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Conserved domains on  [gi|1907100841|ref|XP_036014467|]
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protocadherin-20 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 541-636 4.01e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 114.72  E-value: 4.01e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841 541 IELTIEENNAPNAFLTKLYATDADSGEMGRVSYFL-GPDAPSYFSLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGTPP 619
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*..
gi 1907100841 620 RESVATVALTVLDKNDN 636
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 645-739 7.98e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.78  E-value: 7.98e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841 645 FSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVM--NQSDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPA 722
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*..
gi 1907100841 723 LSSTTKITILLLDINDN 739
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 214-317 1.03e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 96.23  E-value: 1.03e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841 214 EISVWVPENSPVNTRLAIEHpAVDPDVGINGVQTYRLL--DYHGMFTLDveenengERTPYLIVMGALDRETQDQYVSII 291
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVS-ATDPDSGENGEVTYSIVsgNEDGLFSID-------PSTGEITTAKPLDREEQSSYTLTV 72

                          90       100
                  ....*....|....*....|....*.
gi 1907100841 292 IAEDGGSPPLLGSATLTIGISDINDN 317
Cdd:cd11304    73 TATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 755-846 1.10e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.98  E-value: 1.10e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841 755 VLPSTLPGSPVTEVYAVDKDTGMNAVIAYSIIGrrGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPePL 834
Cdd:cd11304     6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVS--GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP-PL 82

                          90
                  ....*....|..
gi 1907100841 835 HSTVMVNLFVND 846
Cdd:cd11304    83 SSTATVTITVLD 94
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 325-417 7.54e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 7.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841 325 QINVTVYGNATVGTPVATVQAVDRDLGTNAQITYSYsqkVPQETKDLFHLDEVTGVIKLSSKIGGSVLQTHKLTILANGP 404
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI---VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90
                  ....*....|...
gi 1907100841 405 GCIPAVITALVSI 417
Cdd:cd11304    78 GGPPLSSTATVTI 90
Cadherin_2 super family cl29227
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 70-153 1.24e-04

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


The actual alignment was detected with superfamily member pfam08266:

Pssm-ID: 462413  Cd Length: 83  Bit Score: 41.36  E-value: 1.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841  70 YSLNEGLPAGVLIGSLAEDLRLLPRA-SGRqnqqllhpertasegnpplSFSLASGGlSGQYVTLNNRSGELHTSaQEID 148
Cdd:pfam08266   4 YSVPEETERGSFVGNLAKDLGLEVGElAAR-------------------GARVVSKG-NKQYFQLNPETGDLLLN-EKLD 62


                  ....*
gi 1907100841 149 REALC 153
Cdd:pfam08266  63 REELC 67
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 490-534 1.03e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member smart00112:

Pssm-ID: 481204 [Multi-domain]  Cd Length: 81  Bit Score: 38.87  E-value: 1.03e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1907100841  490 LETTKPMDYEVQSFYEIAVVA--WNSEGFHVKRIIKVQLLDDNDNAP 534
Cdd:smart00112  35 ITTTKPLDREEQPEYTLTVEAtdGGGPPLSSTATVTITVLDVNDNAP 81
CA_like super family cl46864
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 439-510 1.70e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


The actual alignment was detected with superfamily member pfam00028:

Pssm-ID: 481204 [Multi-domain]  Cd Length: 92  Bit Score: 38.44  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841 439 VVYLKELEPVNTPIAFFTIRDPEG------KYKIncfLDGE--GPFRLAPYKPynneyLLETTKPMDYEVQSFYEIAVVA 510
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLgpngriFYSI---LGGGpgGNFRIDPDTG-----DISTTKPLDRESIGEYELTVEA 73
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 541-636 4.01e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 114.72  E-value: 4.01e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841 541 IELTIEENNAPNAFLTKLYATDADSGEMGRVSYFL-GPDAPSYFSLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGTPP 619
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*..
gi 1907100841 620 RESVATVALTVLDKNDN 636
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 645-739 7.98e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.78  E-value: 7.98e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841 645 FSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVM--NQSDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPA 722
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*..
gi 1907100841 723 LSSTTKITILLLDINDN 739
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 560-638 2.16e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 97.42  E-value: 2.16e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841  560 ATDADSGEMGRVSYFL-GPDAPSYFSLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGTPPRESVATVALTVLDKNDNSP 638
Cdd:smart00112   2 ATDADSGENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 214-317 1.03e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 96.23  E-value: 1.03e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841 214 EISVWVPENSPVNTRLAIEHpAVDPDVGINGVQTYRLL--DYHGMFTLDveenengERTPYLIVMGALDRETQDQYVSII 291
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVS-ATDPDSGENGEVTYSIVsgNEDGLFSID-------PSTGEITTAKPLDREEQSSYTLTV 72

