTVKVVDELVKVMGrhKPENIVIEMARENQTTQKGQKNSRERMKRIEEGIKELGS----QI 795
Cdd:TIGR01865 486 -----KDEILNPVVKRALLQARKVVNELVKKYG--PPDKIVIEMAREEQGTNFGKRNSKERYKKNEDKIKEFASalgkEI 558
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 796 LKEHPVENTQLQNEKLYLYYLQNGRDMYVDQELDINRL---SDYDVAAIVPQSFLKDDSIDNKVLTRSDKARGKSDNVPS 872
Cdd:TIGR01865 559 LKEEPTENSSKNILKLRLYYQQNGKCMYTGKEIDIDDLfdlSYYEIDHILPQSRSFDDSISNKVLVLASENQEKGDQTPY 638
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 873 E-EVVKKMKNYWRQLLNAKLITQRKFDNLTKAERGGLSELDKAGFIKRQLVETRQITKHVAQILDSRMNTKYDendklIR 951
Cdd:TIGR01865 639 EaEIVKKDSAFWNKFEAYVLISKRKSDKLTRAERGGLSDDDKAGFIDRNLNDTRYITRVVANYLKDRFNFHLK-----KR 713
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 952 EVKVITLKSKLVSDFRKDFQFYKVREINNYHHAHDAYLNAVVGTALIKKYPKLESEFVYGDYKVYDVRKMIAkseqeigK 1031
Cdd:TIGR01865 714 KVKVVTLKGQLTSQLRKKWGLYKKREINNYHHAHDAYINAVSTNALVKKFSQLEPEFRYKEYHNFDGRKKKK-------S 786
|
1050
....*....|....*....
gi 1916744588 1032 ATAKYFFYSNIMNFFKTEI 1050
Cdd:TIGR01865 787 ATDKKVKFSNPMEFFKQKV 805
|
|
| Herpes_TAF50 super family |
cl25754 |
Herpesvirus transcription activation factor (transactivator); This family includes EBV BRLF1 ... |
1719-1889 |
1.81e-70 |
|
Herpesvirus transcription activation factor (transactivator); This family includes EBV BRLF1 and similar ORF 50 proteins from other herpesviruses.
The actual alignment was detected with superfamily member pfam03326:
Pssm-ID: 308764 [Multi-domain] Cd Length: 568 Bit Score: 248.46 E-value: 1.81e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1719 GSRDSREGMFLPKPEAGSAISDVFEGREVCQPKRIRPFHPPGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDP 1798
Cdd:pfam03326 390 GLRDSRSTSFLTAPEATSAISDVFQGTEVCQPKRIRALHPPGSPSANRPLPSSLAPTPTGPVHEPGSSLTPATVPQPLDA 469
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1799 APAVTPEASHLLEDPDEETSQavkalremadtviPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPE 1878
Cdd:pfam03326 470 APVATPEASHELQPPDEETPQ-------------PLDEDQALCGQQDASHPPPRGQLDELTTTLESMTEDLNLDSPLSPE 536
|
170
....*....|.
gi 1916744588 1879 LNEILDTFLND 1889
Cdd:pfam03326 537 DNEILETILND 547
|
|
| Cas9_PI super family |
cl24973 |
PAM-interacting domain of CRISPR-associated endonuclease Cas9; Cas9_PI is a family found at ... |
1102-1358 |
1.77e-48 |
|
PAM-interacting domain of CRISPR-associated endonuclease Cas9; Cas9_PI is a family found at the C-terminal of bacterial type II CRISPR system Cas9 endonuclease. This domain adopts a novel protein fold that is unique to the Cas9 family. It is positioned in the structure-DNA-complex to recognize the PAM sequence on the non-complementary DNA strand of the crRNA. PAM sequence is protospacer-adjacent motifs on DNA. See family CRISPR-DR2, Rfam:RF01315. Cas9 carries two nuclease domains, HNH and RuvC, which cleave the DNA strands that are complementary and non-complementary to the 20 nucleotide guide sequence in crRNAs, respectively.
The actual alignment was detected with superfamily member pfam16595:
Pssm-ID: 435449 Cd Length: 264 Bit Score: 174.43 E-value: 1.77e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1102 TGGFSKESILP--KRNSDKLIARKKD---WDPKKYGGFDSPTVAYSVLVVAKVEKGKSKKLksvkeLLGITIMERSSFEK 1176
Cdd:pfam16595 1 KGGLFNQTILPahKKKGKGLIPLKKDergLDVEKYGGYSSLTAAYFSLVEYTGKKGKRKRT-----IEGVPLYLAAKIEE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1177 NPI--DFLEAKGYKEVKKDLIIKLPKYSLFElENGRKRMLASAGE---LQKGNELALPSKYVNFLYLASHYEKLKGSPED 1251
Cdd:pfam16595 76 NKDllEYLEEKLGLKEPKIILPKIKKNSLIK-IDGFRMLLTGKTEnrlLKNAVQLVLSNDDEKYIKKIEKFVKKNKDDII 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1252 NEQKQLFVEQHKHYLDEIIEQISEFSKrVILADANLDKVLSAYNKHRDKPIREQAENIIHLFTLTNLGA-PAAFKYFDTT 1330
Cdd:pfam16595 155 EEKDGLTEEKNIKLYDELLDKMKNTIY-YKRPSNQGEKLEKLKEKFIKLSLEEKCKVLIEILKLTHANPtSADLKLIGGS 233
|
250 260 270
....*....|....*....|....*....|.
gi 1916744588 1331 IDRKRYTSTKEVLDA---TLIHQSITGLYET 1358
Cdd:pfam16595 234 KHAGRIKISNNISKAsniKLINQSVTGLYEK 264
|
|
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
1469-1877 |
4.30e-07 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 55.33 E-value: 4.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1469 KRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPS--RSSASVPKPAPQPYPFTSSLSTinydefPTMVFPSGQISQASA 1546
Cdd:PHA03247 2663 RPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSlaDPPPPPPTPEPAPHALVSATPL------PPGPAAARQASPALP 2736
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1547 LAPAPPQVLPQAPAPAPAPAMVS--ALAQAPAPVPvlapgPPQAVAPPAPKPTQAGEGTLSEALlqlqfddedlgALLGN 1624
Cdd:PHA03247 2737 AAPAPPAVPAGPATPGGPARPARppTTAGPPAPAP-----PAAPAAGPPRRLTRPAVASLSESR-----------ESLPS 2800
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1625 STDPAVFTDLASVDNSEFQQLLNQGIPVAPHTtepmlmeypeaitrlvTGAQRPPDPAPAPLgAPGLPNGllsgdedfss 1704
Cdd:PHA03247 2801 PWDPADPPAAVLAPAAALPPAASPAGPLPPPT----------------SAQPTAPPPPPGPP-PPSLPLG---------- 2853
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1705 iadmdfSALLGSGSGSRDSREGMFLPKPEAGSAIsdvfEGREVCQPKRIRPFHP---PGSPWANRPLPASLAPTPTGPVH 1781
Cdd:PHA03247 2854 ------GSVAPGGDVRRRPPSRSPAAKPAAPARP----PVRRLARPAVSRSTESfalPPDQPERPPQPQAPPPPQPQPQP 2923
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1782 EPVGSLTPAPVPQPLDPAP-------AVTPEASHLLEDP--DEETSQAVKALREMADTVIPQKEEAAIcgqmdlSHPPPR 1852
Cdd:PHA03247 2924 PPPPQPQPPPPPPPRPQPPlapttdpAGAGEPSGAVPQPwlGALVPGRVAVPRFRVPQPAPSREAPAS------STPPLT 2997
|
410 420
....*....|....*....|....*
gi 1916744588 1853 GHLDeltTTLESMTEDLNLDSPLTP 1877
Cdd:PHA03247 2998 GHSL---SRVSSWASSLALHEETDP 3019
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| cas_Csn1 |
TIGR01865 |
CRISPR subtype II/NMENI RNA-guided endonuclease Cas9/Csn1; CRISPR loci appear to be mobile ... |
4-1050 |
0e+00 |
|
CRISPR subtype II/NMENI RNA-guided endonuclease Cas9/Csn1; CRISPR loci appear to be mobile elements with a wide host range. This model represents a protein found only in CRISPR-containing species, near other CRISPR-associated proteins (cas), as part of the NMENI subtype of CRISPR/Cas locus. The species range so far for this protein is animal pathogens and commensals only.
