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Conserved domains on  [gi|1910257198|ref|WP_191078692|]
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malonic semialdehyde reductase [Stenotrophomonas sp. Br8]

Protein Classification

nitroreductase family protein( domain architecture ID 10012358)

nitroreductase family protein, similar to nitroreductase which catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles by using NAD(P)H as electron donor in an obligatory two-electron transfer and FMN as cofactor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK05365 PRK05365
malonic semialdehyde reductase; Provisional
 2-196 2.25e-129

malonic semialdehyde reductase; Provisional


:

Pssm-ID: 180040 [Multi-domain]  Cd Length: 195  Bit Score: 361.44  E-value: 2.25e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198   2 SHALDAAALDQLFRTARTQNAFLDKPVEDAQLHALYDLLKWAPTAANGSPARFVFVKSAEAKAKLAPALSEGNHNKTVAA 81
Cdd:PRK05365    1 SEALDDAALDQLFTEARTHNGWLDEPVSDEQLRELYDLVKWGPTSANCSPARFVFVRSAEAKERLRPALSEGNLAKTLAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198  82 PVTVIVAFDQDFHEKLPYLFPHTDAKAWFDGPREGRHEGAFRNGSLQGGYLILAARALGLDAGPMSGFDNAKVDEAFFAG 161
Cdd:PRK05365   81 PVTAIVAYDTEFHEHLPKLFPHADARSWFAGNPALAEETAFRNSSLQGAYLILAARALGLDAGPMSGFDAAAVDAEFFAG 160

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1910257198 162 TSIKSNFLVNLGYGDDSGLFPRLPRLSFDEAARIA 196
Cdd:PRK05365  161 TTWKSNFLVNIGYGDPAKLFPRLPRLSFDEACRIL 195
 
Name Accession Description Interval E-value
PRK05365 PRK05365
malonic semialdehyde reductase; Provisional
 2-196 2.25e-129

malonic semialdehyde reductase; Provisional


Pssm-ID: 180040 [Multi-domain]  Cd Length: 195  Bit Score: 361.44  E-value: 2.25e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198   2 SHALDAAALDQLFRTARTQNAFLDKPVEDAQLHALYDLLKWAPTAANGSPARFVFVKSAEAKAKLAPALSEGNHNKTVAA 81
Cdd:PRK05365    1 SEALDDAALDQLFTEARTHNGWLDEPVSDEQLRELYDLVKWGPTSANCSPARFVFVRSAEAKERLRPALSEGNLAKTLAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198  82 PVTVIVAFDQDFHEKLPYLFPHTDAKAWFDGPREGRHEGAFRNGSLQGGYLILAARALGLDAGPMSGFDNAKVDEAFFAG 161
Cdd:PRK05365   81 PVTAIVAYDTEFHEHLPKLFPHADARSWFAGNPALAEETAFRNSSLQGAYLILAARALGLDAGPMSGFDAAAVDAEFFAG 160

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1910257198 162 TSIKSNFLVNLGYGDDSGLFPRLPRLSFDEAARIA 196
Cdd:PRK05365  161 TTWKSNFLVNIGYGDPAKLFPRLPRLSFDEACRIL 195
RutE-like cd02148
nitroreductase similar to Escherichia coli RutE; A subfamily of the nitroreductase family ...
 9-193 1.98e-111

nitroreductase similar to Escherichia coli RutE; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. RutE is involved in the utilization of uracil as the sole nitrogen source; it appears to have the same function as YdfG, which reduces malonic semialdehyde to 3-hydroxypropionic acid.


Pssm-ID: 380323 [Multi-domain]  Cd Length: 186  Bit Score: 315.73  E-value: 1.98e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198   9 ALDQLFRTARTQNAFLDKPVEDAQLHALYDLLKWAPTAANGSPARFVFVKSAEAKAKLAPALSEGNHNKTVAAPVTVIVA 88
Cdd:cd02148     1 ALDQLFTEARTHNAWEDKPVSDEELRAIYDLAKWGPTAANCSPARIVFVRSAEAKERLVPHLSEGNREKTMAAPVTAILA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198  89 FDQDFHEKLPYLFPHTDAKAWF-DGPREGRHEGAFRNGSLQGGYLILAARALGLDAGPMSGFDNAKVDEAFFAGTSIKSN 167
Cdd:cd02148    81 YDTEFYEHLPRLFPHGDARSWFfGSGPARAEETAFRNASLQAAYFILAARALGLDCGPMSGFDAAGVDAEFFAGTRWKSN 160

