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Conserved domains on  [gi|1907131791|ref|XP_036017331|]
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glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X2 [Mus musculus]

Protein Classification

glycerol-3-phosphate acyltransferase( domain architecture ID 13250295)

glycerol-3-phosphate acyltransferase catalyzes the incorporation of an acyl group from acylCoA into the acceptor glycerol 3-phosphate

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LPLAT_DHAPAT-like cd07993
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; ...
201-411 7.22e-99

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and similar proteins.


:

Pssm-ID: 153255 [Multi-domain]  Cd Length: 205  Bit Score: 305.65  E-value: 7.22e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 201 FWNIQIHKGQLEMVKAATETNLPLLFLPVHRSHIDYLLLTFILFCHNIKAPYIASGNNLNIPVFSTLIHKLGGFFIRRRL 280
Cdd:cd07993     1 FDGVQVNEGQLERLRKAAQEGHPVVLLPTHRSYLDFLLLSFILFSLGLPLPHIAAGENLNIPILGTLLRRLGAFFIRRSF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 281 DetpdgrKDILYRALLHGHVVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTLSSNTIPDILVIPVGISYDRII 360
Cdd:cd07993    81 G------KDPLYRAVLQEYVQELLKNGQPLEFFIEGTRSRTGKLLPPKLGLLSVVVEAYLKGSVPDVLIVPVSISYDRVL 154
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907131791 361 EGHYNGEQLGKPKKNESLWSVARGVIRMLRKNYGYVRVDFAQPFSLKEYLE 411
Cdd:cd07993   155 EEELYAEELLGPPKPKESLSGLLGASKILRENFGRIRVDFGEPISLREYLG 205
PlsB super family cl30506
Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate ...
129-656 9.57e-82

Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate O-acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


The actual alignment was detected with superfamily member COG2937:

Pssm-ID: 442180 [Multi-domain]  Cd Length: 707  Bit Score: 276.80  E-value: 9.57e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 129 VTENVLSSSRVQEAIAEVAAELNpdgsaqqqsKAIQKVKRKARKILQEMVATVSPGMIRLTGWVLLKLFNSFFWNIQIHk 208
Cdd:COG2937   122 LIERLLRSPAVRKAIEEEAKSKG---------ISEEKARKEARRYLREIAADFSYSAIRFLDRVLRWLWNRLYDGIRVD- 191
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 209 gQLEMVKAATETNlPLLFLPVHRSHIDYLLLTFILFCHNIKAPYIASGNNLNIPVFSTLIHKLGGFFIRRRLdetpdgRK 288
Cdd:COG2937   192 -NLERLRELAKGH-EIVYVPCHRSHMDYLLLSYVLYHNGLVPPHIAAGINLNFWPLGPILRRGGAFFIRRSF------KG 263
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 289 DILYRALLHGHVVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTLSSNTIPDILVIPVGISYDRIIEGH-YNGE 367
Cdd:COG2937   264 NKLYSAVFREYLAELFERGYSVEYFIEGGRSRTGRLLPPKTGMLSMTVQAFLRGARRPVVFVPVYIGYERVLEVGsYAKE 343
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 368 QLGKPKKNESLWSVARGvIRMLRKNYGYVRVDFAQPFSLKEYLegqsqkpvsaplsleqallpailpsrpndvaDEHQ-D 446
Cdd:COG2937   344 LRGGEKKKESLGGLLRA-LRKLRRRFGRVYVNFGEPISLSEYL-------------------------------DQHVpD 391
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 447 LSSNESRNPAdeaFRRRLIANLAEHILFTASKSCAIMSTHIVACLLLYRHRQGI---HLSTLVEDFFVMKEEVLARDFDL 523
Cdd:COG2937   392 WRESEDLRPE---WLRPAVDKLAFEIMVRINRAAAVNPVNLVALALLASPKRALteaELLAQLDLYLDLLRNVPYSLSVT 468
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 524 GFSGNSEDVVMHAIQLlgNCVTITHTSRKDEFFITPSTTVpsvfELNFYSNGVLHVFIMEAIIACsiyAVLNKRCsggsa 603
Cdd:COG2937   469 LPELTPEELLEHLLSL--GLIEVEKDGLGDVISIDDEQAV----LLTYYRNNILHLFALPALIAS---ALLANRR----- 534
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907131791 604 gglgnlISQEQLVRKAASLCYLLSNEGTISLPcQTFYQVCHETVGKFIQYGIL 656
Cdd:COG2937   535 ------ISRAELLELVRLLYPLLKAELFLRWD-AEFEEVLDEELDELVRQGLL 580
 
Name Accession Description Interval E-value
LPLAT_DHAPAT-like cd07993
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; ...
201-411 7.22e-99

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and similar proteins.