Pssm-ID: 273840 Cd Length: 805 Bit Score: 908.73 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 4 KYSIGLAIGTNSVGWAVITDEYKVPSKKFKVLGNtdrhsiKKNLIGALLFDSGETAE-ATRLKRTARRRYTRRKNRICYL 82
Cdd:TIGR01865 1 EYILGLDIGIASVGWAIVEDDYKVPAAKRLIDGG------VRNFTGAELPKTGETAAlDRRLARGARRRIRRRKHRLLRL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 83 QEIFSNEMAKVDDSFFHRLEESFLVEEDKKHerhpifgnivdevayhekypTIYHLRKKLVDSTDKADLrlIYLALAHMI 162
Cdd:TIGR01865 75 QELFSREGSLTDFDFFSRLENSFLVEEDKRN--------------------TIYHLRKAALENKLKPDE--LYLALLHII 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 163 KFRGHFLIEgdlnpdnsdvdklfiqlvqtynqlfeenpinasgvdakailsarlsksrrlenliaqlpgekknglfgnli 242
Cdd:TIGR01865 133 KHRGHFLIE----------------------------------------------------------------------- 141
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 243 alslgltpnfksnfdlaedaklqlskdtyDDDLDnllaqigdqyadlflaaknlsdaillsdilrVNTEITKAPLSASMI 322
Cdd:TIGR01865 142 -----------------------------GNDFD-------------------------------TANKETGALLSAVMI 161
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 323 KRYDEHHQDLTLLKALVRQQLPEKYKEIFFDqskngyagyidggasqeefykfikpilekmdgteellvklnreDLLRKQ 402
Cdd:TIGR01865 162 NRYLEHEADLRTLKELILKKFPKKYKEIFSE-------------------------------------------TFLRNQ 198
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 403 RTFDNGSIPHQIHLGELHAILRRQEDFYPFlkdnrekiEKILTFRIPYYVGPLARGNSRFAwmtrkseetitpwnfeeVV 482
Cdd:TIGR01865 199 RGFYNGSIPRQLLLEELEAIFRKQREYYPF--------IKLLTFRIPYYIGPLAEGKSEFA-----------------FV 253
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 483 DKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVTEGMRKPAFLSGEQKKAIVDLLFKTNRKVTVK 562
Cdd:TIGR01865 254 DKPASAENFIEKMTGKCTYLPEEKRAPKHSLLAEKFTVLNELNNVRIIILEQGETKILSKEEKQELLDLLFKKKKLTYKK 333
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 563 QLKEDYFKKIECFDSVEISGVEDR---FNASLGTYHDLLKIIKDKDFLDNEENEDILEDIVLTLTLFEDREMIEERLKTY 639
Cdd:TIGR01865 334 LRKLLGLSEDAIFKGLRYEGLDNAekaFNISLKTYHKLRKALGDKDLLDNPKNPKDLDEIVKILTLYKDREMIKKRLELY 413
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 640 AHLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQSGKTILDFLKSDGFANRNFMQLIHDDSLTFKEDIQKAqvsgqgds 719
Cdd:TIGR01865 414 KDVLNEEQVKKLVRLHFTGWGRLSLKALRGIRPLMEQGKRYDEAILELGGNRNFMQNINDSQLLPKINITKA-------- 485
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 720 lhehiANLAGSPAIKKGILQTVKVVDELVKVMGrhKPENIVIEMARENQTTQKGQKNSRERMKRIEEGIKELGS----QI 795
Cdd:TIGR01865 486 -----KDEILNPVVKRALLQARKVVNELVKKYG--PPDKIVIEMAREEQGTNFGKRNSKERYKKNEDKIKEFASalgkEI 558
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 796 LKEHPVENTQLQNEKLYLYYLQNGRDMYVDQELDINRL---SDYDVAAIVPQSFLKDDSIDNKVLTRSDKARGKSDNVPS 872
Cdd:TIGR01865 559 LKEEPTENSSKNILKLRLYYQQNGKCMYTGKEIDIDDLfdlSYYEIDHILPQSRSFDDSISNKVLVLASENQEKGDQTPY 638
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 873 E-EVVKKMKNYWRQLLNAKLITQRKFDNLTKAERGGLSELDKAGFIKRQLVETRQITKHVAQILDSRMNTKYDendklIR 951
Cdd:TIGR01865 639 EaEIVKKDSAFWNKFEAYVLISKRKSDKLTRAERGGLSDDDKAGFIDRNLNDTRYITRVVANYLKDRFNFHLK-----KR 713
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 952 EVKVITLKSKLVSDFRKDFQFYKVREINNYHHAHDAYLNAVVGTALIKKYPKLESEFVYGDYKVYDVRKMIAkseqeigK 1031
Cdd:TIGR01865 714 KVKVVTLKGQLTSQLRKKWGLYKKREINNYHHAHDAYINAVSTNALVKKFSQLEPEFRYKEYHNFDGRKKKK-------S 786
|
1050
....*....|....*....
gi 1916744588 1032 ATAKYFFYSNIMNFFKTEI 1050
Cdd:TIGR01865 787 ATDKKVKFSNPMEFFKQKV 805
|
|
| Csn1 |
cd09643 |
CRISPR/Cas system-associated protein Cas9; CRISPR (Clustered Regularly Interspaced Short ... |
4-1049 |
0e+00 |
|
CRISPR/Cas system-associated protein Cas9; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Very large protein containing McrA/HNH-nuclease related domain and a RuvC-like nuclease domain; signature gene for type II
Pssm-ID: 187774 [Multi-domain] Cd Length: 799 Bit Score: 894.08 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 4 KYSIGLAIGTNSVGWAVITDEYKVPSKKFKvlgntdrHSIKKNLIGALLFDSGETAE-ATRLKRTARRRYTRRKNRICYL 82
Cdd:cd09643 1 EYILGLDIGIASVGWAIVEDDYKVPAKKMI-------DCGVKIFTGAELFKTGETAAlDRRLARGARRRIRRRKHRLLRL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 83 QEIFSNEMAKVDDSFFHRLEESFLveedkkherhpifgnivdevAYHEKYPTIYHLRKKLVDSTDKADLrlIYLALAHMI 162
Cdd:cd09643 74 QELFAREGSLTDFDFFSRLEDSFL--------------------EYHKNYPTIYHLRKAALENKLKPDE--LYLALLHII 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 163 KFRGHFLIEGDLNPDNsdvdklfiqlvqtynqlfeenpinasgvdakailsarlsksrrlenliaqlpgekknglfgnli 242
Cdd:cd09643 132 KHRGHFLIEGDEDTTA---------------------------------------------------------------- 147
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 243 alslgltpnfksnfdlaedaklqlskdtydddldnllaqigdqyadlflaaknlsdaillsdilrvnTEITKAPLSASMI 322
Cdd:cd09643 148 -------------------------------------------------------------------DKETGALLSASMI 160
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 323 KRYDEHHQDLTLLKALVRQQLPEKYKEIFFDqskngyagyidggasqeefykfikpilekmdgteellvklnrEDLLRKQ 402
Cdd:cd09643 161 KRYDEHKADLRKLKELIKKEFFKKYKEIFGD------------------------------------------ETFLRNQ 198
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 403 RTFDNGSIPHQIHLGELHAILRRQEDFYPFlkdnrekiEKILTFRIPYYVGPLARGNSRFAWMTRKSEEtitpwnfeevv 482
Cdd:cd09643 199 RGFYNGSIPRQLLLEELEAIFRKQREYYPF--------EKILTFRIPYYIGPLAEGKSEFAWLTRPALS----------- 259
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 483 dkgasaQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVTEgMRKPAFLSGEQKKAIVDLLFKTNRKVTVK 562
Cdd:cd09643 260 ------EAFIEKMTGKCTYLPEEKRAPKHSLLAEKFTVLNELNNLRIIEE-QGETKILSKEEKQELLDLLFKKNKLTYKQ 332
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 563 QLKEDYFKKIECFDSVEISG--VEDRFNASLGTYHDLLKIIKDKDFLDNEENEDILEDIVLTLTLFEDREMIEERLKTYA 640
Cdd:cd09643 333 KRKLLGLKEEEIFKGLRYEGlkAEKNFNISLKTYHDLRKALGKEFLKDLELNEKILDEIVKILTLYKDREMIEKILELYK 412
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 641 HLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQSGKTILDFLKSDGFANRNfmQLIHDDSLTFKEDIQKAQVsgqgdsl 720
Cdd:cd09643 413 DLLNEEQLKKLLKRHFTGWGRLSLKALRGIRPLMEQGKRYDEAILELGGNHN--QKINSDELKFLPIIKKAQV------- 483
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 721 hehiANLAGSPAIKKGILQTVKVVDELVKVMGrhKPENIVIEMARENQtTQKGQKNSRERMKRIEEGIKELGS---QILK 797
Cdd:cd09643 484 ----KDEILNPVVKRALLQARKVVNELVKKYG--PPDKIVIEMARENG-TNKGTKNRKKRQKKNEDNIKEAASaleQKLK 556
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 798 EHPVENTQLQNEKLYLYYLQNGRDMYVDQELDINRL---SDYDVAAIVPQSFLKDDSIDNKVLTRSDKARGKSDNVPSEE 874
Cdd:cd09643 557 ELPLDIKSKNILKLRLYYQQNGKCMYTGKEIDIDDLfdlSYYEIDHILPQSRSFDDSISNKVLVLASENQEKGDQTPYEE 636
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 875 VVKKMKNYWRQLLNAKLITQR---KFDNLtKAERgGLSELDKAGFIKRQLVETRQITKHVAQILDSRMNTKYDendklIR 951
Cdd:cd09643 637 IVSKMSAFWNKLEAAKLISQRgdsKKDRL-LLEK-GISDDEKAGFIDRNLNDTRYITRVVANYLKDRFNFHLK-----KR 709
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 952 EVKVITLKSKLVSDFRKDFQFYKVREINNYHHAHDAYLNAVVGTALIKKYPKLEsefVYGDYKVYDVRKMIAKSEQEIgk 1031
Cdd:cd09643 710 KVKVVTLKGQLTSQLRKKWGLYKKREINNYHHAHDAYINAVVTNALVKKFSQLE---RYKEYKRFDSEKGNKKTLDEN-- 784
|
1050
....*....|....*...
