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Conserved domains on  [gi|1907154766|ref|XP_036019711|]
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protein FAN isoform X4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Beach pfam02138
Beige/BEACH domain;
39-186 2.76e-84

Beige/BEACH domain;


:

Pssm-ID: 460459  Cd Length: 277  Bit Score: 262.80  E-value: 2.76e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766  39 IAETWKNCLDGATDFKELIPEFYDeDVSFLVNSLKLDLGKRQGGQMVDDVDLPAWA-SSPQDFLQKNKDALESGYVSEHL 117
Cdd:pfam02138 130 IEEAWRSASNSTSDVKELIPEFFY-LPEFLLNSNNFDLGGRQDGEKVDDVELPPWAkKSPEEFVRKHREALESDYVSENL 208

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907154766 118 HEWIDLIFGYKQKGSEAIGAHNVFHPLTYEGGVDLNSIEDPDEKVAMLTQILEFGQTPKQLFVTPHPRR 186
Cdd:pfam02138 209 HEWIDLIFGYKQRGEEAVEALNVFHPLTYEGSVDLDSIKDPVERDAIEAQIKNFGQTPKQLFTKPHPPR 277
WD40 COG2319
WD40 repeat [General function prediction only];
230-537 2.20e-43

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 158.92  E-value: 2.20e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 230 NIAKLQLHEQYKIHKEAVTGIAVSCNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDTTVISSSWDNN 309
Cdd:COG2319   106 DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 310 VYFYSIAFGRRQDTLMGHDDAVSKICWHND--RLYSGSWDSTVKVWSgvpaemPGTKRhqfdLLAELEHDVSMtyllekV 387
Cdd:COG2319   186 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDgkLLASGSADGTVRLWD------LATGK----LLRTLTGHSGS------V 249

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 388 NTINLNAVSTLLVSGTKEGMVNIWDLTTATLLHQTSCHSGTVCDAAFSPDSRHILSTGVDGCLNVIDVQTGMLISSM-AS 466
Cdd:COG2319   250 RSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLtGH 329

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907154766 467 EEPQRCFVW--DGNSVLSGSRSGELLVWDLLGAKVSERIQGHTGAVTCMWMNEQCSSIITGGEDRQIMFWKLQ 537
Cdd:COG2319   330 TGAVRSVAFspDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
Beach pfam02138
Beige/BEACH domain;
39-186 2.76e-84

Beige/BEACH domain;


Pssm-ID: 460459  Cd Length: 277  Bit Score: 262.80  E-value: 2.76e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766  39 IAETWKNCLDGATDFKELIPEFYDeDVSFLVNSLKLDLGKRQGGQMVDDVDLPAWA-SSPQDFLQKNKDALESGYVSEHL 117
Cdd:pfam02138 130 IEEAWRSASNSTSDVKELIPEFFY-LPEFLLNSNNFDLGGRQDGEKVDDVELPPWAkKSPEEFVRKHREALESDYVSENL 208

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907154766 118 HEWIDLIFGYKQKGSEAIGAHNVFHPLTYEGGVDLNSIEDPDEKVAMLTQILEFGQTPKQLFVTPHPRR 186
Cdd:pfam02138 209 HEWIDLIFGYKQRGEEAVEALNVFHPLTYEGSVDLDSIKDPVERDAIEAQIKNFGQTPKQLFTKPHPPR 277
Beach smart01026
Beige/BEACH domain; The BEACH domain was described in the BEIGE protein (D1035670) and in the ...
 39-186 6.13e-84

Beige/BEACH domain; The BEACH domain was described in the BEIGE protein (D1035670) and in the highly homologous CHS protein. The BEACH domain is usually followed by a series of WD repeats. The function of the BEACH domain is unknown.


Pssm-ID: 214982  Cd Length: 280  Bit Score: 262.16  E-value: 6.13e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766   39 IAETWKNC-LDGATDFKELIPEFYDeDVSFLVNSLKLDLGKRQGGQMVDDVDLPAWA-SSPQDFLQKNKDALESGYVSEH 116
Cdd:smart01026 132 VAATWRSAsLESMTDVKELIPEFFY-LPEFLVNINGFDFGTRQDGEDVDDVELPPWAkGSPEEFIRKHREALESEYVSQH 210

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766  117 LHEWIDLIFGYKQKGSEAIGAHNVFHPLTYEGGVDLNSIEDPDEKVAMLTQILEFGQTPKQLFVTPHPRR 186
Cdd:smart01026 211 LHHWIDLIFGYKQRGKEAVEALNVFHPLTYEGAVDLDSIEDPVERKALEGQIHNFGQTPKQLFKEPHPPR 280
Beach cd06071
BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in ...
 39-186 9.77e-68

BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor (LRBA) and neurobeachin. Disruption of LYST leads to Chediak-Higashi syndrome, characterized by severe immunodeficiency, albinism, poor blood coagulation and neurologic problems. Neurobeachin is a candidate gene linked to autism. LBRA seems to be upregulated in several cancer types. It has been shown that the BEACH domain itself is important for the function of these proteins.