                          90       100
                  ....*....|....*....|....*.
gi 1907100841 292 IAEDGGSPPLLGSATLTIGISDINDN 317
Cdd:cd11304    73 TATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 663-741 1.62e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.11  E-value: 1.62e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841  663 SVTDADAGRNGWVALSVM--NQSDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPALSSTTKITILLLDINDNP 740
Cdd:smart00112   1 SATDADSGENGKVTYSILsgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 1907100841  741 P 741
Cdd:smart00112  81 P 81
Cadherin pfam00028
Cadherin domain;
544-631 1.10e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 84.66  E-value: 1.10e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841 544 TIEENNAPNAFLTKLYATDADSGEMGRVSYF-LGPDAPSYFSLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGTPPRES 622
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSS 83


                  ....*....
gi 1907100841 623 VATVALTVL 631
Cdd:pfam00028  84 TATVTITVL 92
Cadherin pfam00028
Cadherin domain;
645-734 4.13e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.73  E-value: 4.13e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841 645 FSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVMNQ--SDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPA 722
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgpGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                          90
                  ....*....|..
gi 1907100841 723 LSSTTKITILLL 734
Cdd:pfam00028  81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 755-846 1.10e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.98  E-value: 1.10e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841 755 VLPSTLPGSPVTEVYAVDKDTGMNAVIAYSIIGrrGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPePL 834
Cdd:cd11304     6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVS--GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP-PL 82

                          90
                  ....*....|..
gi 1907100841 835 HSTVMVNLFVND 846
Cdd:cd11304    83 SSTATVTITVLD 94
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 235-319 1.05e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.55  E-value: 1.05e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841  235 AVDPDVGINGVQTYRLLD--YHGMFTLDveenengERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSATLTIGIS 312
Cdd:smart00112   2 ATDADSGENGKVTYSILSgnDDGLFSID-------PETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*..
gi 1907100841  313 DINDNCP 319
Cdd:smart00112  75 DVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 325-417 7.54e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 7.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841 325 QINVTVYGNATVGTPVATVQAVDRDLGTNAQITYSYsqkVPQETKDLFHLDEVTGVIKLSSKIGGSVLQTHKLTILANGP 404
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI---VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90
                  ....*....|...
gi 1907100841 405 GCIPAVITALVSI 417
Cdd:cd11304    78 GGPPLSSTATVTI 90
Cadherin pfam00028
Cadherin domain;
219-309 4.76e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.48  E-value: 4.76e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841 219 VPENSPVNTRLAIEHpAVDPDVGINGVQTYRLL--DYHGMFTLDveenengERTPYLIVMGALDRETQDQYVSIIIAEDG 296
Cdd:pfam00028   5 VPENAPVGTEVLTVT-ATDPDLGPNGRIFYSILggGPGGNFRID-------PDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|...
gi 1907100841 297 GSPPLLGSATLTI 309
Cdd:pfam00028  77 GGPPLSSTATVTI 89
Cadherin pfam00028
Cadherin domain;
761-844 1.69e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.94  E-value: 1.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841 761 PGSPVTEVYAVDKDTGMNAVIAYSIIGrrGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPePLHSTVMV 840
Cdd:pfam00028  11 VGTEVLTVTATDPDLGPNGRIFYSILG--GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP-PLSSTATV 87


                  ....
gi 1907100841 841 NLFV 844
Cdd:pfam00028  88 TITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 770-846 7.10e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.68  E-value: 7.10e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907100841  770 AVDKDTGMNAVIAYSIIGrrGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPePLHSTVMVNLFVND 846
Cdd:smart00112   2 ATDADSGENGKVTYSILS--GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVLD 75
Cadherin pfam00028
Cadherin domain;
326-417 5.56e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.93  E-value: 5.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841 326 INVTVYGNATVGTPVATVQAVDRDLGTNAQITYSysqKVPQETKDLFHLDEVTGVIKLSSKIGGSVLQTHKLTILANGPG 405
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYS---ILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|..
gi 1907100841 406 CIPAVITALVSI 417
Cdd:pfam00028  78 GPPLSSTATVTI 89
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 344-418 1.30e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 46.96  E-value: 1.30e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907100841  344 QAVDRDLGTNAQITYSysqKVPQETKDLFHLDEVTGVIKLSSKIGGSVLQTHKLTILANGPGCIPAVITALVSII 418
Cdd:smart00112   1 SATDADSGENGKVTYS---ILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 70-153 1.24e-04