gi 1916744588 1032 ataKYFFYSNIMNFFKTE 1049
Cdd:cd09643 785 ---KKFFFANPMNFFKQE 799
|
|
| Cas9_REC |
pfam16592 |
REC lobe of CRISPR-associated endonuclease Cas9; The REC lobe of Cas9 - the CRISPR-associated ... |
181-710 |
0e+00 |
|
REC lobe of CRISPR-associated endonuclease Cas9; The REC lobe of Cas9 - the CRISPR-associated endonuclease Cas9 - includes the REC1 and REC2 domains. REC1 forms an elongated, alpha-helical structure consisting of 25 alpha helices and two beta-sheets, whereas REC2 inserted within REC1 adopts a six-helix bundle structure. The REC lobe and the NUC lobe of Cas9 fold to present a positively charged groove at their interface which accommodates the negatively charged sgRNA:target DNA heteroduplex. CRISPR (clustered regularly interspaced short palindromic repeat)-Cas system occurs naturally in bacteria as a defence against invasion by phages or other mobile genetic elements. Cas9 is targeted to specific genomic locations by sgRNAs or single guide RNAs, in order to complex with invading DNA in order to cleave it and render it inactive.
Pssm-ID: 435447 Cd Length: 539 Bit Score: 588.26 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 181 VDKLFIQLVQTYNQLFEENPINASGVDAKAILSA-RLSKSRRLENLIAQLPGEK-KNGLFGNLIALSLGLTPNFKSNFDL 258
Cdd:pfam16592 1 VEESFQDLLNILYEQLENLELETQNVEIEKILKKtKISKKAKLDELLALPPNEKnSKKIFAEILKLILGNKADFTKIFEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 259 ------AEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDL 332
Cdd:pfam16592 81 ekfveePKKIKLSFSDSNYDEKIEELENQLGDEKAEIILILKKIYDWVVLSDILTVSTDNGKAYLSEAMVNRYDKHKEDL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 333 TLLKALVRQQLPEKYKEIFFDQSKNGYAGYID----GGASQEEFYKFIKPILEKMDGTE--ELLVKLNREDLLRKQRTFD 406
Cdd:pfam16592 161 AQLKKVIKQNLSEKYNDMFRKEKKKGYSAYINgknnGKTSKEDFYKYIKKLINKVETSEaqYILSKIDNENFLPKQRTKS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 407 NGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARGNSRFAWMTRKSEETITPWNFEEVVDKGA 486
Cdd:pfam16592 241 NGSIPYQVHLQELKKIIKNQAEYYPFLKENQEKILKLLTFRIPYYVGPLAEKKSKFAWMKRKEQGKIYPWNFEQKVDIDK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 487 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVTEgmrkpaFLSGEQKKAIVDLLFKTNRKVTVKQLKE 566
Cdd:pfam16592 321 TAEAFITRMTNYCTYLPDEKVLPKNSLLYSKFTVLNELNKIKINGE------KISVELKQDIFNGLFKKNKKVTKKKLKD 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 567 DYFKKIECFDSVEISGV--EDRFNASLGTYHDLLKIIkdKDFLDNEENEDILEDIVLTLTLFEDREMIEERL-KTYAHLF 643
Cdd:pfam16592 395 WLVKEGYNFKAVEIKGFdkENNFNNSLTTYIDLAKIF--GDFLDNPDNEDIIEDIIYWLTLFEDRKILKRRLqKKYSNLL 472
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 644 DDKVMKQLKRRRYTGWGRLSRKLINGIRDKQS---GKTILDFLKSDgfaNRNFMQLIHDDSLTFKEDIQK 710
Cdd:pfam16592 473 TEKQIKQILKLKYKGWGRLSKELLNGIRGADRqgeIKTIIDLLWND---NRNLMQLINDERLSFKEEIEK 539
|
|
| Cas9 |
COG3513 |
CRISPR-Cas system type-II protein Cas9 [Defense mechanisms]; CRISPR-Cas system type-II protein ... |
3-1130 |
9.62e-124 |
|
CRISPR-Cas system type-II protein Cas9 [Defense mechanisms]; CRISPR-Cas system type-II protein Cas9 is part of the Pathway/BioSystem: CRISPR-Cas system
Pssm-ID: 442735 [Multi-domain] Cd Length: 812 Bit Score: 410.89 E-value: 9.62e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 3 KKYSIGLAIGTNSVGWAVITDEYKVpskkfkvlgntdrHSIKKNLIGALLFDSGET-------AEATRLKRTARRRYTRR 75
Cdd:COG3513 2 DKYILGLDLGINSVGWAVLELDEDG-------------EPGEIIDAGVRIFDDGEDpksgeslAAARREARGARRRRRRR 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 76 KNRICYLQEIFSNEMakvddsffhrleesFLVEEDKKHERHPifgnivdevayhekYPTIYHLRKKLVDstDKADLRLIY 155
Cdd:COG3513 69 KHRLRRLKRLLVEEG--------------LLPADDAERKALL--------------PLNPYELRAKALD--EKLSPEELG 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 156 LALAHMIKFRGHfliegdLNPDNSDVDKLfiqlvqtynqlfeenpinasgvDAKAILSARLSKSRRLENLIAQLPGEkkn 235
Cdd:COG3513 119 RALFHLAQRRGF------KSNRKTDSKDN----------------------ESGKVKDAIKELRERLEAKGARTVGE--- 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 236 glfgnlialslgltpnfksnfdlaedaklqlskdtydddldnllaqigdqyadlFLAaknlsdaillsdilrvnteitka 315
Cdd:COG3513 168 ------------------------------------------------------YLY----------------------- 170
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 316 plsasmiKRYDEHHQdltllkalvrqqlpekykeiffdqskngyagyidggasqeefykfikpilekmdgteellvklnr 395
Cdd:COG3513 171 -------RRLQENGK----------------------------------------------------------------- 178
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 396 edlLRKQRTFDNGSIPHQIHLGELHAILRRQEDFYPFLKDN--REKIEKILTFRIPYYVGplargnsrfawmtrkseeti 473
Cdd:COG3513 179 ---VRNRKGDYDFYIPREDLEDEFEAIWAAQAEFGPALLTEelRDELLEIIFFQRPLKSG-------------------- 235
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 474 tpwnfeevvdkgasaqsfiERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVTEGmRKPAFLSGEQKKAIVDLLF 553