Pssm-ID: 100117 [Multi-domain]  Cd Length: 275  Bit Score: 219.81  E-value: 9.77e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766  39 IAETWKNCLDGATDFKELIPEFYDeDVSFLVNSLKLDLGKRQGGQmVDDVDLPAWASSPQDFLQKNKDALESGYVSEHLH 118
Cdd:cd06071   132 IPSSWRSASENPSDVKELIPEFYY-LPEFFLNINKFDFGKQDGEK-VNDVELPPWAKSPEEFIRKHREALESEYVSKNLH 209

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907154766 119 EWIDLIFGYKQKGSEAIGAHNVFHPLTYEGGVDLNSIEdpDEKVAMLTQILEFGQTPKQLFVTPHPRR 186
Cdd:cd06071   210 HWIDLIFGYKQRGEEAVKAKNVFHPLTYEGSVDLDSID--VEREAIEAQINNFGQTPVQLFTKPHPKR 275
WD40 COG2319
WD40 repeat [General function prediction only];
230-537 2.20e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 158.92  E-value: 2.20e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 230 NIAKLQLHEQYKIHKEAVTGIAVSCNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDTTVISSSWDNN 309
Cdd:COG2319   106 DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 310 VYFYSIAFGRRQDTLMGHDDAVSKICWHND--RLYSGSWDSTVKVWSgvpaemPGTKRhqfdLLAELEHDVSMtyllekV 387
Cdd:COG2319   186 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDgkLLASGSADGTVRLWD------LATGK----LLRTLTGHSGS------V 249

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 388 NTINLNAVSTLLVSGTKEGMVNIWDLTTATLLHQTSCHSGTVCDAAFSPDSRHILSTGVDGCLNVIDVQTGMLISSM-AS 466
Cdd:COG2319   250 RSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLtGH 329

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907154766 467 EEPQRCFVW--DGNSVLSGSRSGELLVWDLLGAKVSERIQGHTGAVTCMWMNEQCSSIITGGEDRQIMFWKLQ 537
Cdd:COG2319   330 TGAVRSVAFspDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 236-535 2.40e-40

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 147.48  E-value: 2.40e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 236 LHEQYKIHKEAVTGIAVSCNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDTTVISSSWDNNVYFYSI 315
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 316 AFGRRQDTLMGHDDAVSKICWHNDR--LYSGSWDSTVKVWSGVPAEMPGTKRHQFDLlaelehdvsmtyllekVNTINLN 393
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTDW----------------VNSVAFS 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 394 AVSTLLVSGTKEGMVNIWDLTTATLLHQTSCHSGTVCDAAFSPDSRHILSTGVDGCLNVIDVQTGMLISSMASEEPQRCF 473
Cdd:cd00200   145 PDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNS 224

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907154766 474 VW---DGNSVLSGSRSGELLVWDLLGAKVSERIQGHTGAVTCMWMNEQCSSIITGGEDRQIMFWK 535
Cdd:cd00200   225 VAfspDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PTZ00421 PTZ00421
coronin; Provisional
 338-493 1.08e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 51.05  E-value: 1.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 338 NDRLYSGSWDSTVKVWsGVPAEmpGTKRHQFDLLAELE-HDvsmtyllEKVNTINLN-AVSTLLVSGTKEGMVNIWDLTT 415
Cdd:PTZ00421   88 PQKLFTASEDGTIMGW-GIPEE--GLTQNISDPIVHLQgHT-------KKVGIVSFHpSAMNVLASAGADMVVNVWDVER 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 416 ATLLHQTSCHSGTVCDAAFSPDSRHILSTGVDGCLNVIDVQTGMLISSM---ASEEPQRCfVW--DGNSVL----SGSRS 486
Cdd:PTZ00421  158 GKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVeahASAKSQRC-LWakRKDLIItlgcSKSQQ 236


                  ....*..
gi 1907154766 487 GELLVWD 493
Cdd:PTZ00421  237 RQIMLWD 243
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 323-354 7.35e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 7.35e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907154766  323 TLMGHDDAVSKICWHND--RLYSGSWDSTVKVWS 354
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDgkYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
318-354 2.86e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.86e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907154766 318 GRRQDTLMGHDDAVSKICWHNDR--LYSGSWDSTVKVWS 354
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGklLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
Beach pfam02138
Beige/BEACH domain;
39-186 2.76e-84

Beige/BEACH domain;


Pssm-ID: 460459  Cd Length: 277  Bit Score: 262.80  E-value: 2.76e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766  39 IAETWKNCLDGATDFKELIPEFYDeDVSFLVNSLKLDLGKRQGGQMVDDVDLPAWA-SSPQDFLQKNKDALESGYVSEHL 117
Cdd:pfam02138 130 IEEAWRSASNSTSDVKELIPEFFY-LPEFLLNSNNFDLGGRQDGEKVDDVELPPWAkKSPEEFVRKHREALESDYVSENL 208

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907154766 118 HEWIDLIFGYKQKGSEAIGAHNVFHPLTYEGGVDLNSIEDPDEKVAMLTQILEFGQTPKQLFVTPHPRR 186
Cdd:pfam02138 209 HEWIDLIFGYKQRGEEAVEALNVFHPLTYEGSVDLDSIKDPVERDAIEAQIKNFGQTPKQLFTKPHPPR 277
Beach smart01026
Beige/BEACH domain; The BEACH domain was described in the BEIGE protein (D1035670) and in the ...
 39-186 6.13e-84

Beige/BEACH domain; The BEACH domain was described in the BEIGE protein (D1035670) and in the highly homologous CHS protein. The BEACH domain is usually followed by a series of WD repeats. The function of the BEACH domain is unknown.


Pssm-ID: 214982  Cd Length: 280  Bit Score: 262.16  E-value: 6.13e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766   39 IAETWKNC-LDGATDFKELIPEFYDeDVSFLVNSLKLDLGKRQGGQMVDDVDLPAWA-SSPQDFLQKNKDALESGYVSEH 116
Cdd:smart01026 132 VAATWRSAsLESMTDVKELIPEFFY-LPEFLVNINGFDFGTRQDGEDVDDVELPPWAkGSPEEFIRKHREALESEYVSQH 210

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766  117 LHEWIDLIFGYKQKGSEAIGAHNVFHPLTYEGGVDLNSIEDPDEKVAMLTQILEFGQTPKQLFVTPHPRR 186
Cdd:smart01026 211 LHHWIDLIFGYKQRGKEAVEALNVFHPLTYEGAVDLDSIEDPVERKALEGQIHNFGQTPKQLFKEPHPPR 280
Beach cd06071
BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in ...
 39-186 9.77e-68

BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor (LRBA) and neurobeachin. Disruption of LYST leads to Chediak-Higashi syndrome, characterized by severe immunodeficiency, albinism, poor blood coagulation and neurologic problems. Neurobeachin is a candidate gene linked to autism. LBRA seems to be upregulated in several cancer types. It has been shown that the BEACH domain itself is important for the function of these proteins.


Pssm-ID: 100117 [Multi-domain]  Cd Length: 275  Bit Score: 219.81  E-value: 9.77e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766  39 IAETWKNCLDGATDFKELIPEFYDeDVSFLVNSLKLDLGKRQGGQmVDDVDLPAWASSPQDFLQKNKDALESGYVSEHLH 118
Cdd:cd06071   132 IPSSWRSASENPSDVKELIPEFYY-LPEFFLNINKFDFGKQDGEK-VNDVELPPWAKSPEEFIRKHREALESEYVSKNLH 209

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907154766 119 EWIDLIFGYKQKGSEAIGAHNVFHPLTYEGGVDLNSIEdpDEKVAMLTQILEFGQTPKQLFVTPHPRR 186
Cdd:cd06071   210 HWIDLIFGYKQRGEEAVKAKNVFHPLTYEGSVDLDSID--VEREAIEAQINNFGQTPVQLFTKPHPKR 275
WD40 COG2319
WD40 repeat [General function prediction only];
230-537 2.20e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 158.92  E-value: 2.20e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 230 NIAKLQLHEQYKIHKEAVTGIAVSCNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDTTVISSSWDNN 309
Cdd:COG2319   106 DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 310 VYFYSIAFGRRQDTLMGHDDAVSKICWHND--RLYSGSWDSTVKVWSgvpaemPGTKRhqfdLLAELEHDVSMtyllekV 387
Cdd:COG2319   186 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDgkLLASGSADGTVRLWD------LATGK----LLRTLTGHSGS------V 249

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 388 NTINLNAVSTLLVSGTKEGMVNIWDLTTATLLHQTSCHSGTVCDAAFSPDSRHILSTGVDGCLNVIDVQTGMLISSM-AS 466
Cdd:COG2319   250 RSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLtGH 329

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907154766 467 EEPQRCFVW--DGNSVLSGSRSGELLVWDLLGAKVSERIQGHTGAVTCMWMNEQCSSIITGGEDRQIMFWKLQ 537
Cdd:COG2319   330 TGAVRSVAFspDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 236-535 2.40e-40

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 147.48  E-value: 2.40e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 236 LHEQYKIHKEAVTGIAVSCNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDTTVISSSWDNNVYFYSI 315
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 316 AFGRRQDTLMGHDDAVSKICWHNDR--LYSGSWDSTVKVWSGVPAEMPGTKRHQFDLlaelehdvsmtyllekVNTINLN 393
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTDW----------------VNSVAFS 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 394 AVSTLLVSGTKEGMVNIWDLTTATLLHQTSCHSGTVCDAAFSPDSRHILSTGVDGCLNVIDVQTGMLISSMASEEPQRCF 473
Cdd:cd00200   145 PDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNS 224

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907154766 474 VW---DGNSVLSGSRSGELLVWDLLGAKVSERIQGHTGAVTCMWMNEQCSSIITGGEDRQIMFWK 535
Cdd:cd00200   225 VAfspDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
219-537 4.77e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 150.06  E-value: 4.77e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 219 LTEESRTLAWSNIAKLQLHEQYKIHKEAVTGIAVSCNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGD 298
Cdd:COG2319    53 AGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDG 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 299 TTVISSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHND--RLYSGSWDSTVKVWSgvpaempgtkRHQFDLLAELE- 375
Cdd:COG2319   133 KTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDgkLLASGSDDGTVRLWD----------LATGKLLRTLTg 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 376 HDVSmtyllekVNTINLNAVSTLLVSGTKEGMVNIWDLTTATLLHQTSCHSGTVCDAAFSPDSRHILSTGVDGCLNVIDV 455
Cdd:COG2319   203 HTGA-------VRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL 275

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 456 QTGMLISSMASEEPQR---CFVWDGNSVLSGSRSGELLVWDLLGAKVSERIQGHTGAVTCMWMNEQCSSIITGGEDRQIM 532
Cdd:COG2319   276 ATGELLRTLTGHSGGVnsvAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVR 355


                  ....*
gi 1907154766 533 FWKLQ 537
Cdd:COG2319   356 LWDLA 360
WD40 COG2319
WD40 repeat [General function prediction only];
223-537 1.16e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 137.74  E-value: 1.16e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 223 SRTLAWSNIAKLQLHEQYKIHKEAVTGIAVSCNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDTTVI 302
Cdd:COG2319    15 DLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 303 SSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHND--RLYSGSWDSTVKVWSgvpaemPGTKRhqfdLLAELE-HDvs 379
Cdd:COG2319    95 SASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDgkTLASGSADGTVRLWD------LATGK----LLRTLTgHS-- 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 380 mtyllEKVNTINLNAVSTLLVSGTKEGMVNIWDLTTATLLHQTSCHSGTVCDAAFSPDSRHILSTGVDGCLNVIDVQTGM 459
Cdd:COG2319   163 -----GAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 460 LISSMASEEPQ-RCFVW--DGNSVLSGSRSGELLVWDLLGAKVSERIQGHTGAVTCMWMNEQCSSIITGGEDRQIMFWKL 536
Cdd:COG2319   238 LLRTLTGHSGSvRSVAFspDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL 317


                  .
gi 1907154766 537 Q 537
Cdd:COG2319   318 A 318
WD40 COG2319
WD40 repeat [General function prediction only];
228-494 8.24e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.34  E-value: 8.24e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 228 WsNIAKLQLHEQYKIHKEAVTGIAVSCNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDTTVISSSWD 307
Cdd:COG2319   147 W-DLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSAD 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 308 NNVYFYSIAFGRRQDTLMGHDDAVSKICWHND--RLYSGSWDSTVKVWSGVPAEMPGTKRHQFDllaelehdvsmtylle 385
Cdd:COG2319   226 GTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDgrLLASGSADGTVRLWDLATGELLRTLTGHSG---------------- 289

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 386 KVNTINLNAVSTLLVSGTKEGMVNIWDLTTATLLHQTSCHSGTVCDAAFSPDSRHILSTGVDGCLNVIDVQTGML----- 460
Cdd:COG2319   290 GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELlrtlt 369

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1907154766 461 -----ISSMAseepqrcFVWDGNSVLSGSRSGELLVWDL 494
Cdd:COG2319   370 ghtgaVTSVA-------FSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
228-457 1.35e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 120.40  E-value: 1.35e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 228 WsNIAKLQLHEQYKIHKEAVTGIAVSCNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDTTVISSSWD 307
Cdd:COG2319   189 W-DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD 267

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 308 NNVYFYSIAFGRRQDTLMGHDDAVSKICWHND--RLYSGSWDSTVKVWSgvpaemPGTKRhqfdLLAELEHDVSMtylle 385
Cdd:COG2319   268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDgkLLASGSDDGTVRLWD------LATGK----LLRTLTGHTGA----- 332

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907154766 386 kVNTINLNAVSTLLVSGTKEGMVNIWDLTTATLLHQTSCHSGTVCDAAFSPDSRHILSTGVDGCLNVIDVQT 457
Cdd:COG2319   333 -VRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 230-452 6.27e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.20  E-value: 6.27e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 230 NIAKLQLHEQYKIHKEAVTGIAVSCNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDTTVISSSWDNN 309
Cdd:cd00200    79 DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 310 VYFYSIAFGRRQDTLMGHDDAVSKICWHND--RLYSGSWDSTVKVWSgvpaempgtkRHQFDLLAELE-HDVSmtyllek 386
Cdd:cd00200   159 IKLWDLRTGKCVATLTGHTGEVNSVAFSPDgeKLLSSSSDGTIKLWD----------LSTGKCLGTLRgHENG------- 221

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907154766 387 VNTINLNAVSTLLVSGTKEGMVNIWDLTTATLLHQTSCHSGTVCDAAFSPDSRHILSTGVDGCLNV 452
Cdd:cd00200   222 VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 323-537 4.41e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 110.89  E-value: 4.41e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 323 TLMGHDDAVSKICWHND--RLYSGSWDSTVKVWSgvpaempgtkrhqfdllaeLEHDVSMTYL---LEKVNTINLNAVST 397
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDgkLLATGSGDGTIKVWD-------------------LETGELLRTLkghTGPVRDVAASADGT 64

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 398 LLVSGTKEGMVNIWDLTTATLLHQTSCHSGTVCDAAFSPDSRHILSTGVDGCLNVIDVQTGMLISSMAS-EEPQRCFVWD 476
Cdd:cd00200    65 YLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGhTDWVNSVAFS 144

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907154766 477 GNS--VLSGSRSGELLVWDLLGAKVSERIQGHTGAVTCMWMNEQCSSIITGGEDRQIMFWKLQ 537
Cdd:cd00200   145 PDGtfVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS 207
PTZ00421 PTZ00421
coronin; Provisional
 338-493 1.08e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 51.05  E-value: 1.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 338 NDRLYSGSWDSTVKVWsGVPAEmpGTKRHQFDLLAELE-HDvsmtyllEKVNTINLN-AVSTLLVSGTKEGMVNIWDLTT 415
Cdd:PTZ00421   88 PQKLFTASEDGTIMGW-GIPEE--GLTQNISDPIVHLQgHT-------KKVGIVSFHpSAMNVLASAGADMVVNVWDVER 157

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 416 ATLLHQTSCHSGTVCDAAFSPDSRHILSTGVDGCLNVIDVQTGMLISSM---ASEEPQRCfVW--DGNSVL----SGSRS 486
Cdd:PTZ00421  158 GKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVeahASAKSQRC-LWakRKDLIItlgcSKSQQ 236


                  ....*..
gi 1907154766 487 GELLVWD 493
Cdd:PTZ00421  237 RQIMLWD 243
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 323-354 7.35e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 7.35e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907154766  323 TLMGHDDAVSKICWHND--RLYSGSWDSTVKVWS 354
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDgkYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
318-354 2.86e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.86e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907154766 318 GRRQDTLMGHDDAVSKICWHNDR--LYSGSWDSTVKVWS 354
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGklLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 415-454 8.23e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 8.23e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907154766  415 TATLLHQTSCHSGTVCDAAFSPDSRHILSTGVDGCLNVID 454
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 230-314 1.33e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.78  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907154766 230 NIAKLQLHEQYKIHKEAVTGIAVSCNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDTTVISSSWDNN 309
Cdd:cd00200   205 DLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGT 284


                  ....*
gi 1907154766 310 VYFYS 314
Cdd:cd00200   285 IRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
417-454 1.93e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.93e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907154766 417 TLLHQTSCHSGTVCDAAFSPDSRHILSTGVDGCLNVID 454
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 498-535 2.71e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 2.71e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1907154766  498 KVSERIQGHTGAVTCMWMNEQCSSIITGGEDRQIMFWK 535
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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