                         170       180
                  ....*....|....*....|....*.
gi 1910257198 168 FLVNLGYGDDSGLFPRLPRLSFDEAA 193
Cdd:cd02148   161 LVVNLGYGDPSKLFPRLPRLDFDEAC 186
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 10-191 1.29e-43

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 143.07  E-value: 1.29e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198  10 LDQLFRTARTQNAFLDKPVEDAQLHALYDLLKWAPTAANGSPARFVFVKSAEAKAKLAPALSEGNHNKTVAAPVTVIVAF 89
Cdd:COG0778     1 LLELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPELRERLAEALAEANQEWVADAPVLIVVCA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198  90 DQDFHEKLPYLFphtdakawfdgpregrhegAFRNGSLQGGYLILAARALGLDAGPMSGFDNAKVDEAFFAGTSIKSNFL 169
Cdd:COG0778    81 DPDRSEKVPERY-------------------ALLDAGIAAQNLLLAARALGLGTCWIGGFDPEKVRELLGLPEGEEPVAL 141

                         170       180
                  ....*....|....*....|..
gi 1910257198 170 VNLGYGDDSgLFPRlPRLSFDE 191
Cdd:COG0778   142 LALGYPAEE-LNPR-PRKPLEE 161
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 15-158 8.99e-18

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 76.66  E-value: 8.99e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198  15 RTARTQNAFLDKPVEDAQLHALYDLLKWAPTAANGSPARFVFVKSAEAKAKLAPALSEGnhNKTVAAPVTVIVAFDQDFH 94
Cdd:pfam00881   2 RQRRSVRKFDPEPVPKEVLEEILEAARRAPSAGNLQPWRFYVVTDGELRYRLAEAALEL--LLVEPAAALLLLLRRDANL 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1910257198  95 EKLP---------YLFPHTDAKAWFDGPREGRHEGAFRNGSLQGGYLILAARALGLDAGPMSGFDNAKVDEAF 158
Cdd:pfam00881  80 KLLLqdflrgapvLIVITASLSTYLRKAAERAYREALLDAGAAAQNLLLAATSLGLGSCPIGGFDAAAVRELL 152
 
Name Accession Description Interval E-value
PRK05365 PRK05365
malonic semialdehyde reductase; Provisional
 2-196 2.25e-129

malonic semialdehyde reductase; Provisional


Pssm-ID: 180040 [Multi-domain]  Cd Length: 195  Bit Score: 361.44  E-value: 2.25e-129
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198   2 SHALDAAALDQLFRTARTQNAFLDKPVEDAQLHALYDLLKWAPTAANGSPARFVFVKSAEAKAKLAPALSEGNHNKTVAA 81
Cdd:PRK05365    1 SEALDDAALDQLFTEARTHNGWLDEPVSDEQLRELYDLVKWGPTSANCSPARFVFVRSAEAKERLRPALSEGNLAKTLAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198  82 PVTVIVAFDQDFHEKLPYLFPHTDAKAWFDGPREGRHEGAFRNGSLQGGYLILAARALGLDAGPMSGFDNAKVDEAFFAG 161
Cdd:PRK05365   81 PVTAIVAYDTEFHEHLPKLFPHADARSWFAGNPALAEETAFRNSSLQGAYLILAARALGLDAGPMSGFDAAAVDAEFFAG 160

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1910257198 162 TSIKSNFLVNLGYGDDSGLFPRLPRLSFDEAARIA 196
Cdd:PRK05365  161 TTWKSNFLVNIGYGDPAKLFPRLPRLSFDEACRIL 195
RutE-like cd02148
nitroreductase similar to Escherichia coli RutE; A subfamily of the nitroreductase family ...
 9-193 1.98e-111

nitroreductase similar to Escherichia coli RutE; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. RutE is involved in the utilization of uracil as the sole nitrogen source; it appears to have the same function as YdfG, which reduces malonic semialdehyde to 3-hydroxypropionic acid.