Cdd:COG3513 236 -------------------KKLVGKCTFEPDEKRAPKASPLFQRFRILQKLNNLRIVDDG-GEERPLTLEERQKIIDLLE 295
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 554 KtNRKVTVKQLKEDYfkKIEcfDSVEISGVEDRFN-----ASLGTYHDLLKIIKDKDFldNEENEDILEDIVLTLTLFED 628
Cdd:COG3513 296 N-KKKLTFKKLRKLL--GLP--DGVIFKGFNYEDDdraklKGDKTYAKLAKIFGKAWL--NEFDPEILDDIVEALTLFKD 368
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 629 REMIEERLKTYAHLfDDKVMKQLKRRR-YTGWGRLSRKLINGIrdkqsgktiLDFLKSDgfanrnfmqlihddsLTFKED 707
Cdd:COG3513 369 DEELKEWLKKLYGL-DEEQAEALANLPlPDGYGNLSLKALRKI---------LPLLEEG---------------LDYDEA 423
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 708 IQKAQVSGQGDSLH--------EHIANLAGSPAIKKGILQTVKVVDELVKVMGrhKPENIVIEMARENQTTQKGQKNSRE 779
Cdd:COG3513 424 VKAAGYDHSSLEILdrlppigeEKRKGSIRNPVVHRALNQLRKVVNALIRKYG--KPDEIHIELARDLKKSKKERKEIQK 501
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 780 RMKRIEEGIKELGSQILKEHPVENTQLQNEKLYLYYLQNGRDMYVDQELDINRLSD--YDVAAIVPQSFLKDDSIDNKVL 857
Cdd:COG3513 502 RQRENEKAREKAREEIAEEGGGEPSRRDILKYRLWEEQNGRCPYTGKPISISDLLDgsVEIDHILPRSRTLDDSFNNKVL 581
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 858 TRSDKARGKSDNVPSEEVVK----KMKNYWRQLLNAKLITQRKFDNLTKAERGglsELDKAGFIKRQLVETRQITKHVAQ 933
Cdd:COG3513 582 CLADANREKGNRTPYEALGGdeaeKWEEILARVENLKLIPQKKKKRFLKKELD---RDDDEGFIARQLNDTRYISRLAAE 658
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 934 ILDSRMNTKYdendklIREVKVITLKSKLVSDFRKDFQFYKV-------REINNYHHAHDAYLNAVVGTALIKKYPKLES 1006
Cdd:COG3513 659 YLKSLYPFED------KGKRKVRVVPGQLTAMLRRAWGLNKIlsddgekNRDDHRHHAIDALVIACTTQGLLQRLAKASR 732
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1007 EFVYgdykvydvrkmiakseqeigKATAKYFFYSNIMNFFKTeitlangeirkrplietngetgeivwdkgrDFATVRKV 1086
Cdd:COG3513 733 ERED--------------------AEKAEEHFPPPWDGFRQD------------------------------VAEAVDEI 762
|
1130 1140 1150 1160
....*....|....*....|....*....|....*....|....*
gi 1916744588 1087 LsmpqvnIVKKTEVQ-TGGFSKESILPKRNsDKLIARKKdWDPKK 1130
Cdd:COG3513 763 F------VSHAPRRKvTGQLHKETIYSTGE-GKVVLRKP-LTSLK 799
|
|
| Herpes_TAF50 |
pfam03326 |
Herpesvirus transcription activation factor (transactivator); This family includes EBV BRLF1 ... |
1719-1889 |
1.81e-70 |
|
Herpesvirus transcription activation factor (transactivator); This family includes EBV BRLF1 and similar ORF 50 proteins from other herpesviruses.
Pssm-ID: 308764 [Multi-domain] Cd Length: 568 Bit Score: 248.46 E-value: 1.81e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1719 GSRDSREGMFLPKPEAGSAISDVFEGREVCQPKRIRPFHPPGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDP 1798
Cdd:pfam03326 390 GLRDSRSTSFLTAPEATSAISDVFQGTEVCQPKRIRALHPPGSPSANRPLPSSLAPTPTGPVHEPGSSLTPATVPQPLDA 469
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1799 APAVTPEASHLLEDPDEETSQavkalremadtviPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPE 1878
Cdd:pfam03326 470 APVATPEASHELQPPDEETPQ-------------PLDEDQALCGQQDASHPPPRGQLDELTTTLESMTEDLNLDSPLSPE 536
|
170
....*....|.
gi 1916744588 1879 LNEILDTFLND 1889
Cdd:pfam03326 537 DNEILETILND 547
|
|
| Cas9_PI |
pfam16595 |
PAM-interacting domain of CRISPR-associated endonuclease Cas9; Cas9_PI is a family found at ... |
1102-1358 |
1.77e-48 |
|
PAM-interacting domain of CRISPR-associated endonuclease Cas9; Cas9_PI is a family found at the C-terminal of bacterial type II CRISPR system Cas9 endonuclease. This domain adopts a novel protein fold that is unique to the Cas9 family. It is positioned in the structure-DNA-complex to recognize the PAM sequence on the non-complementary DNA strand of the crRNA. PAM sequence is protospacer-adjacent motifs on DNA. See family CRISPR-DR2, Rfam:RF01315. Cas9 carries two nuclease domains, HNH and RuvC, which cleave the DNA strands that are complementary and non-complementary to the 20 nucleotide guide sequence in crRNAs, respectively.
Pssm-ID: 435449 Cd Length: 264 Bit Score: 174.43 E-value: 1.77e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1102 TGGFSKESILP--KRNSDKLIARKKD---WDPKKYGGFDSPTVAYSVLVVAKVEKGKSKKLksvkeLLGITIMERSSFEK 1176
Cdd:pfam16595 1 KGGLFNQTILPahKKKGKGLIPLKKDergLDVEKYGGYSSLTAAYFSLVEYTGKKGKRKRT-----IEGVPLYLAAKIEE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1177 NPI--DFLEAKGYKEVKKDLIIKLPKYSLFElENGRKRMLASAGE---LQKGNELALPSKYVNFLYLASHYEKLKGSPED 1251
Cdd:pfam16595 76 NKDllEYLEEKLGLKEPKIILPKIKKNSLIK-IDGFRMLLTGKTEnrlLKNAVQLVLSNDDEKYIKKIEKFVKKNKDDII 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1252 NEQKQLFVEQHKHYLDEIIEQISEFSKrVILADANLDKVLSAYNKHRDKPIREQAENIIHLFTLTNLGA-PAAFKYFDTT 1330
Cdd:pfam16595 155 EEKDGLTEEKNIKLYDELLDKMKNTIY-YKRPSNQGEKLEKLKEKFIKLSLEEKCKVLIEILKLTHANPtSADLKLIGGS 233
|
250 260 270
....*....|....*....|....*....|.
