NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|19111873|ref|NP_595081|]
View 

Fzy-like protein Mfr1 [Schizosaccharomyces pombe]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
138-408 6.95e-45

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 160.46  E-value: 6.95e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873 138 VLAVGLASSIYLWSAASGKVVQLHdFGATNHVTSVLWTGKGTQLAVGTDSGVIYIWDIESTKSVRSLKGHSERVAALAW- 216
Cdd:COG2319  93 LASASADGTVRLWDLATGLLLRTL-TGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFs 171

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873 217 -NDNTLTSGGKDEVILHHDLRAPGCCAEmMKVHEQEICGLQWDRSLGQLASGGNDNNLFVWDYRSSRPLHKFEEHTAAVK 295
Cdd:COG2319 172 pDGKLLASGSDDGTVRLWDLATGKLLRT-LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVR 250

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873 296 AIGWSPHQRgILASGGGtiDRCLTIHNTLTGRLQNKLDT-GSQVCNMAWSKTSNEIVTthGFAKNQVSLWKYPSLKNIAN 374
Cdd:COG2319 251 SVAFSPDGR-LLASGSA--DGTVRLWDLATGELLRTLTGhSGGVNSVAFSPDGKLLAS--GSDDGTVRLWDLATGKLLRT 325

                       250       260       270
                ....*....|....*....|....*....|....
gi 19111873 375 LTAHTNRVLYLSMSPDGQSIVTGAGDETLRFWKL 408
Cdd:COG2319 326 LTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
138-408 6.95e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 160.46  E-value: 6.95e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873 138 VLAVGLASSIYLWSAASGKVVQLHdFGATNHVTSVLWTGKGTQLAVGTDSGVIYIWDIESTKSVRSLKGHSERVAALAW- 216
Cdd:COG2319  93 LASASADGTVRLWDLATGLLLRTL-TGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFs 171

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873 217 -NDNTLTSGGKDEVILHHDLRAPGCCAEmMKVHEQEICGLQWDRSLGQLASGGNDNNLFVWDYRSSRPLHKFEEHTAAVK 295
Cdd:COG2319 172 pDGKLLASGSDDGTVRLWDLATGKLLRT-LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVR 250

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873 296 AIGWSPHQRgILASGGGtiDRCLTIHNTLTGRLQNKLDT-GSQVCNMAWSKTSNEIVTthGFAKNQVSLWKYPSLKNIAN 374
Cdd:COG2319 251 SVAFSPDGR-LLASGSA--DGTVRLWDLATGELLRTLTGhSGGVNSVAFSPDGKLLAS--GSDDGTVRLWDLATGKLLRT 325

                       250       260       270
                ....*....|....*....|....*....|....
gi 19111873 375 LTAHTNRVLYLSMSPDGQSIVTGAGDETLRFWKL 408
Cdd:COG2319 326 LTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 135-407 1.09e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 140.93  E-value: 1.09e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873 135 QSNVLAVGLA-SSIYLWSAASGKVV---QLHDFGatnhVTSVLWTGKGTQLAVGTDSGVIYIWDIESTKSVRSLKGHSER 210
Cdd:cd00200  20 DGKLLATGSGdGTIKVWDLETGELLrtlKGHTGP----VRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSY 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873 211 VAALAWNDNT--LTSGGKDEVILHHDLRAPGCCAEmMKVHEQEICGLQWDRSLGQLASGGNDNNLFVWDYRSSRPLHKFE 288
Cdd:cd00200  96 VSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTT-LRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLT 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873 289 EHTAAVKAIGWSPHQRGILASGGgtiDRCLTIHNTLTGRLQNKLDT-GSQVCNMAWSKTSNEIVTthGFAKNQVSLWKYP 367
Cdd:cd00200 175 GHTGEVNSVAFSPDGEKLLSSSS---DGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLAS--GSEDGTIRVWDLR 249

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 19111873 368 SLKNIANLTAHTNRVLYLSMSPDGQSIVTGAGDETLRFWK 407
Cdd:cd00200 250 TGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 156-219 2.64e-06

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 45.35  E-value: 2.64e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19111873   156 KVVQLHDFGATNHVTSVLWTGKGTQLAVGTDSGVIYIWDIESTKSVRSLKGHSERVAALAWNDN 219
Cdd:pfam12894  28 RVWTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWGEN 91
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 157-297 7.12e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.16  E-value: 7.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873  157 VVQLhdfGATNHVTSVLWTGK-GTQLAVGTDSGVIYIWDIESTKSVRSLKGHSERVAALAWN--DNTLTSGGKDEVILHH 233
Cdd:PLN00181 526 VVEL---ASRSKLSGICWNSYiKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSsaDPTLLASGSDDGSVKL 602

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19111873  234 DLRAPGCCAEMMKVhEQEICGLQWDRSLGQ-LASGGNDNNLFVWDYRSSR-PLHKFEEHTAAVKAI 297
Cdd:PLN00181 603 WSINQGVSIGTIKT-KANICCVQFPSESGRsLAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVSYV 667
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 368-407 3.27e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 3.27e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 19111873    368 SLKNIANLTAHTNRVLYLSMSPDGQSIVTGAGDETLRFWK 407
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
138-408 6.95e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 160.46  E-value: 6.95e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873 138 VLAVGLASSIYLWSAASGKVVQLHdFGATNHVTSVLWTGKGTQLAVGTDSGVIYIWDIESTKSVRSLKGHSERVAALAW- 216
Cdd:COG2319  93 LASASADGTVRLWDLATGLLLRTL-TGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFs 171

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873 217 -NDNTLTSGGKDEVILHHDLRAPGCCAEmMKVHEQEICGLQWDRSLGQLASGGNDNNLFVWDYRSSRPLHKFEEHTAAVK 295
Cdd:COG2319 172 pDGKLLASGSDDGTVRLWDLATGKLLRT-LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVR 250

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873 296 AIGWSPHQRgILASGGGtiDRCLTIHNTLTGRLQNKLDT-GSQVCNMAWSKTSNEIVTthGFAKNQVSLWKYPSLKNIAN 374
Cdd:COG2319 251 SVAFSPDGR-LLASGSA--DGTVRLWDLATGELLRTLTGhSGGVNSVAFSPDGKLLAS--GSDDGTVRLWDLATGKLLRT 325

                       250       260       270
                ....*....|....*....|....*....|....
gi 19111873 375 LTAHTNRVLYLSMSPDGQSIVTGAGDETLRFWKL 408
Cdd:COG2319 326 LTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL 359
WD40 COG2319
WD40 repeat [General function prediction only];
138-408 6.99e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 152.37  E-value: 6.99e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873 138 VLAVGLASSIYLWSAASGKVVQ-LHdfGATNHVTSVLWTGKGTQLAVGTDSGVIYIWDIESTKSVRSLKGHSERVAALAW 216
Cdd:COG2319 135 LASGSADGTVRLWDLATGKLLRtLT--GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF 212

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873 217 --NDNTLTSGGKDEVILHHDLRAPGCCAEmMKVHEQEICGLQWDRSlGQ-LASGGNDNNLFVWDYRSSRPLHKFEEHTAA 293
Cdd:COG2319 213 spDGKLLASGSADGTVRLWDLATGKLLRT-LTGHSGSVRSVAFSPD-GRlLASGSADGTVRLWDLATGELLRTLTGHSGG 290

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873 294 VKAIGWSPHQRgILASGG--GTIdrclTIHNTLTGRLQNKLD-TGSQVCNMAWSKTSNEIVTthGFAKNQVSLWKYPSLK 370
Cdd:COG2319 291 VNSVAFSPDGK-LLASGSddGTV----RLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLAS--GSDDGTVRLWDLATGE 363

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 19111873 371 NIANLTAHTNRVLYLSMSPDGQSIVTGAGDETLRFWKL 408
Cdd:COG2319 364 LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 135-407 1.09e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 140.93  E-value: 1.09e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873 135 QSNVLAVGLA-SSIYLWSAASGKVV---QLHDFGatnhVTSVLWTGKGTQLAVGTDSGVIYIWDIESTKSVRSLKGHSER 210
Cdd:cd00200  20 DGKLLATGSGdGTIKVWDLETGELLrtlKGHTGP----VRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSY 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873 211 VAALAWNDNT--LTSGGKDEVILHHDLRAPGCCAEmMKVHEQEICGLQWDRSLGQLASGGNDNNLFVWDYRSSRPLHKFE 288
Cdd:cd00200  96 VSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTT-LRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLT 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873 289 EHTAAVKAIGWSPHQRGILASGGgtiDRCLTIHNTLTGRLQNKLDT-GSQVCNMAWSKTSNEIVTthGFAKNQVSLWKYP 367
Cdd:cd00200 175 GHTGEVNSVAFSPDGEKLLSSSS---DGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLAS--GSEDGTIRVWDLR 249