Pssm-ID: 380323 [Multi-domain]  Cd Length: 186  Bit Score: 315.73  E-value: 1.98e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198   9 ALDQLFRTARTQNAFLDKPVEDAQLHALYDLLKWAPTAANGSPARFVFVKSAEAKAKLAPALSEGNHNKTVAAPVTVIVA 88
Cdd:cd02148     1 ALDQLFTEARTHNAWEDKPVSDEELRAIYDLAKWGPTAANCSPARIVFVRSAEAKERLVPHLSEGNREKTMAAPVTAILA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198  89 FDQDFHEKLPYLFPHTDAKAWF-DGPREGRHEGAFRNGSLQGGYLILAARALGLDAGPMSGFDNAKVDEAFFAGTSIKSN 167
Cdd:cd02148    81 YDTEFYEHLPRLFPHGDARSWFfGSGPARAEETAFRNASLQAAYFILAARALGLDCGPMSGFDAAGVDAEFFAGTRWKSN 160

                         170       180
                  ....*....|....*....|....*.
gi 1910257198 168 FLVNLGYGDDSGLFPRLPRLSFDEAA 193
Cdd:cd02148   161 LVVNLGYGDPSKLFPRLPRLDFDEAC 186
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 10-191 1.29e-43

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 143.07  E-value: 1.29e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198  10 LDQLFRTARTQNAFLDKPVEDAQLHALYDLLKWAPTAANGSPARFVFVKSAEAKAKLAPALSEGNHNKTVAAPVTVIVAF 89
Cdd:COG0778     1 LLELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPELRERLAEALAEANQEWVADAPVLIVVCA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198  90 DQDFHEKLPYLFphtdakawfdgpregrhegAFRNGSLQGGYLILAARALGLDAGPMSGFDNAKVDEAFFAGTSIKSNFL 169
Cdd:COG0778    81 DPDRSEKVPERY-------------------ALLDAGIAAQNLLLAARALGLGTCWIGGFDPEKVRELLGLPEGEEPVAL 141

                         170       180
                  ....*....|....*....|..
gi 1910257198 170 VNLGYGDDSgLFPRlPRLSFDE 191
Cdd:COG0778   142 LALGYPAEE-LNPR-PRKPLEE 161
Nitro_FMN_reductase cd02062
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 14-174 3.03e-21

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380311 [Multi-domain]  Cd Length: 139  Bit Score: 84.66  E-value: 3.03e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198  14 FRTARTQNAFLDKPVEDAQLHALYDLLKWAPTAANGSPARFVFVKSAEAKAKLAPALSEGNhNKTVAAPVTVIVAFDQDF 93
Cdd:cd02062     1 IKTRRSIRKFTDKPVPEEKLRKILEAARLAPSAGNLQPWRFIVVRDREKKEKLAKLAAPNQ-KFIAGAPVVIVVVADPDK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198  94 HEklpylfphtdakawfdgpregrhEGAFRNGSLQGGYLILAARALGLDAGPMSGFD--NAKVDEAFFAGTSIKSNFLVN 171
Cdd:cd02062    80 SR-----------------------PWALEDAGAAAQNLLLAAAALGLGSCWIGGFDfrEDKVRELLGIPENLRPVALIA 136


                  ...
gi 1910257198 172 LGY 174
Cdd:cd02062   137 IGY 139
MhqN-like cd02137
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily ...
 25-191 5.06e-19

nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily of the nitroreductase family containing uncharacterized proteins; includes nitroreductases MhqN, YodC, YdgI, DrgA. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380314 [Multi-domain]  Cd Length: 147  Bit Score: 79.21  E-value: 5.06e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198  25 DKPVEDAQLHALYDLLKWAPTAANGSPARFVFVKSAEAKAKLAPALseGNHNKTVAAPVTVIVAFDQdfheklpylfpht 104
Cdd:cd02137    16 DHKIPKEELKEILELATLAPSSFNLQPWRFVVVRDPELKAKLAEAA--YNQPQVTTASAVILVLGDL------------- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198 105 dakawfdgpregrhegafrNGSLQGGYLILAARALGLDAGPMSGFDNAKVDEAFfagtSIKSNFLVNL----GYGDDSGl 180
Cdd:cd02137    81 -------------------NAGLAAMNLMLAAKAKGYDTCPMGGFDKEKVAELL----NLPDRYVPVLliaiGKAADKA- 136

                         170
                  ....*....|.
gi 1910257198 181 fPRLPRLSFDE 191
Cdd:cd02137   137 -PRSGRLPVDE 146
nitroreductase cd03370
uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus ...
 15-179 3.43e-18

uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus thermophilus NADH oxidase and other, uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380327 [Multi-domain]  Cd Length: 191  Bit Score: 78.13  E-value: 3.43e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198  15 RTARTQNAFLDKPVEDAQLHALYDLLKWAPTAANGSPARFVFVKSAEAKAKLAPALSegNHNKTVAAPVTVIVAFD---- 90
Cdd:cd03370     6 ESRRSIRKYTQEPVPDEDLREILRLAGLAPSAWNIQPWRFVVVRDAELKEQLQAAAY--GQAQVTSAPAVIVIYSDmeda 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198  91 -QDFHEKLPYLFPHtDAKAWfdgpREGRHEGAFRN---------GSLQG----GYLILAARALGLDAGPMSGFDNAKVDE 156
Cdd:cd03370    84 lANLEETIHPGLSE-ERRQR----EAAGLRGAFGKmsveqrgqwGLAQAnialGFLLLAAQSLGYDTSPMLGFDPEKVKA 158

