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Conserved domains on  [gi|1907075448|ref|XP_036011707|]
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transmembrane and coiled-coil domain protein 3 isoform X1 [Mus musculus]

Protein Classification

transmembrane and coiled-coil domain protein( domain architecture ID 11186040)

transmembrane and coiled-coil domain protein may be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tmemb_cc2 pfam10267
Predicted transmembrane and coiled-coil 2 protein; This family of transmembrane coiled-coil ...
 64-504 0e+00

Predicted transmembrane and coiled-coil 2 protein; This family of transmembrane coiled-coil containing proteins is conserved from worms to humans. Its function is unknown.


:

Pssm-ID: 463036  Cd Length: 401  Bit Score: 574.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907075448  64 VKLNADSLRQKILKVTEQIKIEQTSRDGNVAEYLKLVSSADKQQAGRIKQVFEKKNQKSAHSIAQLQKKLEQYHRKLREI 143
Cdd:pfam10267   1 SRAAIEHLQQKILKIKEQIKIEQTARDENVAEYLKLANNADKQQLARIKQVFEKKNQKSAQNIAQLQKKLEQYHRRLKEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907075448 144 E---QNGVTRSSKdiSKDSLKEIHHSLKDAHVKSRtaphclesskSSMPGVSLTPPVFVFNKSREFANLIRNKFGSADNI 220
Cdd:pfam10267  81 EngeQSSVTSHRQ--PKEVLRDVGQGLRDVGGNIR----------DGISGLSGGPPPTVFSKPREFAHLIKNKFGSADNI 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907075448 221 AHLKNSLEEFRPEASPRAYGGS-ATIVNKPKYGSDDECSSGT--SGSADSNGNQSFGA----GGTSTLDSQGKIAKIMEE 293
Cdd:pfam10267 149 NSLKSSLETSHDEGGGRKLSGStFSTVTKPKYPSDDECSSSSveSISAGSNGNPPPHGadngGQQAESDSQNGLAAILEE 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907075448 294 LREIKVTQTQLAEDIEALKVQFKREYGFISQTLQEERYRktvfqgmktsqgpqdkkghhsrprrwntcapcslrllsllr 373
Cdd:pfam10267 229 LQEIKEAQVQLEEKLERLKTQFKKEYKFLTQALQEERYR----------------------------------------- 267

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907075448 374 YERLEDQLHDLTELHQHETANLKQELASAEEKVAYQAYERSRDIQEALESCQTRISKLELHQQEQQTLQTDAV---NAKV 450
Cdd:pfam10267 268 YERLEEQLNDLTELHQNEIANLKQELASMEEKVAYQSYERARDIQEALESCQTRISKMELQQQQQQLVQLEGLenaNARA 347

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907075448 451 LLGKCINVVLAFMTVILVCVSTLAKFVSPMMKSRSHILGTFFAVTLLAIFCKNW 504
Cdd:pfam10267 348 LLGKLINIVLAILTVILVLVSTAAKFVAPLLKTRLRILTTILLVLLLIIFWKNW 401
 
Name Accession Description Interval E-value
Tmemb_cc2 pfam10267
Predicted transmembrane and coiled-coil 2 protein; This family of transmembrane coiled-coil ...
 64-504 0e+00

Predicted transmembrane and coiled-coil 2 protein; This family of transmembrane coiled-coil containing proteins is conserved from worms to humans. Its function is unknown.


Pssm-ID: 463036  Cd Length: 401  Bit Score: 574.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907075448  64 VKLNADSLRQKILKVTEQIKIEQTSRDGNVAEYLKLVSSADKQQAGRIKQVFEKKNQKSAHSIAQLQKKLEQYHRKLREI 143
Cdd:pfam10267   1 SRAAIEHLQQKILKIKEQIKIEQTARDENVAEYLKLANNADKQQLARIKQVFEKKNQKSAQNIAQLQKKLEQYHRRLKEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907075448 144 E---QNGVTRSSKdiSKDSLKEIHHSLKDAHVKSRtaphclesskSSMPGVSLTPPVFVFNKSREFANLIRNKFGSADNI 220
Cdd:pfam10267  81 EngeQSSVTSHRQ--PKEVLRDVGQGLRDVGGNIR----------DGISGLSGGPPPTVFSKPREFAHLIKNKFGSADNI 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907075448 221 AHLKNSLEEFRPEASPRAYGGS-ATIVNKPKYGSDDECSSGT--SGSADSNGNQSFGA----GGTSTLDSQGKIAKIMEE 293
Cdd:pfam10267 149 NSLKSSLETSHDEGGGRKLSGStFSTVTKPKYPSDDECSSSSveSISAGSNGNPPPHGadngGQQAESDSQNGLAAILEE 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907075448 294 LREIKVTQTQLAEDIEALKVQFKREYGFISQTLQEERYRktvfqgmktsqgpqdkkghhsrprrwntcapcslrllsllr 373
Cdd:pfam10267 229 LQEIKEAQVQLEEKLERLKTQFKKEYKFLTQALQEERYR----------------------------------------- 267

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907075448 374 YERLEDQLHDLTELHQHETANLKQELASAEEKVAYQAYERSRDIQEALESCQTRISKLELHQQEQQTLQTDAV---NAKV 450
Cdd:pfam10267 268 YERLEEQLNDLTELHQNEIANLKQELASMEEKVAYQSYERARDIQEALESCQTRISKMELQQQQQQLVQLEGLenaNARA 347

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907075448 451 LLGKCINVVLAFMTVILVCVSTLAKFVSPMMKSRSHILGTFFAVTLLAIFCKNW 504
Cdd:pfam10267 348 LLGKLINIVLAILTVILVLVSTAAKFVAPLLKTRLRILTTILLVLLLIIFWKNW 401
 
Name Accession Description Interval E-value
Tmemb_cc2 pfam10267
Predicted transmembrane and coiled-coil 2 protein; This family of transmembrane coiled-coil ...
 64-504 0e+00

Predicted transmembrane and coiled-coil 2 protein; This family of transmembrane coiled-coil containing proteins is conserved from worms to humans. Its function is unknown.


Pssm-ID: 463036  Cd Length: 401  Bit Score: 574.67  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907075448  64 VKLNADSLRQKILKVTEQIKIEQTSRDGNVAEYLKLVSSADKQQAGRIKQVFEKKNQKSAHSIAQLQKKLEQYHRKLREI 143
Cdd:pfam10267   1 SRAAIEHLQQKILKIKEQIKIEQTARDENVAEYLKLANNADKQQLARIKQVFEKKNQKSAQNIAQLQKKLEQYHRRLKEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907075448 144 E---QNGVTRSSKdiSKDSLKEIHHSLKDAHVKSRtaphclesskSSMPGVSLTPPVFVFNKSREFANLIRNKFGSADNI 220
Cdd:pfam10267  81 EngeQSSVTSHRQ--PKEVLRDVGQGLRDVGGNIR----------DGISGLSGGPPPTVFSKPREFAHLIKNKFGSADNI 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907075448 221 AHLKNSLEEFRPEASPRAYGGS-ATIVNKPKYGSDDECSSGT--SGSADSNGNQSFGA----GGTSTLDSQGKIAKIMEE 293
Cdd:pfam10267 149 NSLKSSLETSHDEGGGRKLSGStFSTVTKPKYPSDDECSSSSveSISAGSNGNPPPHGadngGQQAESDSQNGLAAILEE 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907075448 294 LREIKVTQTQLAEDIEALKVQFKREYGFISQTLQEERYRktvfqgmktsqgpqdkkghhsrprrwntcapcslrllsllr 373
Cdd:pfam10267 229 LQEIKEAQVQLEEKLERLKTQFKKEYKFLTQALQEERYR----------------------------------------- 267

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907075448 374 YERLEDQLHDLTELHQHETANLKQELASAEEKVAYQAYERSRDIQEALESCQTRISKLELHQQEQQTLQTDAV---NAKV 450
Cdd:pfam10267 268 YERLEEQLNDLTELHQNEIANLKQELASMEEKVAYQSYERARDIQEALESCQTRISKMELQQQQQQLVQLEGLenaNARA 347

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907075448 451 LLGKCINVVLAFMTVILVCVSTLAKFVSPMMKSRSHILGTFFAVTLLAIFCKNW 504
Cdd:pfam10267 348 LLGKLINIVLAILTVILVLVSTAAKFVAPLLKTRLRILTTILLVLLLIIFWKNW 401
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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