Pssm-ID: 153255 [Multi-domain]  Cd Length: 205  Bit Score: 305.65  E-value: 7.22e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 201 FWNIQIHKGQLEMVKAATETNLPLLFLPVHRSHIDYLLLTFILFCHNIKAPYIASGNNLNIPVFSTLIHKLGGFFIRRRL 280
Cdd:cd07993     1 FDGVQVNEGQLERLRKAAQEGHPVVLLPTHRSYLDFLLLSFILFSLGLPLPHIAAGENLNIPILGTLLRRLGAFFIRRSF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 281 DetpdgrKDILYRALLHGHVVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTLSSNTIPDILVIPVGISYDRII 360
Cdd:cd07993    81 G------KDPLYRAVLQEYVQELLKNGQPLEFFIEGTRSRTGKLLPPKLGLLSVVVEAYLKGSVPDVLIVPVSISYDRVL 154
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907131791 361 EGHYNGEQLGKPKKNESLWSVARGVIRMLRKNYGYVRVDFAQPFSLKEYLE 411
Cdd:cd07993   155 EEELYAEELLGPPKPKESLSGLLGASKILRENFGRIRVDFGEPISLREYLG 205
PlsB COG2937
Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate ...
129-656 9.57e-82

Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate O-acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 442180 [Multi-domain]  Cd Length: 707  Bit Score: 276.80  E-value: 9.57e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 129 VTENVLSSSRVQEAIAEVAAELNpdgsaqqqsKAIQKVKRKARKILQEMVATVSPGMIRLTGWVLLKLFNSFFWNIQIHk 208
Cdd:COG2937   122 LIERLLRSPAVRKAIEEEAKSKG---------ISEEKARKEARRYLREIAADFSYSAIRFLDRVLRWLWNRLYDGIRVD- 191
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 209 gQLEMVKAATETNlPLLFLPVHRSHIDYLLLTFILFCHNIKAPYIASGNNLNIPVFSTLIHKLGGFFIRRRLdetpdgRK 288
Cdd:COG2937   192 -NLERLRELAKGH-EIVYVPCHRSHMDYLLLSYVLYHNGLVPPHIAAGINLNFWPLGPILRRGGAFFIRRSF------KG 263
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 289 DILYRALLHGHVVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTLSSNTIPDILVIPVGISYDRIIEGH-YNGE 367
Cdd:COG2937   264 NKLYSAVFREYLAELFERGYSVEYFIEGGRSRTGRLLPPKTGMLSMTVQAFLRGARRPVVFVPVYIGYERVLEVGsYAKE 343
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 368 QLGKPKKNESLWSVARGvIRMLRKNYGYVRVDFAQPFSLKEYLegqsqkpvsaplsleqallpailpsrpndvaDEHQ-D 446
Cdd:COG2937   344 LRGGEKKKESLGGLLRA-LRKLRRRFGRVYVNFGEPISLSEYL-------------------------------DQHVpD 391
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 447 LSSNESRNPAdeaFRRRLIANLAEHILFTASKSCAIMSTHIVACLLLYRHRQGI---HLSTLVEDFFVMKEEVLARDFDL 523
Cdd:COG2937   392 WRESEDLRPE---WLRPAVDKLAFEIMVRINRAAAVNPVNLVALALLASPKRALteaELLAQLDLYLDLLRNVPYSLSVT 468
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 524 GFSGNSEDVVMHAIQLlgNCVTITHTSRKDEFFITPSTTVpsvfELNFYSNGVLHVFIMEAIIACsiyAVLNKRCsggsa 603
Cdd:COG2937   469 LPELTPEELLEHLLSL--GLIEVEKDGLGDVISIDDEQAV----LLTYYRNNILHLFALPALIAS---ALLANRR----- 534
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907131791 604 gglgnlISQEQLVRKAASLCYLLSNEGTISLPcQTFYQVCHETVGKFIQYGIL 656
Cdd:COG2937   535 ------ISRAELLELVRLLYPLLKAELFLRWD-AEFEEVLDEELDELVRQGLL 580
PRK04974 PRK04974
glycerol-3-phosphate 1-O-acyltransferase PlsB;
71-629 3.77e-49

glycerol-3-phosphate 1-O-acyltransferase PlsB;