                         170       180
                  ....*....|....*....|...
gi 1910257198 157 AFFAGTSIKSNFLVNLGYGDDSG 179
Cdd:cd03370   159 LLGLPEHVTIAALVALGKPAEEG 181
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 15-158 8.99e-18

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 76.66  E-value: 8.99e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198  15 RTARTQNAFLDKPVEDAQLHALYDLLKWAPTAANGSPARFVFVKSAEAKAKLAPALSEGnhNKTVAAPVTVIVAFDQDFH 94
Cdd:pfam00881   2 RQRRSVRKFDPEPVPKEVLEEILEAARRAPSAGNLQPWRFYVVTDGELRYRLAEAALEL--LLVEPAAALLLLLRRDANL 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1910257198  95 EKLP---------YLFPHTDAKAWFDGPREGRHEGAFRNGSLQGGYLILAARALGLDAGPMSGFDNAKVDEAF 158
Cdd:pfam00881  80 KLLLqdflrgapvLIVITASLSTYLRKAAERAYREALLDAGAAAQNLLLAATSLGLGSCPIGGFDAAAVRELL 152
TdsD-like cd02138
nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase ...
 22-158 5.03e-15

nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to Burkholderia pseudomallei TdsD, may be involved in the processing of organosulfur compounds. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380315 [Multi-domain]  Cd Length: 174  Bit Score: 69.50  E-value: 5.03e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198  22 AFLDKPVEDAQLHALYDLLKWAPTAANGSPARFVFV-KSAEAKAKLAPALSEGNHNKTVAAPVTVIVAFDQDFHEKlpyl 100
Cdd:cd02138    10 AFSPEPISEEDLLSLFEAARWAPSCFNEQPWRFVVArRDTEAFEKLLDLLAEGNQSWAKNAPVLIVVLAKTEFDHN---- 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1910257198 101 fPHTDAKAWFDgpregrhEGAFRngslqgGYLILAARALGLDAGPMSGFDNAKVDEAF 158
Cdd:cd02138    86 -GKPNRYALFD-------TGAAV------ANLALQATALGLVVHQMAGFDPEKAKEAL 129
nitroreductase cd20609
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 23-158 4.78e-14

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380330 [Multi-domain]  Cd Length: 145  Bit Score: 66.26  E-value: 4.78e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198  23 FLDKPVEDAQLHALYDLLKWAPTAANGSPARFVFVKSAEAKAKLAPAlsegnHNKTVAAPVTVIVAFDQDfheklpylfp 102
Cdd:cd20609    15 FSDKPVEKEKLDKILEAGRLAPTAVNYQPQRILVVRSEEALEKLAKA-----TPRFFGAPLVIVVCYDKD---------- 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1910257198 103 htdaKAWFDgPREGRHEG---AfrngSLQGGYLILAARALGLDAGPMSGFDNAKVDEAF 158
Cdd:cd20609    80 ----ESWKR-PYDGKDSGdidA----AIVATHMMLAATELGLGTCWVGNFDPEKVREAF 129
NfsB-like cd02149
nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This ...
 26-159 7.93e-13

nitroreductase similar to Escherichia coli NfsB; NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family includes FRase I in Vibrio fischeri, wihich reduces FMN into FMNH2 as part of the bioluminescent reaction. The family also includes oxygen-insensitive nitroreductases that use NADH or NADPH as an electron donor in the ping pong bi bi mechanism. This type of nitroreductase can be used in cancer chemotherapy to activate a range of prodrugs.


