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Conserved domains on  [gi|1909765275|ref|WP_190646253|]
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MULTISPECIES: circadian clock protein KaiB [Cyanophyceae]

Protein Classification

similar to circadian clock protein KaiB( domain architecture ID 10793189)

protein similar to circadian clock protein KaiB

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK09301 PRK09301
circadian clock protein KaiB; Provisional
 2-94 7.41e-59

circadian clock protein KaiB; Provisional


:

Pssm-ID: 181770  Cd Length: 103  Bit Score: 175.76  E-value: 7.41e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1909765275   2 SPLKKTYILKLYVAGNTPNSIRALKTLNNILEKEFQGVYALKVIDVLKNPQLAEEDKILATPTLSKILPPPVRKIIGDLS 81
Cdd:PRK09301    1 MSPRKTYILKLYVAGNTPNSVRALKTLKNILETEFKGVYALKVIDVLKNPQLAEEDKILATPTLAKILPPPVRKIIGDLS 80

                          90
                  ....*....|...
gi 1909765275  82 DREKVLIGLDLLY 94
Cdd:PRK09301   81 DREKVLIGLDLLY 93
 
Name Accession Description Interval E-value
PRK09301 PRK09301
circadian clock protein KaiB; Provisional
 2-94 7.41e-59

circadian clock protein KaiB; Provisional


Pssm-ID: 181770  Cd Length: 103  Bit Score: 175.76  E-value: 7.41e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1909765275   2 SPLKKTYILKLYVAGNTPNSIRALKTLNNILEKEFQGVYALKVIDVLKNPQLAEEDKILATPTLSKILPPPVRKIIGDLS 81
Cdd:PRK09301    1 MSPRKTYILKLYVAGNTPNSVRALKTLKNILETEFKGVYALKVIDVLKNPQLAEEDKILATPTLAKILPPPVRKIIGDLS 80

                          90
                  ....*....|...
gi 1909765275  82 DREKVLIGLDLLY 94
Cdd:PRK09301   81 DREKVLIGLDLLY 93
circ_KaiB TIGR02654
circadian clock protein KaiB; Members of this protein family are the circadian clock protein ...
 5-91 1.87e-52

circadian clock protein KaiB; Members of this protein family are the circadian clock protein KaiB of Cyanobacteria, encoded in the circadian clock gene cluster kaiABC. KaiB has homologs of unknown function in some Archaea and Proteobacteria, and has paralogs of unknown function in some Cyanobacteria. KaiB forms homodimers, homotetramers, and multimeric complexes with KaiA and/or KaiC. [Cellular processes, Other]


Pssm-ID: 211759  Cd Length: 87  Bit Score: 159.36  E-value: 1.87e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1909765275   5 KKTYILKLYVAGNTPNSIRALKTLNNILEKEFQGVYALKVIDVLKNPQLAEEDKILATPTLSKILPPPVRKIIGDLSDRE 84
Cdd:TIGR02654   1 RKTYVLKLYVAGNTPNSVRALKTLKNILETEFQGVYALKVIDVLKNPQLAEEDKILATPTLSKILPPPVRKIIGDLSDRE 80


                  ....*..
gi 1909765275  85 KVLIGLD 91
Cdd:TIGR02654  81 RVLIGLD 87
KaiB_like cd02978
KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like ...
 7-78 8.33e-33

KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part of the circadian clock gene cluster, kaiABC. KaiB attenuates KaiA-enhanced KaiC autokinase activity by interacting with KaiA-KaiC complexes in a circadian fashion. KaiB is membrane-associated as well as cytosolic. The amount of membrane-associated protein peaks in the evening (at circadian time (CT) 12-16) while the cytosolic form peaks later (at CT 20). The rhythmic localization of KaiB may function in regulating the formation of Kai complexes. SasA is a sensory histidine kinase which associates with KaiC. Although it is not an essential oscillator component, it is important in enhancing kaiABC expression and is important in metabolic growth control under day/night cycle conditions. SasA contains an N-terminal sensory domain with a TRX fold which is involved in the SasA-KaiC interaction. This domain shows high sequence similarity with KaiB. However, the KaiB structure does not show a classical TRX fold. The N-terminal half of KaiB shares the same beta-alpha-beta topology as TRX, but the topology of its C-terminal half diverges.


Pssm-ID: 239276  Cd Length: 72  Bit Score: 108.83  E-value: 8.33e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1909765275   7 TYILKLYVAGNTPNSIRALKTLNNILEKEFQGVYALKVIDVLKNPQLAEEDKILATPTLSKILPPPVRKIIG 78
Cdd:cd02978     1 RYVLRLYVAGRTPKSERALQNLKRILEELLGGPYELEVIDVLKQPQLAEEDKIVATPTLVKVLPPPRRRLIG 72
KaiB pfam07689
KaiB domain; The cyanobacterial clock proteins KaiA and KaiB are proposed as regulators of the ...
 11-92 4.53e-32

KaiB domain; The cyanobacterial clock proteins KaiA and KaiB are proposed as regulators of the circadian rhythm in cyanobacteria. Mutations in both proteins have been reported to alter or abolish circadian rhythmicity. KaiB adopts an alpha-beta meander motif and is found to be a dimer.


Pssm-ID: 400160  Cd Length: 82  Bit Score: 107.40  E-value: 4.53e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1909765275  11 KLYVAGNTPNSIRALKTLNNILEKEFQGVYALKVIDVLKNPQLAEEDKILATPTLSKILPPPVRKIIGDLSDREKVLIGL 90
Cdd:pfam07689   1 LLYVAGRPLSSERALENLQDLLEEDLGFPYELQVIDVLEQPELAEEDRLVATPTLIKLLPEPRQRLAGDLSNQQLVNWLL 80


                  ..
gi 1909765275  91 DL 92
Cdd:pfam07689  81 RW 82
 
Name Accession Description Interval E-value
PRK09301 PRK09301
circadian clock protein KaiB; Provisional
 2-94 7.41e-59

circadian clock protein KaiB; Provisional


Pssm-ID: 181770  Cd Length: 103  Bit Score: 175.76  E-value: 7.41e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1909765275   2 SPLKKTYILKLYVAGNTPNSIRALKTLNNILEKEFQGVYALKVIDVLKNPQLAEEDKILATPTLSKILPPPVRKIIGDLS 81
Cdd:PRK09301    1 MSPRKTYILKLYVAGNTPNSVRALKTLKNILETEFKGVYALKVIDVLKNPQLAEEDKILATPTLAKILPPPVRKIIGDLS 80

                          90
                  ....*....|...
gi 1909765275  82 DREKVLIGLDLLY 94
Cdd:PRK09301   81 DREKVLIGLDLLY 93
circ_KaiB TIGR02654
circadian clock protein KaiB; Members of this protein family are the circadian clock protein ...
 5-91 1.87e-52

circadian clock protein KaiB; Members of this protein family are the circadian clock protein KaiB of Cyanobacteria, encoded in the circadian clock gene cluster kaiABC. KaiB has homologs of unknown function in some Archaea and Proteobacteria, and has paralogs of unknown function in some Cyanobacteria. KaiB forms homodimers, homotetramers, and multimeric complexes with KaiA and/or KaiC. [Cellular processes, Other]


Pssm-ID: 211759  Cd Length: 87  Bit Score: 159.36  E-value: 1.87e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1909765275   5 KKTYILKLYVAGNTPNSIRALKTLNNILEKEFQGVYALKVIDVLKNPQLAEEDKILATPTLSKILPPPVRKIIGDLSDRE 84
Cdd:TIGR02654   1 RKTYVLKLYVAGNTPNSVRALKTLKNILETEFQGVYALKVIDVLKNPQLAEEDKILATPTLSKILPPPVRKIIGDLSDRE 80


                  ....*..
gi 1909765275  85 KVLIGLD 91
Cdd:TIGR02654  81 RVLIGLD 87
KaiB_like cd02978
KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like ...
 7-78 8.33e-33

KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part of the circadian clock gene cluster, kaiABC. KaiB attenuates KaiA-enhanced KaiC autokinase activity by interacting with KaiA-KaiC complexes in a circadian fashion. KaiB is membrane-associated as well as cytosolic. The amount of membrane-associated protein peaks in the evening (at circadian time (CT) 12-16) while the cytosolic form peaks later (at CT 20). The rhythmic localization of KaiB may function in regulating the formation of Kai complexes. SasA is a sensory histidine kinase which associates with KaiC. Although it is not an essential oscillator component, it is important in enhancing kaiABC expression and is important in metabolic growth control under day/night cycle conditions. SasA contains an N-terminal sensory domain with a TRX fold which is involved in the SasA-KaiC interaction. This domain shows high sequence similarity with KaiB. However, the KaiB structure does not show a classical TRX fold. The N-terminal half of KaiB shares the same beta-alpha-beta topology as TRX, but the topology of its C-terminal half diverges.


Pssm-ID: 239276  Cd Length: 72  Bit Score: 108.83  E-value: 8.33e-33
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1909765275   7 TYILKLYVAGNTPNSIRALKTLNNILEKEFQGVYALKVIDVLKNPQLAEEDKILATPTLSKILPPPVRKIIG 78
Cdd:cd02978     1 RYVLRLYVAGRTPKSERALQNLKRILEELLGGPYELEVIDVLKQPQLAEEDKIVATPTLVKVLPPPRRRLIG 72
KaiB pfam07689
KaiB domain; The cyanobacterial clock proteins KaiA and KaiB are proposed as regulators of the ...
 11-92 4.53e-32

KaiB domain; The cyanobacterial clock proteins KaiA and KaiB are proposed as regulators of the circadian rhythm in cyanobacteria. Mutations in both proteins have been reported to alter or abolish circadian rhythmicity. KaiB adopts an alpha-beta meander motif and is found to be a dimer.


Pssm-ID: 400160  Cd Length: 82  Bit Score: 107.40  E-value: 4.53e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1909765275  11 KLYVAGNTPNSIRALKTLNNILEKEFQGVYALKVIDVLKNPQLAEEDKILATPTLSKILPPPVRKIIGDLSDREKVLIGL 90
Cdd:pfam07689   1 LLYVAGRPLSSERALENLQDLLEEDLGFPYELQVIDVLEQPELAEEDRLVATPTLIKLLPEPRQRLAGDLSNQQLVNWLL 80


                  ..
gi 1909765275  91 DL 92
Cdd:pfam07689  81 RW 82
PRK09303 PRK09303
histidine kinase;
12-72 2.74e-07

histidine kinase;


Pssm-ID: 236462 [Multi-domain]  Cd Length: 380  Bit Score: 46.87  E-value: 2.74e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1909765275  12 LYVAGNTPNSIRALKTLNNILEKEFQGV-YALKVIDVLKNPQLAEEDKILATPTLSKILPPP 72
Cdd:PRK09303   18 LLFADRRPLSREDIQRIIAYLESLDCGFpISLQIIDPGEQPELLELFRLVATPALIKISPEP 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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