gi 1916744588 1331 IDRKRYTSTKEVLDA---TLIHQSITGLYET 1358
Cdd:pfam16595 234 KHAGRIKISNNISKAsniKLINQSVTGLYEK 264
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1469-1877 |
4.30e-07 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 55.33 E-value: 4.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1469 KRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPS--RSSASVPKPAPQPYPFTSSLSTinydefPTMVFPSGQISQASA 1546
Cdd:PHA03247 2663 RPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSlaDPPPPPPTPEPAPHALVSATPL------PPGPAAARQASPALP 2736
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1547 LAPAPPQVLPQAPAPAPAPAMVS--ALAQAPAPVPvlapgPPQAVAPPAPKPTQAGEGTLSEALlqlqfddedlgALLGN 1624
Cdd:PHA03247 2737 AAPAPPAVPAGPATPGGPARPARppTTAGPPAPAP-----PAAPAAGPPRRLTRPAVASLSESR-----------ESLPS 2800
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1625 STDPAVFTDLASVDNSEFQQLLNQGIPVAPHTtepmlmeypeaitrlvTGAQRPPDPAPAPLgAPGLPNGllsgdedfss 1704
Cdd:PHA03247 2801 PWDPADPPAAVLAPAAALPPAASPAGPLPPPT----------------SAQPTAPPPPPGPP-PPSLPLG---------- 2853
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1705 iadmdfSALLGSGSGSRDSREGMFLPKPEAGSAIsdvfEGREVCQPKRIRPFHP---PGSPWANRPLPASLAPTPTGPVH 1781
Cdd:PHA03247 2854 ------GSVAPGGDVRRRPPSRSPAAKPAAPARP----PVRRLARPAVSRSTESfalPPDQPERPPQPQAPPPPQPQPQP 2923
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1782 EPVGSLTPAPVPQPLDPAP-------AVTPEASHLLEDP--DEETSQAVKALREMADTVIPQKEEAAIcgqmdlSHPPPR 1852
Cdd:PHA03247 2924 PPPPQPQPPPPPPPRPQPPlapttdpAGAGEPSGAVPQPwlGALVPGRVAVPRFRVPQPAPSREAPAS------STPPLT 2997
|
410 420
....*....|....*....|....*
gi 1916744588 1853 GHLDeltTTLESMTEDLNLDSPLTP 1877
Cdd:PHA03247 2998 GHSL---SRVSSWASSLALHEETDP 3019
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1678-1826 |
3.75e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 52.25 E-value: 3.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1678 PPDPAPA-----------------PLGAP------GLPNGLLSGDEDFSSIADMDfsallgsgSGSRDSREGMfLPK--- 1731
Cdd:PHA03247 315 PPPPAPAgdaeeeddedgamevvsPLPRPrqhyplGFPKRRRPTWTPPSSLEDLS--------AGRHHPKRAS-LPTrkr 385
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1732 ---PEAGSAISDVFEGREVCQPKRIRPFHPPgSPWANrPLPASLAPTPTGP--VHEPVGSLTPAPVPQPLDPAPAVTPEA 1806
Cdd:PHA03247 386 rsaRHAATPFARGPGGDDQTRPAAPVPASVP-TPAPT-PVPASAPPPPATPlpSAEPGSDDGPAPPPERQPPAPATEPAP 463
|
170 180
....*....|....*....|
gi 1916744588 1807 ShlleDPDEETSQAVKALRE 1826
Cdd:PHA03247 464 D----DPDDATRKALDALRE 479
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| cas_Csn1 |
TIGR01865 |
CRISPR subtype II/NMENI RNA-guided endonuclease Cas9/Csn1; CRISPR loci appear to be mobile ... |
4-1050 |
0e+00 |
|
CRISPR subtype II/NMENI RNA-guided endonuclease Cas9/Csn1; CRISPR loci appear to be mobile elements with a wide host range. This model represents a protein found only in CRISPR-containing species, near other CRISPR-associated proteins (cas), as part of the NMENI subtype of CRISPR/Cas locus. The species range so far for this protein is animal pathogens and commensals only.
Pssm-ID: 273840 Cd Length: 805 Bit Score: 908.73 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 4 KYSIGLAIGTNSVGWAVITDEYKVPSKKFKVLGNtdrhsiKKNLIGALLFDSGETAE-ATRLKRTARRRYTRRKNRICYL 82
Cdd:TIGR01865 1 EYILGLDIGIASVGWAIVEDDYKVPAAKRLIDGG------VRNFTGAELPKTGETAAlDRRLARGARRRIRRRKHRLLRL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 83 QEIFSNEMAKVDDSFFHRLEESFLVEEDKKHerhpifgnivdevayhekypTIYHLRKKLVDSTDKADLrlIYLALAHMI 162
Cdd:TIGR01865 75 QELFSREGSLTDFDFFSRLENSFLVEEDKRN--------------------TIYHLRKAALENKLKPDE--LYLALLHII 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 163 KFRGHFLIEgdlnpdnsdvdklfiqlvqtynqlfeenpinasgvdakailsarlsksrrlenliaqlpgekknglfgnli 242
Cdd:TIGR01865 133 KHRGHFLIE----------------------------------------------------------------------- 141
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 243 alslgltpnfksnfdlaedaklqlskdtyDDDLDnllaqigdqyadlflaaknlsdaillsdilrVNTEITKAPLSASMI 322
Cdd:TIGR01865 142 -----------------------------GNDFD-------------------------------TANKETGALLSAVMI 161
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 323 KRYDEHHQDLTLLKALVRQQLPEKYKEIFFDqskngyagyidggasqeefykfikpilekmdgteellvklnreDLLRKQ 402
Cdd:TIGR01865 162 NRYLEHEADLRTLKELILKKFPKKYKEIFSE-------------------------------------------TFLRNQ 198
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 403 RTFDNGSIPHQIHLGELHAILRRQEDFYPFlkdnrekiEKILTFRIPYYVGPLARGNSRFAwmtrkseetitpwnfeeVV 482
Cdd:TIGR01865 199 RGFYNGSIPRQLLLEELEAIFRKQREYYPF--------IKLLTFRIPYYIGPLAEGKSEFA-----------------FV 253
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 483 DKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVTEGMRKPAFLSGEQKKAIVDLLFKTNRKVTVK 562
Cdd:TIGR01865 254 DKPASAENFIEKMTGKCTYLPEEKRAPKHSLLAEKFTVLNELNNVRIIILEQGETKILSKEEKQELLDLLFKKKKLTYKK 333
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 563 QLKEDYFKKIECFDSVEISGVEDR---FNASLGTYHDLLKIIKDKDFLDNEENEDILEDIVLTLTLFEDREMIEERLKTY 639
Cdd:TIGR01865 334 LRKLLGLSEDAIFKGLRYEGLDNAekaFNISLKTYHKLRKALGDKDLLDNPKNPKDLDEIVKILTLYKDREMIKKRLELY 413
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 640 AHLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQSGKTILDFLKSDGFANRNFMQLIHDDSLTFKEDIQKAqvsgqgds 719
Cdd:TIGR01865 414 KDVLNEEQVKKLVRLHFTGWGRLSLKALRGIRPLMEQGKRYDEAILELGGNRNFMQNINDSQLLPKINITKA-------- 485
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 720 lhehiANLAGSPAIKKGILQTVKVVDELVKVMGrhKPENIVIEMARENQTTQKGQKNSRERMKRIEEGIKELGS----QI 795
Cdd:TIGR01865 486 -----KDEILNPVVKRALLQARKVVNELVKKYG--PPDKIVIEMAREEQGTNFGKRNSKERYKKNEDKIKEFASalgkEI 558
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 796 LKEHPVENTQLQNEKLYLYYLQNGRDMYVDQELDINRL---SDYDVAAIVPQSFLKDDSIDNKVLTRSDKARGKSDNVPS 872
Cdd:TIGR01865 559 LKEEPTENSSKNILKLRLYYQQNGKCMYTGKEIDIDDLfdlSYYEIDHILPQSRSFDDSISNKVLVLASENQEKGDQTPY 638
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 873 E-EVVKKMKNYWRQLLNAKLITQRKFDNLTKAERGGLSELDKAGFIKRQLVETRQITKHVAQILDSRMNTKYDendklIR 951
Cdd:TIGR01865 639 EaEIVKKDSAFWNKFEAYVLISKRKSDKLTRAERGGLSDDDKAGFIDRNLNDTRYITRVVANYLKDRFNFHLK-----KR 713
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 952 EVKVITLKSKLVSDFRKDFQFYKVREINNYHHAHDAYLNAVVGTALIKKYPKLESEFVYGDYKVYDVRKMIAkseqeigK 1031
Cdd:TIGR01865 714 KVKVVTLKGQLTSQLRKKWGLYKKREINNYHHAHDAYINAVSTNALVKKFSQLEPEFRYKEYHNFDGRKKKK-------S 786
|
1050
....*....|....*....