Pssm-ID: 380324 [Multi-domain]  Cd Length: 156  Bit Score: 63.04  E-value: 7.93e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198  26 KPVEDAQLHALYDLLKWAPTAANGSPARFVFVKSAEAKAKLAPALSeGNHNKTVAAPVTVIVAFDQDFHEKLPYlfphtd 105
Cdd:cd02149    19 KKISDEDLETILEALRLSPSSFGLEPWKFLVVENPELKAKLAPAAW-FNQPQIKDASHVVVFLAKKDWSAKQTY------ 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1910257198 106 akawfdgpregrhegafrngsLQGGYLILAARALGLDAGPMSGFDNAKVDEAFF 159
Cdd:cd02149    92 ---------------------IALGNMLLAAAMLGIDSCPIEGFDPAKLDEILG 124
PRK11053 PRK11053
oxygen-insensitive NAD(P)H nitroreductase;
26-186 2.65e-12

oxygen-insensitive NAD(P)H nitroreductase;


Pssm-ID: 182929 [Multi-domain]  Cd Length: 217  Bit Score: 63.07  E-value: 2.65e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198  26 KPVEDAQLHALYDLLKWAPTAANGSPARFVFVKSAEAKAKLAPALSEG---NHNKTVAAPVTVI----VAFDQDFHEKLp 98
Cdd:PRK11053   20 KKLPAEQIEQIKTLLRFSPSSVNSQPWHFIVASTEEGKARIAKAAAGNyafNERKILDASHVVVfcakTDMDDAYLELV- 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198  99 yL--------FPHTDAKAwfdGPREGRH--EGAFRNG--SLQG----------GYLILAARALGLDAGPMSGFDNAKVDE 156
Cdd:PRK11053   99 -LeqedadgrFATEEAKA---AQDKGRRffADMHRKElkDLQHwmekqvylalGNLLLGAAALGIDATPIEGFDAAILDA 174

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1910257198 157 AF-FAGTSIKSNFLVNLGYGDDSGLFPRLPR 186
Cdd:PRK11053  175 EFgLREKGLTSSVVVPLGYHSEEDFNAKLPK 205
nitroreductase cd20608
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 15-174 2.09e-10

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380329 [Multi-domain]  Cd Length: 145  Bit Score: 56.57  E-value: 2.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198  15 RTARTQNAFLDKPVEDAQLHALYDLLKWAPTAANGSPARFVFVKSAEAKAKLapALSEGNHNKTVA-APVTVIVAFDqdf 93
Cdd:cd20608     5 KTRRSVRRFSDKPVEEEKLEKILEAARLAPSWANKQCWRFIVVTDKETLSEL--AKKESPSNGWLKdAPVIIVVCAD--- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198  94 heklpylfphtdakawfdgPRE-GRHEG----------AFRNgslqggyLILAARALGLDAGPMSGFDNAKVDEAFfagt 162
Cdd:cd20608    80 -------------------PKDsGWLNGqnyylvdaaiAMQN-------LMLAATDLGLGTCWIGAFDEKKVKEIL---- 129

                         170
                  ....*....|....*.
gi 1910257198 163 SIKSNF----LVNLGY 174
Cdd:cd20608   130 GIPENIrvvaLTPLGY 145
PnbA_NfnB-like cd02136
nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as ...
 22-191 7.55e-09

nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.


Pssm-ID: 380313 [Multi-domain]  Cd Length: 152  Bit Score: 52.21  E-value: 7.55e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198  22 AFLDKPVEDAQLHALYDLLKWAPTAANGSPARFVFVKSaEAKAKLAPALsegnhnktVAAPVTVIVAFDQDfheklpylf 101
Cdd:cd02136    10 AFKDKPVPKETIEKILEAARRAPSGKNTQPWRVYVVTG-KARERLKKAF--------FGAPVALFLTMDKV--------- 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198 102 phTDAKAWFDGpregrheGAFrngsLQGgyLILAARALGLDAGPMSGF--DNAKVDEAFFAGTSIKSNFLVNLGYGDDSG 179
Cdd:cd02136    72 --LGPWSWFDL-------GAF----LQN--LMLAAHALGLGTCPQGALagYPDVVRKELGIPDDEELVCGIALGYPDPDA 136

                         170
                  ....*....|....
gi 1910257198 180 LF--PRLPRLSFDE 191
Cdd:cd02136   137 PVnqFRTPREPLEE 150
nitroreductase cd02139
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 22-191 3.05e-08