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 19111873 368 SLKNIANLTAHTNRVLYLSMSPDGQSIVTGAGDETLRFWK 407
Cdd:cd00200 250 TGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
138-408 1.23e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.12  E-value: 1.23e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873 138 VLAVGLASSIYLWSAASGKVVQLHDFGATNHVTSVLWTGKGTQLAVGTDSGVIYIWDIESTKSVRSLKGHSERVAALAW- 216
Cdd:COG2319  50 RLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFs 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873 217 -NDNTLTSGGKDEVILHHDLRAPGCCAEmMKVHEQEICGLQWDRSlGQ-LASGGNDNNLFVWDYRSSRPLHKFEEHTAAV 294
Cdd:COG2319 130 pDGKTLASGSADGTVRLWDLATGKLLRT-LTGHSGAVTSVAFSPD-GKlLASGSDDGTVRLWDLATGKLLRTLTGHTGAV 207

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873 295 KAIGWSPHQRgILASGGGtiDRCLTIHNTLTGRLQNKLDT-GSQVCNMAWSKTSNEIVTthGFAKNQVSLWKYPSLKNIA 373
Cdd:COG2319 208 RSVAFSPDGK-LLASGSA--DGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLAS--GSADGTVRLWDLATGELLR 282

                       250       260       270
                ....*....|....*....|....*....|....*
gi 19111873 374 NLTAHTNRVLYLSMSPDGQSIVTGAGDETLRFWKL 408
Cdd:COG2319 283 TLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL 317
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 169-414 5.76e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 125.53  E-value: 5.76e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873 169 VTSVLWTGKGTQLAVGTDSGVIYIWDIESTKSVRSLKGHSERVAALAW--NDNTLTSGGKDEVILHHDLRAPGCCAEMmK 246
Cdd:cd00200  12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVRTL-T 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873 247 VHEQEICGLQWDRSLGQLASGGNDNNLFVWDYRSSRPLHKFEEHTAAVKAIGWSPHQRgILASGGGtiDRCLTIHNTLTG 326
Cdd:cd00200  91 GHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGT-FVASSSQ--DGTIKLWDLRTG 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873 327 RLQNKLdTG--SQVCNMAWSKTSNEIVTthGFAKNQVSLWKYPSLKNIANLTAHTNRVLYLSMSPDGQSIVTGAGDETLR 404
Cdd:cd00200 168 KCVATL-TGhtGEVNSVAFSPDGEKLLS--SSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIR 244

                       250
                ....*....|
gi 19111873 405 FWKLFNKKPK 414
Cdd:cd00200 245 VWDLRTGECV 254
WD40 COG2319
WD40 repeat [General function prediction only];
131-408 1.30e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.08  E-value: 1.30e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873 131 LDWGQSNVLAVGLASSIYLWSAASGKVVQLHDFGATNHVTSVLWTGKGTQLAVGTDSGVIYIWDIESTKSVRSLKGHSER 210
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873 211 VAALAW--NDNTLTSGGKDEVILHHDLRAPGCCAEMMKvHEQEICGLQWDRSLGQLASGGNDNNLFVWDYRSSRPLHKFE 288
Cdd:COG2319  81 VLSVAFspDGRLLASASADGTVRLWDLATGLLLRTLTG-HTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873 289 EHTAAVKAIGWSPHQRgILASGGGtiDRCLTIHNTLTGRLQNKLD-TGSQVCNMAWSKTSNEIVTthGFAKNQVSLWKYP 367
Cdd:COG2319 160 GHSGAVTSVAFSPDGK-LLASGSD--DGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLAS--GSADGTVRLWDLA 234

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 19111873 368 SLKNIANLTAHTNRVLYLSMSPDGQSIVTGAGDETLRFWKL 408
Cdd:COG2319 235 TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL 275
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 200-408 5.57e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 108.96  E-value: 5.57e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873 200 SVRSLKGHSERVAALAWND--NTLTSGGKDEVILHHDLrAPGCCAEMMKVHEQEICGLQWDRSLGQLASGGNDNNLFVWD 277
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPdgKLLATGSGDGTIKVWDL-ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873 278 YRSSRPLHKFEEHTAAVKAIGWSPHQRgILASGGGtiDRCLTIHNTLTGRLQNKLDT-GSQVCNMAWSKTsNEIVTThGF 356
Cdd:cd00200  80 LETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSR--DKTIKVWDVETGKCLTTLRGhTDWVNSVAFSPD-GTFVAS-SS 154