gi 1916744588 1032 ATAKYFFYSNIMNFFKTEI 1050
Cdd:TIGR01865 787 ATDKKVKFSNPMEFFKQKV 805
|
|
| Csn1 |
cd09643 |
CRISPR/Cas system-associated protein Cas9; CRISPR (Clustered Regularly Interspaced Short ... |
4-1049 |
0e+00 |
|
CRISPR/Cas system-associated protein Cas9; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Very large protein containing McrA/HNH-nuclease related domain and a RuvC-like nuclease domain; signature gene for type II
Pssm-ID: 187774 [Multi-domain] Cd Length: 799 Bit Score: 894.08 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 4 KYSIGLAIGTNSVGWAVITDEYKVPSKKFKvlgntdrHSIKKNLIGALLFDSGETAE-ATRLKRTARRRYTRRKNRICYL 82
Cdd:cd09643 1 EYILGLDIGIASVGWAIVEDDYKVPAKKMI-------DCGVKIFTGAELFKTGETAAlDRRLARGARRRIRRRKHRLLRL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 83 QEIFSNEMAKVDDSFFHRLEESFLveedkkherhpifgnivdevAYHEKYPTIYHLRKKLVDSTDKADLrlIYLALAHMI 162
Cdd:cd09643 74 QELFAREGSLTDFDFFSRLEDSFL--------------------EYHKNYPTIYHLRKAALENKLKPDE--LYLALLHII 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 163 KFRGHFLIEGDLNPDNsdvdklfiqlvqtynqlfeenpinasgvdakailsarlsksrrlenliaqlpgekknglfgnli 242
Cdd:cd09643 132 KHRGHFLIEGDEDTTA---------------------------------------------------------------- 147
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 243 alslgltpnfksnfdlaedaklqlskdtydddldnllaqigdqyadlflaaknlsdaillsdilrvnTEITKAPLSASMI 322
Cdd:cd09643 148 -------------------------------------------------------------------DKETGALLSASMI 160
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 323 KRYDEHHQDLTLLKALVRQQLPEKYKEIFFDqskngyagyidggasqeefykfikpilekmdgteellvklnrEDLLRKQ 402
Cdd:cd09643 161 KRYDEHKADLRKLKELIKKEFFKKYKEIFGD------------------------------------------ETFLRNQ 198
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 403 RTFDNGSIPHQIHLGELHAILRRQEDFYPFlkdnrekiEKILTFRIPYYVGPLARGNSRFAWMTRKSEEtitpwnfeevv 482
Cdd:cd09643 199 RGFYNGSIPRQLLLEELEAIFRKQREYYPF--------EKILTFRIPYYIGPLAEGKSEFAWLTRPALS----------- 259
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 483 dkgasaQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVTEgMRKPAFLSGEQKKAIVDLLFKTNRKVTVK 562
Cdd:cd09643 260 ------EAFIEKMTGKCTYLPEEKRAPKHSLLAEKFTVLNELNNLRIIEE-QGETKILSKEEKQELLDLLFKKNKLTYKQ 332
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 563 QLKEDYFKKIECFDSVEISG--VEDRFNASLGTYHDLLKIIKDKDFLDNEENEDILEDIVLTLTLFEDREMIEERLKTYA 640
Cdd:cd09643 333 KRKLLGLKEEEIFKGLRYEGlkAEKNFNISLKTYHDLRKALGKEFLKDLELNEKILDEIVKILTLYKDREMIEKILELYK 412
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 641 HLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQSGKTILDFLKSDGFANRNfmQLIHDDSLTFKEDIQKAQVsgqgdsl 720
Cdd:cd09643 413 DLLNEEQLKKLLKRHFTGWGRLSLKALRGIRPLMEQGKRYDEAILELGGNHN--QKINSDELKFLPIIKKAQV------- 483
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 721 hehiANLAGSPAIKKGILQTVKVVDELVKVMGrhKPENIVIEMARENQtTQKGQKNSRERMKRIEEGIKELGS---QILK 797
Cdd:cd09643 484 ----KDEILNPVVKRALLQARKVVNELVKKYG--PPDKIVIEMARENG-TNKGTKNRKKRQKKNEDNIKEAASaleQKLK 556
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 798 EHPVENTQLQNEKLYLYYLQNGRDMYVDQELDINRL---SDYDVAAIVPQSFLKDDSIDNKVLTRSDKARGKSDNVPSEE 874
Cdd:cd09643 557 ELPLDIKSKNILKLRLYYQQNGKCMYTGKEIDIDDLfdlSYYEIDHILPQSRSFDDSISNKVLVLASENQEKGDQTPYEE 636
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 875 VVKKMKNYWRQLLNAKLITQR---KFDNLtKAERgGLSELDKAGFIKRQLVETRQITKHVAQILDSRMNTKYDendklIR 951
Cdd:cd09643 637 IVSKMSAFWNKLEAAKLISQRgdsKKDRL-LLEK-GISDDEKAGFIDRNLNDTRYITRVVANYLKDRFNFHLK-----KR 709
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 952 EVKVITLKSKLVSDFRKDFQFYKVREINNYHHAHDAYLNAVVGTALIKKYPKLEsefVYGDYKVYDVRKMIAKSEQEIgk 1031
Cdd:cd09643 710 KVKVVTLKGQLTSQLRKKWGLYKKREINNYHHAHDAYINAVVTNALVKKFSQLE---RYKEYKRFDSEKGNKKTLDEN-- 784
|
1050
....*....|....*...
gi 1916744588 1032 ataKYFFYSNIMNFFKTE 1049
Cdd:cd09643 785 ---KKFFFANPMNFFKQE 799
|
|
| Cas9_REC |
pfam16592 |
REC lobe of CRISPR-associated endonuclease Cas9; The REC lobe of Cas9 - the CRISPR-associated ... |
181-710 |
0e+00 |
|
REC lobe of CRISPR-associated endonuclease Cas9; The REC lobe of Cas9 - the CRISPR-associated endonuclease Cas9 - includes the REC1 and REC2 domains. REC1 forms an elongated, alpha-helical structure consisting of 25 alpha helices and two beta-sheets, whereas REC2 inserted within REC1 adopts a six-helix bundle structure. The REC lobe and the NUC lobe of Cas9 fold to present a positively charged groove at their interface which accommodates the negatively charged sgRNA:target DNA heteroduplex. CRISPR (clustered regularly interspaced short palindromic repeat)-Cas system occurs naturally in bacteria as a defence against invasion by phages or other mobile genetic elements. Cas9 is targeted to specific genomic locations by sgRNAs or single guide RNAs, in order to complex with invading DNA in order to cleave it and render it inactive.
Pssm-ID: 435447 Cd Length: 539 Bit Score: 588.26 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 181 VDKLFIQLVQTYNQLFEENPINASGVDAKAILSA-RLSKSRRLENLIAQLPGEK-KNGLFGNLIALSLGLTPNFKSNFDL 258
Cdd:pfam16592 1 VEESFQDLLNILYEQLENLELETQNVEIEKILKKtKISKKAKLDELLALPPNEKnSKKIFAEILKLILGNKADFTKIFEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 259 ------AEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSASMIKRYDEHHQDL 332
Cdd:pfam16592 81 ekfveePKKIKLSFSDSNYDEKIEELENQLGDEKAEIILILKKIYDWVVLSDILTVSTDNGKAYLSEAMVNRYDKHKEDL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 333 TLLKALVRQQLPEKYKEIFFDQSKNGYAGYID----GGASQEEFYKFIKPILEKMDGTE--ELLVKLNREDLLRKQRTFD 406
Cdd:pfam16592 161 AQLKKVIKQNLSEKYNDMFRKEKKKGYSAYINgknnGKTSKEDFYKYIKKLINKVETSEaqYILSKIDNENFLPKQRTKS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 407 NGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARGNSRFAWMTRKSEETITPWNFEEVVDKGA 486
Cdd:pfam16592 241 NGSIPYQVHLQELKKIIKNQAEYYPFLKENQEKILKLLTFRIPYYVGPLAEKKSKFAWMKRKEQGKIYPWNFEQKVDIDK 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 487 SAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVTEgmrkpaFLSGEQKKAIVDLLFKTNRKVTVKQLKE 566
Cdd:pfam16592 321 TAEAFITRMTNYCTYLPDEKVLPKNSLLYSKFTVLNELNKIKINGE------KISVELKQDIFNGLFKKNKKVTKKKLKD 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 567 DYFKKIECFDSVEISGV--EDRFNASLGTYHDLLKIIkdKDFLDNEENEDILEDIVLTLTLFEDREMIEERL-KTYAHLF 643
Cdd:pfam16592 395 WLVKEGYNFKAVEIKGFdkENNFNNSLTTYIDLAKIF--GDFLDNPDNEDIIEDIIYWLTLFEDRKILKRRLqKKYSNLL 472
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 644 DDKVMKQLKRRRYTGWGRLSRKLINGIRDKQS---GKTILDFLKSDgfaNRNFMQLIHDDSLTFKEDIQK 710
Cdd:pfam16592 473 TEKQIKQILKLKYKGWGRLSKELLNGIRGADRqgeIKTIIDLLWND---NRNLMQLINDERLSFKEEIEK 539
|
|
| Cas9 |
COG3513 |
CRISPR-Cas system type-II protein Cas9 [Defense mechanisms]; CRISPR-Cas system type-II protein ... |
3-1130 |
9.62e-124 |
|
CRISPR-Cas system type-II protein Cas9 [Defense mechanisms]; CRISPR-Cas system type-II protein Cas9 is part of the Pathway/BioSystem: CRISPR-Cas system
Pssm-ID: 442735 [Multi-domain] Cd Length: 812 Bit Score: 410.89 E-value: 9.62e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 3 KKYSIGLAIGTNSVGWAVITDEYKVpskkfkvlgntdrHSIKKNLIGALLFDSGET-------AEATRLKRTARRRYTRR 75
Cdd:COG3513 2 DKYILGLDLGINSVGWAVLELDEDG-------------EPGEIIDAGVRIFDDGEDpksgeslAAARREARGARRRRRRR 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 76 KNRICYLQEIFSNEMakvddsffhrleesFLVEEDKKHERHPifgnivdevayhekYPTIYHLRKKLVDstDKADLRLIY 155
Cdd:COG3513 69 KHRLRRLKRLLVEEG--------------LLPADDAERKALL--------------PLNPYELRAKALD--EKLSPEELG 118
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 156 LALAHMIKFRGHfliegdLNPDNSDVDKLfiqlvqtynqlfeenpinasgvDAKAILSARLSKSRRLENLIAQLPGEkkn 235
Cdd:COG3513 119 RALFHLAQRRGF------KSNRKTDSKDN----------------------ESGKVKDAIKELRERLEAKGARTVGE--- 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 236 glfgnlialslgltpnfksnfdlaedaklqlskdtydddldnllaqigdqyadlFLAaknlsdaillsdilrvnteitka 315
Cdd:COG3513 168 ------------------------------------------------------YLY----------------------- 170
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 316 plsasmiKRYDEHHQdltllkalvrqqlpekykeiffdqskngyagyidggasqeefykfikpilekmdgteellvklnr 395
Cdd:COG3513 171 -------RRLQENGK----------------------------------------------------------------- 178
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 396 edlLRKQRTFDNGSIPHQIHLGELHAILRRQEDFYPFLKDN--REKIEKILTFRIPYYVGplargnsrfawmtrkseeti 473
Cdd:COG3513 179 ---VRNRKGDYDFYIPREDLEDEFEAIWAAQAEFGPALLTEelRDELLEIIFFQRPLKSG-------------------- 235
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 474 tpwnfeevvdkgasaqsfiERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVTEGmRKPAFLSGEQKKAIVDLLF 553
Cdd:COG3513 236 -------------------KKLVGKCTFEPDEKRAPKASPLFQRFRILQKLNNLRIVDDG-GEERPLTLEERQKIIDLLE 295
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 554 KtNRKVTVKQLKEDYfkKIEcfDSVEISGVEDRFN-----ASLGTYHDLLKIIKDKDFldNEENEDILEDIVLTLTLFED 628
Cdd:COG3513 296 N-KKKLTFKKLRKLL--GLP--DGVIFKGFNYEDDdraklKGDKTYAKLAKIFGKAWL--NEFDPEILDDIVEALTLFKD 368
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 629 REMIEERLKTYAHLfDDKVMKQLKRRR-YTGWGRLSRKLINGIrdkqsgktiLDFLKSDgfanrnfmqlihddsLTFKED 707
Cdd:COG3513 369 DEELKEWLKKLYGL-DEEQAEALANLPlPDGYGNLSLKALRKI---------LPLLEEG---------------LDYDEA 423
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 708 IQKAQVSGQGDSLH--------EHIANLAGSPAIKKGILQTVKVVDELVKVMGrhKPENIVIEMARENQTTQKGQKNSRE 779
Cdd:COG3513 424 VKAAGYDHSSLEILdrlppigeEKRKGSIRNPVVHRALNQLRKVVNALIRKYG--KPDEIHIELARDLKKSKKERKEIQK 501
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 780 RMKRIEEGIKELGSQILKEHPVENTQLQNEKLYLYYLQNGRDMYVDQELDINRLSD--YDVAAIVPQSFLKDDSIDNKVL 857
Cdd:COG3513 502 RQRENEKAREKAREEIAEEGGGEPSRRDILKYRLWEEQNGRCPYTGKPISISDLLDgsVEIDHILPRSRTLDDSFNNKVL 581
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 858 TRSDKARGKSDNVPSEEVVK----KMKNYWRQLLNAKLITQRKFDNLTKAERGglsELDKAGFIKRQLVETRQITKHVAQ 933
Cdd:COG3513 582 CLADANREKGNRTPYEALGGdeaeKWEEILARVENLKLIPQKKKKRFLKKELD---RDDDEGFIARQLNDTRYISRLAAE 658
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 934 ILDSRMNTKYdendklIREVKVITLKSKLVSDFRKDFQFYKV-------REINNYHHAHDAYLNAVVGTALIKKYPKLES 1006
Cdd:COG3513 659 YLKSLYPFED------KGKRKVRVVPGQLTAMLRRAWGLNKIlsddgekNRDDHRHHAIDALVIACTTQGLLQRLAKASR 732
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1007 EFVYgdykvydvrkmiakseqeigKATAKYFFYSNIMNFFKTeitlangeirkrplietngetgeivwdkgrDFATVRKV 1086
Cdd:COG3513 733 ERED--------------------AEKAEEHFPPPWDGFRQD------------------------------VAEAVDEI 762
|
1130 1140 1150 1160
....*....|....*....|....*....|....*....|....*
gi 1916744588 1087 LsmpqvnIVKKTEVQ-TGGFSKESILPKRNsDKLIARKKdWDPKK 1130
Cdd:COG3513 763 F------VSHAPRRKvTGQLHKETIYSTGE-GKVVLRKP-LTSLK 799
|
|
| Herpes_TAF50 |
pfam03326 |
Herpesvirus transcription activation factor (transactivator); This family includes EBV BRLF1 ... |
1719-1889 |
1.81e-70 |
|
Herpesvirus transcription activation factor (transactivator); This family includes EBV BRLF1 and similar ORF 50 proteins from other herpesviruses.
Pssm-ID: 308764 [Multi-domain] Cd Length: 568 Bit Score: 248.46 E-value: 1.81e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1719 GSRDSREGMFLPKPEAGSAISDVFEGREVCQPKRIRPFHPPGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDP 1798
Cdd:pfam03326 390 GLRDSRSTSFLTAPEATSAISDVFQGTEVCQPKRIRALHPPGSPSANRPLPSSLAPTPTGPVHEPGSSLTPATVPQPLDA 469
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1799 APAVTPEASHLLEDPDEETSQavkalremadtviPQKEEAAICGQMDLSHPPPRGHLDELTTTLESMTEDLNLDSPLTPE 1878
Cdd:pfam03326 470 APVATPEASHELQPPDEETPQ-------------PLDEDQALCGQQDASHPPPRGQLDELTTTLESMTEDLNLDSPLSPE 536
|
170
....*....|.
gi 1916744588 1879 LNEILDTFLND 1889
Cdd:pfam03326 537 DNEILETILND 547
|
|
| Cas9_PI |
pfam16595 |
PAM-interacting domain of CRISPR-associated endonuclease Cas9; Cas9_PI is a family found at ... |
1102-1358 |
1.77e-48 |
|
PAM-interacting domain of CRISPR-associated endonuclease Cas9; Cas9_PI is a family found at the C-terminal of bacterial type II CRISPR system Cas9 endonuclease. This domain adopts a novel protein fold that is unique to the Cas9 family. It is positioned in the structure-DNA-complex to recognize the PAM sequence on the non-complementary DNA strand of the crRNA. PAM sequence is protospacer-adjacent motifs on DNA. See family CRISPR-DR2, Rfam:RF01315. Cas9 carries two nuclease domains, HNH and RuvC, which cleave the DNA strands that are complementary and non-complementary to the 20 nucleotide guide sequence in crRNAs, respectively.