Pssm-ID: 235325 [Multi-domain]  Cd Length: 818  Bit Score: 186.59  E-value: 3.77e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791  71 TPQSWERFFNPSI----------PSLGLRNVIYINETHTRhrgwLARRLSYIL---FVQERDVHKG--------MFatsv 129
Cdd:PRK04974  150 VPGRLRKLFAILWlgrdtfvrfsPPVSLRYMADEHGTDKR----IARKLARVArvhFRRQRLAAIGpdlphrqaLF---- 221
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 130 tENVLSSSRVQEAIAEVAAELNpdgsaqqqsKAIQKVKRKARKILQEMVATVSPGMIRLTGWVLLKLFNSFFWNIQIHkg 209
Cdd:PRK04974  222 -NKLLASPAIKKAIEDEAKSKK---------ISHEKARQNAIAYMDEIAADYSYSAIRLADRFLTWLWNRLYQGINVH-- 289
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 210 QLEMVKAATETNLPLLFLPVHRSHIDYLLLTFILFCHNIKAPYIASGNNLNIPVFSTLIHKLGGFFIRRrldeTPDGRKd 289
Cdd:PRK04974  290 NAERVRQLAQDGHEIVYVPCHRSHMDYLLLSYVLYHQGLVPPHIAAGINLNFWPAGPIFRRGGAFFIRR----SFKGNK- 364
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 290 iLYRALLHGHVVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDT-LSSNTIPdILVIPVGISYDRIIEGH-YNGE 367
Cdd:PRK04974  365 -LYSTVFREYLGELFARGYSVEYFVEGGRSRTGRLLQPKTGMLAMTLQAmLRGSRRP-ITLVPVYIGYEHVMEVGtYAKE 442
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 368 QLGKPKKNESLWSVARgVIRMLRkNYGYVRVDFAQPFSLKEYLEGQsqkpvsAPLSLEQ-ALLPAILPSRPNDVADehqd 446
Cdd:PRK04974  443 LRGAPKEKESLFQVLR-GIRKLR-NFGQGYVNFGEPIPLNDYLNQH------VPEWRESiDPIEEQRPAWLTPAVN---- 510
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 447 lssnesrnpadeafrrRLIANLAEHIlftaSKSCAIMSTHIVACLLLyRHRQgihlstlvedfFVMKEEVLARDFDLGFS 526
Cdd:PRK04974  511 ----------------NLANQVMVRI----NNAAAANPVNLCALALL-ASRQ-----------RALDREQLIEQLDLYLQ 558
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 527 ---------------GNSEDVVMHAIQLlgNCVTITHTSRKDEFFITPSTTVpsvfELNFYSNGVLHVFIMEAIIACSIY 591
Cdd:PRK04974  559 llrnvpyssdttvpeGSGEELIDHALSL--NKFEVEKDTLGDIISLDREQAV----LMTYYRNNILHLFVLPSLIASIVT 632
                         570       580       590
                  ....*....|....*....|....*....|....*...
gi 1907131791 592 AvlNKRcsggsagglgnlISQEQLVRKAASLCYLLSNE 629
Cdd:PRK04974  633 H--NRR------------ISRDELLRIVNALYPFLKAE 656
PTZ00374 PTZ00374
dihydroxyacetone phosphate acyltransferase; Provisional
80-587 3.17e-47

dihydroxyacetone phosphate acyltransferase; Provisional


Pssm-ID: 240389 [Multi-domain]  Cd Length: 1108  Bit Score: 182.38  E-value: 3.17e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791   80 NPSIPSLGLRNVIYINETHTRHRGWLArrlsyilfvqerDVHKGMFATSVTeNVLSSSRVQEAIAEVAAElnpDGSAQQQ 159
Cdd:PTZ00374   508 TPLLTRKYFDDVVWTQRVGLTANGWRF------------AATPGLTPESLT-SILAQPSIQRLMTALAKK---EGASEKD 571
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791  160 skaiqkVKRKARKILQEMVATVSPGMIRLTGWVLLKLFNSFFWNIQIHKGQLEMVKAATET-NLPLLFLPVHRSHIDYLL 238
Cdd:PTZ00374   572 ------VEARAKAILRTCGDNLNHVQCRLFGLMVRRILFRLYDRVSLNSGAFERLHRYVAMpRVAVVLLPLHRSYIDFII 645
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791  239 LTFILFCHNIKAPYIASGNN-LNIPVFSTLIHKLGGFFIRRRLdetpdgRKDILYRALLHGHVVELLRQQQFLEIFLEGT 317
Cdd:PTZ00374   646 MTYLLAVMGLPLPHVCAGDDfLRMGPIATLMRGSGAFFMRRSF------RDDPLYAALFKEYVRHLVLRRRPLEFFIEGT 719
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791  318 RSRSGKTSCARAGLLSVVVDTL--SSNTIPDILVIPVGISYDRIIEGH-YNGEQLGKPKKNESLWSVARGViRMLRKNYG 394
Cdd:PTZ00374   720 RSRTGKTMAPKLGLLKFICDTFyeGQQELDDVLIIPVSLSYDELLETTlYAKEQLGVSKPKENPGNLLRAR-SLLKRRHG 798
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791  395 YVRVDFAQPFSLKEYLEGQSQKPvsaplsleqallpaiLPSRPND--VADEHQDLSSNESRNPADEAFRRRLIANLAEHI 472
Cdd:PTZ00374   799 KIHVHIGEPVSLRSFKDHPLQCP---------------LPFEPKGeaTTSVCKTLDTTPSIARKSSITPPRVLTNIAWHL 863
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791  473 LFTASKSCAIMSTHIVA-----------CLLLYRHRQGIhlsTLVEDFFVMKEEVLARDfdlGFSGNSEDVVMHAIQLLG 541
Cdd:PTZ00374   864 THKLQRNTIITPTALVAavleclgptagAMPLAEVQQGM---TWLRTNIRRRGAALSDD---CANLNPETMVRKALTHLQ 937
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*.
gi 1907131791  542 NCVTIthTSRKDEFFITPSTTVpSVFELNFYSNGVLHVFIMEAIIA 587
Cdd:PTZ00374   938 EFVEI--TDEMSEVIYVRQDVV-TRLGVNICSNQLIHVFMDEAVVA 980
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
220-355 2.90e-25

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 101.59  E-value: 2.90e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 220 TNLPLLFLPVHRSHIDYLLLTFILFCHNiKAPYIASGNNL-NIPVFSTLIHKLGGFFIRrrldetpdgRKDILYRALLHG 298
Cdd:pfam01553  12 RGGPAIVVANHQSYLDVLLLSLALYKRG-RPLVFVAKKELfDIPLVGWLMRLLGCIFID---------RKNRKDAAGTLE 81
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907131791 299 HVVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTlssntipDILVIPVGIS 355
Cdd:pfam01553  82 YLVELLREGKLVVIFPEGTRSREGELLPFKKGAFRLAIEA-------GVPIVPVAIS 131
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
224-357 3.02e-23

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 95.50  E-value: 3.02e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791  224 LLFLPVHRSHIDYLLLTFILFCHNIKAPYIASGNNLNIPVFSTLIHKLGGFFIRRRLDEtpdgrkdiLYRALLHgHVVEL 303
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGR--------KARAALR-EAVEL 71
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907131791  304 LRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTlssntipDILVIPVGISYD 357
Cdd:smart00563  72 LKEGEWLLIFPEGTRSRPGKLLPFKKGAARLALEA-------GVPIVPVAIRGT 118
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
185-360 7.71e-12

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 65.42  E-value: 7.71e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 185 MIRLTGWVLLKLFNsffWNIQIHkgQLEMVKAATetnlPLLFLPVHRSHIDYLLLTFILfchNIKAPYIASGNNLNIPVF 264
Cdd:COG0204    15 LVRLWARLLLRLLG---VRVRVE--GLENLPADG----PVLIVANHQSWLDILLLLAAL---PRPVRFVAKKELFKIPLL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 265 STLIHKLGGFFIRRRldetpDGRKDIlyRALLHghVVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTlssnti 344
Cdd:COG0204    83 GWLLRALGAIPVDRS-----KRRAAL--RALRQ--AVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEA------ 147
                         170
                  ....*....|....*.
gi 1907131791 345 pDILVIPVGISYDRII 360
Cdd:COG0204   148 -GVPIVPVAIDGTERA 162
GPAT_C pfam19277
Glycerol-3-phosphate acyltransferase C-terminal region; This entry represents the C-terminal ...
364-593 1.72e-11

Glycerol-3-phosphate acyltransferase C-terminal region; This entry represents the C-terminal region of Glycerol-3-phosphate acyltransferase.


Pssm-ID: 466024  Cd Length: 370  Bit Score: 66.77  E-value: 1.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 364 YNGEQLGKPKKNESLWSVARGVIRMLRKNYGYVRVDFAQPFSLKEYLegqsqkpvsaplsleqallpailpsrpndvaDE 443
Cdd:pfam19277   1 YAAELLGGPKKPEGLSWLLSYARSQLSLKLGRVYVRFGEPWSLREFL-------------------------------DE 49
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 444 HQDlssnesRNPADEAFRRRLIANLAEHILFTASKSCAIMSTHIV-ACLLLYRHRqGIHLSTLVEDFFVMKEEVLARDFD 522
Cdd:pfam19277  50 QGD------RPATDAARRRLALQKLAFEVLSRINRVTPVMPTALVgTVLLTLRGR-ALTLSELIRRVEWLLDYIRARGGP 122
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907131791 523 LGFSGN--SEDVVMHAIQLLGNCVTITHTSRKDE--FFITPSttvpSVFELNFYSNGVLHVFIMEAIIACSIYAV 593
Cdd:pfam19277 123 VAHFGDlrTEEVVDRALDVLGNAGLVTRVDGGPEpvYYIAPE----DHFQASFYRNMTIHLFVERAIVELALLTK 193
 
Name Accession Description Interval E-value
LPLAT_DHAPAT-like cd07993
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; ...
201-411 7.22e-99

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and similar proteins.


Pssm-ID: 153255 [Multi-domain]  Cd Length: 205  Bit Score: 305.65  E-value: 7.22e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 201 FWNIQIHKGQLEMVKAATETNLPLLFLPVHRSHIDYLLLTFILFCHNIKAPYIASGNNLNIPVFSTLIHKLGGFFIRRRL 280
Cdd:cd07993     1 FDGVQVNEGQLERLRKAAQEGHPVVLLPTHRSYLDFLLLSFILFSLGLPLPHIAAGENLNIPILGTLLRRLGAFFIRRSF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 281 DetpdgrKDILYRALLHGHVVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTLSSNTIPDILVIPVGISYDRII 360
Cdd:cd07993    81 G------KDPLYRAVLQEYVQELLKNGQPLEFFIEGTRSRTGKLLPPKLGLLSVVVEAYLKGSVPDVLIVPVSISYDRVL 154
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907131791 361 EGHYNGEQLGKPKKNESLWSVARGVIRMLRKNYGYVRVDFAQPFSLKEYLE 411
Cdd:cd07993   155 EEELYAEELLGPPKPKESLSGLLGASKILRENFGRIRVDFGEPISLREYLG 205
PlsB COG2937
Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate ...
129-656 9.57e-82

Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]; Glycerol-3-phosphate O-acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 442180 [Multi-domain]  Cd Length: 707  Bit Score: 276.80  E-value: 9.57e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 129 VTENVLSSSRVQEAIAEVAAELNpdgsaqqqsKAIQKVKRKARKILQEMVATVSPGMIRLTGWVLLKLFNSFFWNIQIHk 208
Cdd:COG2937   122 LIERLLRSPAVRKAIEEEAKSKG---------ISEEKARKEARRYLREIAADFSYSAIRFLDRVLRWLWNRLYDGIRVD- 191
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 209 gQLEMVKAATETNlPLLFLPVHRSHIDYLLLTFILFCHNIKAPYIASGNNLNIPVFSTLIHKLGGFFIRRRLdetpdgRK 288
Cdd:COG2937   192 -NLERLRELAKGH-EIVYVPCHRSHMDYLLLSYVLYHNGLVPPHIAAGINLNFWPLGPILRRGGAFFIRRSF------KG 263
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 289 DILYRALLHGHVVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTLSSNTIPDILVIPVGISYDRIIEGH-YNGE 367
Cdd:COG2937   264 NKLYSAVFREYLAELFERGYSVEYFIEGGRSRTGRLLPPKTGMLSMTVQAFLRGARRPVVFVPVYIGYERVLEVGsYAKE 343
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 368 QLGKPKKNESLWSVARGvIRMLRKNYGYVRVDFAQPFSLKEYLegqsqkpvsaplsleqallpailpsrpndvaDEHQ-D 446
Cdd:COG2937   344 LRGGEKKKESLGGLLRA-LRKLRRRFGRVYVNFGEPISLSEYL-------------------------------DQHVpD 391
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 447 LSSNESRNPAdeaFRRRLIANLAEHILFTASKSCAIMSTHIVACLLLYRHRQGI---HLSTLVEDFFVMKEEVLARDFDL 523
Cdd:COG2937   392 WRESEDLRPE---WLRPAVDKLAFEIMVRINRAAAVNPVNLVALALLASPKRALteaELLAQLDLYLDLLRNVPYSLSVT 468
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 524 GFSGNSEDVVMHAIQLlgNCVTITHTSRKDEFFITPSTTVpsvfELNFYSNGVLHVFIMEAIIACsiyAVLNKRCsggsa 603
Cdd:COG2937   469 LPELTPEELLEHLLSL--GLIEVEKDGLGDVISIDDEQAV----LLTYYRNNILHLFALPALIAS---ALLANRR----- 534
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907131791 604 gglgnlISQEQLVRKAASLCYLLSNEGTISLPcQTFYQVCHETVGKFIQYGIL 656
Cdd:COG2937   535 ------ISRAELLELVRLLYPLLKAELFLRWD-AEFEEVLDEELDELVRQGLL 580
PRK04974 PRK04974
glycerol-3-phosphate 1-O-acyltransferase PlsB;
71-629 3.77e-49

glycerol-3-phosphate 1-O-acyltransferase PlsB;


Pssm-ID: 235325 [Multi-domain]  Cd Length: 818  Bit Score: 186.59  E-value: 3.77e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791  71 TPQSWERFFNPSI----------PSLGLRNVIYINETHTRhrgwLARRLSYIL---FVQERDVHKG--------MFatsv 129
Cdd:PRK04974  150 VPGRLRKLFAILWlgrdtfvrfsPPVSLRYMADEHGTDKR----IARKLARVArvhFRRQRLAAIGpdlphrqaLF---- 221
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 130 tENVLSSSRVQEAIAEVAAELNpdgsaqqqsKAIQKVKRKARKILQEMVATVSPGMIRLTGWVLLKLFNSFFWNIQIHkg 209
Cdd:PRK04974  222 -NKLLASPAIKKAIEDEAKSKK---------ISHEKARQNAIAYMDEIAADYSYSAIRLADRFLTWLWNRLYQGINVH-- 289
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 210 QLEMVKAATETNLPLLFLPVHRSHIDYLLLTFILFCHNIKAPYIASGNNLNIPVFSTLIHKLGGFFIRRrldeTPDGRKd 289
Cdd:PRK04974  290 NAERVRQLAQDGHEIVYVPCHRSHMDYLLLSYVLYHQGLVPPHIAAGINLNFWPAGPIFRRGGAFFIRR----SFKGNK- 364
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 290 iLYRALLHGHVVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDT-LSSNTIPdILVIPVGISYDRIIEGH-YNGE 367
Cdd:PRK04974  365 -LYSTVFREYLGELFARGYSVEYFVEGGRSRTGRLLQPKTGMLAMTLQAmLRGSRRP-ITLVPVYIGYEHVMEVGtYAKE 442
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 368 QLGKPKKNESLWSVARgVIRMLRkNYGYVRVDFAQPFSLKEYLEGQsqkpvsAPLSLEQ-ALLPAILPSRPNDVADehqd 446
Cdd:PRK04974  443 LRGAPKEKESLFQVLR-GIRKLR-NFGQGYVNFGEPIPLNDYLNQH------VPEWRESiDPIEEQRPAWLTPAVN---- 510
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 447 lssnesrnpadeafrrRLIANLAEHIlftaSKSCAIMSTHIVACLLLyRHRQgihlstlvedfFVMKEEVLARDFDLGFS 526
Cdd:PRK04974  511 ----------------NLANQVMVRI----NNAAAANPVNLCALALL-ASRQ-----------RALDREQLIEQLDLYLQ 558
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 527 ---------------GNSEDVVMHAIQLlgNCVTITHTSRKDEFFITPSTTVpsvfELNFYSNGVLHVFIMEAIIACSIY 591
Cdd:PRK04974  559 llrnvpyssdttvpeGSGEELIDHALSL--NKFEVEKDTLGDIISLDREQAV----LMTYYRNNILHLFVLPSLIASIVT 632
                         570       580       590
                  ....*....|....*....|....*....|....*...
gi 1907131791 592 AvlNKRcsggsagglgnlISQEQLVRKAASLCYLLSNE 629
Cdd:PRK04974  633 H--NRR------------ISRDELLRIVNALYPFLKAE 656
PTZ00374 PTZ00374
dihydroxyacetone phosphate acyltransferase; Provisional
80-587 3.17e-47

dihydroxyacetone phosphate acyltransferase; Provisional


Pssm-ID: 240389 [Multi-domain]  Cd Length: 1108  Bit Score: 182.38  E-value: 3.17e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791   80 NPSIPSLGLRNVIYINETHTRHRGWLArrlsyilfvqerDVHKGMFATSVTeNVLSSSRVQEAIAEVAAElnpDGSAQQQ 159
Cdd:PTZ00374   508 TPLLTRKYFDDVVWTQRVGLTANGWRF------------AATPGLTPESLT-SILAQPSIQRLMTALAKK---EGASEKD 571
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791  160 skaiqkVKRKARKILQEMVATVSPGMIRLTGWVLLKLFNSFFWNIQIHKGQLEMVKAATET-NLPLLFLPVHRSHIDYLL 238
Cdd:PTZ00374   572 ------VEARAKAILRTCGDNLNHVQCRLFGLMVRRILFRLYDRVSLNSGAFERLHRYVAMpRVAVVLLPLHRSYIDFII 645
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791  239 LTFILFCHNIKAPYIASGNN-LNIPVFSTLIHKLGGFFIRRRLdetpdgRKDILYRALLHGHVVELLRQQQFLEIFLEGT 317
Cdd:PTZ00374   646 MTYLLAVMGLPLPHVCAGDDfLRMGPIATLMRGSGAFFMRRSF------RDDPLYAALFKEYVRHLVLRRRPLEFFIEGT 719
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791  318 RSRSGKTSCARAGLLSVVVDTL--SSNTIPDILVIPVGISYDRIIEGH-YNGEQLGKPKKNESLWSVARGViRMLRKNYG 394
Cdd:PTZ00374   720 RSRTGKTMAPKLGLLKFICDTFyeGQQELDDVLIIPVSLSYDELLETTlYAKEQLGVSKPKENPGNLLRAR-SLLKRRHG 798
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791  395 YVRVDFAQPFSLKEYLEGQSQKPvsaplsleqallpaiLPSRPND--VADEHQDLSSNESRNPADEAFRRRLIANLAEHI 472
Cdd:PTZ00374   799 KIHVHIGEPVSLRSFKDHPLQCP---------------LPFEPKGeaTTSVCKTLDTTPSIARKSSITPPRVLTNIAWHL 863
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791  473 LFTASKSCAIMSTHIVA-----------CLLLYRHRQGIhlsTLVEDFFVMKEEVLARDfdlGFSGNSEDVVMHAIQLLG 541
Cdd:PTZ00374   864 THKLQRNTIITPTALVAavleclgptagAMPLAEVQQGM---TWLRTNIRRRGAALSDD---CANLNPETMVRKALTHLQ 937
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*.
gi 1907131791  542 NCVTIthTSRKDEFFITPSTTVpSVFELNFYSNGVLHVFIMEAIIA 587
Cdd:PTZ00374   938 EFVEI--TDEMSEVIYVRQDVV-TRLGVNICSNQLIHVFMDEAVVA 980
PRK03355 PRK03355
glycerol-3-phosphate 1-O-acyltransferase;
129-593 7.34e-40

glycerol-3-phosphate 1-O-acyltransferase;


Pssm-ID: 179567 [Multi-domain]  Cd Length: 783  Bit Score: 158.34  E-value: 7.34e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 129 VTENVLSSSRVQEAIAEVAAELNPDGSAqqqskaiqkVKRKARKILQEMVATVSPGMIRLTGwVLLKLFNS-FFWNIQIH 207
Cdd:PRK03355  184 VKPEILASARFRAGLAKIAAKLGRPPGA---------TVREAGKMLDELVAGWSRVSVDLVS-VLGRLFSRgFDPEIDYD 253
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 208 KGQLEMVKAATEtNLPLLFLPVHRSHIDYLLLTFILFCHNIKAPYIASGNNLNIPVFSTLIHKLGGFFIRRRLDETPdgr 287
Cdd:PRK03355  254 EYELAALRALLE-EHPAVLLFSHRSYIDGLVVPVAMQENRLPPVHVFGGINLSFGPMGPIMRRSGMIFIRRNIGDDP--- 329
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 288 kdiLYRALLHGHVVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTLSSNTIPDILVIPVGISYDRIIE-GHYNG 366
Cdd:PRK03355  330 ---LYKYVLREYVGYLVEKRFNLSWYIEGTRSRTGKLLPPKLGLLSYVADAYLDGRSDDVLLQPVSISFDQLHEiGEYAA 406
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 367 EQLGKPKKNESL-WSVarGVIRML-RKNYGYVRVDFAQPFSLKEYLeGQSQKPVSAPLSLEQALLPAIlpsrpndvadeh 444
Cdd:PRK03355  407 EARGGEKTPEGLrWLY--NYIKAQgERNYGKIYVRFGEPVSMRQYL-GAPHGPLTQDPDAKRLALQKM------------ 471
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 445 qdlssnesrnpadeAFRRRLIANLAEHILFTASKSCAIMST-----------HIVACLLLYRHRQGIHLSTlvedffvmk 513
Cdd:PRK03355  472 --------------AFEVAWRINQVTPVTATSLVSLLLLGTrgraltldelhHTLQDSLDYLERRQLPVST--------- 528
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 514 eevlaRDFDLGfsgnSEDVVMHAIQLL--GNCVTITHTSRKDEFFITPSTTVpsvfELNFYSNGVLHVFIMEAIIACSIY 591
Cdd:PRK03355  529 -----SALRLR----DPEGVRAALDALsnGGPVTRVDSGREPVWYIAPDDHL----VAAFYRNSVIHAFLERAIVELALA 595

                  ..
gi 1907131791 592 AV 593
Cdd:PRK03355  596 AA 597
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
220-355 2.90e-25

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 101.59  E-value: 2.90e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 220 TNLPLLFLPVHRSHIDYLLLTFILFCHNiKAPYIASGNNL-NIPVFSTLIHKLGGFFIRrrldetpdgRKDILYRALLHG 298
Cdd:pfam01553  12 RGGPAIVVANHQSYLDVLLLSLALYKRG-RPLVFVAKKELfDIPLVGWLMRLLGCIFID---------RKNRKDAAGTLE 81
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907131791 299 HVVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTlssntipDILVIPVGIS 355
Cdd:pfam01553  82 YLVELLREGKLVVIFPEGTRSREGELLPFKKGAFRLAIEA-------GVPIVPVAIS 131
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
224-357 3.02e-23

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 95.50  E-value: 3.02e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791  224 LLFLPVHRSHIDYLLLTFILFCHNIKAPYIASGNNLNIPVFSTLIHKLGGFFIRRRLDEtpdgrkdiLYRALLHgHVVEL 303
Cdd:smart00563   1 ALVVANHQSFLDPLVLSALLPRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSNGR--------KARAALR-EAVEL 71
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1907131791  304 LRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTlssntipDILVIPVGISYD 357
Cdd:smart00563  72 LKEGEWLLIFPEGTRSRPGKLLPFKKGAARLALEA-------GVPIVPVAIRGT 118
PRK11915 PRK11915
lysophospholipid acyltransferase;
133-429 1.64e-19

lysophospholipid acyltransferase;


Pssm-ID: 237022 [Multi-domain]  Cd Length: 621  Bit Score: 93.47  E-value: 1.64e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 133 VLSSSRVQEAIAEVAAEL--NPDGsaqqqskaiqkVKRKARKILQEMVATVSPGMIRltGWvllKLFNSFF---WNIQIH 207
Cdd:PRK11915   38 LLDARWYDERLRALADELgrDPDS-----------VRAEAAGYLREMAASLDERAVQ--AW---RGFSRWLmraYDVLVD 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 208 KGQLEMVKAaTETNLPLLFLPVHRSHIDYLLLTFILFCHNIKAPYIASGNNLNIPVFSTLIHKLGGFFIRRRLDETPdgr 287
Cdd:PRK11915  102 EDQITQLRK-LDRKATLAFAFSHRSYLDGMLLPEVILANRLSPALTFGGANLNFFPMGAWAKRTGAIFIRRQTKDIP--- 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 288 kdiLYRALLHGHVVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTLSSNTIPDILVIPVGISYDRIIE-GHYNG 366
Cdd:PRK11915  178 ---VYRFVLRAYAAQLVQNHVNLTWSIEGGRTRTGKLRPPVFGILRYITDAVDEIDGPEVYLVPTSIVYDQLHEvEAMTT 254
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907131791 367 EQLGKPKKNESLwsvaRGVIRMLRKN---YGYVRVDFAQPFSLKEYLEGQSQKPVSAPLSLEQALL 429
Cdd:PRK11915  255 EAYGAVKRPEDL----RFLVRLARQQgerLGRAYLDFGEPLPLRKRLQELRADKSGTGSEIERIAL 316
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
185-360 7.71e-12

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 65.42  E-value: 7.71e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 185 MIRLTGWVLLKLFNsffWNIQIHkgQLEMVKAATetnlPLLFLPVHRSHIDYLLLTFILfchNIKAPYIASGNNLNIPVF 264
Cdd:COG0204    15 LVRLWARLLLRLLG---VRVRVE--GLENLPADG----PVLIVANHQSWLDILLLLAAL---PRPVRFVAKKELFKIPLL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 265 STLIHKLGGFFIRRRldetpDGRKDIlyRALLHghVVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTlssnti 344
Cdd:COG0204    83 GWLLRALGAIPVDRS-----KRRAAL--RALRQ--AVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEA------ 147
                         170
                  ....*....|....*.
gi 1907131791 345 pDILVIPVGISYDRII 360
Cdd:COG0204   148 -GVPIVPVAIDGTERA 162
GPAT_C pfam19277
Glycerol-3-phosphate acyltransferase C-terminal region; This entry represents the C-terminal ...
364-593 1.72e-11

Glycerol-3-phosphate acyltransferase C-terminal region; This entry represents the C-terminal region of Glycerol-3-phosphate acyltransferase.


Pssm-ID: 466024  Cd Length: 370  Bit Score: 66.77  E-value: 1.72e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 364 YNGEQLGKPKKNESLWSVARGVIRMLRKNYGYVRVDFAQPFSLKEYLegqsqkpvsaplsleqallpailpsrpndvaDE 443
Cdd:pfam19277   1 YAAELLGGPKKPEGLSWLLSYARSQLSLKLGRVYVRFGEPWSLREFL-------------------------------DE 49
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 444 HQDlssnesRNPADEAFRRRLIANLAEHILFTASKSCAIMSTHIV-ACLLLYRHRqGIHLSTLVEDFFVMKEEVLARDFD 522
Cdd:pfam19277  50 QGD------RPATDAARRRLALQKLAFEVLSRINRVTPVMPTALVgTVLLTLRGR-ALTLSELIRRVEWLLDYIRARGGP 122
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907131791 523 LGFSGN--SEDVVMHAIQLLGNCVTITHTSRKDE--FFITPSttvpSVFELNFYSNGVLHVFIMEAIIACSIYAV 593
Cdd:pfam19277 123 VAHFGDlrTEEVVDRALDVLGNAGLVTRVDGGPEpvYYIAPE----DHFQASFYRNMTIHLFVERAIVELALLTK 193
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
196-356 6.18e-10

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 59.21  E-value: 6.18e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 196 LFNSFFWNIQIHKgqLEMVKAATetnlPLLFLPVHRSHIDYLLLTFILFcHNIKapYIASGNNLNIPVFSTLIHKLGGFF 275
Cdd:cd07989     4 LLRLLGVRVRVEG--LENLPPKG----PVIIVANHQSYLDPLVLGAALP-RPIR--FVAKKELFKIPFLGWLLRLLGAIP 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 276 IRRRldetpDGRKDIlyRALLhgHVVELLRQQQFLEIFLEGTRSRSGKTSCARAGLLSVVVDTlssntipDILVIPVGIS 355
Cdd:cd07989    75 IDRG-----NGRSAR--EALR--EAIEALKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEA-------GVPIVPVAIS 138

                  .
gi 1907131791 356 Y 356
Cdd:cd07989   139 G 139
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
186-358 4.24e-06

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 48.41  E-value: 4.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 186 IRLTGWVLLKLFnsfFWNIQIHKGQLEmvkaatETNLPLLFLPVHR-SHIDYLLLTFILfchNIKAPYIASGNNLNIPVF 264
Cdd:cd07992     1 VRLLSRVILRIY---FRRITVVGRENV------PKDGPVIFLGNHPnALIDPLLLAATL---RRPVRFLAKADLFKNPLI 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 265 STLIHKLGGFFIRRRLDETPDGRKDILYRALLHGhVVELLRQQQFLEIFLEGTrSRSG------KTSCARAGLlsvvvdT 338
Cdd:cd07992    69 GWLLESFGAIPVYRPKDLARGGIGKISNAAVFDA-VGEALKAGGAIGIFPEGG-SHDRprllplKAGAARMAL------E 140
                         170       180
                  ....*....|....*....|
gi 1907131791 339 LSSNTIPDILVIPVGISYDR 358
Cdd:cd07992   141 ALEAGQKDVKIVPVGLNYED 160
LPLAT cd06551
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ...
223-359 1.65e-05

Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).


Pssm-ID: 153244 [Multi-domain]  Cd Length: 187  Bit Score: 46.25  E-value: 1.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907131791 223 PLLFLPVHRSHIDYLLLTFILFC---HNIKAPYIASGnNLNIPVFStlihKLGGFFIRRRLDEtpDGRKDILYrallhgh 299
Cdd:cd06551    27 PVLFVSNHSSWWDGLILFLLLERglrRDVYGLMDEEL-LERYPFFT----RLGAFSVDRDSPR--SAAKSLKY------- 92
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907131791 300 VVELLRQ-QQFLEIFLEGTRSRSGKtscaRAGLLSVVVDTLSsnTIPDILVIPVGISYDRI 359
Cdd:cd06551    93 VARLLSKpGSVVWIFPEGTRTRRDK----RPLQFKPGVAHLA--EKAGVPIVPVALRYTFE 147
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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