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 41.36  E-value: 1.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841  70 YSLNEGLPAGVLIGSLAEDLRLLPRA-SGRqnqqllhpertasegnpplSFSLASGGlSGQYVTLNNRSGELHTSaQEID 148
Cdd:pfam08266   4 YSVPEETERGSFVGNLAKDLGLEVGElAAR-------------------GARVVSKG-NKQYFQLNPETGDLLLN-EKLD 62


                  ....*
gi 1907100841 149 REALC 153
Cdd:pfam08266  63 REELC 67
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 490-534 1.03e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.87  E-value: 1.03e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1907100841  490 LETTKPMDYEVQSFYEIAVVA--WNSEGFHVKRIIKVQLLDDNDNAP 534
Cdd:smart00112  35 ITTTKPLDREEQPEYTLTVEAtdGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
439-510 1.70e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 38.44  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841 439 VVYLKELEPVNTPIAFFTIRDPEG------KYKIncfLDGE--GPFRLAPYKPynneyLLETTKPMDYEVQSFYEIAVVA 510
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLgpngriFYSI---LGGGpgGNFRIDPDTG-----DISTTKPLDRESIGEYELTVEA 73
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 541-636 4.01e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 114.72  E-value: 4.01e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841 541 IELTIEENNAPNAFLTKLYATDADSGEMGRVSYFL-GPDAPSYFSLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGTPP 619
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIvSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*..
gi 1907100841 620 RESVATVALTVLDKNDN 636
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 645-739 7.98e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.78  E-value: 7.98e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841 645 FSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVM--NQSDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPA 722
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                          90
                  ....*....|....*..
gi 1907100841 723 LSSTTKITILLLDINDN 739
Cdd:cd11304    82 LSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 560-638 2.16e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 97.42  E-value: 2.16e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841  560 ATDADSGEMGRVSYFL-GPDAPSYFSLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGTPPRESVATVALTVLDKNDNSP 638
Cdd:smart00112   2 ATDADSGENGKVTYSIlSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 214-317 1.03e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 96.23  E-value: 1.03e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841 214 EISVWVPENSPVNTRLAIEHpAVDPDVGINGVQTYRLL--DYHGMFTLDveenengERTPYLIVMGALDRETQDQYVSII 291
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVS-ATDPDSGENGEVTYSIVsgNEDGLFSID-------PSTGEITTAKPLDREEQSSYTLTV 72

                          90       100
                  ....*....|....*....|....*.
gi 1907100841 292 IAEDGGSPPLLGSATLTIGISDINDN 317
Cdd:cd11304    73 TATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 663-741 1.62e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.11  E-value: 1.62e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841  663 SVTDADAGRNGWVALSVM--NQSDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPALSSTTKITILLLDINDNP 740
Cdd:smart00112   1 SATDADSGENGKVTYSILsgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                   .
gi 1907100841  741 P 741
Cdd:smart00112  81 P 81
Cadherin pfam00028
Cadherin domain;
544-631 1.10e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 84.66  E-value: 1.10e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841 544 TIEENNAPNAFLTKLYATDADSGEMGRVSYF-LGPDAPSYFSLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGTPPRES 622
Cdd:pfam00028   4 SVPENAPVGTEVLTVTATDPDLGPNGRIFYSiLGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLSS 83


                  ....*....
gi 1907100841 623 VATVALTVL 631
Cdd:pfam00028  84 TATVTITVL 92
Cadherin pfam00028
Cadherin domain;
645-734 4.13e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 82.73  E-value: 4.13e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841 645 FSFFVPENFPGYGEIGVISVTDADAGRNGWVALSVMNQ--SDIFVIDTGKGMLRAKVSLDREQQSSYTLWVEAVDGGEPA 722
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgpGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                          90
                  ....*....|..
gi 1907100841 723 LSSTTKITILLL 734
Cdd:pfam00028  81 LSSTATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 755-846 1.10e-18

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.98  E-value: 1.10e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841 755 VLPSTLPGSPVTEVYAVDKDTGMNAVIAYSIIGrrGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPePL 834
Cdd:cd11304     6 VPENAPPGTVVLTVSATDPDSGENGEVTYSIVS--GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP-PL 82

                          90
                  ....*....|..
gi 1907100841 835 HSTVMVNLFVND 846
Cdd:cd11304    83 SSTATVTITVLD 94
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 235-319 1.05e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 78.55  E-value: 1.05e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841  235 AVDPDVGINGVQTYRLLD--YHGMFTLDveenengERTPYLIVMGALDRETQDQYVSIIIAEDGGSPPLLGSATLTIGIS 312
Cdd:smart00112   2 ATDADSGENGKVTYSILSgnDDGLFSID-------PETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....*..
gi 1907100841  313 DINDNCP 319
Cdd:smart00112  75 DVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 325-417 7.54e-16