Pssm-ID: 435449 Cd Length: 264 Bit Score: 174.43 E-value: 1.77e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1102 TGGFSKESILP--KRNSDKLIARKKD---WDPKKYGGFDSPTVAYSVLVVAKVEKGKSKKLksvkeLLGITIMERSSFEK 1176
Cdd:pfam16595 1 KGGLFNQTILPahKKKGKGLIPLKKDergLDVEKYGGYSSLTAAYFSLVEYTGKKGKRKRT-----IEGVPLYLAAKIEE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1177 NPI--DFLEAKGYKEVKKDLIIKLPKYSLFElENGRKRMLASAGE---LQKGNELALPSKYVNFLYLASHYEKLKGSPED 1251
Cdd:pfam16595 76 NKDllEYLEEKLGLKEPKIILPKIKKNSLIK-IDGFRMLLTGKTEnrlLKNAVQLVLSNDDEKYIKKIEKFVKKNKDDII 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1252 NEQKQLFVEQHKHYLDEIIEQISEFSKrVILADANLDKVLSAYNKHRDKPIREQAENIIHLFTLTNLGA-PAAFKYFDTT 1330
Cdd:pfam16595 155 EEKDGLTEEKNIKLYDELLDKMKNTIY-YKRPSNQGEKLEKLKEKFIKLSLEEKCKVLIEILKLTHANPtSADLKLIGGS 233
|
250 260 270
....*....|....*....|....*....|.
gi 1916744588 1331 IDRKRYTSTKEVLDA---TLIHQSITGLYET 1358
Cdd:pfam16595 234 KHAGRIKISNNISKAsniKLINQSVTGLYEK 264
|
|
| HNH_4 |
pfam13395 |
HNH endonuclease; This HNH nuclease domain is found in CRISPR-related proteins. |
821-871 |
6.29e-09 |
|
HNH endonuclease; This HNH nuclease domain is found in CRISPR-related proteins.
Pssm-ID: 433172 [Multi-domain] Cd Length: 55 Bit Score: 53.40 E-value: 6.29e-09
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1916744588 821 DMYVDQELDINRLSD---YDVAAIVPQSFLKDDSIDNKVLTRSDKARGKSDNVP 871
Cdd:pfam13395 1 CPYTGEQISIDDLFSeknYDIDHILPYSRSFDDSFSNKVLVLRSANQEKGNRTP 54
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1469-1877 |
4.30e-07 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 55.33 E-value: 4.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1469 KRKRTYETFKSIMKKSPFSGPTDPRPPPRRIAVPS--RSSASVPKPAPQPYPFTSSLSTinydefPTMVFPSGQISQASA 1546
Cdd:PHA03247 2663 RPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSlaDPPPPPPTPEPAPHALVSATPL------PPGPAAARQASPALP 2736
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1547 LAPAPPQVLPQAPAPAPAPAMVS--ALAQAPAPVPvlapgPPQAVAPPAPKPTQAGEGTLSEALlqlqfddedlgALLGN 1624
Cdd:PHA03247 2737 AAPAPPAVPAGPATPGGPARPARppTTAGPPAPAP-----PAAPAAGPPRRLTRPAVASLSESR-----------ESLPS 2800
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1625 STDPAVFTDLASVDNSEFQQLLNQGIPVAPHTtepmlmeypeaitrlvTGAQRPPDPAPAPLgAPGLPNGllsgdedfss 1704
Cdd:PHA03247 2801 PWDPADPPAAVLAPAAALPPAASPAGPLPPPT----------------SAQPTAPPPPPGPP-PPSLPLG---------- 2853
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1705 iadmdfSALLGSGSGSRDSREGMFLPKPEAGSAIsdvfEGREVCQPKRIRPFHP---PGSPWANRPLPASLAPTPTGPVH 1781
Cdd:PHA03247 2854 ------GSVAPGGDVRRRPPSRSPAAKPAAPARP----PVRRLARPAVSRSTESfalPPDQPERPPQPQAPPPPQPQPQP 2923
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1782 EPVGSLTPAPVPQPLDPAP-------AVTPEASHLLEDP--DEETSQAVKALREMADTVIPQKEEAAIcgqmdlSHPPPR 1852
Cdd:PHA03247 2924 PPPPQPQPPPPPPPRPQPPlapttdpAGAGEPSGAVPQPwlGALVPGRVAVPRFRVPQPAPSREAPAS------STPPLT 2997
|
410 420
....*....|....*....|....*
gi 1916744588 1853 GHLDeltTTLESMTEDLNLDSPLTP 1877
Cdd:PHA03247 2998 GHSL---SRVSSWASSLALHEETDP 3019
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1678-1826 |
3.75e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 52.25 E-value: 3.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1678 PPDPAPA-----------------PLGAP------GLPNGLLSGDEDFSSIADMDfsallgsgSGSRDSREGMfLPK--- 1731
Cdd:PHA03247 315 PPPPAPAgdaeeeddedgamevvsPLPRPrqhyplGFPKRRRPTWTPPSSLEDLS--------AGRHHPKRAS-LPTrkr 385
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1732 ---PEAGSAISDVFEGREVCQPKRIRPFHPPgSPWANrPLPASLAPTPTGP--VHEPVGSLTPAPVPQPLDPAPAVTPEA 1806
Cdd:PHA03247 386 rsaRHAATPFARGPGGDDQTRPAAPVPASVP-TPAPT-PVPASAPPPPATPlpSAEPGSDDGPAPPPERQPPAPATEPAP 463
|
170 180
....*....|....*....|
gi 1916744588 1807 ShlleDPDEETSQAVKALRE 1826
Cdd:PHA03247 464 D----DPDDATRKALDALRE 479
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
1650-1813 |
3.63e-05 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 48.91 E-value: 3.63e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1650 IPVAPHTTEPMLMEYPEAitrlVTGAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSAllgSGSGSRDSREGMFL 1729
Cdd:PHA03378 672 IPYQPSPTGANTMLPIQW----APGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAA---PGRARPPAAAPGRA 744
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1730 PKPEAGSAISDvfegREVCQPKRIRPfhPPGSPWANRPLPASLAPtPTgPVHEPVGSLTPAPVPQPLDPAPAVTPEASHL 1809
Cdd:PHA03378 745 RPPAAAPGRAR----PPAAAPGRARP--PAAAPGAPTPQPPPQAP-PA-PQQRPRGAPTPQPPPQAGPTSMQLMPRAAPG 816
|
....
gi 1916744588 1810 LEDP 1813
Cdd:PHA03378 817 QQGP 820
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
1674-1846 |
6.01e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 41.51 E-value: 6.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1674 GAQRPPDPAPAPLGAPGLPNGLLSGDEDFSSIADMDFSALLGSGSGSRDSREGMflPKPEAGSAISDVFEGREVCQPKRI 1753
Cdd:PRK07764 631 GAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPA--PAPAAPAAPAGAAPAQPAPAPAAT 708
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1916744588 1754 RPFHPPGSPWANRPLPASLA-----------PTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEASHLLEDPDEETSQAVK 1822
Cdd:PRK07764 709 PPAGQADDPAAQPPQAAQGAsapspaaddpvPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAED 788
|
170 180
....*....|....*....|....
gi 1916744588 1823 ALREMADTVIPQKEEAAicgqMDL 1846
Cdd:PRK07764 789 DAPSMDDEDRRDAEEVA----MEL 808
|
|
| PRK14965 |
PRK14965 |
DNA polymerase III subunits gamma and tau; Provisional |
1750-1807 |
6.10e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237871 [Multi-domain] Cd Length: 576 Bit Score: 41.27 E-value: 6.10e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 1916744588 1750 PKRIRPFHPPGSPWANRPLPASLAPTPTGPVHEPVGSLTPAPVPQPLDPAPAVTPEAS 1807
Cdd:PRK14965 382 PAPPSAAWGAPTPAAPAAPPPAAAPPVPPAAPARPAAARPAPAPAPPAAAAPPARSAD 439
|
|
| |