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380316 [Multi-domain]  Cd Length: 165  Bit Score: 50.93  E-value: 3.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198  22 AFLDKPVEDAQLHALYDLLKWAPTAANGSPARFVFVKSAEAKAKLAPALsegNHNKTVA-APVT-VIVAfdqdfhekLPY 99
Cdd:cd02139    13 KYKPTPVEEEKLLRILEAARLAPSAKNRQPWRFIVVKDKELKEKLAEAA---NGQKFIAeAPVViVACA--------DPS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198 100 LFPHTDAKAWF--DgpregrhegafrnGSLQGGYLILAARALGLDAGPMSGFDNAKVDEAFfagtSIKSNF----LVNLG 173
Cdd:cd02139    82 ESGMGCGKPYYlvD-------------VAIAMEHLVLAATEEGLGTCWIGAFDEDKVKEIL----GIPEEYrvvaLTPLG 144

                         170
                  ....*....|....*...
gi 1910257198 174 YGDDSGLfPRlPRLSFDE 191
Cdd:cd02139   145 YPAEEPP-PR-PRKPLEE 160
nitroreductase cd02150
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 14-143 2.11e-06

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380325 [Multi-domain]  Cd Length: 156  Bit Score: 45.67  E-value: 2.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198  14 FRTARTQNAFLDKPVEDAQLHALYDLLKWAPTAANGSPARFVFVKSAEAKAKLAPALSEGNHNKTvaAPVTVIVAFDQDF 93
Cdd:cd02150     1 ILTRRSIRKYTDKPVEEEDIEKLLRAAMAAPSAGNQQPWHFIVVTDREKLDKIAEAHPYGKMLKE--APLAIVVCGDPSK 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1910257198  94 HEKLPYLFphTDAKAwfdgpregrhegAFRNgslqggyLILAARALGLDA 143
Cdd:cd02150    79 EKAPGYWV--QDCSA------------ATEN-------ILLAAHALGLGA 107
NfsA-like cd02146
nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin ...
 18-141 5.90e-05

nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.


Pssm-ID: 380322 [Multi-domain]  Cd Length: 229  Bit Score: 42.22  E-value: 5.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198  18 RTQNAFLDKPVEDAQLHALYDLLKWAPTAANGSPARFVFVKSAEAKAKLAPAlsEGNHNKTVAAPVTVIvaFDQDFH--- 94
Cdd:cd02146     9 RSVRKFTDEPLTDETLETLIAAAQSASTSSNLQAYSVIVVTDPELREKLAEL--AGNQPYVAQAPVFLV--FCADLYrhq 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1910257198  95 ----EKLPYLFPHTDAKAWFDGpregrhegaFRNGSLQGGYLILAARALGL 141
Cdd:cd02146    85 kiaeEAGGKDVGLDYLESFLVG---------VVDAALAAQNALVAAESLGL 126
nitroreductase_FeS-like cd02143
nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family ...
 13-67 1.13e-04

nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family utilize FMN as a cofactor. This family may be involved in the reduction of flavin or nitroaromatic compounds via an obligatory two-electron transfer. Nitroreductase is homodimer. Each subunit contains one FMN molecule.


Pssm-ID: 380319 [Multi-domain]  Cd Length: 187  Bit Score: 40.92  E-value: 1.13e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1910257198  13 LFRTARTQNAFLDKPVEDAQLHALYDLLKWAPTAANGSPARFVFVKSAEAKAKLA 67
Cdd:cd02143     1 LLRSRRSIRRYKDKPVPRETLEKLLDIARYAPTGHNSQPVHWLVVDDPEKVRRLA 55
nitroreductase cd02151
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 12-141 8.28e-04

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers..


Pssm-ID: 380326 [Multi-domain]  Cd Length: 157  Bit Score: 38.28  E-value: 8.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1910257198  12 QLFRTARTQNAFLDKPVEDAQLHALYDLLKWAPTAANGSPARFVFVKSAEAKAKLAPALSEGnhNKTVA-APVTVIVAFD 90
Cdd:cd02151     1 ELLKKRRSIRKYTDEPIEEEKLEEILEAALLAPSSRNSRPVEFIVVDDKETLKKLSECKPHG--SAFLKgAPAAIVVLAD 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1910257198  91 QDfheklpylfphtDAKAWfdgpREgrhegafrNGSLQGGYLILAARALGL 141
Cdd:cd02151    79 TE------------KSDTW----IE--------DASIAATYIQLAAESLGL 105
nitroreductase cd20610
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 23-67 1.96e-03

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380331 [Multi-domain]  Cd Length: 167  Bit Score: 37.26  E-value: 1.96e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1910257198  23 FLDKPVEDAQLHALYDLLKWAPTAANGSPARFVFVKSAEAKAKLA 67
Cdd:cd20610    10 FKPDPVPKEDIEKILEAANWAPSGMNRQNWEFVVVKGGEKIEKIG 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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