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 19111873 357 AKNQVSLWKYPSLKNIANLTAHTNRVLYLSMSPDGQSIVTGAGDETLRFWKL 408
Cdd:cd00200 155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL 206
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 246-414 2.78e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.06  E-value: 2.78e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873 246 KVHEQEICGLQWDRSLGQLASGGNDNNLFVWDYRSSRPLHKFEEHTAAVKAIGWSPHQRGILASGGgtiDRCLTIhntlt 325
Cdd:cd00200   6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSS---DKTIRL----- 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873 326 grlqnkldtgsqvcnmaWSKTSNEIVTThgfaknqvslwkypslknianLTAHTNRVLYLSMSPDGQSIVTGAGDETLRF 405
Cdd:cd00200  78 -----------------WDLETGECVRT---------------------LTGHTSYVSSVAFSPDGRILSSSSRDKTIKV 119


                ....*....
gi 19111873 406 WKLFNKKPK 414
Cdd:cd00200 120 WDVETGKCL 128
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 156-219 2.64e-06

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 45.35  E-value: 2.64e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19111873   156 KVVQLHDFGATNHVTSVLWTGKGTQLAVGTDSGVIYIWDIESTKSVRSLKGHSERVAALAWNDN 219
Cdd:pfam12894  28 RVWTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWGEN 91
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 157-297 7.12e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.16  E-value: 7.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873  157 VVQLhdfGATNHVTSVLWTGK-GTQLAVGTDSGVIYIWDIESTKSVRSLKGHSERVAALAWN--DNTLTSGGKDEVILHH 233
Cdd:PLN00181 526 VVEL---ASRSKLSGICWNSYiKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSsaDPTLLASGSDDGSVKL 602

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19111873  234 DLRAPGCCAEMMKVhEQEICGLQWDRSLGQ-LASGGNDNNLFVWDYRSSR-PLHKFEEHTAAVKAI 297
Cdd:PLN00181 603 WSINQGVSIGTIKT-KANICCVQFPSESGRsLAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVSYV 667
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 368-407 3.27e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 3.27e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 19111873    368 SLKNIANLTAHTNRVLYLSMSPDGQSIVTGAGDETLRFWK 407
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 251-408 4.29e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.85  E-value: 4.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873  251 EICGLQWDRSL-GQLASGGNDNNLFVWDYRSSRPLHKFEEHTAAVKAIGWSPHQRGILASGG--GTIDRCLTIHNTLTGR 327
Cdd:PLN00181 534 KLSGICWNSYIkSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSddGSVKLWSINQGVSIGT 613

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873  328 LQNKldtgSQVCNMAWSKTSNEIVtTHGFAKNQVSlwkYPSLKN----IANLTAHTNRVLYLSMSpDGQSIVTGAGDETL 403
Cdd:PLN00181 614 IKTK----ANICCVQFPSESGRSL-AFGSADHKVY---YYDLRNpklpLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTL 684


                 ....*
gi 19111873  404 RFWKL 408
Cdd:PLN00181 685 KLWDL 689
PTZ00421 PTZ00421
coronin; Provisional
 179-293 7.82e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.88  E-value: 7.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873  179 TQLAVGTDSGVIYIWDIES---TKSVRS----LKGHSERVAALAWN---DNTLTSGGKDEVILHHDLRApGCCAEMMKVH 248
Cdd:PTZ00421  89 QKLFTASEDGTIMGWGIPEeglTQNISDpivhLQGHTKKVGIVSFHpsaMNVLASAGADMVVNVWDVER-GKAVEVIKCH 167

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 19111873  249 EQEICGLQWDRSLGQLASGGNDNNLFVWDYRSSRPLHKFEEHTAA 293
Cdd:PTZ00421 168 SDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASA 212
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 336-419 1.00e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.86  E-value: 1.00e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19111873 336 SQVCNMAWSKTSNEIVTthGFAKNQVSLWKYPSLKNIANLTAHTNRVLYLSMSPDGQSIVTGAGDETLRFWKLfnKKPKE 415
Cdd:cd00200  10 GGVTCVAFSPDGKLLAT--GSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL--ETGEC 85


                ....
gi 19111873 416 ESTL 419
Cdd:cd00200  86 VRTL 89
WD40 pfam00400
WD domain, G-beta repeat;
370-406 1.38e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.38e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 19111873   370 KNIANLTAHTNRVLYLSMSPDGQSIVTGAGDETLRFW 406
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 238-277 3.27e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 3.27e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 19111873    238 PGCCAEMMKVHEQEICGLQWDRSLGQLASGGNDNNLFVWD 277
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
143-197 3.63e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.59  E-value: 3.63e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19111873 143 LASS-----IYLWSAASGKvvQLHDF-GATNHVTSVLWTGKGTQLAVGTDSGVIYIWDIES 197
Cdd:COG2319 345 LASGsddgtVRLWDLATGE--LLRTLtGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH