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Conserved domains on  [gi|1907150462|ref|XP_036018979|]
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rap1 GTPase-GDP dissociation stimulator 1 isoform X2 [Mus musculus]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 10640621)

armadillo/beta-catenin-like repeat-containing protein similar to catenins and plakophilins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 168-211 7.02e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.02  E-value: 7.02e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1907150462  168 NDGNCIHMVDNGIVEKLMDLLDrhveDGNVTVQHAALSALRNLA 211
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLK----SEDEEVVKEAAWALSNLS 40
PLN03200 super family cl33659
cellulose synthase-interactive protein; Provisional
 179-330 8.07e-03

cellulose synthase-interactive protein; Provisional


The actual alignment was detected with superfamily member PLN03200:

Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 38.93  E-value: 8.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150462  179 GIVEKLMDLLDRHVEDGNVtVQHAALSALRNLAipvvNK-----AKMLSAGVTETVLKFLKSEMPPVQFKLLGTLRMLID 253
Cdd:PLN03200   144 GVVPSLWDQLQPGNKQDKV-VEGLLTGALRNLC----GStdgfwSATLEAGGVDILVKLLSSGNSDAQANAASLLARLMM 218

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907150462  254 AQEAAEQLGKNAKLVERLVEWCEAKDHAGVMGESNRLLSALIrhSKSKDVIKTIVQSGGIKHLV--TMATSEHViMQNE 330
Cdd:PLN03200   219 AFESSISKVLDAGAVKQLLKLLGQGNEVSVRAEAAGALEALS--SQSKEAKQAIADAGGIPALInaTVAPSKEF-MQGE 294
 
Name Accession Description Interval E-value
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 168-211 7.02e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.02  E-value: 7.02e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1907150462  168 NDGNCIHMVDNGIVEKLMDLLDrhveDGNVTVQHAALSALRNLA 211
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLK----SEDEEVVKEAAWALSNLS 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 168-211 2.18e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 35.51  E-value: 2.18e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1907150462 168 NDGNCIHMVDNGIVEKLMDLLDrhveDGNVTVQHAALSALRNLA 211
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLS----SPDEEVQEEAAWALSNLA 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 179-330 8.07e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 38.93  E-value: 8.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150462  179 GIVEKLMDLLDRHVEDGNVtVQHAALSALRNLAipvvNK-----AKMLSAGVTETVLKFLKSEMPPVQFKLLGTLRMLID 253
Cdd:PLN03200   144 GVVPSLWDQLQPGNKQDKV-VEGLLTGALRNLC----GStdgfwSATLEAGGVDILVKLLSSGNSDAQANAASLLARLMM 218

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907150462  254 AQEAAEQLGKNAKLVERLVEWCEAKDHAGVMGESNRLLSALIrhSKSKDVIKTIVQSGGIKHLV--TMATSEHViMQNE 330
Cdd:PLN03200   219 AFESSISKVLDAGAVKQLLKLLGQGNEVSVRAEAAGALEALS--SQSKEAKQAIADAGGIPALInaTVAPSKEF-MQGE 294
 
Name Accession Description Interval E-value
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 168-211 7.02e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.02  E-value: 7.02e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1907150462  168 NDGNCIHMVDNGIVEKLMDLLDrhveDGNVTVQHAALSALRNLA 211
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLK----SEDEEVVKEAAWALSNLS 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 168-211 2.18e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 35.51  E-value: 2.18e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1907150462 168 NDGNCIHMVDNGIVEKLMDLLDrhveDGNVTVQHAALSALRNLA 211
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLS----SPDEEVQEEAAWALSNLA 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 179-330 8.07e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 38.93  E-value: 8.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907150462  179 GIVEKLMDLLDRHVEDGNVtVQHAALSALRNLAipvvNK-----AKMLSAGVTETVLKFLKSEMPPVQFKLLGTLRMLID 253
Cdd:PLN03200   144 GVVPSLWDQLQPGNKQDKV-VEGLLTGALRNLC----GStdgfwSATLEAGGVDILVKLLSSGNSDAQANAASLLARLMM 218

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907150462  254 AQEAAEQLGKNAKLVERLVEWCEAKDHAGVMGESNRLLSALIrhSKSKDVIKTIVQSGGIKHLV--TMATSEHViMQNE 330
Cdd:PLN03200   219 AFESSISKVLDAGAVKQLLKLLGQGNEVSVRAEAAGALEALS--SQSKEAKQAIADAGGIPALInaTVAPSKEF-MQGE 294
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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