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 73.89  E-value: 7.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841 325 QINVTVYGNATVGTPVATVQAVDRDLGTNAQITYSYsqkVPQETKDLFHLDEVTGVIKLSSKIGGSVLQTHKLTILANGP 404
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSI---VSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                          90
                  ....*....|...
gi 1907100841 405 GCIPAVITALVSI 417
Cdd:cd11304    78 GGPPLSSTATVTI 90
Cadherin pfam00028
Cadherin domain;
219-309 4.76e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 68.48  E-value: 4.76e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841 219 VPENSPVNTRLAIEHpAVDPDVGINGVQTYRLL--DYHGMFTLDveenengERTPYLIVMGALDRETQDQYVSIIIAEDG 296
Cdd:pfam00028   5 VPENAPVGTEVLTVT-ATDPDLGPNGRIFYSILggGPGGNFRID-------PDTGDISTTKPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|...
gi 1907100841 297 GSPPLLGSATLTI 309
Cdd:pfam00028  77 GGPPLSSTATVTI 89
Cadherin pfam00028
Cadherin domain;
761-844 1.69e-13

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 66.94  E-value: 1.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841 761 PGSPVTEVYAVDKDTGMNAVIAYSIIGrrGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPePLHSTVMV 840
Cdd:pfam00028  11 VGTEVLTVTATDPDLGPNGRIFYSILG--GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP-PLSSTATV 87


                  ....
gi 1907100841 841 NLFV 844
Cdd:pfam00028  88 TITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 770-846 7.10e-13

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 64.68  E-value: 7.10e-13
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907100841  770 AVDKDTGMNAVIAYSIIGrrGPRPESFRIDPKTGNITLEEALLQTDYGLHRLLVKVSDHGYPePLHSTVMVNLFVND 846
Cdd:smart00112   2 ATDADSGENGKVTYSILS--GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVLD 75
Cadherin pfam00028
Cadherin domain;
326-417 5.56e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 56.93  E-value: 5.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841 326 INVTVYGNATVGTPVATVQAVDRDLGTNAQITYSysqKVPQETKDLFHLDEVTGVIKLSSKIGGSVLQTHKLTILANGPG 405
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYS---ILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                          90
                  ....*....|..
gi 1907100841 406 CIPAVITALVSI 417
Cdd:pfam00028  78 GPPLSSTATVTI 89
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 344-418 1.30e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 46.96  E-value: 1.30e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907100841  344 QAVDRDLGTNAQITYSysqKVPQETKDLFHLDEVTGVIKLSSKIGGSVLQTHKLTILANGPGCIPAVITALVSII 418
Cdd:smart00112   1 SATDADSGENGKVTYS---ILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTIT 72
Cadherin_2 pfam08266
Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.
 70-153 1.24e-04

Cadherin-like; This cadherin domain is usually the most N-terminal copy of the domain.


Pssm-ID: 462413  Cd Length: 83  Bit Score: 41.36  E-value: 1.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841  70 YSLNEGLPAGVLIGSLAEDLRLLPRA-SGRqnqqllhpertasegnpplSFSLASGGlSGQYVTLNNRSGELHTSaQEID 148
Cdd:pfam08266   4 YSVPEETERGSFVGNLAKDLGLEVGElAAR-------------------GARVVSKG-NKQYFQLNPETGDLLLN-EKLD 62


                  ....*
gi 1907100841 149 REALC 153
Cdd:pfam08266  63 REELC 67
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 562-636 1.96e-04

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 41.56  E-value: 1.96e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907100841 562 DADSGEMGRVSYFLGPDAPSYFSLDSVTGILTVSTQLDREEKEKYRYTVRAVDCGTPPRESVATVALTVLDKNDN 636
Cdd:cd00031    24 IASSGEIIKISAAGKEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVPQTSSVFSIEVYDENDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 490-534 1.03e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.87  E-value: 1.03e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1907100841  490 LETTKPMDYEVQSFYEIAVVA--WNSEGFHVKRIIKVQLLDDNDNAP 534
Cdd:smart00112  35 ITTTKPLDREEQPEYTLTVEAtdGGGPPLSSTATVTITVLDVNDNAP 81
Cadherin pfam00028
Cadherin domain;
439-510 1.70e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 38.44  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907100841 439 VVYLKELEPVNTPIAFFTIRDPEG------KYKIncfLDGE--GPFRLAPYKPynneyLLETTKPMDYEVQSFYEIAVVA 510
Cdd:pfam00028   2 SASVPENAPVGTEVLTVTATDPDLgpngriFYSI---LGGGpgGNFRIDPDTG-----DISTTKPLDRESIGEYELTVEA 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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